CN101947303B - Drug for radical treatment of hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for radical treatment of hypertension and a preparation method thereof. The drug is prepared from red flower, peach kernel, motherwort, rhizoma sparganii, curcuma zedoary, green tangerine peel and frankincense at a certain weight ratio. The drug can be prepared into any common oral administration agent. The drug of the invention has the functions of removing pathogenic heat from blood, tonifying qi and yin, drying dampness and strengthening the spleen, can be used for treating hypertension and has high curative effect and high cure rate.

Description

Hypertensive medicine of a kind of radical cure and preparation method thereof

Technical field

The present invention relates to hypertensive medicine of a kind of radical cure and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Hypertension is common cardiovascular disease, is that to increase with the systemic arterial blood pressure persistence be the clinical syndrome of main performance, is divided into essential hypertension and secondary hypertension.With the increase of operating pressure, hypertension has become a kind of commonly encountered diseases and frequently-occurring disease with the quickening pace of modern life.During morbidity, the headache position is many at hindbrain, and with feel sick, symptom such as vomiting.Symptoms such as that the patient can occur is dizzy, tinnitus, shortness of breath and palpitation, insomnia and numb limbs and tense tendons in case morbidity is taken medicine throughout one's life, cause great harm and misery for people's physical and mental health.Modern medicine is treated hypertensive principle, adopts oral western medicine blood pressure lowering therapy.Western medicine can only be alleviated hyperpietic's the state of an illness, can not eradicate, in case patient's drug withdrawal, blood pressure promptly gos up, and the control hypertension of not adhering to taking medicine causes diseases such as the heart, brain, kidney easily.

Summary of the invention

Therefore there is great demand in people to eutherapeutic Chinese medicine, up to now, also do not find the relevant report of relevant medicine of the present invention, pathogenesis through investigating this sick subordination traditional Chinese medical science is a deficiency in origin and excess in superficiality, with deficiecny of liver-YIN, it originally is main that excessive rising of liver-YANG or damage of kidney-YIN, water are not contained at this, be marked with fire flaming up due to disorder of QI, fire is contained pneumatic or hyperactive liver-YANG causing syndrome of liver-wind is main.

The inventor is according to above-mentioned theory, and through research and clinical trial repeatedly, having found finally has the hypertensive medicine of the quick-acting radical cures of better curative effect, thereby has finished the present invention.

Purpose of the present invention just provides the hypertensive composition of medicine of a kind of quick-acting radical cure.

Another object of the present invention has just provided this composition of medicine preparation method.

