CN104189267A - Traditional Chinese medicine composition for treating kidney stone and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating kidney stone and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating kidney stone and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: desmodium styracifolium, lygodium japonicum, chicken's gizzard-membrane, liquorice, agilawood, yellow croaker ear-stone, amber, pyrrosia lingua, radix paeoniae alba, talc, dianthus superbus, platycladi seed and lycium barbarum. The traditional Chinese medicine composition provided by the invention can effectively treat clinical symptoms such as paroxysmal lumbago with hematuresis and the like caused by kidney stone.
Description
Technical field
The field of Chinese medicines that the present invention relates to treatment, is specifically related to Chinese medicine composition for the treatment of renal calculus and preparation method thereof.
Background technology
Urinary system calculus belongs to " sand Stranguria ", " stranguria caused by urinary stone " and " stranguria with blood " scope in traditional Chinese medical science gonorrhea, mainly comprises 4 kinds of pattern of syndrome:
(1) qi stagnation and blood stasis type: disease is seen waist dull pain, dull pain, the normal or stringy and tense pulse of arteries and veins, tongue is normal; Or urine is interrupted suddenly when excessive, sharp ache, the upper waist abdomen that connects, sandstone discharge after pain slow; Or waist, flank portion tugging pain be as strand, pain extending to the lower abdomen, outbreak again and again, pale complexion, cold sweat, vomiting and nausea when pain, companion's hematuria or urine yellow skin are red, dimly red tongue or have petechia, ecchymosis, stringy and tense pulse or slow puckery.
(2) damp heat downward flowing type: card is shown in fever with aversion to cold, lumbago, few abdomen is anxious full, and frequent micturition is short red, and while drowning, puckery pain unbearably, is drenched drop not well.Yellow and greasy fur, stringy and rolling pulse or sliding number.
(3) deficiency of the kidney yin type: calculus is stopped for a long time, pathogenic heat are strongly fragrant for a long time.Kidney-Yin loss, dizzy tinnitus, pain in the low back and legs, dribbling urination or not well, insomnia and dreamful sleep, time have low grade fever, shortness of breath and palpitation, dysphoria with feverish sensation in the chest palms and soles, night sweat, eye is dry or puckery, abdominal distention constipation, poor appetite, thready and rapid pulse, red tongue or few tongue.
(4) kidney yang deficiency syndrome: calculus is stayed for a long time, kidney yang deficiency, the acid of waist lower limb is heavy, lassitude, whole body is timid cold, and extremities being not warm or the lower part of the body often have creeping chill, frequent micturition or dysuria, frequent urination at night, complexion is white, a little less than deep-thready pulse, the white pale tongue of tongue.
Renal calculus belongs to the one of sand Stranguria, and renal calculus is urinary system commonly encountered diseases, frequently-occurring disease, and male falls ill more than women, mostly occurs person between twenty and fifty, the sickness rate no significant difference of left and right sides.There is 40%～75% renal calculus patient to have lumbago in various degree.Calculus is larger, and degree of excursion is very little, shows as the swollen discomfort of waist acid, or in the time that body movement increases, has dull pain or dull pain., often there is the waist and belly sample that lancinates and have an intense pain in the angor causing compared with microlith, is paroxysmal suddenly.
The patient of renal calculus does not have symptom mostly, causes ureteral urine to block unless renal calculus drops to ureter from kidney.Common symptom has lumbago, night sweat, pain to dizzy, nauseating, vomiting, dysphoria, the vexed pain of abdominal part, hematuria etc.If, also may there is the phenomenon such as fear of cold, fever in merging urinary tract infection.Acute kidney angor often makes patient's hurt like hell.
Sometimes patient does not have pain completely, only has hematuria, or blood volume is atomic, and naked eyes be can't see.When physical examination, mostly comprise uroscopy, and sediment after centrifugal by microscopy urine, if see that erythrocyte number too much just indicates hematuria, the early stage sign of renal calculus just sometimes.
