CN104203195A - 具有带有套筒弹出装置的套筒端口的流体转移装置 - Google Patents
具有带有套筒弹出装置的套筒端口的流体转移装置 Download PDFInfo
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Abstract
用于手动套筒填充过程的流体转移装置,其用来使套筒填充来自含有药物的小瓶的液体药物剂量。该流体转移装置包括双端主体,该双端主体具有纵轴、用于以套叠方式接收药物小瓶的小瓶端口和用于滑动地接收前导套筒端的套筒端口。该套筒端口包括套筒锁定装置和套筒弹出装置,该套筒锁定装置用于可释放地锁定该套筒端口中的该前导套筒端,该套筒弹出装置用于至少部分地将该套筒从套筒端口中弹出以辅助已填充的套筒的手动滑动弹出。该套筒端口可包括组合的套筒锁定和弹出装置或分离的套筒锁定装置和分离的套筒弹出装置。
Description
技术领域
本发明涉及用于使套筒(cartrodge)填充液体药物剂量的流体转移装置。
背景技术
用于自己给予液体药物(比如胰岛素)的自动注射器通常采用所谓的卡普耳(carpules)或包括末端开口的管子的套筒,该套筒由在前导套筒端处的橡胶隔片和在相反的尾随套筒端处的可移动的密封物气密封。套筒可包含单个液体药物剂量或多个液体药物剂量。家庭使用者通常配备有预填充有液体药物剂量的套筒,但也可配备有空的套筒,该空的套筒要求用液体药物剂量填充的手动套筒填充过程。该手动套筒填充过程包括以下步骤:使用者准备具有液体药物剂量的注射器,将针头安装在注射器上,刺穿套筒的橡胶隔片并且将该液体药物剂量注射到套筒中。使用者可以有从粉末状的药物重构液体药物剂量的其它步骤。
发明名称为与套筒一起使用的流体转移装置,以PCT国际公开号WO 2007/105221公开的共同拥有的PCT国际申请号PCT/IL2007/000343公开了如下文所讨论的与无针头注射器和套筒一起使用的用于辅助手动套筒填充过程的流体转移装置。
发明名称为用于使套筒填充液体药物剂量的流体转移装置,以PCT国际公开号WO2011/004360公开的共同拥有的PCT国际申请号PCT/IL2010/000530公开了如下文所讨论的与套筒和小瓶一起使用的用于辅助手动套筒填充过程的流体转移装置。WO 2011/004360公开了提供其它传统的套筒,其包括具有可释放连接布置的可滑动密封物和用于该可滑动密封物的可释放连接的手动推杆,该手动推杆用来使该可滑动密封物手动移位以达到注射和吸入目的。合适的可释放连接布置尤其包括螺纹布置等。
需要一流体转移装置,其用于使用于液体药物剂量填充套筒的手动套筒填充过程和用于随后的自动注射器中的部署的已填充的套筒手动滑动弹出更容易。
发明内容
本发明针对的是用于手动套筒填充过程的流体转移装置,用于使套筒填充来自含有药物的小瓶的液体药物剂量。该流体转移装置包括双端主体(double ended main body),该双端主体具有纵轴、用于以套叠方式接收药物小瓶的小瓶端口和用于滑动地接收前导套筒端的套筒端口。该套筒端口包括套筒锁定装置(cartridge securing arrangement)和套筒弹出装置(cartridge ejectionarrangement),该套筒锁定装置用于可释放地在套筒端口中锁定前导套筒端,该套筒弹出装置用来至少部分地将已填充的套筒从该套筒端口中弹出以辅助其完全地滑动弹出。该流体转移装置优选地包括一对向外横向指向的手指状支撑物(outward transverse directed finger support),用来使用户能够按照类似注射器的方式使用它们。
套筒端口可包括组合的套筒锁定和弹出装置,该组合的套筒锁定和弹出装置包括一个或多个用来在套筒端口中锁定套筒并且给予用来至少部分地将已填充的套筒从套筒端口中弹出的杠杆活动的杆杠部件。或者,该套筒端口包括分离的套筒锁定装置和分离的套筒弹出装置。此类分离的套筒弹出装置包括一个或多个套筒弹出部件,当使套筒手动滑动***进入套筒端口中的锁定位置中时,该套筒弹出部件被偏置成准备好的状态。当手动释放该套筒锁定装置时,该一个或多个套筒弹出部件恢复到它们的未偏置状态,用来至少部分地将已填充的套筒从套筒端口弹出。
附图说明
为了理解本发明,并且明白在实际中如何实施它,结合附图,仅仅借助非限制性实施例,优选的实施例被描述了,附图中类似的部分采用了同样的编号,并且其中:
图1对应于提到的PCT国际公开号WO 2007/105221中的图2;
图2对应于提到的PCT国际公开号WO 2007/105221中的图5;
