CN104023675B - 可膨胀椎间植入物 - Google Patents
可膨胀椎间植入物 Download PDFInfo
- Publication number
- CN104023675B CN104023675B CN201280062573.6A CN201280062573A CN104023675B CN 104023675 B CN104023675 B CN 104023675B CN 201280062573 A CN201280062573 A CN 201280062573A CN 104023675 B CN104023675 B CN 104023675B
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- China
- Prior art keywords
- parts
- component
- oblique portion
- wedge
- intervertebral implant
- Prior art date
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- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
- A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
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- A—HUMAN NECESSITIES
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Abstract
提供了一种椎间植入物。该椎间植入物包括第一部件,该第一部件包括外部组织接合表面和内表面。第二部件连接到第一部件并且能够从第一部件相对地移动。该第二部件包括外部组织接合表面和内表面。第二部件包括致动件。第三部件被设置用于接合操作并且能够相对于第一部件和第二部件进行移动。该第三部件至少包括第一斜部和与第一斜部轴向间隔的第二斜部。致动件能够与第三部件接合,以实现楔形件的轴向平移,使得各斜部接合第一部件和第二部件中至少一个的内表面,以使各部件在第一构造和第二构造之间移动。公开了使用方法。
Description
技术领域
本发明总体上涉及用以治疗肌骨失常的医疗装置、***和方法,特别涉及用以治疗脊柱的可膨胀椎间植入物和方法。
背景技术
诸如退行性椎间盘病、椎间盘突出症、骨质疏松症、脊椎前移、椎管狭窄、脊柱侧凸和其它弯曲异常、脊柱后凸、肿瘤和骨折等的脊柱病症可能由包括因受伤和衰老引起的创伤、疾病和功能退化等多种因素导致。典型地,脊柱病症导致包括疼痛、神经损伤、部分或完全失去移动能力等症状。例如,在椎间盘塌陷后,由于施加在神经和脊柱上的压力,会产生剧痛和不适。
诸如药物治疗、康复治疗和锻炼治疗等非手术治疗可能是有效的,但是不能够减轻与这些病症相关联的症状。对这些脊柱病症的手术治疗包括融合、固定、椎间盘切除、椎板切除和可植入假体。这些治疗可以使用椎间植入物。本发明描述了对现有技术的改进。
发明内容
因此,本文公开了一种可膨胀椎间植入物***和方法。在一个实施例中,提供了椎间植入物。该椎间植入物包括第一部件,该第一部件包括外部组织接合表面和内表面。第二部件连接到该第一部件并且能够从该第一部件相对地移动。该第二部件包括外部组织接合表面和内表面。该第二部件包括致动件。第三部件被设置用以接合操作,并能够相对于第一部件和第二部件移动。该第三部件至少包括第一斜部和与该第一斜部轴向间隔开的第二斜部。该致动件能够与第三部件接合,以实现楔形件的轴向平移,使得斜部接合第一部件和第二部件中至少一个的内表面,以使各部件在第一收缩构造和第二膨胀构造之间移动。
在一个实施例中,椎间植入物包括活塞部件,该活塞部件包括终板表面和 以与该终板表面相反的定向设置的内表面。该活塞部件在前端和后端之间延伸。基底部件包括终板表面和以与该基底部件的终板表面相反的定向设置的内表面。该基底部件在前端和后端之间延伸。该基底部件在相应后端附近可枢转地连接到活塞部件。该基底部件的后端包括螺纹腔。螺钉被构造成置于该螺纹腔中。楔形件被设置以用于接合操作,并且能够相对于活塞部件和基底部件进行移动。该楔形件包括具有第一高度和第一倾斜角的第一斜部以及具有第二高度和第二倾斜角的第二斜部。第一斜部与第二斜部轴向间隔开。该螺钉能够与楔形件接合以实现该楔形件的轴向平移,使得各斜部接合第一部件的内表面,以使第一部件相对于第二部件枢转,使得各部件在第一收缩构造和第二膨胀构造之间膨胀。
在一个实施例中,提供了一种治疗脊柱的方法。该方法包括以下步骤:提供椎间植入物,该椎间植入物包括:第一部件、第二部件和第三部件,该第一部件具有前端和后端,该第一部件包括外部组织接合表面和内表面,该第二部件具有前端和后端,该第二部件在相应后端附近可枢转地连接到第一部件,该第二部件包括外部组织接合表面和内表面,该第二部件包括致动件,该第三部件被设置用于接合操作并且能够相对于第一部件和第二部件移动,该第三部件至少包括第一斜部和与该第一斜部轴向间隔的第二斜部;将处于收缩构造的该椎间植入物沿身体的基本上后侧入路引入椎体间空间中;以及,将致动件接合该第三部件以实现第三部件相对于第一部件和第二部件的轴向平移,使得各斜部接合第一部件和第二部件中至少一个的内表面,以将该椎间植入物膨胀到第二膨胀构造。
附图说明
通过结合以下附图的具体实施方式,本发明将变得更加显而易见,附图中,
图1是根据本发明原理的***的植入物的一个具体实施例的立体图;
图2是图1所示植入物的立体图;
图3是图1所示植入物的侧视图;
图4是图1所示植入物的侧视图;
图5是图1所示植入物的侧向剖视图;
图6是图1所示植入物的侧向剖视图;
图7是图1所示植入物的各部件的一个实施例的立体图;
图8是图1所示植入物的立体剖面图;
图9是图1所示植入物的一个实施例的平面图;
图10是图9所示植入物的平面图;
图11是图1所示植入物的一个实施例的立体剖面图;
图12是图1所示植入物的一个实施例的侧视图;
图13是图12所示植入物的侧视图;
图14是根据本发明的原理与椎体一起设置的***的各部件的侧视图;
图15是图14所示***的各部件和椎体的侧视图;
图16是图14所示***的各部件和椎体的侧视图;
图17是图1所示植入物的一个实施例的立体图;
图18是图17所示植入物的立体剖面图;
图19是图17所示植入物的各部件的立体图;
图20是图17所示植入物的立体剖面图;
图21是图17所示植入物的立体剖面图;
图22是图1所示植入物的一个实施例的立体图;
图23是图22所示植入物的平面图;
图24是图22所示植入物的侧向剖视图;
图25是图22所示植入物的侧向剖视图;
图26是图22所示植入物的侧向剖视图;
