CN110787080A - Earthworm anti-wrinkle composition and application thereof - Google Patents
Earthworm anti-wrinkle composition and application thereof Download PDFInfo
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- CN110787080A CN110787080A CN201911064140.4A CN201911064140A CN110787080A CN 110787080 A CN110787080 A CN 110787080A CN 201911064140 A CN201911064140 A CN 201911064140A CN 110787080 A CN110787080 A CN 110787080A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses an earthworm anti-wrinkle composition, and belongs to the field of skin care products. The composition comprises the following substances in parts by mass: 1-5 parts of earthworm extract, 1-5 parts of snail mucus, 1-5 parts of avocado extract, 20-30 parts of Chinese honeylocust kernel extract, 0.01-0.1 part of sea cucumber extract, 1-20 parts of micromolecular hyaluronic acid, 5-15 parts of tocopherol and 10-25 parts of seaweed extract. The skin wrinkle-removing cream is compounded according to multiple mechanisms of skin wrinkle generation to obtain a formula combination with a synergistic effect, and the skin wrinkle-removing cream has the advantages of promoting the absorption of skin on nutrients, having strong oxidation resistance, shrinking pores, removing old cutin, promoting metabolism, accelerating cell regeneration, reducing skin wrinkles and repairing skin. The invention has simple production process, is suitable for large-scale production, and has the characteristics of good anti-wrinkle effect, safety, overall mild effect and the like.
Description
Technical Field
The invention relates to the field of skin care products, and in particular relates to an earthworm anti-wrinkle composition and application thereof.
Background
Earthworm is also called earthworm, is one of the important Chinese medicinal materials, and contains rich protein and polypeptide, such as lipoprotein, calmodulin binding protein, antimicrobial protein, antibiotic peptide, etc. and rich amino acids, so that it is found that earthworm contains 18 kinds of amino acids, including leucine, glutamic acid, aspartic acid, valine, lysine, arginine, alanine, glycine, serine, threonine, methionine, phenylalanine, proline, histidine, tyrosine, etc. and contains 8 kinds of free amino acids essential for human body. Has effects in promoting metabolism, inhibiting bacteria, and relieving inflammation.
Skin wrinkles are formed by folding the skin and excessive relaxation between the skin and its deep tissues due to the decrease of elastic fibers that maintain the normal tension of the skin, the decrease of sebaceous gland secretion, and the decrease of subcutaneous fat. Facial wrinkles are particularly common, and with the increase of age, the metabolism of the body is weakened, and aging wrinkles are gradually formed. Generally the forehead appears first, followed by the fishtail lines of the eyes and the smile lines of the cheeks. However, anti-wrinkle is also the key point of skin care, and the current anti-wrinkle technology mainly adopts vitamin E (tocopherol), vitamin A and yeast. Or improving skin by moisturizing and scavenging free radicals; does not have good anti-wrinkle effect.
Disclosure of Invention
The invention provides a composition for fading fine wrinkles and resisting wrinkles, which has a good anti-wrinkle effect, can promote cell metabolism, penetrate skin cells and regenerate skin.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the earthworm anti-wrinkle composition comprises the following substances in parts by mass: 1-5 parts of earthworm extract, 1-5 parts of snail mucus, 1-5 parts of avocado extract, 20-30 parts of Chinese honeylocust kernel extract, 0.01-0.1 part of sea cucumber extract, 1-20 parts of small molecular hyaluronic acid, 5-15 parts of tocopherol and 10-25 parts of seaweed extract.
Further, the earthworm anti-wrinkle composition consists of the following substances in parts by mass: 2-3 parts of earthworm extract, 1-2 parts of snail mucus, 3-5 parts of avocado extract, 25-30 parts of Chinese honeylocust kernel extract, 0.05-0.08 part of sea cucumber extract, 5-10 parts of small molecular hyaluronic acid, 5-10 parts of tocopherol and 15-20 parts of seaweed extract.
