CN103704705A - 一种苎麻根续断分散片及制备方法 - Google Patents
一种苎麻根续断分散片及制备方法 Download PDFInfo
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- CN103704705A CN103704705A CN201310748512.1A CN201310748512A CN103704705A CN 103704705 A CN103704705 A CN 103704705A CN 201310748512 A CN201310748512 A CN 201310748512A CN 103704705 A CN103704705 A CN 103704705A
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Abstract
本发明公开了一种苎麻根续断分散片,包括以下重量份成分:山药400-600份、苎麻根100-300份、续断100-300份、杜仲100-300份、微晶纤维素40-60份、云芝提取物0.12-0.32份、珍珠粉0.35-0.75份、乳酸亚铁0.12-0.32份、维生素C1-2份、维生素E0.003-0.007份、甘露醇120-150份、三氯蔗糖10-15份、微粉硅胶20-40份、羧甲基纤维素3-5份、羧甲基淀粉钠55-80份、硬脂酸镁4-6份、纯化水适量。本发明具有固肾益气安胎、增强免疫力、增加骨质密度、改善营养性贫血等功效,适用于习惯性流产,用于辅助康复。
Description
技术领域
本发明属于营养保健食品领域,具体为一种苎麻根续断分散片及制备方法。
背景技术
习惯性流产为自然流产连续3次以上者,每次流产往往发生在同一妊娠月份、纯化水适量。中医称为“滑胎”。习惯性流产的原因大多为孕妇黄体功能不全、甲状腺功能低下、先天性子宫畸形、子宫发育异常、***、子宫肌瘤、染色体异常、自身免疫等。习惯性流产习惯性晚期流产常为子宫颈内口松弛所致。多由于***或扩张宫颈所引起的子宫颈口损伤,少数可能属于先天性发育异常。此类病人在中期妊娠之后,由于羊水增长,胎儿长大,宫腔内压力增高,胎囊可自宫颈内口突出,当宫腔内压力增高至一定程度,就会破膜而流产,故流产前常常没有自觉症状。目前虽然也有很多习惯性流产的中成药物或配方,虽然治疗成方制剂很多,但是都是以药的形式出现,适合长期食用辅助治疗的食疗产品却很少。因此研究开发一种安全辅助治疗的食疗产品非常有实用价值。
发明内容
针对上述情况,本发明所解决的技术问题是提供一种固肾益气安胎、增强免疫力、增加骨质密度、改善营养性贫血的苎麻根续断分散片的制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:
一种苎麻根续断分散片,包括以下重量份成分:山药400-600份、苎麻根100-300份、续断100-300份、杜仲100-300份、微晶纤维素40-60份、云芝提取物0.12-0.32份、珍珠粉0.35-0.75份、乳酸亚铁0.12-0.32份、维生素C 1-2份、维生素E 0.003-0.007份、甘露醇120-150份、三氯蔗糖10-15份、微粉硅胶20-40份、羧甲基纤维素3-5份、羧甲基淀粉钠55-80份、硬脂酸镁4-6份、纯化水适量。
作为优选,所述的一种苎麻根续断分散片,包括以下重量份成分:山药500份、苎麻根200份、续断200份、杜仲200份、微晶纤维素50份、云芝提取物0.22份、珍珠粉0.55份、乳酸亚铁0.22份、维生素C 1.5份、维生素E 0.005份、甘露醇135份、三氯蔗糖12.5份、微粉硅胶30份、羧甲基纤维素3-5份、羧甲基淀粉钠67.5份、硬脂酸镁5份、纯化水适量。
一种苎麻根续断分散片的制备方法,包括以下步骤:
(1)取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡2-3h,将浸泡后的山药进行45-65℃范围内低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6-8,然后加温,待温度上升至50-80℃范围内时,加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.1-0.15,搅拌均匀,保温20-30min后继续加温,当温度达100℃时保温1-1.2h,浓缩成山药浆液,备用;
(2)取原料苎麻根、续断、杜仲用40-50℃范围内温开水中浸泡并清洗,再将预处理后的原料在75-85℃范围内烘培2-5h,将烘培后的原料进行粉碎经100-120目过筛,所得粉碎的原料在密封箱中加水浸泡1-2天,浸泡后收集上清液,用60-85%乙醇加热回流3-4h,过滤得滤液,所得滤液在60-80℃范围内浓缩到相对密度为1.1-1.15的膏状物,回收乙醇,得到稠膏,备用;
