CN103749975B - 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute - Google Patents
2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute Download PDFInfo
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- CN103749975B CN103749975B CN201310738000.7A CN201310738000A CN103749975B CN 103749975 B CN103749975 B CN 103749975B CN 201310738000 A CN201310738000 A CN 201310738000A CN 103749975 B CN103749975 B CN 103749975B
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- zinc
- hydroxybenzoic acid
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- high dose
- acid zinc
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- HRCLRELMHACPQA-UHFFFAOYSA-N O=C1ONOc2ccccc12 Chemical compound O=C1ONOc2ccccc12 HRCLRELMHACPQA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention provides the application of 2 hydroxybenzoic acid zinc as feeding high dose zinc oxide substitute.The present invention demonstrates 2 hydroxybenzoic acid zinc by series of experiments and in pig feed, applies the consumption that can reduce nearly 80% zinc oxide reach identical production performance, significantly can reduce the application of zinc in animal husbandry, production cost can be reduced, reduce the toxic and side effect of high zinc, and reduce environmental pollution, have broad application prospects.
Description
Technical field:
The invention belongs to livestock and poultry cultivation field, be specifically related to the application of 2 hydroxybenzoic acid zinc as feeding high dose zinc oxide substitute.
Background technology:
Zinc is one of required trace element of animal.After adding from the high dose wean pig feed of Late Cambrian high dose zinc oxide at the beginning of the 1990s age and can reduce diarrhea rate, improving the effects such as daily gain, generally apply at global feedstuff industry and come.Meanwhile, high dose zinc oxide is applied the Heavy-Metal-Contaminated Environments problem brought and is also paid attention to gradually.From in recent years, European Union has forbidden high dose zinc oxide.Although, China's wean pig feed feed allows the zinc using 2250ppm, but this is makeshift, can reach novel efficient, the safe feeding high dose zinc oxide substitute products that the equal Antidiarrheic effect of high dose zinc oxide ensures that heavy metal free pollutes simultaneously is needed for Modern Animal Husbandry development.
Summary of the invention:
The object of this invention is to provide the application of 2 hydroxybenzoic acid zinc as feeding high dose zinc oxide substitute.
The present invention found through experiments, and 350ppm2-hydroxybenzoic acid zinc can reach the improvement of 1000ppmZnO to test pig production performance.As can be seen here, of the present invention can when zinc ion low dosage using 2 hydroxybenzoic acid zinc as additive, its growth promotion performance reaches the level using zinc oxide as additive zinc ion high dose.
2 hydroxybenzoic acid zinc of the present invention can be applied in feed addictive as feeding high dose zinc oxide substitute, plays anti diar rhea, somatotrophic effect, i.e. the application of 2 hydroxybenzoic acid zinc in preparation animal anti diar rhea, growth accelerator.
Therefore, the invention provides the application of 2 hydroxybenzoic acid zinc as feeding high dose zinc oxide substitute.
Described 2 hydroxybenzoic acid zinc is the inner complex salt of 2 hydroxybenzoic acid and zinc mol ratio 1:1.
Described animal is preferably pig.
Described 2 hydroxybenzoic acid zinc, its additive capacity in animal feed is 100 ~ 3000ppm, and preferred dose is 200 ~ 1000ppm.
Described animal feed is preferably perfect compound feed.
The present invention demonstrates 2 hydroxybenzoic acid zinc by series of experiments in pig feed, applies the production performance that the consumption that can reduce nearly 80%ZnO reaches identical, significantly can reduce the application of zinc in animal husbandry, production cost can be reduced, reduce the toxic and side effect of high zinc, and reduce environmental pollution, have broad application prospects.
Detailed description of the invention:
Following examples further illustrate of the present invention, instead of limitation of the present invention.
The synthesis of embodiment 1:2-hydroxybenzoic acid zinc
Take 80.0g2-hydroxybenzoic acid sodium and 20.0g NaOH is dissolved in 800ml water, after stirring and dissolving, be settled to 1000ml.Separately take 144.0g white vitriol to add water after stirring and dissolving and be settled to 1000ml.Slowly pour solution of zinc sulfate into 2 hydroxybenzoic acid sodium/sodium hydroxide solution, limit edged stirs, and application of sample terminates rear continuation stirring reaction 30min.After reaction terminates, reactant liquor suction filtration is washed with water three times (using water 2000ml) at every turn, the drying of filter cake reduced vacuum.Obtain product 102.5g altogether.
Get product and carry out free water and crystallization water analysis, free water content 5.1%.The content 97.27g of 2 hydroxybenzoic acid zinc in product, reaction yield 96.26%.
After getting product 0.10g 100ml0.1M HCl dissolving, measure the content of 2 hydroxybenzoic acid in solution by HPLC method, measure the content of Zn-ef ficiency in solution simultaneously with atom absorption method.Result zinc ion concentration is 0.307mg/ml, and the content of 2 hydroxybenzoic acid is 0.642mg/ml, and in 2 hydroxybenzoic acid zinc product, the molecule mol ratio of zinc ion and 2 hydroxybenzoic acid is 1:1, and namely the molecular formula of 2 hydroxybenzoic acid zinc is C
7h
4o
3zn, molecular weight is 201.1.Structural formula is such as formula one.
