Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of gout; Chinese medicine preparation of the present invention has effect of silt of invigorating blood circulation, reducing swelling and alleviating pain, dredging collateral eliminating impediment, effectively can reduce blood uric acid, for symptoms such as pain wind-induced joint severe pain, swelling, erythema, stiff, heatings, there is remarkable therapeutical effect, alleviate the misery of patient, and preparation technology is simple, instant effect, without any side effects, treating both the principal and secondary aspects of a disease, clinic wide popularization and application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for gout, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of gout, comprise following processing step:
(1) Herba Menthae, Flos jasmini, fevervine, Rhizoma Paridis, Semen Plantaginis, the Radix Astragali, Herba Aconiti Ochranthi, Rhizoma Ligustici, Radix Paeoniae Alba and Herba Scutellariae Barbatae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) river cypress, Radix Saposhnikoviae and fructus amomi are put into pot yellow wine sprinkle to mix thoroughly, then fry with slow fire, take out after fried dry, grind into powder, cross 200 order fine powders, for subsequent use;
(3) cleaned by Herba Oenanthes Javanicae, put shady and cool place and dry, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) after Rhizoma Corydalis Decumbentis and Radix Puerariae being dried, put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), juice and fine powder mixing, make tablet, obtain the Chinese medicine preparation for the treatment of gout of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Menthae: acrid in the mouth, cool in nature; Enter lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Cure mainly affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest." medicineization justice " carries: " get the fragrant and sharp key of its gas, be apt to away flesh table, with disappearing edema, loose flesh heat, except backache, draws medicine administered to bring out the cold and join the army and defend with the stagnant gas of thin knot." modern medicine study confirms, Herba Menthae can nurse one's health skin that is unclean, that block, its refrigerant sensation, can blood capillary be shunk, releive itch, inflammation and burning, also can soft skin, also effect is had for removing blackhead and oiliness skin quality.
Flos jasmini: mildly bitter flavor, property is put down; Return Liver Channel.Soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.The side of body rib gastral cavity abdomen cured mainly caused by stagnation of QI due to depression of the liver is had a pain, and dysentery is suffered from abdominal pain.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " treating the liver hepatic region that is scorching, liver cirrhosis is sick, and costa sternales does not relax, heart peratodynia, and dysentery is suffered from abdominal pain.”
River cypress: bitter in the mouth, cold in nature; Enter kidney, urinary bladder channel.Heat clearing and damp drying, eliminating fire and detoxication.Cure mainly hematodiarrhoea, have loose bowels, quench one's thirst, jaundice , flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, and hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Carry according to " Japan hanako materia medica ": " feel at ease except labor, control hectic fever due to YIN-deficiency, wash liver, improving eyesight, many tear, xerostomia, heat in the heart, kill infantile malnutrition worm, control ascarid pained, scabies, processed with honey controls serious epistaxis, and hemorrhoidal hamorrhage rushes down blood, and rear point anxious heat swells and ache.”
Fevervine: sweet in the mouth, micro-hardship, property is put down.Expelling wind and removing dampness, promoting digestion and removing stagnation, cough-relieving pain relieving.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall, gastrointestinal angor, icterohepatitis, enteritis, dysentery, dyspepsia, infantile malnutrition, hemoptysis of pulmonary tuberculosis, bronchitis, the leukopenia that radiation reaction causes, pesticide intoxication; Dermatitis is controlled in external, eczema, sore swollen toxin.
Rhizoma Paridis: bitter in the mouth, cool in nature, mild toxicity; GUIXIN, liver, lung, stomach, large intestine channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Cure mainly carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat is twitched.Modern medicine study confirms, Rhizoma Paridis has good result to woman's galactostasis of managing property.
Herba Oenanthes Javanicae: sweet in the mouth, property is put down.Clearing away heat-damp and promoting diuresis, hemostasis, blood pressure lowering.For cold, fever, vomiting and diarrhoea, urinary tract infection, metrorrhagia, leucorrhea, hypertension." will planted by middle traditional Chinese medicines " carries: " tender stem smashes juice clothes, can control vascular hypertension.”
