CN102973828B - Compound propolis composition for treating poultry rabbit coccidiosis and preparation method thereof - Google Patents
Compound propolis composition for treating poultry rabbit coccidiosis and preparation method thereof Download PDFInfo
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- CN102973828B CN102973828B CN201210516194.1A CN201210516194A CN102973828B CN 102973828 B CN102973828 B CN 102973828B CN 201210516194 A CN201210516194 A CN 201210516194A CN 102973828 B CN102973828 B CN 102973828B
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Abstract
The invention relates to a compound propolis composition for treating poultry rabbit coccidiosis. The compound propolis composition is prepared by the mixing the following components by weight part: 15-35 parts of propolis, 20-35 parts of the fruit of rangoon creeper, 20-35 parts of areca-nut, 15-35 parts of radix bupleuri, 15-35 parts of lalang grass rhizome, 15-25 parts of coptis chinensis, 15-25 parts of amur cork tree bark and 15-45 parts of flower of poplar. The compound propolis composition has the beneficial effects of reasonable formula, simple preparation, no pollution, no toxic or side effect and no drug residue due to pure traditional Chinese medicine, superfine grinding, high bioavailability, extremely obviously curative effect and special effect on the treatment of poultry rabbit coccidiosis through clinical proving.
Description
Technical field
The present invention relates to a kind of compound bee-glue composition for the treatment of Rabbit Coccidiosis and preparation method thereof, belong to field of animal, particularly a kind of compound bee-glue composition and preparation method thereof being specifically designed to treatment Rabbit Coccidiosis.
Background technology
Rabbit Coccidiosis is that a kind of common transmittable the most serious to rabbit keeping harm caused by coccidiosis is sick, this disease throughout the year all can eruption and prevalence, clinically to suffer from diarrhoea, to arrange red feces for feature, main on pathology is feature with intestinal bleeding, and mortality rate can up to 60%, and the rabbit growth promoter of recovering is obstructed, the price of deed declines, Abwehrkraft des Koepers reduces, and easily suffers from Other diseases, very large to the harm of rabbit.
The pathogen of primary disease is coccidiosis, belongs to protozoa, has 9 kinds.This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antibacterials and coccidiostat, as oxytetracycline, sulfa drugs, Salinomycin, nicarbazine, diclazuril etc.; Due to the prolonged and repeated use of these medicines, cause this pathogenic microorganism to create drug resistance to medicine, reduce curative effect, and drug residue in animal body, its meat does not reach nuisanceless requirement, have impact on the outlet of livestock products and the health of people.
Therefore research and develop a kind of treat Rabbit Coccidiosis and have no side effect, the specific medicament of drug residue free is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, prepare simple, successful, the compound bee-glue composition of effectively treating Rabbit Coccidiosis and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Rabbit Coccidiosis, by following component by weight mixed preparing form: propolis 15-35 part, Fructus Quisqualis 20-35 part, Semen Arecae 20-35 part, Radix Bupleuri 15-35 part, Rhizoma Imperatae 15-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-25 part, flower of poplar 15-45 part.
Described various component optimum ratio amount is: propolis 25 parts, Fructus Quisqualis 30 parts, Semen Arecae 30 parts, Radix Bupleuri 25 parts, Rhizoma Imperatae 25 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 20 parts, flower of poplar 30 parts.
Treat a preparation method for the compound bee-glue composition of Rabbit Coccidiosis, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Fructus Quisqualis 20-35 part, Semen Arecae 20-35 part, Radix Bupleuri 15-35 part by weight, mix 5-10 minute to even;
(3) take Rhizoma Imperatae 15-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-25 part, flower of poplar 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function etc. of hemostasis protozoacide, protection gastrointestinal mucosa.
Fructus Quisqualis: sweet, warm, returns stomach, spleen channel, has the function of killing insect and eliminating accumulation; Cure mainly ascariasis, abdominal pain due to worm stagnation, enterobiasis etc.
Semen Arecae: bitter, pungent, warm, returns stomach, large intestine channel, has the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Radix Bupleuri: pungent, bitter, be slightly cold, returns liver, gallbladder, lung meridian, has and deliver and inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI function; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea etc.
Rhizoma Imperatae: sweet, cold, returns lung, stomach, urinary bladder channel, has the function of clearing away heat and promoting diuresis, cooling blood for hemostasis; Cure mainly epistaxis, hematuria, pyretic stranguria, edema etc.
Rhizoma Coptidis: bitter, cold, returns liver, the heart, spleen, stomach, gallbladder, large intestine channel, has the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.
Cortex Phellodendri: bitter, cold, returns kidney, urinary bladder channel, has the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Flower of poplar: bitter, cold, returns liver, gallbladder, large intestine channel, has the function of heat-clearing and toxic substances removing, removing dampness antidiarrheal; Cure mainly damp-heat diarrhea, young stock is had loose bowels.
