CN103598579A - 含有大豆异黄酮的保健食品 - Google Patents
含有大豆异黄酮的保健食品 Download PDFInfo
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- CN103598579A CN103598579A CN201310552672.9A CN201310552672A CN103598579A CN 103598579 A CN103598579 A CN 103598579A CN 201310552672 A CN201310552672 A CN 201310552672A CN 103598579 A CN103598579 A CN 103598579A
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- 235000013305 food Nutrition 0.000 title abstract 4
- 235000003687 soy isoflavones Nutrition 0.000 title abstract 3
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 4
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 8
- 150000002515 isoflavone derivatives Chemical class 0.000 claims description 8
- 235000008696 isoflavones Nutrition 0.000 claims description 8
- 235000013402 health food Nutrition 0.000 claims description 5
- 210000000988 bone and bone Anatomy 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 abstract 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229940016667 resveratrol Drugs 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 description 17
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 229910052791 calcium Inorganic materials 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 206010017076 Fracture Diseases 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 230000037182 bone density Effects 0.000 description 5
- 210000000689 upper leg Anatomy 0.000 description 5
- 208000010392 Bone Fractures Diseases 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004904 shortening Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 201000000916 idiopathic juvenile osteoporosis Diseases 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 1
- 241001456553 Chanodichthys dabryi Species 0.000 description 1
- 206010010214 Compression fracture Diseases 0.000 description 1
- 206010016997 Forearm fracture Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 description 1
- 208000002103 Shoulder Fractures Diseases 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000037180 bone health Effects 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
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- 239000007884 disintegrant Substances 0.000 description 1
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- 210000000245 forearm Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- 210000002345 respiratory system Anatomy 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
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- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种含有大豆异黄酮的保健食品，主要是由白藜芦醇、大豆异黄酮为主要原料制备而得，该中药可增加中老年人骨密度。
Description
技术领域
本发明属于生物医药领域，具体涉及一种含有大豆异黄酮的保健食品。
背景技术
骨质疏松症是一种常见病和多发病，它严重地威胁着中老年人，尤其是绝经后女性的身体健康。由骨质疏松引起的骨折等并发症，给患者造成了极大的痛苦，还给社会和家庭带来了沉重的经济和生活负担。据报导，50岁以后发生骨质疏松的女性在10年内出现髋部、脊柱、前臂或肱骨近端骨折的可能性高达45%；大于65岁老人在无意识跌倒时，有87%会造成骨质疏松性骨折。我国老年人的绝对数量占世界第一位，并随着生活水平的提高和人口寿命的增长，老龄人口正在急剧增多，因此，骨质疏松症的诊断及其防治就显得十分重要。