图27是图22所示植入物的各部件的一个实施例的立体图;以及
图28是图22所示植入物的部件的立体图。
具体实施方式
根据用以治疗肌骨失常的医疗装置,更特别地,根据用以治疗脊柱的可膨胀椎间植入物***和相关方法,讨论了本文公开的可膨胀椎间植入物***和相关使用方法的示例性实施例。可以设想的是,该植入物***可以提供例如融合、解压、矢状面平衡恢复和阻止沉入例如椎体终板表面等组织的功能。可以进一 步设想的是,该***包括椎间植入物,该椎间植入物在***椎间盘空间后膨胀并且具有数种特征,例如,可以灵活地***椎间盘空间使得在外科手术、神经根解压、膨胀以恢复矢状面平衡的过程中只需移除较少的骨,以使在例如腰椎应用中为前侧提供相对于后侧更多的膨胀。
在一个实施例中,通过直接外侧入路将可膨胀的椎间植入物***用于椎间盘空间,使得椎间植入物的远端比椎间植入物的近端膨胀得更多,以恢复脊柱前凸。在一个实施例中,可膨胀椎间植入物包括接合第一椎体终板的基底部件、接合在相反定向上设置的第二椎体终板的活塞部件以及在该基底部件和活塞部件之间被驱动以驱动基底部件和活塞部件分离的双斜部部件。可以考虑的是,该双斜部部件通过外螺纹部件而相对于基底部件进行移动。还可以考虑的是,该双斜部部件可以包括用以将活塞部件和基底部件在可膨胀椎间植入物的近端和远端处驱动分开的两个楔形件。可以设想的是,各楔形件的高度和角度选择性地提供在可膨胀椎间植入物的各端上的膨胀量和膨胀率。例如,当可膨胀椎间植入物膨胀时,在可膨胀椎间植入物的远部和/或前部上的较陡和/或较高楔形件驱动脊柱前凸。
可以设想的是,本文公开的可膨胀椎间植入物和使用方法可以用以通过微创或经皮***技术来实现椎骨的融合。在一个实施例中,所公开的可膨胀椎间植入物和使用方法可以通过用于竖直膨胀以在椎体中产生脊柱前凸的装置而提供更好的脊柱治疗。可以考虑的是,本文公开的可膨胀椎间植入物和使用方法提供相对较大体积的腔,以在后填充(post-packing)例如移植骨等至少一种中间件。
可以设想的是,本发明可以用于治疗诸如退行性椎间盘病、椎间盘突出症、骨质疏松症、脊椎前移、椎管狭窄、脊柱侧凸和其它弯曲异常、脊柱后凸、肿瘤和骨折等脊柱病症。可以考虑的是,本发明可以用于其它骨骼和与骨相关的应用,包括与诊断学和治疗学相关联的应用。还可以考虑的是,公开的可膨胀椎间植入物可以在外科治疗中可替换地用于处于伏卧或背卧位置的病人,和/或将各种手术入路应用于脊骨,所述入路包括前部、后部、后部中线、中间、侧部、后侧和/或前侧入路以及在身体其它部位中。可替换地,本发明的可膨胀椎间植入物也可以用于治疗脊柱的腰部、颈部、胸部和骨盆区域的手术中。本 发明的可膨胀椎间植入物和方法也可以例如在训练、试验和演示中用于动物、骨骼模型和其它非生物基质。
结合形成本发明一部分的附图,参照以下本发明的具体实施方式,可以更容易地理解本发明。应当理解的是,本发明不限于本文所述和/或所示的特定装置、方法、条件或参数,并且本文所使用的术语目的是仅通过示例来描述具体实施例,而不是意为限制所要求保护的本发明。而且,如说明书中所使用的并包括所附权利要求中所使用的,单数形式“一”、“一个”、“该”包括复数情况,并且所提到的具体数值至少包括该具体值,除非上下文中另有其它说明。范围可以在本文中表达为从“大约”或“接近”一个具体值和/或到“大约”或“接近”另一个具体值。当表达这样的范围时,另一实施例包括从一个具体值和/或到另一具体值。类似地,如果各值通过使用先行词“大约”而表达为近似值,那么,将会理解的是,该具体值形成另一实施例。也应理解的是,例如水平、竖直、顶、上、下、底、外、内、末端(表示位置或定位)、左和右、前、后等所有的空间参照术语都可以在本发明的范围内变化。例如,参照术语“高”和“低”是相对于另一事物的,并且仅用于上下文中,但是不一定是指“上”和“下”。
另外,如说明书中使用的并包括所附权利要求,“治疗”疾病或病情涉及执行程序,该程序可以包括为病人用药以减轻该疾病或病情的迹象或症状。在该疾病或病情的迹象或症状出现之前以及之后都可以产生减轻的效果。因此,治疗包括预防疾病或不良的病情(例如,防止疾病发生在可能已对该病进行预处置但尚未诊断为患有该病的病人身上)。另外,治疗不要求完全地缓解迹象或症状,不要求治愈,并且特别地,包括只对病人具有轻微效果的程序。治疗可以包括抑制疾病,例如阻止病情发展,或减缓疾病,例如使疾病消退。例如,治疗可以包括减少急性或慢性炎症;减轻痛苦并缓和及诱导新韧带、骨和其它组织的再生;在外科手术中作为辅助;和/或任何修护程序。而且,如说明书中使用的并包括所附权利要求,除非另有具体说明,否则,术语“组织”包括软组织、韧带、腱、软骨和/或骨。
以下讨论内容包括对根据本发明原理的可膨胀椎间植入物和使用该可膨胀椎间植入物的相关方法的描述。以下内容也公开了可替换实施例。现在详细参照在附图中示出的本发明的示例性实施例。现在参照图1至图4,其示出了 根据本发明原理的、包括椎间植入物40的可膨胀椎间植入物***的各部件。
该***的各部件可以根据具体用途和/或医师的偏好而由适用于医学应用的生物可接受材料制成,这些材料包括金属、合成聚合物、陶瓷和骨质材料,和/或它们的化合物。例如,***的各部件可以各自或整体地由以下材料制成:如不锈钢合金、商用纯钛、钛合金、五级钛、超弹性钛合金、钴铬合金、不锈钢合金、超弹性金属合金(例如,镍钛诺、超弹塑性金属,如由日本丰田汽车材料股份有限公司(Toyota Material Incorporated of Japan)生产的商标为 的材料)、陶瓷和它们的化合物,如磷酸钙(例如,由Biologix Inc.公司生产的商标为SKELITETM的材料),诸如包括聚醚醚酮(PEEK)、聚醚酮酮(PEKK)和聚醚酮(PEK)的聚芳基醚酮(PAEK)的热塑性塑料、碳—聚醚醚酮化合物、聚醚醚酮—硫酸钡(BaSO4)聚合橡胶、聚对苯二甲酸乙二醇酯(PET)、纤维、硅树脂、聚氨酯、硅—聚氨酯共聚物、聚合橡胶、聚烯烃橡胶、水凝胶、半刚性或刚性材料、弹性体、橡胶、热塑性弹性体、热固性弹性体、弹性化合物、包括聚亚苯基、聚酰胺、聚酰亚胺、聚醚酰亚胺、聚乙烯、环氧基树脂的刚性聚合物、包括自体植入物、同种异体植入物、异种植入物或转基因皮质和/或皮松质骨的骨质材料,以及组织生长或分化因子、诸如金属和钙基陶瓷的化合物、聚醚醚酮和钙基陶瓷的化合物、聚醚醚酮和再吸收聚合物的化合物等部分再吸收材料、诸如磷酸钙、磷酸三钙(TCP)、羟磷灰石(HA)—磷酸三钙、硫酸钙等钙基陶瓷的全部再吸收材料、或诸如聚交酯、聚乙交酯、聚酪氨酸碳酸酯、聚已酸内酯以及它们的组合等其它再吸收聚合物。***的各个部件可以由包括上述材料的材料化合物制成,以实现诸如强度、刚度、弹性、柔性、可塑性、生物力学性能、耐久性和射线可透性或成像性等各种所需特性。该***的各部件也可以各自或整体地由诸如两个或多个上述材料组合而成的非均质材料制成。