All taste Chinese medicine is according to tcm theory compatible combination above, for the pathogenic microorganism of Rabbit Coccidiosis and clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, and no drug residue has no side effect; Cost is low, draws materials wide; Micronizing, bioavailability is high, curative effect highly significant.Adopt pharmacology of Chinese materia medica method, optimize this eight kinds of medicines, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, have specially good effect to treatment Rabbit Coccidiosis and have no side effect, drug residue and drug resistance, and make rabbit product reach nuisanceless requirement, meet the export standard of rabbit product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of Rabbit Coccidiosis and preparation method thereof: carry out as follows:
(every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 150 parts, Fructus Quisqualis 200 parts, Semen Arecae 200 parts, Radix Bupleuri 150 parts by weight, mix 5-10 minute to even;
(3) take Rhizoma Imperatae 150 parts, Rhizoma Coptidis 150 parts, Cortex Phellodendri 150 parts, flower of poplar 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of Rabbit Coccidiosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 250 parts, Fructus Quisqualis 300 parts, Semen Arecae 300 parts, Radix Bupleuri 250 parts by weight, mix 5-10 minute to even;
(3) take Rhizoma Imperatae 250 parts, Rhizoma Coptidis 200 parts, Cortex Phellodendri 200 parts, flower of poplar 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of Rabbit Coccidiosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 350 parts, Fructus Quisqualis 350 parts, Semen Arecae 350 parts, Radix Bupleuri 350 parts by weight, mix 5-10 minute to even;
(3) take Rhizoma Imperatae 350 parts, Rhizoma Coptidis 250 parts, Cortex Phellodendri 250 parts, flower of poplar 450 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 50-60 age in days, and Laboratory Diagnosed is the carnivorous rabbit of Rabbit Coccidiosis, is isolated and raises separately, complete feed of feeding, and be divided into 3 groups at random, and often organize 60,3 groups of feeding environments are identical, and test period is 5 days; Blank group is left intact, and drug control group " rabbit coccidia powder " by specification uses treatment; Chinese medicine composition group of the present invention by product of the present invention (compositions obtained by the embodiment of the present invention 1) the ill rabbit of feeding etc., day dose be: by every Kg body weight 2-3g, spice is fed, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the situation that product of the present invention and other medicines treat Rabbit Coccidiosis contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 16.7 | 66.6 | 16.7 |
| II | Rabbit coccidia powder group | 10.0 | 81.7 | 8.3 |
| III | Chinese medicine composition of the present invention | 6.6 | 88.4 | 5.0 |
This clinical effectiveness statistical analysis, present composition treatment group is significant difference (P < 0.05) compared with rabbit coccidia powder group.
Safety testing:
Choose the healthy carnivorous rabbit 30 of 25 ages in days, 5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 1 are fed 5 days, during medication, healthy carnivorous rabbit is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of compound bee-glue composition of this treatment Rabbit Coccidiosis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for Rabbit Coccidiosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Fructus Quisqualis 20-35 part, Semen Arecae 20-35 part, Radix Bupleuri 15-35 part, Rhizoma Imperatae 15-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-25 part, flower of poplar 15-45 part.
2. the compound bee-glue composition for the treatment of Rabbit Coccidiosis according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, Fructus Quisqualis 30 parts, Semen Arecae 30 parts, Radix Bupleuri 25 parts, Rhizoma Imperatae 25 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 20 parts, flower of poplar 30 parts.
3. a preparation method for the compound bee-glue composition for the treatment of Rabbit Coccidiosis according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Fructus Quisqualis 20-35 part, Semen Arecae 20-35 part, Radix Bupleuri 15-35 part by weight, mix 5-10 minute to even;
(3) take Rhizoma Imperatae 15-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-25 part, flower of poplar 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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| CN201210516194.1A CN102973828B (en) | 2012-11-22 | 2012-11-22 | Compound propolis composition for treating poultry rabbit coccidiosis and preparation method thereof |
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| CN201210516194.1A CN102973828B (en) | 2012-11-22 | 2012-11-22 | Compound propolis composition for treating poultry rabbit coccidiosis and preparation method thereof |
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| CN102973828B true CN102973828B (en) | 2014-12-31 |
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| CN108148761A (en) * | 2017-12-31 | 2018-06-12 | 天津赫莱恩特生物科技有限公司 | A kind of composition for improving Eimeria Tenella egg capsule yield and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102274318A (en) * | 2011-07-15 | 2011-12-14 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry coccidiosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102274318A (en) * | 2011-07-15 | 2011-12-14 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating poultry coccidiosis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中草药防治鸡、兔球虫病的研究进展;卢福庄等;《浙江农业学报》;20071231;第19卷(第3期);253～257 * |
| 陈桂先.无.《兽医临床用药速览》.化学工业出版社,2011,(第1版),248. * |
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