CN104127844A - Preparation method for traditional Chinese medicine preparation used for treating senile constipation - Google Patents
Preparation method for traditional Chinese medicine preparation used for treating senile constipation Download PDFInfo
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Abstract
The invention relates to a preparation method for a traditional Chinese medicine preparation used for treating senile constipation. Radix Astragali, dwarf flowering cherry seed, Chinese angelica, black soya bean, cassia bark, magnolia cortex, licorice, dried ginger, bighead atractylodes rhizome, perilla seed, chrysanthemum, cistanche, bighead atractylodes rhizome and fortune eupatorium herb are used as traditional Chinese medicinal raw materials; priority is given to treatment, and treatment and recuperation are combined together; the prepared traditional Chinese medicine preparation has the advantages of reasonable composition, precise and concise compatibility, a definite therapeutic effect and capacity of simultaneous treatment of principal and subordinate symptoms of constipation. Since constipation is not treated at an early stage, constipation becomes habitual with the passing of time. According to the invention, Radix Astragali and bighead atractylodes rhizome which are sweet and mildly warm and can tonify Qi and invigorate the spleen are used as monarch drugs, dwarf flowering cherry seed, Chinese angelica, magnolia cortex, licorice, cistanche and perilla seed which are capable of rectifying qi, harmonizing the stomach and moistening the intestines are used as minister drugs, black soya bean, cassia bark, dried ginger, chrysanthemum, white peony root and fortune eupatorium herb are used as assistant and guide drugs, and combined usage of the traditional Chinese medicinal raw materials enables the Qi function to be smooth and transportation and transformation of the intestines and stomach to be normal, thereby allowing constipation to be automatically cured; and the traditional Chinese medicine preparation is especially applicable to treatment of senile constipation.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of preparation method of Chinese medicine preparation for the treatment of senile constipation.
Background technology
Constipation is that the kind of ingesting and custom, living habit, environmental factors, the mental status etc. can affect bowl evacuation habit because normal bowl evacuation habit is widely different.Old people is because body is aging, and digestive system can occur that physiological function goes down, so the incidence rate of constipation of old people is higher.Constipation belongs to not normal the causing of the large intestinal function conduction of human body, is common frdquently encountered disease, how because of gastrointestinal accumulated heat, body fluid being damaged causes intestinal to lead mistake profit, and large intestine is dry and hard, causes the reason of above-mentioned disease to be: mind is not relaxed, cause depression and stagnation of QI, BNO, in intestinal, the holdup time is long and constipated; Senile constipation is mainly because old, lies in bed for a long time motionless or quantity of motion is little, deficiency of qi and blood, cause large intestine Tianjin withered do not moisten dry and hard.Constipation meeting brings very major injury to human body, and continuous many days of some old men can not defecation, abdominal part feeling of distension and oppression, and face is withered and yellow, and difficult defecation is suffered untold misery.At present, in order to solve difficult defecation, adopt glycerin coloclysis or herbal enema, but all can not solving practical problems.Although the medicine of at present treatment constipation has certain curative effect, treat all not thorough, and have also have the obvious side effect such as diarrhoea.
Summary of the invention
The object of the invention is the deficiency for solving the problems of the technologies described above, a kind of preparation method of Chinese medicine preparation for the treatment of senile constipation is provided.
