CN104042548B - A kind of snail mucus extract and preparation method thereof and the application in cosmetics - Google Patents
A kind of snail mucus extract and preparation method thereof and the application in cosmetics Download PDFInfo
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Abstract
The invention discloses a kind of snail mucus extract, wherein containing chondroitin sulfate 0.1~5%, allantoin 0.1~5%, collagen 0.1~10%, the molecular weight distribution of micromolecule polypeptide is in 3000~5500 dalton.Preparation method the invention also discloses snail mucus extract and the application in cosmetics.It is an advantage of the invention that：Employ high-pressure homogenization extraction and multistage UF membrane joint technology, snail mucus active ingredient is highly enriched, snail mucus extract contains chondroitin sulfate 0.1~5%, allantoin 0.1~5%, the molecular weight distribution of collagen 0.1~10%, particularly micromolecule polypeptide is in 3000~5500 dalton, it is very suitable for human skin absorption, addition is conducive to repair impaired skin in cosmetics, promotes healing, accelerates cytothesis.
Description
Technical field
The present invention relates to a kind of snail mucus extract and its application, more particularly to a kind of snail mucus extract and its system
Preparation Method and the application in cosmetics.
Background technology
Cepaea Gastropoda terrestrial mollush has very high edible and medical value.The kind that China generally cultivates
There is white jade snail, collagen, allantoin, chondroitin sulfate, vitamin, natural antibacterial peptide isoreactivity are mainly contained in mucus
Ingredient.Wherein allantoin can make skin regeneration；Protein and vitamin can increase the nutrition of skin, make skin finer and smoother
With it is smooth.
At present, foods and cosmetics field is concentrated on to the application and development majority of snail product, it is studied mainly more
Sugar, glusulase, secretion extraction in terms of, but there are no cosmetics-stage snail mucus extract research report.
《Tropical disease and parasitology》" the bradybaena kiangsiensis active constituent extraction side that the 3rd phase of volume 3 in 2005 publishes
The comparative studies of method " reports a day snail polysaccharide extracting method.《Chinese biochemical drug magazine》What the 2nd phase in 1993 published
" research and application of glusulase " reports the method from snail glandula digestive extraction glusulase.Application No. is
The Chinese invention patent application of CN201210292779.X discloses a kind of extracting method of snail mucus, using moment electric shock snail
Ox foot collects the mucus of snail pedal gland secretion, then obtains snail secretion by freeze-drying.
Study snail report majority at present and concentrate on the extractions of polysaccharide, glusulase, snail mucus etc., have no containing
The preparation process of the cosmetics-stage snail mucus extract of the ingredients such as collagen, allantoin, chondroitin sulfate, micromolecule polypeptide
The research report of aspect, carries out in terms of also there are no the effect of snail mucus extract is in cosmetic applications effect and safety
The research of evaluation.In view of snail mucus extract can be more and more extensive in the application in cosmetics, it is necessary to just for used for cosmetic
The active constituent of snail mucus extract, safety studied, to ensure work(that Limax extract is applied in cosmetics
Effect and safety.
Invention content
The shortcomings that it is an object of the invention to overcome the prior art and deficiency, provide a kind of apply and are conducive in cosmetics
Impaired skin is repaired, promotes healing, accelerates the snail mucus extract of cytothesis.
Another object of the present invention is to provide a kind of preparation method of snail mucus extract.
Third purpose of the present invention is to provide a kind of application of snail mucus extract in cosmetics.
To achieve these goals, the present invention is achieved through the following technical solutions：A kind of snail mucus extract, wherein containing
There are chondroitin sulfate 0.1~5%, allantoin 0.1~5%, collagen 0.1~10%, the molecular weight distribution of micromolecule polypeptide
In 3000~5500 dalton, it is very suitable for human skin absorption, adds and be conducive to repair impaired skin in cosmetics, promote
Into healing, accelerate cytothesis.
The snail mucus extract is made from extraction, to mainly contain collagen, allantois from white jade snail mucus
Element, chondroitin sulfate, micromolecule polypeptide active constituent.
The snail mucus extract is through the following steps that obtained：Snail mucus is taken to be uniformly mixed with deionized water
Afterwards, it is extracted in high pressure homogenizer；Material is extracted after centrifuge detaches, obtains limpid extracting solution；Extracting solution is handled through micro-filtration,
Except degerm, bacteria-removing liquid is made in the impurity such as microorganism；Bacteria-removing liquid ultra-filtration and separation removes the human bodies such as albumen, the polysaccharide of macromolecular
Skin is difficult to the substance absorbed；Then it is concentrated again with nanofiltration, obtains the snail mucus extract used for cosmetics.
