CN104147540A - Traditional Chinese medicine composition for treating malignant tumor - Google Patents
Traditional Chinese medicine composition for treating malignant tumor Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating malignant tumor. The traditional Chinese medicine composition is prepared from following raw materials, by weight: 5-12 parts of radices trichosanthis, 1-3 parts of rhizoma sparganic, 1-3 parts of zedoary, 3-5 parts of peach kernel, 3-5 parts of safflower, 1-2 parts of prepared semen strychni, 1-3 parts of ground beetles, 2-5 parts of scorpions, 1-3 parts of centipedes, 3-5 parts of pinellia ternate, 1-2 parts of arisaema consanguineum schott, 3-5 parts of frankincense, 3-8 parts of sappanwood, 5-8 parts of achyranthes bidentata, 5-8 parts of hawthorns, 8-12 parts of radix codonopsis and 10-20 parts of astragalus. The traditional Chinese medicine composition has effects of tonifying qi and activating blood, dispelling stasis and removing toxin, resolving phlegm, dissipating binds and dispersing swelling. The traditional Chinese medicine composition has advantages of being significant in curative effects, having effects on both exterior and interior, being slight in toxic and side effects on treatment of malignant tumor in spleen deficiency, blood stasis and phlegm evil types.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of malignant tumor, concrete, relate to a kind of Chinese medicine composition for the treatment of spleen deficiency and blood stasis phlegm stagnation syndrome type malignant tumor, belong to technical field of Chinese medicines.
Background technology
Malignant tumor has the character of " deficiency in origin and excess in superficiality ", and deficiency in origin i.e. " the positive deficiency of vital energy ", often show as weak, appetite is poor, weight loss, immunity are poor etc.; Mark real i.e. " excess of pathogen ", often show as clinically complexion dirty dark, purplish tongue is dark, thick fur is greasy, stringy and hesitant pulse etc.Initial stage is taking the domination of pathogen as main, and middle and advanced stage is taking weakened body resistance as main, has void, wet, expectorant, the stasis of blood, the poison feature of knot mutually on pathology.Mostly be spleen deficiency and blood stasis phlegm stagnation syndrome type for advanced malignant tumor at present, mostly its treatment is to adopt the direct treatment of simple antitumor drug, wherein, treatment by Chinese herbs, often use antipyretic and antidotal type medicine, the most impairing the spleen and stomach of these medicines, side effect is larger, although often poor effect of compatibility tonification medicine.Western medicine often adopts chemicotherapy, and the bone marrow to human body and immune infringement are larger.Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of malignant tumor, curative effect obviously, treating both the principal and secondary aspects of a disease, toxic and side effects be little.
For achieving the above object, the present invention adopts following technical proposals:
Treating a Chinese medicine composition for malignant tumor, is to be made up of the raw material of following weight parts:
Radix Trichosanthis 5-12 part, Rhizoma Sparganii 1-6 part, Rhizoma Curcumae 1-10 part, Semen Persicae 3-8 part, Flos Carthami 3-8 part, Semen Strychni (processed) 1-2 part, eupolyphaga 1-8 part, Scorpio 2-6 part, Scolopendra 1-3 part, Rhizoma Pinelliae 3-9 part, Rhizoma Arisaematis 1-10 part, Olibanum 3-5 part, Lignum Sappan 3-8 part, Radix Achyranthis Bidentatae 5-10 part, Fructus Crataegi 5-8 part, Radix Codonopsis 8-15 part, Radix Astragali 10-20 part.
The Chinese medicine composition of this treatment malignant tumor, preferred medicament composing prescription is:
12 parts of Radix Trichosanthis, 6 parts of Rhizoma Sparganii, 10 parts of Rhizoma Curcumae, 6 parts, Semen Persicae, 6 parts, Flos Carthami, 1 part of Semen Strychni (processed), 8 parts of eupolyphaga, 6 parts of Scorpios, 2 parts of Scolopendras, 9 parts of the Rhizoma Pinelliaes, 10 parts of Rhizoma Arisaematiss, 3 parts of Olibanums, 8 parts of Lignum Sappans, 10 parts of Radix Achyranthis Bidentataes, 8 parts of Fructus Crataegis, 15 parts of Radix Codonopsis, 15 parts of the Radixs Astragali.
The Chinese medicine composition of this treatment malignant tumor, another preferred medicament composing prescription is:
8 parts of Radix Trichosanthis, 2 parts of Rhizoma Sparganii, 2 parts of Rhizoma Curcumae, 6 parts, Semen Persicae, 6 parts, Flos Carthami, 1 part of Semen Strychni (processed), 2 parts of eupolyphaga, 2 parts of Scorpios, 2 parts of Scolopendras, 3 parts of the Rhizoma Pinelliaes, 1 part of Rhizoma Arisaematis, 3 parts of Olibanums, 8 parts of Lignum Sappans, 8 parts of Radix Achyranthis Bidentataes, 6 parts of Fructus Crataegis, 10 parts of Radix Codonopsis, 15 parts of the Radixs Astragali.