Further, the earthworm anti-wrinkle composition consists of the following substances in parts by mass: 2.3-2.8 parts of earthworm extract, 1.5-2 parts of snail mucus, 3.5-4.5 parts of avocado extract, 28-30 parts of Chinese honeylocust seed extract, 0.05-0.06 part of sea cucumber extract, 5-8 parts of small molecular hyaluronic acid, 5-8 parts of tocopherol and 15-18 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 30-60min, and cleaning;
(2) putting Lumbricus in 60-90% ethanol, treating with ultrasound for 30-60min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain earthworm protein.
Further, the avocado extract is an extract extracted by an aqueous enzymatic method.
Further, the preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing fructus Gleditsiae Abnormalis with deionized water, grinding, filtering to obtain filtrate, and sterilizing.
Further, the feed-liquid ratio of the saponin to the deionized water is 1: 0.5.
The invention also protects the application of the earthworm anti-wrinkle composition in skin care products.
Earthworm extract: according to the invention, the earthworm extract is a hydroalcoholic extract and is fused with flour, so that ash content in earthworm protein can be reduced, and the purity of the earthworm protein is improved. The earthworm protein contains abundant lipid protein and amino acid, can supplement nutrition for skin, promote metabolism and cell regeneration, and effectively resist wrinkle.
Snail mucus: the snail mucus has good moisture keeping and antiinflammatory effects, and contains natural collagen, elastin, allantoin, glucuronic acid, and multiple vitamins. The nutrients contained in the components are brought into the deep layer of the skin, so that the skin can be repaired, old cutin can be removed, cell regeneration can be accelerated, skin wrinkles can be reduced, and spots, scars and acnes on the skin can be eliminated; can increase skin nutrition; allantoin can supplement cell regeneration factor, and can rapidly regenerate skin; thereby restoring the softness, smoothness and fineness of the skin.
Avocado extract: the avocado contains rich glyceric acid, protein and vitamin, is a natural antioxidant anti-aging agent, can soften and moisten skin, can shrink pores, can form a milky isolation layer on the surface of the skin, can effectively resist sunlight irradiation, and can prevent sunburn and sunburn, so that the generation of fine wrinkles is reduced, and the avocado extract has good affinity with human skin, is easily absorbed by the skin, and has good anti-wrinkle effect.
And (3) extracting the Chinese honeylocust fruit kernels: the collagen-rich plant collagen can provide nutrients for skin, improve the tension and elasticity of the skin, repair damaged skin, keep the skin fine and smooth and lustrous, and can improve the collagen absorption of the skin and effectively resist wrinkles when being used together with hyaluronic acid and tocopherol.
Sea cucumber extract liquid: contains abundant proteins, and has effects of removing old cutin, accelerating cell regeneration, reducing skin wrinkle, and repairing skin.
Small molecule hyaluronic acid: is hyaluronic acid with molecular weight less than 10000Da, is easy to be absorbed by skin due to small molecular weight, and has effects of whitening skin, keeping moisture, resisting wrinkle, etc.
The tocopherol is hydrolysate of vitamin E (ve), natural tocopherol is d-tocopherol (D-tocopherol), which has 8 isomers such as α, β, upsilon, delta and the like, has good inoxidizability, can improve lipid metabolism, has anti-aging effect, and can promote the absorption of other components to nutrient substances together with Chinese honeylocust fruit kernels, sea cucumbers, earthworm extracts and snail extracts.
Extracting the seaweed: contains protein and vitamin E, and has effects of removing wrinkle, resolving macula, whitening skin, relieving inflammation, eliminating eye pouch wrinkle, and increasing nutrition and moisture, and makes skin elastic and youthful.
The earthworm anti-wrinkle composition has the beneficial effects that: the skin wrinkle-removing cream is compounded according to multiple mechanisms of skin wrinkle generation to obtain a formula combination with a synergistic effect, and the skin wrinkle-removing cream has the advantages of promoting the absorption of skin on nutrients, having strong oxidation resistance, shrinking pores, removing old cutin, promoting metabolism, accelerating cell regeneration, reducing skin wrinkles and repairing skin. The invention has simple production process, is suitable for large-scale production, and has the characteristics of good anti-wrinkle effect, safety, overall mild effect and the like.