The present invention is the deficiency solving the problems of the technologies described above, and the technical scheme adopting is: a kind of preparation method of Chinese medicine preparation for the treatment of senile constipation, comprises the following steps:
(1) get 2～4 parts of 15～20 parts of astragalus roots, 10～15 parts of Semen Prunis, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts, Semen sojae atricolor, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Cortex Magnoliae Officinalis, 10～15 parts, Radix Glycyrrhizae, 10～15 parts of Rhizoma Zingiberiss, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 5～10 parts of Fructus Perillaes, 5～10 parts of Flos Chrysanthemis, 5～10 parts of Herba Cistanches, 5～10 parts of the Radix Paeoniae Albas, 10～15 parts of Herba Eupatoriis, 2～4 parts of maltodextrins and Mel according to parts by weight, for subsequent use;
(2) astragalus root is pulverized, in atmospheric pressure reflux extraction element, water heating and refluxing extraction 2 times, each reflux, extract, 2h, merge water extraction liquid, filter, supernatant directly adds 10% sodium hydroxide solution, leave standstill 3h, it is neutral regulating PH value with dilute hydrochloric acid, adsorb with macroporous adsorptive resins, with the deionized-distilled water eluting of 10 times of volumes, again with 40% ethanol eluting of 5 times of volumes, finally with 90% ethanol eluting, collect eluent for the third time, eluent is concentrated, centrifugal being precipitated, precipitation 20% ethyl alcohol recrystallization, obtain powder I,
(3) Semen sojae atricolor is cleaned to the rear aqueous solution soaking 12h with containing 0.15% sodium bicarbonate and 0.15% sodium chloride, then Semen sojae atricolor is pulled out and put into water heating and cooking, (addition of Fructus Amomi is 1% of water weight in water, to add Fructus Amomi and Folium Nelumbinis, the addition of Folium Nelumbinis be water weight 2%), heating and temperature control is at 95～98 DEG C, after decocting in water 50min, stop heating, pull out and dry, the ripe bean drying is put into halogen soup and carry out marinate, after first boiling with big fire, use little fiery boiling 30min instead, then stop heating, be allowed to condition in halogen soup and soak after 20h, pull out, drain thick gravy, then the Semen sojae atricolor that drains saltwater brine is dried and pulverized, obtain powder II,
(4) Radix Angelicae Sinensis is pulverized to rear 20 mesh sieves of crossing, utilize ultrasonic continuous countercurrent extractor to extract, aqueous extract is centrifugal with centrifuge, centrifugal liquid is at vacuum-0.06Mpa, under temperature 60 C condition, be concentrated into dry, obtain concentrate, 5 times of amount methanol stirring and dissolving at 50 DEG C for concentrate, filtration obtains methanol filtrate, to the petroleum ether that adds 0.5 times of volume in methanol filtrate, under room temperature, stir 30min, then leave standstill 60min, collect methanol layer, methanol layer carries out separation and purification by IV band simulated moving bed chromatography, chromatographic system operative temperature is 25 DEG C, the extract that collection contains ferulic acid, being concentrated into solid content is 40%, at 5 DEG C of standing 10h, collect crystallization, pulverize and obtain powder III,
(5) by Semen Pruni, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii, above-mentioned raw materials is broken into 100 object powder with disintegrating apparatus, and by various powder even blend, then pour in electric-heating container, the decocting that dosing grain weight amount is 10 times boils 8h, temperature is no more than 100 DEG C, filter medicinal residues, collect gained medicinal liquid, remaining tiny medicinal residues are removed in centrifugalize, then add powder I, powder II and powder III, after stirring, concentrate, 80 DEG C of thickening temperatures, time 40min, then add maltodextrin and Mel, fully stir, last spray drying forming, granulate, sieve, subpackage, sterilizing, quality inspection, be packaged to be Chinese medicine composition electuary.
The constituent of halogen soup is by weight in described step (3): 1000 parts, 355 parts of D-sorbitol solutions, 233 parts of white sugar, 0.38 part of nisin, 2 parts, Radix Glycyrrhizae, 2 parts of Fructus Arctiis, 1.2 parts, ascorbic acid, 1.45 parts of Folium Crataegi, 1.5 parts of Folium Hippophae, 15 parts of Yellow Mountain fuzz tip green tea and water.
When in described step (4), ultrasonic continuous countercurrent extractor extracts, ultrasonic power is 50W, and frequency is 50KHz, extracts temperature 60 C, and raw material pace is 5m/h, and water flow velocity is 20m/h.