Radix Trichosanthis in prescription, Rhizoma Sparganii, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Scorpio, Scolopendra, the Rhizoma Pinelliae, Rhizoma Arisaematis, Olibanum, Lignum Sappan, Radix Achyranthis Bidentatae, Fructus Crataegi, Radix Codonopsis, the Radix Astragali 15 taste crude drugs are the kind that " Chinese Pharmacopoeia " (version in 2010) recorded, and its quality all meets the regulation under each kind item.
Eupolyphaga: be the female worm dry body of Corydiidae insecticide eupolyphoge sinensis (Eupolyphagasinensis Walker) or Ji eupolyphoge sinensis (Steleophaga Plancyi).
Semen Strychni (processed): being commercially available prod, is that Semen Strychni is put into pot heating, stir-fried, until Semen Strychni surface becomes yellowish-brown.
The preparation method of this Chinese medicine composition is: get above-mentioned raw materials by the weight portion in prescription, water (w/v that is raw material and water is 1g:3-5ml) the merceration 30-60 minute doubly measuring with 3-5, be heated to boiling, decoct 30-60 minute, leach medicinal liquid, the water that adds again 2-4 doubly to measure in medicinal residues, decocts 20-40 minute, merges twice decoction liquor.
Gained decoction liquor can be directly as decoction oral, and take after the meal every day sooner or later, each 400mL, and taking continuously 4 weeks is a course for the treatment of.
Gained decoction liquor can also further concentrate and obtain extractum, adds adjuvant, makes capsule, tablet, granule or pill with conventional method.
The adjuvant adding is the mannitol of item level, lactose, starch, magnesium stearate, saccharin sodium, cellulose or magnesium carbonate.
Below the detailed description of raw material of Chinese medicine in prescription:
Wherein, Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature, attaches to the lung and stomach meridians.There is clearing away heat and promoting production of body fluid, the effects such as detumescence and apocenosis.Cure mainly calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin etc.Modern pharmacological research show Radix Trichosanthis have the miscarriage of causing and antiearly pregnancy, anticancer, increase the effects such as body's immunity, antibacterial and antiviral.
Rhizoma Sparganii: acrid in the mouth, puckery, cool in nature, return liver, spleen channel.There is removing blood stasis circulation of qi promoting, the effects such as removing food stagnancy pain relieving.Cure mainly lump in the abdomen mass in the abdomen, the stagnant amenorrhea of the stasis of blood, dysmenorrhea, food stagnation distending pain, falls year pain of injury etc.Modern pharmacological research and clinical practice report show that Rhizoma Sparganii has anti-platelet aggregation and antithrombotic; reduce whole blood viscosity; analgesia, arteriosclerosis, antitumor; cause premature labor; and protection hepatocyte, alleviate hepatocellular degeneration necrosis, recover hepatocyte structure and function; reduce fibrosis development, promote the effects such as fibrous tissue degraded.
Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature, return liver, spleen channel.There is circulation of qi promoting removing blood stasis, the effects such as removing food stagnancy pain relieving.Cure mainly lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, early cervical carcinoma etc.Modern pharmacological research and clinical practice report shows that Rhizoma Curcumae has antiviral, antibacterial, antitumor, antalgic and inflammation relieving, antiplatelet aggregation, anticoagulation and regulates the effects such as hemorheological property, anti-proliferation of fibrous tissue, antiearly pregnancy.
Semen Persicae: bitter in the mouth, sweet, property is flat, GUIXIN, liver, large intestine, lung, spleen channel.There is blood stasis removing and clots absorbing, moisturize the effects such as laxation.Cure mainly amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood etc.Modern pharmacological research shows that Semen Persicae has blood vessel dilating, increases organic blood flow volume, anticoagulant, anticoagulation, prevents thrombosis, fibrinolysis enhancing, improves hemorheological property, improves liver surface microcirculation, resists myocardial ischemia, analgesia, anti-hepatic fibrosis, loosening bowel to relieve constipation, antiinflammatory, antitussive, antitumor, antibacterial, and Semen Persicae (parched) total protein can improve the effects such as humoral immunity of organism function.
Flos Carthami: acrid in the mouth, warm in nature, GUIXIN, Liver Channel.Have that invigorate blood circulation can be through, the effects such as stasis-dispelling and pain-killing.Cure mainly amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down etc.Modern pharmacological research shows that Flos Carthami has excited uterus, reduces blood pressure, blood fat, and anticoagulation, thrombosis, antiinflammatory, analgesia and calm, defying age, protects the liver, anti allergic reaction; Animal experiment shows: low dose of Flos Carthami decoct has slight excitation to Bufo siccus heart, makes that heart beating is strong, amplitude strengthens, useful to myocardial ischemia; Heavy dose of have inhibitory action on the contrary to Bufo siccus, and expansion body hat tremulous pulse and femoral artery; There is the spasm of removing vascular smooth muscle, make tissue obtain hemoperfusion, improve histanoxia state and strengthen hypoxia-bearing capability, stop thrombosis to further develop and the progressively effect such as thrombus, reduction cholesterol.