图3对应于提到的PCT国际公开号WO 2011/004360中的图2;
图4对应于提到的PCT国际公开号WO 2011/004360中的图6;
图5是根据本发明的第一优选实施例,包括预填充的套筒、推杆、药物小瓶和具有组合的套筒锁定和弹出装置的流体转移装置的成套用具的图示;
图6是图5的流体转移装置的部件分解图;
图7是图5的流体转移装置的正视图,它的组合的套筒锁定和弹出装置在最初的套筒***位置;
图8A是图5的流体转移装置沿图7中的A-A线的纵向截面图;
图8B是图8A中的圆形区域的放大图,显示了组合的套筒锁定和弹出装置的前导杠杆部件端;
图9是图5的流体转移装置的正视图,它的组合的套筒锁定和弹出装置在最终的套筒弹出位置;
图10是图5中的流体转移装置沿着图9中的B-B线的纵向截面图;
图11A是图5的流体转移装置的纵向截面图,显示了锁定定在其组合的锁定和弹出装置中的套筒;
图11B是图11A中圆形区域的放大图,显示了前导套筒端的锁定;
图12是图5的流体转移装置的纵向截面图,显示了套筒从套筒端口的部分弹出;
图13A到13H显示了图5的流体转移装置用来使套筒填充重构的液体药物剂量;
图14是根据本发明的第二优选实施例,包括组合的套筒锁定和弹出装置的流体转移装置的正透视图;
图15A是当将套筒滑动***到套筒端口中时,图14的流体转移装置沿图14中的C-C线的纵向截面图;
图15B是当手动操作其组合的套筒锁定和弹出装置,使套筒至少部分地从套筒端口中弹出时,图14的流体转移装置沿图14中的C-C线的纵向截面图;
图16是根据本发明第三优选实施例,包括分离的套筒锁定装置和分离的套筒弹出装置的流体转移装置的正透视图,;
图17是图16的流体转移装置沿着图16中的线D-D的纵向截面图;以及
图18是当使套筒滑动***到其套筒端口中以准备好其套筒弹出装置时,图16的流体转移装置沿着图16中的线D-D的纵向截面图。
本发明的优选具体实施例的详细描述
图1对应于提到的WO 2007/105221的图2,显示了流体转移装置30包括双端主体31,纵轴32,用于接收无针头注射器的注射器端口33和用于以套叠方式接收套筒的套筒端口34。
图2对应于WO 2007/105221的图5,显示了流体转移装置50在构造和操作上类似于具有旋转地可拆开的小瓶转接器的流体控制装置30,该流体控制装置30在Zinger等共同拥有的美国专利号6,238,372的图11到图15中公开了。
图3对应于WO 2011/004360的图2,显示了流体转移装置40包括具有用来滑动接收套筒前导端的套筒端口43和用来卡扣配合到小瓶上的小瓶端口44的双端主体42。
图4对应于WO 2011/004360的图6,显示了流体转移装置60包括公连接头61,用来滑动地接收套筒的末端开口的套筒固定器(open ended cartridge holder)62和手指操作的套筒卡扣配合装置(finger operated cartridge snap fit arrangement)63,该手指操作的套筒卡扣配合装置用于,当套筒滑动***到套筒固定器62中时,初始地卡扣配合到套筒上,且能够使用户手动地释放套筒以使套筒能够从套筒固定器62自由地滑动地被取出。
图5显示了成套用具100,其包括预填充的套筒110,具有螺纹前导端126的推杆124,药物小瓶130和用于手动套筒填充过程中使套筒110填充液体药物剂量的流体转移装置140。
图6到12显示了套筒110,其包括具有纵轴112的末端开口的管子111,小直径的前导套筒端113,中间的颈部114和宽直径的尾随套筒端116。该前导套筒端113被由金属带118包住的橡胶套筒隔片117气密封。该前导套筒端113具有最前端的套筒表面119,其包括暴露的2mm到3mm直径的环形橡胶表面119A。尾随端116由可滑动密封物121气密封。该可滑动密封物121具有暴露的尾随表面122,该尾随表面122与螺纹盲孔123一起形成,用于与推杆的螺纹前导端126螺纹连接。该套筒110预填充有液体内含物127。该液体内含物127通常是用于重构粉末状药物的稀释剂。或者,该液体内含物127包括活性成分。
药物小瓶130包括顶部开口的小瓶瓶体131,小瓶瓶体131具有纵轴132,并且被由金属带134包住的小瓶瓶塞133气密封。药物小瓶130含有粉末状或液体药物内含物136。粉末状药物内含物136通常在负压下被储存并且需要在给药之前重构。或者,药物小瓶130可含有适合于直接转移到空的套筒中的液体药物。
流体转移装置140具有纵轴141,并且包括双端主体142。该双端主体142具有用于以套叠方式接收药物小瓶130的小瓶端口143和用于滑动地接收前导套筒端113的套筒端口144。