When in described step (4), methanol layer carries out separation and purification by IV band simulated moving bed chromatography, mobile phase is (V/V) methanol: water=70: 30, sample introduction flow velocity is 0.1ml/ min, eluent flow rate is 2ml/min, and extract flow velocity is 2ml/min, and be 18min switching time.
The usage of electuary of the present invention: oral, each 1 to 2 bag, warm water takes after washing open, each 2 times 7 days is a course for the treatment of, be 2-4 visual effects the course for the treatment of conventionally.
beneficial effect
The present invention is directed to the feature of senile constipation, select the Radix Astragali, Semen Pruni, Radix Angelicae Sinensis, Semen sojae atricolor, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii as raw material of Chinese medicine, adopt to control as main, control the method for supporting combination, the medicament composing prescription of making is reasonable, compatibility is simplified, determined curative effect, can the treatment constipation for the treatment of both the principal and secondary aspects of a disease ground.Constipation, from the beginning of not controlling, with the passing of time forms the habit.Medicine of the present invention is monarch drug with the Radix Astragali and the Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening of sweet tepor, Semen Pruni, Radix Angelicae Sinensis, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Herba Cistanches and Fructus Perillae regulating qi-flowing for harmonizing stomach, intestine moistening are that ministerial drug, Semen sojae atricolor, Cortex Cinnamomi, Rhizoma Zingiberis, Flos Chrysanthemi, the Radix Paeoniae Alba and Herba Eupatorii are adjuvant, all medicines share, can make upper and lower mechanism of qi unobstructed, the intestines and stomach transporting is normal, constipation, from logical, is specially adapted to the treatment of senile constipation.
Medicine of the present invention is through clinical 121 routine patients' clinical verification, and curing number is 99 examples, and significant figure is 20 examples, and invalid number is 2 examples, and total effective rate reaches 98.3%.In therapeutic process, there are no toxic and side effects, obstinate patient is had to good curative effect.
Detailed description of the invention
embodiment 1
A preparation method for the treatment of the Chinese medicine preparation of senile constipation, comprises the following steps:
(1) get 2 parts of 15 parts of astragalus roots, 10 parts of Semen Prunis, 15 parts of Radix Angelicae Sinensis, 15 parts, Semen sojae atricolor, 10 parts of Cortex Cinnamomis, 10 parts of Cortex Magnoliae Officinalis, 10 parts, Radix Glycyrrhizae, 10 parts of Rhizoma Zingiberiss, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Fructus Perillaes, 5 parts of Flos Chrysanthemis, 5 parts of Herba Cistanches, 5 parts of the Radix Paeoniae Albas, 10 parts of Herba Eupatoriis, 2 parts of maltodextrins and Mel according to parts by weight, for subsequent use;
(2) astragalus root is pulverized, in atmospheric pressure reflux extraction element, water heating and refluxing extraction 2 times, each reflux, extract, 2h, merge water extraction liquid, filter, supernatant directly adds 10% sodium hydroxide solution, leave standstill 3h, it is neutral regulating PH value with dilute hydrochloric acid, adsorb with macroporous adsorptive resins, with the deionized-distilled water eluting of 10 times of volumes, again with 40% ethanol eluting of 5 times of volumes, finally with 90% ethanol eluting, collect eluent for the third time, eluent is concentrated, centrifugal being precipitated, precipitation 20% ethyl alcohol recrystallization, obtain powder I,
(3) Semen sojae atricolor is cleaned to the rear aqueous solution soaking 12h with containing 0.15% sodium bicarbonate and 0.15% sodium chloride, then Semen sojae atricolor is pulled out and put into water heating and cooking, (addition of Fructus Amomi is 1% of water weight in water, to add Fructus Amomi and Folium Nelumbinis, the addition of Folium Nelumbinis be water weight 2%), heating and temperature control is at 95 DEG C, after decocting in water 50min, stop heating, pull out and dry, the ripe bean drying is put into halogen soup and carry out marinate, after first boiling with big fire, use little fiery boiling 30min instead, then stop heating, be allowed to condition in halogen soup and soak after 20h, pull out, drain thick gravy, then the Semen sojae atricolor that drains saltwater brine is dried and pulverized, obtain powder II,
The constituent of halogen soup is by weight: 1000 parts, 355 parts of D-sorbitol solutions, 233 parts of white sugar, 0.38 part of nisin, 2 parts, Radix Glycyrrhizae, 2 parts of Fructus Arctiis, 1.2 parts, ascorbic acid, 1.45 parts of Folium Crataegi, 1.5 parts of Folium Hippophae, 15 parts of Yellow Mountain fuzz tip green tea and water.
