CN103623273B - A kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis - Google Patents
A kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, be prepared from by the medical material of following weight proportion: Cortex Trematis Cannabinae Radicis 16 parts, 14 parts, hilllock Eurya plant leaf, just 14 parts, bamboo, wide leaf Herba Urticae Cannabinae 12 parts, Radix Syringae velutinae 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, fall hair grass 10 parts, large Herba Hyperici Japonici 14 parts, Rhizoma Polygonati punctati 14 parts, Folium Bauhiniae pernervosae 10 parts, Folium et Cacumen Acanthopanacis Trifoliati 12 parts, Coriaria sinica 10 parts, Swertia kauitchensis Franch 16 parts, Auricled Hedyotis Herb 8 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 parts, Semen Stizolobii Cochinchinensis 14 parts, Cortex berberidis dasystachyae 18 parts, turn celery 12 parts, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 parts, Herba Zephyranthis Candidae 10 parts, gal mutter fragrant 8 parts.Clinical trial certificate, the present invention can safe and effective treatment Henoch Schonlein purpura nephritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis.
Background technology
Henoch Schonlein purpura nephritis means the renal damage that anaphylactoid purpura causes with the systemic disease that necrotizing small vessel inflammation is main pathological change.Clinical manifestation apart from skin purpura, arthralgia, suffer from abdominal pain, have blood in stool outside, renal involvement main manifestations is that hematuria and albuminuria, part patient with severe symptoms can cause impaired renal function.Renal involvement is multiple be born in skin purpura after a couple of days in several weeks.Its cause of disease can be the allergy caused by infection such as antibacterial, virus and parasite, or is the allergy such as some drugs, food, or causes for plant pollen, insect bite etc.Erythra is the starting and main clinical manifestation of primary disease, and erythra occurs in distal limbs, buttocks and hypogastric region, many symmetry distribution, and a little higher than skin surface can have gargalesthesia.Be everlasting in 2 weeks interval time from purpura to kidney damage.
The effective medicine of generally recognized as safe is still lacked at present for Henoch Schonlein purpura nephritis.
Involved by Chinese medicine of the present invention, the present Research of medical material is as follows:
The root bark Herb that Cortex Trematis Cannabinae Radicis [source] is Ulmaceae Cortex Trematis Cannabinae Radicis.Summer, autumn gather, using fresh herb or dry.[function cures mainly] diuretic; Removing toxic substances; Blood circulation promoting and blood stasis dispelling.Main watery diarrhea; Influenza; Venom; Injured bone.
The leaf that hilllock Eurya plant leaf [source] is plant of theaceae hilllock Eurya plant.The whole year all can gather, using fresh herb or dry.[function cures mainly] expelling phlegm for arresting cough; Removing toxic substances and promoting subsidence of swelling.Main pulmonary tuberculosis cough; Innominate toxic swelling; Impetigo; Traumatic injury; Fracture.
Firm bamboo [source] grass family firm bamboo Phyllostachys bambusoides Sieb. et Zucc., with root, fruit medicine.[function cures mainly] Eradicates wind heat, the meridian dredging, hemostasis.Cure mainly cough due to pathogenic wind-heat, asthma, extremity insensitive impediment, bones and muscles pain, metrorrhagia.
Wide leaf Herba Urticae Cannabinae [source] Urticaceae Urtica plant wide leaf Herba Urticae Cannabinae Urtica laetevirens Maxim., is used as medicine with herb, root and seed.Herb is on the ground extracted, decontamination, cutting, using fresh herb or dry when summer, stem and leaf was luxuriant.Root and seed were gathered in the autumn and winter.[function cures mainly] expelling wind for relieving convulsion, help digestion relieving constipation.For rheumatic arthritis, puerperal convulsion, infantile convulsion, poliomyelitis sequela, hypertension, dyspepsia, constipation; External controls urticaria from the beginning of, venom.
The leaf that Radix Syringae velutinae [source] is Oleaceae plants Northeast Syringa pubescens.Summer, autumn gather, and dry or using fresh herb.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing jaundice eliminating.Main acute icterohepatitis.
Ipomoea hungaiensis Lingelsh. Et Borza. [source] Convolvulaceae morning glory Ipomoea hungaiensis Lingelsh. Et Borza. Ipomoea hungaiensis Lingelsh. etBorza, is used as medicine with tuber.Autumn excavates, and cleans, and section, dries.[function cures mainly] spleen invigorating removing food stagnancy, dampness removing.For infantile malnutrition, agalactosis, hepatitis, leucorrhea; Burn and scald is controlled in external.