小瓶端口143包括具有多个弯曲部件147的有沟槽的裙146和与流体转移装置的纵轴141同轴的穿刺套管149,该弯曲部件147具有用于卡扣配合到药物小瓶130上的向内指向的脊线(inwardly directed ridge)148。当使药物小瓶130卡扣配合***到小瓶端口133中时,该穿刺套管149用来刺穿小瓶瓶塞133。
套筒端口144包括与一对相对的套筒支撑物(cartridge support)152一起形成的底部表面151,当前导套筒端113滑动地被***套筒端口144中时,该套筒支撑物152用来提供对前导套筒端113的轴向支撑。套筒端口144还包括穿刺部件153,当前导套筒端113滑动地***套筒端口144中时,该穿刺部件153用来刺穿套筒隔片117。穿刺部件153优选由具有例如约0.5mm的外部直径的金属针构成。穿刺部件153还与流体转移装置的纵轴141同轴,并且与穿刺套管149流体连通以使流体转移装置140、套筒110和药物小瓶130的组合件中的套筒110和药物小瓶130之间能够直接流体连通。套筒支撑对(cartridge support pair)152具有凹痕(indent)154(见图10)。
此外,套筒端口144设置有组合的套筒锁定和弹出装置160,用来可释放地锁定套筒端口144中的前导套筒端113和至少部分地将填充有液体药物剂量的套筒110从套筒端口144中弹出。该组合的套筒锁定和弹出装置160包括一对相对的延长的杠杆部件161A和161B。杠杆部件对161延伸超过套筒支撑物152,并且在最初的套筒***位置与纵轴141同方向以辅助引导套筒110手动滑动***到套筒端口144中(参见图5,7和8A)。
杠杆部件对161A和161B相应地具有接近小瓶端口143的前导杠杆部件端162A和162B和远离小瓶端口143的尾随杠杆部件端163A和163B。杠杆部件对161在它们的前导杠杆部件端162处枢轴安装在主体142上,用来从它们最初的套筒***位置被手动撬动到在最终的套筒弹出位置中相对于纵轴141向外倾斜(参见图9,10和12)。
前导杠杆部件端对162A和162B具有相应地最前端的边缘164A和164B,最后端的边缘166A和166B和中间的部分167A和167B。最前端的边缘164具有分别背向和朝向小瓶端口143的最上面的表面168和最下面的表面169。最前端的边缘164与凹痕171一起形成,用来卡扣配合接收形成在相对的套筒支撑物152上的插脚(pin)172,以使杠杆部件对161能够枢轴活动。在最初的套筒***位置,最前端的边缘164压在底部表面151,并且在两个边缘之间限定比前导套筒端113直径小的距离。
杠杆部件对161尺寸被设计以致,当套筒10完全***到套筒端口144中时,它们延伸到套筒110的中间,并且其尾随杠杆部件端163A和163B与相对于纵轴141向外横向指向的手指状支撑物173A和173B一起形成,以使流体转移装置140能够按照类似于注射器的方式被使用。
杠杆部件对161与突出部分174一起形成,用来啮合套筒支撑对152上的凹痕154,用来在套筒110滑动***套筒端口144期间在它们的最初的同方向位置锁定杠杆部件对161。
图11A和11B显示了当其前导套筒端113完全***到套筒端口144中时,最前端的套筒表面119紧靠最前端的边缘164的最上面的表面168与底部表面151隔开。图11A和11B还显示了,中间的部分167尺寸被设计成使得最后端的边缘166卡扣配合到前导套筒端113用于锁定目的。
图12显示了杠杆部件对161的手动撬动引起它们在它们的前导杠杆部件端162处在枢轴上转动,以致它们的最前端的边缘164靠在套筒的最前端的套筒表面119活动以至少部分地将套筒110从套筒端口144中弹出,用于辅助套筒110从中套筒端口144中的完全手动滑动弹出。
图13A到13H显示了使用成套用具100来重构液体药物剂量,随后,将液体药物剂量吸入到套筒中:
图13A显示了如箭头A所示,使用者将预填充有稀释剂的套筒***到套筒端口中。
图13B显示了如箭B所示,使用者将推杆螺纹安装进入预填充的套筒中。
图13C显示了如箭C所示,使用者将小瓶端口卡扣配合到药物小瓶上。
图13D显示了如箭头D所示,使用者将套筒的内含物注射到小瓶中用于重构目的,用来重构药物小瓶中的粉末状药物以形成重构的液体药物LD。
图13E显示了填充有液体药物LD的药物小瓶。
图13F显示了使用者倒置了流体转移装置、药物小瓶和套筒的组合件,并且如箭头E所示,使用者将液体药物LD吸入到套筒中。
