CN103704706B - A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet and preparation method - Google Patents
A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet and preparation method Download PDFInfo
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- CN103704706B CN103704706B CN201310748517.4A CN201310748517A CN103704706B CN 103704706 B CN103704706 B CN 103704706B CN 201310748517 A CN201310748517 A CN 201310748517A CN 103704706 B CN103704706 B CN 103704706B
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- 210000000582 semen Anatomy 0.000 title claims abstract description 46
- 239000007919 dispersible tablet Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 34
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 34
- 239000000284 extract Substances 0.000 claims abstract description 29
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 24
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 17
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 17
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract description 17
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 17
- 229930195725 Mannitol Natural products 0.000 claims abstract description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002472 Starch Polymers 0.000 claims abstract description 17
- 239000004376 Sucralose Substances 0.000 claims abstract description 17
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 17
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 17
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 17
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 17
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 17
- 239000011773 ferrous fumarate Substances 0.000 claims abstract description 17
- 229960000225 ferrous fumarate Drugs 0.000 claims abstract description 17
- 235000002332 ferrous fumarate Nutrition 0.000 claims abstract description 17
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 17
- 239000000594 mannitol Substances 0.000 claims abstract description 17
- 235000010355 mannitol Nutrition 0.000 claims abstract description 17
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 17
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 17
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 17
- 239000000741 silica gel Substances 0.000 claims abstract description 17
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 17
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 17
- 239000011734 sodium Substances 0.000 claims abstract description 17
- 239000008107 starch Substances 0.000 claims abstract description 17
- 235000019698 starch Nutrition 0.000 claims abstract description 17
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 17
- 235000019408 sucralose Nutrition 0.000 claims abstract description 17
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 11
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 11
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 11
- 239000011710 vitamin D Substances 0.000 claims abstract description 11
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 11
- 229940046008 vitamin d Drugs 0.000 claims abstract description 11
- 239000004615 ingredient Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000010298 pulverizing process Methods 0.000 claims description 16
- 239000008187 granular material Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 244000268590 Euryale ferox Species 0.000 claims description 12
- 235000010216 calcium carbonate Nutrition 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 6
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 6
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 6
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 6
- 206010033546 Pallor Diseases 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 208000004880 Polyuria Diseases 0.000 abstract description 3
- 230000037182 bone density Effects 0.000 abstract description 3
- 208000036654 deficiency anemia Diseases 0.000 abstract description 3
- 230000035619 diuresis Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 210000000952 spleen Anatomy 0.000 abstract description 3
- 230000002159 abnormal effect Effects 0.000 abstract description 2
- 235000020995 raw meat Nutrition 0.000 abstract description 2
- 230000035943 smell Effects 0.000 abstract description 2
- 241000600871 Euryale <brittle star> Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126672 traditional medicines Drugs 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprise following parts by weight ingredient: Rhizoma Dioscoreae 200-400g, Semen Euryales 100-200g, Semen Plantaginis 100-200g, Cortex Phellodendri 80-120g, microcrystalline Cellulose 40-60g, Fructus Crataegi extract 0.12-0.32g, calcium carbonate 0.38-0.78g, ferrous fumarate 0.011-0.022g, vitamin C 1-2g, vitamin D 1-2 μ g, mannitol 100-170g, sucralose 10-15g, micropowder silica gel 10-50g, carboxymethyl cellulose 3-5g, carboxymethyl starch sodium 55-80g, magnesium stearate 4-6g.The present invention has spleen invigorating Gu Chong, clearing away heat-damp and promoting diuresis, increase bone density, improves the effects such as nutritional anemia.Be applicable to leucorrhea with yellow discharge, abnormal smells from the patient raw meat dirty etc., for recovering aid.
Description
Technical field
The invention belongs to nutritional health food field, be specially a kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet and preparation method.
Background technology
Leukorrheal diseases and menopathy are all commonly encountered disease, frequently-occurring disease.The speech that " leukorrhagia is all damp syndrome " is "Fu Qingzhu works on obstetric" introductory song, points out again " having this disease because dai channel can not retrain ".Treatment with TCM about has following four methods.Damp eliminating heat clearing away card is shown in that leukorrhagia is yellow turbid smelly dirty, or redly holds concurrently mutually in vain, companion's susceptible to lose temper due to restlessness, and dream of sleeping night is many, fullness and distention in the chest and hypochondrium, and vomiting and nausea is eaten less, bitter taste xerostomia, and stool is not pressed from both sides, tongue BOHUANG or Huang greasy, light red tongue is fat, wiry and frequent pulse.