Fall hair grass [source] Celastraceae tripterygium plant Tripterygium hypoglaucum Tripterygium hypoglaucum (Levl.) Hutch., with root bark or all herbal medicine.The whole year can adopt, and cleans, dries.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove blood stasis, reunion of fractured tendons and bones.For rheumatic arthritis, traumatic injury, hemiplegia, lumbar muscle strain; Fracture is controlled in external, traumatic hemorrhage.
The herb that large Herba Hyperici Japonici [source] is Ofthe Primulaceae Arisaema balansae Engl. grass or root.The 4-8 month gathers, using fresh herb or dry.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing heat from blood and promoting blood circulation; Removing toxic substances and promoting subsidence of swelling.Main jaundice; Dysentery; Conjunctival congestion; Spit blood; Stranguria with blood; Leucorrhea; Metrorrhagia; Dysmenorrhea; Amenorrhea; Laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Erysipelas; Scrofula; Traumatic injury; Snake bite and insect sting.
The brightly yellowish smart Polygonatum punctatum Royle exKunth of Rhizoma Polygonati punctati [source] Liliaceae HUANGJING ZANYU CAPSULE point, with root stock or all herbal medicine.Autumn and winter excavate, and clean, dry.[function cures mainly] removing toxic substances and promoting subsidence of swelling, hemostasis.Traumatic hemorrhage is controlled in external, carbuncle furunculosis, scabies, tinea capitis.
Folium Bauhiniae pernervosae [source] is pulse family bauhinia many arteries and veins Bauhinia purpurea Bauhinia pernervosa L.Chen, is used as medicine with root and leaf.Autumn uproots; Picking leaves in summer, cleans and dries.[function cures mainly] tonifying the kidney to consolidate the essence, cough-relieving, hemostasis.Root: seminal emission, the enuresis, cough, metrorrhagia.Leaf: proctoptosis, uterine prolapse.
The browse that Folium et Cacumen Acanthopanacis Trifoliati [source] is the white Jin of Araliaceae.The whole year can adopt.[function cures mainly] controls carbuncle, treats skin ulcer, mange, wound, stomachache.
Coriaria sinica [source] Coriariaceae Coriaria plant Coriaria sinica Coriaria sinica Maxim., is used as medicine with root, leaf.Root is excavated winter, scrapes off crust, dries; Leaf is adopted summer, dries.[function cures mainly] expelling wind and removing dampness, analgesia, parasite killing.Root: for tuberculous lymphadenitis, traumatic injury, lyssodexis, rheumatic arthritis; Leaf: burn and scald is controlled in external, tinea capitis, eczema, sore swollen toxin.
The herb that Swertia kauitchensis Franch [source] is gentianaceae plant Swertia kauitchensis Franch.Summer, autumn gather, and clean, dry.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing.Main fever of children; Bitter taste hectic fever; Damp and hot yellow cellulitis; Laryngopharynx swelling and pain; Dyspepsia; Gastritis; Aphtha; Toothache; Acute catarrhal conjunctivitis; Venom.
The herb of Auricled Hedyotis Herb [source] Rubiaceae plants of Hedyotis Auricled Hedyotis Herb Hedyotis auricularia L..The whole year can adopt, and cleans, using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For cold, fever, cough due to lung-heat, laryngalgia, acute conjunctivitis, enteritis, dysentery; Venom is controlled in external, traumatic injury, carbuncle pyogenic infections from tumour or sore, mastitis, eczema.
The alabastrum of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) [source] thymelaeceae Flos Wikstroemiae Dolichanthae platymiscium Wikstroemia chamaedaphne (Bge.) Meisn. Wikstroemia chamaedaphne Meisn., leaf also can be used as medicine.To pick flowers early autumn flower bud and leaf, dry in the shade or dry.[function cures mainly] removing water retention by purgation, relieving constipation.For edema distension, phlegm retention is gathered, cough with dyspnea dyspnea with fullness of the chest, acute and chronic infectious hepatitis, schizophrenia, epilepsy.
