JP4687874B2 - 徐放性ゲル組成物 - Google Patents
徐放性ゲル組成物 Download PDFInfo
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- JP4687874B2 JP4687874B2 JP2005038636A JP2005038636A JP4687874B2 JP 4687874 B2 JP4687874 B2 JP 4687874B2 JP 2005038636 A JP2005038636 A JP 2005038636A JP 2005038636 A JP2005038636 A JP 2005038636A JP 4687874 B2 JP4687874 B2 JP 4687874B2
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Description
このように、イソチオシアン酸アリルのような揮発性の薬剤の徐放性を付与させる方法として、近年、ゲル組成物とすることが提案されている。
特許文献2には、イソチオシアン酸化合物をポリエチレンオキサイド架橋物でゲル化させる鮮度保持剤が記載されている。
特許文献3には、イソチアン酸化合物をカラギーナン、ジュランガム等の天然粘質多糖類を用いてゲル化させる鮮度保持剤が記載されている。
また、本発明に関連して、特許文献4には、水溶性高分子、アルコキシシラン、及び香料からなる吸水性有機無機複合被膜が記載されている。
(1)アルコールに可溶な高分子化合物と、式(I)
(2)揮発性薬剤が、イソチオシアン酸エステルであることを特徴とする(1)記載の徐放性ゲル組成物に関し、
(3)イソチオシアン酸化合物がイソチオシアン酸アリルであることを特徴とする(2)記載の徐放性ゲル組成物に関し、
(4)アルコールに可溶な高分子化合物が、ヒドロキシプロピルセルロースであることを特徴とする(1)〜(3)のいずれかに記載の徐放性ゲル組成物に関し、
(5)M1が、Tiであることを特徴とする(1)〜(4)のいずれか記載の徐放性ゲル組成物に関する。
(6)アルコールに可溶な高分子化合物、式(I)
本発明の徐放性ゲル組成物は、アルコールに可溶な高分子化合物と、前記式(I)で表される化合物から形成された有機・無機複合体、揮発性薬剤、及びアルコールを含有することを特徴とする。
置換基を有していてもよいC2〜C10アルケニル基のアルケニル基としては、ビニル基、プロペニル基、ブテニル基、ペンテニル基等が挙げられる。
置換基を有していてもよいC3〜C8シクロアルキル基のシクロアルキル基としては、シクロプロピル基、シクロペンチル基、シクロヘキシル基、シクロヘプチル基等が挙げられる。
置換基を有していてもよいアリール基のアリール基としては、フェニル基、1−ナフチル基、2−ナフチル基等が挙げられる。
置換基を有していてもよいアラルキル基のアラルキル基としては、ベンジル基、フェネチル基等が挙げられる。
nは、0から(m−2)以下のいずれかの整数を表す。nが2以上のとき、R1は、同一であっても、相異なっていてもよく、また、(m−n)が2以上のときXは、同一であっても、相異なっていてもよい。
ヒドロキシプロピルセルロース(分子量:55,000〜70,000、商品名:HPC−L、日本曹達株式会社製)10wt%エタノール溶液10.0gを蓋付きテフロン(登録商標)製容器に入れ(HPC含有量:1.0g)、その中に、Ti(OBu)4(日本曹達株式会社製)1.32gを加えて30分攪拌した後、イソチオシアン酸アリル(試薬特級、和光純薬社製)1.4gを加えて1時間攪拌した。この溶液を冷凍庫中へ移して30分間冷却した後に取り出した。そこへ攪拌しながら蒸留水0.3mlをシリンジを用いてゆっくりと滴下していき、Ti(OBu)4の加水分解・重縮合を進行させた。蒸留水滴下中に系の粘性が徐々に向上し、滴下終了数十秒後にゲル化して、徐放性ゲル組成物Aを得た。
実施例1で調製した徐放性ゲル組成物A2gをチャック付ポリ袋(商品名:ユニパック、品番:K−4、株式会社生産日本社製)に入れ、チャック付ポリ袋を4重にした。このポリ袋を靴中に入れ、8時間靴を履いた後、靴中のアンモニア濃度を検知管(株式会社ガステック製)を用いて、靴下中の臭気をハンディにおいモニター(神栄株式会社製)を用いて測定した。なお、比較として、徐放性ゲル組成物を使用しない場合(ブランク)の靴中のアンモニア濃度、及び靴下中の臭気を測定した。その結果を表1に示す。
HPC−L(日本曹達株式会社製)10wt%エタノール溶液12.0gを蓋付きテフロン(登録商標)製容器に入れ(HPC含有量:1.2g)、その中に、Ti(OBu)42.0gを加えて30分攪拌した後、イソチオシアン酸アリル2.5gを加えて1時間攪拌した。この溶液を冷凍庫中へ移して30分間冷却した後に取り出した。そこへ蒸留水0.45mlをシリンジを用いてゆっくりと滴下していき、Ti(OBu)4の加水分解・重縮合を進行させた。蒸留水滴下中に系の粘性が徐々に向上し、滴下終了数十秒後にゲル化して、徐放性ゲル組成物を得た。
実施例3で調製した徐放性ゲル組成物Bの全量を、450mlのマヨネーズ瓶に入れ、蓋をして密閉した。この密閉されたマヨネーズ瓶中の上部から約3cmのところのガスをシリンジにて2.5cc採取し、ガスクロマトグラフィー(GC−14A:株式会社島津製作所製)によりイソチオシアン酸アリルのガス濃度を算出した。比較として、イソチオシアン酸アリル2.50gを入れたマヨネーズ瓶中のイソチオシアン酸アリルのガス濃度を算出した。試験結果を図1に示す。
ガスクロマトグラフィー測定条件:
・検出器:FID
・カラム:GasukuroPack 54(60/80mesh;溶剤用)2m
・カラム温度:200℃
・INJECTION:200℃
・DET:200℃
・キャリアーガス:N2 1.5kg/cm2
・FID:Air 0.2kg/cm2、H2 0.7kg/cm2
Claims (6)
- 揮発性薬剤が、イソチオシアン酸エステルであることを特徴とする請求項1記載の徐放性ゲル組成物。
- イソチオシアン酸化合物がイソチオシアン酸アリルであることを特徴とする請求項2記載の徐放性ゲル組成物。
- アルコールに可溶な高分子化合物が、ヒドロキシプロピルセルロースであることを特徴とする請求項1〜3のいずれかに記載の徐放性ゲル組成物。
- M1が、Tiであることを特徴とする請求項1〜4のいずれか記載の徐放性ゲル組成物。
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