(3)取微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基纤维素、羧甲基淀粉钠、硬脂酸镁分别粉碎,过100-150目筛,备用;
(4)将步骤(1)制得的山药浆液、步骤(2)制得的稠膏搅拌混合,向混合物中加入维生素C、维生素E搅拌均匀,搅拌机转速为10-20r/min,时间为10-20min,再加入上述步骤中粉碎后的羧甲基纤维素、微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基淀粉钠,搅拌混合10-15min,得混合物,备用;
(5)将步骤(4)制得的混合物进行制成颗粒,将颗粒在30-45℃范围内烘干1-5h,过20-40目筛;
(6)将过筛后的颗粒加入粉碎后的硬脂酸镁用混匀机混匀,转速为10-15r/min,时间为6-8min,再进行压片,即得苎麻根续断分散片。
所述的步骤(1)中取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡3h,将浸泡后的山药进行55℃条件下低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6,然后加温,待温度上升至70℃时加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.15,搅拌均匀,保温30min后继续加温,当温度达100℃时保温1.2h,浓缩成山药浆液。
所述的步骤(2)中取原料苎麻根、续断、杜仲用50℃条件下温开水中浸泡并清洗,再将预处理后的原料在75℃条件下烘培2.5h,将烘培后的原料进行粉碎经100目过筛,所得粉碎的原料在密封箱中加水浸泡2天,浸泡后收集上清液,用85%乙醇加热回流3h,过滤得滤液,所得滤液在60℃时浓缩到相对密度为1.15的膏状物,回收乙醇,得到稠膏。
综上所述,本发明有益效果:
本发明具有固肾益气安胎、增强免疫力、增加骨质密度、改善营养性贫血等功效,适用于习惯性流产,用于辅助康复。
具体实施方式
下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种苎麻根续断分散片,包括以下重量份成分:山药400份、苎麻根100份、续断100份、杜仲100份、微晶纤维素40份、云芝提取物0.12份、珍珠粉0.35份、乳酸亚铁0.12份、维生素C 1份、维生素E 0.003份、甘露醇120份、三氯蔗糖10份、微粉硅胶20份、羧甲基纤维素3份、羧甲基淀粉钠55份、硬脂酸镁4份、纯化水适量。
一种苎麻根续断分散片的制备方法,包括以下步骤:
(1)取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡2-3h,将浸泡后的山药进行45-65℃范围内低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6-8,然后加温,待温度上升至50-80℃范围内时,加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.1-0.15,搅拌均匀,保温20-30min后继续加温,当温度达100℃时保温1-1.2h,浓缩成山药浆液,备用;
(2)取原料苎麻根、续断、杜仲用40-50℃范围内温开水中浸泡并清洗,再将预处理后的原料在75-85℃范围内烘培2-5h,将烘培后的原料进行粉碎经100-120目过筛,所得粉碎的原料在密封箱中加水浸泡1-2天,浸泡后收集上清液,用60-85%乙醇加热回流3-4h,过滤得滤液,所得滤液在60-80℃范围内浓缩到相对密度为1.1-1.15的膏状物,回收乙醇,得到稠膏,备用;
(3)取微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基纤维素、羧甲基淀粉钠、硬脂酸镁分别粉碎,过100-150目筛,备用;
(4)将步骤(1)制得的山药浆液、步骤(2)制得的稠膏搅拌混合,向混合物中加入维生素C、维生素E搅拌均匀,搅拌机转速为10-20r/min,时间为10-20min,再加入上述步骤中粉碎后的羧甲基纤维素、微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基淀粉钠,搅拌混合10-15min,得混合物,备用;
(5)将步骤(4)制得的混合物进行制成颗粒,将颗粒在30-45℃范围内烘干1-5h,过20-40目筛;
(6)将过筛后的颗粒加入粉碎后的硬脂酸镁用混匀机混匀,转速为10-15r/min,时间为6-8min,再进行压片,即得苎麻根续断分散片。