Detailed Description
The present invention will be described in further detail with reference to the following examples.
Example 1
The earthworm anti-wrinkle composition comprises the following substances in parts by mass: 1 part of earthworm extract, 1 part of snail mucus, 1 part of avocado extract, 20 parts of Chinese honeylocust kernel extract, 0.05 part of sea cucumber extract, 1 part of micromolecular hyaluronic acid, 5 parts of tocopherol and 10 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 60min, and cleaning;
(2) putting Lumbricus in 60% ethanol, treating with ultrasound for 30min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
The preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing and grinding the saponin and the deionized water, wherein the material-liquid ratio is 1: 0.5; filtering to obtain filtrate, and sterilizing.
The preparation method of the sea cucumber extract and the seaweed extract comprises the steps of adding water, grinding to obtain colloid, filtering and removing the allergen.
Example 2
The earthworm anti-wrinkle composition comprises the following substances in parts by mass: 5 parts of earthworm extract, 5 parts of snail mucus, 5 parts of avocado extract, 30 parts of Chinese honeylocust kernel extract, 0.01 part of sea cucumber extract, 20 parts of micromolecular hyaluronic acid, 15 parts of tocopherol and 25 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 60min, and cleaning;
(2) putting Lumbricus in 90% ethanol, treating with ultrasound for 30min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
The preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing and grinding the saponin and the deionized water, wherein the material-liquid ratio is 1: 0.5; filtering to obtain filtrate, and sterilizing.
The preparation method of the sea cucumber extract and the seaweed extract comprises the steps of adding water, grinding to obtain colloid, filtering and removing the allergen.
Example 3
The earthworm anti-wrinkle composition comprises the following substances in parts by mass: 2 parts of earthworm extract, 2 parts of snail mucus, 3 parts of avocado extract, 25 parts of Chinese honeylocust kernel extract, 0.08 part of sea cucumber extract, 10 parts of micromolecular hyaluronic acid, 10 parts of tocopherol and 20 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 60min, and cleaning;
(2) putting Lumbricus in 80% ethanol, treating with ultrasound for 30min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
The preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing and grinding the saponin and the deionized water, wherein the material-liquid ratio is 1: 0.5; filtering to obtain filtrate, and sterilizing.
The preparation method of the sea cucumber extract and the seaweed extract comprises the steps of adding water, grinding to obtain colloid, filtering and removing the allergen.
Example 4
The earthworm anti-wrinkle composition comprises the following substances in parts by mass: 2 parts of earthworm extract, 2 parts of snail mucus, 3 parts of avocado extract, 25 parts of Chinese honeylocust kernel extract, 0.08 part of sea cucumber extract, 5 parts of micromolecular hyaluronic acid, 5 parts of tocopherol and 15 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 60min, and cleaning;
(2) putting Lumbricus in 70% ethanol, treating with ultrasound for 30min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
The preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing and grinding the saponin and the deionized water, wherein the material-liquid ratio is 1: 0.5; filtering to obtain filtrate, and sterilizing.
The preparation method of the sea cucumber extract and the seaweed extract comprises the steps of adding water, grinding to obtain colloid, filtering and removing the allergen.
Example 5
The earthworm anti-wrinkle composition comprises the following substances in parts by mass: 2.3 parts of earthworm extract, 1.5 parts of snail mucus, 3.5 parts of avocado extract, 28 parts of Chinese honeylocust kernel extract, 0.06 part of sea cucumber extract, 8 parts of small-molecule hyaluronic acid, 8 parts of tocopherol and 18 parts of seaweed extract.
The preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 60min, and cleaning;
(2) putting Lumbricus in 90% ethanol, treating with ultrasound for 30min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
The preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing and grinding the saponin and the deionized water, wherein the material-liquid ratio is 1: 0.5; filtering to obtain filtrate, and sterilizing.
