CN104940498A - Medicine for treating colonic ulcer and preparation method thereof - Google Patents
Medicine for treating colonic ulcer and preparation method thereof Download PDFInfo
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- CN104940498A CN104940498A CN201510414165.8A CN201510414165A CN104940498A CN 104940498 A CN104940498 A CN 104940498A CN 201510414165 A CN201510414165 A CN 201510414165A CN 104940498 A CN104940498 A CN 104940498A
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Abstract
The invention discloses a medicine for treating a colonic ulcer and a preparation method thereof. The medicine for treating the colonic ulcer is mainly prepared by patrinia scaniosaefolia, agastache rugosus, poria cocos, white paeony roots, hyacinth beans, common vladimiria roots, betelnut peels, coptidis rhizome, myrrh, liquorice and nutmeg in certain weight proportions. The medicine for treating the colonic ulcer achieves the functions of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting the circulation of qi and guiding stagnation, and reinforcing deficiency and strengthening the body resistance, in use for treating the colonic ulcer, the medicine for treating the colonic ulcer produces an instant effect, the good therapeutic effect is achieved, and no relapse occurs.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of colonic ulcer and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Colonic ulcer is that one is confined to mucous membrane of colon and submucosal inflammation, and multidigit, in sigmoid colon and rectum, also may extend to descending colon, even whole colon.Pathology is very long, normal recurrent exerbation.Primary disease sees any age, but 20-30 year is the most common.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating colonic ulcer in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment colonic ulcer, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment colonic ulcer.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Herba Patriniae, Herba Pogostemonis, Poria, the Radix Paeoniae Alba, Seem Lablab Album, the Radix Aucklandiae, Pericarpium Arecae, Rhizoma Coptidis, Myrrha, Radix Glycyrrhizae, Semen Myristicae, the Radix Angelicae Dahuricae, Flos Lonicerae, Fructus Schisandrae Chinensis medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat colonic ulcer.Wherein, Herba Patriniae is selected to be that flat, enter liver, stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, controls acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies because its nature and flavor are bitter.Herba Pogostemonis is selected to be that tepor, enters lung, spleen, stomach warp, have fast gas because its nature and flavor are pungent, and in, ward off dirty, the function of damp eliminating, cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Seem Lablab Album to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, have spleen invigorating and in, the function of removing dampness of relieving summer heat, control heat-damp in summer and vomit and diarrhoea, insufficiency of the spleen vomiting, lack of appetite chronic diarrhea, water retention is quenched one's thirst, leucorrhea with red and white discharge, infantile malnutrition.Select the Radix Aucklandiae to be that temperature, enters lung, liver, spleen channel, have promoting the circulation of QI to relieve pain, the function of warming middle-JIAO for easing the stomach, control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain because its nature and flavor are worked hard, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Myrrha is selected to be that flat, enter Liver Channel, have loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and fall damage, incised wound, muscles and bones, trusted subordinate all Tong ， mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye because its nature and flavor are bitter.Radix Glycyrrhizae is selected to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription; Process use, control taste lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus ， Jing Epilepsy; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, carbuncle subcutaneous ulcer skin infection, separates poison of drug and alimentary toxicosis.Select meat bean Kou to be that temperature, enters spleen, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, help digestion, Gu the function of intestinal, control trusted subordinate's distending pain, diarrhea of deficiency type cold-dysentery because its nature and flavor are pungent, vomiting, dyspepsia does not disappear.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid;
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Herba Patriniae 20-25 gram, Herba Pogostemonis 8-13 gram, Poria 9-12 gram, Radix Paeoniae Alba 7-12 gram, Seem Lablab Album 8-15 gram, Radix Aucklandiae 5-8 gram, Pericarpium Arecae 7-13 gram, Rhizoma Coptidis 8-15 gram, Myrrha 9-15 gram, Radix Glycyrrhizae 7-11 gram, Semen Myristicae 4-10 gram, Radix Angelicae Dahuricae 5-8 gram, Flos Lonicerae 20-25 gram, Fructus Schisandrae Chinensis 9-14 gram.
Be preferably:
Herba Patriniae 25 grams, Herba Pogostemonis 10 grams, 10 grams, Poria, the Radix Paeoniae Alba 10 grams, 10 grams, Seem Lablab Album, the Radix Aucklandiae 6 grams, Pericarpium Arecae 10 grams, Rhizoma Coptidis 10 grams, Myrrha 10 grams, 10 grams, Radix Glycyrrhizae, Semen Myristicae 6 grams, the Radix Angelicae Dahuricae 6 grams, Flos Lonicerae 25 grams, Fructus Schisandrae Chinensis 10 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;
2, Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;
3, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
4, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
5, Seem Lablab Album: get clean Seem Lablab Album, put in pot and fry to slightly focal spot, taking-up cools;
6, the Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
7, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
8, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
9, Myrrha: pick decontamination, breaks into fragment;
10, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
11, meat bean Kou: get crude drug, removing impurity, the used time smashs to pieces;
12, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
13, Flos Lonicerae: sieve removes silt, picks clean impurity;
14, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
Two, prepare
1, by the Herba Patriniae of described weight, Herba Pogostemonis, Poria, the Radix Paeoniae Alba, Seem Lablab Album, the Radix Aucklandiae, Pericarpium Arecae, Rhizoma Coptidis, Myrrha, Radix Glycyrrhizae, Semen Myristicae, the Radix Angelicae Dahuricae, Flos Lonicerae, Fructus Schisandrae Chinensis is put into decocting container and to be added water 6 times amount, soaks after 100 minutes, and intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.