The seed that Semen Stizolobii Cochinchinensis [source] is leguminous plant dragon's paw Semen stizolobii capitati or leaf.Autumn gathers, and lays seed, dries.[function cures mainly] warming middle-JIAO QI invigorating.Control ache of the spinal column.
Cortex berberidis dasystachyae [source] is the peel of stem of the straight fringe Radix Berberidis Amurensis of Berberidaceae plant.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.Control hematodiarrhoea to have blood in stool, jaundice due to damp-heat, lower limb swell and ache, hectic fever night sweat, wind-fire ophthalmalgia, erosion of the oral mucosa, tongue boil, mastitis and carbuncle skin ulcer from the beginning of.
Turn celery [source] for samphire and turn the root of celery.Excavate before not blooming between summer, autumn, clean, dry.[function cures mainly] is delivered and is dispeled the wind; Warming spleen and stomach for dispelling cold; Regulating QI to relieve pain.Main exterior syndrome due to wind-cold; Pathogenic wind-warm arthralgia pain; Gastral cavity abdomen; Pain in chest and hypochondrium; Traumatic injury.
The rhizome that Stegnogramma cyrtomioides (C. Chr.) Ching． [source] is Thelypteridaceae plant Stegnogramma cyrtomioides (C. Chr.) Ching．.[function cures mainly] suppressing the hyperactive liver and subsiding YANG.Main dizzy; Vexed insomnia; Night sweat.
Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) [source] for Acanthaceae wrap up in hedge firewood platymiscium wrap up in hedge firewood Gendarussa vulgaris Nees [Justicia gendarussa L.F.] be used as medicine with Herb.The whole year can adopt, and cleans and dries or using fresh herb.[function cures mainly] reunion of fractured tendons and bones, reducing swelling and alleviating pain.For fracture, bruise, rheumatic arthritis.
The herb that Herba Zephyranthis Candidae [source] is amrallid Herba Alii fistulosi lotus all can adopt the heart whole year, cleans, mostly is using fresh herb.[function cures mainly] suppressing the hyperactive liver to relieve the wind syndrome.Main infantile convulsion; Epilepsy; Tetanus.
Gal is muttered the timber containing volume resin that perfume (or spice) [source] is Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum or the nearly root of Lignum Aquilariae Resinatum.Choose Lignum Aquilariae Resinatum medium oil (resin) foot, body constitution is heavy and timber stick that property is glutinous, its oil-containing of pruning is few and part that color is light.[function cures mainly] regulates the flow of vital energy, and pain relieving is sensible.Control and uncomfortable in chestly not relax, stagnation of QI pain, wind-phlegm is inaccessible.Merit victory Lignum Aquilariae Resinatum.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing Henoch Schonlein purpura nephritis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, it is characterized in that, be prepared from by the medical material of following weight proportion: Cortex Trematis Cannabinae Radicis 16 parts, 14 parts, hilllock Eurya plant leaf, just 14 parts, bamboo, wide leaf Herba Urticae Cannabinae 12 parts, Radix Syringae velutinae 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, fall hair grass 10 parts, large Herba Hyperici Japonici 14 parts, Rhizoma Polygonati punctati 14 parts, Folium Bauhiniae pernervosae 10 parts, Folium et Cacumen Acanthopanacis Trifoliati 12 parts, Coriaria sinica 10 parts, Swertia kauitchensis Franch 16 parts, Auricled Hedyotis Herb 8 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 parts, Semen Stizolobii Cochinchinensis 14 parts, Cortex berberidis dasystachyae 18 parts, turn celery 12 parts, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 parts, Herba Zephyranthis Candidae 10 parts, gal mutter fragrant 8 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects the out-patient of 149 routine Henoch Schonlein purpura nephritises-2012 years in November, 2010 altogether between JIUYUE, age 21-45 year, course of disease 1-5.Be divided at random: treatment group 107 example, blank group 42 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
2, test method
The capsule that the oral the present invention of 2.1 treatment group obtains according to specific embodiment 1, sooner or later respectively once.30 days courses for the treatment of.
