CN103565916A - Traditional Chinese medicine composition for treating keratosis type tinea of feet and hands as well as preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating keratosis type tinea of feet and hands as well as preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating keratosis type tinea of feet and hands. The traditional Chinese medicine composition is a medicament prepared from the following raw materials in parts by weight: 170-190 parts of salicylic acid, 110-130 parts of benzoic acid, 350-450 parts of boric acid, 150-250 parts of radix sophorae flavescentis powder and 90-110 parts of talcum powder. The invention further discloses a preparation method of the traditional Chinese medicine composition for treating keratosis type tinea of feet and hands, wherein the preparation method comprises the following steps of: crushing radix sophorae flavescentis and sieving by using a 40-80-mesh sieve to obtain radix sophorae flavescentis powder; crushing salicylic acid, benzoic acid, boric acid and talcum powder and sieving by using the 40-80-mesh sieve to obtain first mixed powder; mixing the radix sophorae flavescentis powder with the first mixed powder to obtain second mixed powder which is the traditional Chinese medicine composition for treating keratosis type tinea of feet and hands. The traditional Chinese medicine composition disclosed by the invention is simple in components, short in course of treatment and convenient to use and can take effect quickly. The preparation method disclosed by the invention reduces labor power investment, shortens production period and improves production efficiency.
Description
Technical field
The embodiment of the present invention relates to a kind of keratinization type tinea manus and pedis Chinese medicine composition and preparation method thereof for the treatment of
Background technology
Keratinization type tinea manus and pedis, is also beriberi, is to be caused by fungal infection, is infectious, and mostly occurs referring to, between toe and on palm, sole, sometimes also can spread on the back of the hand, instep; Referring to, between toe seam and hands, sole etc. locate the place of hyperhidrosis humidity, sickness rate is higher; From the beginning of time mostly be the blister of needle point size, blister constantly bears, a burst of is scratched where it itches, and can have transparent transudate in a small amount after scratching, a couple of days rear peeling, within after decortication several days, get blister again again afterwards.Keratinization type tinea manus and pedis is many to be formed by the development of vesicle squama type, and patient has medical history for many years, has often involved both hands, both feet, skin lesion is without obvious vesicle or annular desquamation, trick facies palmaris diffuse thickening, dermatoglyph is deepened, pachylosis, dry and have a desquamation, easily chap winter, and breach has hemorrhage deeply, hurt like hell, affect activity, give orthobiosis of patient and brought a lot of puzzlements and inconvenience.From the traditional Chinese medical science, tinea manus and pedis belongs to the category of Surgery of Chinese Medicine dermatosis class " tinea ", " smelly Cipangopaludina chinensis ", " river snail-like blebs ", " foot bifurcation is rotten to the corn " etc. in TCM Document, and what refer to is all primary disease.Primary disease is that brothers' erosion is flowed juice and had special odor, generally first have an itch then wet rotten, or plantar flexed part is itched wet all right.Primary disease is apt to occur in adult, and summer and autumn attach most importance to, and the winter in spring is light.This disease etiology and pathogenesis is to be formed through damp invasion of lower energizer by taste two, or occupies wetland for a long time, in water, works, and water slurry dipping, infects due to noxious dampness.At present the medicine for the treatment of keratinization type tinea manus and pedis is many, mostly is ointment, and not only curative effect owes desirable, and side effect greatly, easily recurrence.
In powder preparation is produced, especially the powder preparation being mixed by the different powder body of multiple relative density, due to it, there is the features such as specific surface area is large, poor fluidity, in its preparation process, easily there is the problems such as mixing is inhomogeneous, layering, caking, bridge formation, and then affect product quality, be also difficult to realize automated production.
Summary of the invention
The object of the invention is to solve the defect of above-mentioned prior art, provide that a kind of composition is simple, instant effect, short treating period, treatment keratinization type tinea manus and pedis Chinese medicine composition easy to use.
Another object of the present invention is to provide the preparation method of this treatment keratinization type tinea manus and pedis Chinese medicine composition.