Semen Plantaginis: sweet in the mouth, light, cold nature; Return lung, liver, kidney, urinary bladder channel; " property of medicine is fallen " carries: " can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." modern medicine study confirmation, Herba Plantaginis clearing away heat and promoting diuresis, removing heat from blood, the effect of removing toxic substances.
The Radix Astragali: sweet in the mouth, slightly warm in nature; Return lung, spleen, liver, kidney channel.Benefiting QI for strengthening the superficies, arresting sweating takes off admittedly, holder skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
Rhizoma Corydalis Decumbentis: bitter in the mouth, pungent, cool in nature; Return liver, kidney channel.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain, blood pressure lowering.Cure mainly rheumatic arthritis, apoplectic hemiplegia, sciatica, poliomyelitis sequela, lumbar muscle strain, injury from falling down, hypertension.Jiangxi " Chinese herbology " is carried: " blood pressure lowering pain relieving, promoting flow of QI and blood.Control various hypertension, hemiplegia disease, rheumatic arthritis, lumbar muscle strain.”
Herba Aconiti Ochranthi: bitter in the mouth, warm in nature, poisonous.Wind-expelling pain-stopping, relieving cough and asthma, reduces phlegm.For chronic bronchitis, lumbago and skelalgia, arthralgia; Scabies is controlled in external, tuberculous lymphadenitis.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Return bladder, lung, spleen, Liver Channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of." Changsha medicine solution " carries: " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, podomere of living, and plays paralysis, holds back spontaneous perspiration, night sweat, break, metrorrhagia.”
Fructus amomi; Acrid in the mouth, warm in nature; Return spleen, stomach, kidney three warp.Circulation of qi promoting and in, stomach function regulating is amusing, astringing to arrest diarrhea, regulates the flow of vital energy antiabortive, fragrant dampness, the chest stuffiness relieving stomach invigorating.Be mainly used to the multiple digestive tract disease caused by stagnation of QI in spleen and stomach or deficiency of QI in middle-JIAO, as chest and diaphragm distension, stagnation of QI food stagnation, vomiting is had loose bowels, and diet enters less; Or weakness of the spleen and stomach, the cold dysentery that slides be can't help; Or vomiting during pregnancy, frequent fetal movement, threatened abortion.
Rhizoma Ligustici: acrid in the mouth, warm in nature; Return urinary bladder channel.Expelling wind and cold, removing damp and stopping pain.For anemofrigid cold, top, mountain peak pain, rheumatic arthralgia." pearl sac " carries: " control TAI YANG headache, parietal headache, Great Cold violates brain, and pain connects tooth cheek." modern medicine study confirmation, Rhizoma Ligustici neutral oil has calmness, analgesia, antipyretic and antiinflammatory action, and can suppress intestinal and uterine smooth muscle, and can also obviously slow down keto consumpting speed.
Radix Paeoniae Alba: sour in the mouth, is slightly cold, slightly poisonous.Clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas.Row cold and heat when curing mainly, attacked by pestiferous factors, stomachache, lumbago." property of medicine opinion " carries: " minister can control pathogen of the lung gas, convulsive abdominal pain, and vim and vigour are gathered, and logical a surname's internal organs gather around gas, controls evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." modern medicine study proves, Radix Paeoniae Alba has the effect of protecting well and taking good care of to human body cardiovascular and cerebrovascular vessel, have treatment and inhibitory action well to human central nervous slight illness.
Radix Puerariae: sweet in the mouth, pungent, property is put down; Enter spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf." not Lu " carries: " excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles, delivers, and perspires, loosing the interspaces of skin and muscles.Treat incised wound, pain relieving, side of body wind pain.Take root juice, treatment is quenched one's thirst, typhoid fever high fever." modern medicine study, Radix Puerariae flavone has cancer-resisting and estrogen-like effects, can promote women's breast enlargement, skin care, especially to middle-aged women and the effect of menopausal women face-nourishing health-care obvious.
