CN103705638A - Traditional Chinese medicine composition for relieving asthenopia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for relieving asthenopia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for relieving asthenopia and a preparation method thereof. The composition is prepared from medicinal materials of panaxadiol saponins, cassia twig, angelica sinensis, astragalus membranaceus, peach kernel, ligusticum wallichii, radix angelicae, wolfberry, semen cuscutae, earthworm and the like. The invention also provides the preparation method for the traditional Chinese medicine composition for relieving asthenopia. The traditional Chinese medicine composition can effectively improve asthenopia and distant vision as well as photopic vision persistence, and realizes the function of relieving asthenopia.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof.
Background technology
Asthenopia is the common a kind of disease of current ophthalmology, and patient's symptom is varied, and common are near work can not be lasting, go out to lose face and eye socket around pain, blurred vision, eyes dry and astringent, shed tears etc., severe patient headache, feel sick, dizzy.It is not disease independently, but the one group of fatigue syndrome causing due to a variety of causes.Its occurrence cause is also diversified, common are: (l) reason of eyes itself, as the ametropia such as myopia, hypermetropia, astigmatism, adjusting factor, eye muscle factor, conjunctivitis, keratitis, wear glasses improper etc.; (2) systemic factor, as neurasthenia, health overwork, hysteria or involutional women; (3) environmental factors, as not enough in illumination or excessively strong, distribution of light sources is inhomogeneous or glimpse, and the target of watching attentively is too small, meticulous or unstable etc.
Increasing " asthenopia " crowd's generation now, is also that modern way of life changes and the performance of social progress, its real reason be people to eyes, the attention to self health.Expert claims, under normal circumstances, intra tear can form a skim to people, covers the surface of Cornea and conjunctiva, is called tear film.People, after each nictation, can form one deck tear film, can keep eyes moistening and comfortable, is therefore difficult for producing the symptoms such as dry, tired.If but stare at for a long time a target (as used computer, reading), and the persistent period is oversize, and winking reflex is fewer, can not form in time tear film, will cause a dry tack free, causes asthenopia.Collyrium can not effect a radical cure eyestrain, although some collyrium really can fatigue alleviating symptom.
Then collyrium is can only respite vision tired, cures the symptoms, not the disease.. alleviating asthenopic collyrium must use under physician guidance.Because all contain antiseptic in current 90% collyrium, these materials can produce infringement to the cell of ocular surface.Patients with dry eye is preferably selected the artificial tears of preservative free.From traditional Chinese medical science angle, asthenopia majority is by deficiency of qi and blood, and order apoplex involving the channels and collaterals is not smooth, loses due to moisten and support.
Summary of the invention
The Chinese medicine composition that the object of this invention is to provide a kind of alleviating asthenopia;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of alleviating asthenopia.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition of alleviating asthenopia of the present invention is to be prepared from by the raw material containing following weight portion:
Panoxadiol's glycosides 1-4 part, Ramulus Cinnamomi 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Astragali 10-30 part, Radix Angelicae Dahuricae 20-40 part, Semen Cuscutae 20-40 part, Pheretima 20-40 part, Semen Persicae 30-50 part, Rhizoma Chuanxiong 30-50 part, Fructus Lycii 30-50 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Panoxadiol's glycosides 2-3 part, Ramulus Cinnamomi 8-12 part, Radix Angelicae Sinensis 8-12 part, Radix Astragali 15-25 part, Radix Angelicae Dahuricae 25-35 part, Semen Cuscutae 25-35 part, Pheretima 25-35 part, Semen Persicae 35-45 part, Rhizoma Chuanxiong 35-45 part, Fructus Lycii 35-45 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
3 parts of panoxadiol's glycosides, 10 parts of Ramulus Cinnamomi, 10 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Semen Cuscutae, 30 parts of Pheretimas, 40 parts, Semen Persicae, 40 parts of Rhizoma Chuanxiongs, 40 parts of Fructus Lyciis.
