CN104039338A - 植物性抗微生物组合物 - Google Patents
植物性抗微生物组合物 Download PDFInfo
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- CN104039338A CN104039338A CN201280064657.3A CN201280064657A CN104039338A CN 104039338 A CN104039338 A CN 104039338A CN 201280064657 A CN201280064657 A CN 201280064657A CN 104039338 A CN104039338 A CN 104039338A
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Abstract
本发明公开了含有有效抗微生物低浓度苯甲醇、一种或多种精油以及一种或多种植物提取物的组合物。本发明的组合物可用于包括伤口护理产品在内的个人护理产品和兽用产品。在某些实施例中,组合物具有绝大部分或基本全部源于自然资源的抗微生物活性剂,因此,避免用户使用到刺激性和/或有毒化学物质。这特别益于儿童或宠物使用,或者在家庭中或其他有儿童或宠物的环境中使用。
Description
优先权声明
本申请是2012年3月5日提交的美国专利申请13/412,464的部分继续申请,要求以下美国临时申请的优先权:2011年11月3日提交的美国临时申请61/555,367,2011年12月6日提交的美国临时申请61/567,372,2012年1月5日提交的美国临时申请61/583,482,2012年1月5日提交的美国临时申请61/583,505,以及2012年1月6日提交的美国临时申请61/583,998,本申请要求以上各申请的优先权,以上各申请的全部内容通过引用并入本文。
技术领域
本申请公开了含有苯甲醇、精油和植物提取物(包括植物提取物和果实提取物)有效抗菌组合的组合物。
背景技术
精油是从植物源或动物源得到的挥发油,有多种成分,例如单萜和倍半萜烃类、单萜和倍半萜醇类、酯类、醚类、醛类、酮类、氧化物等的复杂混合物组成。这些精油及其分离成分常常用作香料和调味剂,并广泛使用于治愈伤口的民间医药。
科学研究已经证实了精油的有益效果。人们发现桉树精油“具有中枢和外周止痛作用以及依赖或不依赖嗜中性粒细胞的消炎活性”(Silva等,2003,J.Ethnopharmacol.89(2-3);277-283),在来自薰衣草的精油中观察到类似的活性(Hajhashemi等,2003,J.Ethnopharniacol.89(1):67~71)。有证据证明,精油具有抗菌(Bezic等,2003,Phytother.Res.17(9:1037-1040;Goren等,2003,Z.Naturforsch.58(9-10):687-690;de Abreu Gonzaga等,2003,Planta Med.69(8:773-775;Valero和Salmera,2003,Int.J.Food Microbiol.85(1-2):73-81)和抗真菌(Paranagama等,2003,Lett.Appl.Microbiol.37(l);86-90;Shin,2003,Arch.Pharm.Res.26(5):389-393;Velluti等,2003,Int.J.Food Microbiol.89:145-154)活性。还观察到了精油的抗病毒活性,包括对1型和2型单纯疱疹病毒的直接抗病毒效果(Garcia等,Phytother.Res.17(9):1073-1075;Minami等,2003,Microbial Immunol.47(a):681-684;Schuhmacher等,2003,Phytomedicine10:504-510)。
公开号为20050048139的美国专利申请(于2005年3月3日公布,发明人为莫达克等)涉及含有润滑剂和精油的局部用组合物,该组合物还含有其它添加剂,例如柠檬酸、乙醇酸和乳酸。
公开号为20050019431的美国专利申请(于2005年1月27日公布,发明人为莫达克等)涉及含有季铵化合物和精油(或其活性成分)的组合物。
有大量专利申请涉及含有精油(或其成分)的组合物,在这些组合物中,添加了锌盐以防止由精油导致的疼痛。这些专利申请的实例包括公开号为2004102429的美国专利申请(于2004年5月27日公布,发明人为莫达克等)和公开号为20050238602的美国专利申请(于2005年10月27日公布,发明人为莫达克等)以及当时公布的美国专利7,435,429。
美国专利6,858,317(于2005年2月22日发布,发明人为Aamodt等)涉及使用无毒霉菌抑制剂防止木材受到霉菌和边材变色真菌感染的方法,所述无毒霉菌抑制剂可为植物提取物,例如精油。
美国专利5,100,652(于1992年3月31日发布,发明人为Kross等)涉及形成口腔卫生组合物的低浓度亚氯酸,其含有作为调味剂的精油。
美国专利5,310,546(于1994年5月10日发布,发明人为Douglas)涉及一种漱口剂,其含有过氧化氢、氯化锌、柠檬酸钠、月桂基硫酸钠、柠檬酸和乙醇,也可选择加入精油作为变性剂。
BION提供了几种局部用皮肤护理产品,其含有柠檬酸、植物制剂和其他制剂(美国加利福尼亚州圣迭戈)。
Johnson等(美国专利6,319,958和美国专利US20020165130)涉及采用倍半萜化合物促进对外源性抗微生物化合物的摄取。类似的,一篇相关论文提示了采用倍半萜化合物,如橙花叔醇、法尼醇、没药醇和阿普利酮(apritone)提高细菌穿透性和对外源性抗微生物化合物的易感性,表明倍半萜化合物具有非特异性和普遍的效果(Brehm-Stecher等,Antimicrobial Agents and Chemotherapy,47(10):3357-3360)。具体说,Brehm-Stecher等的报告提出,橙花叔醇、法尼醇、没药醇和阿普利酮提高了金黄色葡萄球菌对抗生素红霉素、庆大霉素、万古霉素、环丙沙星(ciproflaxin)、氯林可霉素和四环素的易感性。
美国专利4,867,898(于1989年9月19日发布,发明人为Spaulding等)涉及一种硬表面液体清洁剂,其含有松树油和pH值为0-6的油溶性有机酸。
美国专利6,753,305(于2004年6月22日发布,发明人为Raso和Caselli)涉及一种硬表面消毒剂,其含有多达20%的肉桂油或其一种成分、0.01-5%的有机酸,以及可选择性加入的其他精油。
公开号为WO2007077573的国际专利申请(于2007年7月12日公布,发明人为Mukhopadhyay)涉及抗微生物组合物,其含有一种例如三氯生的抗微生物剂和官能化烃和/或溶剂,其中,官能化烃可以是一种精油。
感染仍然是处理病人烧伤创面、褥疮和其他表面感染中的主要问题。在防止细菌血症和促进伤口愈合中控制皮肤感染是最为重要的。已经开发出含有磺胺嘧啶银盐的局部用药膏和其它局部用抗微生物剂并广泛使用于上述目的。但是,这些制剂的使用并未达到完全控制目标感染。
作为预防药膏,1%磺胺嘧啶银盐乳膏已有效地用来控制烧伤创面感染。但是,由于药物不能渗入伤口焦痂,它对于治疗已经形成的深部感染效果不是十分有效。在用进行治疗的患者中有伤口被金黄色葡萄球菌和白色念球菌感染的发生,这促使我们不得不进行开发其它制剂的研究。
已经证实,对感染的持续控制有利于II度烧伤、褥疮和其他类型外伤创面的快速愈合和封口。伤口愈合,尤其是烧伤创面愈合,是一个复杂的过程,已经发现锌在这个过程中具有重要作用。对于锌的研究表明,锌可加速表皮再植进程,对创面愈合具有有益效果,并且具有抗菌效果。有报告称,锌可激活内源性锌依赖基质金属蛋白酶、增强内源性生长因子的表达以及促进角质形成细胞的游走。
在早期研究中发现,使用磺胺嘧啶锌对烧伤创面进行表面处理在加速创面愈合方面好于磺胺嘧啶银盐(Gyn and Obstet,142:553-559(1976))。
已使用局部用软膏来防止或减少烧伤创面感染。这些软膏含有磺胺嘧啶银盐(美国专利3761590,通过引用并入本文)或各种抗生素。据报道,有一种局部用软膏还含有银盐和诺氟沙星、喹啉抗生素或其盐的组合(美国专利4404197,通过引用并入本文)。当抗生素为诺氟沙星银时,美国专利4404197报告活性协同增强。美国专利5374432涉及含有抗生素、银盐和无菌载体的局部用抗感染软膏。这些组合物不仅具有改进的抗菌功效,还降低了微生物产生抗性的发生几率。
美国专利6987133涉及一种含有磺胺嘧啶银盐的局部用制剂,所述磺胺嘧啶银盐散布或溶解于可直接涂抹于烧伤创面上的乳膏或洗液基质中。欧洲专利EP0653214涉及一种含有磺胺嘧啶银盐和胶原蛋白的局部用抗菌制剂,用于治疗手部感染及促进其愈合。
在各种专业和非专业应用领域中,一直需要一种重复使用的无刺激性、安全和有效的抗微生物组合物或伤口愈合组合物。
发明内容
本发明公开了含有有效抗微生物低浓度苯甲醇、一种或多种精油、以及一种或多种植物提取物的组合物,在一些实施例中,组合物具有绝大部分或基本全部源于自然资源的抗微生物活性剂,因此,避免用户使用到刺激性和/或有毒化学物质。这特别益于儿童或宠物使用,或者在家庭中或其他有儿童或宠物的环境中使用。
在某些实施例中,抗微生物组合物含有苯甲醇(约0.1%(重量比)至10%(重量比))、一种或多种精油例如但不限于香茅草油、肉桂油、百里香油、高良姜油、橙油、石榴油、咖哩叶油、以及它们的组合(约0.02%(重量比)至1.0%(重量比)),以及一种或多种植物提取物例如山葵提取物、葡萄柚籽提取物、金银花提取物、雪松木提取物、石榴提取物、紫松果菊属提取物、山杨树皮提取物、柳树皮提取物、柑橘属提取物、布拉米(Brahmi)提取物、以及它们的组合(约0.1%(重量比)至1.0%(重量比))。选择性添加成分包括一种或多种倍半萜例如法尼醇、橙花叔醇、没药醇、阿普利酮(apritone)、柠檬醛、以及它们的组合(约0.03%(重量比)至2%(重量比))、一种或多种植物性醇(约5%(重量比)至20%(重量比))、一种或多种天然有机酸例如果酸、苯甲酸、水杨酸、以及它们的组合(0.02%(重量比)至2.0%(重量比))、以及蔬菜甘油。