(4) Radix Angelicae Sinensis is pulverized to rear 20 mesh sieves of crossing, utilize ultrasonic continuous countercurrent extractor to extract, aqueous extract is centrifugal with centrifuge, centrifugal liquid is at vacuum-0.06Mpa, under temperature 60 C condition, be concentrated into dry, obtain concentrate, 5 times of amount methanol stirring and dissolving at 50 DEG C for concentrate, filtration obtains methanol filtrate, to the petroleum ether that adds 0.5 times of volume in methanol filtrate, under room temperature, stir 30min, then leave standstill 60min, collect methanol layer, methanol layer carries out separation and purification by IV band simulated moving bed chromatography, chromatographic system operative temperature is 25 DEG C, the extract that collection contains ferulic acid, being concentrated into solid content is 40%, at 5 DEG C of standing 10h, collect crystallization, pulverize and obtain powder III,
When ultrasonic continuous countercurrent extractor extracts, ultrasonic power is 50W, and frequency is 50KHz, extracts temperature 60 C, and raw material pace is 5m/h, and water flow velocity is 20m/h.
When methanol layer carries out separation and purification by IV band simulated moving bed chromatography, mobile phase is (V/V) methanol: water=70: 30, and sample introduction flow velocity is 0.1ml/min, and eluent flow rate is 2ml/min, and extract flow velocity is 2ml/min, and be 18min switching time.
(5) by Semen Pruni, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii, above-mentioned raw materials is broken into 100 object powder with disintegrating apparatus, and by various powder even blend, then pour in electric-heating container, the decocting that dosing grain weight amount is 10 times boils 8h, temperature is no more than 100 DEG C, filter medicinal residues, collect gained medicinal liquid, remaining tiny medicinal residues are removed in centrifugalize, then add powder I, powder II and powder III, after stirring, concentrate, 80 DEG C of thickening temperatures, time 40min, then add maltodextrin and Mel, fully stir, last spray drying forming, granulate, sieve, subpackage, sterilizing, quality inspection, be packaged to be Chinese medicine composition electuary.
The active component ferulic acid ferulic acid of Radix Angelicae Sinensis extract has good intestinal absorption facilitation to astragaloside, and after astragaloside enters in human body, can bring into play cooperative effect, promotes astragaloside in intestinal absorption effect.