Medicament selection Flos Carthami of the present invention, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, the 36-flavor Glutinous medicine of Poria cum Radix Pini makes up, make each efficacy of drugs produce synergism these drug regimens, thereby can the hypertensive recurrence of effective quick-acting radical cures, wherein selecting Flos Carthami for use is because of its nature and flavor suffering, temperature.Go into the heart, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, and blood stasis removing analgesic function is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, traumatic injury.Select for use Semen Persicae to be because its property bitter but sweet flavor is flat.Go into the heart, liver, large intestine channel.Blood stasis removing and clots absorbing is arranged, moisturize the function of laxation, control amenorrhea ， mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select for use Herba Leonuri to be because its nature and flavor are arduous, cold.Go into pericardium, Liver Channel.Invigorate blood circulation blood stasis dispelling, regulating menstruation, the function of the water that disappears.Control menoxenia, the vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria is rushed down blood, the carbuncle skin infection.Select for use rhizoma sparganic to be because its nature and flavor toil is flat, go into liver, spleen channel, removing blood stasis is arranged, circulation of qi promoting, removing food stagnancy, analgesic function ， Zhi lumps in the chest and abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body expands painful down, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer is swollen hard.Selecting Rhizoma Curcumae for use is because of its nature and flavor suffering, hardship, temperature, returns liver, spleen channel, the circulation of qi promoting removing blood stasis is arranged, removing food stagnancy analgesic function ， Zhi mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma.Select Radix Rehmanniae for use, the different name Radix Rehmanniae, Radix Rehmanniae, its nature and flavor sweetness and bitterness, cold is gone into the heart, liver, kidney channel, and heat clearing away is arranged, removing heat from blood, the function of promoting the production of body fluid is controlled the epidemic febrile disease impairment of YIN, big hot excessive thirst, crimson tongue, coma, macule is spitted blood, epistaxis, the asthenia hectic fever due to YIN-deficiency, hemoptysis is quenched one's thirst, constipation, metrorrhagia.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Select for use Fructus Lycii to be because its nature and flavor are sweet, flat, go into liver, kidney channel, nourishing kidney is arranged, lung moistening, the function that makes eye bright, the treating the liver kidney yin is lost, soreness of the waist and knees, dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease is quenched one's thirst, seminal emission.Select for use Semen Plantaginis to be because its nature and flavor are sweet, cold, go into kidney, urinary bladder channel has diuretic, and heat clearing away makes eye bright, and the expectorant function is controlled dysuria, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Radix Notoginseng for use, different name mountain lacquer, Herba Wedeliae Wallichii, Radix Notoginseng, its property sweet and slightly bitter taste, temperature is gone into liver, stomach, large intestine channel.Hemostasis is arranged, dissipating blood stasis, detumescence, the function of analgesic therapy is controlled haematemesis, hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia ， mass in the abdomen, puerperal blood faints, retention of lochia, traumatic injury blood stasis, traumatic hemorrhage, carbuncle pain.Select for use Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating middle warmer is arranged, QI invigorating, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of loosening bowel to relieve constipation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, traumatic injury.Select for use Radix Cyathulae to be because its nature and flavor are flat, sweet and slightly bitter taste, nontoxic, go into liver, kidney two warps, dispel the wind, dampness removing stimulates the menstrual flow, the function of invigorating blood circulation, dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen.Selecting Fructus Amomi for use is that temperature is gone into spleen, stomach warp because of its nature and flavor suffering, have in the circulation of qi promoting accent, and stomach function regulating, the function of being amusing is controlled the stomachache painful abdominal mass and is expanded anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Selecting the Radix Paeoniae Alba for use is that liver, spleen channel are gone in cold, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select for use Fructus Crataegi to be because its nature and flavor acid is sweet, tepor is gone into spleen, stomach, Liver Channel, has to help digestion long-pendingly, and dissipating blood stasis blood drives the function of edge worm, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.Select for use Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste is flat, go into the heart, Liver Channel, nourish heart, calm the nerves, collateral dredging, the function of dispeling the wind is controlled insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Select for use Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, go into the heart, spleen, liver, gallbladder meridian, nourishing the liver is arranged, mind calming is calmed the nerves, and the function of arresting sweating is controlled restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select for use Cortex Moutan to be because its nature and flavor are arduous, cool, go into the heart, liver, kidney channel, heat clearing away is arranged, removing heat from blood, and blood, the function of repercussive is controlled the pathogenic heat attacking blood