2, add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring, 2 doses are divided into take.
In prescription, Herba Patriniae has heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, is monarch drug; The Radix Angelicae Dahuricae dispels the wind, dampness, detumescence, pain relieving; Semen Myristicae has warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, helps digestion, Gu the function of intestinal, the two is ministerial drug, and three taste medicines play warming the middle warmer and descending qi, heat-clearing and toxic substances removing jointly, evacuation of pus removing blood stasis with potent drugs, reducing swelling and alleviating pain, Gu the effect of intestinal, treatment colonic ulcer effect is comprehensive, and with evacuation of pus removing blood stasis with potent drugs, reducing swelling and alleviating pain, can effect a permanent cure Gu intestinal is master, Myrrha has loose blood blood stasis removing, and the function of subduing swelling and relieving pain is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription is for making medicine, and all medicines take stopgap measures with being left.
Medicine of the present invention has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, circulation of qi promoting intestinal stasis relieving, and the function of tonify deficiency righting, is used for the treatment of colonic ulcer, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept colonic ulcer out-patient totally 30 examples for medical treatment.
2, diagnostic criteria
Classical symptom is stomachache and diarrhoea, and stomachache is positioned at left lower quadrant, dull pain, angor, alleviates after an action of the bowels.Suffer from diarrhoea the most common with mucopurulent bloody stool, every day for several times to 10 times not etc., often accompany tenesmus.Still there are Nausea and vomiting, inappetence.Light-duty patient often has left lower quadrant or full abdominal pressure pain to accompany borborygmus hyperfunction.Heavy and fulminant type patient can have tension of abdominal muscle, rebound tenderness, maybe can touch sigmoid colon and descending colon that spasm or intestinal wall thicken.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: colonic ulcer transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient's stomachache, diarrhoea, phenomenon of feeling sick alleviate, and colonic ulcer symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy colonic ulcer patient 30 example of the present invention, effective 24 examples of result, obvious effective rate is 80%, and take a turn for the better 4 examples, and improvement rate is 13.33%, and invalid 2 examples, total effective rate is 93.33%.
Claims (3)
1. treat a medicine for colonic ulcer, it is characterized in that: it is made up of the crude drug in following weight range:
Herba Patriniae 20-25 gram, Herba Pogostemonis 8-13 gram, Poria 9-12 gram, Radix Paeoniae Alba 7-12 gram, Seem Lablab Album 8-15 gram, Radix Aucklandiae 5-8 gram, Pericarpium Arecae 7-13 gram, Rhizoma Coptidis 8-15 gram, Myrrha 9-15 gram, Radix Glycyrrhizae 7-11 gram, Semen Myristicae 4-10 gram, Radix Angelicae Dahuricae 5-8 gram, Flos Lonicerae 20-25 gram, Fructus Schisandrae Chinensis 9-14 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Patriniae 25 grams, Herba Pogostemonis 10 grams, 10 grams, Poria, the Radix Paeoniae Alba 10 grams, 10 grams, Seem Lablab Album, the Radix Aucklandiae 6 grams, Pericarpium Arecae 10 grams, Rhizoma Coptidis 10 grams, Myrrha 10 grams, 10 grams, Radix Glycyrrhizae, Semen Myristicae 6 grams, the Radix Angelicae Dahuricae 6 grams, Flos Lonicerae 25 grams, Fructus Schisandrae Chinensis 10 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Herba Patriniae: get crude drug, removing impurity, with Water spray, slightly dries in the air, and cutting is dry;
(2) Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;
(3) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(4) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(5) Seem Lablab Album: get clean Seem Lablab Album, put in pot and fry to slightly focal spot, taking-up cools;
(6) Radix Aucklandiae: put by crude drug in whole in clear water and clean, pull out, moistening makes soft for 12-24 hours, section, dries;
(7) Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
(8) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;
(9) Myrrha: pick decontamination, breaks into fragment;
(10) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(11) meat bean Kou: get crude drug, removing impurity, the used time smashs to pieces;
(12) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;
(13) Flos Lonicerae: sieve removes silt, picks clean impurity;
(14) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(2) prepare
(1) Herba Patriniae of described weight, Herba Pogostemonis, Poria, the Radix Paeoniae Alba, Seem Lablab Album, the Radix Aucklandiae, Pericarpium Arecae, Rhizoma Coptidis, Myrrha, Radix Glycyrrhizae, Semen Myristicae, the Radix Angelicae Dahuricae, Flos Lonicerae, Fructus Schisandrae Chinensis are put into decocting container to add water 6 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;
(2) add water the medicinal residues of filtration 5 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;
(3) by twice decoction liquor mixing and stirring, 2 doses are divided into take.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582791A (en) * | 2017-10-29 | 2018-01-16 | 杨小丽 | A kind of medicine for treating amenorrhoea and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721224A (en) * | 2013-12-14 | 2014-04-16 | 郑明立 | Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721224A (en) * | 2013-12-14 | 2014-04-16 | 郑明立 | Medicine for treating chronic nonspecific ulcerative colitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨思澍: "《中国现代名医验方荟海》", 29 February 1996, 湖北科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582791A (en) * | 2017-10-29 | 2018-01-16 | 杨小丽 | A kind of medicine for treating amenorrhoea and preparation method thereof |
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Application publication date: 20150930 |