本文所用术语“约”是指列举值±20%。
本文中的所有范围包括列举值。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.5%(重量比)至50%(重量比)苯甲醇;
(b)约0.01%(重量比)至5%(重量比)精油;以及
(c)约0.1%(重量比)至4%(重量比)倍半萜,
其中,所述组合物不包含烷二醇。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.5%(重量比)至50%(重量比)苯甲醇;
(b)约0.01%(重量比)至5%(重量比)精油;
(c)约0.5%(重量比)至10%(重量比)植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、金银花提取物、雪松木提取物、山杨树皮提取物、柳树皮提取物、烟草提取物、以及它们的组合。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.5%(重量比)至50%(重量比)苯甲醇;
(b)约0.01%(重量比)至5%(重量比)精油;
(c)约0.5%(重量比)至10%(重量比)植物提取物;
(d)约0至20%(重量比)果酸;
(e)约0.1%(重量比)至4%(重量比)倍半萜,
其中,所述组合物不包含烷二醇。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.5%(重量比)至2.0%(重量比)苯甲醇;
(b)约0.5%(重量比)至4.0%(重量比)特殊阳离子复合物(incroquat);
(c)约0.2%(重量比)至0.5%(重量比)苯甲酸;
(d)约0.05%(重量比)至1%(重量比)的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油(例如肉桂叶油或桂皮油)、高良姜油、石榴油和香茅草油;以及
(e)约0.2%(重量比)至2.0%(重量比)的一种或多种植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、芦荟凝胶和芦荟叶汁。在本实施例的某些子集中,所述组合物还包含约0.1%(重量比)至0.5%(重量比)的氧化锌。在本实施例的某些子集中,所述组合物还包含约0.2%(重量比)至0.5%(重量比)的苯甲酸钠。在本实施例的某些子集中,所述组合物还包含约0.1%(重量比)至1.0%(重量比)的戊二醇。在本实施例的某些子集中,所述组合物还包含葡萄柚籽或另一种柑橘提取物,例如,其浓度约为0.3%(重量比)至1.0%(重量比)。在本实施例的某些子集中,所述组合物还包含一种或多种维生素E和/或维生素C,例如,各浓度约为0.02%(重量比)至0.2%(重量比)。在本实施例的某些子集中,所述组合物还包含倍半萜或倍半萜混合物,例如,其浓度约为0.3%(重量比)至2.0%(重量比)时。在本实施例的某些子集中,所述组合物不包含为双胍、氯代苯酚、或季铵化合物的抗菌剂或杀菌剂。在本实施例的某些子集中,所述组合物不包含苯基乙醇。在本实施例的某些子集中,所述组合物不包含苯氧乙醇。在本实施例的某些子集中,所述组合物不包含多粘菌素、咪康唑、氟康唑、伊康唑(itriconazole)或酮康唑。在本实施例的某些子集中,所述组合物不包含新霉素。在本实施例的某些子集中,所述组合物不包含杆菌肽。在本实施例的某些子集中,所述组合物不包含聚维酮碘或其他含碘化合物。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.1%(重量比)至2.0%(重量比)苯甲醇;
(b)约0.1%(重量比)至2.0%(重量比)苯甲酸;
(c)约0.5%(重量比)至1.0%(重量比)苯氧乙醇;
(d)约0.3%(重量比)至1.3%(重量比)倍半萜,其形式为单一倍半萜或倍半萜类混合物;
(e)约0.05%(重量比)至2.5%(重量比)的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油(例如肉桂叶油或桂皮油)、高良姜油、石榴油和香茅草油;以及
(f)约0.2%(重量比)至2.0%(重量比)的一种或多种植物制剂,所述植物制剂选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、芦荟凝胶和芦荟叶汁。在本实施例的某些子集中,所述组合物还包含约0.5%(重量比)至3.0%(重量比)的戊二醇。在本实施例的某些子集中,所述组合物还包括约0.5%(重量比)至2.0%(重量比)的阳离子表面活性剂。在本实施例的某些子集中,所述组合物不包含为双胍、氯代苯酚、或季铵化合物的抗菌剂或杀菌剂。在本实施例的某些子集中,所述组合物不包含苯基乙醇。在本实施例的某些子集中,所述组合物不包含多粘菌素、咪康唑、氟康唑、伊康唑(itriconazole)或酮康唑。在本实施例的某些子集中,所述组合物不包含新霉素。在本实施例的某些子集中,所述组合物不包含杆菌肽。在本实施例的某些子集中,所述组合物不包含聚维酮碘或其他含碘化合物。
在某些非限制性实施例中,抗微生物组合物包含:
(a)约0.1%(重量比)至2.0%(重量比)苯甲醇;
(b)约0.02%(重量比)至2.0%(重量比)苯甲酸;
(c)约0.1%(重量比)至1.0%(重量比)苯基乙醇;
(d)约0.02%(重量比)至1%(重量比)倍半萜,其形式为单一倍半萜或倍半萜类混合物;
(e)约0.05%(重量比)至2.5%(重量比)的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油(例如肉桂叶油或桂皮油)、高良姜油、石榴油和香茅草油;以及
(f)约0.05%(重量比)至2.0%(重量比)的一种或多种植物制剂,所述植物制剂选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、芦荟凝胶和芦荟叶汁。在本实施例的某些子集中,所述组合物不包含为双胍、氯代苯酚、或季铵化合物的抗菌剂或杀菌剂。在本实施例的某些子集中,所述组合物不包含苯氧乙醇。在本实施例的某些子集中,所述组合物不包含多粘菌素、咪康唑、氟康唑、伊康唑(itriconazole)或酮康唑。在本实施例的某些子集中,所述组合物不包含新霉素。在本实施例的某些子集中,所述组合物不包含杆菌肽。在本实施例的某些子集中,所述组合物不包含聚维酮碘或其他含碘化合物。
在某些非限制性实施例中,消毒剂包含:
(a)约0.5%(重量比)至3.0%(重量比)苯甲醇;
(b)约0.05%(重量比)至2.5%(重量比)香茅草油、橙油、或它们的组合;
(c)约0.1%(重量比)至2.0%(重量比)果酸;
(d)约0.1%(重量比)至2.0%(重量比)植物制剂,所述植物制剂选自由山葵提取物和金银花提取物组成的集合。
在某些非限制性实施例中,伤口愈合组合物包含:
(a)约0.1%(重量比)至0.5%(重量比)苯甲醇;
(b)约0.2%(重量比)至1.0%(重量比)氧化锌;
(c)约0.05%(重量比)至0.7%(重量比)姜黄素;以及
(d)以下物质中至少两种:石榴油、迷迭香油、香茅草油、肉桂油(例如肉桂叶油或桂皮油)、百里香酚和药鼠李油,每种物质含量约0.1%(重量比)至1.0%(重量比)。
在某些非限制性实施例中,表面消毒剂包含:
(a)约1.0%(重量比)至30%(重量比)苯甲醇;
(b)约0.1%(重量比)至4.0%(重量比)的松树油和精油混合物,所述精油选自由以下物质组成的集合:香茅草油、橙油、肉桂叶油、桂皮油以及它们的组合;
(c)约2%(重量比)至10%(重量比)果酸;
(d)约5%(重量比)至25%(重量比)表面活性剂;以及
(e)水;可选择地,还包含3%(重量比)至50%(重量比)脂肪醇(例如但不限于脂肪醇混合物,例如乙醇和丙醇或丁醇混合物,例如SDA3C或SDA40B)。
在某些非限制性实施例中,表面消毒剂包含:
约2.5%(重量比)至10%(重量比)精油,所述精油选自由以下物质组成的集合:香茅草油、橙油、肉桂叶油、肉桂油以及它们的组合;
约0.5%(重量比)至5.0%(重量比)松树油;
约25%(重量比)至50%(重量比)表面活性剂;
约10%(重量比)至20%(重量比)果酸;
约20%(重量比)至40%(重量比)脂肪醇;以及水。
在某些非限制性实施例中,一种清洁组合物包含约1%(重量比)至5%(重量比)香茅草油、约0.1%(重量比)至1%(重量比)松树油以及约5%(重量比)至20%(重量比)柠檬酸。
在不同的非限制性实施例中,所述组合物可应用于例如肥皂、洁面乳、化妆品、外用乳膏和洗液等个人护理产品、伤口护理产品、烧伤创面膏、褥疮膏(含有抗炎植物制剂并使用磺胺嘧啶银盐作为抗微生物剂)、速效皮肤消毒剂、消毒巾以及兽用产品,例如用于治疗乳腺炎的抗微生物洗液、***浸液以及治疗软膏。本发明组合物在个人护理产品或局部用乳膏中的使用浓度约为1%至10%。在其他非限制性实施例中,所述组合物可在家庭和工业应用中使用,例如表面活性剂、表面清洁剂、杀虫剂和防腐剂。
具体实施方式
为描述清楚起见,但并非限制本发明,将本申请的具体实施方式分为以下几个部分:
(4.1)苯甲醇;
(4.2)精油;
(4.3)植物提取物;
(4.4)倍半萜;
(4.5)烷二醇;
(4.6)溶剂;
(4.7)天然有机酸;
(4.8)个人护理产品;
(4.9)伤口愈合;
(4.10)兽用产品;
(4.11)家庭/工业产品;
(4.12)医疗设备;以及
(4.13)杀虫剂
4.1苯甲醇
本文公开的组合物包含苯甲醇,浓度(%(重量/重量),“%(W/W)”)约为0.05%(W/W)至60%(W/W),或约0.5%(W/W)至50%(W/W),或约0.5%(W/W)至50%(W/W);或约0.5%(W/W)至2.0%(W/W),或约0.1%(W/W)至2.0%(W/W),或约0.1%(W/W)至0.5%(W/W),或约0.5%(W/W)至5%(W/W),或约5.0%(W/W)至20%(W/W),包括但不限于约为0.05%(W/W)、0.1%(W/W)、0.5%(W/W)、1.0%(W/W)、2.0%(W/W)、3.0%(W/W)、4.0%(W/W)、5.0%(W/W)、6.0%(W/W)、7.0%(W/W)、8.0%(W/W)、9.0%(W/W)、10.0%(W/W)、12%(W/W)、15%(W/W)、18%(W/W)、20%(W/W)、25%(W/W)、30%(W/W)、35%(W/W)、40%(W/W)、45%(W/W)、50%(W/W)、55%(W/W)和60%(W/W)。