包括椎间植入物40的该***可以在融合和固定手术程序中用作稳定装置,例如用以为患有脊柱病症的病人提供椎体间的高度恢复、解压、矢状面平衡恢复和/或阻止沉入椎体终板。该椎间植入物***的各部分可以整体形成、一体化连接或者包括例如上述的紧固元件和/或仪器。
椎间植入物40限定纵向轴线a并在第一端和第二端之间延伸,其中第一 端例如为前端42,第二端例如为后端44。椎间植入物40包括第一部件和第二部件,其中第一部件例如为活塞部件46,第二部件例如为连接到活塞部件46的基底部件48。基底部件48通过铰接部50可移动地安装到活塞部件46,以方便部件46、48之间的枢转连接。如将描述的,部件46、48能够相对移动以使椎间植入物40在第一构造和第二构造之间膨胀和收缩。可以考虑的是,部件46、48可以整体形成和/或通过活动铰接部连接。还可以考虑的是,替换地,基底部件48可以通过一体化连接、压合、螺旋、粘合和/或诸如夹具和/或螺钉之类的紧固元件而连接到活塞部件42。可以设想的是,椎间植入物40可以包括一个或多个部件。
活塞部件46包括外部组织接合表面,例如终板表面52。终板表面52限定在其中延伸的、基本为矩形的开口53。可以设想的是,该开口53可以构造用于填充至少一种中间件(agent),例如移植骨。还可以设想的是,该开口53可以具有诸如椭圆形、长方形、三角形、正方形、多边形、不规则形、均匀、非均匀、偏置、交错、波形、弧形、可变和/或锥形等可替换构造。可以考虑的是,终板表面52可以包括一个或多个开口。
终板表面52构造成接合椎体的终板,并包括构造成加强与椎骨组织之间固定和/或夹紧的多个凸起元件54。凸起元件54设置成横向于纵向轴线a。可以设想的是,根据具体应用的要求,终板表面52的所有部分或仅一部分可以具有用以加强与组织之间固定效果的可替换表面构造,例如,粗糙的、弧形的、波形的、网格的、渗透的、半渗透的、凹形的和/或有纹理的表面构造。还可以设想的是,凸起元件54可以相对于轴线a以可替换的定向设置,例如,垂直定向和/或以诸如锐角或钝角等其它角度定向,同轴,和/或可以偏置或交错。
活塞部件46包括内表面56,该内表面56被设置成面向与终板表面52所面向的定向和/或方向相对的定向和/或方向。终板表面52被定向成面向椎体终板组织的方向,内表面56被定向成面向相反的方向。内表面56是基本上光滑或平坦的,并被构造成接合第三部件的表面,例如接合楔形件58的表面,使得楔形件58能够相对于部件46、48移动。
活塞部件46包括以大体线性的构造沿纵向轴线a在第一端和第二端之间延伸的第一延伸部60和第二延伸部62,第一端例如为前端64,第二端例如为 后端66。延伸部60、62与端部64、66以整体形式形成。可以设想的是,可替换地,延伸部60、62可以通过一体化连接、压合、螺纹连接、粘合和/或诸如铰接部、夹具和/或螺钉等的紧固元件连接到端部64、66。延伸部60、62沿相对于纵向轴线a基本平行的定向设置。可以考虑的是,延伸部60和/或62可以相对于纵向轴线a在诸如垂直、会聚、分开和/或其它诸如锐角或钝角的角度定向、同轴等可替换定向上设置,和/或可以偏置或交错。可以设想的是,延伸部60、62能够以诸如曲率半径、偏置和/或交错之类的替代构造延伸。还可以设想的是,延伸部60、62可以具有诸如椭圆形、长方形、三角形、矩形、正方形、多边形、不规则形、均匀、非均匀、可变、中空和/或锥形之类的多种横截面构造。
延伸部60、62各自包括内表面56的至少一部分,该部分接合楔形件58表面的至少一部分,以使椎间植入物40在第一构造和第二构造之间膨胀和收缩,如将描述的。例如,延伸部60、62各自包括接合基底部件48的平坦部68、第一倾斜部70、凹部72、过渡部74和第二倾斜部76。部分68、70、72、74、76都沿延伸部60、62连续设置。倾斜部70、76设置成与轴线a成一定角度。
基底部件48包括外部组织接合表面,例如终板表面78。可以设想的是,终板表面78可以包括构造用于填充例如移植骨等至少一个中间件的一个或多个开口。终板表面78构造成接合椎体的终板,并包括构造成加强与椎骨组织之间的固定和/或夹紧的凸起元件80。凸起元件80设置成横向于纵向轴线a。可以设想的是,终板表面78的所有部分或仅一部分可以具有与本文所述可替换实例类似的、用以加强与组织之间固定的可替换表面构造。还可以设想的是,凸起元件80能够以类似于本文所述可替换实例的方式相对于纵向轴线a在可替换的定向上设置。
基底部件48包括内表面82,该内表面82被设置成面向与终板表面78所面向的定向和/或方向相反的定向和/或方向。终板表面78被定向成面向椎体终板组织的方向,而内表面82被定向成面向相反的方向。内表面82是平面的,并且基本上光滑或平坦,且被构造成接合楔形件58的表面。内表面82接合楔形件58的表面使得楔形件58能够相对于部件46、48移动。
基底部件48沿纵向轴线a在第一端和第二端之间以大体线性的构造延伸, 第一端例如为前端84,第二端例如为后端86。后端86包括限定诸如螺纹开口90之类的细长形腔室的壁88。诸如螺钉92之类的致动件被构造成设置在螺纹开口90中,并且延伸到由楔形件30固定的远端94。
螺钉92能够相对于壁88沿诸如顺时针的第一方向和沿诸如逆时针的第二相反方向进行旋转。螺钉92构造成以螺纹接合的方式与螺纹开口90配合,并且远端94由壁98固定并能够在其中自由转动。使得螺钉92接合开口90并且沿选定方向转动,使得该螺钉92与开口90螺纹连接。螺钉92被构造用于沿第一轴向和第二轴向相对于壁88平移。
如图5和图6所示,远端94包括凸缘96,该凸缘接合楔形件58的壁98以通过楔形件58保持螺钉92。远端94延伸通过壁98并包括减小的直径100,使得远端94相对于壁98转动,以方便螺钉92和楔形件58的轴向平移。减少的直径100方便了螺钉92的邻近表面102与壁98的接合,以沿箭头A所示第一方向来驱动和轴向平移楔形件58。凸缘96接合壁98以沿箭头B所示的第二相反方向牵拉和轴向平移楔形件58。
螺钉92与楔形件58固定在一起以实现楔形件58轴向平移,使得楔形件58能够相对于部件46、48移动,以如将要描述的使椎间植入物40在第一构造和第二构造之间膨胀和收缩。螺钉92与仪器或工具(未示出)接合,以根据具体应用的要求在各种构造中方便椎间植入物40的各部件的致动及其设置。
基底部件48在后端66、86的附近由铰接部50可枢转地连接到活塞部件46,以方便部件46、48之间的枢转连接。后端66包括构造成设置在后端86的细长形槽孔106中的销104。销104能够顺着槽孔106沿横向于纵向轴线a的轴线移动,以方便椎间植入物40在第一构造和第二构造之间膨胀和收缩。
楔形件58以中间定向的方式与部件46、48一起设置。楔形件58包括接合部件46的第一表面107和接合部件48的第二表面108,使得楔形件58能够移动,以相对于部件46、48进行轴向平移。楔形件58包括沿纵向轴线a设置的第一导轨部110和第二导轨部112,第一导轨部110和第二导轨部112可移动地接合部件46、48,以使椎间植入物40在第一构造和第二构造之间膨胀和收缩。