骨质疏松症可分为三大类，一类为原发性骨质疏松症，是一种随着年龄的增长必然发生的生理性退行性病变。第二类为继发性骨质疏松症，它是由其它疾病或药物等一些因素所诱发的骨质疏松症。第三类为特发性骨质疏松症，多见于8～14岁的青少年或成人，多半有家庭遗传病史，女性多于男性。妊娠妇女及哺乳期妇女所发生的骨质疏松也可列入特发性骨质疏松，以便引起人们的重视。
骨质疏松症的主要临床表现和体征为：疼痛、身高缩短、驼背、脆性骨折及呼吸***障碍等。
1）疼痛
疼痛是骨质疏松症的常见症状，其原因主要是由于骨转换高，骨吸收增加。在骨吸收过程中，骨小梁的破坏、消失，骨膜下皮质骨的破坏等均会引起全身性骨痛，其中以腰背痛最为多见。另一个引起疼痛的重要原因是骨折。
2）身高缩短、驼背
在无声无息中身高缩短或者驼背，是继腰背痛之后出现的重要临床体征之一，有时身高缩短5-20厘米不等。
3）脆性骨折
在骨质疏松症中，骨骼骨折阈值明显地降低，从而受轻微的外力就易发生骨折。
4）呼吸***障碍
严重骨质疏松症所致胸、腰椎压缩性骨折，常常导致脊柱后凸、胸廓畸形，胸腔容量明显下降，有时可引起多个脏器的功能变化，其中呼吸***的表现尤为突出。
防治骨质疏松症的最终目的是减少骨折的发生。临床上采用延缓和减少骨量丢失，争取重获骨量，增加骨骼强度而达到此目的。骨质疏松症的治疗措施分为基础措施和药物治疗两个方面。基础措施中骨健康补充剂主要是钙剂和维生素D；药物治疗主要包括抗骨吸收药物、促骨形成药物和其他药物。
发明内容
本发明的目的在于提供一种含有大豆异黄酮的保健食品。
为达到上述目的，本发明采用下列重量比的组分：白藜芦醇5份、大豆异黄酮10份。
上述发明中还可以加入的食用或药用辅料包括：稀释剂、助悬剂、抗氧化剂、乳化剂、崩解剂、黏合剂和防腐剂。
具体实施方式
实施例1：含有大豆异黄酮的保健食品，其原料及重量份为：白藜芦醇5份、大豆异黄酮10份，制成胶囊剂、片剂、颗粒剂、口服液、散剂、袋泡茶等。
实施例2：功效性研究
发明人对本发明内容中提到的具体实施方式制得的产品，与钙剂进行服用效果比较研究，以下列举其中的一组实验数据。
将30只雄性SD大鼠按体重均衡原则分为3组：低钙对照组、碳酸钙对照组及本发明组，各组大鼠自由进食相应的专配饲料。大鼠连续喂养13周，末次给药后24小时，处死，分离左侧股骨，去净皮肉，测定左侧股骨的骨密度。
本发明对大鼠骨密度的影响
| 组别 | 动物数（只） | 股骨中点骨密度(g/cm2) |
| 低钙对照组 | 10 | 0.102±0.009 |
| 碳酸钙对照组 | 10 | 0.109±0.010* |
| 本发明组 | 10 | 0.114±0.013* |
与低钙对照组比较，*P<0.05
结果显示，骨密度实验中，与低钙对照组比较，本发明组大鼠股骨质量、骨钙含量及股骨中点骨密度均显著增加，表明本发明对骨质疏松化有抑制作用。
Claims (1)
1.含有大豆异黄酮的保健食品，其特征在于，包括如下重量比的组分：白藜芦醇5份、大豆异黄酮10份。
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310552672.9A CN103598579A (zh) | 2013-11-08 | 2013-11-08 | 含有大豆异黄酮的保健食品 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310552672.9A CN103598579A (zh) | 2013-11-08 | 2013-11-08 | 含有大豆异黄酮的保健食品 |
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| CN103598579A true CN103598579A (zh) | 2014-02-26 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1629281A (zh) * | 2004-09-01 | 2005-06-22 | 山西林丰实业有限公司 | 一种生态型白酒 |
| CN1634300A (zh) * | 2004-11-05 | 2005-07-06 | 广州国桥医药研究有限公司 | 一种口服抗衰老保健品 |
| CN1680240A (zh) * | 2004-04-09 | 2005-10-12 | 汪云 | 含白藜芦醇和大豆异黄酮的组合物及其制备方法与应用 |
| US20090239943A1 (en) * | 2008-03-19 | 2009-09-24 | Sarkar Fazlul H | Nutraceutical composition and methods for its use |
| CN102038126A (zh) * | 2010-11-09 | 2011-05-04 | 万光瑞 | 调血脂综合拮抗动脉粥样硬化的保健食品及其制备方法 |
-
2013
- 2013-11-08 CN CN201310552672.9A patent/CN103598579A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1680240A (zh) * | 2004-04-09 | 2005-10-12 | 汪云 | 含白藜芦醇和大豆异黄酮的组合物及其制备方法与应用 |
| CN1629281A (zh) * | 2004-09-01 | 2005-06-22 | 山西林丰实业有限公司 | 一种生态型白酒 |
| CN1634300A (zh) * | 2004-11-05 | 2005-07-06 | 广州国桥医药研究有限公司 | 一种口服抗衰老保健品 |
| US20090239943A1 (en) * | 2008-03-19 | 2009-09-24 | Sarkar Fazlul H | Nutraceutical composition and methods for its use |
| CN102038126A (zh) * | 2010-11-09 | 2011-05-04 | 万光瑞 | 调血脂综合拮抗动脉粥样硬化的保健食品及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 刘兆平等: "白藜芦醇的生物学作用", 《国外医学.卫生学分册》, vol. 29, no. 03, 31 December 2002 (2002-12-31), pages 146 - 148 * |
| 毕海丹: "白藜芦醇保健医药专利研究进展", 《安徽农业科学》, vol. 39, no. 02, 31 December 2011 (2011-12-31) * |
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Application publication date: 20140226 |