图13G显示了使用者反转了组合件。
图13H显示了如箭头F所示,使用者相对于纵轴向外手动撬动杠杆部件对以部分地将已填充的套筒从套筒端口中弹出。已填充的套筒很容易地完全地从套筒端口中被滑动弹出。
图14和15显示了在构造和操作上类似于流体转移装置140的流体转移装置180。前者180与后者140的不同之处在于前者180包括延长的套筒端口181,当套筒110完全***套筒端口181时,该延长的套筒端口181延伸到套筒110的大约中间处,且与一对向外横向指向的手指状支撑物182整体成形以使流体转移装置180能够按照类似注射器的方式被使用。该流体转移装置180包括组合的套筒锁定和弹出装置183,其具有单个杠杆部件184用于锁定和弹出目的。杠杆部件184通过靠着其末端开口的管子111的前导端推动至少部分地弹出已填充的套筒110,这不同于前者140的情况中最前端的套筒表面119。
图16到18显示了在构造和操作上类似于流体转移装置140的流体转移装置190。前者190与后者140的不同之处在于前者190包括具有相对的套筒支撑物192的延长的套筒端口191,该相对的套筒支撑物192在环形的套筒端口底部193处终止,该环形的套筒端口底部(base)193与一对向外横向指向的手指状支撑物194一起成形,以使流体转移装置190能够按照类似于注射器的方式被使用。延长的套筒端口191与分离的套筒锁定装置196一起形成,用于在套筒端口191中锁定套筒110。套筒锁定装置196类似于WO 2011/004360图6中的手指操作的套筒卡扣配合装置63(参见图4),并且包括一对有弹性地灵活地安装在套筒端口底部193处的相对的弯曲部件197。弯曲部件197各自具有向外指向的手指操作部件198,并且在向内定向的脊线199处终止,用于当将套筒110滑动***到套筒端口191中时紧贴套筒的中间的颈部114的卡扣配合***。如箭头G所示,朝向彼此按压一对手指操作部件198向外推动向内指向的脊线199,从而释放套筒110。
流体转移装置190还包括分离的套筒弹出装置201,用于选择性地至少部分地将套筒110从套筒端口191中弹出以辅助已填充的套筒从套筒端口191中的完全手动滑动弹出。分离的套筒弹出装置201包括至少一个套筒弹出部件202,当使前导套筒端113手动滑动***到套筒端口191中进入由分离的套筒锁定装置196锁定的锁定位置中时,该套筒弹出部件202偏置进入准备好的状态。该套筒弹出部件202由弹簧片部件、弹簧等构成。该套筒弹出装置201包括一对弹簧片部件202。当通过按压一对手指操作部件198手动释放套筒锁定装置196时,套筒弹出部件202从套筒端口191向外推动前导套筒端113,用于辅助已填充的套筒的完全手动滑动弹出。
虽然本发明描述了相对有限数目个具体实施例,应当认识到本发明的许多变化、修改和其它实施可以在所附的权利要求的范围内做出。
Claims (7)
1.流体转移装置,其用于与套筒和药物小瓶一起使用,用来使套筒填充液体药物剂量,所述套筒包括具有前导套筒端和尾随套筒端的末端开口的管子,所述前导套筒端由套筒隔片密封,所述尾随套筒端由可滑动的密封物密封,所述前导套筒端具有最前端的套筒表面,所述药物小瓶包括含有药物成分的药物小瓶瓶体,并且具有由药物小瓶瓶塞密封的药物小瓶开口,所述流体转移装置包括:
双端主体,其具有纵轴,并且包括小瓶端口和套筒端口,所述小瓶端口用于以套叠方式接收药物小瓶,并且具有用于穿刺所述药物小瓶瓶塞以与所述药物小瓶瓶体流体连通的穿刺套管,所述套筒端口具有
i)穿刺针,用于当朝向所述小瓶端口将所述套筒手动滑动***到所述套筒端口中时刺穿所述套筒隔片以与所述末端开口的管子流体连通,所述穿刺套管与所述穿刺针流体连通以实现使套筒填充液体药物剂量的手动套筒填充过程,
ii)套筒锁定装置,用于当所述手动滑动***到所述套筒端口中时在所述套筒端口中可释放地锁定套筒,以及
iii)套筒弹出装置,用于至少部分地将已填充的套筒从所述套筒端口中弹出以辅助所述已填充的套筒从所述套筒端口中的完全滑动弹出。
2.根据权利要求1所述的装置,其中所述套筒端口包括具有至少一个杠杆部件的组合的套筒锁定和弹出装置,所述至少一个杠杆部件具有相应地接近和远离所述小瓶端口的前导杠杆部件端和尾随杠杆部件端。
每一个所述至少一个杠杆部件在其所述前导杠杆部件端处枢轴安装在所述主体上,用以从与所述纵轴同向的套筒***位置被手动撬动到套筒弹出位置,所述套筒***位置用于实现所述手动滑动***到所述套筒端口中,所述套筒弹出位置用于所述至少部分地将所述已填充的套筒从所述套筒端口弹出。