Semen Strychni (processed): bitter in the mouth, warm in nature, return liver, spleen channel.There is removing obstruction in the collateral to relieve pain, the effects such as mass dissipating and swelling eliminating.Be mainly used in rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain, poliomyelitis sequela, rheumatoid arthritis etc.Modern pharmacological research shows that Semen Strychni has tumor, analgesia, the antitussive of inhibition, eliminates the phlegm, relievings asthma, the effect such as antibacterial; to secondary inflammation, reaction has obvious inhibitory action to strychnine 8～16mg/kg dosage; immune organ weight is had no significant effect; strychnine and nitrogen oxide thereof have protective effect to myocardial cell; the antithrombotic formation of vivo medicine-feeding energy; Semen Strychni nitrogen oxide and Semen Strychni are conducive to improve microcirculation, increase the effects such as blood flow.
Eupolyphaga: salty in the mouth, cold in nature, return Liver Channel.There is removing blood stasis with potent drugs blood, the effects such as reuniting the fractured tendons and bones.Be mainly used in injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen etc.Modern pharmacological research shows that eupolyphaga has anticoagulation and antithrombotic; regulate blood fat; antioxidant radical and protection vascular endothelial cell; reduce whole blood viscosity and plasma fibrinogen; suppress thrombosis; anticoagulant; and can increase erythrocyte surface electric charge; improve erythrocyte deformability, reduce hematocrit, high viscosity, low viscosity, erythrocyte aggregation index, Rigidity of red cells index, the ischemia resisting anoxia of cutting of whole blood of cutting of whole blood; suppress angiogenesis and anti-tumor activity; mutation, treatment trauma fracture, improves the effects such as immune system.
Scorpio: acrid in the mouth, property is flat, returns Liver Channel.There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, the effects such as removing obstruction in the collateral to relieve pain.Be mainly used in infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula etc.Modern pharmacological research shows that Scorpio has analgesia, anticancer, epilepsy, convulsion, suppresses the effects such as nonspecific immunity and humoral immune function, and scorpion extraction liquid can be by promoting fibrinolytic, anticoagulant to suppress thrombosis, scorpion venom can produce uterine contraction, and causes early abortion.
Scolopendra: acrid in the mouth, warm in nature, return Liver Channel.There is endogenous wind stopping spasmolytic, merit poison eliminating stagnation, the effects such as removing obstruction in the collateral to relieve pain.Be mainly used in infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.Modern pharmacological research and clinical practice report show that Scolopendra has calmness, analgesia, spasmolytic and antiinflammatory; improve immunologic function; regulate lipid metabolism, improve hemorheology, reduce blood fat, strengthen myocardium oxidation resistance and protect cardiac muscle to avoid lipid peroxidation injury, protection vascular endothelial cell is avoided damage, effectively prevents and treats atherosclerotic formation; improve myocardial ischemia; increase coronary flow, strengthen gastrointestinal function, maincenter suppresses and anticonvulsant action; antitumor, kills the effects such as embryo.
The Rhizoma Pinelliae: acrid in the mouth, warm in nature, return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effects such as dissolving lump and resolving mass.Be mainly used in abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus etc.Modern pharmacological research and clinical practice report show that Scolopendra has antitussive, eliminate the phlegm, and preventing or arresting vomiting, press down cancer, suppress central nervous system, there is analgesia, calmness, syngignoscism to a certain degree, there is antiinflammatory, antiviral, stop or delay the effects such as the formation of bait hyperlipemia.
Rhizoma Arisaematis: bitter in the mouth, pungent, warm in nature, return lung, liver, spleen channel.There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, the effects such as mass dissipating and swelling eliminating.Be mainly used in pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus etc.Modern pharmacological research shows that Rhizoma Arisaematis has antitumor, and antiinflammatory, antibacterial, eliminates the phlegm, calm, analgesia, and convulsion, delays arrhythmia time of occurrence, shortens the arrhythmia persistent period, antioxidation, the effects such as anticoagulation.
Olibanum: acrid in the mouth, hardship, slightly warm in nature, GUIXIN, liver, spleen channel.There is blood-activating and qi-promoting, inducing menstruation to relieve menalgia, the effects such as detumescence and promoting granulation.Cure mainly trusted subordinate's pain, rheumatic arthralgia, amenorrhea dysmenorrhea, traumatic injury stasis of blood pain, swollen ulcer drug, acute appendicitis, the sore being festered and unhealed etc.Modern pharmacological research shows that Olibanum has analgesia, antiinflammatory, antibacterial, and antitumor, anti-gastric-ulcer, antioxidation, improves the effects such as memory.
