CN103565727B - A kind of black Fructus Lycii moisturizing whitening cream and preparation method thereof - Google Patents
A kind of black Fructus Lycii moisturizing whitening cream and preparation method thereof Download PDFInfo
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- CN103565727B CN103565727B CN201310557610.7A CN201310557610A CN103565727B CN 103565727 B CN103565727 B CN 103565727B CN 201310557610 A CN201310557610 A CN 201310557610A CN 103565727 B CN103565727 B CN 103565727B
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- fructus lycii
- black fructus
- whitening cream
- moisturizing whitening
- water
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- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
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- 230000037067 skin hydration Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The invention provides a kind of black Fructus Lycii moisturizing whitening cream.Present invention also offers the preparation method of facial cream.Moisturizing whitening cream of the present invention, can effectively moisturizing moisturizing, horny layer softening, freckle removing and whitening, infiltration reparation, it is remarkable that to improve skin inwardness aging, prevent the problems such as the wrinkling and mottle of skin, also there is Promote cell's growth, absorb ultraviolet, the anti-ageing effect of waiting for a long time, waking skin vigor up, give the moisture feeling of skin water profit and abundant reflecting feel, and coating is felt, assimilation effect is excellent.The present invention is made up of pure natural substance, does not add pigment, does not stimulate, has no side effect containing ethanol, gentleness.
Description
Technical field
The present invention relates to a kind of black Fructus Lycii moisturizing whitening cream and preparation method thereof.
Background technology
Along with growth in the living standard, the requirement of people to cosmetics also improves thereupon, wish in cosmetics containing natural extract composition, the significant skin care item of effect.Moisturizer always is first-selection, because skin water deficient, profit secretion is uneven, and collagen protein can run off, and skin metabolism is slow, and the problem such as mottle, wrinkle can perplex skin, is unfavorable for further skin protection.
Moisturizing face cream has a variety of, but while moisturizing again can skin whitening, light speckle wrinkle removing, antioxidative facial cream rare, and some commercially available whitening products contain the material such as lead, hydrargyrum, to skin toxic side effect.
Summary of the invention
The object of the present invention is to provide a kind of with natural biological extract moisturizing whitening cream that is active component and preparation method thereof.
The invention provides a kind of black Fructus Lycii moisturizing whitening cream, it is prepared from by the supplementary material of following weight percentage:
Further, it is prepared from by the supplementary material of following weight percentage:
In the present invention, multiple natural extract is combinationally used, played more good skin care activity, for market provides the skin care item that a kind of skin effect is better, safety is high.
Wherein, described black Fructus Lycii seed oil passes through supercritical CO
2extraction gained, its preparation method is: take in black Fructus Lycii seed 400g loading 2L extraction kettle and carry out supercritical CO
2extraction, opens CO
2gas tank, pressurizes to extraction kettle, when extraction kettle pressure reaches required pressure, opens the pressure valve controlling separating still and regulates seamless power, regulate CO simultaneously
2flow, and keep temperature and pressure, then collect single extraction thing every 15min, weigh, black Fructus Lycii seed oil is collected by two-stage separation kettle, CO
2can be recycled.
Wherein, described black Fructus Lycii fruit powder extracting solution is the water extract of black Fructus Lycii fruit powder; Preferably, the preparation method of black Fructus Lycii extracting solution is as follows: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, extract 2 times in 50 DEG C of water-baths, each 15 minutes, the 100mL that added water by residue after filtration extracts 2 times at 75 DEG C, each 15 minutes, merge extracted twice liquid, filter, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
Wherein, the preparation method of yeast extract is as follows: by beer yeast washing impurity-removing matter, debitterize in 0-4 DEG C of water, carry out coarse filtration again, obtain the yeast slurry containing solid content, then add promoter, plasmolyticum and NaOH, regulate pH to 6.0 ~ 7.0, at 52 DEG C ± 2 DEG C temperature, 2-2.5 hour is extracted in self-dissolving, boil again, enzyme denaturing, cooling leave standstill, centrifugalize, removing cell wall fragments, vacuum-concentrcted is 10g/mL to concentration, obtains yeast extract.
