Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of gout; Chinese medicine preparation of the present invention has the effect of the silt of invigorating blood circulation, reducing swelling and alleviating pain, dredging collateral eliminating impediment, can effectively reduce blood uric acid, for symptoms such as pain wind-induced joint severe pain, swelling, erythema, stiff, heatings, there is remarkable therapeutical effect, alleviate patient's misery, and preparation technology is simple, instant effect, without any side effects, treating both the principal and secondary aspects of a disease, clinic wide popularization and application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for gout, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of gout, comprise following processing step:
(1) Herba Menthae, Flos jasmini, fevervine, Rhizoma Paridis, Semen Plantaginis, the Radix Astragali, Herba Aconiti Ochranthi, Rhizoma Ligustici, Radix Paeoniae Alba and Herba Scutellariae Barbatae are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, standby;
(2) river cypress, Radix Saposhnikoviae and fructus amomi are put into pot and mixed thoroughly with yellow wine sprinkle, then with slow fire, fry, after fried dry, take out, grind into powder, cross 200 order fine powders, standby;
(3) Herba Oenanthes Javanicae is cleaned, put shady and cool place and dry, chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(4) after Rhizoma Corydalis Decumbentis and Radix Puerariae are dried, put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, standby;
(5) above-mentioned steps (1)~(4) prepared filtrate, juice and fine powder are mixed, make tablet, obtain the Chinese medicine preparation for the treatment of gout of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Menthae: acrid in the mouth, cool in nature; Enter lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Cure mainly affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.< < medicineization justice > > carries: " get that its gas is fragrant and sharp key is apt to away flesh table, with the edema that disappears, loose flesh heat, except backache, draws medicine administered to bring out the cold and join the army to defend to dredge and tie stagnant gas." modern medicine study confirms, the skin that Herba Menthae can be nursed one's health is unclean, block, the sensation that it is refrigerant, can shrink blood capillary, releive itch, inflammation and burning, also can soft skin, for removing blackhead and oiliness skin quality, also have effect.
Flos jasmini: mildly bitter flavor, property is flat; Return Liver Channel.Soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.The side of body rib gastral cavity abdomen curing mainly due to stagnation of QI due to depression of the liver is had a pain, dysentery stomachache.The conventional Chinese herbal medicine handbook > > of the < < of Guangzhou army carries: " treating the liver is scorching, the hepatic region of liver cirrhosis is sick, and costa sternales does not relax, heart peratodynia, dysentery stomachache.”
River cypress: bitter in the mouth, cold in nature; Enter kidney, urinary bladder channel.Heat clearing and damp drying, eliminating fire and detoxication.Cure mainly hematodiarrhoea, have loose bowels, quench one's thirst, jaundice , flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.According to < < Japan hanako materia medica > >, carry: " feel at ease, except labor, to control hectic fever due to YIN-deficiency, wash liver, improving eyesight, many tear; xerostomia, heat in the heart, kills infantile malnutrition worm, controls ascarid pained, scabies; processed with honey is controlled serious epistaxis, and hemorrhoidal hamorrhage, rushes down blood, divides afterwards anxious heat to swell and ache.”
Fevervine: sweet in the mouth, micro-hardship, property is flat.Expelling wind and removing dampness, promoting digestion and removing stagnation, cough-relieving pain relieving.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall, gastrointestinal angor, icterohepatitis, enteritis, dysentery, dyspepsia, infantile malnutrition, hemoptysis of pulmonary tuberculosis, bronchitis, the leukopenia that radiation reaction causes, pesticide intoxication; Dermatitis is controlled in external, eczema, sore swollen toxin.
Rhizoma Paridis: bitter in the mouth, cool in nature, mild toxicity; GUIXIN, liver, lung, stomach, large intestine channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Cure mainly carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat is twitched.Modern medicine study confirmation, Rhizoma Paridis has good result to the woman's galactostasis of managing property.
Herba Oenanthes Javanicae: sweet in the mouth, property is flat.Clearing away heat-damp and promoting diuresis, hemostasis, blood pressure lowering.For cold, fever, vomiting and diarrhoea, urinary tract infection, metrorrhagia, leucorrhea, hypertension.In < <, traditional Chinese medicines are planted will > > and are carried: " tender stem is smash juice clothes, can control vascular hypertension.”
Semen Plantaginis: sweet in the mouth, light, cold nature; Return lung, liver, kidney, urinary bladder channel; The < < property of medicine > > that falls carries: " can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." modern medicine study confirmation, Herba Plantaginis clearing away heat and promoting diuresis, removing heat from blood, the effect of removing toxic substances.