system in febrile diseases, sends out speckle, and infantile convulsion is told, is defeated in battle, is had blood in stool, the hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer is pounced on damage.Select for use Os Draconis to be because its property sweet-puckery flavor is flat, go into the heart, liver, kidney, large intestine channel, tranquillizing the mind by relieving convulsion is arranged, the arresting sweating controlling nocturnal emission with astringent drugs, the hemostasis astringing intestine to stop diarrhea, life is held back the function of skin ulcer.It is demented to control infantile convulsion, and severe palpitation is forgetful, insomnia and dreamful sleep, and spontaneous sweating, the seminal emission stranguria with turbid discharge is told nosebleed and is had blood in stool, bleeding not during menses, the dysentery proctoptosis, ulcer does not close up for a long time.Select for use Concha Ostreae to be because its nature and flavor are salty and bitter, liver, kidney channel are gone in cold, and yin fluid astringing is arranged, the resistance of diving, and hidroschesis, arresting seminal emission reduces phlegm, and the function of softening the hard mass is controlled infantile convulsion, and is dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.It is salty because of its nature and flavor, cold, slightly poisonous selecting Eupolyphaga Seu Steleophaga for use, returns Liver Channel, and removing blood stasis with potent drugs blood is arranged, and the function of reuniting the fractured tendons and bones is controlled the muscles and bones folding and hindered blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select for use Radix Aristolochiae to be because its nature and flavor are arduous, cold, go into lung, stomach warp, circulation of qi promoting is arranged, detoxifcation, the repercussive function is controlled chest and abdomen swelling and pain, acute filthy disease, the enteritis dysentery, hypertension, hernia, Serpentis stings poison, carbuncle, furuncle, skin pruritus or wet mashed.Selecting Pericarpium Citri Reticulatae for use is because of its nature and flavor suffering, hardship, temperature.Go into spleen, lung meridian, regulate the flow of vital energy, in the accent, dampness is reduced phlegm.Control distension and fullness of the chest and abdomen, anorexia vomiting hiccup, cough with copious phlegm.Select for use Rhizoma Cyperi to be because the hot little hardship of its nature and flavor is sweet, flat, go into liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Selecting Pericarpium Citri Reticulatae Viride for use is because of its nature and flavor toil, tepor, goes into liver, gallbladder meridian, and soothing the liver dispelling the stagnated QI is arranged, and the function of eliminating stagnation expectorant is controlled breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction piece.Select for use Olibanum to be because its nature and flavor are arduous, temperature is gone into the heart, liver, spleen channel.Regulating qi and activating blood is arranged, and analgesic therapy chases after malicious function, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select for use Myrrha to be because its nature and flavor hardship is flat, go into Liver Channel, diffusing blood blood stasis removing is arranged, the function of subduing swelling and relieving pain is controlled and is fallen damage, incised wound, muscles and bones, all Tong ， of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.It is sweet because of its nature and flavor, cold selecting Cortex Lycii for use, goes into lung, liver, kidney channel, and heat clearing away is arranged, and the function of removing heat from blood is controlled asthenia hectic fever night sweat, and the lung-heat cough with asthma is spitted blood, epistaxis, and stranguria with blood is quenched one's thirst, hypertension, pain is swollen, malignant boil.Select for use Herba Artemisiae Annuae to be because the bitter little suffering of its nature and flavor is cold, go into liver, gallbladder meridian, heat clearing away is arranged, expelling summer-heat removes the function of steaming, and controls epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, malaria, dysentery, jaundice, scabies, pruritus.Select for use Radix Paeoniae Rubra to be because of its nature and flavor hardship, to be slightly cold, go into Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain is controlled maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, injury from falling down, carbuncle skin infection.Selecting Radix Panacis Quinquefolii for use is that the heart, lung, kidney three warps are gone in cold because of its property sweet and slightly bitter taste.Useful lung yin, clear asthenic fire, the function of promoting the production of body fluid to quench thirst.Control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired tired.Select for use the Radix Astragali to be because sweet, the tepor of its nature and flavor is gone into lung, spleen channel.Control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, and the card of all weakness of QI blood deficiency.It is sweet because of its nature and flavor, cold selecting Flos Lonicerae for use, goes into lung, stomach warp.Heat clearing away is arranged, and the antidotal function is controlled the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select for use Herba Taraxaci to be because its property bitter but sweet flavor is cold, go into liver, stomach warp, heat-clearing and toxic substances removing is arranged, the function of diuresis eliminating stagnation is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select for use Poria cum Radix Pini to be because its nature and flavor are sweet, light, flat, go into the heart, spleen two warps, mind tranquilizing and the heart calming is arranged, the function of diuretic is controlled the palpitation with fear of having a guilty conscience, and is forgetful, insomnia, infantile convulsion, dysuria.