Lignum Sappan: sweet in the mouth, salty, property is flat, GUIXIN, liver, stomach, large intestine channel.There is blood circulation promoting and blood stasis dispelling, the effects such as subduing swelling and relieving pain.Be mainly used in married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus etc.Modern pharmacological research shows that Lignum Sappan has antitumor, immunosuppressant, anti-inflammation, antioxidation, blood sugar lowering, diastole aorta, the effects such as hypnosis.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat, returns liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, draws blood (fire) descending, the effects such as inducing diuresis for treating stranguria syndrome.Be mainly used in soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain etc.Modern pharmacological research shows that Radix Achyranthis Bidentatae has enhancing immunoregulation capability, uteri excitation effect and antifertility action, tumor inhibition effect, antiinflammatory, antibacterial and analgesic activity, improve memory, endurance and anti-aging effects, the effect of blood pressure lowering, arteriosclerosis, reduction thrombosis length, weight in wet base and dry weight, reduces platelet and builds up property, improves erythrocyte deformability, reduces the effect of fibrinogen level, anti-gastric-ulcer, the effects such as osteoporosis.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, liver, lung meridian.Have and help digestion long-pendingly, change the effects such as the stagnant stasis of blood.Be mainly used in eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea etc.Modern pharmacological research and clinical practice show that Fructus Crataegi has blood pressure lowering, increase coronary flow, resist myocardial ischemia; treating cerebral ischemia, anti-arrhythmia, positive inotropic; heart tonifying, blood fat reducing, protection human vascular endothelial; antiplatelet aggregation, antibacterial, antitumor; resisting fatigue, pain relieving, hemostasis; aid digestion, diuresis, the effects such as preventing phlegm from forming and stopping coughing.
Radix Codonopsis: sweet in the mouth, property is flat, returns spleen, lung meridian.There is strengthening the spleen and tonifying the lung, the effects such as supplementing QI for promoting the production of body fluid.Be mainly used in weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, all cards of QIYINLIANGXU.Modern pharmacological research shows that Radix Codonopsis has adjusting blood glucose; Promote hematopoietic function, the caused leukopenia of chemotherapy lonizing radiation is had to castering action, can make a rabbit erythrocyte and hemoglobin increase; Blood pressure lowering; Anti-hypoxia, endurance, enhancing human body immunity power; Regulate stomach to shrink and antiulcer, protection gastric mucosa; Improve memory ability; Strengthen left chamber contractile function and cardiac output, but heart rate is without change; Anticoagulant; The effects such as excitor nerve system.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Return lung, spleen channel.There is benefit and defend consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting, the effects such as invigorating the spleen and replenishing QI.Be mainly used in spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and do not hold back for a long time, internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, gas tiger blood prostration, metrorrhagia and leukorrhagia, and the card of all weakness of QI blood deficiency.Modern pharmacological research and clinical practice show that the Radix Astragali has myocardium positive inotropic action, protection hypoxic-ischemic cardiac muscle, protection viral infection cardiac muscle, two-ways regulation blood pressure; enhancing immunity, antiviral, anticancer, defying age; antiplatelet aggregation, diuresis, the effects such as protection hepatic injury.
Inventor notices that in clinical practice much gestation forbidding Chinese medicine and induced abortion Chinese medicine have again antineoplastic action simultaneously, as Radix Achyranthis Bidentatae, Rhizoma Curcumae, Radix Trichosanthis etc. have the embryo of killing, antitumor dual function, and tumor cell and body early embryo are at gene, protein, metabolism, the aspects such as proliferation and differentiation have similarity, therefore the gestation forbidding medicine for the treatment of ectopic pregnancy and the thinking of induced abortion treatment by Chinese herbs tumor for creationary proposition, kill in the induced abortion that is used for the treatment of ectopic pregnancy on the basis of embryo side, through reasonable compatibility, obtain " anti-spleen deficiency and blood stasis phlegm stagnation syndrome type malignant tumor side ", for the clinical treatment of malignant tumor, obtain significant curative effect.
Medication thought of the present invention is:
Widely apply the Radix Astragali as monarch drug, with invigorating the spleen and replenishing QI; Taking Radix Codonopsis, Radix Trichosanthis as ministerial drug, strengthen the power of QI invigorating, yin nourishing; Assistant is with Rhizoma Sparganii, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Semen Strychni (processed), eupolyphaga, the Rhizoma Pinelliae, Rhizoma Arisaematis, Olibanum, Lignum Sappan, Radix Achyranthis Bidentatae, Fructus Crataegi, and with blood circulation promoting and blood stasis dispelling, dissipating phlegm and resolving masses, promoting the circulation of QI to relieve pain, removing toxic substances is gone turbid; Taking Scorpio as assistant, Scolopendra are for making, both can make medicine go deep into inside tumor, there is again the merit of blood circulation promoting and blood stasis dispelling.All medicines share, and play altogether inrigorating qi and promoting blood circulation, blood stasis dispelling removing toxic substances, the merit of dissipating phlegm and resolving masses detumescence, treating both the principal and secondary aspects of a disease.