First answer symptomatic treatment.Analgesic drug product while outbreak as angor, if find concurrent infection or block, should use medicine infection control as the case may be, and intra-ureteral cannula or renal pelvis fistulation if desired ensures that urine drainage is unobstructed, in order to inflammation control, prevents renal function injury.Actively find the cause of disease simultaneously, formulate treatment and prevention scheme according to heterogeneity and the cause of disease, tackle the problem at its root, prevent recurrence of hepatolithiasis as far as possible.
Sometimes there is location difficulty less, the fat patient of calculus in extracorporeal shock-wave lithotomy, position is dark, gravelstone falls into ureter and causes the problems such as obstruction after big energy-consuming, rubble, and effect is not very desirable.Surgical calculus removing is same exist larger to injury of human, the problem of the severe complication such as likely bore a hole, tear.
Therefore, need to find one and can improve calculus efficiency, can reduce or eliminate effectively, rapidly the medicine of the every disease of health that calculus causes.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of renal calculus;
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition for the treatment of renal calculus.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition for the treatment of renal calculus of the present invention, it is to be prepared from by the raw material of following weight portion:
Herba Desmodii Styracifolii 25-40 part, Spora Lygodii 15-30 part, Endothelium Corneum Gigeriae Galli 5-15 part, Radix Glycyrrhizae 4-8 part, Lignum Aquilariae Resinatum 8-15 part, Asteriscus Pseudosciaenae 12-18 part, succinum 15-25 part, Folium Pyrrosiae 15-25 part, Radix Paeoniae Alba 10-20 part, Talcum 15-25 part, Herba Dianthi 10-20 part, Semen Platycladi 8-15 part, Fructus Lycii 8-15 part;
Preferably, be to be prepared from by the raw material of following weight portion:
30 parts of Herba Desmodii Styracifolii, 20 parts of Spora Lygodii, 10 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Radix Glycyrrhizae, 10 parts of Lignum Aquilariae Resinatum, 15 parts of Asteriscus Pseudosciaenaes, 20 parts of succinums, 20 parts of Folium Pyrrosiaes, 15 parts of the Radix Paeoniae Albas, 20 parts, Talcum, 15 parts of Herba Dianthis, 10 parts of Semen Platycladi, 10 parts of Fructus Lycii.
Below crude drug source and main effect of Chinese medicine preparation of the present invention:
Herba Desmodii Styracifolii: be the dry aerial parts of leguminous plant Herba Desmodii Styracifolii Desmodium styracifoLium (Osb.) Merr..Summer, Qiu Erji tap, and remove impurity, dry.[nature and flavor with return through] are sweet, light, cool.Return liver, kidney, urinary bladder channel.[function with cure mainly] dampness removing jaundice eliminating, inducing diuresis for treating stranguria syndrome.For jaundice dark coloured urine, pyretic stranguria, stranguria caused by urinary stone, the puckery disease of urine, edema oliguria.
Spora Lygodii: be the drying and ripening spore of Lygodiaceae plant Spora Lygodii Lygodium japonicum (Thunb.) Sw..When autumn, spore did not come off, tap rattan leaf, dry, crumple or lay spore, remove rattan leaf.[nature and flavor with return through] are sweet, salty, cold.Return bladder, small intestine meridian.[function with cure mainly] eliminating damp-heat, treating stranguria pain relieving.For pyretic stranguria, stranguria caused by urinary stone, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Endothelium Corneum Gigeriae Galli: be the dry inner wall of sandbag of the chicken Gallus gallus domesticus Brisson of Phasianidae animal man.Kill after chicken, take out chicken gizzard, peel immediately inwall, cleaning, drying.[nature and flavor with return through] are sweet, flat.Return spleen, stomach, small intestinal, urinary bladder channel.[function with cure mainly] invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.