The specific embodiment

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range:

Flos Carthami 10-15 gram Semen Persicaes 10-15 gram Herba Leonuris 15-30 grams

Rhizoma sparganic 10-15 gram Rhizoma Curcumae 10-15 gram Radix Rehmanniae 10-30 grams

Radix Rehmanniae Preparata 10-30 gram Fructus Lycii 10-30 gram Semen Plantaginiss 10-30 grams

Radix Notoginseng 6-15 gram Radix Codonopsis 10-20 gram Radix Angelicae Sinensis 10-20 grams

Radix Cyathulae 10-20 gram Fructus Amomis 10-15 gram Radix Paeoniae Albas 10-20 grams

Fructus Crataegi 10-20 gram Caulis Polygoni Multiflori 10-20 gram Semen Ziziphi Spinosaes 15-30 grams

Cortex Moutan 15-30 cron bones 10-30 gram Concha Ostreaes 10-30 grams

Eupolyphaga Seu Steleophaga 6-12 gram Radix Aristolochiaes 10-15 gram Pericarpium Citri Reticulataes 10-15 grams

Rhizoma Cyperi 10-15 gram Pericarpium Citri Reticulatae Virides 10-15 gram Olibanums 10-15 grams

Myrrha 10-15 gram Cortex Lycii 10-20 gram Herba Artemisiae Annuaes 10-30 grams

Radix Paeoniae Rubra 10-20 gram Radix Panacis Quinquefoliis 3-15 gram Radixs Astragali 10-30 grams

Flos Lonicerae 10-30 gram Herba Taraxacis 10-30 gram Poria cum Radix Pinis 10-20 grams

Be preferably:

Flos Carthami 12 gram Semen Persicaes 12 gram Herba Leonuris 20 grams

Rhizoma sparganic 12 gram Rhizoma Curcumae 12 gram Radix Rehmanniae 20 grams

Radix Rehmanniae Preparata 20 gram Fructus Lycii 20 gram Semen Plantaginiss 20 grams

Radix Notoginseng 8 gram Radix Codonopsis 15 gram Radix Angelicae Sinensis 15 grams

The Radix Cyathulae 15 gram Fructus Amomis 10 gram Radix Paeoniae Albas 15 grams

Fructus Crataegi 15 gram Caulis Polygoni Multiflori 15 gram Semen Ziziphi Spinosaes 20 grams

Cortex Moutan 20 cron bones 20 gram Concha Ostreaes 20 grams

Eupolyphaga Seu Steleophaga 8 gram Radix Aristolochiaes 12 gram Pericarpium Citri Reticulataes 12 grams

Rhizoma Cyperi 12 gram Pericarpium Citri Reticulatae Virides 12 gram Olibanums 12 grams

Myrrha 12 gram Cortex Lycii 15 gram Herba Artemisiae Annuaes 20 grams

The Radix Paeoniae Rubra 15 gram Radix Panacis Quinquefoliis 10 gram Radixs Astragali 20 grams

Flos Lonicerae 20 gram Herba Taraxacis 20 gram Poria cum Radix Pinis 15 grams

Preparation method of the present invention is as follows:

(1) get the raw materials ready:

1, Flos Carthami: choose clean impurity, remove that stem is told, base of a fruit head, dry;

2, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

3, Herba Leonuri: choose decontamination, clean, run through, cutting is dried;

4, rhizoma sparganic: choose decontamination, be soaked in water, pull out and run through, section is dried;

5, Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping is cleaned, and slightly soaks, and takes out, runs through, and shave, drying, sieve removes chip;

6, Radix Rehmanniae: wash earth, remove impurity, cutting;

7, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;

8, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck the residual stalk and the base of a fruit;

9, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

10, Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

11, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

12, Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

13, Radix Cyathulae: get crude drug, remove impurity, clean, run through, go out removing LU, shave, drying, sieve removes chip;

14, Fructus Amomi: remove impurity and shell, smash to pieces;

15, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

16, Fructus Crataegi: choose clean impurity, the sieve enucleation;

17, Caulis Polygoni Multiflori: clear water is cleaned, and soaks slightly, pulls out, and after running through, cutting is dried;

18, Semen Ziziphi Spinosae: former medicine is put into the bamboo square-bottomed bamboo basket; Sink in the clear water cylinder, core is kept afloat, shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;

19, Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;

20, Os Draconis: outwash earth, smash;

21, Concha Ostreae: clean, dry, pulverize usefulness;

22, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

23, Radix Aristolochiae: choose decontamination, separately size bar is soaked in water, and pulls out, and profit is even to inside and outside humidity, section, drying;

24, Pericarpium Citri Reticulatae: brush away earth, choose decontamination, the spray clear water, shredding or section are dried behind the moistening;

25, Rhizoma Cyperi: choose decontamination, grind into particle, winnow with a dustpan fine, soft fur and smalls;

26, Pericarpium Citri Reticulatae Viride: choose decontamination, be soaked in water, pull out, run through, section is dried;