Below crude drug source of the present invention:
Panaxadiol saponin: be a kind of of ginsenoside.Ginsenoside (Ginsenoside) is a kind of steroid compound, triterpene saponin.Mainly be present in Araliaceae Panax medical material, Panax's majority is some rare Chinese medicines, as Radix Notoginseng, Radix Ginseng, Radix Panacis Quinquefolii etc.Ginsenoside can be divided into three groups of two classes according to the difference of sapogenin, and a class is the Dammar methane series saponin of tetracyclic triterpene, and wherein one group of acid hydrolysis end product is panoxadiol, as ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 etc.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.[nature and flavor] acrid, sweet, warm.[return through] GUIXIN, lung, urinary bladder channel.[function cures mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Angelicae Sinensis: this product is umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels.Autumn end excavates, and removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with pyrotechnics smoke-dried beancurd slowly.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] enriched blood and invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The Radix Astragali: be leguminous plant Radix Astagali Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalus membranaceus(Fisch.) dry root of Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Semen Persicae: this product is rosaceous plant Fructus Persicae Prunus persica(L.) Batsch or Prunus davidiana Prunus davidiana(Carr.) dry mature seed of Franch..After fruit maturation, gather, remove sarcocarp and nucleocapsid, take out seed, dry.[nature and flavor] bitter, sweet, flat.[return through] GUIXIN, liver, large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Rhizoma Chuanxiong: this product is samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichiiFranch.) dry rhizome.Summer, the joint dish on the stem showed outstanding, and slightly excavated during purple, removed silt, and after shining, a heatable brick bed is dry, then removes fibrous root.[nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Angelicae Dahuricae: this product is the plant Radix Angelicae Dahuricae Angelica dahurica(Fisch.ex Hoffm. of umbellate form section) Benth.et Hook.f. or Radix angelicae dahuricae Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana(Boiss.) dry root of Shan et Yuan.When leaf is yellow between summer, autumn, excavate, remove fibrous root and silt, dry or cold drying.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, autumn gathered when two seasons, fruit took on a red color, and hot-air seasoning, removes carpopodium.Or dry in the air to rhicnosis, dry, remove carpopodium.[nature and flavor] are sweet, flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..The plant of gathering during fruit maturation autumn, dries, and lays seed, removes impurity.[nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Pheretima: the animal Pheretima aspergillum Pheretima aspergillum(E.Perrier of this product Wei Ju earthworm section), popular Pheretimatschiliensis Pheretima vulgaris Chen, William Pheretimatschiliensis Pheretima guillelmi(Michaelsen) or the dry body of the blind Pheretimatschiliensis Pheretima of comb pectinifera Michaelsen.Front a kind of habit claims " LUMBRICUS ", practises title " Shanghai Pheretima " for latter three kinds.LUMBRICUS catches to autumn spring, and Shanghai Pheretima catches summer, cuts in time abdominal part open, removes internal organs and silt, cleans, and dries or cold drying.[nature and flavor] are salty, cold.[return through] returns liver, spleen, urinary bladder channel.[function cures mainly] heat clearing away arresting convulsion, dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, and each extraction time is 1-3 hour, and merge extractive liquid, filters, and filtrate is condensed into fluid extract, obtains described active component.
Scheme two: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, and standing 12-24 hour filters, filtrate is condensed into fluid extract, obtains described active component.
Scheme three: get whole medical materials, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 1-3 hour to the 4-10 that each ethanol consumption is medical material total amount, and merge extractive liquid,, filters, and filtrate is condensed into fluid extract, obtains described active component.
The Chinese medicine composition of alleviating asthenopia of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add granule to commonly use adjuvant, production method is prepared into granule of the present invention routinely.
