CN108771019B - Feed additive for piglet food calling and intestinal tract and bone development promotion - Google Patents
Feed additive for piglet food calling and intestinal tract and bone development promotion Download PDFInfo
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- CN108771019B CN108771019B CN201810603369.XA CN201810603369A CN108771019B CN 108771019 B CN108771019 B CN 108771019B CN 201810603369 A CN201810603369 A CN 201810603369A CN 108771019 B CN108771019 B CN 108771019B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
Abstract
The invention provides a feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion, which is characterized in that the preparation raw materials at least comprise 2-15 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N-carbamyl glutamic acid chelated copper, 1-5 parts of N-carbamyl glutamic acid chelated zinc, 1-5 parts of manganese methionine, 2-15 parts of glucose, 6-20 parts of sodium butyrate and 1-5 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared by grafting chitosan with naringin dihydrochalcone and 2- (2, 4-difluorophenyl) -1, 3-bi (1H-1,2, 4-triazole-1-yl) -2-propanol.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion.
Background
With the development of the pig raising industry, the operation of pig farms tends to become specialized more and more. The separation of sow farms and nursery-finishing farms makes the trading of piglets more and more frequent. However, because the development of the digestive system and the immune system of the piglets is incomplete, the stress reaction of the piglets is often caused by the change of the nutrition supply and the environment, the feed intake, the growth performance, the intestinal health and the like are reduced, and the phenomena of low daily gain, diarrhea, serious patients and even death occur. The existing means for relieving the stress of the piglets mainly reduces the possibility of infection diseases of the piglets by adding antibiotics in large dose into feed or drinking water, but cannot fundamentally solve the problems of intestinal tract injury, immunosuppression and growth reduction of the piglets, and pathogenic bacteria can generate drug resistance by using a large amount of antibiotics, thereby further threatening the health of animals and human beings.
In addition, the piglet is anemia, the digestion and absorption rate of organisms to nutrient substances is reduced, the nutrition of the piglet is reduced, and further the piglet is light in weight and low in survival rate.
Therefore, aiming at the situation, the invention provides the feed additive for piglet appetizing and promoting the development of the intestinal tract and the skeleton, which promotes the improvement of the development of the digestive system and the immune system of the piglet, increases the feed intake, the growth performance, the intestinal health and the like, and fundamentally solves the problems of piglet intestinal injury, immunosuppression and growth retardation; in addition, the feed additive for piglet food calling and intestinal tract and bone development promotion also has excellent stability.
Disclosure of Invention
In order to solve the problems, the invention provides a feed additive for piglet opening food calling and intestinal tract and skeleton development promotion, which is prepared from the following raw materials, by weight, 2-15 parts of modified oligochitosan, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N-carbamyl glutamic acid chelated copper, 1-5 parts of N-carbamyl glutamic acid chelated zinc, 1-5 parts of methionine manganese, 2-15 parts of glucose, 6-20 parts of sodium butyrate and 1-5 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared from chitosan grafted naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4).
In one embodiment, the raw materials for preparing the chitosan oligosaccharide comprise, by weight, 5-10 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N-carbamylglutamic acid chelated copper, 1-3 parts of N-carbamylglutamic acid chelated zinc, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate and 2-3 parts of yeast selenium.
In one embodiment, the raw materials for preparing the chitosan oligosaccharide comprise, by weight, at least 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamyl glutamic acid chelated copper, 3 parts of N-carbamyl glutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium.
In one embodiment, the molar ratio of the chitosan to the naringin dihydrochalcone, the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: (0.01-0.2): (0.01-0.1).
In one embodiment, the modified oligochitosan has a molecular weight of 3000-50000.
In one embodiment, the amino acids include one or more of lysine, cysteine, glutamic acid.
In one embodiment, the weight ratio of said lysine to said cysteine to said glutamic acid in said amino acid is 1: (1-2): (0.1-1).
In one embodiment, the vitamins include one or more of vitamin a, vitamin C, vitamin D3, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, and vitamin B12.
In one embodiment, the vitamins are vitamin a, vitamin C, vitamin E, vitamin K, vitamin B12, the weight ratio of vitamin a to vitamin C, vitamin E, vitamin K, vitamin B12 is 1: (1-2): (1-2): (0.1-0.2): (0.1-0.5).