For solving above-mentioned technical problem, the present invention by the following technical solutions:
A keratinization type tinea manus and pedis Chinese medicine composition, it is the medicament of being made by the raw material of following weight proportion: 170～190 parts of salicylic acid, 110～130 parts, benzoic acid, 350～450 parts of boric acid, 150～250 parts of Radix Sophorae Flavescentis powder, 90～110 parts of Pulvis Talci.Salicylic acid, for the anticorrosion class medicine of sterilization, has cutin dissolution, can grow by Antifungi; Benzoic acid has antibacterial actions, can grow by Antifungi; Boric acid is weak antiseptic, and fungus is had to inhibitory action; Radix Sophorae Flavescentis powder has heat clearing and damp drying, antipruritic, the effect of dispeling the wind, and these four kinds of medicine combineds effect have antifungal, antipruritic, arresting sweating effect.The present invention is for solving powder preparation (powder preparation especially being mixed by the different powder body of multiple relative density) aborning, because of features such as specific surface area is large, poor fluidities, and the problems such as the mixing causing is inhomogeneous, layering, caking, bridge formation, in salicylic acid, benzoic acid, boric acid, Radix Sophorae Flavescentis powder, added Pulvis Talci, it is inertia powder body, the effect not only with damp eliminating sore, also there is hydrophobicity, agglomeration resistance and fluidizer effect, also filler, dispersant have been served as simultaneously, greatly improve the mobility of powder body, also prevented powder agglomeration.
In above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, salicylic acid: 175～185 parts, benzoic acid: 105～125 parts, boric acid: 380～420 parts, Radix Sophorae Flavescentis powder: 180～220 parts, Pulvis Talci: 95～105 parts.
In above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, best proportioning is: salicylic acid: 180 parts, and benzoic acid: 120 parts, boric acid: 400 parts, Radix Sophorae Flavescentis powder: 200 parts, Pulvis Talci: 100 parts.
In above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, described medicament is powder, during use, be dissolved in boiling water, the dissolubility that can increase medicine increases the drug effect of medicine, and can make medicinal liquid permeate fully, enduringly and contact with affected part, exempt other mode dosage forms and because not directly acting on affected part, caused the untoward reaction such as side effect, the greasy feeling of also having avoided ointment to bring.
In above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition; preferably; on powder surface, directly add anti-caking agent; make powder surface form the hydrophobic protecting film of one deck; can prevent powder product and extraneous moisture exchange; also can hinder the generation of crystal bridging in the recrystallization process that crystalline state powder surface occurs, finally prevent product caking.
The invention provides a kind of preparation method for the treatment of keratinization type tinea manus and pedis Chinese medicine composition, concrete steps are:
Radix Sophorae Flavescentis was pulverized separately to 40 to 80 mesh sieves, obtained Radix Sophorae Flavescentis powder,
Salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 40 to 80 mesh sieves, obtain the first mixed powder,
Described Radix Sophorae Flavescentis powder is mixed 10 to 30 minutes with described the first mixed powder, obtain the second mixed powder, be treatment keratinization type tinea manus and pedis Chinese medicine composition.
In the preparation method of above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, the conveying of described Radix Sophorae Flavescentis powder, the first mixed powder adopts the dustless closed conveying of vacuum.
In the preparation method of above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, Radix Sophorae Flavescentis was pulverized separately to 60 mesh sieves.
In the preparation method of above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 60 mesh sieves.
In the preparation method of above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition, preferably, when described Radix Sophorae Flavescentis powder is mixed with described the first mixed powder, first Radix Sophorae Flavescentis powder is placed in to bottom, then the first mixed powder is placed in to Radix Sophorae Flavescentis powder top, then mix.
The ratio of above-mentioned whole powder is the ratio of above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition Raw.
The method is pulverized separately Radix Sophorae Flavescentis, is that it compares hard with salicylic acid, benzoic acid, boric acid, and contains a large amount of fibers, is difficult for pulverizing and sieving, therefore take independent pulverizing because Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Take into account drug effect of the present invention and crush efficiency, and Sophora flavescens feature (fibre-bearing amount is large), the medicated powder fineness of pulverizing is larger, the easier stripping of its contained effective ingredient, but crush efficiency is lower, and production process medicated powder mobility is poorer.When controlling medicated powder fineness after Sophora flavescens is pulverized at 40 orders (granularity 425 μ m) during to 80 orders (granularity 180 μ m), the fine stripping of its ingredient energy, when best medicated powder fineness is controlled at 60 orders (granularity 250 μ m), drug effect and production efficiency are best, and after also unlikely Radix Sophorae Flavescentis powder and salicylic acid, benzoic acid, boric acid, Pulvis Talci always mix, medicated powder mobility is too poor.