Western medical treatment many employings composite antibacterial anti-mildew medicine, medication has larger toxic and side effects, and easily repeatedly.Although also have Chinese Traditional Medicines or the formula of a lot for the treatment of gynaecopathia at present, although treatment prescribed preparation is a lot, be all occur with the form of medicine, the dietary product being applicable to long-term edible auxiliary treatment is little.Therefore the dietary product researching and developing a kind of safe adjunct therapy is very with practical value.
Summary of the invention
For above-mentioned situation, technical problem solved by the invention is to provide a kind of spleen invigorating Gu Chong, clearing away heat-damp and promoting diuresis, increase bone density, improves the preparation method of the Rhizoma Dioscoreae Semen Plantaginis dispersible tablet of nutritional anemia, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200-400g, Semen Euryales 100-200g, Semen Plantaginis 100-200g, Cortex Phellodendri 80-120g, microcrystalline Cellulose 40-60g, Fructus Crataegi extract 0.12-0.32g, calcium carbonate 0.38-0.78g, ferrous fumarate 0.011-0.022g, vitamin C 1-2g, vitamin D 1-2 μ g, mannitol 100-170g, sucralose 10-15g, micropowder silica gel 10-50g, carboxymethyl cellulose 3-5g, carboxymethyl starch sodium 55-80g, magnesium stearate 4-6g.
As preferably, described a kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300g, Semen Euryales 150g, Semen Plantaginis 150g, Cortex Phellodendri 100g, microcrystalline Cellulose 50g, Fructus Crataegi extract 0.22g, calcium carbonate 0.58g, ferrous fumarate 0.0165g, vitamin C 1.5g, vitamin D 1.5 μ g, mannitol 135g, sucralose 12.5g, micropowder silica gel 30g, carboxymethyl cellulose 4g, carboxymethyl starch sodium 67.5g, magnesium stearate 5g.
A preparation method for Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam to clean, peeling, stripping and slicing, put into boiling water blanching 3-5min, control water is placed in bruisher and is pounded thick paste, thick paste temperature is controlled as within the scope of 60-65 DEG C, time is that 0.5-1h is dried, Rhizoma Dioscoreae after drying is pulverized, crosses 80-100 mesh sieve, the Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 115-120 DEG C, time is 5-10s, obtains Rhizoma Dioscoreae powder, for subsequent use;
(2) get Semen Euryales, Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8-12 times of water gaging doubly, extract 2-3 time, each 1-3h within the scope of 70-80 DEG C, filter, filtrate merges, concentrated, drying, and get dry extract powder, for subsequent use;
(3) get microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) dried cream powder that Rhizoma Dioscoreae powder obtained for step (1), step (2) obtain is uniformly mixed, in mixture, add vitamin C, vitamin D stirs, blender rotating speed is 10-20r/min, time is 10-20min, add the carboxymethyl cellulose after pulverizing in above-mentioned steps, microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium again, be uniformly mixed 10-15min, obtain mixture, for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 0.5-1.5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Dioscoreae Semen Plantaginis dispersible tablet.
Get fresh Chinese yam in described step (1) to clean, peeling, stripping and slicing, puts into boiling water blanching 5min, and control water is placed in bruisher and is pounded thick paste, thick paste temperature being controlled to be 60 DEG C of condition lower times is that 1h is dried, Rhizoma Dioscoreae after drying is pulverized, crosses 100 mesh sieves, the Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature control is 120 DEG C of condition lower times is 5s, obtains Rhizoma Dioscoreae powder.
Get Semen Euryales in described step (2), Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8 times of water gagings doubly, extract 3 times, each 1.5h 75 DEG C time, filter, filtrate merges, concentrated, and dry, get dry extract powder.