实施例2
一种苎麻根续断分散片,包括以下重量份成分:山药500份、苎麻根200份、续断200份、杜仲200份、微晶纤维素50份、云芝提取物0.22份、珍珠粉0.55份、乳酸亚铁0.22份、维生素C 1.5份、维生素E 0.005份、甘露醇135份、三氯蔗糖12.5份、微粉硅胶30份、羧甲基纤维素4份、羧甲基淀粉钠67.5份、硬脂酸镁5份、纯化水适量。
一种苎麻根续断分散片的制备方法,包括以下步骤:
(1)取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡2-3h,将浸泡后的山药进行45-65℃范围内低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6-8,然后加温,待温度上升至50-80℃范围内时,加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.1-0.15,搅拌均匀,保温20-30min后继续加温,当温度达100℃时保温1-1.2h,浓缩成山药浆液,备用;
(2)取原料苎麻根、续断、杜仲用40-50℃范围内温开水中浸泡并清洗,再将预处理后的原料在75-85℃范围内烘培2-5h,将烘培后的原料进行粉碎经100-120目过筛,所得粉碎的原料在密封箱中加水浸泡1-2天,浸泡后收集上清液,用60-85%乙醇加热回流3-4h,过滤得滤液,所得滤液在60-80℃范围内浓缩到相对密度为1.1-1.15的膏状物,回收乙醇,得到稠膏,备用;
(3)取微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基纤维素、羧甲基淀粉钠、硬脂酸镁分别粉碎,过100-150目筛,备用;
(4)将步骤(1)制得的山药浆液、步骤(2)制得的稠膏搅拌混合,向混合物中加入维生素C、维生素E搅拌均匀,搅拌机转速为10-20r/min,时间为10-20min,再加入上述步骤中粉碎后的羧甲基纤维素、微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基淀粉钠,搅拌混合10-15min,得混合物,备用;
(5)将步骤(4)制得的混合物进行制成颗粒,将颗粒在30-45℃范围内烘干1-5h,过20-40目筛;
(6)将过筛后的颗粒加入粉碎后的硬脂酸镁用混匀机混匀,转速为10-15r/min,时间为6-8min,再进行压片,即得苎麻根续断分散片。
实施例3
一种苎麻根续断分散片,包括以下重量份成分:山药600份、苎麻根300份、续断300份、杜仲300份、微晶纤维素60份、云芝提取物0.32份、珍珠粉0.75份、乳酸亚铁0.32份、维生素C 2份、维生素E 0.007份、甘露醇150份、三氯蔗糖15份、微粉硅胶40份、羧甲基纤维素5份、羧甲基淀粉钠80份、硬脂酸镁6份、纯化水适量。
一种苎麻根续断分散片的制备方法,包括以下步骤:
(1)取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡2-3h,将浸泡后的山药进行45-65℃范围内低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6-8,然后加温,待温度上升至50-80℃范围内时,加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.1-0.15,搅拌均匀,保温20-30min后继续加温,当温度达100℃时保温1-1.2h,浓缩成山药浆液,备用;
(2)取原料苎麻根、续断、杜仲用40-50℃范围内温开水中浸泡并清洗,再将预处理后的原料在75-85℃范围内烘培2-5h,将烘培后的原料进行粉碎经100-120目过筛,所得粉碎的原料在密封箱中加水浸泡1-2天,浸泡后收集上清液,用60-85%乙醇加热回流3-4h,过滤得滤液,所得滤液在60-80℃范围内浓缩到相对密度为1.1-1.15的膏状物,回收乙醇,得到稠膏,备用;
(3)取微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基纤维素、羧甲基淀粉钠、硬脂酸镁分别粉碎,过100-150目筛,备用;
(4)将步骤(1)制得的山药浆液、步骤(2)制得的稠膏搅拌混合,向混合物中加入维生素C、维生素E搅拌均匀,搅拌机转速为10-20r/min,时间为10-20min,再加入上述步骤中粉碎后的羧甲基纤维素、微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基淀粉钠,搅拌混合10-15min,得混合物,备用;