Beneficial effect of the present invention:
The present invention has expanded medication consideration, the Chinese medicinal formulae obtaining according to this medication consideration has inrigorating qi and promoting blood circulation, blood stasis dispelling removing toxic substances, effect of dissipating phlegm and resolving masses detumescence, for the treatment of spleen deficiency and blood stasis phlegm stagnation syndrome type malignant tumor have curative effect obviously, the advantage such as treating both the principal and secondary aspects of a disease, toxic and side effects be little.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only in order to explain the present invention, does not limit its content.
Embodiment 1
Treating a Chinese medicine composition for malignant tumor, is to be made up of the raw material of following weight parts:
12 grams of Radix Trichosanthis, 6 grams of Rhizoma Sparganii, 10 grams of Rhizoma Curcumae, 6 grams, Semen Persicae, 6 grams, Flos Carthami, 1 gram of Semen Strychni (processed), 8 grams of eupolyphaga, 6 grams of Scorpios, 2 grams of Scolopendras, 9 grams of the Rhizoma Pinelliaes, 10 grams of Rhizoma Arisaematiss, 3 grams of Olibanums, 8 grams of Lignum Sappans, 10 grams of Radix Achyranthis Bidentataes, 8 grams of Fructus Crataegis, 15 grams of Radix Codonopsis, 15 grams of the Radixs Astragali.
Above-mentioned raw materials is provided by Shandong ProvinceQianfoshan Hospital Chinese medicine pharmacy.
Preparation method: get above-mentioned raw materials, add water 400 milliliters, soak 30 minutes, intense fire adjusts slow fire to boil 30 minutes to water boiling, pours out after medicinal liquid, again adds water 300 milliliters, decocts 20 minutes, removes medicinal residues.Merge medicinal liquid twice, to obtain final product.
Embodiment 2
Treating a Chinese medicine composition for malignant tumor, is to be made up of the raw material of following weight parts:
8 grams of Radix Trichosanthis, 2 grams of Rhizoma Sparganii, 2 grams of Rhizoma Curcumae, 6 grams, Semen Persicae, 6 grams, Flos Carthami, 1 gram of Semen Strychni (processed), 2 grams of eupolyphaga, 2 grams of Scorpios, 2 grams of Scolopendras, 3 grams of the Rhizoma Pinelliaes, 1 gram of Rhizoma Arisaematis, 3 grams of Olibanums, 8 grams of Lignum Sappans, 8 grams of Radix Achyranthis Bidentataes, 6 grams of Fructus Crataegis, 10 grams of Radix Codonopsis, 15 grams of the Radixs Astragali.
Above-mentioned raw materials is provided by Shandong ProvinceQianfoshan Hospital Chinese medicine pharmacy.
Preparation method: get above-mentioned raw materials, add water 400 milliliters, soak 30 minutes, intense fire adjusts slow fire to boil 30 minutes to water boiling, pours out after medicinal liquid, again adds water 300 milliliters, decocts 20 minutes, removes medicinal residues.Merge medicinal liquid twice, to obtain final product.
Embodiment 3
Treating a Chinese medicine composition for malignant tumor, is to be made up of the raw material of following weight parts:
10 grams of Radix Trichosanthis, 1 gram of Rhizoma Sparganii, 1 gram of Rhizoma Curcumae, 5 grams, Semen Persicae, 5 grams, Flos Carthami, 1 gram of Semen Strychni (processed), 2 grams of eupolyphaga, 3 grams of Scorpios, 1 gram of Scolopendra, 5 grams of the Rhizoma Pinelliaes, 2 grams of Rhizoma Arisaematiss, 4 grams of Olibanums, 6 grams of Lignum Sappans, 6 grams of Radix Achyranthis Bidentataes, 6 grams of Fructus Crataegis, 12 grams of Radix Codonopsis, 20 grams of the Radixs Astragali.
Above-mentioned raw materials is provided by Shandong ProvinceQianfoshan Hospital Chinese medicine pharmacy.
Preparation method: get above-mentioned raw materials, add water 450 milliliters, soak 50 minutes, intense fire adjusts slow fire to boil 30 minutes to water boiling, pours out after medicinal liquid, again adds water 350 milliliters, decocts 40 minutes, removes medicinal residues.Merge medicinal liquid twice, medicinal liquid concentrating under reduced pressure obtains extractum, adds supplementary product starch and magnesium stearate, makes capsule with conventional method, and specification is 0.3g/ grain, and consumption is every day three times, each 4.
Embodiment 4
Treating a Chinese medicine composition for malignant tumor, is to be made up of the raw material of following weight parts:
5 grams of Radix Trichosanthis, 3 grams of Rhizoma Sparganii, 1 gram of Rhizoma Curcumae, 5 grams, Semen Persicae, 3 grams, Flos Carthami, 2 grams of Semen Strychni (processed)s, 1 gram of eupolyphaga, 5 grams of Scorpios, 1 gram of Scolopendra, 5 grams of the Rhizoma Pinelliaes, 1 gram of Rhizoma Arisaematis, 5 grams of Olibanums, 3 grams of Lignum Sappans, 8 grams of Radix Achyranthis Bidentataes, 5 grams of Fructus Crataegis, 12 grams of Radix Codonopsis, 10 grams of the Radixs Astragali.