The conventional adjuvant of above-mentioned granule comprises one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
Side separates: we's card is by deficiency of qi and blood, and order apoplex involving the channels and collaterals is not smooth, loses due to moisten and support.Disease opinion is watching for a long time closely, cardiopalmus, forgetful, Mental fatigue etc.Control and work as benefiting vital QI and blood, promoting blood circulation to remove obstruction in the collateral.We's Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, a surname leads the product of invigorating blood circulation and blood stasis dispelling again; Chinese angelica blood supplementing is invigorated blood circulation, and both the virtual loss of YIN nourishing blood, invigorated blood circulation again and help dredging collateral, and two arrogate to oneself its merit; We reuse Radix Astragali QI invigorating, are intended to make the prosperous blood of gas, and stasis of blood Xiaoluotong is all monarch drug.Semen Persicae, Rhizoma Chuanxiong share blood-activating and qi-promoting, regulating menstruation, and association's Radix Angelicae Sinensis activating blood circulation and dissipating blood stasis, helps again Ramulus Cinnamomi bar to reach passages through which vital energy circulates; The pungent row temperature of the Radix Angelicae Dahuricae is logical, is apt to away Yangming Channel, separates head's pain, is all ministerial drug.We assistant is with Fructus Lycii, Semen Cuscutae, Pheretima, and Fructus Lycii and Semen Cuscutae master enter liver, kidney channel, the moon that can nourish liver and kidney, and flat the kidney invigorating essence liver blood, kindly controls visual deterioration due to asthenia of essence and blood, has a dizzy spell; Pheretima master returns Liver Channel, and property is walked to alter, and is longer than current meridians, can fluent blood vessels and help Radix Angelicae Sinensis, Radix Astragali blood-activating and qi-promoting, and make not smooth venation QI and blood full.
The present invention adds panoxadiol's glycosides in above-mentioned side.Panoxadiol's glycosides has the microcirculatory effect of improvement, thereby improves the confession of eye blood, improves eye metaboilic level, and the effect of its antioxidation, removing free radical also has protection to eyes.Panoxadiol's glycosides also has neuroprotective simultaneously, can play protection to optic nerve.Above-mentioned side assists with panoxadiol's glycosides, its alleviating asthenopia, and the health care of protection eyes is better.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
The Chinese medicine composition of a kind of alleviating asthenopia provided by the invention has the following advantages:
1, the Chinese medicine composition of alleviating asthenopia provided by the invention is invigorated blood circulation by dredging collateral, and blood yiqi is alleviating asthenopia fundamentally., can improve the asthenopic symptom of experimenter, the present invention compares with matched group, and its function of improving asthenopia symptom is more excellent, is significantly better than matched group (P < 0.05).
2, the present invention can improve experimenter's distant vision, compares have significant difference (P < 0.05) with matched group, shows that test group is better to asthenopia experimenter's function.
3, Chinese medicine composition of the present invention can make the average duration of photopic vision of experimenter improve and be greater than 10%, compare with matched group, duration of photopic vision of the present invention is higher, two groups have significant difference (P < 0.05), show that medicine of the present invention has the function of better raising duration of photopic vision.。
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
Embodiment 1 syrup
Get panoxadiol's glycosides 3g, Ramulus Cinnamomi 10g, Radix Angelicae Sinensis 10g part, Radix Astragali 20g, Radix Angelicae Dahuricae 30g, Semen Cuscutae 30g, Pheretima 30g, Semen Persicae 40g, Rhizoma Chuanxiong 40g, Fructus Lycii 40g.By above-mentioned whole medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, and merge extractive liquid, filters, and filtrate is condensed into fluid extract.In extractum, add syrup adjuvant sucrose, Mel, potassium sorbate, water to stir, make syrup.