A kind of preparation method of snail mucus extract, includes the following steps：
(1) it extracts：Snail mucus is taken, adds in the water of 5~30 times of its quality, is pressed in 5~60 DEG C of temperature and 40~100Mpa
High-pressure homogenization historrhexis is carried out under power to extract 1~3 time.
(2) it centrifuges：High-pressure homogenization material obtained by (1) step with centrifuge is detached, collects clear liquid.
(3) micro-filtration：Clear liquid aperture is 0.1 μm -0.5 μm of microfiltration of ceramic membrane, except degerm, the impurity such as microorganism；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 6,000~50,000 dalton, is removed
The human skins such as albumen, the polysaccharide of macromolecular are difficult to the substance absorbed；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 80~2,000 dalton of molecular cut off, collects concentrate,
Snail mucus extract is obtained, the snail mucus extract used for cosmetics is concentrated to give by nanofiltration.
The mucus that the preferred white jade snail of snail mucus generates.
A kind of application of snail mucus extract in cosmetics, additive amount are 0.5-20%.
A kind of anti-apolexis composition, including following parts by weight component：
A kind of anti-ageing face mask, including following parts by weight component：
The allantoin that snail mucus extract contains can repair impaired skin, promote healing, accelerate cytothesis；Collagen egg
It is white that there is the effect of keeping moisture, enhancing skin elasticity；Chondroitin sulfate is conducive to remove old cutin, reduce wrinkle of skin and
Scar；Boy's polypeptide has the function of that skin is stimulated to regenerate, lighten the stain, promoting skin quality and glossiness.
Compared with prior art, it is an advantage of the invention that：High-pressure homogenization extraction and multistage UF membrane joint technology are employed,
Snail mucus active ingredient is highly enriched, and snail mucus extract contains chondroitin sulfate 0.1~5%, allantoin 0.1~5%,
The molecular weight distribution of collagen 0.1~10%, particularly micromolecule polypeptide is very suitable for people in 3000~5500 dalton
Body skin absorbs, and adds and is conducive to repair impaired skin in cosmetics, promote healing, accelerates cytothesis.
Description of the drawings
Fig. 1 is inventive technique process flow chart：Illustrate the main technical procedures of the present invention, wherein high-pressure homogenization extraction knot
Close the key problem in technology that multistage membrane separation concentration is the present invention；
Fig. 2 is product molecular weight distribution figure：Represent the molecular weight point for polypeptide in snail mucus extract used for cosmetic
Cloth situation is mainly distributed on 3000~5500 dalton；
Fig. 3 is product cell proliferation experimental result picture：Expression is added to for snail mucus extract cell used for cosmetic
Proliferation experiment result；
Fig. 4 is product blank group cell proliferation experimental result picture：Represent the cell repair experimental result of blank group.
Specific embodiment
With reference to embodiment and attached drawing, the present invention is described in further detail, but embodiments of the present invention are unlimited
In this.
Embodiment 1
A kind of snail mucus extract, wherein containing chondroitin sulfate 0.2% (mass percentage content), allantoin
0.2%, collagen 0.2%, the molecular weight distribution of micromolecule polypeptide is in 3100 dalton.
Embodiment 2
A kind of snail mucus extract, wherein containing chondroitin sulfate 4.9%, allantoin 4.9%, collagen 9.9%,
The molecular weight distribution of micromolecule polypeptide is in 5400 dalton.
Embodiment 3
A kind of snail mucus extract, wherein containing chondroitin sulfate 1~3%, allantoin 1~3%, collagen 1~
6%, the molecular weight distribution of micromolecule polypeptide is in 3500~5000 dalton.
Embodiment 4
A kind of snail mucus extract, wherein containing chondroitin sulfate 2.5%, allantoin 2.5%, collagen 5% is small
The molecular weight distribution of molecular polypeptide is very suitable for human skin absorption, adds and be conducive in cosmetics in 4500 dalton
Impaired skin is repaired, promotes healing, accelerates cytothesis.
Embodiment 5
The preparation method of above-mentioned snail mucus extract, as shown in Figure 1, it includes the following steps：
(1) it extracts：Snail mucus is taken, adds in the water of 6 times of its quality, high-pressure homogenization is used at 8 DEG C of temperature and 50Mpa pressure
Device carries out high-pressure homogenization historrhexis and extracts 1~3 time.