Above-mentioned raw materials is provided by Shandong ProvinceQianfoshan Hospital Chinese medicine pharmacy.
Preparation method: get above-mentioned raw materials, add water 400 milliliters, soak 60 minutes, intense fire adjusts slow fire to boil 30 minutes to water boiling, pours out after medicinal liquid, again adds water 300 milliliters, decocts 40 minutes, removes medicinal residues.Merge medicinal liquid twice, medicinal liquid concentrating under reduced pressure obtains extractum, adds supplementary product starch and magnesium stearate, makes tablet with conventional method, and specification is 0.3g/ sheet, and consumption is every day three times, each 4.
Embodiment 5
Treating a Chinese medicinal formulae for malignant tumor, is to be made up of the raw material of following weight parts:
12 grams of Radix Trichosanthis, 1 gram of Rhizoma Sparganii, 3 grams of Rhizoma Curcumae, 3 grams, Semen Persicae, 5 grams, Flos Carthami, 1 gram of Semen Strychni (processed), 3 grams of eupolyphaga, 2 grams of Scorpios, 3 grams of Scolopendras, 3 grams of the Rhizoma Pinelliaes, 2 grams of Rhizoma Arisaematiss, 3 grams of Olibanums, 8 grams of Lignum Sappans, 5 grams of Radix Achyranthis Bidentataes, 8 grams of Fructus Crataegis, 8 grams of Radix Codonopsis, 20 grams of the Radixs Astragali.
Above-mentioned raw materials is provided by Shandong ProvinceQianfoshan Hospital Chinese medicine pharmacy.
Preparation method is with embodiment 1.
Clinical data
55 routine late tumor patients all come from the in-patient department of in June, the 2011～2012 year December Shandong ProvinceQianfoshan Hospital department of Chinese medicine, change, radiotherapy department, adopt table of random number method to be divided into treatment group, matched group.Treatment group 29 examples, male's 15 examples, women's 14 examples; The median age 60.11 years old; Lesions position: lung 9 examples, stomach 5 examples, knot rectum 2 examples, pancreas 2 examples, mammary gland 3 examples, endometrium 1 example, ovary 3 examples, kidney 1 example, the esophageal carcinoma 3 examples; Matched group 26 examples, male's 15 examples, women's 11 examples; The median age 59.78 years old; Lesions position: lung 7 examples, stomach 3 examples, knot rectum 3 examples, pancreas 3 examples, mammary gland 3 examples, endometrium 2 examples, ovary 2 examples, kidney 1 example, the esophageal carcinoma 2 examples.All patients all have clear and definite histopathology diagnosis; >=40 points of Karnofsky scorings, routine blood test, hepatic and renal function and electrocardiogram normal, image analysis all has measurable focus, estimates life cycle and is greater than March.2 groups of physical data comparisons, no significant difference (P ﹥ 0.05), has comparability.
Therapeutic Method
Matched group: thymopentin for injection (tp-5) (the by name and letter of commodity, specification 1mg/ props up, Hainan Zhonghe Medicine Co., Ltd produces) is dissolved in to intramuscular injection after 1ml sterilized water for injection, 1mg/d.
Treatment group: the Chinese medicine preparation that adopts the embodiment of the present invention 1 to prepare, oral, each 1 time sooner or later, each 400ml.
Two groups all taking 4 weeks as 1 course for the treatment of, and Continuous Observation carries out curative effect evaluation after 2 courses for the treatment of.
Observation index and efficacy determination
Treat latter 1 day respectively at first 1 day of begin treatment and end, respectively two groups of patients are evaluated, observe its situation of change.
1.KPS scoring and body weight
Karnofsky (KPS) criterion: increase >=10 is divided into increases, reduces >=10 and is divided into reduction, increases or reduces ﹤ 10 and be divided into stable.
Body weight criterion: before and after treatment, body weight increase >=1kg is for increasing, and minimizing >=1kg, for reducing, increases or reduce ﹤ 1kg for stable.
2. immunologic function
Select the observation index of t lymphocyte subset group (CD3, CD4, CD8, CD4/CD8) as changes in immune function before and after treatment.Detecting instrument adopts the U.S. Epics XL of Beckman Coulter company flow cytometer to detect; Range of normal value CD3:61.1～77.0%, CD4:25.8～45.6%, CD8:18.1～29.6%, CD4/CD8:1.57～2.93%.
3. coagulation function
The observation index of selecting plasma fibrinogen (Fib), prothrombin time (PT) to change as coagulation function.Adopt Sysmex CA7000 full-automatic blood coagulation analyzer to detect; Range of normal value Fib:1.8～3.5g/L, PT:9.8～12.1s.