embodiment 2
A preparation method for the treatment of the Chinese medicine preparation of senile constipation, comprises the following steps:
(1) get 4 parts of 20 parts of astragalus roots, 15 parts of Semen Prunis, 20 parts of Radix Angelicae Sinensis, 20 parts, Semen sojae atricolor, 15 parts of Cortex Cinnamomis, 15 parts of Cortex Magnoliae Officinalis, 15 parts, Radix Glycyrrhizae, 15 parts of Rhizoma Zingiberiss, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Fructus Perillaes, 10 parts of Flos Chrysanthemis, 10 parts of Herba Cistanches, 10 parts of the Radix Paeoniae Albas, 15 parts of Herba Eupatoriis, 4 parts of maltodextrins and Mel according to parts by weight, for subsequent use;
(2) astragalus root is pulverized, in atmospheric pressure reflux extraction element, water heating and refluxing extraction 2 times, each reflux, extract, 2h, merge water extraction liquid, filter, supernatant directly adds 10% sodium hydroxide solution, leave standstill 3h, it is neutral regulating PH value with dilute hydrochloric acid, adsorb with macroporous adsorptive resins, with the deionized-distilled water eluting of 10 times of volumes, again with 40% ethanol eluting of 5 times of volumes, finally with 90% ethanol eluting, collect eluent for the third time, eluent is concentrated, centrifugal being precipitated, precipitation 20% ethyl alcohol recrystallization, obtain powder I,
(3) Semen sojae atricolor is cleaned to the rear aqueous solution soaking 12h with containing 0.15% sodium bicarbonate and 0.15% sodium chloride, then Semen sojae atricolor is pulled out and put into water heating and cooking, (addition of Fructus Amomi is 1% of water weight in water, to add Fructus Amomi and Folium Nelumbinis, the addition of Folium Nelumbinis be water weight 2%), heating and temperature control is at 95 DEG C, after decocting in water 50min, stop heating, pull out and dry, the ripe bean drying is put into halogen soup and carry out marinate, after first boiling with big fire, use little fiery boiling 30min instead, then stop heating, be allowed to condition in halogen soup and soak after 20h, pull out, drain thick gravy, then the Semen sojae atricolor that drains saltwater brine is dried and pulverized, obtain powder II,
The constituent of halogen soup is by weight: 1000 parts, 355 parts of D-sorbitol solutions, 233 parts of white sugar, 0.38 part of nisin, 2 parts, Radix Glycyrrhizae, 2 parts of Fructus Arctiis, 1.2 parts, ascorbic acid, 1.45 parts of Folium Crataegi, 1.5 parts of Folium Hippophae, 15 parts of Yellow Mountain fuzz tip green tea and water.
(4) Radix Angelicae Sinensis is pulverized to rear 20 mesh sieves of crossing, utilize ultrasonic continuous countercurrent extractor to extract, aqueous extract is centrifugal with centrifuge, centrifugal liquid is at vacuum-0.06Mpa, under temperature 60 C condition, be concentrated into dry, obtain concentrate, 5 times of amount methanol stirring and dissolving at 50 DEG C for concentrate, filtration obtains methanol filtrate, to the petroleum ether that adds 0.5 times of volume in methanol filtrate, under room temperature, stir 30min, then leave standstill 60min, collect methanol layer, methanol layer carries out separation and purification by IV band simulated moving bed chromatography, chromatographic system operative temperature is 25 DEG C, the extract that collection contains ferulic acid, being concentrated into solid content is 40%, at 5 DEG C of standing 10h, collect crystallization, pulverize and obtain powder III,
When ultrasonic continuous countercurrent extractor extracts, ultrasonic power is 50W, and frequency is 50KHz, extracts temperature 60 C, and raw material pace is 5m/h, and water flow velocity is 20m/h.
When methanol layer carries out separation and purification by IV band simulated moving bed chromatography, mobile phase is (V/V) methanol: water=70: 30, and sample introduction flow velocity is 0.1ml/min, and eluent flow rate is 2ml/min, and extract flow velocity is 2ml/min, and be 18min switching time.