Wherein, the preparation method of seaweed extracted liquor is as follows: the dilute acid soln being 2 ~ 4 by the Sargassum pH after the removal of impurity cleans, rub, and be grind homogenate in the dilute acid soln of 2 ~ 4 at pH, then by the Sargassum after homogenate temperature 121 ~ 135 DEG C, ripening sterilizing 0.5 ~ 2 hour under pressure 1 ~ 5MPa, Sargassum slurry after degraded adds alkali adjustment pH to 5.0-7.0, cultured probiotic bacteria strain normal fermentation is in advance inoculated in the Sargassum serosity after adjustment, in the serosity after fermentation, add algin oligosaccharide again to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
But the extracting method of various extract is not limited to said method, the extracting method manufacturing cosmetics-stage extract disclosed in all prior aries is all applicable to the present invention.
Wherein, described emulsifying agent is selected from one or more in sorbester p18, the stearic alcohol ether of polyoxyethylene-2 (21), polysorbate60, SS-5051, GLUCATE SS, Glucamate SSE-20, emulsifying agent M68.
Wherein, described antibacterial is selected from one or more in Kathon CG, Germall II, Germall Plus, GlydantPLUS.
Present invention also offers the preparation method of above-mentioned black Fructus Lycii moisturizing whitening cream, it comprises following operating procedure:
(1) raw material is taken by weight ratio;
(2) by cetostearyl alcohol, molecular distillation monoglyceride, sorbester p18, polysorbate60, emulsifying agent, liquid paraffin, caprylic/capric triglyceride, polydimethylsiloxane, vaseline, propylparaben heated and stirred in the water-bath of 85 DEG C ± 5 DEG C, oil-phase solution is obtained;
(3) disodiumedetate, glycerol, 1,3 butylene glycol, allantoin, methyl hydroxybenzoate and water are made dissolving the stirred in water bath of 85 DEG C ± 5 DEG C, obtain aqueous phase solution;
(4) oil-phase solution is slowly joined in aqueous phase solution, emulsifying 5 ~ 8 minutes in 85 DEG C ± 5 DEG C water-baths, then add emulsifying agent match Bick 305 continue emulsifying 3 ~ 5 minutes;
(5) continue to stir, when thing to be mixed is cooled to 40 ~ 50 DEG C, adds black Fructus Lycii seed oil, vitamin E, black Fructus Lycii fruit powder extracting solution, yeast extract, seaweed extracted liquor, antibacterial and essence, fully stir, make its mix homogeneously, obtain black Fructus Lycii moisturizing whitening cream.
The present invention is strong in order to prepare moisture retention, and there is the facial cream of the effect such as whitening, desalination mottle, defying age, Glycerin simultaneously, adopt black Fructus Lycii seed oil, black Fructus Lycii fruit powder extracting solution, yeast extract, seaweed extracted liquor as main active, and with other material combination, join in conventional cosmetic ingredients according to a certain percentage and make.
Wherein, in black Fructus Lycii seed oil, be rich in linoleic acid, oleic acid, gamma-Linolenic acid, vitamin E, beta-carotene, phospholipid, and containing various trace elements and bioactive substance epidermal growth factor, superoxide dismutase (SOD) etc.Linoleic acid, gamma-Linolenic acid etc. are all natural unsaturated fatty acids.Vitamin E is a kind of very strong antioxidant; restraint of tyrosinase is active; reduce melanic formation; anti-lipid peroxidation reacts; keep contact between tissue; make skin smooth, flexible; energy Cell protection film is from the oxidative damage of free radical; so can help to repair and consolidate the natural protective barrier of skin; pin moisture in skin, provide deep layer from inside to outside to nourish, the absorption of vitamin C and A can also be promoted; and help cell to absorb the nutritional labeling of outside skin care item better, beauty functions is doubled.Beta-carotene can promote human immunity defense function and slow down aging.Superoxide dismutase (SOD) can antiradiation injury, is highly resistant to again peroxide anion free radical, has anti-aging effects.Through a large amount of clinical verification, boxthorn seed oil has following effect: boxthorn seed oil can reduce plasma cholesterol, reduces cholesterol level in blood vessel wall, prevents blood fat and atherosclerosis; Can cutaneous circulation be promoted, participate in skin metabolism directly, eliminate oxygen-derived free radicals, delay the aging of epidermis and corium, strengthen skin hydration function, make skin emolliency and high resilience, have obvious whitening effect; The effect of taking off that significantly disappears is had to senile plaque and chloasma pigment calmness.