The invention also provides a preparation method of the feed additive for piglet food calling and intestinal tract and skeleton development promotion, which at least comprises the following steps:
(1) uniformly mixing the modified chitosan oligomer, the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc and the manganese methionine according to the parts by weight to obtain a premix;
(2) adding vitamins in the step (1) according to the weight parts, uniformly mixing, adding iron porphyrin, cheese, amino acid, glucose, sodium butyrate and selenium yeast, and uniformly mixing to obtain the feed additive for piglet opening food calling and intestinal tract and bone development promotion.
The above-described and other features, aspects, and advantages of the present application will become more apparent with reference to the following detailed description.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
The invention provides a feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion, which comprises the following raw materials, by weight, 2-15 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N-carbamyl glutamic acid chelated copper, 1-5 parts of N-carbamyl glutamic acid chelated zinc, 1-5 parts of manganese methionine, 2-15 parts of glucose, 6-20 parts of sodium butyrate and 1-5 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared from chitosan grafted naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4).
The chitosan is a product of chitosan deacetylation, is basic polysaccharide, is one of a few natural products with charges, has the effects of broad-spectrum bacteriostasis, organism immunity enhancement, animal production performance improvement, animal meat quality improvement and water quality purification, has wide sources, is nontoxic, harmless, residue-free, drug-resistant, safe and efficient, and is a feed additive with high development value.
The chitosan has obvious inhibition and killing effects on various bacteria such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like, and shows stronger antibacterial activity. However, compared with the existing chemical synthetic antibacterial agent, the antibacterial activity is still low, the antibacterial activity on fungi is basically not inhibited, and the inhibition effect of chitosan is weakened due to the increase of molecular weight, which is related to that the larger the molecular weight of chitosan is, the poorer the water solubility is, thereby the antibacterial activity is weakened.
Naringin dihydrochalcone can damage the plasma membrane of bacterial cell, inhibit the synthesis of bacterial nucleic acid, inhibit the energy metabolism of bacteria, inhibit the synthesis of bacterial cell wall, and inhibit the synthesis of bacterial cell membrane.
2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol with Cu2+The activity of the ion-formed complex supermolecule against candida albicans is far better than that of 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, and the complex supermolecule has the inhibiting capability on candida albicans.
The preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of a reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding naringin dihydrochalcone, reacting for 2 hours under heat preservation, then adding 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, reacting for 1.5 hours under heat preservation, filtering, washing for 3 times by using purified water, and drying for 24 hours under reduced pressure at 60 ℃ to obtain the modified oligomeric chitosan.
In one embodiment, the raw materials for preparing the chitosan oligosaccharide comprise, by weight, 5-10 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N-carbamylglutamic acid chelated copper, 1-3 parts of N-carbamylglutamic acid chelated zinc, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate and 2-3 parts of yeast selenium.
In one embodiment, the raw materials for preparing the chitosan oligosaccharide comprise, by weight, at least 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamyl glutamic acid chelated copper, 3 parts of N-carbamyl glutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium.
In one embodiment, the molar ratio of the chitosan to the naringin dihydrochalcone, the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: (0.01-0.2): (0.01-0.1); preferably, the molar ratio of the chitosan to the naringin dihydrochalcone, the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.12: 0.05.
in one embodiment, the modified oligochitosan has a molecular weight of 3000-50000; preferably, the molecular weight of the modified oligochitosan is 8000-10000.
In one embodiment, the amino acids include one or more of lysine, cysteine, glutamic acid.
In one embodiment, the weight ratio of said lysine to said cysteine to said glutamic acid in said amino acid is 1: (1-2): (0.1-1); preferably, the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6.
in one embodiment, the vitamins include one or more of vitamin a, vitamin C, vitamin D3, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, and vitamin B12.
In one embodiment, the vitamins are vitamin a, vitamin C, vitamin E, vitamin K, vitamin B12, the weight ratio of vitamin a to vitamin C, vitamin E, vitamin K, vitamin B12 is 1: (1-2): (1-2): (0.1-0.2): (0.1-0.5); preferably, the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3.
the invention also provides a preparation method of the feed additive for piglet food calling and intestinal tract and skeleton development promotion, which at least comprises the following steps:
(1) uniformly mixing the modified chitosan oligomer, the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc and the manganese methionine according to the parts by weight to obtain a premix;
(2) adding vitamins in the step (1) according to the weight parts, uniformly mixing, adding iron porphyrin, cheese, amino acid, glucose, sodium butyrate and selenium yeast, and uniformly mixing to obtain the feed additive for piglet opening food calling and intestinal tract and bone development promotion.
