CN103749975A - Application of zinc 2-hydroxybenzoate as high-dose zinc oxide alternative for feed - Google Patents
Application of zinc 2-hydroxybenzoate as high-dose zinc oxide alternative for feed Download PDFInfo
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- CN103749975A CN103749975A CN201310738000.7A CN201310738000A CN103749975A CN 103749975 A CN103749975 A CN 103749975A CN 201310738000 A CN201310738000 A CN 201310738000A CN 103749975 A CN103749975 A CN 103749975A
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- Prior art keywords
- zinc
- hydroxybenzoic acid
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- feed
- zinc oxide
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention provides an application of zinc 2-hydroxybenzoate as a high-dose zinc oxide alternative for feeds. A series of experiments show that when zinc 2-hydroxybenzoate is used in pig feeds, the use amount of zinc oxide can be reduced by nearly 80% but the same production performance can be achieved, so that the application of zinc in animal husbandry is remarkably reduced, the production cost is lowered, the toxic and side effect of high zinc is reduced, the environment pollution is reduced, and a wide application prospect is achieved.
Description
Technical field:
The invention belongs to livestock and poultry cultivation field, be specifically related to 2 hydroxybenzoic acid zinc as the application of feeding high dose zinc oxide substitute.
Background technology:
Zinc is one of essential trace element of animal.After finding first that high dose zinc oxide high dose wean pig feed adds and can reduce diarrhea rate, improves daily gain texts at the beginning of the 1990s age, at global feedstuff industry, generally apply and come.Meanwhile, the Heavy-Metal-Contaminated Environments problem that the application of high dose zinc oxide brings is also paid attention to gradually.From in recent years, European Union has forbidden high dose zinc oxide.Although, China's wean pig feed feed allows to use the zinc of 2250ppm, but this is makeshift, can reach novel efficient, the safe feeding high dose zinc oxide substitute products that the equal Antidiarrheic effect of high dose zinc oxide guarantees that heavy metal free pollutes is simultaneously that Modern Animal Husbandry development is required.
Summary of the invention:
The object of this invention is to provide 2 hydroxybenzoic acid zinc as the application of feeding high dose zinc oxide substitute.
The present invention found through experiments, and 350ppm2-hydroxybenzoic acid zinc can reach the improvement of 1000ppmZnO to test pig production performance.As can be seen here, of the present invention using 2 hydroxybenzoic acid zinc can be the zinc ion low dosage in the situation that as additive, its growth promotion performance reaches usings the level of zinc oxide as additive zinc ion high dose.
2 hydroxybenzoic acid zinc of the present invention can be used as feeding high dose zinc oxide substitute and is applied in feed addictive, plays anti diar rhea, somatotrophic effect, i.e. the application of 2 hydroxybenzoic acid zinc in preparation animal anti diar rhea, growth accelerator.
Therefore, the invention provides 2 hydroxybenzoic acid zinc as the application of feeding high dose zinc oxide substitute.
Described 2 hydroxybenzoic acid zinc is the inner complex salt of 2 hydroxybenzoic acid and zinc mol ratio 1:1.
Described animal is preferably pig.
Described 2 hydroxybenzoic acid zinc, its additive capacity in animal feed is 100～3000ppm, preferred dose is 200～1000ppm.
Described animal feed is preferably perfect compound feed.
The present invention has proved that by series of experiments 2 hydroxybenzoic acid zinc applies the consumption that can reduce nearly 80%ZnO and reach identical production performance in pig feed, can significantly reduce the application of zinc in animal husbandry, can reduce production costs, reduce the toxic and side effect of high zinc, and reduce environmental pollution, have broad application prospects.
The specific embodiment:
Following examples are to further illustrate of the present invention, rather than limitation of the present invention.
Synthesizing of embodiment 1:2-hydroxybenzoic acid zinc
Take 80.0g2-hydroxybenzoic acid sodium and 20.0g NaOH and be dissolved in 800ml water, after stirring and dissolving, be settled to 1000ml.Separately take after 144.0g white vitriol adds water stirring and dissolving and be settled to 1000ml.Slowly solution of zinc sulfate is poured into 2 hydroxybenzoic acid sodium/sodium hydroxide solution, limit edged stirs, and application of sample finishes rear continuation stirring reaction 30min.After reaction finishes, by reactant liquor suction filtration and wash (each water 2000ml) with water three times, filter cake reduced vacuum is dry.Obtain altogether product 102.5g.