Embodiment 2 tablets
Get panoxadiol's glycosides 2g, Ramulus Cinnamomi 8g, Radix Angelicae Sinensis 8g part, Radix Astragali 15g, Radix Angelicae Dahuricae 25g, Semen Cuscutae 25g, Pheretima 25g, Semen Persicae 350g, Rhizoma Chuanxiong 35g, Fructus Lycii 35g.By above-mentioned whole medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 3 mixture
Get panoxadiol's glycosides 3g, Ramulus Cinnamomi 12g, Radix Angelicae Sinensis 12g part, Radix Astragali 25g, Radix Angelicae Dahuricae 35g, Semen Cuscutae 35g, Pheretima 35g, Semen Persicae 45g, Rhizoma Chuanxiong 45g, Fructus Lycii 45g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filters, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.20, adds ethanol, and making containing alcohol amount is 40%, standing 24 hours, filter, filtrate is condensed into fluid extract, and adding purified water ad pond om is 3 times of medical material gross weight, fill, obtains mixture of the present invention.
Add mixture adjuvant sucrose, ethyl ester, water, potassium sorbate to stir, make mixture.
Embodiment 4 tablets
Get panoxadiol's glycosides 1g, Ramulus Cinnamomi 5g, Radix Angelicae Sinensis 5g part, Radix Astragali 10g, Radix Angelicae Dahuricae 20g, Semen Cuscutae 20g, Pheretima 20g, Semen Persicae 30g, Rhizoma Chuanxiong 30g, Fructus Lycii 30g.By above-mentioned whole medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, and merge extractive liquid, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, micropowder silica gel, make tablet.
Embodiment 5 capsules
Get panoxadiol's glycosides 4g, Ramulus Cinnamomi 15g, Radix Angelicae Sinensis 15g part, Radix Astragali 30g, Radix Angelicae Dahuricae 40g, Semen Cuscutae 40g, Pheretima 40g, Semen Persicae 50g, Rhizoma Chuanxiong 50g, Fructus Lycii 50g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, and merge extractive liquid, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 6 granules
Get panoxadiol's glycosides 1g, Ramulus Cinnamomi 10g, Radix Angelicae Sinensis 5g part, Radix Astragali 15g, Radix Angelicae Dahuricae 30g, Semen Cuscutae 20g, Pheretima 35g, Semen Persicae 30g, Rhizoma Chuanxiong 40g, Fructus Lycii 45g.By above-mentioned whole medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, and merge extractive liquid, filters, filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, adds ethanol, and making containing alcohol amount is 70%, standing 12 hours, filter, filtrate is condensed into after fluid extract, is dried to dried cream powder, add adjuvant Icing Sugar, starch, dextrin, ethanol, make granule.
Embodiment 7 powder
Take panoxadiol's glycosides 4g, Ramulus Cinnamomi 12g, Radix Angelicae Sinensis 15g part, Radix Astragali 25g, Radix Angelicae Dahuricae 20g, Semen Cuscutae 25g, Pheretima 20g, Semen Persicae 40g, Rhizoma Chuanxiong 50g, Fructus Lycii 35g.Medical material cleans, pulverizes, and crosses 80-100 mesh sieve, obtains powder of the present invention.
Pharmacodynamics test: improve the evaluation of asthenopia function assessment
Human feeding trial:
By investigation, take sample of the present invention front and back to the asthenopic impact of experimenter, the present invention is improved to asthenopic health care and carry out function assessment evaluation.
1 experimenter includes in and exclusion standard
(check of < < health food and the assessment technique enforcement of regulations handbook > > that with reference to Ministry of Public Health, issue)
1.1 experimenter's inclusive criterias
1.1.1 children and adolescents or adult.
1.1.2 long-term with eye, vision fatiguability person.
1.2 experimenter's exclusion standards
1.2.1 do not meet the experimenter who includes age criterion in; To health food allergy sufferers.
1.2.2 suffers from infectious ocular disease person, the inside and outside eye disease patients such as corneal nebula, circle Phasiana cornea.
1.2.3 suffer from fundus oculi disease or be associated with the diseases such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system.
1.2.4 take in a short time the article relevant with tested function, have influence on the judgement person to result.
1.2.5 medicine of other relevant treatment vision of long-term taking or use other Therapeutic Method, fails terminator.
1.2.6 do not meet inclusive criteria, do not take in accordance with regulations, or data is not congruent affects effect or safety judgement person.