在某些非限制性实施例中,本文公开的组合物包含苯甲醇,浓度约为0.1至0.5%w/w;或者约为0.1至0.45%w/w;或者约为0.1至0.4%w/w;或者约为0.1至0.35%w/w;或者约为0.1至0.3%w/w;或者约为0.1至0.25%w/w;或者约为0.1至0.2%w/w;或者约为0.1至0.15%w/w。
本文公开的组合物所使用的苯甲醇可用合成方法制成或由一种或多种天然植物(植物性)源获得。
4.2精油
本文所述的精油(“EO”)是获自植物或动物来源的挥发油,或其合成等价物,由多种成分,如单萜和倍半萜烃类,单萜和倍半萜醇、酯、醚、醛、酮、氧化物等的复杂混合物组成。EO的例子包括但不限于:肉桂油(例如肉桂叶油或桂皮油)、罗勒油、香柠檬油、香紫苏油、依兰油、橙花油、檀木油、兰丹油、姜油、薄荷油、薰衣草油、茉莉油、香叶油波旁、留兰香油、丁香油、广藿香油、迷迭香油、玫瑰木油、檀木油、茶树油、香草油、香茅草油、牛至油、百里香酚、高良姜油、雪松木油、香脂树油、红桔油、扁雪松油、油、亥巴油(Hiba oil)、银杏油(ginkooil)、按叶油、柠檬油、橙油、甜橙油、石榴籽油、石榴油、麦卢卡树油、香茅油、咖喱叶油和金盏花油。
精油的单个成分(“IC”)可以是从(天然)油中分离的,或完全或部分化学合成的,包括但不限于:百里香、牛至、姜黄素、1-香茅醇、α-戊基肉桂醛、新铃兰醛(lyral)、香叶醇、法尼醇、羟基香茅醛、异丁子香酚、丁子香酚、樟脑、桉树脑、芳樟醇、柠檬醛、百里香酚、柠檬烯和薄荷醇。IC的其他例子包括倍半萜化合物,它们可以是精油中的活性化合物。从3个5-碳异戊二烯单元通过生物合成形成含有15个碳的倍半萜化合物。倍半萜化合物包括但不限于:法尼醇、橙花叔橙、没药醇、阿普利酮、母菊薁、檀香脑、姜醇、胡萝卜醇和石竹烯。
本发明包括一种或多种EO和一种或多种IC的混合物、一种或多种EO以及一种或多种IC。在本发明某些具体的非限制性实施例中,IC选自由以下物质组成的集合(非限制性):樟脑、姜黄素、α-蒎烯、肉桂叶油组分例如肉桂醛、肉桂酰乙酸酯、肉桂酸、肉桂酸乙酯、甲基黑椒酚、芳樟醇、β-石竹烯和丁香油酚;香茅草油组分例如d-柠檬油精、乙酸香叶酯、橙花醇、香叶醇、柠檬醛和/或月桂烯;香茅油组分例如香叶醇、香茅醇、香茅醛、乙酸香叶酯、柠檬烯、甲基异丁香酚和/或榄香醇;罗勒油成分例如樟脑、柠檬烯、和/或β-芹子烯;以及橙油组分例如α-蒎烯、香桧烯、月桂烯、柠檬烯、芳樟醇、香茅醛、橙花醛和/或香叶醛。本申请所使用的EO或IC可由其天然源获得也可化学合成而得。
在本申请的优选非限制性实施例中,EO选自由以下物质组成的集合中的一种或多种EO:肉桂油(CO)(皮或叶)、香茅草油(LGO)以及罗勒油(BO),上述物质几乎没有香味或是无香油,例如石榴籽油(PSO)。
金盏花含有大量类黄酮,这种植物性抗氧化剂保护人体细胞免受自由基的破坏。它具有抗炎、抗病毒和抗菌效果。动物研究显示,金盏花可能通过增加流向受伤区域的血流量来帮助身体产生胶原蛋白以此促进伤口愈合,因此用于使皮肤和***愈合。
4.3植物提取物
本文所述的植物提取物包括植物、草药和果实提取物,其并非上述的“精油”。本发明使用的植物提取物包括但不限于山葵、金银花、雪松木、山杨树皮、柳树皮、布拉米(假马齿苋)提取物、柑桔提取物、茶树(绿茶)、葡萄、石榴、紫松果菊、积雪草、接骨木、爱尔兰藓、锦葵、皂皮、丝兰、香紫苏、牛至、百里香、姜黄素化合物、白藜芦醇(来源于葡萄、浆果等的多酚化合物)、岩兰草以及它们的混合物。用于获取植物提取物的植物可以是植物的任何一个部分,包括叶、果肉、籽,或者茎、果实以及果实籽,也可以是整株植物。草药提取物可以是,例如分散于和/或溶解于水介质中的标准提取物。
草药提取物实例包括但不限于洋甘菊、迷迭香、芦荟、荨麻、积雪草、银杏、桦木和金缕梅。这些提取物可在例如水、丙二醇、水醇、甘油或丁二醇等载体中运送。可使用其他具有营养功效的提取物,包括但不限于绿茶、白茶、葡萄皮、葡萄籽、白藜芦醇葡萄柚、葡萄柚籽、葡萄柚皮、柑橘果实(除葡萄柚提取物)、越橘、草莓、银杏、大豆异黄酮、大豆提取物、发酵大豆蛋白、黑升麻、金丝桃、紫松果菊、洋甘菊、迷迭香、芦荟提取物和汁液、荨麻、椰果和积雪草。植物提取物可从例如Active Organics(美国德克萨斯州希尔斯伯勒镇)、New Age Botanicals(美国德克萨斯州加兰镇)、Triarco Industries(美国新泽西州韦恩镇)和Aloecorp(美国科罗拉多州布鲁姆菲尔德镇)获得。
无香味植物实例包括但不限于石榴籽油(PSO)、可食用植物提取物Kefiprotect(KP)和四氢类姜黄素(THC)。有文献记载,姜黄和姜黄素具有抗炎性、抗氧化性和伤口愈合功效。以下姜黄素可用于局部用乳膏:四氢化姜黄素、四氢化去甲氧基姜黄素、四氢化双去甲氧基姜黄素、以及它们的混合物。植物提取物其他实例包括但不限于椰子,从椰子中可获得磷脂(Arlasik phospholipid PTM)、与角质层中脂肪酸酷似的天然脂肪酸混合物、具有天然色素如胡萝卜素、类胡萝卜素或植物甾醇的脂肪酸混合物等,这些物质有助于修复皮肤损伤。有效的植物提取物具体实例包括鳄梨,其含有甾醇、谷甾醇;胡萝卜,其含有β-胡萝卜素;芝麻油,其含有饱和及不饱和脂肪酸混合物,以及巴西坚果油。由于含有的脂肪酸种类多,提取物如巴西坚果油在与脂质层状结构结合方面优于单一脂肪酸。巴西坚果油(BNO)来源于南美洲热带雨林树木巴西坚果树结出的果实。
植物提取物还包括类黄酮和萜类化合物。本发明所述的类黄酮包括但不限于芦丁、槲皮素、橙皮苷和柚皮苷。本发明所述的萜类化合物包括但不限于单萜、倍半萜烯和二萜。
在本发明优选非限制性实施例中,植物提取物选自由以下物质组成的集合中的一种或多种:葡萄柚籽提取物(GSE)、石榴籽油(PSO)、柑橘果实提取物或可食用植物提取物Kefiprotect(PK)、含有磷脂(Arlasik phospholipid PTM)的椰子和四氢类姜黄素(THC)的混合物。
4.4倍半萜
本文公开的组合物包含一种或多种倍半萜,选自由以下物质组成的集合:法尼醇、橙花叔醇、没药醇、阿普利酮、柠檬醛、以及它们的组合。
4.5烷二醇
在非限制性实施例中,根据本发明可使用的双官能团醇类为烷二醇。适宜的烷二醇包括但不限于丙二醇、丁二醇、十二烷二醇、癸二醇、壬二醇、辛二醇、庚二醇、己二醇、以及戊二醇。
在特别的非限制性实施例中,烷二醇具有一个3至25个碳原子的碳骨架,包括但不限于1,9-壬二醇、1,2-癸二醇、1,10-癸二醇、1,11-十一烷二醇、1,2-十二烷二醇、1,2-十二烷二醇、1,12-十二烷二醇、环十二烷二醇、1,13-十三烷二醇、1,2-十四烷二醇、1,14-十四烷二醇、1,15-十五烷二醇、1,16-十六烷二醇、1,17-十七烷二醇、1,18-十八烷二醇、1,19-十九烷二醇、1,20-二十烷二醇、1,21-二十一烷二醇、1,22-二十二烷二醇、1,23-二十三烷二醇、1,24-二十四烷二醇、1,25-二十五烷二醇。
在某些实施例中,烷二醇由天然产品中获得。在某些实施例中,烷二醇由化学合成而得。
4.6溶剂
在不同的非限制性实施例中,本发明组合物包含一种或多种溶剂,包括但不限于选自由以下物质组成的集合:水、醇类、植物源醇类、二醇类、丙三醇、甘油、辛氧基甘油、双甘油、丙二醇、二丙二醇、以及蔬菜油。
优选但非限制性的溶解用非烷二醇实例是脂肪醇,其具有1至8个碳原子,例如甲醇、乙醇、正丙醇、异丙醇、2-甲基-2-丙醇、己醇或它们的组合。芳香醇,例如但不出于限制目的,苯氧乙醇、苯甲醇、1-苯氧基-2-丙醇以及/或者苯乙醇,也可选择性地与脂肪醇结合使用。
芳香醇,例如但不出于限制目的,包括苯氧乙醇、苯甲醇、1-苯氧基-2-丙醇以及/或者苯乙醇,例如,在浓度为0.5%至5%(重量比)时也可选择性地与脂肪醇结合使用。本发明组合物可选择地包含另一种溶剂为豆蔻酸异丙酯。其他脂肪醇包括乙醇、变性酒精(SDA40B和SDA3C)和异丙醇。
包含苯甲醇、植物制剂和1,3-丙二醇及其衍生物如2-甲基-1-硝基-1,3丙二醇(二醇)或2-羟甲基-2-硝基-1,3-丙二醇(三元醇)的组合的组合物还含有助溶剂,如甘油、辛氧基甘油、醇、二醇、丁二醇和苯氧乙醇。
在优选非限制性实施例中,溶剂为苯甲醇、甘油或它们的组合。
在某些实施例中,溶剂的使用浓度范围约为0.001%至90%(重量比)、或1%至85%(重量比)、或10%至70%(重量比)、或30%至65%(重量比)。在可选择实施例中,浓度范围约为5%至90%(重量比),优选约为30%至90%(重量比),更优选约为40%至80%(重量比)。在优选实施例中,溶剂为天然产物,例如来源于肉桂的苯甲醇。
在本发明的可选择性优选非限制性实施例中,溶剂为苯甲醇或其衍生物,例如羟基苯甲醇、硝基苯甲醇或其他衍生物。苯甲醇浓度范围在约为0.5%至10%(重量比)、优选约为0.5%至5%(重量比)、更优选约为0.5%至4%(重量比)时与某些植物有机酸尤其是果酸在一起具有抗微生物功效。可选择性实施例采用的苯甲醇浓度范围约为1.0%至5.0%(重量比)或约为1%至3%(重量比)。将在下文对使用其他植物性合成抗微生物剂与苯甲醇和这些果酸来进一步增强活性做详细说明。
4.7天然有机酸
根据本发明可使用例如果酸的天然有机酸,包括但不限于果酸、柠檬酸、乙醇酸、乳酸、苹果酸、酒石酸、苯甲酸、水杨酸和乙酸。在某些非限制性实施例中,果酸为复合水果酸(Multifruit BSC)(奥麒化工),为提取自植物的乳酸、柠檬酸、酒石酸和苹果酸的混合物。在优选非限制性实施例中,果酸为乳酸。本发明所使用的果酸可源自天然资源或者化工合成而得。
本文公开的组合物可使用的其他有机酸包括但不限于苯甲酸及其包括盐形式在内的衍生物,例如苯甲酸苄酯、对氨基苯甲酸盐、羟基苯甲酸、氟苯甲酸和水杨酸苄酯。