第一导轨部110包括第一斜部和第二斜部,第一斜部例如为前楔部114, 第二斜部例如为后楔部116。前楔部114沿导轨部110与后楔部116轴向间隔开。前楔部114具有第一高度h1并且相对于纵向轴线a具有第一倾斜角α1。可以设想的是,高度h1的范围可以在3毫米(mm)至7毫米之间。还可以设想的是,角度α1的范围可以在30度至60度之间。
后楔部116具有第二高度h2并且相对于纵向轴线a具有第二倾斜角α2。可以设想的是,高度h2的范围可以在1毫米(mm)至5毫米之间。可以设想的是,角度α2的范围可以在4度至30度之间。在一个实施例中,高度h1大于高度h2。在一个实施例中,角度α1大于角度α2。
导轨部110包括设置在楔部114、116之间的突出部118,使得楔部114、116轴向间隔并且也将楔部114与楔部116连接在一起。楔部114、116和突出部118沿导轨部110连续设置。可以考虑的是,楔部114、116在前端42和后端44处将部件46、48驱动分开,以方便椎间植入物40在第一构造和第二构造之间膨胀和收缩。还可以考虑的是,楔部114、116的高度和/或角度调节至少在导轨部110附近的椎间植入物40的膨胀量和膨胀率。可以设想的是,楔部114、116以整体形成,并由紧固元件或独立和不同的结构连接。
导轨部112包括第三斜部和第四斜部,第三斜部例如为前楔部120,第四斜部例如为后楔部122。前楔部120与后楔部122沿导轨部112轴向间隔开。前楔部120具有高度h1和倾斜角α1。后楔部122具有高度h2和倾斜角α2。
导轨部112包括设置在楔部120、122之间的突出部124,使得楔部120、122轴向间隔。突出部124将楔部120与楔部122连接在一起。楔部120、122和突出部124沿导轨部112连续设置。可以考虑的是,楔部120、122在前端42和后端44处将部件46、48驱动分开,以方便椎间植入物40在第一构造和第二构造之间膨胀和收缩。还可以考虑的是,楔部120、122的高度和/或角度调节至少在导轨部112附近的椎间植入物40的膨胀量和膨胀率。可以设想的是,楔部120、122以整体形成,并由紧固元件或独立和不同的结构连接。
导轨部110、112各自包括第一表面107的至少一部分,该部分接合部件46内表面56的至少一部分,以使椎间植入物40在第一构造和第二构造之间膨胀和收缩。例如,表面107的包括沿导轨部110设置的楔部114、116和突出部118的部分可滑动地接合沿延伸部60设置的部分68、70、72、74、76。表 面107的包括沿导轨部112设置的楔部120、122和突出部124的部分可滑动地接合沿延伸部62设置的部分68、70、72、74、76。导轨部110、112每一个也都包括表面108的至少一部分,该部分可滑动地接合内表面82的对应于延伸部60、62的至少一部分。
导轨部110、112沿近端方向和/或后部方向延伸,以绕后端44附近的壁88设置。导轨部110、112在椎间植入物40的各部件轴向平移期间绕壁88移动。
在一个实施例中,如图7和图8所示,活塞部件48包括诸如篮状部202的接收部,该篮状部202构造成设置例如移植骨的至少一种中间件。楔形件58包括诸如篮状部204的接收部,该篮状部204构造成设置例如移植骨的至少一种中间件。在第一收缩构造中,篮状部202、204以并排构造的方式连续设置。当椎间植入物40膨胀到第二膨胀构造时,篮状部202、204平移成竖直堆置构造,使得移植骨可以生长通过处于连接状态的篮状部202、204。篮状部202、204每个都包括多个开口,这些开口允许骨在篮状部202、204之间生长。在一个实施例中,篮状部202是具有恒定体积的上篮状部,而篮状部204是具有恒定体积的下篮状部。篮状部202、204在被递送到手术部位之前由移植骨填充,并以并排构造连续设置。篮状部202、204具有斜界面,该斜界面在椎间植入物40从第一收缩构造膨胀到第二膨胀构造时允许保持篮状部202、204之间的接触,并允许篮状部202、204从并排构造过渡到堆置构造和/或顶-底的构造。在篮状部202、204之间的该界面具有开口,使得在篮状部202、204之一内的移植骨可以与篮状部202、204中的另一个内的移植骨交界。该构造允许移植骨从第一椎体终板先通过篮状部202然后通过篮状部204或者先通过篮状部204然后篮状部202而融合到第二椎体终板。
在一个实施例中,如图9和图10所示,椎间植入物40包括移植骨腔,该移植骨腔构造成具有与椎间植入物40一起设置的、可控体积的移植骨。椎间植入物40包括延伸穿过其主体和部件46、48以及58的开口206。开口206被构造成用以设置诸如移植骨的至少一种中间件。在第一收缩构造中,开口206限定长度L1和横截面面积,使得移植骨的体积v被置于开口206中。楔形件58的壁98设置在近端位置或后部位置中。当椎间植入物40膨胀到第二膨胀构 造时,植入物40的总体高度增加,并且壁98沿图6中箭头A所示的方向轴向平移,如本文所述。由于壁98轴向平移,开口206的横截面面积减少。壁98平移到远端位置或前部位置,使得开口206限定长度L2。椎间植入物40的各部件被定尺寸为,使得开口206的长度减少到长度L2以及植入物10高度的增加相结合,以在椎间植入物40的整个膨胀期间保持移植骨的大体恒定的体积V。此允许椎间植入物40在膨胀的任何高度处都保持移植骨的恒定体积。应考虑的是,用于保持移植骨体积的该构造避免了在椎间植入物40高度增加时移植骨在开口206中变得松弛。还应考虑的是,紧密填充的移植骨可以潜在地增加融合能力。在一个实施例中,椎间植入物40提供可控体积的移植骨,使得椎间植入物40的各部件被定尺寸成,开口206的长度减少到长度L2的速率快于椎间植入物40高度增加的速率。由此,当椎间植入物40膨胀时,移植骨的体积减少。当椎间植入物40膨胀时,椎间植入物40的该构造压紧移植骨。可以考虑的是在椎间植入物40中被压紧的移植骨可以增加第一椎体通过移植骨融合到第二椎体中的可能性。
在操作中,如图3至图6所示,椎间植入物40被接合以在第一构造和第二构造之间设置,使得椎间植入物40在椎间盘空间中膨胀。椎间植入物40与仪器(未示出)接合,以方便根据具体外科应用的要求致动椎间植入物40的各部件。
在第一构造中,例如在收缩构造中(图5),部件46、48以较低的轮廓定向方式与楔形件58一起设置,使得延伸部60、62的平坦部68以平齐接合的方式与内表面82一起设置。楔部114、120被设置成平齐接合延伸部60、62的相应倾斜部70,楔部116、122被设置成接合延伸部60、62的相应倾斜部76。突出部118、124被设置在延伸部60、62的相应凹部72内。