The Radix Astragali: sweet in the mouth, slightly warm in nature; Return lung, spleen, liver, kidney channel.Benefiting QI for strengthening the superficies, arresting sweating is admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
Rhizoma Corydalis Decumbentis: bitter in the mouth, pungent, cool in nature; Return liver, kidney channel.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain, blood pressure lowering.Cure mainly rheumatic arthritis, apoplectic hemiplegia, sciatica, poliomyelitis sequela, lumbar muscle strain, injury from falling down, hypertension.Jiangxi < < Chinese herbology > > carries: " blood pressure lowering pain relieving, promoting flow of QI and blood.Control various hypertension, hemiplegia disease, rheumatic arthritis, lumbar muscle strain.”
Herba Aconiti Ochranthi: bitter in the mouth, warm in nature, poisonous.Wind-expelling pain-stopping, relieving cough and asthma, reduces phlegm.For chronic bronchitis, lumbago and skelalgia, arthralgia; Scabies is controlled in external, tuberculous lymphadenitis.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Return bladder, lung, spleen, Liver Channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.< < Changsha medicine solution > > carries: " network of passing through, by wet excessive, gets round by bribery, and pain relieves the pain; relaxing muscles and tendons arteries and veins, stretches anxious twinly, and the podomere of living; play paralysis, hold back spontaneous perspiration, night sweat, breaks, metrorrhagia.”
Fructus amomi; Acrid in the mouth, warm in nature; Return spleen, stomach, kidney three warps.Circulation of qi promoting and in, stomach function regulating is amusing, astringing to arrest diarrhea is regulated the flow of vital energy antiabortive, fragrant dampness, the chest stuffiness relieving stomach invigorating.Be mainly used to the multiple digestive tract disease due to stagnation of QI in spleen and stomach or deficiency of QI in middle-JIAO, as chest and diaphragm distension, stagnation of QI food stagnation, vomiting is had loose bowels, and diet enters less; Or weakness of the spleen and stomach, the cold dysentery that slides be can't help; Or vomiting during pregnancy, frequent fetal movement, threatened abortion.
Rhizoma Ligustici: acrid in the mouth, warm in nature; Return urinary bladder channel.Expelling wind and cold, removing damp and stopping pain.For anemofrigid cold, top, mountain peak pain, rheumatic arthralgia.< < pearl sac > > carries: " control TAI YANG headache, parietal headache, violates brain Great Cold, and pain connects tooth cheek." modern medicine study confirmation, Rhizoma Ligustici neutral oil has calmness, analgesia, antipyretic and antiinflammatory action, and can suppress intestinal and uterine smooth muscle, and keto consumpting speed can also obviously slow down.
Radix Paeoniae Alba: sour in the mouth, be slightly cold, slightly poisonous.Clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood, gas anhydrates.Row cold and heat while curing mainly, attacked by pestiferous factors, stomachache, lumbago.< < property of medicine opinion > > carries: " minister can be controlled pathogen of the lung gas; convulsive abdominal pain, and vim and vigour are gathered, and logical a surname's internal organs are gathered around gas; control evil pain deteriorated blood; disease bone heat when main, strong the five internal organs, and the kidney invigorating gas; control trusted subordinate's heavily fortified point swollen; married woman's blood closes obstructed, repercussive blood, can lose pus." modern medicine study proves, Radix Paeoniae Alba has the effect of protecting well and taking good care of to human body cardiovascular and cerebrovascular vessel, human central nervous slight illness is had to treatment and inhibitory action well.
Radix Puerariae: sweet in the mouth, pungent, property is flat; Enter spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.< < does not record > > and carries: " the excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles, delivers, perspires, loosing the interspaces of skin and muscles.Treat incised wound, pain relieving, side of body wind pain.The juice of taking root, treatment is quenched one's thirst, typhoid fever high fever." modern medicine study, Radix Puerariae flavone has cancer-resisting and estrogen-like effects, can promote women's breast enlargement, skin care, especially obvious to middle-aged women and the effect of menopausal women face-nourishing health-care.