Radix Glycyrrhizae: be dry root and the rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..In the spring, Qiu Erji excavates, and removes fibrous root, dries.[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Lignum Aquilariae Resinatum: the timber that contains resin for Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum Aquilaria sinensis (Lour.) Gilg.All can gather the whole year, extracts resiniferous timber, removes not resiniferous part, dries in the shade.[nature and flavor with return through] are pungent, bitter, tepor.Return spleen, stomach, kidney channel.[function with cure mainly] promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Asteriscus Pseudosciaenae: have another name called pillow, Carnis Pseudosciaenae Shen, Shishou bone, Channa argus encephalolith, otolithum sciaenae in fish otolith, otolithum sciaenae, fish occipital bone, Shishou fish head stone, Carnis Pseudosciaenae brain.For the otolith in Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae skull, be statolith, relevant with the generation of static sense.Fish otolith is the sclerous tissues's structure in fish body internal ear semicircular duct, and its main component is mineral and small part organic substance, and its Mineral Component is carbonate.[nature and flavor] are salty, flat.[function with cure mainly] fossil, treating stranguria, antiinflammatory.Control stranguria caused by urinary stone, dysuria, otitis media, rhinitis, sinusitis with purulent discharge.
Succinum: the resin before tens million of years is buried in underground, a kind of ambrite forming after certain chemical change, is a kind of organically gel mineral.[nature and flavor with return through] are sweet, flat.GUIXIN, liver, urinary bladder channel.[function with cure mainly] tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.For malaise, palpitation and insomnia, infantile convulsion epilepsy, for blood-stasis syndrome, stranguria, the difficulty in urination.
Folium Pyrrosiae: be Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, Folium Pyrrosiae Pyrrosia Lingua (Thunb.) Farwell or pyrrosia petiolosaChing Pyrrosia petiolosa (Christ) Ching sunlight dried leaves.All can gather the whole year, removes rhizome and root, dry or cloudy in.[nature and flavor with return through] are sweet, bitter, are slightly cold.Return lung, urinary bladder channel.[function with cure mainly] inducing diuresis for treating stranguria syndrome, clearing away lung-heat to relieve cough, cooling blood for hemostasis.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, and dyspnea and cough due to lung-heat is spitted blood, epistaxis, hematuria, metrorrhagia.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put after removing crust or peeling after boiling in boiling water and boil, dry.[nature and flavor with return through] are bitter, sour, are slightly cold.Return liver, spleen channel.[function with cure mainly] nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Talcum: be silicates mineral talc family Talcum, main component is hydrous magnesium silicate [Mg3 (Si4010) (OH) 2].After excavating, remove silt and assorted stone.[nature and flavor with return through] are sweet, light, cold.Return bladder, lung, stomach warp.[function with cure mainly] inducing diuresis for treating stranguria syndrome, clearing away summer-heat, external damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.
Herba Dianthi: be the dry aerial parts of pinkwort Herba Dianthi Dianthus superbus L. or Dianthus chinensis Dianthus chinensis L..Summer, two season of autumn, flowering fruit bearing stage tapped, and removed impurity, dry.[nature and flavor with return through] hardship, cold.GUIXIN, small intestine meridian.[function with cure mainly] inducing diuresis for treating stranguria syndrome, promoting blood circulation to restore menstrual flow.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, amenorrhea stasis of blood the moon.
Semen Platycladi: be the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.The mature seed of gathering in autumn, two seasons of winter, dries, and removes seed coat, collects kernel.[nature and flavor with return through] are sweet, flat.GUIXIN, kidney, large intestine channel.[function with cure mainly] tranquilizing by nourishing the heart, loosening bowel to relieve constipation, hidroschesis.For deficiency of YIN-blood, fidgets due to deficiency insomnia, severe palpitation, dryness of the intestine constipation, night sweat due to yin deficiency.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, autumn gather when two seasons, fruit took on a red color, and hot-air seasoning, removes carpopodium, or dry in the air to rhicnosis, dry, and remove carpopodium.[nature and flavor with return through] are sweet, flat.Return liver, kidney channel.[function with cure mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains active component.