当根据具体外科应用的要求对椎间植入物40进行所需的定位后,操作螺钉92以轴向移动楔形件58。仪器接合螺钉92,以沿顺时针方向进行旋转。螺钉92沿箭头A所示的第一轴向进行轴向平移。当螺钉92轴向平移时,表面102接合壁98,以沿箭头A所示的方向轴向驱动楔形件58。楔部114、120可滑动地接合延伸部60、62的相应倾斜部70,楔部116、122可滑动地接合延伸部60、62的相应倾斜部76。由于楔形件58的轴向平移而导致的楔形件58表 面和部件46、48的可滑动接合操作使部件46相对于部件48以转动方式绕铰接部50进行枢转,使得部件46、48在第一收缩构造和第二膨胀构造(图6)之间膨胀。该构造方便了椎间植入物40的膨胀,使得前端42相对于后端44具有更大的膨胀率和膨胀量。应考虑的是,当椎体间植入物40膨胀时,较陡和/或较高的导轨部方便了脊柱前凸。
在一个实施例中,通过沿图6中箭头B所示的、与第一轴向相反的第二轴向操作楔形件58,椎间植入物40可以从膨胀构造收缩到处于膨胀构造和收缩构造之间的替代构造。可以设想的是,用以收缩椎间植入物40的、楔形件58的反向轴向运动可用以重新定位椎间植入物40或从体腔内移除椎间植入物40。当在膨胀构造中设置椎间植入物40时,为将椎间植入物40设置为另一构造,螺钉92沿逆时针方向转动,使得凸缘96接合壁98,以沿箭头B所示的第二相反方向牵拉和轴向平移楔形件58。
当楔形件58沿第二轴向进行轴向平移时,部件46绕铰接部50枢转,以朝向收缩构造转动,使得楔部114、120移动以接合相应的倾斜部70,楔部116、122移动以接合相应的倾斜部76,并且突出部118、124移动以设置在相应的凹部72中。根据应用,部件46、48可以返回到如图5所示的完全收缩构造。
在一个实施例中,如图11所示,包含顺时针螺纹294的、诸如夹紧螺母292的致动件设置在近端296处并且被构造成设置在螺纹开口90中。夹紧螺母292包括设置在远端300处并构造成用以螺纹接合楔形件58的逆时针螺纹298。壁98限定构造用以设置螺纹298的螺纹开口302。从上述椎间植入物40的第一收缩构造,夹紧螺母292***作以轴向移动楔形件58。该仪器接合夹紧螺母292以在螺纹开口90中转动螺纹294,并在开口302中转动螺纹298,以使椎间植入物40膨胀。当夹紧螺母292转动时,螺纹294、298的反向转动使夹紧螺母292驱动分开楔形件58和基底部件48,使得楔形件58轴向平移,如本文所述。楔形件58和部件46、48如上所述可滑动地接合,使得部件46、48在第一收缩构造和第二膨胀构造之间膨胀。
在一个实施例中,如图12和图13所示,椎间植入物40构造成在第一收缩构造和第二膨胀构造之间选择性的和/或可变的膨胀。可以设想的是,楔形件58的导轨部110、112的形状和大小可以选择性地调节椎间植入物40的膨胀。 楔部114、120都包括具有倾斜角β1的第一表面402以及具有倾斜角β2的第二表面404。楔部116、122具有倾斜角β1。角度β2大于角度β1。
椎间植入物40在第一构造和第二构造之间的膨胀包括初级膨胀和次级膨胀。楔部116、122和楔部114、120的表面402具有倾斜角β1,使得在初级膨胀中,前端42和后端44附近的椎间植入物40的膨胀基本相等,如箭头X所示。可以考虑的是,初级膨胀提供了椎间盘空间的解压。在膨胀了选定量后,根据表面402的长度,部件46的倾斜部70接合楔部114、120的表面404,以越过由于楔部116、120导致的膨胀。角度β2大于角度β1,使得如箭头Y所示的前端42膨胀量大于如箭头Z所示的后端44的膨胀量。可以考虑的是,次级膨胀使椎间盘空间的前侧相对于后侧具有更大的膨胀量,以提供脊柱前凸。可以设想的是,可以使用其它斜部构造,以仅在竖直定向上使椎间植入物40膨胀和/或在诸如胸椎等应用中驱动脊柱后凸。
在组装和使用中,该椎间植入物***用于外科手术中,如对包括椎骨V、椎间盘空间I和其附近的身体区域的病人脊柱进行融合处理,如本文中所讨论的。该椎间植入物***也可以用于诸如椎间盘切除术、椎板切开术、椎板切除术、神经根凝缩、椎间孔切开术、椎骨关节面切除术、解压和脊柱、髓核或椎间盘更换等其它外科手术中。
例如,如图14至图16所示,椎间植入物***可以用于外科关节融合术,例如,用于治疗脊柱及其体内相邻区域感染段的适用病情或伤情的椎间融合术,相邻区域例如为用于椎体V的第一椎骨V1(未示出)和第二椎骨V2(未示出)之间的椎间盘空间I。可以考虑的是,上述椎间植入物***的椎间植入物40可以***椎间盘空间I,以将关节接合表面间隔开,为椎体V提供支持并使椎体V的稳定最大化。还可以考虑的是,椎间植入物40提供椎体之间的高度恢复、解压、矢状面平衡恢复和/或阻止沉入椎体终板的功能。
在使用中,为了治疗椎体V中受影响的部段,医师通过诸如切开和缩紧组织等任何合适的方式通达包括椎体V的外科手术部位。可以设想的是,椎间植入物***可以以包括开放性手术、最低开放手术、微创手术和经皮手术植入等任何现有外科手术方法或技术进行使用,由此通过为该区域提供保护通道的最小切口或套筒而进入椎体V。一旦通达该手术部位,便执行用以治疗脊柱病症 的具体外科手术。然后,如以上关于图1至图13所述的,椎间植入物40用以加强该外科手术治疗。椎间植入物40可以作为预组装装置被递送或植入,或者可以在手术部位进行组装。椎间植入物40可以完全或部分地在手术部位处被调整、移除或更换。应考虑的是,椎间植入物***的一个或所有部件可以通过手动操作和/或徒手技术被递送到手术部位。还可以考虑的是,椎间植入物40可以从后部***,然后从前部和/或侧部和/或内部操作。
在病人体内制作一个切口,然后切割仪器(未示出)制造用于将椎间植入物40植入到病人体内的手术通道P。使用导引仪器(未示出)以在开始时分开椎骨V2和椎骨V1,如图14所示。使用套筒或套管S以进入椎间盘空间I并方便该椎间植入物***的部件的递送和通达。制备仪器(未示出)可以***到套筒或套管内并设置在椎间盘空间I中。该制备仪器可以用以去除包括椎间盘髓核和流体、邻近组织和/或骨、皮层的一些或全部椎间盘组织,从相对的椎骨V1、V2的终板表面刮去和/或去除组织,并且用于根据具体外科应用的要求对该区域进行抽吸和冲洗。
如图15所示,椎间植入物40被设置成上述第一收缩构造,并且沿箭头C所示的基本后部入路被递送通过手术通道P而进入椎间盘空间I,其中递送仪器(未示出)包括驱动器。根据具体手术应用的要求,该驱动器将椎间植入物40递送到椎骨V1和椎骨V2之间的经制备的椎间盘空间I中。
当对椎间植入物40进行所需的定位后,驱动器或其它仪器接合椎间植入物40,以方便致动椎间植入物40的部件。该驱动器接合螺钉92,以沿顺时针方向转动,使得螺钉92轴向平移以沿图15和图16中箭头D所示方向轴向驱动楔形件58。如图5和图6所示和描述的,楔部114、120可滑动地接合延伸部60、62相应的倾斜部70,楔部116、122可滑动地接合延伸部60、62相应的倾斜部76。由于楔形件58的轴向平移,楔形件58的表面和部件46、48的此类可滑动接合使部件46相对于部件48以转动方式绕铰链50枢转,使得部件46、48在第一收缩构造和第二膨胀构造之间膨胀,如图16所示。该构造方便了椎间植入物40的膨胀,使得前端42具有相对于后端44更大的膨胀率和膨胀量。可以考虑的是,在膨胀构造中,椎间植入物40提供了椎骨V1和椎骨V2之间的高度恢复、解压、矢状面平衡恢复和阻止沉入椎骨V1和椎骨V2的 终板中之类的功能。