Black Fructus Lycii extracting solution is the water extract of black Fructus Lycii fruit powder.The composition such as rich in proteins, aminoacid, flavone, procyanidin, fat, polysaccharide, vitamin E in lycium ruthenicum fruit.Protein is the structural material of human body skin, gives skin with nutrition, can make impaired cell, tissue obtain timely high-quality repairing, make the high resilience of skin gloss, delaying senility.Containing 17 seed amino acids except tryptophan except in lycium ruthenicum fruit, aminoacid is formation organism protein and with one of closely bound up most base substance of vital movement, can provides nutrition, growth promoting effects, the normal metabolism of maintenance.Assessment of Pigment of Lycium ruthenicum Murr is anthocyanin class and flavone compound, and its non-oxidizability is obviously better than than vitamin E, and has Stabilization to visible ray and ultraviolet.The non-oxidizability of flavone is mainly manifested in the aspect such as scavenging free radicals and anti-peroxidation.
Yeast extract is rich in the material of the active skull cap components such as micromolecular aminoacid, peptide, nucleotide, vitamin, wherein amino acid content more than 30%, total protein more than 50%, nucleotide more than 10%.Nucleic acid and nucleotide are the central genetic materials of human body, there is enhancing metabolism, improve the effects such as protein synthesis speed, strengthen immune function, enhance SOD activity, improve skin antiradical activities, skin-nourishing is provided, adjustment sebum secretion, promote collagen protein synthesis, smooth away wrinkles, isolation radiation, prevents ultra-violet absorption.In addition, the nutrients such as a small amount of in product vitamin and mineral can also provide sufficient nutrition for skin.
Seaweed extracted liquor is a kind of marine organisms product of pure natural, include abundant algin acid, crude protein, multivitamin, enzyme, trace element etc., these nutrients can reduce skin surface blood fat after skin absorbs, promote the hemopoietic function of epidermis cell, bacteriostasis can be produced to cell in vitro, also there is moisturizing, smooth function.In addition, a large amount of aniones contained, can stimulate fibrocyte to generate collagen protein and elastin laminin, promote the metabolism of skin, impart its crease-resistant, antidotal effect.
Moisturizing whitening cream of the present invention, can effectively moisturizing moisturizing, horny layer softening, freckle removing and whitening, infiltration reparation, it is remarkable that to improve skin inwardness aging, prevent the problems such as the wrinkling and mottle of skin, also there is Promote cell's growth, absorb ultraviolet, the anti-ageing effect of waiting for a long time, waking skin vigor up, give the moisture feeling of skin water profit and abundant reflecting feel, and coating is felt, assimilation effect is excellent.The present invention is made up of pure natural substance, does not add pigment, does not stimulate, has no side effect containing ethanol, gentleness.
Below by way of detailed description of the invention; scope of the present invention is further elaborated and is illustrated; but protection scope of the present invention is not limited thereto; any those of ordinary skill in the art are in the technical scope disclosed by the present invention; without the amendment of creative work or replacement, all should be able to be encompassed within protection scope of the present invention.
Detailed description of the invention
The preparation method of yeast extract is as follows: by beer yeast washing impurity-removing matter, debitterize in 0-4 DEG C of water, carry out coarse filtration again, obtain the yeast slurry containing solid content, then promoter, plasmolyticum and NaOH is added, regulate pH to 6.0 ~ 7.0, at 52 DEG C ± 2 DEG C temperature self-dissolving extract 2-2.5 hour, then boil, enzyme denaturing, cooling leave standstill, centrifugalize, removing cell wall fragments, vacuum-concentrcted is 10g/mL to concentration, obtains yeast extract.