Scheme two: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, leaves standstill 12-24 hour, filters, the extractum that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains active component.
Scheme three: get whole medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 DEG C, relative density is 1.10-1.25, obtains active component.
The Chinese medicine composition for the treatment of renal calculus of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Urinary system calculus belongs to stranguria caused by urinary stone, sand Stranguria in traditional Chinese medical science gonorrhea, due to damp invasion of lower energizer, changes the scorching the moon that burns, and decocts urine, becomes sandstone, alluvial water channel, and be stranguria caused by urinary stone.Amass in next bladder qi dysfunction, it is unfavorable to urinate, very want can not, poverty-strickenly feel bad, pain extending to the lower abdomen; Be stranded in, affect the duty of kidney department urine, pent-up must not be let out down, and QI and blood is unsmooth, and stagnation of QI and blood may bring about pain is involved bladder, pudendum by kidney; It is hematuria that sandstone is hindered network.
The present invention, taking Herba Desmodii Styracifolii, Spora Lygodii as monarch drug, returns kidney, urinary bladder channel inducing diuresis for treating stranguria syndrome, pain relieving; Succinum, Lignum Aquilariae Resinatum, Folium Pyrrosiae Asteriscus Pseudosciaenae have share the merit of cooling blood for hemostasis, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain; Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, treating stranguria fossil; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, solution limb pain twin; Talcum, Herba Dianthi promoting blood circulation to restore menstrual flow, separate the hot puckery pain of urine; Semen Platycladi is flat and cold not dry, sweet in the mouth and mending, and heart kidney thoroughly, strengthening the spleen stomach, the gas that nourishes heart, profit kidney are dry; Fructus Lycii nourishing the liver and kidney; Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The collocation of full side is scientific and reasonable, meets System of Chinese medicine, mutually collaborative, makes the Chinese medicine of the present invention effect that has that good clearing away heat and promoting diuresis is treating stranguria, strengthening spleen, tonifying kidney nourishes blood.Often there is the phenomenon of suffering from a deficiency of the kidney in renal calculus patient, with the passing of time must cause gas, blood, Tianjin scarcity, and the process that insufficiency of vital energy and blood also can increase the weight of to suffer from a deficiency of the kidney increases the weight of lithiasis.Therefore when renal calculus, need take into account warming and recuperating the kidney-YANG, spleen invigorating profit temperature in treatment, synchronous therapeutic, to play the effect of clearing away heat and promoting diuresis calculus, strengthening spleen, tonifying kidney, make disease recovery from illness rapidly, cure rate is high, relapse rate is low.
A kind of Chinese medicine composition for the treatment of renal calculus provided by the invention has the following advantages:
1, Chinese medicine composition provided by the invention can effectively be treated renal calculus, the paroxysmal lumbago companion hematuria symptom after treatment, calculus being caused all improves significantly, antiinflammatory is satisfactory for result, calculus total effective rate is 93.75%, routine urianlysis result total effective rate is 91.25%, and therapeutic effect compared with prior art has significant difference (P<0.05).
2, Chinese medicine composition provided by the invention is in the time being used for the treatment of renal calculus, can significantly eliminate or slow down shiver with cold, fever, urgent micturition, frequent micturition, dysurea, lumbago, unable, hematuria, pyuria, albuminuria etc. symptom within a short period of time, reduces patient suffering.
3, Chinese medicine composition preparation method of the present invention is simple, is applicable to basic medical unit or producer and produces in enormous quantities.