可以设想的是,可以包括一个或多个椎间植入物40的椎间植入物***的各部件可以通过替换入路递送到手术部位。在一个实施例中,椎间植入物40被递送通过沿经椎间孔腰椎体间融合入路的手术通道而进入椎间盘空间I中,并被设置为膨胀构造。在一个实施例中,多个椎间植入物40被递送通过沿后部腰椎间融合入路的手术通道而进入椎间盘空间I中,并被设置为并排定向的膨胀构造。
在一个实施例中,当可能需要重新定位或从椎间盘空间I中移除椎间植入物40时,椎间植入物40可以如上所述从膨胀构造收缩到在膨胀构造和收缩构造之间的替代构造,以收缩椎间植入物40。在一个实施例中,椎间植入物***包括多个椎间植入物40,其可以以各种方式定尺寸和构造,和/或以并排接合的方式定向、间隔和/或交错。
在一个实施例中,椎间植入物***包括中间件,该中间件可以包括骨质增长促进材料,该骨质增长促进材料可以设置、填充或层置在椎间植入物***的各部件和/或各表面内部、上面或周围。诸如移植骨之类的骨质增长促进材料可以是颗粒材料,该颗粒材料包括诸如羟磷灰石的骨引导材料和/或诸如成骨蛋白(BMP)的骨诱导中间件,以加强椎间植入物40和附近椎体V之间的骨固定。
可以考虑的是,中间件和/或移植骨可以包括治疗性多聚核苷酸或多肽。可以进一步考虑的是,中间件和/或移植骨可以包括诸如生物兼容性金属等生物兼容性材料,和/或诸如钛元件、钛的金属粉或钛化合物等刚性聚合物,诸如同种异体植入物或异种植入物材料等无菌骨材料,诸如珊瑚和钙的合成物、羟磷灰石、磷酸钙和硫酸钙等合成骨质材料,例如缓释合成物等生物活性中间件,其中该生物活性中间件混合在生物再吸收聚合物中,当该聚合物在病人体内退化时,该聚合物以合适的时间依赖方式释放该生物活性中间件。适合的生物活性中间件包括例如成骨蛋白、生长和分化因子蛋白(GDF)以及细胞因子。椎间植入物40可以由诸如聚合物等可透放射性材料制成。可以包括无线指示件以在x光、荧光透视、计算机断层扫描或其它成像技术条件下辨识。可以设想的是,该中间件可以包括用以包括缓释等释放方式的一种或多种治疗性中间件和/或药理性中间件,以例如治疗疼痛、发炎和退化。
在一个实施例中,如图17至图21所示,椎间移植物***包括椎间移植物540,椎间移植物540类似于上述图1至图16所述的椎间移植物40及其部件。椎间移植物540限定纵向轴线aa并在前端542和后端544之间延伸。椎体间移植物540包括活塞部件546和连接到该活塞部件546的基底部件548。基底部件548由铰接部550可移动地安装到活塞部件546,以方便部件546、548之间的枢转连接。如将描述的,部件546、548能够相对移动,以使椎体间移植物540在第一构造和第二构造之间膨胀和收缩。
活塞部件546包括终板表面552。终板表面552限定基本为矩形的开口553。终板表面552被构造成接合椎体终板,并包括构造以加强与椎骨组织之间固定和/或夹紧的多个凸起元件554。凸起元件554被设置成横向于纵向轴线aa。
活塞部件546包括内表面556,该内表面556被设置成面向与终板表面552所面向的定向和/或方向相对的定向和/或方向。终板表面552被定向成面向椎体终板组织的方向,内表面556被定向成面向相反的方向。内表面556是大体光滑或平坦的,并被构造成接合楔形件558的表面,使得楔形件558能够相对于部件546、548移动。
活塞部件546包括以基本线性的构造沿纵向轴线aa在前端546和后端566之间延伸的第一延伸部560和第二延伸部562。延伸部560、562与端部564、566以整体形式形成。延伸部560、562沿相对于纵向轴线aa大体平行的定向设置。
延伸部560、562每个都包括内表面556的至少一部分,该部分接合楔形件558表面的至少一部分,以使椎间植入物540在第一构造和第二构造之间膨胀和收缩。延伸部560、562每个都包括接合基底部件548的部分568、倾斜部570和线性部576。部分568、570、576都沿延伸部560、562连续设置。倾斜部570被设置成与轴线aa成一定角度。
基底部件548包括终板表面578。终板表面578被构造成接合椎体的终板,并包括构造成加强与椎骨组织之间的固定和/或夹紧的多个凸起元件580。凸起元件580设置成横向于纵向轴线aa。基底部件548包括壁582,壁582限定构造以支持楔形件558可滑动移动的内表面。壁582被设置在椎间移植物540的相对的横侧上,使得楔形件558能够在基底部件548的内表面边界内移动。终 板表面578被定向成面向椎体终板组织的方向,而壁582被定向成面向楔形件558。楔形件558能够在基底部件548的内表面边界内相对于部件546、548移动。
基底部件548沿纵向轴线aa在前端584和后端586之间以大体线性的构造延伸。后端586包括支持诸如螺钉592的致动件的壁部588。壁部588固定螺钉592相对于基底部件548的位置,并且方便螺钉592在各壁部588之间的转动。螺钉592被构造成设置在壁部588和诸如由楔形件558的壁591所限定的螺纹槽孔590等螺纹腔之间。
螺钉592能够相对于壁部588和壁591沿诸如顺时针的第一方向和沿诸如逆时针的第二相反方向进行转动。螺钉592被构造成以螺纹接合的方式与螺纹槽孔590配合,并能够在其中自由转动。螺钉592沿顺时针方向转动,使得与螺纹槽孔590的接合可以沿图20和图21中箭头AA所示的第一方向轴向平移楔形件558。螺钉592沿逆时针方向转动,使得与螺纹槽孔590的接合可以沿箭头BB所示的第二相反方向轴向平移楔形件558。
螺钉592与部件548固定在一起,以实现楔形件558的轴向平移,使得楔形件558能够相对于部件546、548移动,以使椎间植入物540在第一构造和第二构造之间膨胀和收缩。螺钉592与仪器或工具(未示出)接合,以根据具体应用的要求在各种构造中方便椎间植入物540的各部件的致动及其设置。
基底部件548在后端566、586的附近由铰接部550可枢转地连接到活塞部件546,以方便部件546、548之间的枢转连接。后端566包括被构造成设置在后端586的细长形槽孔606中的销604。销604能够顺着槽孔606沿横向于纵向轴线aa的轴线移动,以方便椎间植入物540在第一构造和第二构造之间膨胀和收缩。
楔形件558以中间定向的方式与部件546、548一起设置。楔形件558包括接合活塞部件546的第一表面507和接合基底部件548的第二表面608,使得楔形件558能够移动,以相对于部件546、548进行轴向平移。楔形件558包括沿纵向轴线aa设置的第一导轨部610和第二导轨部612,第一导轨部610和第二导轨部612可移动地接合部件546、548,以使椎间植入物540在第一构造和第二构造之间膨胀和收缩。