For ease of effective dissolving of salicylic acid, benzoic acid, boric acid, also, for guaranteeing to pulverize the mobility of rear its medicated powder, when pulverizing and sieving, controlling its medicated powder fineness is 40 to 80 orders, and best medicated powder fineness is controlled at 60 orders.Meanwhile, add Pulvis Talci to carry out together co-grinding, can improve the mobility of medicated powder after pulverizing, be beneficial to the dustless smooth and easy conveying of vacuum tightness of medicated powder, also can improve the homogeneity of mixing when it always mixes with Radix Sophorae Flavescentis powder simultaneously.
Radix Sophorae Flavescentis powder is mixed with the first mixed powder, the object of mixing is that each component in powder is uniformly dispersed, color and luster is consistent, to guarantee that dosage is accurate, safe and effective for medication, the mixing of drug powder is subject to powder shape, density, granule size and distribution, skin effect, the impact of device type and operating condition etc., during mixing, the more irregular person of powder of regular shape is easy to mix, out-of-shape person is general, and its mobility is poor, even the complex-shaped powder of minority can link together, tiny powder hinders powder because surperficial power can make powder gather to be disperseed in blender, these power comprise weak Van der Waals force, electrostatic charge power and on the indirect contact of powder the surface tension etc. of adsorptive liquid thin film, in these three kinds of power, the most important thing is electrostatic charge power, it hinders the main cause of mixing often in blender, in order to prevent that segregation phenomenon from appearring in powder, need to when reaching maximum mixed effect, stop operating or alternately each component be added to blender: due to Radix Sophorae Flavescentis powder, salicylic acid, benzoic acid, boric acid, talcous density is all different, when total mixing, if the time is too short, cannot mix homogeneous, if overlong time, the medicated powder that mixes homogeneous is secondary clearing and cannot mixing again, and then affects product quality and drug effect.In five kinds of materials, Radix Sophorae Flavescentis powder density is minimum, for improving the homogeneity of its mixing, when mixing, first Radix Sophorae Flavescentis powder is delivered to the bottom of mixing apparatus by vacuum tightness clean conveyance system, then the medicated powder after other are pulverized and sieved is delivered to mixing apparatus.Incorporation time is 10 to 30 minutes, best results when incorporation time is 20 minutes.
Effect of the present invention and advantage are as follows: Chinese medicine composition of the present invention adopts powder form, have specific surface area greatly, easily disperse, prove effective that stability fast, medicine is high, preparation technology simple, dosage is easy to the feature of controlling, and given full play to the effective ingredient of medicine; Chinese medicine composition composition of the present invention is simple, instant effect, and short treating period (course for the treatment of on the three), (directly soaking) easy to use, has heat clearing and damp drying, the effect of parasite killing arresting sweating; Method of the present invention has reduced the input of manpower, financial resources, material resources simply greatly because of preparation technology, reduce production cost, shortened the production cycle, improve production environment (medicated powder is carried and adopted the dustless closed conveying of vacuum), and improved production efficiency (productivity per worker improves more than 200% relatively).
The specific embodiment
Embodiment mono-: by following proportioning take raw material (kilogram): salicylic acid 180, benzoic acid 120, boric acid 400, Radix Sophorae Flavescentis powder 200, Pulvis Talci 100.
Above-mentioned raw materials is dried, then Radix Sophorae Flavescentis was pulverized separately to 60 mesh sieves, obtain Radix Sophorae Flavescentis powder; Salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 60 mesh sieves, obtain the first mixed powder; First Radix Sophorae Flavescentis powder is placed in to blender bottom, then the first mixed powder is placed in to Radix Sophorae Flavescentis powder top, then mix 20 minutes, obtain the second mixed powder, be treatment keratinization type tinea manus and pedis Chinese medicine composition composition powders.During use, get 40 grams, above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition medicated powder and add 1000 milliliters of boiling water, stir, dissolve, put temperature, soak while hot affected part 20～30 minutes, 1 time on the one, continuous three days is a course for the treatment of, and curative effect is in Table one.The present embodiment is optimum proportion of materials of the present invention, and raw material pulverizing fineness is moderate, and medicated powder incorporation time is moderate, last mixed powder stable homogeneous, products obtained therefrom instant effect, curative effect is good, short treating period, easy to use, and preparation technology is simple, production efficiency is high, with short production cycle, production cost is low.