27, Olibanum: choose the sub-impurity of shakeout;

28, Myrrha: choose decontamination, break into fragment;

29, Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting;

30, Herba Artemisiae Annuae: choose decontamination, remove undesirable root, water drenches and makes profit, and cutting is dried;

31, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

32, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days is taken out section, dries;

33, the Radix Astragali: choose decontamination, remove residual root head and hollow the greater, be soaked in water, pull out, run through back section in time, dry;

34, Flos Lonicerae: sieve removes silt, chooses clean impurity;

35, Herba Taraxaci: choose decontamination, clean earth, cutting is dried;

36, Poria cum Radix Pini: get Poria cum Radix Pini's piece or sheet, remove impurity, or get crude drug, remove impurity, clean, run through, be cut into foursquare sheet or piece, dry in the shade.

Two, preparation

1, the preparation of capsule

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini adds decocting twice, each amount of water is advisable to cover powder, intense fire decocts boiling, slow fire boiling 20 minutes, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and be concentrated in 45-50 ℃ of dryings down, it is ground into powder, incapsulates.

2, the preparation of tablet

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, add for the second time 4 times of amounts that water is crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir, precipitation reclaims ethanol and concentrates, and it is dry down at 45-50 ℃, be ground into powder, add the adjuvant compacting in flakes.

3, the preparation of decocting liquid

(1) with the Flos Carthami of described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water, add for the first time 2 times of amounts that water is crude drug weight, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;

(2) medicinal residues after will filtering for the first time add 1.5 times of amounts that water is medicinal residues weight, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient.

4, particulate preparation

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, add for the second time 4 times of amounts that water is crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir, precipitation reclaims ethanol and concentrates, dry down at 45-50 ℃, add adjuvant, become granule.

5, the preparation of unguentum

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, 4 times of amounts that add for the second time water crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum.

The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as tablet, capsule, oral liquid, granule, unguentum etc.

Medicine of the present invention has promoting blood circulation and breaking stagnation, clearing away heat and cooling blood, nourishing blood and hemoslasis, supplementing QI and nourishing YIN, function such as drying damp and strengthening spleen, is used for the treatment of hypertension, and curative effect is fast, and easily radical cure is not recurred.

Below further set forth effective achievement of medicine of the present invention by testing example, these tests comprise that medicine animal toxicity test of the present invention and clinical observation test.

[test example 1] medicine of the present invention is to the toxicity test report of rabbit

Get 40 of West Germany does, body weight 2.0-2.5kg divides two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 15ml/kg, and normal amount is 10ml/kg, and the administration of administering mode administration by gavage once a day, serve on January, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 580 examples for medical treatment, 30-40 years old 80 age example, 40-50 examples, 200 examples are 300 examples more than 50 years old.

2, diagnostic criteria

Light-duty hypertension incidence 1-3 years, low when high during patient's blood pressure, blood pressure 150/90mmhg has slight dizziness, headache, emotional instability, the time bitter taste is arranged, dry pharynx, halitosis, symptoms such as slight insomnia.Heavy hypertension history 3-20 years, patient's complexion is crimson or clear and bright white, and diet is poor, extremity are tired, and top-heavy, dizzy, muddled, headache is accompanied throughout the year, and blood pressure is through being everlasting more than 180/90 mmhg, numb limbs and tense tendons, acid is heavy unable, individual patient and with symptoms such as hemiplegia.

3, Therapeutic Method

1 pair of decocting liquid every day, herbal decoction services once sooner or later routinely, and one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment; Oral three times of tablet every day, each 8, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment; Oral three times of granule every day, month course of treatment of each 1 bag of 12 gram, a light-duty course of treatment, heavy two courses of treatment; Oral three times of unguentum every day, each 20ml, one month is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.

4, efficacy assessment standard

Produce effects: light, heavy hypertension after treatment, patient's transference cure, it is normal that body constitution is recovered, and in normal value, follows up a case by regular visits to 1-5 years no recidivists through blood pressure instrumentation amount.

Take a turn for the better: effect is the same after controlling.

