CN107595932A - Cuticula is loosened cream and its preparation method and application - Google Patents
Cuticula is loosened cream and its preparation method and application Download PDFInfo
- Publication number
- CN107595932A CN107595932A CN201710976032.9A CN201710976032A CN107595932A CN 107595932 A CN107595932 A CN 107595932A CN 201710976032 A CN201710976032 A CN 201710976032A CN 107595932 A CN107595932 A CN 107595932A
- Authority
- CN
- China
- Prior art keywords
- parts
- cuticula
- cream
- loosened
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
Abstract
Loosened cream and its preparation method and application the present invention relates to a kind of cuticula, cuticula cream of loosening includes the raw materials of following parts by weight：1 part~10 parts of 30 parts~50 parts of lanolin, 40 parts~60 parts of vaseline, 1 part~10 parts of salicylic acid, 3 parts~15 parts of benzoic acid, 5 parts~20 parts of boric acid and kuh-seng.The cuticula of the present invention lanolin added in cream of loosening can strengthen Medicated Permeation, coordinate vaseline composition sustained release base, rational formula salicylic acid, benzoic acid, boric acid, kuh-seng, pass through the sustained release osmotic of 24 hours cuticula debonding agents, the keratoderma at dispenser position of thoroughly loosening.Can efficiently and rapidly be loosened keratoderma, and loosened from the topical application of drug to cuticula only needs 48 hours completely, solve the problems, such as current various cuticula loosen paste formulation speed of loosening it is too slow.The cuticula newly born can also be affected, and become weak and loose.The cuticula cream of loosening of the present invention has good clinical effectiveness and commercial promise.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of cuticula is loosened cream and its preparation method and application.
Background technology
Tinea of feet and hands is due to have infected skin disease caused by shallow fungi.Body depth can be invaded with deep fungal
Portion's tissue is different, and shallow fungi can only infect epidermis.Most Symptoms of tinea of feet and hands are all shallow fungal attacks
During corium, body produces immunoprotection and produced.Although clinical manifestation is various, parting is also had nothing in common with each other, and the cause of disease is very
Clearly, it is exactly the infection of shallow fungi.The key that fungi is treatment is eliminated as far as possible, and this is common recognition, but wants face
Face many difficulties.
First, localized infection is in epidermis, mainly cuticula.The blood circulation at this position is poor, can be reached after oral
Medicine to infection site is seldom, and effect is limited.Further, since fungi is also eucaryotic organism (bacterium is not), so energy
Enough medicines to be worked to fungi can also often work to human tissue cell.It thus be accordingly used in oral medication fungal infection
Side effects of pharmaceutical drugs are all bigger.Individual drugs (such as Itraconazole) are very big so that being needed during medication to hepatic effects
Liver function monitoring is done, and adds liver-protecting medicine.Although side effect is more, these oral medicines toward contact costly.Based on this
Kind situation, topical administration is to treat the Main Means of tinea of feet and hands at present.
Second, due to the compact texture of horny layer of epidermis, the externally applied drug that horny layer of epidermis reaches pathogenic position can be permeated
Thing is equally also seldom, and therapeutic effect is also limited.For hyperkeratotic pattern, due to the cuticula that it is thickened, outside coating is treated, then
Effect is worse.
3rd, mycelia and fungal spore are the brood bodies of fungi.The medicine that fungal spore can really be killed cans be counted on one's fingers.Mound
Rash, blister, erosion etc. cause horny layer of epidermis damaged, although can now kill the fungi of breakage in breakage dispenser,
It is to also have mycelia to exist under the complete horny layer of epidermis in its periphery, thus even such case, surface medication effect are all
Limited.
Based on the above situation, with horny layer of epidermis debonding agent, loosen and infected the keratoderma of shallow fungi, make angle
Matter layer comes off, while physical removal fungi is just into a relatively good scheme.But current various cuticula are loosened, cream is matched somebody with somebody
The shortcomings that Fang Youyi is individual common：Speed of loosening is too slow.Often to pass through a couple of days after dispenser, old cuticula could be peeled off.And
Inside the time in the past few days, newly longer skin is infected by original fungi again.
In a word, the present situation for the treatment of tinea of feet and hands is at present：Scheme is more, weak curative effect, easily recurrence.
The content of the invention
It is an object of the present invention to propose that a kind of cuticula is loosened cream.
The cuticula of the present invention is loosened cream, includes the raw material of following parts by weight：30 parts~50 parts of lanolin, vaseline 40
1 part~10 parts of part~60 parts, 1 part~10 parts of salicylic acid, 3 parts~15 parts of benzoic acid, 5 parts~20 parts of boric acid and kuh-seng.