(2) it centrifuges：High-pressure homogenization material obtained by (1) step with centrifuge is detached, collects clear liquid；Centrifuge speed can
Think 500-1300 revs/min；
(3) micro-filtration：Microfiltration of ceramic membrane of the clear liquid aperture for 0.2 μm of m, except degerm, the impurity such as microorganism；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 6,500 dalton, removes macromolecular
The human skins such as albumen, polysaccharide are difficult to the substance absorbed；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 100 dalton of molecular cut off, collects concentrate, obtains snail
Ox mucus extract is concentrated to give the snail mucus extract used for cosmetics by nanofiltration.
Embodiment 6
The preparation method of above-mentioned snail mucus extract, includes the following steps：
(1) it extracts：Snail mucus is taken, adds in the water of 29 times of its quality, it is even with high pressure at 59 DEG C of temperature and 99Mpa pressure
It starches device and carries out high-pressure homogenization historrhexis extraction 1~3 time.
(2) it centrifuges：High-pressure homogenization material obtained by (1) step with centrifuge is detached, collects clear liquid.
(3) micro-filtration：Clear liquid aperture is 0.49 μm of microfiltration of ceramic membrane, except degerm, the impurity such as microorganism；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 49,000 dalton, removes macromolecular
The human skins such as albumen, polysaccharide are difficult to the substance absorbed；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 1900 dalton of molecular cut off, collects concentrate, obtains
Snail mucus extract is concentrated to give the snail mucus extract used for cosmetics by nanofiltration.
Embodiment 7
The preparation method of above-mentioned snail mucus extract, includes the following steps：
(1) it extracts：Snail mucus is taken, adds in the water of 20 times of its quality, it is even with high pressure at 45 DEG C of temperature and 75Mpa pressure
It starches device and carries out high-pressure homogenization historrhexis extraction 2 times.
(2) it centrifuges：High-pressure homogenization material obtained by (1) step with centrifuge is detached, collects clear liquid.
(3) micro-filtration：Clear liquid aperture is 0.3 μm of microfiltration of ceramic membrane, except degerm, the impurity such as microorganism；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 35,000 dalton, removes macromolecular
The human skins such as albumen, polysaccharide are difficult to the substance absorbed；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 1800 dalton of molecular cut off, collects concentrate, obtains
Snail mucus extract is concentrated to give the snail mucus extract used for cosmetics by nanofiltration.
The extraction and isolation technics that the present invention uses, entire production process can carry out under cryogenic, ensure that collagen
Albumen, micromolecule polypeptide isoreactivity ingredient are not destroyed.Simultaneously because employing multistage membrane separation technique, snail mucus is eliminated
Macromolecular substances and bacterial micro-organism, highly enriched collagen and micromolecule polypeptide ensure that snail mucus extract is being made up
It the safety of product application and acts in terms of skin repair the effect of.
Wherein, the mucus that the preferred white jade snail of the snail mucus generates.The preferred hollow-fibre membrane of ultrafiltration membrane, it is described
Ultrafiltration membrane of the hollow-fibre membrane internal diameter between 0.6-6mm is known as capillary type ultrafiltration membrane, capillary type ultrafiltration membrane because internal diameter compared with
Greatly, it is not easy to be blocked by large particulate matter.The NF membrane can be made of polyamide material.
Embodiment 8
1.0kg snail mucus is taken, is placed in extraction kettle, is added in the water of 30.0L, be heated to 60 DEG C, after being uniformly mixed,
It is extracted 3 times in high pressure homogenizer.Obtained extraction material is detached with centrifuge, removes deposit.Centrifugate is used
Aperture is handled for 0.5 μm of microfiltration of ceramic membrane, the ultrafiltration membrane ultrafiltration of 50,000 dalton of molecular cut off of micro-filtration dialyzate, ultrafiltration
Dialyzate is concentrated with 2,000 dalton NF membrane of molecular cut off, is collected concentrate, is obtained snail mucus extract product
118g, yield 11.8%.
Embodiment 9
4.5kg snail mucus is taken, is placed in extraction kettle, is added in the water of 22.5L, be cooled to 5 DEG C, after being uniformly mixed,
It is extracted 1 time in high pressure homogenizer.Obtained extraction material is detached with centrifuge, removes deposit.Centrifugate is used
Aperture is handled for 0.1 μm of microfiltration of ceramic membrane, the ultrafiltration membrane ultrafiltration of 6,000 dalton of molecular cut off of micro-filtration dialyzate, ultrafiltration
Dialyzate is concentrated with 80 dalton NF membrane of molecular cut off, is collected concentrate, is obtained snail mucus extract product 841g, is received
Rate 18.7%.