(5) by Semen Pruni, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii, above-mentioned raw materials is broken into 100 object powder with disintegrating apparatus, and by various powder even blend, then pour in electric-heating container, the decocting that dosing grain weight amount is 10 times boils 8h, temperature is no more than 100 DEG C, filter medicinal residues, collect gained medicinal liquid, remaining tiny medicinal residues are removed in centrifugalize, then add powder I, powder II and powder III, after stirring, concentrate, 80 DEG C of thickening temperatures, time 40min, then add maltodextrin and Mel, fully stir, last spray drying forming, granulate, sieve, subpackage, sterilizing, quality inspection, be packaged to be Chinese medicine composition electuary.
embodiment 3
A preparation method for the treatment of the Chinese medicine preparation of senile constipation, comprises the following steps:
(1) get 3 parts of 18 parts of astragalus roots, 14 parts of Semen Prunis, 18 parts of Radix Angelicae Sinensis, 18 parts, Semen sojae atricolor, 14 parts of Cortex Cinnamomis, 14 parts of Cortex Magnoliae Officinalis, 12 parts, Radix Glycyrrhizae, 12 parts of Rhizoma Zingiberiss, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Fructus Perillaes, 8 parts of Flos Chrysanthemis, 7 parts of Herba Cistanches, 7 parts of the Radix Paeoniae Albas, 12 parts of Herba Eupatoriis, 3 parts of maltodextrins and Mel according to parts by weight, for subsequent use;
(2) astragalus root is pulverized, in atmospheric pressure reflux extraction element, water heating and refluxing extraction 2 times, each reflux, extract, 2h, merge water extraction liquid, filter, supernatant directly adds 10% sodium hydroxide solution, leave standstill 3h, it is neutral regulating PH value with dilute hydrochloric acid, adsorb with macroporous adsorptive resins, with the deionized-distilled water eluting of 10 times of volumes, again with 40% ethanol eluting of 5 times of volumes, finally with 90% ethanol eluting, collect eluent for the third time, eluent is concentrated, centrifugal being precipitated, precipitation 20% ethyl alcohol recrystallization, obtain powder I,
(3) Semen sojae atricolor is cleaned to the rear aqueous solution soaking 12h with containing 0.15% sodium bicarbonate and 0.15% sodium chloride, then Semen sojae atricolor is pulled out and put into water heating and cooking, (addition of Fructus Amomi is 1% of water weight in water, to add Fructus Amomi and Folium Nelumbinis, the addition of Folium Nelumbinis be water weight 2%), heating and temperature control is at 95 DEG C, after decocting in water 50min, stop heating, pull out and dry, the ripe bean drying is put into halogen soup and carry out marinate, after first boiling with big fire, use little fiery boiling 30min instead, then stop heating, be allowed to condition in halogen soup and soak after 20h, pull out, drain thick gravy, then the Semen sojae atricolor that drains saltwater brine is dried and pulverized, obtain powder II,
The constituent of halogen soup is by weight: 1000 parts, 355 parts of D-sorbitol solutions, 233 parts of white sugar, 0.38 part of nisin, 2 parts, Radix Glycyrrhizae, 2 parts of Fructus Arctiis, 1.2 parts, ascorbic acid, 1.45 parts of Folium Crataegi, 1.5 parts of Folium Hippophae, 15 parts of Yellow Mountain fuzz tip green tea and water.
(4) Radix Angelicae Sinensis is pulverized to rear 20 mesh sieves of crossing, utilize ultrasonic continuous countercurrent extractor to extract, aqueous extract is centrifugal with centrifuge, centrifugal liquid is at vacuum-0.06Mpa, under temperature 60 C condition, be concentrated into dry, obtain concentrate, 5 times of amount methanol stirring and dissolving at 50 DEG C for concentrate, filtration obtains methanol filtrate, to the petroleum ether that adds 0.5 times of volume in methanol filtrate, under room temperature, stir 30min, then leave standstill 60min, collect methanol layer, methanol layer carries out separation and purification by IV band simulated moving bed chromatography, chromatographic system operative temperature is 25 DEG C, the extract that collection contains ferulic acid, being concentrated into solid content is 40%, at 5 DEG C of standing 10h, collect crystallization, pulverize and obtain powder III,
When ultrasonic continuous countercurrent extractor extracts, ultrasonic power is 50W, and frequency is 50KHz, extracts temperature 60 C, and raw material pace is 5m/h, and water flow velocity is 20m/h.