Get product and carry out free water and crystallization water analysis, free water content 5.1%.The content 97.27g of 2 hydroxybenzoic acid zinc in product, reaction yield 96.26%.
Get product 0.10g with after 100ml0.1M HCl dissolving, by HPLC method, measure the content of 2 hydroxybenzoic acid in solution, with atom absorption method, measure the content of zinc element in solution simultaneously.Result zinc ion concentration is 0.307mg/ml, and the content of 2 hydroxybenzoic acid is 0.642mg/ml, and in 2 hydroxybenzoic acid zinc product, the molecule mol ratio of zinc ion and 2 hydroxybenzoic acid is 1:1, and the molecular formula of 2 hydroxybenzoic acid zinc is C
7h
4o
3zn, molecular weight is 201.1.Structural formula is suc as formula one.
Embodiment 2: the effect of various dose 2 hydroxybenzoic acid zinc in wean pig feed
The assorted lean meat species piggy of DLY ternary that wean pig, the body weight of 108 initial average weight 7.5kg of 28 age in days are close is as table 1 minutes 8 groups, 12 every group.Each group is not being added after the 2 hydroxybenzoic acid zinc compound of various dose containing in the creep feed of high zinc, and free choice feeding and drinking-water, add up weightening finish and the price of deed and the diarrhea rate of each test group test pig in 10 days.Result is as shown in table 2, and as can be seen from Table 2, the 2 hydroxybenzoic acid zinc of 350-1500ppm (in compound, lower same) all can obviously reduce test pig diarrhea rate, and the improvement of production performance is had to obvious dosage effect.350ppm2-hydroxybenzoic acid zinc can reach the improvement of 1000ppmZnO to test pig production performance.
2 hydroxybenzoic acid zinc, C
7h
4o
3zn, molecular weight is that 201.1, one molecular formula contain a zinc ion;
Zinc oxide, ZnO, 81, one molecular formula of molecular weight contain a zinc ion.
The growth-promoting effect test grouping of table 1 various dose 2 hydroxybenzoic acid zinc to pork pig
*: the concentration of additive is in compound, lower same ,-: represent not add any zinc compound, lower same.
The growth-promoting effect result of the test of table 2 various dose 2 hydroxybenzoic acid zinc to wean pig
| Group | Size of animal | Average daily ingestion amount g | Average daily gain (g) | Feedstuff-meat ratio | Diarrhea rate (%) |
| 1 | 12 | 270 | 166.7 | 1.62 | 48.2 |
| 2 | 12 | 335 | 237.6 | 1.41 | 19.8 |
| 3 | 12 | 332 | 232.2 | 1.43 | 22.1 |
| 4 | 12 | 312 | 205.3 | 1.52 | 29.3 |
| 5 | 12 | 296 | 188.5 | 1.57 | 34.8 |
| 6 | 12 | 293 | 185.4 | 1.58 | 33.7 |
| 7 | 12 | 313 | 203.2 | 1.54 | 25.2 |
| 8 | 12 | 273 | 165.4 | 1.65 | 45.5 |
| 9 | 12 | 253 | 148 | 1.71 | 27.5 |
Claims (5)
1.2-hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute.
2. application according to claim 1, is characterized in that, described 2 hydroxybenzoic acid zinc is the inner complex salt of 2 hydroxybenzoic acid and zinc mol ratio 1:1.
3. application according to claim 1, is characterized in that, described animal is pig.
4. application according to claim 1, is characterized in that, described 2 hydroxybenzoic acid zinc, and its additive capacity in feed for weaned is 100～3000ppm, substitutes high dose ZnO.