导轨部610包括第一斜部和第二斜部,第一斜部例如为前楔部614,第二斜部例如为后楔部616。前楔部614沿导轨部610与后楔部616轴向间隔开。前楔部614具有类似于以上所述的高度和相对于纵向轴线aa的倾斜角。后楔部616具有类似于以上所述的高度和相对于纵向轴线aa的倾斜角。
导轨部610包括设置在楔部614、616之间的构件618,使得楔部614、616轴向间隔开。构件618将楔部614与楔部616连接在一起。楔部614、616和构件618沿导轨部610连续设置。可以考虑的是,楔部614、616在前端542和后端544处将部件546、548驱动分开,以方便椎间植入物540在第一构造和第二构造之间膨胀和收缩。还可以考虑的是,楔部614、616的高度和/或角度调节至少在导轨部610附近的椎间植入物540的膨胀量和膨胀率。可以设想的是,楔部614、616以整体形成,并由紧固元件或独立和不同的结构连接。
导轨部612包括第三斜部和第四斜部,第三斜部例如为前楔部620,第四斜部例如为后楔部622。前楔部620与后楔部622沿导轨部612轴向间隔开。楔部620、622具有类似以上所述的高度和倾斜角。
构件618设置在楔部620、622之间,使得楔部620、622轴向间隔开。构件618将楔部620与楔部622连接在一起。楔部620、622和构件618沿导轨部612连续设置。可以考虑的是,楔部620、622在前端542和后端544处将部件546、548驱动分开,以方便椎间植入物540在第一构造和第二构造之间膨胀和收缩。还可以考虑的是,楔部620、622的高度和/或角度调节至少在导轨部612附近的椎体间植入物540的膨胀量和膨胀率。可以设想的是,楔部620、622以整体形成,并由紧固元件或独立和不同的结构连接。
导轨部610、612每个都包括第一表面607的至少一部分,该部分接合活塞部件546内表面556的至少一部分,以使椎间植入物540在第一构造和第二构造之间膨胀和收缩。表面607的包括沿导轨部610设置的楔部614、616的部分可滑动地接合沿延伸部560设置的部分570、576。表面607的包括沿导轨部612设置的楔部620、622的部分可滑动地接合沿延伸部562设置的部分570、576。
导轨部610、612沿近端方向和/或后部方向延伸,以设置在后端544附近的壁部582中。导轨部610、612在椎间植入物40的各部件的轴向平移期间在 壁部582中移动。
活塞部件548包括诸如篮状部702的接收部,该篮状部702构造成设置诸如移植骨的至少一种中间件。楔形件58包括诸如篮状部704的接收部,该篮状部704构造成设置诸如移植骨的至少一种中间件。在第一收缩构造中,篮状部702、704以并排构造的方式连续设置。当椎体间植入物540膨胀到第二膨胀构造时,篮状部702、704平移成竖直堆置构造,使得移植骨可以生长通过处于连接状态的篮状部702、704。篮状部702、704各自包括多个开口,这些开口允许骨在篮状部702、704之间生长。
在操作中,如图20至图21所示,椎间植入物540被接合,以在第一构造和第二构造之间设置,使得椎体间植入物540在椎间盘空间中膨胀。椎间植入物540与仪器(未示出)接合以方便根据具体外科应用的要求致动椎间植入物540的各部件。
在第一构造中,例如在收缩构造中(图20),部件546、548以较低的轮廓定向方式与楔形件558一起设置。当根据具体外科应用的要求对椎间植入物540进行所需的定位后,如上所述,螺钉592***作以轴向移动楔形件558。当楔形件558沿箭头AA所示方向轴向平移时,楔部614、620、616、622可滑动地接合延伸部560、562。由于楔形件558的轴向平移而导致的楔形件558表面与部件546、548的可滑动接合操作使部件546相对于部件548以转动方式绕铰接部550进行枢转,使得部件546、548在第一收缩构造和第二膨胀构造(图21)之间膨胀。该构造方便了椎间植入物540的膨胀,使得前端542相对于后端544具有更大的膨胀率和膨胀量。
在一个实施例中,椎间植入物540可以通过沿图20和图21中箭头BB所示的、与第一轴向相反的第二轴向操作楔形件558,以从膨胀构造收缩到在膨胀构造和收缩构造之间的替代构造。可以设想的是,用以收缩椎体间植入物540的、楔形件58的反向轴向运动可用以重新定位椎体间植入物540或从体腔内移除椎体间植入物540。当在膨胀构造中设置椎间植入物540时,为将椎间植入物540设置为另一构造,螺钉592沿逆时针方向转动,使得楔形件558沿箭头B所示的第二相反方向轴向平移。楔形件558沿第二轴向方向进行轴向平移,部件546绕铰接部550枢转,以向着收缩构造转动。
在一个实施例中,如图22至图26所示,椎间植入物***包括类似于上述椎间植入物40和椎间植入物540的椎间植入物840以及其部件。椎间植入物840包括基底部件848,基底部件848具有构造成附连到***件或工具(未示出)的后端886,该***件或工具接合螺钉892以轴向平移楔形件858。基底部件848包括楔形前端884。当椎体间植入物840被***椎间盘空间时,基底部件848保护楔形件858和螺钉892。可以考虑的是,用以将椎体间植入物840引入或递送到椎间盘空间的力通过该***件被传递到椎体间植入物840的前端842。活塞部件846包括开口847,基底部件848包括开口849。开口847、849被构造成接收射线不透性标记件。
椎体间植入物840包括将活塞部件846连接到楔形件858的联接部件902。联接部件902具有包括槽孔906的第一端904,该槽孔906支持活塞部件846的销908。销908由槽孔906可滑动地支持以在其中移动。联接部件902具有第二端910,该第二端910由销912而与楔形件858连接。
如以上关于椎间植入物40、540所述的,当椎间植入物840膨胀到第二膨胀构造(图24)时,联接部件902具有被动构造。如本文所述,在需要椎间植入物840收缩的应用场合中,该联接部件902将活塞部件846拉到收缩位置(图26)。联接部件902方便了在膨胀构造时设置椎间植入物840,以移除或重定向椎间盘空间中的椎间植入物840。可以设想的是,联接部件902避免了在轴向平移期间移植骨和/或中间件不必要地接合和/或干涉楔形件858。楔形件858包括开口859,开口859用于减少材料,以减少医疗成像散射现象。