Detailed description of the invention
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention instead of limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1:
Get Herba Desmodii Styracifolii 30g, Spora Lygodii 20g, Endothelium Corneum Gigeriae Galli 10g, Radix Glycyrrhizae 6g, Lignum Aquilariae Resinatum 10g, Asteriscus Pseudosciaenae 15g, succinum 20g, Folium Pyrrosiae 20g, Radix Paeoniae Alba 15g, Talcum 20g, Herba Dianthi 15g, Semen Platycladi 10g, Fructus Lycii 10g, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid,, filter the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water to stir, make syrup.
Embodiment 2:
Get Herba Desmodii Styracifolii 25g, Spora Lygodii 15g, Endothelium Corneum Gigeriae Galli 5g, Radix Glycyrrhizae 4g, Lignum Aquilariae Resinatum 8g, Asteriscus Pseudosciaenae 12g, succinum 15g, Folium Pyrrosiae 15g, Radix Paeoniae Alba 10g, Talcum 15g, Herba Dianthi 10g, Semen Platycladi 8g, Fructus Lycii 8g, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filter, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.25, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 3:
Get Herba Desmodii Styracifolii 40g, Spora Lygodii 30g, Endothelium Corneum Gigeriae Galli 15g, Radix Glycyrrhizae 8g, Lignum Aquilariae Resinatum 15g, Asteriscus Pseudosciaenae 18g, succinum 25g, Folium Pyrrosiae 25g, Radix Paeoniae Alba 20g, Talcum 25g, Herba Dianthi 20g, Semen Platycladi 15g, Fructus Lycii 15g, extracting in water 3 times, three amount of water are equivalent to respectively 12 times of medical material gross weight, 8 times, 6 times, 3 hours respectively each extraction time, 2 hours, 1 hour, merge extractive liquid, filter, the clear paste that when filtrate is concentrated into 70 DEG C, relative density is 1.20, add ethanol, making containing alcohol amount is 40%, leave standstill 24 hours, filter, the extractum that when filtrate is concentrated into 70 DEG C, relative density is 1.10, adding purified water ad pond om is 3 times of medical material gross weight, fill, obtain mixture of the present invention.
Embodiment 4:
Get Herba Desmodii Styracifolii 25g, Spora Lygodii 15g, Endothelium Corneum Gigeriae Galli 15g, Radix Glycyrrhizae 8g, Lignum Aquilariae Resinatum 8g, Asteriscus Pseudosciaenae 12g, succinum 25g, Folium Pyrrosiae 25g, Radix Paeoniae Alba 10g, Talcum 25g, Herba Dianthi 10g, Semen Platycladi 8g, Fructus Lycii 15g, with alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid,, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.10, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 5:
Get Herba Desmodii Styracifolii 40g, Spora Lygodii 15g, Endothelium Corneum Gigeriae Galli 15g, Radix Glycyrrhizae 4g, Lignum Aquilariae Resinatum 15g, Asteriscus Pseudosciaenae 12g, succinum 25g, Folium Pyrrosiae 15g, Radix Paeoniae Alba 20g, Talcum 15g, Herba Dianthi 10g, Semen Platycladi 15g, Fructus Lycii 8g, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70 DEG C, relative density is 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 6:
Get Herba Desmodii Styracifolii 30g, Spora Lygodii 30g, Endothelium Corneum Gigeriae Galli 5g, Radix Glycyrrhizae 6g, Lignum Aquilariae Resinatum 8g, Asteriscus Pseudosciaenae 12g, succinum 20g, Folium Pyrrosiae 25g, Radix Paeoniae Alba 10g, Talcum 20g, Herba Dianthi 10g, Semen Platycladi 15g, Fructus Lycii 15g, extracting in water 2 times, each amount of water is equivalent to respectively 12 times of medical material gross weight, 10 times, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, filtrate is concentrated into the clear paste that at 80 DEG C, relative density is 1.05, add ethanol, making containing alcohol amount is 70%, leave standstill 12 hours, filter, the extractum that when filtrate is concentrated into 70 DEG C, relative density is 1.25, add adjuvant Icing Sugar, starch, dextrin, ethanol, make granule.