1.3 observation index
1.3.1 safety indexes
1.3.1.1 blood, routine urianlysis, physical examination.
1.3.1.2 liver, kidney function test (child experimenter does not measure this).
1.3.1.3 Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection (in pretest inspection once, child experimenter does not measure this).
1.3.2 efficiency index while finishing (in on-test and check)
1.3.2.1 ophthalmologic examination, ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, the symptom such as dry and astringent.
1.3.2.2 duration of photopic vision: assay method is shown in the check of < < health food and assessment technique enforcement of regulations handbook > > appendix.
1.3.2.3 distant vision.
1.4 asthenopia symptom decision methods, in Table 1
Table 1 asthenopia symptom decision method (sxemiquantitative integration method)
Note: " random thoughts " refer to 1-2 time/2 days; " time have " refers to 1-3 times/day; " often " refers to >3 times/day
1.5 date processing and statistical analysis
By the data input database that experimental period is collected, analyze and statistical procedures.Symptom integral and duration of photopic vision are measurement data, and improvement rate and total effective rate are enumeration data, adopt respectively t check and check to carry out Χ
2relatively.All take the standard that P<0.05 or P<0.01 be its significance of difference.
2 case selections and grouping
At 20～40 years old age, long-term with eye, asthenopia, is ready to accept 30 days experimenters.Adopt two kinds of control design between self and group.According to symptom and examination of visual acuity situation, consider the factors such as age, sex simultaneously, by random, double-blind method, be divided into test group and matched group, every group of number 102 people.
3 give quadrat method
Experimental group: give embodiment 1 syrup, each 10ml, every day 2 times.
Matched group: give QIJU DIHUANG KOUFUYE, Beijing Changcheng Pharmaceutical Factory produces, each 10ml, every day 2 times.
4 effect criterion
4.1 the symptoms of eye diseases
Symptom is improved: ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, the dry and astringent arbitrary symptom improvement of eye are improvement for 1 minute and 1 minute above, and 5 kinds of arbitrary improvement of symptom and other symptoms judge symptom improvement without worsening.
Effective: before and after symptom improvement and duration of photopic vision, differ by more than and equal 0.1, and comparing difference to have significance by statistics.
Invalid: not reach effective standard.
4.2 durations of photopic vision: average duration of photopic vision raising is more than or equal to 10%.
4.3 distant vision: eye vision contrast before and after test.
5 results
The symptoms such as experimental group most of patient take after the embodiment of the present invention 1, and ophthalmalgia, ophthalmic bloated, photophobia, blurred vision, eye are dry and astringent have obtained improvement in various degree.
The impact of table 2 test sample on experimenter's asthenopia symptom
Note: test group is compared with matched group, * P < 0.05.
As shown in Table 2, test group and the asthenopic symptom of matched group experimenter have all obtained good improvement.Test group is compared with matched group, and its function of improving asthenopia symptom is more excellent, is significantly better than matched group (P < 0.05).
Table 3 test sample on the impact of experimenter's distant vision (n=102,
± s)
Note: test group is compared with matched group, * P < 0.05.
As shown in Table 3, tested after, test group distant vision improves obviously, compares have significant difference (P < 0.05) with matched group.Show that test group is better to asthenopia experimenter's health care.
Table 4 test sample on the impact of experimenter's duration of photopic vision (n=102,
± s)
Note: test group is compared with matched group, * P < 0.05.
As shown in Table 4, test group and matched group experimenter test rear average duration of photopic vision raising and are all greater than 10%, think that two groups of durations of photopic vision are all improved.But test group is compared with matched group, the duration of photopic vision of test group is higher, and two groups have significant difference (P < 0.05).Show that health product of the present invention have the function of better raising duration of photopic vision.