The cuticula of the present invention lanolin added in cream of loosening can strengthen Medicated Permeation, coordinate vaseline composition sustained release
Base, rational formula salicylic acid, benzoic acid, boric acid, kuh-seng are thoroughly loose by the sustained release osmotic of 24 hours cuticula debonding agents
Solve the keratoderma at dispenser position.Can efficiently and rapidly be loosened keratoderma, be loosened from the topical application of drug to cuticula completely only
Need 48 hours, solve the problems, such as current various cuticula loosen paste formulation speed of loosening it is too slow.The cutin newly born
Layer can also be affected, and become weak and loose.The cuticula of the present invention is loosened before cream has good clinical effectiveness and business
Scape.
The cream in addition, cuticula according to the above embodiment of the present invention is loosened, there can also be technical characteristic additional as follows：
As the preferred embodiment of the present invention, described cuticula is loosened cream, includes the raw material of following parts by weight：
0.1 part~1 part of pearl powder, 0.01 part~0.5 part of honeycomb, 0.01 part~1 part of Asian puccoon, thunder lock pungent 0.02 part~0.8 part and ice vinegar
0.05 part~1 part of acid.
As the preferred embodiment of the present invention, described cuticula is loosened cream, includes the raw material of following parts by weight：Sheep
30 parts of fat of hair, 60 parts of vaseline, 1 part of salicylic acid, 15 parts of benzoic acid, 5 parts of boric acid, 10 parts of kuh-seng, 0.1 part of pearl powder, honeycomb 0.5
Part, 0.01 part of Asian puccoon, thunder lock pungent 0.8 part and 0.05 part of glacial acetic acid.
As the preferred embodiment of the present invention, described cuticula is loosened cream, includes the raw material of following parts by weight：Sheep
50 parts of fat of hair, 40 parts of vaseline, 10 parts of salicylic acid, 3 parts of benzoic acid, 20 parts of boric acid, 1 part of kuh-seng, 1 part of pearl powder, honeycomb 0.01
Part, 1 part of Asian puccoon, thunder lock pungent 0.02 part and 1 part of glacial acetic acid.
As the preferred embodiment of the present invention, described cuticula is loosened cream, includes the raw material of following parts by weight：Sheep
40 parts of fat of hair, 50 parts of vaseline, 5 parts of salicylic acid, 9 parts of benzoic acid, 13 parts of boric acid, 5 parts of kuh-seng, 0.5 part of pearl powder, honeycomb 0.25
Part, 0.1 part of Asian puccoon, thunder lock pungent 0.4 part and 0.5 part of glacial acetic acid.
It is another object of the present invention to propose that described cuticula loosens the preparation method of cream.
Described cuticula is loosened the preparation method of cream, is comprised the following steps：S101：First by the lanolin and described
Vaseline mixes according to above-mentioned parts by weight；S102：The obtained mixtures of the step S101 are heated to 40 DEG C~60 DEG C simultaneously
1min~5min is stirred, then adds surplus stock component, continues to stir 10min~20min；S103：By the step S102
The temperature adjustment of obtained product obtains cuticula and loosened cream to room temperature.
Another object of the present invention is loosening cream in the composition for repairing skin is prepared in the cuticula described in proposing
Application.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Embodiments of the invention are described below in detail, the embodiment is exemplary, it is intended to for explaining the present invention, and
It is not considered as limiting the invention.
Embodiment 1
Embodiment 1 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：30 parts of lanolin, all scholars
10 parts of 60 parts of woods, 1 part of salicylic acid, 15 parts of benzoic acid, 5 parts of boric acid and kuh-seng.
The cuticula of embodiment 1 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 40 DEG C and stirs 5min, then add surplus stock group
Point, continue to stir 10min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Embodiment 2
Embodiment 2 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：50 parts of lanolin, all scholars
1 part of 40 parts of woods, 10 parts of salicylic acid, 3 parts of benzoic acid, 20 parts of boric acid and kuh-seng.
The cuticula of embodiment 2 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 60 DEG C and stirs 1min, then add surplus stock group
Point, continue to stir 20min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Embodiment 3
Embodiment 3 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：40 parts of lanolin, all scholars
5 parts of 50 parts of woods, 5 parts of salicylic acid, 9 parts of benzoic acid, 13 parts of boric acid and kuh-seng.