Embodiment 7:
Take Herba Desmodii Styracifolii 30g, Spora Lygodii 20g, Endothelium Corneum Gigeriae Galli 10g, Radix Glycyrrhizae 6g, Lignum Aquilariae Resinatum 10g, Asteriscus Pseudosciaenae 15g, succinum 20g, Folium Pyrrosiae 20g, Radix Paeoniae Alba 15g, Talcum 20g, Herba Dianthi 15g, Semen Platycladi 10g, Fructus Lycii 10g, clean, pulverize, obtain powder of the present invention.
Clinical treatment is summed up
Clinical trial:
The curative effect of calculus antiinflammatory of the present invention is carried out to clinical observation, by contrast take medicine the calculus situation of Patients Before And After and treatment situation analysis calculus of the present invention, the antiinflammatory effect of inflammation.
1 diagnosis basis
1.1 waists or epigastrium continue dull pain or the violent angor of paroxysmal, are radiated to homonymy hypogastric region or pudendum, can be with being in a cold sweat, vomitting, feeling sick when angor outbreak, and bilateral has the person of blocking can have urine retention simultaneously.
1.2 can have naked eyes or microscopic hematuria, hematuria aggravation when angor outbreak.
The visible calculus shade of 1.3X line urinary system plain film great majority.
1.4 IVUs can further determine that in plain abdominal radiograph, whether calcification shadow is relevant with urinary system, can determine position, calculus place, have or not and block, and can show x-ray radioparent calculus.
1.5 INGs, B ultrasonic, CT have certain help to diagnosis.
1.6 Urinary system inflammation
1.6.1 symptom
Disease is seen shiver with cold, fever, urgent micturition, frequent micturition, dysurea, lumbago, unable, hematuria, pyuria etc., chronic phase inflammation or inflammation repeatedly show effect and can occur edema, hypertension, albuminuria etc.
1.6.2 routine urianlysis
Specific gravity of urine increases or reduction, urine protein positive, the glucose in urine positive, and microscopy finds that erythrocyte is greater than 3/HP, finds leukocyte and epithelial cell, cast etc.
2 case selections
At 30～70 years old age, be ready to accept 2 weeks therapists.
3 medicines
Experimental group: embodiment 3 mixture
Matched group: PAISHI KELI, Nanjing Tongrentang Pharmaceutical Co., Ltd.
4 curative effect index
4.1 calculus situations
Cure: clinical symptoms and sign all disappear, calculus is discharged, and color ultrasound or abdomen plain film show that hydronephrosis disappears, and calculus shade disappears;
Take a turn for the better: clinical symptom disappearance, calculus moves down, dwindles or part is discharged, and hydronephrosis disappears substantially;
Invalid: symptom is not improved, calculus is unchanged without movement or hydronephrosis.
4.2 urine routine test
Cure: clinical symptoms and sign all disappear; Urine routine test total negative;
Take a turn for the better: clinical symptom disappearance; Urine routine test has a little erythrocyte;
Invalid: symptom is not improved, urine routine test has erythrocyte, urine protein, epithelial cell;
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 140, male 77 examples, female's 63 examples; Average approximately 45 years old; All patients are all diagnosed as renal calculus through color ultrasound or the inspection of abdomen plain film, and calculus diameter is between 0.2～1.2cm, and the inspections such as routine urianlysis are made a definite diagnosis and had urinary system infection.Case is divided into two groups at random.
Therapeutic Method:
Experimental group: the embodiment of the present invention 3 mixture, are equivalent to crude drug 15g each serving consumption, three times on the one.
Matched group: PAISHI KELI, each 1 bag, three times on the one.
Experimental group and matched group, taking medicine simultaneously, strengthen amount of drinking water every day, and average daily drink amount is 3000～5000ml, takes exercises more, move as main taking jumping exercise or going upstairs, and both hands are in dorsal part intersection knocking back lumbar part.