根据本发明可使用果酸协助银化合物的控制释放。果酸的非限制性实例包括但不限于柠檬酸、乙醇酸、乳酸、苹果酸、酒石酸和乙酸。在某些非限制性实施例中,果酸为复合水果酸(Multifont BSC)(奥麒化工),为提取自植物的乳酸、柠檬酸、酒石酸、乙醇酸和苹果酸的混合物。本发明组合物所使用的果酸可由其天然资源获得或者化工合成而得。在本发明优选非限制性实施例中,果酸为乳酸或柠檬酸。
在非限制性实施例中,果酸的浓度范围约为0%至70%(重量比)、或约为5%至70%(重量比)、或约为5%至20%(重量比)、或约为10%至20%(重量比)。在本发明可选择非限制性实施例中,浓度范围约为0%至20%(重量比)、或约为0%至40%(重量比)、或约为0.1%至20%(重量比)、或约为0.2%至4%(重量比)、或约为0.5%至4%(重量比)、或约为2%至4%(重量比)。
在可选择性实施例中,组合物中使用的天然有机酸浓度约为0.2%至2%(重量比)、或约为0.2%至1%(重量比)。在其他可选择性实施例中,组合物中使用的天然有机酸浓度约为0.01%至5%(重量比)、或约为0.01%至4%(重量比)、或约为0.01%至3%(重量比)、或约为0.01%至2%(重量比)、或约为0.01%至1%(重量比)、或约为0.02%至5%(重量比)、或约为0.02%至4%(重量比)、或约为0.02%至3%(重量比)、或约为0.02%至2%(重量比)、或约为0.02%至1%(重量比)、或约为0.05%至2.0%(重量比)、或约为0.1%至2.0%(重量比)。
4.8个人护理产品
在非限制性实施中,提供了个人护理产品组合物,其包含苯甲醇和一种或多种精油和/或一种或多种植物提取物,例如植物提取物或果实提取物。优选地,个人护理产品的pH值约为3.0至6.0。
使用本发明组合物的个人护理产品的非限制性实例包括块皂、液体皂(例如洗手液)、消毒洗手液(包括冲洗型或留存型醇基和水基手部消毒剂)、术前皮肤消毒剂、清洁巾、消毒巾、沐浴露、痤疮治疗产品、抗真菌护臀膏、抗真菌护肤膏、洗发剂、护发素、化妆品(包括但不限于液体或粉质粉底液、液体或固体眼线膏、睫毛膏、眼影膏、彩粉、干用或湿用粉饼等)、除臭剂、抗菌膏、身体护肤液、护手霜、局部乳膏、须后水、柔肤水、漱口水、牙膏、防晒液以及婴儿用品,例如但不限于清洁巾、婴儿洗发剂、婴儿皂和护臂霜。本发明还可应用于伤口护理产品,例如但不限于伤口愈合软膏、乳膏和搽液、创口贴、烧伤乳膏、绷带、胶带和伤口闭合带(steri-strips),以及医疗用品,例如医护防护服、帽、面罩和鞋套、手术幕布等。其他产品包括但不限于口腔用品,例如口腔清洗剂、牙膏、牙线涂料,动物及宠物护理产品、防腐剂组合物以及包括溶液、喷雾剂或擦巾在内的表面消毒剂。
本文所述的个人护理组合物还可包括选自由以下物质组成的集合中的一种或(优选)多种成分:润肤剂、稳定剂、增稠剂、保温剂、消炎剂、抗微生物剂、中和剂、表面活性剂、水、有机硅聚合物、醇和水凝胶,还包括其他本领域所述熟知的成分。这些成分的非限制性实例将在下文详细说明。
在不同非限制性实施例中,个人护理产品可包括润肤剂,例如PEG20杏仁甘油酯、Probutyl DB-10、Glucam P-20、Glucam E-10、Glucam P-10、Glucam E-20、Glucam P-20双硬脂酸酯、甘油、丙二醇、辛氧基甘油、醋酸十六烷酯、乙酰化羊毛脂醇(例如Acetulan)、十六烷基醚(例如PPG-10)、肉豆蔻醚(PPG-3)、羟化牛奶甘油酯(例如Cremeral HMG)、聚季铵盐化合物(例如U-care化合物)、聚二烯丙基二甲基氯化铵和丙烯酸的共聚物(例如Merquat)、二丙二醇甲醚(例如Dowanol DPM,Dow Corning)、聚丙烯乙二醇醚(例如Ucon50-HB-600,UnionCarbide)和硅聚合物。其他适宜的润肤剂可包括烃基润肤剂,例如凡士林或矿物油,脂肪酸酯基润肤剂,例如脂肪酸的甲酯、异丙酯和丁酯,例如棕榈酸异丙酯、肉豆蔻异丙酯、异硬脂酸异丙酯、异硬脂酸异硬脂醇脂、癸二酸二异丙酯,以及丙烯二壬酸酯、异壬酸-2-乙基己酯、2-乙基己酯(2-ethylhexyl stearate)、C12-C16脂肪酸乳酸酯(fatty alcohol lactate)如乳酸鲸蜡酯和月桂醇乳酸酯、羊毛酸异丙酯、水杨酸-2-乙基己酯、鲸蜡醇肉豆蔻酸酯、肉豆蔻酸油醇酯、硬脂酸油醇酯、油酸油醇酯、月桂酸己酯和月桂酸异己酯。其他有效的润肤剂包括羊毛脂、橄榄油、可可脂和牛油树脂。
在不同的非限制性实施例中,个人护理产品可包含一种稳定剂如抗氧化剂,例如但不限于维生素C(抗坏血酸)和/或维生素E(生育酚),以及/或者表面活性剂,例如但不限于incromide或基于硅氧烷的表面活性剂(Masil SF-19,BASF)。
在不同的非限制性实施例中,个人护理产品可包含增稠剂和/或胶凝剂,例如硬脂醇、阳离子羟乙基纤维素(Ucare;JR30)、羟丙基甲基纤维素、羟丙基纤维素(Klucel)、脱乙酰壳多糖吡咯烷酮羧酸盐(Kytamer)、山嵛醇、硬脂酸锌、乳化蜡,其包括但不限于Incroquat和Polawax,为另一种丙烯酸聚合物,树脂如 ETDTM2020、瓜尔胶、***树胶、丙烯酸脂/硬脂酸聚醚-20甲基丙烯酸酯共聚物、琼脂、褐藻胶、褐藻酸、丙烯酸铵共聚物、藻酸铵、氯化铵、硫酸铵、支链淀粉、硅镁土、膨润土、C9-C15醇、乙酸钙、藻酸钙、角叉菜钙、氯化钙、仲辛醇、卡波姆910、卡波姆934、卡波姆934P、卡波姆940、卡波姆941、羧甲基羟乙基纤维素、羧甲基羟丙基瓜尔胶、角叉菜、胶纤维素、纤维素羧甲醚、棕榈醇、鲸蜡醇、玉米淀粉、硬树胶、糊精、二联苯胺山梨糖醇、二(氢化牛脂酰)乙二胺、二油酰乙二胺、二硬脂酰乙二胺、明胶、瓜尔胶、瓜尔胶羟基丙基三甲基氯化胺、水辉石、透明质酸、水合硅石、羟丁基甲基纤维素、羟乙基纤维素、羟乙基乙基纤维素、羟乙基硬脂酰胺-MIPA、异鲸蜡醇、异硬脂醇、刺梧桐胶、大型褐藻、月桂醇、刺槐豆胶、硅酸铝镁、硅酸镁、三硅酸镁、甲氧基PEG-22/十二烷基甘醇共聚物、甲基纤维素、微晶纤维素、蒙脱土、肉豆蔻醇、燕麦粉、油醇、棕榈仁醇、胶质、PEG(聚乙二醇)-2M、PEG-5M、聚丙烯酸、聚乙烯醇、藻朊酸钾、聚丙烯酸铝钾、角叉菜钾、氯化钾、硫酸钾、马铃薯淀粉、丙二醇藻酸酯、丙烯酸钠/乙烯醇共聚物、羧甲基糊精钠、角叉菜胶钠、纤维素硫酸钠、氯化钠、聚甲基丙烯酸钠、硅铝酸钠、硫酸钠、司拉氯按膨润土、司拉氯铵水辉石、硬脂醇、牛脂醇、盐酸TEA盐、黄蓍胶、十三烷醇、氨丁三醇硅酸铝镁、小麦粉、小麦淀粉、黄原胶、枞醇、丙烯亚油酸(acrylinoleic acid)、山嵛酸铝、辛酸铝、二聚亚油酸铝、铝盐如硬脂酸盐、异硬脂酸铝、蜂蜡、山嵛酰胺、丁二烯/丙烯腈共聚物、C29-70酸、山嵛酸钙、硬脂酸钙、小烛树蜡、巴西棕榈、纯地蜡、胆甾醇、胆甾醇羟基硬脂酸酯、椰油醇、柯帕树脂、双甘油基硬脂酸酯苹果酸酯、二氢枞醇、二甲基月桂基胺油酸盐、十二双酸/十六/十八烷醇/乙二醇共聚物、芥酸酰胺、乙基纤维素、甘油三乙基羟基硬脂酸酯、甘油三乙基蓖麻醇酸酯、二山嵛酸乙二醇酯、二碘苯腈辛酸乙二醇酯、二硬脂酸乙二醇酯、二硬脂酸己二醇酯、氢化C6-C14链烯烃聚合物、氢化蓖麻油、氢化棉籽油、氢化猪脂、氢化鲱油、氢化棕榈仁甘油酯、氢化棕榈仁油、氢化棕榈油、氢化聚异丁烯、氢化大豆油、氢化牛油酰胺、氢化牛油甘油酯、氢化植物油甘油酯、氢化植物油、日本蜡、西蒙得木蜡、羊毛脂醇、牛油树脂、月桂酰胺、脱氢枞酸甲酯、氢化松脂酸甲酯、松脂酸甲酯、甲基苯乙烯/乙烯基甲苯共聚物、微晶蜡、褐煤酸蜡、褐煤蜡、十四烷基二十烷醇、十四烷基十八烷醇、十八烯/顺式丁烯二酸酐共聚物、辛基十二烷基硬脂酰胺硬脂酸盐、油酰胺、油硬脂、小冠巴西棕蜡、氧化聚乙烯、地蜡、石蜡、季戊四醇氢化松脂酸酯、季戊四醇四碘苯腈辛酸酯、季戊四醇松脂酸酯、季戊四醇四枞酸酯、季戊四醇四山嵛酸酯、季戊四醇四油酸酯、季戊四醇四硬脂酸酯、邻苯二甲酸酐/甘油/缩水甘油癸酸酯共聚物、邻苯二甲酸/偏苯三酸/乙二醇共聚物、聚丁烯、聚亚丁烯对苯二酸酯、聚双戊烯、聚乙烯、聚异丁烯、聚异戊二烯、聚乙烯醇缩丁醛、聚乙烯醇月桂酸酯、丙二醇二辛酸酯、丙二醇二椰油酸酯、丙二醇二异癸酸酯、丙二醇二月桂酸酯、丙二醇二壬酸酯、丙二醇二硬脂酸酯、丙二醇双十一烷酸酯、PVP/二十碳烯共聚物、PVP/十六碳烯共聚物、米糠蜡、司拉氯铵膨润土、司拉氯铵水辉石、硬脂酰胺、硬脂酰胺DEA-双硬脂酸酯、硬脂酰胺DIBA-硬脂酸酯、硬脂酰胺MEA-硬脂酸酯、硬脂酮、硬脂基芥酰胺、硬脂醇硬脂酸酯、硬脂醇硬脂酰氧基硬脂酸酯、合成蜂蜡、合成蜡、三羟基硬脂酸甘油酯、三异壬精、三异硬脂精、三异硬脂醇三聚亚油酸酯、三月桂精、三聚亚油酸、三亚油精、三肉豆蔻精、三油精、三棕榈精、月桂酸锌、新癸酸锌、松脂酸锌、以及它们的混合物。在产品中使用的胶凝剂可以是天然的胶凝剂,例如天然胶树胶、淀粉、胶质、琼脂和凝胶。通常情况下,胶凝剂以多糖或蛋白质为基础。实例包括但不限于瓜尔胶、黄原胶、褐藻酸(E400)、海藻酸钠(E401)、藻朊酸钾(E402)、藻酸铵(E403)烷二醇、还可包括保温剂,例如甘油、1-2-丙二醇、双丙甘醇、聚乙二醇、1,3-丁二醇或1,2,6-己三醇。
在某些非限制性实施中可包含一种或多种其他抗微生物剂,例如,这些抗微生物剂可选自由以下物质组成的集合:银盐、碘消灵、碘、苯甲酸、二氢乙酸、丙酸、山梨酸、羟苯甲酯、羟苯乙酯、羟苯丙酯、羟苯丁酯、溴棕三甲铵、杀藻胺、地喹氯铵、氯己定、氯甲酚、氯二甲酚、苯甲醇、溴硝丙二醇、三氯丁醇、苯氧乙醇、苯乙醇、2,4-二氯苯甲醇、硫柳汞、氯林可霉素、红霉素、过氧化苯甲酰、莫匹罗星、枯草杆菌素、多黏菌素B、新霉素、三氯生、对氯间二甲苯、膦甲酸、咪康唑、氟康唑、伊康唑、酮康唑、磺胺嘧啶银盐、辛氧基甘油(octoxyglycerine)、双胍,例如但不限于氯己定游离碱、棕榈酸氯己定、二氨基苯膦酸氯己定、二葡萄酸盐己定、二乙酸氯己定、二盐酸氯己定、二氯氯己定、二氢碘氯己定、二高氯酸氯己定、二硝酸氯己定、硫酸氯己定、硫代硫酸氯己定、二价磷酸氯己定(chlorhexidine di-acid phosphate)、二氟磷酸氯己定、二甲酸氯己定、二丙酸氯己定、二碘代丁酸氯己定、二正戊酸氯己定、二己酸氯己定、丙二酸氯己定、琥珀酸氯己定、苹果酸氯己定、酒石酸氯己定、二单乙醇酸氯己定、单二乙醇酸氯己定、乳酸氯己定、二-α-羟基异丁酸氯己定、二葡萄糖酸氯己定、二异硫代硫酸氯己定、二苯甲酸氯己定、二肉桂酸氯己定、二扁桃酸氯己定、二间苯二甲酸氯己定、二-2-羟基萘酸氯己定、双羟萘酸氯己定和盐酸聚六亚甲基胍(“PHMB”)。