4. the recent objective curative effect of tumor
CT examination is observed the change of quantity and the size of malignant tumor patient focus.Short term effect standard is according to WHO standard: alleviate completely (CR): all target foci disappearances, at least maintain more than 4 weeks; Partial rcsponse (PR): baseline focus major diameter summation dwindles >=and 30%; Stable (SD): baseline focus major diameter summation has to dwindle but do not reach PR or have to be increased but do not reach PD; Progress (PD): baseline focus major diameter summation increases >=20% or occur new focus; CR+PR is effective (RR).Statistical method
All data statistic analysis are all used SPSS18.0 version, quantitative data with mean ± standard deviation (
) represent, in group, relatively adopt paired t-test, between group, relatively adopt the t inspection of independent sample, the evaluation of enumeration data, adopts X 2 test, and ranked data are analyzed with Ridit.
Result of study
1.KPS scoring and weight ratio are
14 examples are increased in treatment group KPS scoring, stablize 12 examples, reduce by 3 examples; Matched group increases 10 examples, stablizes 11 examples, reduces by 5 examples, and through X 2 test, two groups exist significant difference (P < 0.05).
Treatment group body weight increases 11 examples, stablizes 14 examples, reduces by 2 examples, and matched group group body weight increases 3 examples, stablizes 15 examples, reduces by 6 examples, and treatment group curative effect is better than matched group, and through X 2 test, two groups exist significant difference (P < 0.05).2. liang group immunologic function comparison
In table 1.
Immunologic function detection index comparison before and after table 1 liang group treatment (
)
Note: compare between group after two groups of treatments
*p < 0.05; Before and after two groups of treatments, in group, compare
△p < 0.05.
3. liang group coagulation function comparison
In table 2.
Blood Coagulation comparison before and after table 2 liang group treatment (
)
Note: compare between group after two groups of treatments
*p < 0.05; Before and after two groups of treatments, in group, compare
△p < 0.05.
4. liang recent objective curative effect comparison of group tumor
After treatment finishes, treatment group CR0 example, PR9 example, SD18 example, PD2 example; Matched group CR0 example, PR5 example, SD15 example, PD6 example.Two groups of recent objective curative effects are compared, and the objective curative effect effective percentage of tumor (the total number of cases of CR+PR/) for the treatment of group is 31.03%, higher than 19.23%, two group of no significant difference of matched group (P ﹥ O.05).
Model case:
Case 1: Liu so-and-so, man, 64 years old, pulmonary carcinoma, CT shows superior lobe of right lung lung cancer accompanied right side a large amount of hydrothorax, and occurs inferior lobe limitation atelectasis, superior lobe of left lung apicoposterior segment fibroid induration kitchen range in right lung.The treatments such as capable operation and chemicotherapy.Symptoms including cough expectoration, sputum mixed with blood, expectoration is not well, uncomfortable in chest, chest pain, poor appetite, weak.Examine and see: light purplish tongue, tongue is white thick greasy, a little less than thready and hesitant pulse.Take after 2 courses for the treatment of of Chinese medicinal formulae of the embodiment of the present invention 1, symptom alleviates, continue to take 2 courses for the treatment of after CT examination focus number reduce, size of tumor diminishes, evident in efficacy.
Case 2: king so-and-so, man, 68 years old, gastric cancer, before 2 years, gastroscope is presented at lesser gastric curvature place and sees protrude type gastric cancer, pathological examination is tubular adenocarcinoma, after the large portion of stomach excision, recurs half a year, cannot again perform the operation, CT shows the multiple enlargement lymphs in abdominal cavity.Disease sees that diet reduces, loses weight, and vomiting after eating regurgitation, stool disturbance of defecation with either dry or loose stool, weak, stomachache.Examine and see: body of the tongue purple, tongue is greasy in vain, and there is indentation on limit, and at the bottom of tongue, vein purple is dim, and deficient and thready pulse is puckery.Take after 6 courses for the treatment of of the embodiment of the present invention 2 Chinese medicinal formulae, symptom alleviates, continue to take 2 courses for the treatment of after CT examination enlarged lymph node disappearance focus number reduce, diet improves, vomiting regurgitation transference cure, body weight increases by 8 kilograms, evident in efficacy.
Case 3: Lee so-and-so, female, 55, in year, breast carcinoma, recur after 3 years through protecting breast conserving surgery, B ultrasonic shows that right side mammary gland has multiple low echo agglomerates, person is 4c greatly
3m, little person is about 2cm
3, pathology is IDC, disease is seen distending pain of the breast, twinge, and distending pain in the chest and hypochondrium, irritated irritability, poor appetite is weak, becomes thin.Examine and see: purplish-red tongue, tongue is thick in vain, stringy and hesitant pulse.Patient refuses operative treatment again, the Chinese medicine of seeking medical advice.Take after 33 courses for the treatment of of Chinese medicinal formulae of the embodiment of the present invention, symptom alleviates, continue to take 3 courses for the treatment of after ultrasound diagnosis focus number reduce, size of tumor diminishes, evident in efficacy.