5. application according to claim 4, is characterized in that, described 2 hydroxybenzoic acid zinc, and its additive capacity in animal feed is 200～1000ppm.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310738000.7A CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
| PCT/CN2014/070584 WO2015096229A1 (en) | 2013-12-26 | 2014-01-14 | Application of zinc 2-hydroxybenzoate as substitute high-dose zinc oxide for use in feed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310738000.7A CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103749975A true CN103749975A (en) | 2014-04-30 |
| CN103749975B CN103749975B (en) | 2015-08-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310738000.7A Active CN103749975B (en) | 2013-12-26 | 2013-12-26 | 2 hydroxybenzoic acid zinc is as the application of feeding high dose zinc oxide substitute |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103749975B (en) |
| WO (1) | WO2015096229A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041669A (en) * | 2014-05-23 | 2014-09-17 | 广州英赛特生物技术有限公司 | Application of zinc decanoic acid as animal feed additive |
| CN108617856A (en) * | 2018-03-14 | 2018-10-09 | 广州英赛特生物技术有限公司 | Application of the zinc benzoate in preparing animal feed additive |
| WO2020243975A1 (en) * | 2019-06-07 | 2020-12-10 | Dsm Ip Assets B.V. | Use of nutraceutical composition in animal feed |
| CN113950249A (en) * | 2019-06-07 | 2022-01-18 | 帝斯曼知识产权资产管理有限公司 | Use of benzoic acid and essential oil compounds for improving growth performance |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1658768A (en) * | 2002-05-14 | 2005-08-24 | 阿克佐诺贝尔公司 | Method for reducing methane production emanating from the digestive activities of an animal |
| CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
| CN101720856A (en) * | 2008-10-21 | 2010-06-09 | 刘方圆 | Additive of piglet disease-resistant concentrated feed |
| CN101946897A (en) * | 2010-08-11 | 2011-01-19 | 绵阳崴尼达化工有限公司 | Method for producing water-soluble chromium picolinate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102265987B (en) * | 2011-08-25 | 2013-06-26 | 山东新希望六和集团有限公司 | Mixed feed for weaned pigling and preparation method thereof |
| CN102640879B (en) * | 2012-05-24 | 2013-06-26 | 山东新希望六和集团有限公司 | Completely cured suckling pig compound feed and preparation method thereof |
-
2013
- 2013-12-26 CN CN201310738000.7A patent/CN103749975B/en active Active
-
2014
- 2014-01-14 WO PCT/CN2014/070584 patent/WO2015096229A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1658768A (en) * | 2002-05-14 | 2005-08-24 | 阿克佐诺贝尔公司 | Method for reducing methane production emanating from the digestive activities of an animal |
| CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
| CN101720856A (en) * | 2008-10-21 | 2010-06-09 | 刘方圆 | Additive of piglet disease-resistant concentrated feed |
| CN101946897A (en) * | 2010-08-11 | 2011-01-19 | 绵阳崴尼达化工有限公司 | Method for producing water-soluble chromium picolinate |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041669A (en) * | 2014-05-23 | 2014-09-17 | 广州英赛特生物技术有限公司 | Application of zinc decanoic acid as animal feed additive |
| CN104041669B (en) * | 2014-05-23 | 2017-06-23 | 广州英赛特生物技术有限公司 | Capric acid zinc as animal feed additive application |
| CN108617856A (en) * | 2018-03-14 | 2018-10-09 | 广州英赛特生物技术有限公司 | Application of the zinc benzoate in preparing animal feed additive |
| WO2020243975A1 (en) * | 2019-06-07 | 2020-12-10 | Dsm Ip Assets B.V. | Use of nutraceutical composition in animal feed |
| CN113950249A (en) * | 2019-06-07 | 2022-01-18 | 帝斯曼知识产权资产管理有限公司 | Use of benzoic acid and essential oil compounds for improving growth performance |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015096229A1 (en) | 2015-07-02 |
| CN103749975B (en) | 2015-08-19 |
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Effective date of registration: 20161228 Address after: 512400 Guangdong city of Shaoguan province Nanxiong City Abas Industrial Park West No. 8 building three peace Patentee after: Nanxiong yingsaite Fine Chemical Technology Co Ltd Address before: High tech Industrial Development Zone, Guangzhou City, Guangdong province 510530 Science City skim Springs Road No. 3, Guangzhou international business incubator D District No. 415 Patentee before: Guangzhou Insighter Biotechnology Co., Ltd. |