The preparation method of seaweed extracted liquor is as follows: the dilute acid soln being 2 ~ 4 by the Sargassum pH after the removal of impurity cleans, rub, and be grind homogenate in the dilute acid soln of 2 ~ 4 at pH, then by the Sargassum after homogenate temperature 121 ~ 135 DEG C, ripening sterilizing 0.5 ~ 2 hour under pressure 1 ~ 5MPa, Sargassum slurry after degraded adds alkali adjustment pH to 5.0-7.0, cultured probiotic bacteria strain normal fermentation is in advance inoculated in the Sargassum serosity after adjustment, in the serosity after fermentation, add algin oligosaccharide again to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
The black Fructus Lycii seed oil used in the present invention is the general raw material of cosmetic industry, can buy on cosmetic material market, also can obtain with reference to prior art preparation, such as: pass through supercritical CO
2obtained by extraction, its concrete preparation method can be: take in black Fructus Lycii seed 400g loading 2L extraction kettle and carry out supercritical CO
2extraction, opens CO
2gas tank, pressurizes to extraction kettle, when extraction kettle pressure reaches required pressure, opens the pressure valve controlling separating still and regulates seamless power, regulate CO simultaneously
2flow, and keep temperature and pressure, then collect single extraction thing every 15min, weigh, black Fructus Lycii seed oil is collected by two-stage separation kettle, CO
2can be recycled.Black Fructus Lycii seed oil also can be extracted by modes such as squeezings and obtain.
The black Fructus Lycii extracting solution that the present invention uses is the water extract of black Fructus Lycii fruit powder, its concrete preparation method can be: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, extract 2 times in 50 DEG C of water-baths, each 15 minutes, the 100mL that added water by residue after filtration extracts 2 times at 75 DEG C, each 15 minutes, merge extracted twice liquid, filter, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
Concentration after concentrated in the present invention is all the ratio calculating gained with the mass/volume of concentrated solution.
In the embodiment of the present invention, each component is listed in table 1, and proportional quantity is with mass percent example.
Table 1
The preparation method of the embodiment of the present invention is all according to following steps:
(1) raw material is taken by weight ratio;
(2) by cetostearyl alcohol, molecular distillation monoglyceride, sorbester p18, polysorbate60, emulsifying agent, liquid paraffin, caprylic/capric triglyceride, polydimethylsiloxane, vaseline, propylparaben heated and stirred in the water-bath of 85 DEG C ± 5 DEG C, oil-phase solution is obtained;
(3) disodiumedetate, glycerol, 1,3 butylene glycol, allantoin, methyl hydroxybenzoate and water are made dissolving the stirred in water bath of 85 DEG C ± 5 DEG C, obtain aqueous phase solution;
(4) oil-phase solution is slowly joined in aqueous phase solution, emulsifying 5 ~ 8 minutes in 85 DEG C ± 5 DEG C water-baths, then add emulsifying agent match Bick 305 continue emulsifying 3 ~ 5 minutes;
(5) continue to stir, when thing to be mixed is cooled to 40 ~ 50 DEG C, adds black Fructus Lycii seed oil, vitamin E, black Fructus Lycii fruit powder extracting solution, yeast extract, seaweed extracted liquor, antibacterial and essence, fully stir, make its mix homogeneously, obtain black Fructus Lycii moisturizing whitening cream.
Embodiment 8
The Detection of Stability of the embodiment of the present invention 5 product:
1, pH value is 6.4.
2, heat resistant test, puts into calorstat (40 ± 1) DEG C the sample of Packing Intact and keeps 24h, returns to after room temperature without oil-water separation phenomenon.
3, low temperature resistant test, puts into-5 ~-10 DEG C, refrigerator the sample of Packing Intact and places 24h, return to after room temperature without layering, coarse, metachromatism.
4, centrifugal test, places the sample of Packing Intact with 2000 revs/min in centrifuge, centrifugal 30 minutes, without oil-water separation phenomenon.