Embodiment bis-: by following proportioning take raw material (kilogram): salicylic acid 170, benzoic acid 110, boric acid 350, Radix Sophorae Flavescentis powder 150, Pulvis Talci 90.
Above-mentioned raw materials is dried, then Radix Sophorae Flavescentis was pulverized separately to 40 mesh sieves, obtain Radix Sophorae Flavescentis powder; Salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 40 mesh sieves, obtain the first mixed powder; First Radix Sophorae Flavescentis powder is placed in to blender bottom, then the first mixed powder is placed in to Radix Sophorae Flavescentis powder top, then mix 10 minutes, obtain the second mixed powder, be treatment keratinization type tinea manus and pedis Chinese medicine composition composition powders.During use, get 40 grams, above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition medicated powder and add 1000 milliliters of boiling water, stir, dissolve, put temperature, soak while hot affected part 20～30 minutes, 1 time on the one, continuous three days is a course for the treatment of, and curative effect is in Table one.The present embodiment proportioning raw materials within the scope of the present invention, raw material pulverizing fineness is within the scope of medicated powder fineness of the present invention, medicated powder incorporation time is within the scope of incorporation time of the present invention, but compared with embodiment mono-medicated powder is slightly thick, incorporation time is slightly short, there is production efficiency high, medicated powder good fluidity, is convenient to the features such as packing.
Embodiment tri-: by following proportioning take raw material (kilogram): salicylic acid 190, benzoic acid 130, boric acid 450, Radix Sophorae Flavescentis powder 250, Pulvis Talci 110.
Above-mentioned raw materials is dried, then Radix Sophorae Flavescentis was pulverized separately to 80 mesh sieves, obtain Radix Sophorae Flavescentis powder; Salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 80 mesh sieves, obtain the first mixed powder; First Radix Sophorae Flavescentis powder is placed in to blender bottom, then the first mixed powder is placed in to Radix Sophorae Flavescentis powder top, then mix 30 minutes, obtain the second mixed powder, be treatment keratinization type tinea manus and pedis Chinese medicine composition composition powders.During use, get 40 grams, above-mentioned treatment keratinization type tinea manus and pedis Chinese medicine composition medicated powder and add 1000 milliliters of boiling water, stir, dissolve, put temperature, soak while hot affected part 20～30 minutes, 1 time on the one, continuous three days is a course for the treatment of, and curative effect is in Table one.The present embodiment proportioning raw materials within the scope of the present invention, raw material pulverizing fineness is within the scope of medicated powder fineness of the present invention, medicated powder incorporation time is within the scope of incorporation time of the present invention, though compared with embodiment mono-medicated powder is slightly thin, mobility is slightly poor, mix that difficulty is slightly large, incorporation time is slightly long, and production efficiency is low, but the easier stripping of its ingredient, clinical efficacy is better.
Table one: curative effect
In embodiment mono-to three, treatment group adopts Chinese medicine composition of the present invention, and matched group adopts the tinea manus and pedis medicine of selling on the market.Curative effect determinate standard:
Recovery from illness: symptom, sign all disappear, negative fungal examination;
Effective: symptom, sign disappear more than 80%, fungus microscope examination can be negative;
Take a turn for the better: symptom, sign disappear more than 30%, fungus microscope examination can be positive;
Invalid: symptom, sign are without disappearing, and fungus microscope examination is positive.
If the Chinese medicine composition making can not disposablely be finished, should seal, protection against the tide, and note the impact on powder quality such as humiture, microorganism.
When factory mass is produced, need to carry out packing to the Chinese medicine composition making, for the bridge formation problem that prevents from occurring in packaging process, preferably use the material cycling device of patent No. 201210266767.X to have enough to meet the need, and preferably to use the patent No. be that 201220372085.2 the device that material is built bridge in hopper that prevents carries out packing, to realize automated production.