In sum, beneficial effect of the present invention:
The present invention has spleen invigorating Gu Chong, clearing away heat-damp and promoting diuresis, increase bone density, improves the effects such as nutritional anemia.Be applicable to leucorrhea with yellow discharge, abnormal smells from the patient raw meat dirty etc., for recovering aid.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 200g, Semen Euryales 100g, Semen Plantaginis 100g, Cortex Phellodendri 80g, microcrystalline Cellulose 40g, Fructus Crataegi extract 0.12g, calcium carbonate 0.38g, ferrous fumarate 0.011g, vitamin C 1g, vitamin D 1 μ g, mannitol 100g, sucralose 10g, micropowder silica gel 10g, carboxymethyl cellulose 3g, carboxymethyl starch sodium 55g, magnesium stearate 4g.
A preparation method for Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam to clean, peeling, stripping and slicing, put into boiling water blanching 3-5min, control water is placed in bruisher and is pounded thick paste, thick paste temperature is controlled as within the scope of 60-65 DEG C, time is that 0.5-1h is dried, Rhizoma Dioscoreae after drying is pulverized, crosses 80-100 mesh sieve, the Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 115-120 DEG C, time is 5-10s, obtains Rhizoma Dioscoreae powder, for subsequent use;
(2) get Semen Euryales, Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8-12 times of water gaging doubly, extract 2-3 time, each 1-3h within the scope of 70-80 DEG C, filter, filtrate merges, concentrated, drying, and get dry extract powder, for subsequent use;
(3) get microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) dried cream powder that Rhizoma Dioscoreae powder obtained for step (1), step (2) obtain is uniformly mixed, in mixture, add vitamin C, vitamin D stirs, blender rotating speed is 10-20r/min, time is 10-20min, add the carboxymethyl cellulose after pulverizing in above-mentioned steps, microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium again, be uniformly mixed 10-15min, obtain mixture, for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 0.5-1.5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Dioscoreae Semen Plantaginis dispersible tablet.
Embodiment 2
A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 300g, Semen Euryales 150g, Semen Plantaginis 150g, Cortex Phellodendri 100g, microcrystalline Cellulose 50g, Fructus Crataegi extract 0.22g, calcium carbonate 0.58g, ferrous fumarate 0.0165g, vitamin C 1.5g, vitamin D 1.5 μ g, mannitol 135g, sucralose 12.5g, micropowder silica gel 30g, carboxymethyl cellulose 4g, carboxymethyl starch sodium 67.5g, magnesium stearate 5g.
A preparation method for Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam to clean, peeling, stripping and slicing, put into boiling water blanching 3-5min, control water is placed in bruisher and is pounded thick paste, thick paste temperature is controlled as within the scope of 60-65 DEG C, time is that 0.5-1h is dried, Rhizoma Dioscoreae after drying is pulverized, crosses 80-100 mesh sieve, the Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 115-120 DEG C, time is 5-10s, obtains Rhizoma Dioscoreae powder, for subsequent use;
(2) get Semen Euryales, Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8-12 times of water gaging doubly, extract 2-3 time, each 1-3h within the scope of 70-80 DEG C, filter, filtrate merges, concentrated, drying, and get dry extract powder, for subsequent use;
(3) get microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) dried cream powder that Rhizoma Dioscoreae powder obtained for step (1), step (2) obtain is uniformly mixed, in mixture, add vitamin C, vitamin D stirs, blender rotating speed is 10-20r/min, time is 10-20min, add the carboxymethyl cellulose after pulverizing in above-mentioned steps, microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium again, be uniformly mixed 10-15min, obtain mixture, for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 0.5-1.5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Dioscoreae Semen Plantaginis dispersible tablet.
Embodiment 3
A kind of Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises following parts by weight ingredient: Rhizoma Dioscoreae 400g, Semen Euryales 200g, Semen Plantaginis 200g, Cortex Phellodendri 120g, microcrystalline Cellulose 60g, Fructus Crataegi extract 0.32g, calcium carbonate 0.78g, ferrous fumarate 0.022g, vitamin C 2g, vitamin D 2 μ g, mannitol 170g, sucralose 15g, micropowder silica gel 50g, carboxymethyl cellulose 5g, carboxymethyl starch sodium 80g, magnesium stearate 6g.