Embodiment 2: the effect of various dose 2 hydroxybenzoic acid zinc in wean pig feed
The wean pig of 108 initial average weight 7.5kg of 28 age in days, the DLY ternary that body weight is close mix lean meat species piggy as table 1 points 8 groups, often organize 12.Each group add the 2 hydroxybenzoic acid zinc compound of various dose in not containing the creep feed of high zinc after, free choice feeding and drinking-water, add up the weightening finish of each test group test pig in 10 days and the price of deed and diarrhea rate.Result is as shown in table 2, and as can be seen from Table 2, the 2 hydroxybenzoic acid zinc (in compound, lower same) of 350-1500ppm all can obviously reduce test pig diarrhea rate, and has obvious dosage effect to the improvement of production performance.350ppm2-hydroxybenzoic acid zinc can reach the improvement of 1000ppmZnO to test pig production performance.
2 hydroxybenzoic acid zinc, C
7h
4o
3zn, molecular weight is that 201.1, molecular formula contains a zinc ion;
Zinc oxide, ZnO, molecular weight 81, a molecular formula contains a zinc ion.
Table 1 various dose 2 hydroxybenzoic acid zinc is to the growth-promoting effect test grouping of pork pig
*: the concentration of additive is in compound, lower same ,-: represent and do not add any zinc compound, lower same.
Table 2 various dose 2 hydroxybenzoic acid zinc is to the growth-promoting effect result of the test of wean pig
Group | Size of animal | Average daily ingestion amount g | Average daily gain (g) | Feedstuff-meat ratio | Diarrhea rate (%) |
1 | 12 | 270 | 166.7 | 1.62 | 48.2 |
2 | 12 | 335 | 237.6 | 1.41 | 19.8 |
3 | 12 | 332 | 232.2 | 1.43 | 22.1 |
4 | 12 | 312 | 205.3 | 1.52 | 29.3 |
5 | 12 | 296 | 188.5 | 1.57 | 34.8 |
6 | 12 | 293 | 185.4 | 1.58 | 33.7 |
7 | 12 | 313 | 203.2 | 1.54 | 25.2 |
8 | 12 | 273 | 165.4 | 1.65 | 45.5 |
9 | 12 | 253 | 148 | 1.71 | 27.5 |
Claims (2)
1.2-hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute in preparation animal anti diar rhea, growth accelerator;
Described animal is pig;
Described 2 hydroxybenzoic acid zinc, its additive capacity in feed for weaned is 100 ~ 3000ppm, substitutes high dose ZnO;
Described 2 hydroxybenzoic acid zinc, its structural formula such as formula shown in one,
2. application according to claim 1, is characterized in that, described 2 hydroxybenzoic acid zinc, and its additive capacity in animal feed is 200 ~ 1000ppm.
Priority Applications (2)
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CN201310738000.7A CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
PCT/CN2014/070584 WO2015096229A1 (en) | 2013-12-26 | 2014-01-14 | Application of zinc 2-hydroxybenzoate as substitute high-dose zinc oxide for use in feed |
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CN201310738000.7A CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
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CN103749975A CN103749975A (en) | 2014-04-30 |
CN103749975B true CN103749975B (en) | 2015-08-19 |
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CN201310738000.7A Active CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
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WO (1) | WO2015096229A1 (en) |
Families Citing this family (4)
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CN104041669B (en) * | 2014-05-23 | 2017-06-23 | 广州英赛特生物技术有限公司 | Capric acid zinc as animal feed additive application |
CN108617856A (en) * | 2018-03-14 | 2018-10-09 | 广州英赛特生物技术有限公司 | Application of the zinc benzoate in preparing animal feed additive |
EP3979814A1 (en) * | 2019-06-07 | 2022-04-13 | DSM IP Assets B.V. | Use of benzoic acid and essential oil compounds for improving growth performance |
WO2020243975A1 (en) * | 2019-06-07 | 2020-12-10 | Dsm Ip Assets B.V. | Use of nutraceutical composition in animal feed |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1658768A (en) * | 2002-05-14 | 2005-08-24 | 阿克佐诺贝尔公司 | Method for reducing methane production emanating from the digestive activities of an animal |
CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
CN101720856A (en) * | 2008-10-21 | 2010-06-09 | 刘方圆 | Additive of piglet disease-resistant concentrated feed |
CN101946897A (en) * | 2010-08-11 | 2011-01-19 | 绵阳崴尼达化工有限公司 | Method for producing water-soluble chromium picolinate |
Family Cites Families (2)
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CN102265987B (en) * | 2011-08-25 | 2013-06-26 | 山东新希望六和集团有限公司 | Mixed feed for weaned pigling and preparation method thereof |
CN102640879B (en) * | 2012-05-24 | 2013-06-26 | 山东新希望六和集团有限公司 | Completely cured suckling pig compound feed and preparation method thereof |
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- 2013-12-26 CN CN201310738000.7A patent/CN103749975B/en active Active
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- 2014-01-14 WO PCT/CN2014/070584 patent/WO2015096229A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1658768A (en) * | 2002-05-14 | 2005-08-24 | 阿克佐诺贝尔公司 | Method for reducing methane production emanating from the digestive activities of an animal |
CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
CN101720856A (en) * | 2008-10-21 | 2010-06-09 | 刘方圆 | Additive of piglet disease-resistant concentrated feed |
CN101946897A (en) * | 2010-08-11 | 2011-01-19 | 绵阳崴尼达化工有限公司 | Method for producing water-soluble chromium picolinate |
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WO2015096229A1 (en) | 2015-07-02 |
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Effective date of registration: 20161228 Address after: 512400 Guangdong city of Shaoguan province Nanxiong City Abas Industrial Park West No. 8 building three peace Patentee after: Nanxiong yingsaite Fine Chemical Technology Co Ltd Address before: High tech Industrial Development Zone, Guangzhou City, Guangdong province 510530 Science City skim Springs Road No. 3, Guangzhou international business incubator D District No. 415 Patentee before: Guangzhou Insighter Biotechnology Co., Ltd. |