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature; Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.Modern medicine study confirmation, Herba Scutellariae Barbatae 50% decoct has inhibitory action to staphylococcus aureus, shigella flexneri, Bacillus typhi, bacillus pyocyaneus, escherichia coli.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention has the effect of the silt of invigorating blood circulation, reducing swelling and alleviating pain, dredging collateral eliminating impediment, can effectively reduce blood uric acid, for symptoms such as pain wind-induced joint severe pain, swelling, erythema, stiff, heatings, there is remarkable therapeutical effect, alleviate patient's misery, and preparation technology is simple, instant effect, without any side effects, treating both the principal and secondary aspects of a disease, clinic wide popularization and application.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Treat a preparation method for the Chinese medicine preparation of gout, comprise following processing step:
(1) Herba Menthae, Flos jasmini, fevervine, Rhizoma Paridis, Semen Plantaginis, the Radix Astragali, Herba Aconiti Ochranthi, Rhizoma Ligustici, Radix Paeoniae Alba and Herba Scutellariae Barbatae are cleaned, put into container, add the distilled water of 8~10 times of amounts, soak after 5~6 hours, boil 3~4 hours, extract; Again add 6~8 times of amount distilled water, boil 2~3 hours, extract; Finally, add 4~6 times of amount distilled water, heated and boiled 1~2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, standby;
(2) river cypress, Radix Saposhnikoviae and fructus amomi are put into pot and mixed thoroughly with yellow wine sprinkle, then with slow fire, fry, after fried dry, take out, grind into powder, cross 200 order fine powders, standby;
(3) Herba Oenanthes Javanicae is cleaned, put shady and cool place and dry, chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(4) after Rhizoma Corydalis Decumbentis and Radix Puerariae are dried, put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, standby;
(5) above-mentioned steps (1)~(4) prepared filtrate, juice and fine powder are mixed, make tablet, obtain the Chinese medicine preparation for the treatment of gout of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, can fully recover 2~3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
Chinese medicine preparation as treatment gout, the routine clinical observation of patient with gout 200 that selection is made a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups, treatment group 100 examples, wherein male's 49 examples at random, women's 51 examples, 35~60 years old age, 53.5 years old mean age, the shortest person of the course of disease 3 months, elder 6 years, average 3.1 years.Matched group 100 examples, male's 50 examples wherein, women's 50 examples, 33~61 years old age, 51.3 years old mean age, the shortest person of the course of disease 4 months, elder 7 years, average 3.5 years.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, take continuously 2~3 courses for the treatment of and can fully recover, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken diclofenac sodium enteric-coated tablets, and each 75~150mg 1 time weekly, is used in conjunction 2 times; Within 20 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, 2~3 courses for the treatment of of severe one, the person of being in a bad way is conventionally invalid.
3, efficacy determination:
(1) cure: the transference cure such as red, swollen, hot, to have an intense pain, local inflammation elimination, joint motion is freely.
(2) effective: above-mentioned symptom obviously alleviates, joint motion is clearly better.
(3) effective: above-mentioned symptom is alleviated to some extent, and joint motion makes moderate progress.
(4) invalid: clinical symptoms is not improved.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 60 examples, effective 20 examples, effective 16 examples, invalid 4 examples, cure rate 60%, total effective rate 96%.
In matched group, cure 11 examples, effective 20 examples, effective 21 examples, invalid 48 examples, cure rate 11%, total effective rate 52%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Cai, man, 38 years old, people from Huaian, Jiangsu.Patient has clear and definite gout medical history, left knee joint skin temperature significantly raises, whole arthroncus, press synovial bursae and have fluctuation, cold weather just occurs that left knee joint has an intense pain, enlargement, can not bend and stretch, the uric acid 620umol/l that has a blood test is admitted to hospital, erythrocyte sedimentation rate 53mm/h, for the state of an illness, take Chinese medicine preparation of the present invention after 1 course for the treatment of, arthralgia significantly takes a turn for the better, and does not look into and sees arthroedema, bend and stretch function substantially not limited, take continuously Chinese medicine preparation of the present invention after 2 courses for the treatment of, symptom disappears completely, and it is normal that indices has recovered.
2, Jiang, man, 45 years old, people from Shenyang, Liaoning.The right ankle joint of patient swells and ache, and removes hospital admission, finds micro-swollen, the pain of right ankle joint, and it is inconvenient that activity is slightly felt, when right foot is stepped on hard thing, the pain increased, local slight fever, and local skin is dark red, the pain of pressure, the strong side of Pi Wen is slightly high, is diagnosed as gout.Take Chinese medicine preparation of the present invention after 1 course for the treatment of, right ankle joint swells and ache and obviously disappears, and takes Chinese medicine preparation of the present invention after 2 courses for the treatment of, and right ankle joint swells and ache and disappears completely, follows up a case by regular visits to not recurrence after 1 year.
3, go into business certain, female, 60 years old, Taizhou of Zhejiang people.The left ankle joint of patient is congestion and swelling pain repeatedly, and removing hospital diagnosis is gout, takes after western medicine tablet treatment, and pain is alleviated to some extent, posterior joint pain Chang Fanfu outbreak.To our hospital, take Chinese medicine preparation of the present invention, to take after 1 course for the treatment of, the state of an illness is alleviated to some extent, takes after 2 courses for the treatment of, and the state of an illness is progressively alleviated, is improved, and follows up a case by regular visits to so far not recurrence.