6 results
In experimental example group case, most of patient takes after the embodiment of the present invention 3 mixture, and paroxysmal lumbago companion hematuria phenomenon reduces or disappears, and checks through color ultrasound or abdomen plain film, and calculus moves down, reduces or disappears, and therapeutic outcome is in table 1, table 2.
Table 1 renal calculus therapeutic effect
Note: with matched group comparison, * P < 0.05.
Routine urianlysis result after table 2 treatment
Note: with matched group comparison, * P < 0.05.
Interpretation of result: experimental group and matched group all have good curative effect in treatment renal calculus, the paroxysmal lumbago companion hematuria symptom after treatment, calculus being caused all improves significantly; Two groups of patients' routine urianlysis result is shown, the treatment of two groups has all obtained good effect.But experimental group and matched group relatively have significant difference.Calculus of the present invention and antiinflammatory effect are more excellent compared with matched group, have significant difference (P<0.05).Hence one can see that, and the lithagogue effect of Chinese medicine composition of the present invention and antiphlogistic effects are significantly better than prior art.
Model case:
1, what certain, man, 45 years old.Suddenly sensation painful urination, urinates not freely with lumbago and gross hematuria, routine urianlysis: erythrocyte ++, albumen+, epithelial cell ++.B ultrasonic is detected prompting: 3 pieces of right renal calculuss, diameter the maximum 0.6cm.Give the embodiment of the present invention 1 syrup, 3 times on the 1st, each 20ml.Further consultation after two weeks, patient is without lumbago, and urine is profit freely, spiritual amelioration.Check routine urinalysis: erythrocyte+, all the other feminine genders.B ultrasonic reports that right kidney is shown in 1 piece, calculus.Continue to take two weeks, every day, amount of drinking water was about 4000ml, further consultation result: patient's private prosecution is without discomfort, the limpid smooth profit of urine, and thready and rolling pulse, light red tongue, white and thin fur, checks routine urinalysis, B ultrasonic is detected equal to abnormal again.
2, Zhao, man, 63 years old.Unbearably, there is hematuria in prominent sense lumbago, dysuria, through the routine that has urine examined: erythrocyte +++, albumen+, epithelial cell ++, B ultrasonic is detected 2 pieces of the left renal calculuss of prompting, diameter 0.8cm.Give the embodiment of the present invention 4 tablets, 3 times on the 1st, each 6.And coordinate jump action and day drink boiled water 4000ml left and right, and after taking medicine 1 week, all diseases disappear, and urine is normal, discharges 1 piece, calculus when the 8th day urine, and diameter 0.5cm discharges one piece, calculus, diameter 0.7cm on the 10th day again.Within the 12nd day, check routine urinalysis is normal, and B ultrasonic is detected and pointed out two kidneys, ureter, bladder to be showed no calculus.
Although, above use general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. the Chinese medicine composition for the treatment of renal calculus, is characterized in that it is to be prepared from by the raw material of following weight portion: Herba Desmodii Styracifolii 25-40 part, Spora Lygodii 15-30 part, Endothelium Corneum Gigeriae Galli 5-15 part, Radix Glycyrrhizae 4-8 part, Lignum Aquilariae Resinatum 8-15 part, Asteriscus Pseudosciaenae 12-18 part, succinum 15-25 part, Folium Pyrrosiae 15-25 part, Radix Paeoniae Alba 10-20 part, Talcum 15-25 part, Herba Dianthi 10-20 part, Semen Platycladi 8-15 part, Fructus Lycii 8-15 part.