在不同的非限制性实施例中,个人护理产品可包含中和剂以中和一种或多种其他成分中出现的羧基,例如增稠剂中的羧基。合适的中和剂包括二异丙胺和三乙醇胺。
在不同的非限制性实施例中,组合物可包含表面活性剂。所述表面活性剂可以是阴离子型表面活性剂、阳离子型表面活性剂、两性表面活性剂或非离子型表面活性剂。非离子型表面活性剂的实例包括聚乙氧基化物(polyethoxylate)、脂肪醇(例如鲸蜡醇聚醚-20(一种聚环氧乙烷的鲸蜡醚,具有平均约20个环氧乙烷单元)以及其他可从CI Americas,Inc.(美国特拉华州威尔明顿)购买的非离子型表面活性剂)、椰油酰胺丙基甜菜碱、烷基酚、山梨糖醇的脂肪酸酯、山梨聚糖、或聚氧乙烯山梨糖醇酐。非离子型表面活性剂的一个具体实例是215(Cognis),一种基于天然脂肪醇C8-C10的烷基糖苷。合适的阴离子型表面活性剂包括十二烷基硫酸铵和月桂醇磺基琥珀酸***(lauryl ethersulfosuccinate)。
在不同的非限制性实施例中,个人护理产品可包含水。
在不同的非限制性实施例中,个人护理产品中使用的组合物可包含水凝胶,其包含:例如一种化合物,如羟丙基甲基纤维素、阳离子羟乙基纤维素(U-care聚合物)、乙基纤维素、羟基丙基纤维素、羟甲基纤维素、羧甲基纤维素、聚环氧乙烷(聚氧树脂)以及壳聚糖吡咯烷酮羧酸酯(Kytomer PC)。
在不同的非限制性实施例中,个人护理产品可包含一种醇或多种醇的混合物,例如乙醇、异丙醇、正丙醇、以及它们的混合物;脂肪醇,包括但不限于鲸蜡醇、肉豆蔻醇、硬脂醇、辛醇、癸醇和月桂醇,以及它们的混合物;以及己醇。
在不同的非限制性实施例中,个人护理产品中使用的组合物可包含有机硅聚合物,例如一种或多种聚二甲基硅氧烷聚合物(Dow Corning225硅酮液)、二甲基硅油中的聚二甲基硅氧烷醇液体(Dow Corning1403桂酮液)、环聚二甲基硅氧烷和聚二甲基硅氧烷共聚物(Dow Coming3225C硅酮液)、以及硅酮二醇(BASF1066DCG多元醇)。
在不同的非限制性实施例中,个人护理产品中使用的组合物可包含一种润肤剂,如烷基链多达(含)18个碳分子的缩水甘油醚及其乙氧基化物和丙氧基化物、烷基链多达(含)18个碳分子的甘油醚及其乙氧基化物和丙氧基化物、烷基链多达(含)18个碳分子的单或二聚甘油醚及其乙氧基化物和丙氧基化物、乙氧基醚和丙氧基醚、乙氧基二甘醇酯、乙基己基丙氧基化物、丙二醇酯乙氧基化物和丙氧基化物、Arlamol(别名)。
在不同的非限制性实施例中,在个人护理产品中使用的组合物可包含一种或多种添加剂,例如染料;芳香剂;pH调节剂,包括碱性pH调节剂,如氨水、单-、二-和三烷基胺、单-、二-和三烷醇胺、碱金属和碱土金属氢氧化物(例如,氨水、氢氧化钠、氢氧化钾、氢氧化锂、单乙醇胺、三乙胺、异丙胺、二乙醇胺和三乙醇胺);酸性pH调节剂,例如矿物酸和多聚羧酸(例如,盐酸、硝酸、磷酸、硫酸、柠檬酸、乙醇酸和乳酸);维生素,例如维生素A、维生素E和维生素C;多聚氨基酸及其盐,例如乙二胺四乙酸(EDTA);防腐剂,例如Germall plus或DMDM乙内酰脲;以及防晒剂,例如氨基苯甲酸、阿伏苯宗(avobenzone)、西诺沙酯、二羟苯宗(dioxybenzone)、甲基水杨醇、薄荷醇邻氨基苯甲酯、奥克立林、甲氧肉桂酸辛酯、水杨酸辛酯、含氧安息香酸盐、二甲胺基苯甲酸戊酯O、苯基苯并咪唑、磺酸、舒利苯酮、二氧化钛、三乙醇胺水杨酸盐和氧化锌。
在一组非限制性实施例中,个人护理组合物即具有抗微生物活性又具有抗炎(AM-AI)活性,而且,例如,还可用作皮肤清洁剂或局部用软膏。
本发明还提供了快速起效的AMI手部消毒液。GSE、苯甲醇和1,3-丙二醇组合与抗炎剂CRMN、可食用植物提取物和石榴籽油(PSO)一起使用时抗微生物活性增强。
本发明还对快速起效的植物性AM-AI手部消毒液提出了设想。
在具体的非限制性实施例中,本发明提供了用于小伤口或创面的包含抗刺激剂、抗炎剂、胶凝剂和植物制剂的局部用乳膏配方的制备。
可通用使用醇类如苯甲醇、果酸、可选择使用的双胍以及杀藻胺组合使抗真菌剂的抗真菌活性明显增强。
本发明还提供了包含GSE、苯甲醇、THC和基于椰子的磷脂的配方,用于醇基消毒洗手液(AHS)组合物。
本发明还提供了不含醇的植物性手部消毒液,其包含约0.5%至2%(重量比)苯甲醇;约0.3%至2%(重量比)硅酮液;约0.1%至0.5%(重量比)氧化锌;约0.1%至2%(重量比)果酸,例如乳酸或柠檬酸;约0.05%至1%(重量比)的选自芦荟胶、GSE、柑橘提取物、山葵提取物、柳树皮提取物、山杨提取物和金银花提取物中的一种或多种植物制剂;以及约0.1%至0.5%(重量比)的选自牛至油、石榴油、迷迭香油、香茅草油和肉桂油(例如,肉桂叶油或桂皮油)中的一种或多种精油。这些组合物可选择性地包含约0.5%至2%(重量比)法尼醇、约0.05%至0.3%(重量比)百里香酚和/或约0.2%至1%(重量比)烷二醇。
以下将详细说明不含醇的植物性手部消毒液配方的非限制性实例。
不含醇的植物性手部消毒液A
调节pH值至5.5-6.0
本发明不含醇的植物性手部消毒液配方的具体非限制性实例包括以下配方。
不含醇的植物性手部消毒液A
调节pH值至5.5-6.0
本发明不含醇的植物性手部消毒液配方的非限制性普通实例包括以下配方。
不含醇的植物性手部消毒液B
调节pH值至5.5-6.0。
本发明不含醇的植物性手部消毒液配方的具体非限制性实例包括以下配方。
不含醇的植物性手部消毒液B
调节pH值至5.5-6.0。
本发明不含醇的植物性手部消毒液配方的非限制性普通实例包括以下配方。
不含醇的植物性手部消毒液
调节pH值至5.5-6.0。
本发明不含醇的植物性手部消毒液配方的具体非限制性实例包括以下配方。
不含醇的植物性手部消毒液
调节pH值至5.5-6.0。
本发明还提供了含有苯甲醇和植物制剂的水性植物性手部消毒液。以下为该配方的非限制性普通实例。
水性植物性手部消毒液A
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的具体非限制性实例包括以下配方。
水性植物性手部消毒液A
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性普通实例包括以下配方。
水性植物性手部消毒液B
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性具体实例包括以下配方。
水性植物性手部消毒液B
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性普通实例包括以下配方。
水性植物性手部消毒液1
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性具体实例包括以下配方。
水性植物性手部消毒液1
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性普通实例包括以下配方。
水性植物性手部消毒液2
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性具体实例包括以下配方。
水性植物性手部消毒液2
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性普通实例包括以下配方。
水性植物性手部消毒液3
调节pH值至5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒液的非限制性具体实例包括以下配方。
水性植物性手部消毒液3
调节pH值至5.5-6.0。
本发明还提供了含有苯甲醇和植物制剂的水性植物性手部消毒泡沫。以下为该配方的非限制性普通实例。
水性植物性手部消毒泡沫A
调节pH值为4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性具体实例包括以下配方。
水性植物性手部消毒泡沫A
调节pH值至4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性普通实例包括以下配方。
水性植物性手部消毒泡沫B
调节pH值至4.0-4.5
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性具体实例包括以下配方。
水性植物性手部消毒泡沫B
调节pH值至4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性普通实例包括以下配方。
水性植物性手部消毒泡沫1
调节pH值至4.0-4.5或5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性具体实例包括以下配方。
水性植物性手部消毒泡沫1
调节pH值至4.0-4.5或5.5-6.0。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性普通实例包括以下配方。
水性植物性手部消毒泡沫A1
调节pH值至4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性具体实例包括以下配方。
水性植物性手部消毒泡沫A1
调节pH值至4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性普通实例包括以下配方。
水性植物性手部消毒泡沫2
调节pH值至4.0-4.5。
本发明含有苯甲醇和植物制剂的水性植物性手部消毒泡沫的非限制性具体实例包括以下配方。
水性植物性手部消毒泡沫2
调节pH值至4.0-4.5。
本发明还提供了含有苯甲醇和植物制剂的天然醇泡沫手部消毒剂。以下是该配方的非限制性实例。
天然醇泡沫手部消毒剂
本发明含有苯甲醇和植物制剂的天然醇泡沫手部消毒剂的非限制性具体实例包括以下配方。
天然醇泡沫手部消毒剂
本发明含有苯甲醇和植物制剂的天然醇泡沫手部消毒剂的非限制性普通实例包括以下配方。