When methanol layer carries out separation and purification by IV band simulated moving bed chromatography, mobile phase is (V/V) methanol: water=70: 30, and sample introduction flow velocity is 0.1ml/min, and eluent flow rate is 2ml/min, and extract flow velocity is 2ml/min, and be 18min switching time.
(5) by Semen Pruni, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii, above-mentioned raw materials is broken into 100 object powder with disintegrating apparatus, and by various powder even blend, then pour in electric-heating container, the decocting that dosing grain weight amount is 10 times boils 8h, temperature is no more than 100 DEG C, filter medicinal residues, collect gained medicinal liquid, remaining tiny medicinal residues are removed in centrifugalize, then add powder I, powder II and powder III, after stirring, concentrate, 80 DEG C of thickening temperatures, time 40min, then add maltodextrin and Mel, fully stir, last spray drying forming, granulate, sieve, subpackage, sterilizing, quality inspection, be packaged to be Chinese medicine composition electuary.
model case
Case 1: Zhang, female, 71 years old, be hard and dry for a long time, sometimes 6-7 days once, plucks out, and have blood in stool when stool with hands, agonizing, repeatedly treatment is still ineffective, takes two, the Chinese medicine of the present invention symptom course for the treatment of and takes a favourable turn, and ambassador's normal two or three days once, continue to take and defecate two courses for the treatment of normally, once a day.Be interrupted after treatment, more than a year without recurrence.
Case 2: Chen, female, 68 years old, since 2010, be hard and dry for a long time, sometimes within more than ten day, solution is once defecated, pain that abdominal part is swollen, and complexion is withered and yellow gloomy, once the charthartic such as long-time taking senna, intestinal green tea, but all not from substantially dealing with problems, start to take Chinese medicine of the present invention one month in June, 2010, stool starts normal, after consolidate again a course for the treatment of, without recurrence.
Case 3: Liao, female, 82 years old, in JIUYUE, 2012 was medical.Patient's readme dyschesia, discharges effort more than approximately 6 years, and every 7-8 day defecate once, and dry stool is difficult for discharging, and start to take Chinese medicine of the present invention one month in October, 2012, and stool starts normal, after consolidate again a course for the treatment of, without recurring.
Case 4: journey female 68 years old, constipation in 10 years, due to prolapse of lumbar intervertebral disc, handicapped, frequent constipation in nearly a year, take the just alleviation of TONGBIAN LING, externally used piles bolt, can not cure, start to take Chinese medicine of the present invention two months in February, 2013, and stool starts normal, after consolidate again a course for the treatment of, without recurrence.
Claims (4)
1. a preparation method for the treatment of the Chinese medicine preparation of senile constipation, is characterized in that: comprise the following steps:
(1) get 2～4 parts of 15～20 parts of astragalus roots, 10～15 parts of Semen Prunis, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts, Semen sojae atricolor, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Cortex Magnoliae Officinalis, 10～15 parts, Radix Glycyrrhizae, 10～15 parts of Rhizoma Zingiberiss, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 5～10 parts of Fructus Perillaes, 5～10 parts of Flos Chrysanthemis, 5～10 parts of Herba Cistanches, 5～10 parts of the Radix Paeoniae Albas, 10～15 parts of Herba Eupatoriis, 2～4 parts of maltodextrins and Mel according to parts by weight, for subsequent use;
(2) astragalus root is pulverized, in atmospheric pressure reflux extraction element, water heating and refluxing extraction 2 times, each reflux, extract, 2h, merge water extraction liquid, filter, supernatant directly adds 10% sodium hydroxide solution, leave standstill 3h, regulating pH value with dilute hydrochloric acid is neutrality, adsorbs with macroporous adsorptive resins, with the deionized-distilled water eluting of 10 times of volumes, again with 40% ethanol eluting of 5 times of volumes, finally, with 90% ethanol eluting, collect eluent for the third time, eluent is concentrated, centrifugal being precipitated, precipitation is used 20% ethyl alcohol recrystallization, obtains powder I;