Embodiment 10
2.2kg snail mucus is taken, is placed in extraction kettle, is added in the water of 33.0L, be heated to 40 DEG C, after being uniformly mixed,
It is extracted 2 times in high pressure homogenizer.Obtained extraction material is detached with centrifuge, removes deposit.Centrifugate is used
Aperture is handled for 0.3 μm of microfiltration of ceramic membrane, the ultrafiltration membrane ultrafiltration of 10,000 dalton of molecular cut off of micro-filtration dialyzate, ultrafiltration
Dialyzate is concentrated with 500 dalton NF membrane of molecular cut off, is collected concentrate, is obtained snail mucus extract product 702g,
Yield 31.9%.
Embodiment 11
3.5kg snail mucus is taken, is placed in extraction kettle, adds in the water of 28.0L, is stirred under the conditions of 25 DEG C of room temperature
After even, extracted 3 times in high pressure homogenizer.Obtained extraction material is detached with centrifuge, removes deposit.Centrifugation
Liquid aperture is handled for 0.2 μm of microfiltration of ceramic membrane, the ultrafiltration membrane ultrafiltration of micro-filtration dialyzate 6,000 dalton of molecular cut off,
Ultrafiltration dialysis liquid is concentrated with 1,000 dalton NF membrane of molecular cut off, is collected concentrate, is obtained snail mucus extract product
2.1kg, yield 60.0%.
Embodiment 12
3.0kg snail mucus is taken, is placed in extraction kettle, adds in the water of 30.0L, is stirred under the conditions of 25 DEG C of room temperature
After even, extracted 2 times in high pressure homogenizer.Obtained extraction material is detached with centrifuge, removes deposit.Centrifugation
Liquid aperture is handled for 0.3 μm of microfiltration of ceramic membrane, the ultrafiltration membrane ultrafiltration of micro-filtration dialyzate 8,000 dalton of molecular cut off,
Ultrafiltration dialysis liquid is concentrated with 800 dalton NF membrane of molecular cut off, is collected concentrate, is obtained snail mucus extract product
1.6kg, yield 53.3%.
Chondroitin sulfate, allantoin, the collagen content of snail mucus extract obtained by above-described embodiment, Yi Ji little
The molecular weight distribution result of sub- peptide, which summarizes, see the table below：
According to《Cosmetics management and safety and Efficiency assessment》Regulation, carried out the skin of snail mucus extract
Detection in terms of irritant test, Ocular irritation experiment and bacterial micro-organism, indices result meet the requirement of cosmetics.
Snail mucus extract of the present invention can effectively improve Skin Cell differentiation of self and replication capacity, and former albumen, which has, to be protected
The effect of water holding point, enhancing skin elasticity；Chondroitin sulfate is conducive to remove old cutin, reduces wrinkle of skin and scar；It is small
Sub- polypeptide has the function of that skin is stimulated to regenerate, lighten the stain, promoting skin quality and glossiness.Specific detection is referring to Fig. 2-4
It is shown,.
A kind of application of snail mucus extract in the cosmetics such as cream, aqua, lotion, preferred additive amount are
1-10%.Most preferably, the additive amount of snail mucus extract is 5%.
Embodiment 13
A kind of anti-apolexis composition, including following parts by weight component：
Embodiment 14
A kind of anti-apolexis composition, including following parts by weight component：
Embodiment 15
A kind of anti-apolexis composition, including following parts by weight component：
A kind of preparation method of above-mentioned anti-apolexis composition is as follows：
(1) first disodium ethylene diamine tetraacetate is added in water phase and stirred, while kept the temperature after being heated to 80-90 degrees Celsius
Half an hour；
(2) polyglycereol, hydrogenated starch hydrolysate, carragheen and Sodium Hyaluronate are sequentially added in (1) step water phase, is stirred
It mixes and starts to cool down to after being completely dissolved；
(3) aloe extract, trehalose, vitamin E and dextran, stirring are added in after temperature drops to 45-55 degrees Celsius
Uniformly；
(4) snail mucus extract is added in after cooling the temperature to 35-45 degrees Celsius and is stirred evenly；
(5) it is 7-8 to be eventually adding and regulate pH value with sodium hydroxide, is stirred evenly.