As can be seen here, the facial cream that prepared by the embodiment of the present invention 5 has good stability.
Embodiment 9 clinical experiment of the present invention and result
Experimental subject: select age bracket aspiration trier 40 people of 32 ~ 48 years old, be divided into 2 groups at random, test group and matched group, often organize 20 people.
Experimental technique: test group trier carries out clean process before sleeping every night, the facial cream uniform application then embodiment 5 prepared is in face, and experimental period is one month.Matched group trier carries out clean process before sleeping every night, then by the facial cream uniform application obtained by embodiment 1 in face, experimental period is one month.Within every 7 days, 15 days, 30 days, respectively add up a result on trial.
Evaluation criterion: effectively represent that skin water profit is glossy, tender flexible in vain, obviously desalinate mottle, microgroove also makes moderate progress; Invalid representation skin texture with experiment before and be not any change; General expression skin quality makes moderate progress, but effect is not very remarkable, between the two above-mentioned.
Table 2
Result on trial: after 7 days, the product prepared by embodiment 5 has the moisturizing whitening effect being obviously better than being removed the product prepared by embodiment, and test group 14 example is effective, effective percentage 70%, and matched group 9 is routine, effective percentage 45%; After 15 days, test group 18 example is effective, effective percentage 90%, and matched group 12 example effectively, effective percentage 60%; After 30 days, test group 20 example is effective, effective percentage 100%, and matched group 15 example effectively, effective percentage 75%.Test group trier skin significantly increases glossiness, and fine and smooth water profit, also has whitening function, desalination mottle.An example is not had to occur the reaction such as skin allergy, discomfort.
As can be seen here, the product prepared by embodiment 5, excellent effect.
Claims (10)
1. a black Fructus Lycii moisturizing whitening cream, is characterized in that: it is prepared from by the supplementary material of following weight percentage:
2. black Fructus Lycii moisturizing whitening cream according to claim 1, is characterized in that: described black Fructus Lycii seed oil passes through supercritical CO
2extraction gained.
3. black Fructus Lycii moisturizing whitening cream according to claim 1, is characterized in that: the preparation method of black Fructus Lycii seed oil is: take in black Fructus Lycii seed 400g loading 2L extraction kettle and carry out supercritical CO
2extraction, opens CO
2gas tank, pressurizes to extraction kettle, when extraction kettle pressure reaches required pressure, opens the pressure valve controlling separating still and regulates seamless power, regulate CO simultaneously
2flow, and keep temperature and pressure, then collect single extraction thing every 15min, weigh, black Fructus Lycii seed oil is collected by two-stage separation kettle, CO
2can be recycled.
4. black Fructus Lycii moisturizing whitening cream according to claim 1, is characterized in that: described black Fructus Lycii fruit powder extracting solution is the water extract of black Fructus Lycii fruit powder.
5. black Fructus Lycii moisturizing whitening cream according to claim 1, it is characterized in that: the preparation method of black Fructus Lycii extracting solution is as follows: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, extract 2 times in 50 DEG C of water-baths, each 15 minutes, the 100mL that added water by residue after filtration extracts 2 times at 75 DEG C, each 15 minutes, the extracting solution at merging 50 DEG C and 75 DEG C, filtered, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
6. black Fructus Lycii moisturizing whitening cream according to claim 1, it is characterized in that: the preparation method of yeast extract is as follows: by beer yeast washing impurity-removing matter, debitterize in 0-4 DEG C of water, carry out coarse filtration again, obtain the yeast slurry containing solid content, then promoter, plasmolyticum and NaOH is added, regulate pH to 6.0 ~ 7.0, at 52 DEG C ± 2 DEG C temperature, 2-2.5 hour is extracted in self-dissolving, boil again, enzyme denaturing, cooling leave standstill, centrifugalize, removing cell wall fragments, vacuum-concentrcted is 10g/mL to concentration, obtains yeast extract.