Invalid: as not have invalid case after the treatment

5, therapeutic outcome

In the treatment of a course of treatment, with light-duty hyperpietic's 280 examples of Drug therapy of the present invention, produce effects 280 examples, total effective rate 100% is in the treatment of two courses of treatment, with heavy hyperpietic's 300 examples of Drug therapy of the present invention, produce effects 300 examples, total effective rate are 100%.

Claims (3)

1. one kind is effected a radical cure hypertensive medicine, and it is characterized in that: it is to be made by the crude drug in the following weight range:

Flos Carthami 10-15 gram Semen Persicaes 10-15 gram Herba Leonuris 15-30 grams

Rhizoma sparganic 10-15 gram Rhizoma Curcumae 10-15 gram Radix Rehmanniae 10-30 grams

Radix Rehmanniae Preparata 10-30 gram Fructus Lycii 10-30 gram Semen Plantaginiss 10-30 grams

Radix Notoginseng 6-15 gram Radix Codonopsis 10-20 gram Radix Angelicae Sinensis 10-20 grams

Radix Cyathulae 10-20 gram Fructus Amomis 10-15 gram Radix Paeoniae Albas 10-20 grams

Fructus Crataegi 10-20 gram Caulis Polygoni Multiflori 10-20 gram Semen Ziziphi Spinosaes 15-30 grams

Cortex Moutan 15-30 cron bones 10-30 gram Concha Ostreaes 10-30 grams

Eupolyphaga Seu Steleophaga 6-12 gram Radix Aristolochiaes 10-15 gram Pericarpium Citri Reticulataes 10-15 grams

Rhizoma Cyperi 10-15 gram Pericarpium Citri Reticulatae Virides 10-15 gram Olibanums 10-15 grams

Myrrha 10-15 gram Cortex Lycii 10-20 gram Herba Artemisiae Annuaes 10-30 grams

Radix Paeoniae Rubra 10-20 gram Radix Panacis Quinquefoliis 3-15 gram Radixs Astragali 10-30 grams

Flos Lonicerae 10-30 gram Herba Taraxacis 10-30 gram Poria cum Radix Pinis 10-20 grams.

2. the hypertensive medicine of radical cure according to claim 1, wherein the consumption of each crude drug is:

Flos Carthami 12 gram Semen Persicaes 12 gram Herba Leonuris 20 grams

Rhizoma sparganic 12 gram Rhizoma Curcumae 12 gram Radix Rehmanniae 20 grams

Radix Rehmanniae Preparata 20 gram Fructus Lycii 20 gram Semen Plantaginiss 20 grams

Radix Notoginseng 8 gram Radix Codonopsis 15 gram Radix Angelicae Sinensis 15 grams

The Radix Cyathulae 15 gram Fructus Amomis 10 gram Radix Paeoniae Albas 15 grams

Fructus Crataegi 15 gram Caulis Polygoni Multiflori 15 gram Semen Ziziphi Spinosaes 20 grams

Cortex Moutan 20 cron bones 20 gram Concha Ostreaes 20 grams

Eupolyphaga Seu Steleophaga 8 gram Radix Aristolochiaes 12 gram Pericarpium Citri Reticulataes 12 grams

Rhizoma Cyperi 12 gram Pericarpium Citri Reticulatae Virides 12 gram Olibanums 12 grams

Myrrha 12 gram Cortex Lycii 15 gram Herba Artemisiae Annuaes 20 grams

The Radix Paeoniae Rubra 15 gram Radix Panacis Quinquefoliis 10 gram Radixs Astragali 20 grams

Flos Lonicerae 20 gram Herba Taraxacis 20 gram Poria cum Radix Pinis 15 grams.

3. according to the preparation method of claim 1 or 2 described medicines, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready:

(1) Flos Carthami: choose clean impurity, remove that stem is told, base of a fruit head, dry;

(2) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

(3) Herba Leonuri: choose decontamination, clean, run through, cutting is dried;

(4) rhizoma sparganic: choose decontamination, be soaked in water, pull out and run through, section is dried;

(5) Rhizoma Curcumae: get crude drug, remove impurity, big or small stepping is cleaned, and slightly soaks, and takes out, runs through, and shave, drying, sieve removes chip;

(6) Radix Rehmanniae: wash earth, remove impurity, cutting;

(7) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;

(8) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck the residual stalk and the base of a fruit;