在一个实施例中,如图27和图28所示,椎体间植入物840可以通过使用销和通路构造而主动收缩。活塞部件846包括从延伸部860、862向内延伸的销948。销948设置在由楔形件858的相对侧壁952形成的通路950中。销948被设置用来在通路950的构造内可滑动地移动。如本文所述,当椎间植入物840收缩时,楔形件858通过轴向平移被缩回。通路950沿楔形件858选择性地导引各销,以将活塞部件846拉到收缩构造中。可以设想的是,楔形件858可以包括多个销,并且活塞部件846包括用以将活塞部件846拉到收缩构造中的多个通路。还可以设想的是,楔形件858可以包括用以在通路950中可滑动移动的燕尾形构件。
将会理解的是,可以对本文公开的实施例做各种修改。因而,以上所述内容不应解释为限制,而应解释为只是各实施方式的示例。本领域的普通技术人员会在所附权利要求的范围和精神内设想其它修改。
Claims (18)
1.一种椎间植入物,包括:
第一部件,所述第一部件包括外部组织接合表面和内表面;
第二部件,所述第二部件连接到所述第一部件并且能够从所述第一部件相对地移动,所述第二部件包括外部组织接合表面和内表面,所述第二部件包括致动件;和
第三部件,所述第三部件被设置用于接合操作,并能够相对于所述第一部件和所述第二部件移动,所述第三部件至少包括第一斜部和与所述第一斜部轴向间隔开的第二斜部,其中,所述第三部件包括第一导轨和第二导轨,所述第一导轨包括所述第一斜部和所述第二斜部,所述第二导轨包括第三斜部和第四斜部,所述第三斜部与所述第四斜部轴向间隔开,
其中,所述致动件能够与所述第三部件接合,以实现所述第三部件的轴向平移,使得所述第一斜部、所述第二斜部、所述第三斜部和所述第四斜部接合所述第一部件和所述第二部件中的一个的内表面,以使各所述部件在第一收缩构造和第二膨胀构造之间移动。
2.如权利要求1所述的椎间植入物,其特征在于,所述第一斜部具有第一高度,而所述第二斜部具有第二高度,所述第一高度大于所述第二高度。
3.如权利要求1所述的椎间植入物,其特征在于,所述第一斜部具有第一倾斜角,而所述第二斜部具有第二倾斜角,所述第一倾斜角大于所述第二倾斜角。
4.如权利要求1所述的椎间植入物,其特征在于,还包括移植骨腔,所述第一部件、所述第二部件和所述第三部件中的至少一个限定移植骨腔,所述移植骨腔被构造成在所述第一收缩构造和所述第二膨胀构造之间保持所述移植骨的体积。
5.如权利要求1所述的椎间植入物,其特征在于,所述第二部件包括设置在其后端附近的壁,所述第三部件包括在轴向平移期间绕所述壁移动的导轨部。
6.如权利要求1所述的椎间植入物,其特征在于,所述第三部件包括移植骨接收部。
7.如权利要求1所述的椎间植入物,其特征在于,所述第三部件包括移植骨接收部,并且所述第一部件和所述第二部件中的至少一个包括移植骨接收部。
8.如权利要求1所述的椎间植入物,其特征在于,所述第二部件包括设置在其后端附近的壁,所述第三部件包括在轴向平移期间在所述壁中移动的导轨部。
9.如权利要求1所述的椎间植入物,其特征在于,所述第一部件、所述第二部件和所述第三部件限定移植骨腔,所述移植骨腔限定轴向长度,当所述第一部件、所述第二部件和所述第三部件从第一收缩构造向第二膨胀构造移动时,所述轴向长度减少。
10.如权利要求1所述的椎间植入物,其特征在于,所述致动件包括在所述第二部件中形成的螺纹腔和构造成与所述第三部件接合的夹紧螺母。
11.如权利要求1所述的椎间植入物,其特征在于,所述第一斜部包括前楔形件,并且第二斜部包括后楔形件,使得所述前楔形件设置在所述第一部件的前端附近,并且所述后楔形件设置在所述第一部件的后端附近。
12.如权利要求11所述的椎间植入物,其特征在于,所述第二膨胀构造包括初级膨胀和次级膨胀,所述初级膨胀中,所述前端和所述后端膨胀量相同,所述次级膨胀中,所述前端的膨胀量大于所述后端的膨胀量。
13.如权利要求1所述的椎间植入物,其特征在于,所述第一部件的第一端可枢转地连接到所述第二部件的第一端。
14.如权利要求1所述的椎间植入物,其特征在于,还包括附连到所述第三部件和所述第一部件的第二端的可移动联接件,在各所述部件从所述第二膨胀构造移动到所述第一收缩构造期间,所述联接件将各所述部件拉到收缩定向。
15.如权利要求14所述的椎间植入物,其特征在于,所述联接件包括所述第一部件的槽孔和由所述第三部件限定的销。
16.如权利要求1所述的椎间植入物,其特征在于,所述第一斜部通过线性构件与所述第二斜部连接。
17.如权利要求1所述的椎间植入物,其特征在于,所述第一斜部包括具有第一倾斜角的第一表面和具有第二倾斜角的第二表面。
18.一种椎间植入物,包括:
活塞部件,所述活塞部件包括终板表面和以与所述终板表面相反的定向设置的内表面,所述活塞部件在前端和后端之间延伸;
基底部件,所述基底部件包括终板表面和以与所述基底部件的所述终板表面相反的定向设置的内表面,所述基底部件在前端和后端之间延伸,所述基底部件在相应的后端可枢转地连接到所述活塞部件,所述基底部件的所述后端包括螺纹腔;
螺钉,所述螺钉构造成设置在所述螺纹腔中;
楔形件,所述楔形件被设置以用于接合操作,并且能够相对于所述活塞部件和所述基底部件进行移动,所述楔形件包括具有第一高度和第一倾斜角的第一斜部以及具有第二高度和第二倾斜角的第二斜部,所述第一斜部与所述第二斜部轴向间隔开,所述楔形件包括第一导轨和第二导轨,所述第一导轨包括所述第一斜部和所述第二斜部,所述第二导轨包括第三斜部和第四斜部,所述第三斜部与所述第三斜部轴向间隔开,
其中,所述螺钉能够与所述楔形件接合,以实现所述楔形件的轴向平移,使得所述第一斜部、所述第二斜部、所述第三斜部和所述第四斜部接合所述活塞部件的所述内表面,以使所述活塞部件相对于所述基底部件枢转,使得各所述部件在第一收缩构造和第二膨胀构造之间膨胀。
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US13/329,845 | 2011-12-19 | ||
PCT/US2012/063259 WO2013095789A1 (en) | 2011-12-19 | 2012-11-02 | Expandable interbody implant and methods of use |
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AU2012355894B2 (en) | 2015-08-27 |
EP3403621A1 (en) | 2018-11-21 |
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EP3403621B1 (en) | 2021-12-29 |
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WO2013095789A1 (en) | 2013-06-27 |
JP2017131679A (ja) | 2017-08-03 |
EP2793760B1 (en) | 2018-08-08 |
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