3.根据权利要求2所述的装置,其中,所述组合的套筒锁定和弹出装置包括一对相对的延长的杠杆部件,所述杠杆部件与所述纵轴同向且尺寸设计成用于引导所述套筒到所述套筒端口中的所述手动滑动***。
4.根据权利要求3所述的装置,其中,所述一对相对的延长的杠杆部件在所述最初的套筒***位置延伸到套筒中间,并且所述一对相对的杠杆部件的每一个所述尾随杠杆部件端包括用来使所述流体转移装置能够按照类似于注射器的方式被使用的向外横向指向的手指状支撑物。
5.根据权利要求2所述的装置,其中所述套筒端口被延长,并且尺寸设计成当所述手动滑动***所述套筒端口中时延伸到套筒中间,并且与一对相对的向外横向指向的手指状支撑物一起形成以使所述流体转移装置能够按照类似于注射器的方式被使用。
6.根据权利要求1所述的装置,其中,所述套筒弹出装置包括至少一个套筒弹出部件,当将所述套筒端口中的所述套筒锁定在其上时,所述套筒弹出部件偏置成准备好的状态,当手动释放所述套筒锁定装置时,所述至少一个套筒弹出部件至少部分地将所述套筒从所述套筒端口中弹出。
7.根据权利要求6所述的装置,其中所述套筒端口被延长,并且尺寸设计成当所述手动滑动***所述套筒端口中时延伸到套筒中间,并且与一对相对的向外横向指向的手指状支撑物一起形成以使所述流体转移装置能够按照类似于注射器的方式被使用。
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- 2013-04-07 IN IN9054DEN2014 patent/IN2014DN09054A/en unknown
- 2013-04-07 JP JP2015503992A patent/JP5740069B2/ja active Active
- 2013-04-07 US US14/385,212 patent/US9283324B2/en active Active
- 2013-04-07 WO PCT/IL2013/050313 patent/WO2013150538A1/en active Application Filing
- 2013-04-07 DK DK13721118.1T patent/DK2814446T3/en active
- 2013-04-07 BR BR112014024530-4A patent/BR112014024530B1/pt active IP Right Grant
- 2013-04-07 EP EP13721118.1A patent/EP2814446B1/en active Active
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CN113181477A (zh) * | 2015-06-04 | 2021-07-30 | 麦迪麦珀医疗工程有限公司 | 用于药物释放装置的筒*** |
CN113181477B (zh) * | 2015-06-04 | 2023-07-14 | 麦迪麦珀医疗工程有限公司 | 用于药物释放装置的筒*** |
CN114948726A (zh) * | 2022-07-29 | 2022-08-30 | 上海奥科达生物医药科技有限公司 | 一种液体制剂多次给药*** |
Also Published As
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US20150088078A1 (en) | 2015-03-26 |
EP2814446A1 (en) | 2014-12-24 |
JP5740069B2 (ja) | 2015-06-24 |
CN104203195B (zh) | 2016-12-14 |
BR112014024530B1 (pt) | 2020-11-24 |
IL219065A0 (en) | 2012-07-31 |
IL234558B (en) | 2018-04-30 |
EP2814446B1 (en) | 2016-09-14 |
IN2014DN09054A (zh) | 2015-05-22 |
DK2814446T3 (en) | 2016-12-19 |
JP2015516842A (ja) | 2015-06-18 |
US9283324B2 (en) | 2016-03-15 |
WO2013150538A1 (en) | 2013-10-10 |
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