Conclusion: medicine of the present invention can effectively improve asthenopia symptom, improves distant vision, and improve duration of photopic vision, reach the effect of alleviating asthenopia.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. a Chinese medicine composition for alleviating asthenopia, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: panoxadiol's glycosides 1-4 part, Ramulus Cinnamomi 5-15 part, Radix Angelicae Sinensis 5-15 part, Radix Astragali 10-30 part, Radix Angelicae Dahuricae 20-40 part, Semen Cuscutae 20-40 part, Pheretima 20-40 part, Semen Persicae 30-50 part, Rhizoma Chuanxiong 30-50 part, Fructus Lycii 30-50 part.
2. the Chinese medicine composition of alleviating asthenopia as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: panoxadiol's glycosides 2-3 part, Ramulus Cinnamomi 8-12 part, Radix Angelicae Sinensis 8-12 part, Radix Astragali 15-25 part, Radix Angelicae Dahuricae 25-35 part, Semen Cuscutae 25-35 part, Pheretima 25-35 part, Semen Persicae 35-45 part, Rhizoma Chuanxiong 35-45 part, Fructus Lycii 35-45 part.
3. the Chinese medicine composition of alleviating asthenopia as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 3 parts of panoxadiol's glycosides, 10 parts of Ramulus Cinnamomi, 10 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Semen Cuscutae, 30 parts of Pheretimas, 40 parts, Semen Persicae, 40 parts of Rhizoma Chuanxiongs, 40 parts of Fructus Lyciis.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, standing 12-24 hour, filter, filtrate is condensed into fluid extract, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
8. a Chinese medicine composition for alleviating asthenopia, comprises acceptable carrier in the Chinese medicine composition of the alleviating asthenopia of any one in claim 1-3 and pharmaceuticals industry.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688931A (en) * | 2015-04-02 | 2015-06-10 | 张玉雯 | Medicine composition for relieving eyestrain and preparation method of medicine composition |
| CN105535258A (en) * | 2015-12-24 | 2016-05-04 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation for regulating asthenopia |
| CN106344878A (en) * | 2016-10-25 | 2017-01-25 | 广西壮族自治区职业病防治研究院 | Zhuang medicine composition for treating asthenopia caused by view screen |
| CN110179966A (en) * | 2019-05-17 | 2019-08-30 | 严启新 | The preparation method and applications of traditional Chinese medicine composition for relieving asthenopia |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279008A (en) * | 2007-04-05 | 2008-10-08 | 北京华恒汉方医药科技有限公司 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
| CN101642511A (en) * | 2009-09-07 | 2010-02-10 | 林继华 | Traditional Chinese medicine composition for relieving visual fatigue and treating pseudomyopia and preparation method thereof |
| CN103417737A (en) * | 2013-08-12 | 2013-12-04 | 东北师范大学 | Eye protection liquid with ginsenoside Rg1 |
-
2013
- 2013-12-30 CN CN201310744525.1A patent/CN103705638B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279008A (en) * | 2007-04-05 | 2008-10-08 | 北京华恒汉方医药科技有限公司 | Chinese medicine pad pasting for preventing and controlling myopic eye, eyestrain symptoms and eyebase ischemia |
| CN101642511A (en) * | 2009-09-07 | 2010-02-10 | 林继华 | Traditional Chinese medicine composition for relieving visual fatigue and treating pseudomyopia and preparation method thereof |
| CN103417737A (en) * | 2013-08-12 | 2013-12-04 | 东北师范大学 | Eye protection liquid with ginsenoside Rg1 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688931A (en) * | 2015-04-02 | 2015-06-10 | 张玉雯 | Medicine composition for relieving eyestrain and preparation method of medicine composition |
| CN105535258A (en) * | 2015-12-24 | 2016-05-04 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation for regulating asthenopia |
| CN106344878A (en) * | 2016-10-25 | 2017-01-25 | 广西壮族自治区职业病防治研究院 | Zhuang medicine composition for treating asthenopia caused by view screen |
| CN110179966A (en) * | 2019-05-17 | 2019-08-30 | 严启新 | The preparation method and applications of traditional Chinese medicine composition for relieving asthenopia |
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| CN103705638B (en) | 2016-05-18 |
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