2. Chinese medicine composition according to claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion: 30 parts of Herba Desmodii Styracifolii, 20 parts of Spora Lygodii, 10 parts of Endothelium Corneum Gigeriae Galli, 6 parts, Radix Glycyrrhizae, 10 parts of Lignum Aquilariae Resinatum, 15 parts of Asteriscus Pseudosciaenaes, 20 parts of succinums, 20 parts of Folium Pyrrosiaes, 15 parts of the Radix Paeoniae Albas, 20 parts, Talcum, 15 parts of Herba Dianthis, 10 parts of Semen Platycladi, 10 parts of Fructus Lycii.
3. Chinese medicine composition as claimed in claim 1 or 2, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.
5. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, leave standstill 12-24 hour, filter, the extractum that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.
6. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 DEG C, relative density is 1.10-1.25, obtains described active component.
7. the Chinese medicine composition for the treatment of renal calculus, prepared into acceptable carrier in pharmaceuticals industry by the Chinese medicine composition for the treatment of renal calculus described in claim 1 or 2.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412248A (en) * | 2015-11-27 | 2016-03-23 | 梁小琼 | Traditional Chinese medicine composition for treating calculus and preparation method thereof |
| CN105412286A (en) * | 2015-11-27 | 2016-03-23 | 梁小琼 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
| CN107375350A (en) * | 2017-08-23 | 2017-11-24 | 赵庆春 | Clear stone Chinese medicine composition and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480203A (en) * | 2003-08-05 | 2004-03-10 | 王宝林 | Preparation of Chinese herbal medicine to be taken after being mixed with boiling water for removal of urinary calculus |
| CN1742904A (en) * | 2005-09-29 | 2006-03-08 | 广西梧州三鹤药业有限公司 | Chinese medicine for treating urinary stone and urinary system inflammation, and production method thereof |
| CN101317890A (en) * | 2008-07-17 | 2008-12-10 | 洛阳梓生科技开发有限公司 | Process for preparing capsule for urinary system lithiasis |
| CN103735640A (en) * | 2013-12-07 | 2014-04-23 | 丛辉 | Calculus-removing traditional Chinese medicine formula |
| CN103860659A (en) * | 2014-04-06 | 2014-06-18 | 王颖慧 | Traditional Chinese medicine for treating early nephrolith |
-
2014
- 2014-09-15 CN CN201410469380.3A patent/CN104189267A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480203A (en) * | 2003-08-05 | 2004-03-10 | 王宝林 | Preparation of Chinese herbal medicine to be taken after being mixed with boiling water for removal of urinary calculus |
| CN1742904A (en) * | 2005-09-29 | 2006-03-08 | 广西梧州三鹤药业有限公司 | Chinese medicine for treating urinary stone and urinary system inflammation, and production method thereof |
| CN101317890A (en) * | 2008-07-17 | 2008-12-10 | 洛阳梓生科技开发有限公司 | Process for preparing capsule for urinary system lithiasis |
| CN103735640A (en) * | 2013-12-07 | 2014-04-23 | 丛辉 | Calculus-removing traditional Chinese medicine formula |
| CN103860659A (en) * | 2014-04-06 | 2014-06-18 | 王颖慧 | Traditional Chinese medicine for treating early nephrolith |
Non-Patent Citations (4)
| Title |
|---|
| 姜林嵩等: "金海石合剂的制备及临床观察", 《光明中医》 * |
| 李敏主编: "《中药材规范化生产与管理 GAP 方法及技术》", 31 January 2005, 中国医药科技出版社 * |
| 陆安锠: "自拟化瘀排石汤治疗泌尿系结石34例", 《河南中医药学刊》 * |
| 陈少林主编: "《宗言顺医疗实践录》", 31 August 2013, 军事医学科学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412248A (en) * | 2015-11-27 | 2016-03-23 | 梁小琼 | Traditional Chinese medicine composition for treating calculus and preparation method thereof |
| CN105412286A (en) * | 2015-11-27 | 2016-03-23 | 梁小琼 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
| CN107375350A (en) * | 2017-08-23 | 2017-11-24 | 赵庆春 | Clear stone Chinese medicine composition and preparation method thereof |
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