天然醇泡沫手部消毒剂1
本发明含有苯甲醇和植物制剂的天然醇泡沫手部消毒剂的非限制性具体实例包括以下配方。
天然醇泡沫手部消毒剂1
本发明还提供了含有苯甲醇和植物制剂的天然醇手术用手部消毒剂。以下是该配方的非限制性普通实例。
天然醇手术用手部消毒剂
本发明含有苯甲醇和植物制剂的天然醇手术用手部消毒剂的非限制性具体实例包括以下配方。
天然醇手术用手部消毒剂
本发明还提供了含有苯甲醇和植物制剂的植物性消毒皂。以下是该配方的非限制性普通实例。
植物性消毒皂A
本发明含有苯甲醇和植物制剂的植物性消毒皂的非限制性具体实例包括以下配方。
植物性消毒皂A
本发明含有苯甲醇和植物制剂的植物性消毒皂的非限制性普通实例包括以下配方。
植物性消毒皂B
本发明含有苯甲醇和植物制剂的植物性消毒皂的非限制性具体实例包括以下配方。
植物性消毒皂B
本发明含有苯甲醇和植物制剂的植物性消毒皂的非限制性普通实例包括以下配方。
植物性消毒皂
本发明含有苯甲醇和植物制剂的植物性消毒皂的非限制性具体实例包括以下配方。
植物性消毒皂
在某些实施例中提供了一种抗真菌抗痒组合物,其包含约0.5%(重量比)至5%(重量比)苯甲醇和一种或多种化合物,所述化合物选自由以下物质组成的集合:
(a)约0.04%(重量比)至0.5%(重量比)植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、金银花提取物、雪松木提取物、山杨树皮提取物、柳树皮提取物、布拉米(Brahmi)提取物、以及它们的组合;
(b)约0.04%(重量比)至1.05%(重量比)精油,所述精油选自由以下物质组成的集合:香茅草油、肉桂油、牛至油、百里香酚、高良姜油、橙油、石榴油、金盏花油、咖喱叶油或它们的组合;以及
(c)约0.2%(重量比)至2.0%(重量比)天然有机酸。
在某些非限制性实施例中提供了以下抗真菌抗痒组合物:
在本申请含有苯甲醇和植物制剂的不含醇的植物性手部消毒液的非限制性实例中,首先分别制备A相溶液和B相溶液,然后混合,包括以下配方。
不含醇的植物性手部消毒液
在本申请含有苯甲醇和植物制剂的不含醇的植物性手部消毒液的非限制性具体实例中,首先分别制备A相溶液和B相溶液,然后混合,包括以下配方。
不含醇的植物性手部消毒液
本申请的不含醇的植物性手部消毒泡沫的非限制性普通实例包括以下配方。
不含醇的植物性手部消毒泡沫
调节pH值至4.0-4.5。
本申请不含醇的植物性手部消毒泡沫的非限制性具体实例包括以下配方。
不含醇的植物性手部消毒泡沫
调节pH值至4.0-4.5。
4.14伤口愈合
本发明组合物可用于促进伤口愈合以及/或者防止表面感染。在不同的非限制性实施例中,本发明组合物可使用于例如局部用乳膏和洗液、伤口护理产品、烧伤创面乳膏、褥疮乳膏(具有抗炎植物制剂并使用磺胺嘧啶银盐作为抗微生物剂)以及治疗用软膏中。本发明组合物还可应用于伤口护理产品,例如但不限于伤口愈合软膏、创口贴、烧伤乳膏、绷带、胶带和伤口闭合带,以及应用于医疗用品,例如医护防护服、帽、面罩和鞋套,手术幕布等。
在不同的非限制性实施例中,组合物可包含增稠剂和/或胶凝剂,例如硬脂醇、阳离子羟乙基纤维素(Ucare;JR30)、羟丙基甲基纤维素、羟丙基纤维素(Klucel)、脱乙酰壳多糖吡咯烷酮羧酸盐(Kytamer)、山嵛醇、硬脂酸锌、乳化蜡,其包括但不限于Incroquat和Polawax,为另一种丙烯酸聚合物,树脂如 ETDTM2020、瓜尔胶、***树胶、丙烯酸脂/硬脂酸聚醚-20甲基丙烯酸酯共聚物、琼脂、褐藻胶、褐藻酸、丙烯酸铵共聚物、藻酸铵、氯化铵、硫酸铵、支链淀粉、硅镁土、膨润土、C9-C15醇、乙酸钙、藻酸钙、角叉菜钙、氯化钙、仲辛醇、卡波姆910、卡波姆934、卡波姆934P、卡波姆940、卡波姆941、羧甲基羟乙基纤维素、羧甲基羟丙基瓜尔胶、角叉菜、胶纤维素、纤维素羧甲醚、棕榈醇、鲸蜡醇、玉米淀粉、硬树胶、糊精、二联苯胺山梨糖醇、二(氢化牛脂酰)乙二胺、二油酰乙二胺、二硬脂酰乙二胺、明胶、瓜尔胶、瓜尔胶羟基丙基三甲基氯化胺、水辉石、透明质酸、水合硅石、羟丁基甲基纤维素、羟乙基纤维素、羟乙基乙基纤维素、羟乙基硬脂酰胺-MIPA、异鲸蜡醇、异硬脂醇、刺梧桐胶、大型褐藻、月桂醇、刺槐豆胶、硅酸铝镁、硅酸镁、三硅酸镁、甲氧基PEG-22/十二烷基甘醇共聚物、甲基纤维素、微晶纤维素、蒙脱土、肉豆蔻醇、燕麦粉、油醇、棕榈仁醇、胶质、PEG(聚乙二醇)-2M、PEG-5M、聚丙烯酸、聚乙烯醇、藻朊酸钾、聚丙烯酸铝钾、角叉菜钾、氯化钾、硫酸钾、马铃薯淀粉、丙二醇藻酸酯、丙烯酸钠/乙烯醇共聚物、羧甲基糊精钠、角叉菜胶钠、纤维素硫酸钠、氯化钠、聚甲基丙烯酸钠、硅铝酸钠、硫酸钠、司拉氯按膨润土、司拉氯铵水辉石、硬脂醇、牛脂醇、盐酸TEA盐、黄蓍胶、十三烷醇、氨丁三醇硅酸铝镁、小麦粉、小麦淀粉、黄原胶、枞醇、丙烯亚油酸(acrylinoleic acid)、山嵛酸铝、辛酸铝、二聚亚油酸铝、铝盐如硬脂酸盐、异硬脂酸铝、蜂蜡、山嵛酰胺、丁二烯/丙烯腈共聚物、C29-70酸、山嵛酸钙、硬脂酸钙、小烛树蜡、巴西棕榈、纯地蜡、胆甾醇、胆甾醇羟基硬脂酸酯、椰油醇、柯帕树脂、双甘油基硬脂酸酯苹果酸酯、二氢枞醇、二甲基月桂基胺油酸盐、十二双酸/十六/十八烷醇/乙二醇共聚物、芥酸酰胺、乙基纤维素、甘油三乙基羟基硬脂酸酯、甘油三乙基蓖麻醇酸酯、二山嵛酸乙二醇酯、二碘苯腈辛酸乙二醇酯、二硬脂酸乙二醇酯、二硬脂酸己二醇酯、氢化C6-C14链烯烃聚合物、氢化蓖麻油、氢化棉籽油、氢化猪脂、氢化鲱油、氢化棕榈仁甘油酯、氢化棕榈仁油、氢化棕榈油、氢化聚异丁烯、氢化大豆油、氢化牛油酰胺、氢化牛油甘油酯、氢化植物油甘油酯、氢化植物油、日本蜡、西蒙得木蜡、羊毛脂醇、牛油树脂、月桂酰胺、脱氢枞酸甲酯、氢化松脂酸甲酯、松脂酸甲酯、甲基苯乙烯/乙烯基甲苯共聚物、微晶蜡、褐煤酸蜡、褐煤蜡、十四烷基二十烷醇、十四烷基十八烷醇、十八烯/顺式丁烯二酸酐共聚物、辛基十二烷基硬脂酰胺硬脂酸盐、油酰胺、油硬脂、小冠巴西棕蜡、氧化聚乙烯、地蜡、石蜡、季戊四醇氢化松脂酸酯、季戊四醇四碘苯腈辛酸酯、季戊四醇松脂酸酯、季戊四醇四枞酸酯、季戊四醇四山嵛酸酯、季戊四醇四油酸酯、季戊四醇四硬脂酸酯、邻苯二甲酸酐/甘油/缩水甘油癸酸酯共聚物、邻苯二甲酸/偏苯三酸/乙二醇共聚物、聚丁烯、聚亚丁烯对苯二酸酯、聚双戊烯、聚乙烯、聚异丁烯、聚异戊二烯、聚乙烯醇缩丁醛、聚乙烯醇月桂酸酯、丙二醇二辛酸酯、丙二醇二椰油酸酯、丙二醇二异癸酸酯、丙二醇二月桂酸酯、丙二醇二壬酸酯、丙二醇二硬脂酸酯、丙二醇双十一烷酸酯、PVP/二十碳烯共聚物、PVP/十六碳烯共聚物、米糠蜡、司拉氯铵膨润土、司拉氯铵水辉石、硬脂酰胺、硬脂酰胺DEA-双硬脂酸酯、硬脂酰胺DIBA-硬脂酸酯、硬脂酰胺MEA-硬脂酸酯、硬脂酮、硬脂基芥酰胺、硬脂醇硬脂酸酯、硬脂醇硬脂酰氧基硬脂酸酯、合成蜂蜡、合成蜡、三羟基硬脂酸甘油酯、三异壬精、三异硬脂精、三异硬脂醇三聚亚油酸酯、三月桂精、三聚亚油酸、三亚油精、三肉豆蔻精、三油精、三棕榈精、月桂酸锌、新癸酸锌、松脂酸锌、以及它们的混合物。在产品中使用的胶凝剂可以是天然的胶凝剂,例如天然胶树胶、淀粉、胶质、琼脂和凝胶。通常情况下,胶凝剂以多糖或蛋白质为基础。实例包括但不限于瓜尔胶、黄原胶、褐藻酸(E400)、海藻酸钠(E401)、藻朊酸钾(E402)、藻酸铵(E403)、藻酸钙(E404,-源自褐海藻的多糖)、琼脂(E406,源自红色海藻的多糖)、角叉菜胶(E407,从红色海藻获得的多为糖)、刺槐豆胶(E410,来源于角豆树种籽的天然树胶)、胶质(E440,由苹果或柑橘类水果获得的多糖)以及凝胶(E441,由动物胶原蛋白部分水解制成)。
不同实施例可包含稳定剂。在一个非限制性实施例中,将过硼酸钠用作稳定剂,用量范围约为0.3%至1%(重量比)。
本申请的不同实施例还可包含表面活性剂。所述表面活性剂可以是阴离子型表面活性剂、阳离子表面活性剂、两性表面活性剂或非离子型表面活性剂。非离子型表面活性剂的实例包括聚乙氧基化物(polyethoxylate)、脂肪醇(例如鲸蜡醇聚醚-20(一种聚环氧乙烷的鲸蜡醚,具有平均约20个环氧乙烷单元)以及其他可从CI Americas,Inc.(美国特拉华州威尔明顿)购买的非离子型表面活性剂)、椰油酰胺丙基甜菜碱、烷基酚、山梨糖醇的脂肪酸酯、山梨聚糖、或聚氧乙烯山梨糖醇酐。合适的阴离子型表面活性剂包括十二烷基硫酸铵和月桂醇磺基琥珀酸***(lauryl ether sulfosuccinate)。优选表面活性剂包括月桂酰乙二胺三乙酸钠盐,Pluronic F87,Masil SF-19(BASF)和incromide。
本文所述配方中使用的水优选pH中性的去离子水。
在具体的非限制性实施例中,本发明提供了伤口愈合局部用乳膏,其包含磺胺嘧啶银、一种不溶锌盐、一种可溶锌盐和金盏花油。在另一个非限制性实施例中,本发明提供了伤口愈合局部用乳膏,其包含磺胺嘧啶银、一种不溶锌盐、一种可溶锌盐、金盏花油以及抗炎剂如姜黄素化合物。
乳膏产品的非限制性实例还可包含白矿脂(2-20%)脂肪醇(2-20%)、润肤剂(1-10%)、乳化剂(0.5-10%)、保湿剂(2-15%)、防腐剂(0.1-0.5%)以及适量去离子水或蒸馏水100%。脂肪醇包括硬脂醇、鲸蜡醇、月桂醇、肉豆蔻醇以及其他已知的醇。润肤剂包括肉豆蔻酸异丙酯、羊毛脂、羊毛脂衍生物、棕榈酸异丙酯、鸸鹋油、亚麻籽油和其他已知的润肤剂。乳化剂包括单油酸钠和聚氧乙烯(40)硬脂酸酯。保湿剂包括丙二醇、山梨醇、或甘油、或者它们的混合物。合适的水溶性防腐剂包括羟基苯类(paraben)、山梨酸、苯甲酸、双(羟甲基)咪唑烷基脲和碘丙炔醇丁基氨甲酸酯(Germal+)。
本发明提供了包含苯甲醇和植物制剂的植物性伤口愈合凝胶配方。以下是该配方的非限制性普通实例。
植物性伤口愈合凝胶
调节pH值至5.0-6.0。
本申请的含有苯甲醇和植物制剂的植物性伤口愈合凝胶的非限制性具体实例包括以下配方。
植物性伤口愈合凝胶
调节pH值至5.0-6.0。
4.15兽用产品
在一部分非限制性实施例中,本发明提供了用于护理家畜的兽用产品,包括但不限于猫、狗、鸟、啮齿目动物、马、奶牛和牛、绵羊、山羊等。