According to the invention, the feed intake and daily gain of piglets can be greatly improved and the growth performance of the piglets can be improved by using the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc, the manganese methionine, the vitamins, the iron porphyrin, the cheese, the amino acid, the glucose, the sodium butyrate and the selenium yeast; the N-carbamylglutamic acid chelated copper and the N-carbamylglutamic acid chelated zinc can not only provide organic trace elements, but also improve the intestinal health and the anti-stress capability of piglets. The glucose and the sodium butyrate can rapidly provide energy for intestinal tracts of piglets, effectively improve the gastrointestinal tract function of the piglets, improve the digestion capacity and the feed intake of the piglets and reduce the occurrence of gastrointestinal tract diseases.
The modified chitosan oligosaccharide has obvious inhibiting and killing effects on various bacteria such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans and the like, shows stronger antibacterial activity and promotes the storage stability of the feed additive; but also can well solve the defects of unstable glutamine and easy degradation.
In addition, naringin dihydrochalcone also has excellent antioxidant function and can inhibit nitration reaction of protein caused by peroxynitroso ONOO-; it can be complexed with transition metal ions to promote the efficient absorption and utilization of the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc and the methionine manganese in the bodies of the piglets.
The feed additive has reasonable formula design, provides complete and balanced nutrition for piglets, provides original hematopoietic and qi-tonifying nutrition, solves the problem that the fed piglets often suffer from anemia in the growth period, provides sufficient nutrition for the rapid growth and development of the piglets, and has high survival rate; on the other hand, the piglet feed intake is increased, the intestinal tract is healthy, and the autoimmunity is enhanced.
The feed additive for piglet appetitive feeding and intestinal tract and bone development promotion is added into piglet ration to prepare piglet feeding feed, and the dosage of the feed additive for piglet appetitive feeding and intestinal tract and bone development promotion is 0.1-0.5% of the mass of the piglet feeding feed.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Example 1
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.12: 0.05; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet food calling and intestinal tract and skeleton development promotion comprises the following steps:
(1) uniformly mixing the modified chitosan oligomer, the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc and the manganese methionine according to the parts by weight to obtain a premix;
(2) adding vitamins in the step (1) according to the weight parts, uniformly mixing, adding iron porphyrin, cheese, amino acid, glucose, sodium butyrate and selenium yeast, and uniformly mixing to obtain the feed additive for piglet opening food calling and intestinal tract and bone development promotion.
The preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of a reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding naringin dihydrochalcone, reacting for 2 hours under heat preservation, then adding 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, reacting for 1.5 hours under heat preservation, filtering, washing for 3 times by using purified water, and drying for 24 hours under reduced pressure at 60 ℃ to obtain the modified oligomeric chitosan.
Example 2
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises, by weight, 5 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.12: 0.05; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet feeding attraction and intestinal tract and skeleton development promotion and the preparation method of the modified chitosan oligosaccharide are the same as those in example 1.
Example 3
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises, by weight, 10 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.12: 0.05; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet feeding attraction and intestinal tract and skeleton development promotion and the preparation method of the modified chitosan oligosaccharide are the same as those in example 1.
Example 4
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.01: 0.1; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet feeding attraction and intestinal tract and skeleton development promotion and the preparation method of the modified chitosan oligosaccharide are the same as those in example 1.
Example 5
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.2: 0.01; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet feeding attraction and intestinal tract and skeleton development promotion and the preparation method of the modified chitosan oligosaccharide are the same as those in example 1.
Comparative example 1
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; the modified chitosan oligosaccharide is prepared by grafting naringin dihydrochalcone (18916-17-1) with chitosan, and the molar ratio of the chitosan to the naringin dihydrochalcone is 1: 0.12; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is the same as that in example 1.
The preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of a reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding naringin dihydrochalcone, reacting for 2 hours under the condition of heat preservation, filtering, washing for 3 times by using purified water, and drying for 24 hours under reduced pressure at 60 ℃ to obtain the modified oligochitosan.
Comparative example 2
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of modified chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the modified chitosan oligosaccharide is prepared by grafting 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4) with chitosan, and the molar ratio of the chitosan to the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.05; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is the same as that in example 1.
The preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of the reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, reacting for 1.5H under the condition of heat preservation, filtering, washing for 3 times by using purified water, and drying for 24H under reduced pressure at 60 ℃ to obtain the modified oligochitosan.
Comparative example 3
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the molecular weight of the chitosan is 8000; the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is the same as that in example 1.
Comparative example 4
The feed additive for piglet feeding and intestinal tract and skeleton development promotion comprises 8 parts of chitosan oligosaccharide, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium by weight; wherein the modified chitosan oligosaccharide is prepared from chitosan grafted naringin dihydrochalcone (18916-17-1) and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol (86386-73-4), and the molecular weight of the chitosan oligosaccharide is 20000; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is the same as that in example 1.
Comparative example 5
The feed additive for piglet feeding promotion and intestinal tract and skeleton development promotion comprises, by weight, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of methionine manganese, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium; wherein the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6; the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12, and the weight ratio of the vitamin A to the vitamin C, the vitamin E, the vitamin K and the vitamin B12 is 1: 1.5: 1.2: 0.12: 0.3;
the preparation method of the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is the same as that in example 1.
Performance testing
1. Selecting 550 piglets after 28-day-old transportation, randomly dividing into 10 treatment groups according to weight and sex by adopting single-factor test design, adding no additive of the invention into a control group, adding 0.1 wt% of feed additive into the treatment group, and carrying out a test period of 21 days. The influence of the piglet production performance and diarrhea rate of the feed additive
2. The feed additive for piglet food calling and intestinal tract and skeleton development promotion has stability
Placing the feed additive for piglet hatch food calling and intestinal tract and bone development promotion at the temperature of 45 ℃ and the air humidity of 90% for 40 days, and observing the color and smell of the feed additive for piglet hatch food calling and intestinal tract and bone development promotion;
all characteristics of the 5 point product are completely consistent with the standard sample;
a 4 point product was acceptable, but slightly different compared to the standard sample;
the 3 points of the product are acceptable, but have obvious difference compared with the standard sample;
2 points of the product are somewhat unacceptable;
the 1 minute product was completely unacceptable.
Table 1 results of performance testing
The data show that the feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion provided by the invention can promote the complete development of the digestive system and immune system of piglets and increase the feed intake, growth performance, intestinal tract health and the like, so that the problems of piglet intestinal tract injury, immunosuppression and growth retardation are fundamentally solved; in addition, the feed additive for piglet food calling and intestinal tract and bone development promotion also has excellent stability.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (8)
1. The feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is characterized in that the preparation raw materials at least comprise 2-15 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N-carbamyl glutamic acid chelated copper, 1-5 parts of N-carbamyl glutamic acid chelated zinc, 1-5 parts of manganese methionine, 2-15 parts of glucose, 6-20 parts of sodium butyrate and 1-5 parts of yeast selenium; wherein the modified chitosan oligosaccharide is prepared by grafting chitosan with naringin dihydrochalcone and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol;
the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: (0.01-0.2): (0.01-0.1);
the molecular weight of the modified oligochitosan is 3000-50000;
the preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of a reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding naringin dihydrochalcone, reacting for 2 hours under heat preservation, then adding 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, reacting for 1.5 hours under heat preservation, filtering, washing for 3 times by using purified water, and drying for 24 hours under reduced pressure at 60 ℃ to obtain the modified oligomeric chitosan.
2. The feed additive for piglet feeding attraction and intestinal tract and skeleton development promotion according to claim 1 is characterized in that the raw materials for preparation at least comprise 5-10 parts of modified chitosan oligosaccharide, 0.1-5 parts of porphyrin iron, 5-10 parts of cheese, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N-carbamylglutamic acid chelated copper, 1-3 parts of N-carbamylglutamic acid chelated zinc, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate and 2-3 parts of yeast selenium.
3. The feed additive for piglet feeding attraction and intestinal tract and bone development promotion according to claim 1, wherein the amino acid comprises one or more of lysine, cysteine and glutamic acid.
4. The feed additive for piglet appetite promotion and intestinal tract and bone development according to claim 3, wherein the weight ratio of the lysine to the cysteine to the glutamic acid in the amino acid is 1: (1-2): (0.1-1).