" embodiment " that spoken of in this manual, " another embodiment ", " embodiment ", etc., refer to specific features, structure or the feature in conjunction with this embodiment, described and be included at least one embodiment that the application's generality describes.In description, a plurality of local appearance statement of the same race is not necessarily to refer to same embodiment.Furthermore, while describing a specific features, structure or feature in conjunction with arbitrary embodiment, what advocate is in conjunction with other embodiment, to realize this feature, structure or feature also to fall within the scope of the invention.
Although with reference to a plurality of explanatory embodiment of the present invention, invention has been described here, but, should be appreciated that, those skilled in the art can design a lot of other modification and embodiments, and these are revised and within embodiment will drop on the disclosed principle scope and spirit of the application.More particularly, in the scope of and claim open in the application, can carry out multiple modification and improvement to the building block of subject combination layout and/or layout.Except modification that building block and/or layout are carried out with improving, to those skilled in the art, other purposes will be also obvious.
Claims (10)
1. a treatment keratinization type tinea manus and pedis Chinese medicine composition, is characterized in that, it is the medicament of being made by the raw material of following weight proportion:
Salicylic acid: 170～190 parts,
Benzoic acid: 110～130 parts,
Boric acid: 350～450 parts,
Radix Sophorae Flavescentis powder: 150～250 parts,
Pulvis Talci: 90～110 parts.
2. treat according to claim 1 keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, it is the medicament of being made by the raw material of following weight proportion:
Salicylic acid: 175～185 parts,
Benzoic acid: 105～125 parts,
Boric acid: 380～420 parts,
Radix Sophorae Flavescentis powder: 180～220 parts,
Pulvis Talci: 95～105 parts.
3. treat according to claim 1 keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, it is the medicament of being made by the raw material of following weight proportion:
Salicylic acid: 180 parts,
Benzoic acid: 120 parts,
Boric acid: 400 parts,
Radix Sophorae Flavescentis powder: 200 parts,
Pulvis Talci: 100 parts.
4. according to described in claim 1,2 or 3, treat keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, described medicament is powder.
5. treat according to claim 4 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that,
Radix Sophorae Flavescentis was pulverized separately to 40 to 80 mesh sieves, obtained Radix Sophorae Flavescentis powder,
Salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 40 to 80 mesh sieves, obtain the first mixed powder,
Described Radix Sophorae Flavescentis powder is mixed 10 to 30 minutes with described the first mixed powder, obtains the second mixed powder,
Be treatment keratinization type tinea manus and pedis Chinese medicine composition,
The ratio of above-mentioned whole powder is the ratio described in claim 1,2 or 3.
6. treat according to claim 5 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, the conveying of described Radix Sophorae Flavescentis powder, the first mixed powder adopts the dustless closed conveying of vacuum.
7. treat according to claim 6 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, Radix Sophorae Flavescentis was pulverized separately to 60 mesh sieves.
8. treat according to claim 6 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, salicylic acid, benzoic acid, boric acid, Pulvis Talci are carried out to co-grinding and cross 60 mesh sieves.
9. treat according to claim 6 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, when described Radix Sophorae Flavescentis powder is mixed with described the first mixed powder, first Radix Sophorae Flavescentis powder is placed in to bottom, again the first mixed powder is placed in to Radix Sophorae Flavescentis powder top, then mixes.
10. treat according to claim 6 the preparation method of keratinization type tinea manus and pedis Chinese medicine composition, it is characterized in that, described Radix Sophorae Flavescentis powder is mixed 20 minutes with described the first mixed powder.
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| CN109125571A (en) * | 2018-11-09 | 2019-01-04 | 陈文玉 | A kind of Chinese medicine and preparation method thereof for treating onychomycosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104013878A (en) * | 2014-06-26 | 2014-09-03 | 湖南天龙制药有限公司 | Foot-bathing medicinal vinegar for quickly treating dermatophytosis and preparation method thereof |
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| CN107595932A (en) * | 2017-10-19 | 2018-01-19 | 何远峰 | Cuticula is loosened cream and its preparation method and application |
| CN107929624A (en) * | 2017-11-16 | 2018-04-20 | 王衡山 | A kind of ointment for treating tinea pedis and preparation method thereof |
| CN109125571A (en) * | 2018-11-09 | 2019-01-04 | 陈文玉 | A kind of Chinese medicine and preparation method thereof for treating onychomycosis |
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