The preparation method of the sea cucumber extract and the seaweed extract comprises the steps of adding water, grinding to obtain colloid, filtering and removing the allergen.
The earthworm anti-wrinkle composition is an additive of cosmetics, and the dosage is 5-10% (mass percentage).
Preparing the anti-wrinkle cream:
10 parts of earthworm anti-wrinkle composition, 5 parts of 1, 3-butanediol, 10 parts of glycerol, 1.5 parts of potassium sorbate, 0.5 part of phenoxyethanol, 0.5 part of perfume and 62.5 parts of deionized water;
adding 1, 3-butanediol, glycerol, phenoxyethanol, the anti-wrinkle earthworm composition and deionized water into a container, fully mixing at 50 ℃, adding potassium sorbate, mixing, finally adding perfume, fully mixing, and cooling to room temperature.
Preparing anti-wrinkle cream;
10 parts of earthworm anti-wrinkle composition, 2 parts of 1, 3-butanediol, 5 parts of glycerol, 1.5 parts of potassium sorbate, 0.5 part of phenoxyethanol, 0.5 part of perfume and 70.5 parts of deionized water;
adding 1, 3-butanediol, glycerol, phenoxyethanol, the anti-wrinkle earthworm composition and deionized water into a container, fully mixing at 50 ℃, adding potassium sorbate, mixing, finally adding perfume, fully mixing, and cooling to room temperature.
Preparing the anti-wrinkle toner:
5 parts of earthworm anti-wrinkle composition, 1.5 parts of potassium sorbate and 2 parts of 3-butanediol, and the components are mixed, slowly added with deionized water and stirred to be completely dissolved.
To determine the anti-wrinkle effect of the present invention;
the skin toner is prepared from 10% of earthworm extract, 10% of snail mucus, 10% of avocado extract, 10% of Chinese honeylocust kernel extract, 10% of sea cucumber extract, 10% of small-molecule hyaluronic acid, 10% of tocopherol and 10% of seaweed extract.
Fibroblasts were seeded into 12-well cell culture plates, each well containing 0.75 × 105 cells, and starved for 24 hours in serum-free medium. Starved cultured cells were washed with PBS and treated with uv light (40 mJ). Then, the test sample was added to the cells 2 times within 48 hours. MMP-1 isolated from the medium was measured using a kit (BIOTRAK, RPN 2610). Evaluating the strength of the anti-wrinkle effect by calculating the expression inhibition rate of MMP-1;
TABLE 1 inhibition of MMP-1 expression by different test samples
As can be seen from the above table, the inhibition rate of example 5, i.e. the present invention, is significantly higher than that of other groups of samples, which fully demonstrates that several components interact synergistically to improve the anti-wrinkle effect under the condition of mixing.
The technical solutions provided by the embodiments of the present invention are described in detail above, and the principles and embodiments of the present invention are explained herein by using specific examples, and the descriptions of the embodiments are only used to help understanding the principles of the embodiments of the present invention; meanwhile, for a person skilled in the art, according to the embodiments of the present invention, there may be variations in the specific implementation manners and application ranges, and in summary, the content of the present description should not be construed as a limitation to the present invention.
Claims (8)
1. An earthworm anti-wrinkle composition is characterized in that: the composition comprises the following substances in parts by mass: 1-5 parts of earthworm extract, 1-5 parts of snail mucus, 1-5 parts of avocado extract, 20-30 parts of Chinese honeylocust kernel extract, 0.01-0.1 part of sea cucumber extract, 1-20 parts of micromolecular hyaluronic acid, 5-15 parts of tocopherol and 10-25 parts of seaweed extract.
2. The earthworm anti-wrinkle composition according to claim 1, wherein: the composition comprises the following substances in parts by mass: 2-3 parts of earthworm extract, 1-2 parts of snail mucus, 3-5 parts of avocado extract, 25-30 parts of Chinese honeylocust kernel extract, 0.05-0.08 part of sea cucumber extract, 5-10 parts of micromolecular hyaluronic acid, 5-10 parts of tocopherol and 15-20 parts of seaweed extract.