2.2 blank group oral placebo capsules, sooner or later respectively once.30 days courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, test chamber inspection is normal, observes having no recurrence in three months more afterwards.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) | Untoward reaction example |
| Treatment group | 107 | 33（30.8%） | 58（54.2%) | 16（15%) | 85% | 0 |
| Blank group | 42 | 1（2.4%） | 5（11.9%） | 36（85.7%） | 14.3% | 0 |
Visible, the medicine that the present invention obtains can safe and effective treatment Henoch Schonlein purpura nephritis.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
specific embodiment 1
Take: Cortex Trematis Cannabinae Radicis 16 grams, 14 grams, hilllock Eurya plant leaf, just 14 grams, bamboo, wide leaf Herba Urticae Cannabinae 12 grams, Radix Syringae velutinae 15 grams, Ipomoea hungaiensis Lingelsh. Et Borza. 15 grams, fall hair grass 10 grams, large Herba Hyperici Japonici 14 grams, Rhizoma Polygonati punctati 14 grams, Folium Bauhiniae pernervosae 10 grams, Folium et Cacumen Acanthopanacis Trifoliati 12 grams, Coriaria sinica 10 grams, Swertia kauitchensis Franch 16 grams, Auricled Hedyotis Herb 8 grams, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 grams, Semen Stizolobii Cochinchinensis 14 grams, Cortex berberidis dasystachyae 18 grams, turn celery 12 grams, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 grams, Herba Zephyranthis Candidae 10 grams, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, the capsule of adult normal's 1 day consumption must be met.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
specific embodiment 2
Take: Cortex Trematis Cannabinae Radicis 16 grams, 14 grams, hilllock Eurya plant leaf, just 14 grams, bamboo, wide leaf Herba Urticae Cannabinae 12 grams, Radix Syringae velutinae 15 grams, Ipomoea hungaiensis Lingelsh. Et Borza. 15 grams, fall hair grass 10 grams, large Herba Hyperici Japonici 14 grams, Rhizoma Polygonati punctati 14 grams, Folium Bauhiniae pernervosae 10 grams, Folium et Cacumen Acanthopanacis Trifoliati 12 grams, Coriaria sinica 10 grams, Swertia kauitchensis Franch 16 grams, Auricled Hedyotis Herb 8 grams, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 grams, Semen Stizolobii Cochinchinensis 14 grams, Cortex berberidis dasystachyae 18 grams, turn celery 12 grams, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 grams, Herba Zephyranthis Candidae 10 grams, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, pulverize, the powder of adult normal's 1 day consumption must be met.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
specific embodiment 3
Take: Cortex Trematis Cannabinae Radicis 16 grams, 14 grams, hilllock Eurya plant leaf, just 14 grams, bamboo, wide leaf Herba Urticae Cannabinae 12 grams, Radix Syringae velutinae 15 grams, Ipomoea hungaiensis Lingelsh. Et Borza. 15 grams, fall hair grass 10 grams, large Herba Hyperici Japonici 14 grams, Rhizoma Polygonati punctati 14 grams, Folium Bauhiniae pernervosae 10 grams, Folium et Cacumen Acanthopanacis Trifoliati 12 grams, Coriaria sinica 10 grams, Swertia kauitchensis Franch 16 grams, Auricled Hedyotis Herb 8 grams, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 grams, Semen Stizolobii Cochinchinensis 14 grams, Cortex berberidis dasystachyae 18 grams, turn celery 12 grams, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 grams, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 grams, Herba Zephyranthis Candidae 10 grams, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, then add appropriate dextrin and correctives, granulate according to this area common process, packaging, can obtain the granule meeting adult normal's 1 day consumption.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. treat the Chinese medicine of Henoch Schonlein purpura nephritis for one kind, it is characterized in that, be prepared from by the medical material of following weight proportion: Cortex Trematis Cannabinae Radicis 16 parts, 14 parts, hilllock Eurya plant leaf, just 14 parts, bamboo, wide leaf Herba Urticae Cannabinae 12 parts, Radix Syringae velutinae 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, fall hair grass 10 parts, large Herba Hyperici Japonici 14 parts, Rhizoma Polygonati punctati 14 parts, Folium Bauhiniae pernervosae 10 parts, Folium et Cacumen Acanthopanacis Trifoliati 12 parts, Coriaria sinica 10 parts, Swertia kauitchensis Franch 16 parts, Auricled Hedyotis Herb 8 parts, Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) 8 parts, Semen Stizolobii Cochinchinensis 14 parts, Cortex berberidis dasystachyae 18 parts, turn celery 12 parts, Stegnogramma cyrtomioides (C. Chr.) Ching． 10 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 8 parts, Herba Zephyranthis Candidae 10 parts, gal mutter fragrant 8 parts.
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