The cuticula of embodiment 3 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 50 DEG C and stirs 3min, then add surplus stock group
Point, continue to stir 15min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Embodiment 4
Embodiment 4 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：30 parts of lanolin, all scholars
60 parts of woods, 1 part of salicylic acid, 15 parts of benzoic acid, 5 parts of boric acid, 10 parts of kuh-seng, 0.1 part of pearl powder, 0.5 part of honeycomb, Asian puccoon 0.01
Part, thunder lock pungent 0.8 part and 0.05 part of glacial acetic acid.
The cuticula of embodiment 4 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 45 DEG C and stirs 4min, then add surplus stock group
Point, continue to stir 13min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Embodiment 5
Embodiment 5 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：50 parts of lanolin, all scholars
40 parts of woods, 10 parts of salicylic acid, 3 parts of benzoic acid, 20 parts of boric acid, 1 part of kuh-seng, 1 part of pearl powder, 0.01 part of honeycomb, 1 part of Asian puccoon, thunder
Lock pungent 0.02 part and 1 part of glacial acetic acid.
The cuticula of embodiment 5 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 55 DEG C and stirs 2min, then add surplus stock group
Point, continue to stir 18min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Embodiment 6
Embodiment 6 proposes a kind of cuticula and loosened cream, includes the raw material of following parts by weight：40 parts of lanolin, all scholars
50 parts of woods, 5 parts of salicylic acid, 9 parts of benzoic acid, 13 parts of boric acid, 5 parts of kuh-seng, 0.5 part of pearl powder, 0.25 part of honeycomb, 0.1 part of Asian puccoon,
Thunder lock pungent 0.4 part and 0.5 part of glacial acetic acid.
The cuticula of embodiment 6 is loosened the preparation method of cream, is comprised the following steps：
(1) lanolin and the vaseline are mixed according to above-mentioned parts by weight first.
(2) mixture that the step (1) obtains is heated to 48 DEG C and stirs 3min, then add surplus stock group
Point, continue to stir 14min.
(3) temperature adjustment for the product for obtaining the step (2) is to room temperature, obtains cuticula and loosens cream.
Comparative example 1
Comparative example 1 proposes a kind of cuticula and loosened cream, and comparative example 1 differs only in embodiment 1, comparative example 1
Boric acid and kuh-seng are not added in formula, remaining formula and step are same as Example 1.
Comparative example 2
Comparative example 2 proposes a kind of cuticula and loosened cream, and comparative example 2 differs only in embodiment 4, comparative example 2
Kuh-seng, honeycomb and Asian puccoon are not added in formula, remaining formula and step are same as Example 1.
In addition, the effect of in order to preferably evaluate each embodiment, carry out following test：
First, toxicity test
The small white mouse 160 (each 80 of male and female) for selecting body weight to be 18~22g, is divided into 8 groups, each 20 of every group of male and female, little Bai
Mouse back unhairing exposes exocuticle, and unhairing scope 2cm × 2cm, the 1st group to the 6th group is smeared the embodiment of the present invention 1 to implementation respectively
The cuticula that example 6 is prepared is loosened cream, and the 7th group and the 8th group is smeared angle prepared by comparative example 1 and comparative example 2 of the present invention respectively
Matter layer is loosened cream, dosage 0.2g, successive administration 36h.When during administration and 1 week after drug withdrawal, white mouse growth conditions are observed
And activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result all small white mouses are found
Health existence, it is without any side effects；Anatomic observation blood picture, liver function, each organs and tissues state, compared with normal small white mouse
Indifference.It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic, drug safety is reliable.
2nd, clinical test
The people of tinea of feet and hands patient 160 of fungal infection is randomly selected, smears the cutin of the embodiment of the present invention and comparative example respectively
Layer is loosened cream, per 4cm20.5g is smeared, is observed after 48h is administered.
Observation index：Recovery from illness：Cutin is loosened completely, and the cutin newly born is weak and loose；Effectively：Cutin part is discongested,
The cutin newly born is weaker；It is invalid：Cuticula is not loosened, and the cutin newly born is thicker, harder.It the results are shown in Table 1.(its
In, total effective rate=(effectively+recovery from illness)/total number of persons * 100%)
Table 1：The improvement situation of pretherapy and post-treatment patient clinical symptom
| Group | Recovery from illness/example | Effectively/example | Invalid/example | Total effective rate/% |
| Embodiment 1 | 17 | 1 | 2 | 90 |
| Embodiment 2 | 16 | 2 | 2 | 90 |
| Embodiment 3 | 15 | 2 | 3 | 85 |
| Embodiment 4 | 18 | 1 | 1 | 95 |
| Embodiment 5 | 17 | 2 | 1 | 95 |
| Embodiment 6 | 18 | 2 | 0 | 100 |
| Comparative example 1 | 0 | 1 | 19 | 5 |
| Comparative example 2 | 0 | 5 | 16 | 25 |
As it can be seen from table 1 the cuticula for smearing embodiment 1-6 is loosened the patient of the recovery from illness of cream at 15 and more than, always
Effective percentage up to more than 85%, and the loosen patient of cream of the cuticula for smearing comparative example 1-2 there is no recovery from illness, it is total effectively
Rate only has 25%.Embodiment has significant difference compared with comparative example.The cuticula of the embodiment of the present invention is loosened cream, effect
Substantially, adverse reaction is not found, it is safe to use, and be comfortable on after, patient medication's compliance is good.