A preparation method for Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, comprises the following steps:
(1) get fresh Chinese yam to clean, peeling, stripping and slicing, put into boiling water blanching 3-5min, control water is placed in bruisher and is pounded thick paste, thick paste temperature is controlled as within the scope of 60-65 DEG C, time is that 0.5-1h is dried, Rhizoma Dioscoreae after drying is pulverized, crosses 80-100 mesh sieve, the Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature controls as within the scope of 115-120 DEG C, time is 5-10s, obtains Rhizoma Dioscoreae powder, for subsequent use;
(2) get Semen Euryales, Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8-12 times of water gaging doubly, extract 2-3 time, each 1-3h within the scope of 70-80 DEG C, filter, filtrate merges, concentrated, drying, and get dry extract powder, for subsequent use;
(3) get microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) dried cream powder that Rhizoma Dioscoreae powder obtained for step (1), step (2) obtain is uniformly mixed, in mixture, add vitamin C, vitamin D stirs, blender rotating speed is 10-20r/min, time is 10-20min, add the carboxymethyl cellulose after pulverizing in above-mentioned steps, microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium again, be uniformly mixed 10-15min, obtain mixture, for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 0.5-1.5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Dioscoreae Semen Plantaginis dispersible tablet.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (1)
1. a Rhizoma Dioscoreae Semen Plantaginis dispersible tablet, is characterized in that: be made up of following parts by weight ingredient: Rhizoma Dioscoreae 300g, Semen Euryales 150g, Semen Plantaginis 150g, Cortex Phellodendri 100g, microcrystalline Cellulose 50g, Fructus Crataegi extract 0.22g, calcium carbonate 0.58g, ferrous fumarate 0.0165g, vitamin C 1.5g, vitamin D 1.5 μ g, mannitol 135g, sucralose 12.5g, micropowder silica gel 30g, carboxymethyl cellulose 4g, carboxymethyl starch sodium 67.5g, magnesium stearate 5g; Its preparation method is:
(1) get fresh Chinese yam to clean, peeling, stripping and slicing, puts into boiling water blanching 5min, control water is placed in bruisher and is pounded thick paste, thick paste temperature being controlled to be 60 DEG C of condition lower times is that 1h is dried, and is pulverized by the Rhizoma Dioscoreae after drying, crosses 100 mesh sieves, Rhizoma Dioscoreae after pulverizing is carried out high temperature instantaneous sterilization, temperature control is 120 DEG C of condition lower times is 5s, obtains Rhizoma Dioscoreae powder, for subsequent use;
(2) get Semen Euryales, Semen Plantaginis, Cortex Phellodendri clean, add raw materials quality 8 times of water gagings doubly, extract 3 times, each 1.5h 75 DEG C time, filter, filtrate merges, concentrated, and dry, get dry extract powder, for subsequent use;
(3) get microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl cellulose, carboxymethyl starch sodium, magnesium stearate pulverize respectively, cross 100-150 mesh sieve, for subsequent use;
(4) dried cream powder that Rhizoma Dioscoreae powder obtained for step (1), step (2) obtain is uniformly mixed, in mixture, add vitamin C, vitamin D stirs, blender rotating speed is 10-20r/min, time is 10-20min, add the carboxymethyl cellulose after pulverizing in above-mentioned steps, microcrystalline Cellulose, Fructus Crataegi extract, calcium carbonate, ferrous fumarate, mannitol, sucralose, micropowder silica gel, carboxymethyl starch sodium again, be uniformly mixed 10-15min, obtain mixture, for subsequent use;
(5) mixture that step (4) is obtained is carried out making granule, granule is dried 0.5-1.5h within the scope of 30-45 DEG C, cross 20-40 mesh sieve;
(6) granule after sieving is added the magnesium stearate mixing machine after pulverizing to mix, rotating speed is 10-15r/min, and the time is 6-8min, then carries out tabletting, obtains Rhizoma Dioscoreae Semen Plantaginis dispersible tablet.
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| CN101474333A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Yam dispensing granule as well as preparation method and quality control method thereof |
| CN102743549A (en) * | 2012-07-11 | 2012-10-24 | 李承平 | Spleen and kidney tonifying tablet |
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| CN102743549A (en) * | 2012-07-11 | 2012-10-24 | 李承平 | Spleen and kidney tonifying tablet |
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