(5)将步骤(4)制得的混合物进行制成颗粒,将颗粒在30-45℃范围内烘干1-5h,过20-40目筛;
(6)将过筛后的颗粒加入粉碎后的硬脂酸镁用混匀机混匀,转速为10-15r/min,时间为6-8min,再进行压片,即得苎麻根续断分散片。
对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。
此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。
Claims (5)
1.一种苎麻根续断分散片,其特征在于:包括以下重量份成分:山药400-600份、苎麻根100-300份、续断100-300份、杜仲100-300份、微晶纤维素40-60份、云芝提取物0.12-0.32份、珍珠粉0.35-0.75份、乳酸亚铁0.12-0.32份、维生素C 1-2份、维生素E 0.003-0.007份、甘露醇120-150份、三氯蔗糖10-15份、微粉硅胶20-40份、羧甲基纤维素3-5份、羧甲基淀粉钠55-80份、硬脂酸镁4-6份、纯化水适量。
2. 根据权利要求1所述的一种苎麻根续断分散片,其特征在于:包括以下重量份成分:山药500份、苎麻根200份、续断200份、杜仲200份、微晶纤维素50份、云芝提取物0.22份、珍珠粉0.55份、乳酸亚铁0.22份、维生素C 1.5份、维生素E 0.005份、甘露醇135份、三氯蔗糖12.5份、微粉硅胶30份、羧甲基纤维素3-5份、羧甲基淀粉钠67.5份、硬脂酸镁5份、纯化水适量。
3. 一种苎麻根续断分散片的制备方法,其特征在于:包括以下步骤:
(1)取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡2-3h,将浸泡后的山药进行45-65℃范围内低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6-8,然后加温,待温度上升至50-80℃范围内时,加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.1-0.15,搅拌均匀,保温20-30min后继续加温,当温度达100℃时保温1-1.2h,浓缩成山药浆液,备用;
(2)取原料苎麻根、续断、杜仲用40-50℃范围内温开水中浸泡并清洗,再将预处理后的原料在75-85℃范围内烘培2-5h,将烘培后的原料进行粉碎经100-120目过筛,所得粉碎的原料在密封箱中加水浸泡1-2天,浸泡后收集上清液,用60-85%乙醇加热回流3-4h,过滤得滤液,所得滤液在60-80℃范围内浓缩到相对密度为1.1-1.15的膏状物,回收乙醇,得到稠膏,备用;
(3)取微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基纤维素、羧甲基淀粉钠、硬脂酸镁分别粉碎,过100-150目筛,备用;
(4)将步骤(1)制得的山药浆液、步骤(2)制得的稠膏搅拌混合,向混合物中加入维生素C、维生素E搅拌均匀,搅拌机转速为10-20r/min,时间为10-20min,再加入上述步骤中粉碎后的羧甲基纤维素、微晶纤维素、云芝提取物、珍珠粉、乳酸亚铁、甘露醇、三氯蔗糖、微粉硅胶、羧甲基淀粉钠,搅拌混合10-15min,得混合物,备用;
(5)将步骤(4)制得的混合物进行制成颗粒,将颗粒在30-45℃范围内烘干1-5h,过20-40目筛;
(6)将过筛后的颗粒加入粉碎后的硬脂酸镁用混匀机混匀,转速为10-15r/min,时间为6-8min,再进行压片,即得苎麻根续断分散片。
4. 根据权利要求3所述的一种苎麻根续断分散片的制备方法,其特征在于:所述的步骤(1)中取新鲜山药去杂质去皮,用水洗净,再用0.1%维生素C水溶液浸泡3h,将浸泡后的山药进行55℃条件下低温干燥,将干燥后的山药切成山药片,将山药片置炒锅中文火加热,炒至表面焦黄,取出放晾,将炒制后的山药片加入纯化水进行打浆,山药片与纯化水的比例为1∶6,然后加温,待温度上升至70℃时加入α-淀粉酶,山药浆液与α-淀粉酶的比例为100∶0.15,搅拌均匀,保温30min后继续加温,当温度达100℃时保温1.2h,浓缩成山药浆液。
5. 根据权利要求3所述的一种苎麻根续断分散片的制备方法,其特征在于:所述的步骤(2)中取原料苎麻根、续断、杜仲用50℃条件下温开水中浸泡并清洗,再将预处理后的原料在75℃条件下烘培2.5h,将烘培后的原料进行粉碎经100目过筛,所得粉碎的原料在密封箱中加水浸泡2天,浸泡后收集上清液,用85%乙醇加热回流3h,过滤得滤液,所得滤液在60℃时浓缩到相对密度为1.15的膏状物,回收乙醇,得到稠膏。
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