使用本发明组合物的兽用护理产品的非限制性实例包括宠物洗发剂、宠物清洁巾,其中包括身体擦巾、耳朵擦巾和眼睛擦巾,以及牙齿擦巾、牙膏、耳朵清洁液、笼子去污剂、表面清洁剂、室内便溺清洁剂、局部用乳膏、软膏、用于乳腺炎的***浸液以及涂抹于宠物皮肤上的液体(如同“身体保湿喷雾”)。
根据本申请的兽用护理组合物还可包含一种或多种(优选)成分,所述成分选自由以下物质组成的集合:润肤剂、稳定剂、增稠剂、保温剂、抗微生物剂、中和剂、表面活性剂、水、硅酮聚合物、醇、以及水凝胶、消炎剂、伤口愈合剂、水杨酸,还有其他本领域所熟知的成分。
宠物护理产品所包含的其他成分的具体非限制性实例包括上述个人护理产品列出的成分。
在本申请的某些非限制性实施例中,组合物可以是用于治疗乳腺炎的***浸液。***浸液所使用的抗刺激剂可包括但不限于具于泛酰醇的锌盐、具有姜根提取物(馨敏舒)的没药醇、或具有锌盐的馨敏舒。在产品中使用的凝胶剂可包括但不限于天然凝胶剂,例如天然树胶、淀粉、胶质、琼脂和凝胶。抗微生物剂可包括但不限于香茅草油、橙油和果酸例如柠檬酸和乳酸、苯氧乙醇(鼠尾草油的组成成分)。
4.16家庭/工业产品
在一部分非限制性实施例中,本发明提供了包含前述配方的家庭/工业产品。
可使用本发明组合物的家庭/工业产品的非限制性实施例包括家用清洁剂,例如浓缩液清洁剂和喷雾清洁剂、清洁擦巾、餐具清洗液、洗碗机洗涤剂、喷雾式地板液、家具上光剂、室内漆、室外漆、除尘喷雾剂、洗衣液、织物柔顺剂、地毯织物清洁剂、窗户及玻璃清洁剂、马桶清洁剂、液体/乳膏清洁剂等。在特别实施例中,本发明组合物可使用于食品清洗产品,用于在食用前清洁水果和蔬菜。“家庭产品”是除个人护理产品外由个人消费者使用的产品。“工业产品”是指在工业中使用的产品。
根据本申请的家庭/工业组合物可包含一种或多种成分,所述成分选自由以下物质组成的集合:表面活性剂、促净剂(例如螯合促净剂、沉淀促净剂、离子交换促净剂)、溶剂、增稠剂、磨蚀剂、酸、碱(碱金属)、抗微生物剂、肥皂、漂白剂、酶、防腐剂和起泡剂,以及其他本领域熟知的成分。
在不同的非限制性实施中,组合物可包含表面活性剂(例如但不限于阴离子表面活性剂,如烷基硫酸酯)、烷基二苯醚二磺酸盐(例如由Dow Chemical Company生产的DOWFAX系列)、烷基苯磺酸盐、醇乙氧基硫酸酯、非离子型表面活性剂例如仲醇乙氧基化物(如由Dow Chemical Company生产的TERGITAOL系列)或烷基聚葡萄糖苷(如由Dow Chemical Company生产的TRITON系列);或者两性表面活性剂例如咪唑啉或甜菜碱化合物。
在不同的非限制性实施例中,组合物可包含溶剂,例如但不限于水、醇例如甲醇、乙醇、异丙醇或丁醇、碳氢化合物例如芳烃、丙二醇二氯甲烷丙酮、石油馏出物、及/或乙二醇醚。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含增稠剂,例如但不限于聚乙二醇、甲氧基聚乙二醇、及/或羟乙基纤维素。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含磨蚀剂,例如但不限于二氧化硅、长石或方解石。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含酸,例如但不限于乙酸、羟基乙酸、磷酸或盐酸。在不同的非限制性实施例中,在家庭/工业中使用的组合物可包含碱(碱金属),例如但不限于氨水或碳酸氢钠。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含抗微生物剂,例如但不限于前文所述的个人护理组合物中的化合物,以及松树油和次氯酸钠。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含漂白剂、例如但不限于次氯酸钠、过氧化氢、过碳酸钠和过硼酸钠。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含酶,例如但不限于蛋白酶或脂肪酶。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含防腐剂,例如但不限于二丁基羟基甲苯、戊二醛和EDTA。
在不同的非限制性实施例中,在家庭/工业产品中使用的组合物可包含起泡剂,例如但不限于乙醇胺或三乙醇胺。
在具体的非限制性实施例中,本发明提供了以下表面清洁剂,包含这些配方的活性成分浓缩液及浓缩原液,可分别对浓缩液和浓缩原液进行稀释得到所需浓度。
在一部分非限制性实施例中,本发明提供了含有前述配方的防腐剂和表面消毒剂。
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下普通配方。
植物性防腐剂A
用量为0.20%至1.0%。
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下具体配方。
植物性防腐剂A
用量为0.20%至1.0%。
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下普通配方。
植物性表面消毒剂A
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下具体配方。
植物性表面消毒剂A
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下普通体配方。
植物性表面消毒剂B
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下具体配方。
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下普通配方。
硬表面消毒剂C
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下具体配方。
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下普通配方。
植物性表面消毒剂LG-50
在非限制性实施例中,本发明的防腐剂和表面消毒剂包括以下具体配方。
植物性表面消毒剂LG-50
植物性消毒喷雾剂
4.17医疗设备
在一部分非限制性实施例中,本发明提供了包含前述配方的医疗设备。
医疗设备的***在***部位产生急性炎症反应。这可导致在医疗设备表面形成生物膜。医疗设备表面上的生物膜成为微生物的受体,产生微生物附着。防止***的医疗设备周围发生炎症可防止微生物附着在该设备上。通过涂抹并/或浸渗抗炎剂和抗微生物剂来保持设备周围环境无炎症和感染发生,以此达到上述目的。
抗炎抗微生物组合物包含苯甲醇、1,3-丙二醇和THC组合(具有或不具有其他抗微生物剂,例如氯己定和银盐),可涂抹或浸渗于医疗设备,如导尿管、创伤敷料、软组织补片等。
4.18杀虫剂
在一部分非限制性实施例中,本发明提供了包含前述配方的杀虫剂。在一个非限制性普通实例中,本发明杀虫剂包括以下配方。
植物性植物杀虫剂
使用时,上述组合物可用例如水溶解至1至10。
在非限制性具体实例中,本发明杀虫剂包括以下配方。
植物性植物杀虫剂
使用时,上述组合物可用例如水溶解至1至10。
5.实例
本文以引用的方式结合以下本申请的实际例子进行详细说明。
实际例子有时是指肥皂。肥皂是一种市售的液体皂,抗菌洗手皂包含活化剂,0.15%三氯生,非活性剂为水、月桂醇聚醚硫酸酯钠、癸基葡糖苷、椰油酰胺丙基甜菜碱、甘油、氯化钠、PEG-18甘油油酸酯/椰油酸酯、香精、椰油酰胺MEA、DMDM乙内酰脲、乙二胺四乙酸四钠和染料。
实例1
水性植物性手部消毒泡沫A的抗微生物功效:快速(15秒)和广谱抗菌功效
使用FDA TFM方法*(使用少量杀菌消毒剂并进行微生物培养进行轻微改动,但份额比例相同)测试快速杀灭细菌功效。对本发明手部消毒泡沫对表1列出的各种有机物的快速抗菌活性(15秒暴露)进行测试。所测试的手部消毒泡沫包含以下配方。
水性植物性手部消毒泡沫A
调节pH值为4.0-4.5。
方法
简单地说,将手部消毒泡沫(0.8毫升)放入无菌培养管中,加入0.2毫升用1:1成牛血清稀释的109cfu/ml测试细菌培养物(或107cfu/ml Candida培养物)并混合。15秒后,用药物中和液(DNF)中止抗微生物活性。用DNF连续稀释,等份数在胰酶大豆琼脂上进行再次培养以测定每份样本的微生物菌落数量。作为对照,使用含有相同细菌培养物的磷酸盐缓冲盐水(PBS)取代测试配方。通过测定对照组(磷酸盐缓冲盐水)与测试样本之间的log10菌落形成单元(cfu)的差(即log10减少)来计算抗菌活性。进行3次实验,每次实验每组包含三个样本。对含有三氯生和PCMX的肥皂和含醇(62%)手部消毒剂进行类似的测试以进行比较。
表1:通过FDA TFM方法*得到的水性植物性手部消毒泡沫和Purell的快速广谱抗微生物功效结果
ND=未检
*FDA TFM=暂定最终专论;ATCC=美国模式菌种收集中心;MRSA=耐甲氧西林金黄色葡萄球菌;VREF=抗万古霉素肠球菌。
对照组繁殖生长范围是5×108至1×109cfu/ml。结果是每组十二个样本的平均值。
实例2
水性植物性手部消毒泡沫A的快速持久抗菌功效
使用猪皮测试法来检验水性植物性手部消毒剂的抗微生物功效。猪皮测试模拟美国材料与测试协会(ASTM)E-1174(检定菌:金黄色葡萄球菌)的志愿者方法。所测试的手部消毒泡沫包含以下配方。
水性植物性手部消毒泡沫A
调节pH值为4.0-4.5。
方法
制备3cm2的猪皮,将每块猪皮固定到培养皿上。为了确定基准数,将2块猪皮样本用自来水冲洗30秒,然后用0.5毫升非抗菌皂泡沫摩擦这两块猪皮30秒。然后将这两块猪皮用自来水冲洗30秒去除污渍。每块猪皮用15微升107cfu/ml金黄色葡萄球菌培养液玷染,相互摩擦30秒,干燥30秒。用10毫升DNF冲洗每块猪皮15秒来回收猪皮上的有机物,收集洗液。将连续稀释液的等分量均匀分布在TSA平板上,在37℃培养24-48小时。为了计算测试样本的功效,将用于确定基准数的相同的猪皮块用自来水冲洗,然后用非抗菌皂冲洗,再次玷染。干燥30秒后,将0.5毫升测试消毒剂施用于猪皮上并用肥皂泡擦洗30秒。冲洗以后,用上述方法回收细菌。再进行9次玷染与消毒剂施用。确定第1次施用后和第10次施用后的菌落计数,计算基准样本与测试样本之间的菌落形成单元(cfu)的log10差值(log10减少)。手部消毒泡沫的抗微生物活性如表2所示。