Claims (9)
1. a Chinese medicine composition for the treatment of malignant tumor, is characterized in that, is to be made up of the raw material of following weight parts:
Radix Trichosanthis 5-12 part, Rhizoma Sparganii 1-6 part, Rhizoma Curcumae 1-10 part, Semen Persicae 3-8 part, Flos Carthami 3-8 part, Semen Strychni (processed) 1-2 part, eupolyphaga 1-8 part, Scorpio 2-6 part, Scolopendra 1-3 part, Rhizoma Pinelliae 3-9 part, Rhizoma Arisaematis 1-10 part, Olibanum 3-5 part, Lignum Sappan 3-8 part, Radix Achyranthis Bidentatae 5-10 part, Fructus Crataegi 5-8 part, Radix Codonopsis 8-15 part, Radix Astragali 10-20 part.
2. a kind of Chinese medicine composition for the treatment of malignant tumor as claimed in claim 1, it is characterized in that, be to be made up of the raw material of following weight parts: 12 parts of Radix Trichosanthis, 6 parts of Rhizoma Sparganii, 10 parts of Rhizoma Curcumae, 6 parts, Semen Persicae, 6 parts, Flos Carthami, 1 part of Semen Strychni (processed), 8 parts of eupolyphaga, 6 parts of Scorpios, 2 parts of Scolopendras, 9 parts of the Rhizoma Pinelliaes, 10 parts of Rhizoma Arisaematiss, 3 parts of Olibanums, 8 parts of Lignum Sappans, 10 parts of Radix Achyranthis Bidentataes, 8 parts of Fructus Crataegis, 15 parts of Radix Codonopsis, 15 parts of the Radixs Astragali.
3. a kind of Chinese medicine composition for the treatment of malignant tumor as claimed in claim 1, it is characterized in that, be to be made up of the raw material of following weight parts: 8 parts of Radix Trichosanthis, 2 parts of Rhizoma Sparganii, 2 parts of Rhizoma Curcumae, 6 parts, Semen Persicae, 6 parts, Flos Carthami, 1 part of Semen Strychni (processed), 2 parts of eupolyphaga, 2 parts of Scorpios, 2 parts of Scolopendras, 3 parts of the Rhizoma Pinelliaes, 1 part of Rhizoma Arisaematis, 3 parts of Olibanums, 8 parts of Lignum Sappans, 8 parts of Radix Achyranthis Bidentataes, 6 parts of Fructus Crataegis, 10 parts of Radix Codonopsis, 15 parts of the Radixs Astragali.
4. the preparation method of the Chinese medicine composition of the treatment malignant tumor described in claims 1 to 3 any one, it is characterized in that, by raw material water merceration 30-60 minute, the w/v of raw material and water is 1g:3-5ml, is heated to boiling, decocts 30-60 minute, leach medicinal liquid, the water that to add with the w/v of medicinal residues in medicinal residues be 1g:2-4ml again, decocts 20-40 minute, merges twice decoction liquor.
5. a Chinese medicine preparation that is used for the treatment of malignant tumor, is characterized in that, is made up of Chinese medicine composition and adjuvant described in claims 1 to 3 any one.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that, it is capsule, tablet, granule or pill.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that, in fact capsule or tablet.
8. Chinese medicine preparation as claimed in claim 5, is characterized in that, described adjuvant is mannitol, lactose, starch, magnesium stearate, saccharin sodium, cellulose or magnesium carbonate.
9. the application of the Chinese medicine composition described in claims 1 to 3 any one in the medicine for the preparation for the treatment of spleen deficiency and blood stasis phlegm stagnation syndrome type malignant tumor.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920534A (en) * | 2016-06-16 | 2016-09-07 | 陕西中医药大学附属医院 | Traditional Chinese medicine composition for treating digestive tract malignant tumors and preparation of composition |
| CN108452240A (en) * | 2017-02-20 | 2018-08-28 | 上海中医药大学附属岳阳中西医结合医院 | A kind of antitumor Chinese medicine composition and its application |
| CN113599486A (en) * | 2021-09-01 | 2021-11-05 | 毕浪 | External medicine for treating tumor and preparation method thereof |
-
2014
- 2014-08-28 CN CN201410430909.0A patent/CN104147540A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920534A (en) * | 2016-06-16 | 2016-09-07 | 陕西中医药大学附属医院 | Traditional Chinese medicine composition for treating digestive tract malignant tumors and preparation of composition |
| CN108452240A (en) * | 2017-02-20 | 2018-08-28 | 上海中医药大学附属岳阳中西医结合医院 | A kind of antitumor Chinese medicine composition and its application |
| CN108452240B (en) * | 2017-02-20 | 2020-12-01 | 上海中医药大学附属岳阳中西医结合医院 | Anti-tumor traditional Chinese medicine composition and application thereof |
| CN113599486A (en) * | 2021-09-01 | 2021-11-05 | 毕浪 | External medicine for treating tumor and preparation method thereof |
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Application publication date: 20141119 |