The cuticula of the present invention lanolin added in cream of loosening can strengthen Medicated Permeation, coordinate vaseline composition sustained release
Base, rational formula salicylic acid, benzoic acid, boric acid, kuh-seng are thoroughly loose by the sustained release osmotic of 24 hours cuticula debonding agents
Solve the keratoderma at dispenser position.Can efficiently and rapidly be loosened keratoderma, be loosened from the topical application of drug to cuticula completely only
Need 48 hours, solve the problems, such as current various cuticula loosen paste formulation speed of loosening it is too slow.The cutin newly born
Layer can also be affected, and become weak and loose.The cuticula of the present invention is loosened before cream has good clinical effectiveness and business
Scape.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
Example ", or the description of " some examples " etc. mean to combine the specific features that the embodiment or example describe, structure, material or spy
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, the specific features of description, structure, material or feature can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the different embodiments or example and the feature of different embodiments or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, modification, replacement and modification.
Claims (7)
- The cream 1. a kind of cuticula is loosened, it is characterised in that include the raw material of following parts by weight：30 parts~50 parts of lanolin, it is all 1 part~10 parts of 40 parts~60 parts of intellectual circle, 1 part~10 parts of salicylic acid, 3 parts~15 parts of benzoic acid, 5 parts~20 parts of boric acid and kuh-seng.
- The cream 2. cuticula according to claim 1 is loosened, it is characterised in that also include the raw material of following parts by weight：It is precious 0.1 part~1 part of pearl powder, 0.01 part~0.5 part of honeycomb, 0.01 part~1 part of Asian puccoon, thunder lock pungent 0.02 part~0.8 part and glacial acetic acid 0.05 part~1 part.
- The cream 3. cuticula according to claim 2 is loosened, it is characterised in that include the raw material of following parts by weight：Wool 30 parts of fat, 60 parts of vaseline, 1 part of salicylic acid, 15 parts of benzoic acid, 5 parts of boric acid, 10 parts of kuh-seng, 0.1 part of pearl powder, honeycomb 0.5 Part, 0.01 part of Asian puccoon, thunder lock pungent 0.8 part and 0.05 part of glacial acetic acid.
- The cream 4. cuticula according to claim 2 is loosened, it is characterised in that include the raw material of following parts by weight：Wool 50 parts of fat, 40 parts of vaseline, 10 parts of salicylic acid, 3 parts of benzoic acid, 20 parts of boric acid, 1 part of kuh-seng, 1 part of pearl powder, 0.01 part of honeycomb, 1 part of Asian puccoon, thunder lock pungent 0.02 part and 1 part of glacial acetic acid.
- The cream 5. cuticula according to claim 2 is loosened, it is characterised in that include the raw material of following parts by weight：Wool 40 parts of fat, 50 parts of vaseline, 5 parts of salicylic acid, 9 parts of benzoic acid, 13 parts of boric acid, 5 parts of kuh-seng, 0.5 part of pearl powder, honeycomb 0.25 Part, 0.1 part of Asian puccoon, thunder lock pungent 0.4 part and 0.5 part of glacial acetic acid.
- The preparation method of cream 6. the cuticula described in claim any one of 1-5 is loosened, it is characterised in that comprise the following steps：S101：The lanolin and the vaseline are mixed according to above-mentioned parts by weight first；S102：The obtained mixtures of the step S101 are heated to 40 DEG C~60 DEG C and stir 1min~5min, are then added Surplus stock component, continue to stir 10min~20min；S103：By the temperature adjustment of the obtained products of the step S102 to room temperature, obtain cuticula and loosen cream.