5. The feed additive for piglet appetite stimulation and intestinal and skeletal development according to claim 1, wherein the vitamins comprise vitamin A, vitamin C, vitamin D3Vitamin E, vitamin K and vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of them.
6. The feed additive according to claim 1 for piglet appetite promotion and intestinal and skeletal development promotionThe agent is characterized in that the vitamins are vitamin A, vitamin C, vitamin E, vitamin K and vitamin B12Said vitamin A is in contact with said vitamin C, said vitamin E, said vitamin K, said vitamin B12The weight ratio of (1): (1-2): (1-2): (0.1-0.2): (0.1-0.5).
7. The feed additive for piglet appetitive feeding and intestinal tract and skeleton development promotion is characterized in that the preparation raw materials at least comprise 8 parts of modified oligochitosan, 2 parts of porphyrin iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N-carbamylglutamic acid chelated copper, 3 parts of N-carbamylglutamic acid chelated zinc, 1 part of methionine manganese, 8 parts of glucose, 10 parts of sodium butyrate and 2 parts of yeast selenium in parts by weight;
the modified chitosan oligomer is prepared by grafting chitosan with naringin dihydrochalcone and 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazole-1-yl) -2-propanol; the molar ratio of the chitosan to the naringin dihydrochalcone and the 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol is 1: 0.12: 0.05;
the amino acid is lysine, cysteine and glutamic acid, and the weight ratio of the lysine to the cysteine to the glutamic acid is 1: 1.2: 0.6;
the vitamins include vitamin A, vitamin C, vitamin E, vitamin K, and vitamin B12Said vitamin A is in contact with said vitamin C, said vitamin E, said vitamin K, said vitamin B12The weight ratio of (1): 1.5: 1.2: 0.12: 0.3;
the preparation method of the modified chitosan oligosaccharide comprises the following steps:
(1) adding chitosan and 2mol/L hydrochloric acid solution into a reactor, stirring until the chitosan is dissolved, placing a reaction system in an ice bath, adding sodium nitrite when the temperature is between-5 and 0 ℃, keeping the temperature for reaction, stopping the reaction until the reaction solution is detected to enable the potassium iodide starch test paper to be bluish purple, and neutralizing the redundant sodium nitrite by using urea; the weight ratio of the chitosan to the hydrochloric acid solution to the sodium nitrite is 1: 20: 1.1; the molecular weight of the chitosan is 8000;
(2) and (2) introducing nitrogen into the step (1), heating to 20 ℃, adjusting the pH value of a reaction system to 7.5 by using 1mol/L sodium hydroxide solution, slowly adding naringin dihydrochalcone, reacting for 2 hours under heat preservation, then adding 2- (2, 4-difluorophenyl) -1, 3-bis (1H-1,2, 4-triazol-1-yl) -2-propanol, reacting for 1.5 hours under heat preservation, filtering, washing for 3 times by using purified water, and drying for 24 hours under reduced pressure at 60 ℃ to obtain the modified oligomeric chitosan.
8. The preparation method of the feed additive for piglet food calling and intestinal tract and bone development promotion according to any one of claims 1-7, is characterized by at least comprising the following steps:
(1) uniformly mixing the modified chitosan oligomer, the N-carbamylglutamic acid chelated copper, the N-carbamylglutamic acid chelated zinc and the manganese methionine according to the parts by weight to obtain a premix;
(2) adding vitamins in the step (1) according to the weight parts, uniformly mixing, adding iron porphyrin, cheese, amino acid, glucose, sodium butyrate and selenium yeast, and uniformly mixing to obtain the feed additive for piglet opening food calling and intestinal tract and bone development promotion.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105669878A (en) * | 2016-03-28 | 2016-06-15 | 宁波科瑞特动物药业有限公司 | Modified oligochitosan for aquaculture and preparation method thereof |
| CN105777381A (en) * | 2016-04-12 | 2016-07-20 | 河南捷农生化有限公司 | Medium trace element compound fertilizer containing vitamin B and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105669878A (en) * | 2016-03-28 | 2016-06-15 | 宁波科瑞特动物药业有限公司 | Modified oligochitosan for aquaculture and preparation method thereof |
| CN105777381A (en) * | 2016-04-12 | 2016-07-20 | 河南捷农生化有限公司 | Medium trace element compound fertilizer containing vitamin B and preparation method thereof |
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