Embodiment 16
A kind of anti-ageing face mask, including following parts by weight component：
Embodiment 17
A kind of anti-ageing face mask, including following parts by weight component：
Embodiment 18
A kind of anti-ageing face mask, including following parts by weight component：
A kind of preparation method of above-mentioned anti-ageing face mask is as follows：
(1) disodium ethylene diamine tetraacetate (EDTA-2Na) is added in water to stir, while be heated to 80-90 degrees Celsius
After keep the temperature half an hour；
(2) polyglycereol, hydrogenated starch hydrolysate, carragheen and Sodium Hyaluronate are sequentially added, with the rotating speed of 20-50rpm
Stirring starts to cool down to after being completely dissolved；
(3) preservative, aloe extract, trehalose, vitamin E and grape are added in after temperature drops to 45-55 degrees Celsius to gather
Sugar stirs；
(4) snail mucus extract is added in after temperature is down to 35-45 degrees Celsius, it is equal with the rotating speed stirring of 20-50rpm
It is even；
(5) it is 7-8 to be eventually adding and regulate pH value with sodium hydroxide, and the rotating speed of 10-20rpm stirs evenly.
Cosmetics do not have ill effect to skin made of above-described embodiment, can effectively improve skin condition, make it
Activity recovery and elasticity, there are two moisturizing effects for tool, can effectively improve Skin Cell differentiation of self and replication capacity, former egg
It is white that there is the effect of keeping moisture, enhancing skin elasticity；Chondroitin sulfate is conducive to remove old cutin, reduce wrinkle of skin and
Scar；Boy's polypeptide has the function of that skin is stimulated to regenerate, lighten the stain, promoting skin quality and glossiness.Specific detection ginseng
As shown in Fig. 2-4, detection result is consistent with said extracted analyte detection effect.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (4)
1. a kind of snail mucus extract, which is characterized in that wherein containing chondroitin sulfate 1~3%, allantoin 1~3%, glue
Former albumen 1~6%, the molecular weight distribution of micromolecule polypeptide is in 4500 dalton；
The snail mucus extract is through the following steps that obtained：
(1) it extracts：White jade snail mucus is taken, adds in the water of 5~30 times of its quality, in 5~60 DEG C of temperature and 50~75Mpa pressure
Lower progress high-pressure homogenization historrhexis extracts 1~3 time；
(2) it centrifuges：High-pressure homogenization material obtained by (1) step is detached with centrifuge, centrifuge speed is 500-1300 revs/min
Clock collects clear liquid；
(3) micro-filtration：Clear liquid aperture is 0.1 μm -0.5 μm of microfiltration of ceramic membrane；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 6,000~50,000 dalton；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 80~2,000 dalton of molecular cut off, collects concentrate.
2. the preparation method of a kind of snail mucus extract according to claim 1, which is characterized in that it includes following step
Suddenly：
(1) it extracts：White jade snail mucus is taken, adds in the water of 5~30 times of its quality, in 5~60 DEG C of temperature and 50~75Mpa pressure
Lower progress high-pressure homogenization historrhexis extracts 1~3 time；
(2) it centrifuges：High-pressure homogenization material obtained by (1) step is detached with centrifuge, centrifuge speed is 500-1300 revs/min
Clock collects clear liquid；
(3) micro-filtration：Clear liquid aperture is 0.1 μm -0.5 μm of microfiltration of ceramic membrane；
(4) ultrafiltration：Micro-filtration dialyzate molecular cut off is the ultrafiltration membrane ultrafiltration of 6,000~50,000 dalton；
(5) nanofiltration：The NF membrane concentration of ultrafiltration dialysis liquid 80~2,000 dalton of molecular cut off, collects concentrate.
3. a kind of anti-apolexis composition, which is characterized in that it includes following parts by weight component：
4. a kind of anti-ageing face mask, which is characterized in that it includes following parts by weight component：
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Effective date of registration: 20190116 Address after: 510670 Unit 201-202, Second Floor, Area B, Guangzhou Innovation Base, 80 Luyue Road, Guangzhou High-tech Industrial Development Zone, Guangdong Province Patentee after: Luo Jie bio tech ltd, Guangzhou Address before: 510663 Unit 502-509 on the 5th floor of Area A and 602-611 on the 6th floor of Area C, 80 Lanyue Road, Guangzhou Science City, Guangdong Province Patentee before: Guangdong Baohua Test Center Co., Ltd. |