3. The earthworm anti-wrinkle composition according to claim 1, wherein: the composition comprises the following substances in parts by mass: 2.3-2.8 parts of earthworm extract, 1.5-2 parts of snail mucus, 3.5-4.5 parts of avocado extract, 28-30 parts of Chinese honeylocust seed extract, 0.05-0.06 part of sea cucumber extract, 5-8 parts of small molecular hyaluronic acid, 5-8 parts of tocopherol and 15-18 parts of seaweed extract.
4. The earthworm anti-wrinkle composition according to any one of claims 1 to 3, wherein: the preparation method of the earthworm extract comprises the following steps:
(1) soaking fresh Lumbricus in clear water for 24 hr to remove foreign matters such as soil in intestinal tract, and decomposing cleaned Lumbricus into 1-2cm segments; mixing with flour, standing for 30-60min, and cleaning;
(2) putting Lumbricus in 60-90% ethanol, treating with ultrasound for 30-60min, and filtering to obtain filtrate; concentrating the filtrate and drying to obtain Lumbricus extract.
5. The earthworm anti-wrinkle composition according to claim 1, wherein: the avocado extract is extracted by an aqueous enzymatic method.
6. The earthworm anti-wrinkle composition according to claim 1, wherein: the preparation method of the Chinese honeylocust fruit kernel extract comprises the following steps: mixing fructus Gleditsiae Abnormalis with deionized water, grinding, filtering to obtain filtrate, and sterilizing.
7. The earthworm anti-wrinkle composition according to claim 6, wherein: the feed-liquid ratio of the saponin to the deionized water is 1: 0.5.
8. An application of the earthworm anti-wrinkle composition containing any one of 1-3 in skin care products.
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| CN201911064140.4A CN110787080A (en) | 2019-11-04 | 2019-11-04 | Earthworm anti-wrinkle composition and application thereof |
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| CN201911064140.4A CN110787080A (en) | 2019-11-04 | 2019-11-04 | Earthworm anti-wrinkle composition and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416825A (en) * | 2001-11-11 | 2003-05-14 | 渝州大学 | Active earthworm decoction and its prepn |
| CN102525866A (en) * | 2012-01-11 | 2012-07-04 | 山东大学威海分校 | Cosmetic additive, and preparation method and application thereof |
| CN104042548A (en) * | 2014-06-26 | 2014-09-17 | 广东省保化检测中心有限公司 | Snail grume extract as well as preparation method and application thereof in cosmetics |
| CN105997830A (en) * | 2016-07-22 | 2016-10-12 | 杨凌三度蚯蚓科技有限公司 | Nutritional anti-wrinkle cream made of earthworm extract |
-
2019
- 2019-11-04 CN CN201911064140.4A patent/CN110787080A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416825A (en) * | 2001-11-11 | 2003-05-14 | 渝州大学 | Active earthworm decoction and its prepn |
| CN102525866A (en) * | 2012-01-11 | 2012-07-04 | 山东大学威海分校 | Cosmetic additive, and preparation method and application thereof |
| CN104042548A (en) * | 2014-06-26 | 2014-09-17 | 广东省保化检测中心有限公司 | Snail grume extract as well as preparation method and application thereof in cosmetics |
| CN105997830A (en) * | 2016-07-22 | 2016-10-12 | 杨凌三度蚯蚓科技有限公司 | Nutritional anti-wrinkle cream made of earthworm extract |
Non-Patent Citations (3)
| Title |
|---|
| 周晓孟 等: "《国人必知的2300中华饮食文化常识》", 31 December 2009, 万卷出版公司 * |
| 王继生: "《皮肤病实用中药学 下》", 31 May 2010, 河北大学出版社 * |
| 陈培毅: "《身体缺的不是药 是营养》", 31 October 2016, 吉林科学技术出版社 * |
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Application publication date: 20200214 |