表2:通过猪皮法反复施用后手部消毒泡沫A的快速持久抗菌功效(检定菌:金黄色葡萄球菌(ATCC6538))。
结论:根据US FDA-TFM标准,对于快速抗微生物活性,要求第1次施用后与对照组计数相比log10减少2.0log,对于持久抗微生物活性,要求第10次施用后减少3.0log。与含醇消毒剂Purell不同,本发明水性植物性手部消毒泡沫达到了US FDA-TFM的log减少标准。
实例3
表面消毒剂的抗微生物功效评价:体外快速杀灭(15秒)金黄色葡萄球菌
方法
将表面活性剂(0.8ml)放入无菌培养管中,加入0.2毫升用1:1成年牛血清稀释的109cfu/ml测试菌培养物并混合。15秒后,用药物中和剂(DNF)中止抗微生物活性。用DNF连续稀释,等份数在胰酶大豆琼脂上进行再次培养以测定每份样本的微生物菌落数量。作为对照,使用含有相同细菌培养物的磷酸盐缓冲盐水(PBS)取代测试配方。通过测定对照组(磷酸盐缓冲盐水)与测试样本之间的log10的差(即log10减少)来计算抗菌活性。所测试的表面消毒剂包括以下配方。
植物性表面消毒剂LG-50
表3
*其含有长链季铵化合物
对照组细菌计数:8.5-9.9log10
Proquart的稀释按照产品标签上的指示进行:Proquart0.17%季铵化合物(1盎司和2盎司)稀释到1加仑。
结论:植物性表面消毒剂的抗微生物功效强于Proquart。
实例4
暴露于本发明组合物10分钟后,消毒剂对于瓷砖上干燥细菌的功效
方法
在本实验中将金黄色葡萄球菌、MRSA和大肠杆菌作为测试有机物。首先,用水将尺寸为5×15cm2的瓷砖清洗干净,然后用70%乙醇清洗,干燥。用无菌玻璃棒将每份大约0.1毫升的1×107cfu/ml微生物均匀分布于瓷砖上,干燥1小时。将0.3毫升本发明表面清洁剂散布到瓷砖上,室温干燥10分钟。用9.7毫升药物中和液(DNF)冲洗瓷砖表面入无菌培养皿中以回收残留在瓷砖上的微生物。将回收介质连续稀释,平铺在TSA平板上,在37℃孵育18-24小时,然后确定菌落数量。作为对照,进行相同的步骤,只是用0.3毫升磷酸盐缓冲盐水代替表面清洁剂。Proquart是Clorox公司生产的含有季胺化合物(10.85%季胺化合物)的消毒剂,同时对其进行测试作为比较。所测试的表面消毒剂包含以下配方。
植物性表面消毒剂LG-50
表面消毒剂的抗微生物活性如表4所示。
表4
施用LG-50表面消毒剂10分钟对瓷砖上干燥细菌的功效
对照组繁殖生长范围为5×105-1×106。
Proquart的稀释按照产品标签上的指示进行:Proquart0.17%季铵化合物(1盎司和2盎司)稀释到1加仑。
含有0.12%精油(1盎司)的LG50稀释到5盎司。
结论:该植物性表面消毒剂的抗微生物功效强于Proquart。
本文引用了各种专利和非专利出版物,其全部内容通过引用并入本文。
Claims (17)
1.一种抗微生物组合物,包含:
(a)约0.5%重量比至50%重量比的苯甲醇;
(b)约0.01%重量比至5%重量比的精油;
(c)约0.5%重量比至10%重量比的植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、金银花提取物、雪松木提取物、山杨树皮提取物、柳树皮提取物、烟草提取物、以及它们的组合。
2.一种抗微生物组合物,包含:
(a)约0.5%重量比至50%重量比的苯甲醇;
(b)约0.01%重量比至5%重量比的精油;
(c)约0.5%重量比至10%重量比的植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、葡萄柚籽提取物、金银花提取物、雪松森提取物、石榴提取物、紫松果菊提取物、山杨树皮提取物、柳树皮提取物、以及它们的组合。
3.一种抗微生物组合物,包含:
(a)约0.5%重量比至2.0%重量比的苯甲醇;
(b)约0.5%重量比至4.0%重量比的特殊阳离子复合物;
(c)约0.2%重量比至0.5%重量比的苯甲酸;
(d)约0.05%重量比至1%重量比的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油、高良姜油、石榴油和香茅草油;以及
(e)0.2%重量比至2.0%重量比的一种或多种植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、布拉米提取物、白藜芦醇芦荟凝胶和芦荟叶汁。
4.根据权利要求3所述的组合物,还包含0.1%重量比至0.5%重量比的氧化锌。
5.根据权利要求3所述的组合物,还包含0.2%重量比至0.5%重量比的苯甲酸钠。
6.根据权利要求3所述的组合物,还包含约0.1%重量比至1.0%重量比的戊二醇。
7.一种抗微生物组合物,包含:
(a)约0.1%重量比至2.0%重量比的苯甲醇;
(b)约0.1%重量比至2.0%重量比的苯甲酸;
(c)约0.5%重量比至1.0%重量比的苯氧乙醇;
(d)约0.3%重量比至1.3%重量比的倍半萜,其形式为单一倍半萜或倍半萜类混合物;
(e)约0.05%重量比至2.5%重量比的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油、高良姜油、石榴油和香茅草油;以及
(f)约0.2%重量比至2.0%重量比的一种或多种植物制剂,所述植物制剂选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、芦荟凝胶和芦荟叶汁。
8.根据权利要求7所述的组合物,还包含约0.5%重量比至2.0%重量比阳离子表面活性剂。
9.一种抗微生物组合物,包含:
(a)约0.1%重量比至2.0%重量比的苯甲醇;
(b)约0.02%重量比至2.0%重量比的苯甲酸;
(c)约0.1%重量比至1.0%重量比的苯基乙醇;
(d)约0.02%重量比至1%重量比的倍半萜,其形式为单一倍半萜或倍半萜类混合物;
(e)约0.05%重量比至2.5%重量比的一种或多种精油,所述精油选自由以下物质组成的集合:牛至油、百里香酚、迷迭香油、肉桂油、高良姜油、石榴油和香茅草油;以及
(f)约0.05%重量比至2.0%重量比的一种或多种植物制剂,所述植物制剂选自由以下物质组成的集合:山葵提取物、葡萄柚提取物、柑橘提取物、金银花提取物、芦荟凝胶和芦荟叶汁。
10.一种伤口愈合组合物,包含:
(a)约0.1%重量比至0.5%重量比的苯甲醇;
(b)约0.2%重量比至1.0%重量比的氧化锌;
(c)约0.05%重量比至0.7%重量比的姜黄素;以及
(d)以下物质中至少两种:石榴油、迷迭香油、香茅草油、肉桂油、百里香酚和药鼠李油,每种物质含量约0.1%重量比至1.0%重量比。
11.一种清洁组合物,包含约1%重量比至5%重量比的香茅草油、约0.1%重量比至1%重量比的松树油、以及约5%重量比至20%重量比的柠檬酸。
12.一种抗真菌局部软膏,包含约0.5%重量比至5%重量的苯甲醇和一种或多种化合物,所述化合物选自由以下物质组成的集合:
(a)约0.04%重量比至0.5%重量比的植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、金银花提取物、雪松木提取物、山杨树皮提取物、柳树皮提取物、布拉米提取物、以及它们的组合;
(b)约0.04%重量比至1.05%重量比的精油,所述精油选自由以下物质组成的集合:香茅草油、肉桂油、牛至油、百里香酚、高良姜油、橙油、石榴油、金盏花油、以及它们的组合;以及
(c)约0.2%重量比至2.0%重量比的天然有机酸。
13.一种食品消毒剂,包含:
(a)约0.5%重量比至5.0%重量比的苯甲醇;
(b)约0.2%重量比至1.0%重量比的植物提取物,所述植物提取物选自由以下物质组成的集合:山葵提取物、金银花提取物、雪松木提取物、山杨树皮提取物、柳树皮提取物、烟草提取物、柑橘提取物、以及它们的组合;
(c)约0.2%重量比至2.0%重量比的果酸;
(d)约0.1%重量比至5.0%重量比的表面活性剂;以及
(e)水
14.一种表面消毒剂,包含:
(a)约1.0%重量比至30%重量比的苯甲醇;
(b)约0.1%重量比至4.0%重量比的松树油和精油混合物,所述精油选自由以下物质组成的集合:香茅草油、橙油、肉桂叶油、桂皮油、以及它们的组合;
(c)约2%重量比至10%重量比的果酸;
(d)约5%重量比至25%重量比的表面活性剂;以及
(e)水。
15.根据权利要求14所述的表面消毒剂,还包含3-50%重量比的脂肪醇。
16.一种消毒剂,包含:
(a)约2.5%重量比至10%重量比的精油,所述精油选自由以下物质组成的集合:香茅草油、橙油、肉桂油、以及它们的组合;
(b)约0.5%重量比至5.0%重量比的松树油;
(c)约25%重量比至50%重量比的表面活性剂;
(d)约10%重量比至20%重量比的果酸;
(e)约20%重量比至40%重量比的脂肪醇;以及
(f)水。
17.一种杀虫剂,包含:
(a)约5.0%重量比至20%重量比的苯甲醇;
(b)约0.01%重量比至2.0%重量比的烟草提取物;
(c)约0.01%重量比至2.0%重量比的香茅草油;
(d)约0.5%重量比至4.0%重量比的雪松木油;以及
(e)约0.01%重量比至2.0%重量比的咖喱叶油。
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CA2890395A1 (en) | 2013-05-10 |
IN2014CN04034A (zh) | 2015-10-23 |
AU2012333187A1 (en) | 2014-06-26 |
WO2013066403A1 (en) | 2013-05-10 |
CA2890395C (en) | 2021-03-16 |
EP2775847A4 (en) | 2016-01-13 |
JP2015501330A (ja) | 2015-01-15 |
EP2775847A1 (en) | 2014-09-17 |
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