(9) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

(10) Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

(11) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

(12) Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

(13) Radix Cyathulae: get crude drug, remove impurity, clean, run through, go out removing LU, shave, drying, sieve removes chip;

(14) Fructus Amomi: remove impurity and shell, smash to pieces;

(15) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(16) Fructus Crataegi: choose clean impurity, the sieve enucleation;

(17) Caulis Polygoni Multiflori: clear water is cleaned, and soaks slightly, pulls out, and after running through, cutting is dried;

(18) Semen Ziziphi Spinosae: former medicine is put into the bamboo square-bottomed bamboo basket; Sink in the clear water cylinder, core is kept afloat, shell is heavy water-bed, and Semen Ziziphi Spinosae is pulled out, dries;

(19) Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;

(20) Os Draconis: outwash earth, smash;

(21) Concha Ostreae: clean, dry, pulverize usefulness;

(22) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(23) Radix Aristolochiae: choose decontamination, separately size bar is soaked in water, and pulls out, and profit is even to inside and outside humidity, section, drying;

(24) Pericarpium Citri Reticulatae: brush away earth, choose decontamination, the spray clear water, shredding or section are dried behind the moistening;

(25) Rhizoma Cyperi: choose decontamination, grind into particle, winnow with a dustpan fine, soft fur and smalls;

(26) Pericarpium Citri Reticulatae Viride: choose decontamination, be soaked in water, pull out, run through, section is dried;

(27) Olibanum: choose the sub-impurity of shakeout;

(28) Myrrha: choose decontamination, break into fragment;

(29) Cortex Lycii: choose decontamination and core, slightly wash, dry, cutting;

(30) Herba Artemisiae Annuae: choose decontamination, remove undesirable root, water drenches and makes profit, and cutting is dried;

(31) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;

(32) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days is taken out section, dries;

(33) Radix Astragali: choose decontamination, remove residual root head and hollow the greater, be soaked in water, pull out, run through back section in time, dry;

(34) Flos Lonicerae: sieve removes silt, chooses clean impurity;

(35) Herba Taraxaci: choose decontamination, clean earth, cutting is dried;

(36) Poria cum Radix Pini: get Poria cum Radix Pini's piece or sheet, remove impurity, or get crude drug, remove impurity, clean, run through, be cut into foursquare sheet or piece, dry in the shade;

(2) preparation

(1) preparation of capsule

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini adds decocting twice, each amount of water is advisable to cover powder, intense fire decocts boiling, slow fire boiling 20 minutes, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and be concentrated in 45-50 ℃ of dryings down, it is ground into powder, incapsulates;

(2) preparation of tablet

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, add for the second time 4 times of amounts that water is crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir, precipitation reclaims ethanol and concentrates, and it is dry down at 45-50 ℃, be ground into powder, add the adjuvant compacting in flakes;

(3) preparation of decocting liquid

1. with the Flos Carthami of described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water, add for the first time 2 times of amounts that water is crude drug weight, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;

2. the medicinal residues after will filtering for the first time add 1.5 times of amounts that water is medicinal residues weight, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient;

(4) particulate preparation

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, add for the second time 4 times of amounts that water is crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir, precipitation reclaims ethanol and concentrates, dry down at 45-50 ℃, add adjuvant, become granule;

(5) preparation of unguentum

Flos Carthami with described weight, Semen Persicae, Herba Leonuri, rhizoma sparganic, Rhizoma Curcumae, Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Semen Plantaginis, Radix Notoginseng, Radix Codonopsis, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Amomi, the Radix Paeoniae Alba, Fructus Crataegi, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Cortex Moutan, Os Draconis, Concha Ostreae, Eupolyphaga Seu Steleophaga, Radix Aristolochiae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Olibanum, Myrrha, Cortex Lycii, Herba Artemisiae Annuae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, the Radix Astragali, Flos Lonicerae, Herba Taraxaci, Poria cum Radix Pini decocts with water twice, add for the first time 6 times of amounts that water is crude drug weight, decocted 1.5 hours, 4 times of amounts that add for the second time water crude drug weight, decocted 1 hour, merging the secondary decoction liquor, to be condensed into proportion be 1.35 extractum.