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature; Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.Modern medicine study confirms, Herba Scutellariae Barbatae 50% decoct has inhibitory action to staphylococcus aureus, shigella flexneri, Bacillus typhi, bacillus pyocyaneus, escherichia coli.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention has effect of silt of invigorating blood circulation, reducing swelling and alleviating pain, dredging collateral eliminating impediment, effectively can reduce blood uric acid, for symptoms such as pain wind-induced joint severe pain, swelling, erythema, stiff, heatings, there is remarkable therapeutical effect, alleviate the misery of patient, and preparation technology is simple, instant effect, without any side effects, treating both the principal and secondary aspects of a disease, clinic wide popularization and application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Treat a preparation method for the Chinese medicine preparation of gout, comprise following processing step:
(1) Herba Menthae, Flos jasmini, fevervine, Rhizoma Paridis, Semen Plantaginis, the Radix Astragali, Herba Aconiti Ochranthi, Rhizoma Ligustici, Radix Paeoniae Alba and Herba Scutellariae Barbatae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) river cypress, Radix Saposhnikoviae and fructus amomi are put into pot yellow wine sprinkle to mix thoroughly, then fry with slow fire, take out after fried dry, grind into powder, cross 200 order fine powders, for subsequent use;
(3) cleaned by Herba Oenanthes Javanicae, put shady and cool place and dry, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) after Rhizoma Corydalis Decumbentis and Radix Puerariae being dried, put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), juice and fine powder mixing, make tablet, obtain the Chinese medicine preparation for the treatment of gout of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of gout, select the routine clinical observation of patient with gout 200 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 100 example, wherein male 49 example, women 51 example, 35 ~ 60 years old age, 53.5 years old mean age, the shortest person of the course of disease 3 months, most elder 6 years, average 3.1 years.Matched group 100 example, wherein male 50 example, women 50 example, 33 ~ 61 years old age, 51.3 years old mean age, the shortest person of the course of disease 4 months, most elder 7 years, average 3.5 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, taking 2 ~ 3 courses for the treatment of continuously can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes diclofenac sodium enteric-coated tablets, each 75 ~ 150mg, 1 time weekly, is used in conjunction 2 times; Within 20 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, 2 ~ 3 courses for the treatment of of severe one, the person of being in a bad way is usually invalid.
3, efficacy determination:
(1) cure: the transference cure such as red, swollen, hot, to have an intense pain, local inflammation elimination, joint motion freely.
(2) effective: above-mentioned symptom obviously alleviates, joint motion is clearly better.
(3) effective: above-mentioned symptom is alleviated to some extent, and joint motion makes moderate progress.
(4) invalid: clinical symptoms is not improved.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 60 examples, effective 20 examples, effective 16 examples, invalid 4 examples, cure rate 60%, total effective rate 96%.
11 examples are cured, effective 20 examples, effective 21 examples, invalid 48 examples, cure rate 11%, total effective rate 52% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Cai, man, 38 years old, people from Huaian, Jiangsu.Patient has clear and definite gout medical history, left knee joint skin temperature significantly raises, whole arthroncus, pressing synovial bursae has fluctuation, cold weather just occurs that left knee joint has an intense pain, enlargement, can not bend and stretch, be admitted to hospital the uric acid 620umol/l that has a blood test, erythrocyte sedimentation rate 53mm/h, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention for the state of an illness, arthralgia significantly takes a turn for the better, and does not look into and sees arthroedema, bend and stretch function substantially not limited, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention continuously, symptom disappears completely, and indices has recovered normal.
2, Jiang, man, 45 years old, people from Shenyang, Liaoning.The right ankle joint of patient swells and ache, and removes hospital admission, finds micro-swollen, the pain of right ankle joint, activity slightly feel inconvenience, right foot step on hard object time the pain increased, local slight fever, local skin is dark red, the pain of pressure, and it is slightly high that Pi Wen is comparatively good for side, is diagnosed as gout.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, right ankle joint swells and ache and obviously disappears, and after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, right ankle joint swells and ache and disappears completely, follows up a case by regular visits to and do not recur after 1 year.
3, certain is gone into business, female, 60 years old, Taizhou of Zhejiang people.The left ankle joint of patient congestion and swelling pain repeatedly, goes hospital diagnosis to be gout, and after namely taking western medicine tablet treatment, pain is alleviated to some extent, the normal recurrent exerbation of posterior joint pain.To our hospital, take Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, the state of an illness is alleviated to some extent, and after taking 2 courses for the treatment of, the state of an illness is progressively alleviated, improvement, follows up a case by regular visits to and does not recur so far.