(3) Semen sojae atricolor is cleaned to the rear aqueous solution soaking 12h with containing 0.15% sodium bicarbonate and 0.15% sodium chloride, then Semen sojae atricolor is pulled out and put into water heating and cooking, in water, add Fructus Amomi and Folium Nelumbinis, heating and temperature control is at 95～98 DEG C, after decocting in water 50min, stop heating, pull out and dry, the ripe bean drying is put into halogen soup and carry out marinate, after first boiling with big fire, use little fiery boiling 30min instead, then stop heating, be allowed to condition in halogen soup and soak after 20h, pull out, drain thick gravy, then the Semen sojae atricolor that drains saltwater brine is dried and pulverized, obtain powder II;
(4) Radix Angelicae Sinensis is pulverized to rear 20 mesh sieves of crossing, utilize ultrasonic continuous countercurrent extractor to extract, aqueous extract is centrifugal with centrifuge, centrifugal liquid is at vacuum-0.06Mpa, under temperature 60 C condition, be concentrated into dry, obtain concentrate, 5 times of amount methanol stirring and dissolving at 50 DEG C for concentrate, filtration obtains methanol filtrate, to the petroleum ether that adds 0.5 times of volume in methanol filtrate, under room temperature, stir 30min, then leave standstill 60min, collect methanol layer, methanol layer carries out separation and purification by IV band simulated moving bed chromatography, chromatographic system operative temperature is 25 DEG C, the extract that collection contains ferulic acid, being concentrated into solid content is 40%, at 5 DEG C of standing 10h, collect crystallization, pulverize and obtain powder III,
(5) by Semen Pruni, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae, Fructus Perillae, Flos Chrysanthemi, Herba Cistanches, the Radix Paeoniae Alba and Herba Eupatorii, above-mentioned raw materials is broken into 100 object powder with disintegrating apparatus, and by various powder even blend, then pour in electric-heating container, the decocting that dosing grain weight amount is 10 times boils 8h, temperature is no more than 100 DEG C, filter medicinal residues, collect gained medicinal liquid, remaining tiny medicinal residues are removed in centrifugalize, then add powder I, powder II and powder III, after stirring, concentrate, 80 DEG C of thickening temperatures, time 40min, then add maltodextrin and Mel, fully stir, last spray drying forming, granulate, sieve, subpackage, sterilizing, quality inspection, be packaged to be Chinese medicine composition electuary.
2. the preparation method of a kind of Chinese medicine preparation for the treatment of senile constipation as claimed in claim 1, is characterized in that: the constituent of halogen soup is by weight in described step (3): 1000 parts, 355 parts of D-sorbitol solutions, 233 parts of white sugar, 0.38 part of nisin, 2 parts, Radix Glycyrrhizae, 2 parts of Fructus Arctiis, 1.2 parts, ascorbic acid, 1.45 parts of Folium Crataegi, 1.5 parts of Folium Hippophae, 15 parts of Yellow Mountain fuzz tip green tea and water.
3. the preparation method of a kind of Chinese medicine preparation for the treatment of senile constipation as claimed in claim 1, it is characterized in that: when in described step (4), ultrasonic continuous countercurrent extractor extracts, ultrasonic power is 50W, frequency is 50KHz, extract temperature 60 C, raw material pace is 5m/h, and water flow velocity is 20m/h.
4. the preparation method of a kind of Chinese medicine preparation for the treatment of senile constipation as claimed in claim 1, it is characterized in that: when in described step (4), methanol layer IV band simulated moving bed chromatography is carried out separation and purification, mobile phase is (V/V) methanol: water=70: 30, sample introduction flow velocity is 0.1ml/ min, eluent flow rate is 2ml/min, extract flow velocity is 2ml/min, and be 18min switching time.
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