- Application of the cream in the composition for repairing skin the is prepared 7. cuticula described in claim any one of 1-5 is loosened.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710976032.9A CN107595932A (en) | 2017-10-19 | 2017-10-19 | Cuticula is loosened cream and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710976032.9A CN107595932A (en) | 2017-10-19 | 2017-10-19 | Cuticula is loosened cream and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107595932A true CN107595932A (en) | 2018-01-19 |
Family
ID=61078741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710976032.9A Pending CN107595932A (en) | 2017-10-19 | 2017-10-19 | Cuticula is loosened cream and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107595932A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1486697A (en) * | 2003-09-01 | 2004-04-07 | 秦现杰 | Cream for treating keratosis and chap |
| CN101444588A (en) * | 2008-12-26 | 2009-06-03 | 漳州市健源堂生物工程有限公司 | Skin ointment and preparation method thereof |
| CN102379880A (en) * | 2010-08-30 | 2012-03-21 | 殷峰林 | Preparation method of compound benzoic acid ointment |
| CN103565916A (en) * | 2013-11-07 | 2014-02-12 | 成都九芝堂金鼎药业有限公司 | Traditional Chinese medicine composition for treating keratosis type tinea of feet and hands as well as preparation method thereof |
| CN104815065A (en) * | 2015-05-21 | 2015-08-05 | 张洪坤 | Medicine for treating skin tinea on hands and feet or skin pruritus and preparation method of medicine |
-
2017
- 2017-10-19 CN CN201710976032.9A patent/CN107595932A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1486697A (en) * | 2003-09-01 | 2004-04-07 | 秦现杰 | Cream for treating keratosis and chap |
| CN101444588A (en) * | 2008-12-26 | 2009-06-03 | 漳州市健源堂生物工程有限公司 | Skin ointment and preparation method thereof |
| CN102379880A (en) * | 2010-08-30 | 2012-03-21 | 殷峰林 | Preparation method of compound benzoic acid ointment |
| CN103565916A (en) * | 2013-11-07 | 2014-02-12 | 成都九芝堂金鼎药业有限公司 | Traditional Chinese medicine composition for treating keratosis type tinea of feet and hands as well as preparation method thereof |
| CN104815065A (en) * | 2015-05-21 | 2015-08-05 | 张洪坤 | Medicine for treating skin tinea on hands and feet or skin pruritus and preparation method of medicine |
Non-Patent Citations (1)
| Title |
|---|
| 金琳: "《内科护理学实践》", 28 February 2017, 天津科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104922130B (en) | It is a kind of to be used to treat gelling agent of herpes zoster and preparation method thereof | |
| CN108452275A (en) | It is a kind of to have effects that the composition, medicament and preparation method of relaxing tendons and activating collaterals | |
| CN100998575B (en) | Finger nail coating agent of antifungal agent and its preparing method | |
| CN104013878B (en) | A kind of lavipeditum medicine vinegar and preparation method thereof for treating tinea pedis | |
| CN107519236A (en) | A kind of topical agent for treating onychomycosis | |
| CN107595932A (en) | Cuticula is loosened cream and its preparation method and application | |
| CN106619987A (en) | Externally-applied agent for prevention and treatment of pruritus and eczema at female sensitive position | |
| CN1133723A (en) | Exterior-use traditional Chinese medicine ointment and its preparing method | |
| WO2015059572A1 (en) | A method for topically treating actinic keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate) | |
| CN107050060A (en) | Treat psoriasic externally applied drug and pharmaceutical composition | |
| CN100411674C (en) | A medicine for treating tinea pedis | |
| CN105982882B (en) | A kind of externally applied drug and preparation process of optical active starting materials composition prescription therapeutic hemorrhoid | |
| CN106266453A (en) | A kind of composition for external application and application thereof | |
| CN105168360A (en) | Compound plant extract liniment for treating acne and preparation method of compound plant extract liniment | |
| CN108210871A (en) | A kind of osmanthus green pepper ginger composition for treating pain | |
| CN1233331C (en) | Medicine for curing epilepsy by adopting head osmotic therapy | |
| CN1247227C (en) | External-use liposome prepn for treating mite-borne dermatosis | |
| CN117338889B (en) | Essential oil composition for preventing and treating blood stasis syndrome and application thereof | |
| CN108159269A (en) | A kind of medicament for being used to treat acne | |
| CN106074578A (en) | A kind of pharmaceutical composition treating acne and application thereof | |
| CN100389810C (en) | Medicine for eliminating acne | |
| US20160106797A1 (en) | Topical treatment of shingles | |
| CN105902992A (en) | Externally applied medicinal gel for treating onychomycosis and preparation method thereof | |
| CN112704720A (en) | Pharmaceutical composition with nail-dissolving effect and application thereof | |
| CN107693522A (en) | Application of the Ketoconazol/Clobetasol Propionate in the medicine for preparing treatment allergic dermatitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180119 |