7. black Fructus Lycii moisturizing whitening cream according to claim 1, it is characterized in that: the preparation method of seaweed extracted liquor is as follows: the dilute acid soln being 2 ~ 4 by the Sargassum pH after the removal of impurity cleans, rub, and be grind homogenate in the dilute acid soln of 2 ~ 4 at pH, then by the Sargassum after homogenate temperature 121 ~ 135 DEG C, ripening sterilizing 0.5 ~ 2 hour under pressure 1 ~ 5MPa, Sargassum slurry after degraded adds alkali adjustment pH to 5.0-7.0, cultured probiotic bacteria strain normal fermentation is in advance inoculated in the Sargassum serosity after adjustment, in the serosity after fermentation, add algin oligosaccharide again to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
8. black Fructus Lycii moisturizing whitening cream according to claim 1, is characterized in that: described emulsifying agent is selected from one or more in A165, the stearic alcohol ether of polyoxyethylene-2 (21), SS-5051, GLUCATE SS, Glucamate SSE-20, emulsifying agent M68.
9. Radix osteomelis schwerinais structure Qi moisturizing whitening cream according to claim 1, is characterized in that: described antibacterial is selected from one or more in Kathon CG, Germall II, Germall Plus, Glydant PLUS.
10. the preparation method of black Fructus Lycii moisturizing whitening cream described in claim 1 ~ 9 any one, is characterized in that: it comprises following operating procedure:
(1) supplementary material is taken by weight ratio;
(2) by cetostearyl alcohol, molecule distillating monoglyceride, sorbester p18, polysorbate60, emulsifying agent, liquid paraffin, caprylic/capric triglyceride, polydimethylsiloxane, vaseline, propylparaben heated and stirred in the water-bath of 85 DEG C ± 5 DEG C, oil-phase solution is obtained;
(3) disodiumedetate, glycerol, 1,3 butylene glycol, allantoin, methyl hydroxybenzoate and water are made dissolving the stirred in water bath of 85 DEG C ± 5 DEG C, obtain aqueous phase solution;
(4) oil-phase solution is slowly joined in aqueous phase solution, emulsifying 5 ~ 8 minutes in 85 DEG C ± 5 DEG C water-baths, then add emulsifying agent match Bick 305 continue emulsifying 3 ~ 5 minutes;
(5) continue to stir, when thing to be mixed is cooled to 40 ~ 50 DEG C, adds black Fructus Lycii seed oil, vitamin E, black Fructus Lycii fruit powder extracting solution, yeast extract, seaweed extracted liquor, antibacterial and essence, fully stir, make its mix homogeneously, obtain black Fructus Lycii moisturizing whitening cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213261A (en) * | 2015-10-28 | 2016-01-06 | 青海尤尼克生物技术有限公司 | A kind of black fruit matrimony vine oxidation resistant skin care item |
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| CN106344481A (en) * | 2016-08-26 | 2017-01-25 | 周讯 | Moisturizing face cream and preparation method thereof |
| CN106265437A (en) * | 2016-08-31 | 2017-01-04 | 青海新泰行生物科技有限公司 | A kind of cosmetic composition containing black Fructus Lycii extract and element face frost |
| CN109925213A (en) * | 2017-12-15 | 2019-06-25 | 四川吉鼎科技有限公司 | A kind of crease-resistant light spot face cream |
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| CN110540562B (en) * | 2019-09-04 | 2022-11-04 | 江苏省中国科学院植物研究所 | Application of lycium ruthenicum anthocyanin in cosmetics with whitening effect |
| CN110777009A (en) * | 2019-11-07 | 2020-02-11 | 高艳艳 | Infant enzyme laundry detergent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991709A (en) * | 2010-11-09 | 2011-03-30 | 中国科学院西北高原生物研究所 | Method for preparing antioxidant lycium ruthenicum extract |
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| CN101991709A (en) * | 2010-11-09 | 2011-03-30 | 中国科学院西北高原生物研究所 | Method for preparing antioxidant lycium ruthenicum extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105213261A (en) * | 2015-10-28 | 2016-01-06 | 青海尤尼克生物技术有限公司 | A kind of black fruit matrimony vine oxidation resistant skin care item |
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