CN105193694A - Skin care product with whitening and freckle-removing functions - Google Patents
Skin care product with whitening and freckle-removing functions Download PDFInfo
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- CN105193694A CN105193694A CN201510725022.9A CN201510725022A CN105193694A CN 105193694 A CN105193694 A CN 105193694A CN 201510725022 A CN201510725022 A CN 201510725022A CN 105193694 A CN105193694 A CN 105193694A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides a skin care product with whitening and freckle-removing functions. In terms of total weight of the skin care product, the skin care product comprises components as follows: 0.0001%-0.001% of rhEGF (recombinant human epidermal growth factor), 0.2%-0.8% of olive oil, 0.35%-0.1% of artemia extract and 0.20%-0.6% of rhizoma phragmitis aqueous extract. According to the skin care product with the whitening and freckle-removing functions, the olive oil, the artemia extract and the rhizoma phragmitis aqueous extract are compounded with the rhEGF, so that rhEGF inactivation can be effectively avoided, rhEGF efficiency is greatly improved, meanwhile, rhEGF absorption can be promoted, and rhEGF loss in a penetration process is reduced. The skin care product added with skin care composition with the whitening and freckle-removing functions can promote regenerative skin cells to replace and renew senescent cells, can reduce content of melanin and colored corpuscles in the skin cells and relieves skin pigmentation, and the whitening and freckle-removing purposes are achieved.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of whitening and speckle dispelling skin care item.
Background technology
Epidermal growth factor (EGF) is a kind of multi-functional Growth of Cells promotive factor, there is Promote cell's growth widely active, accelerate human skin cell's speed of growth, promoting the new Growth of Cells breeding of skin, is the deciding factor affecting skin health.But with advancing age and the deterioration of environment, in human body, the content of EGF reduces gradually, causes skin health impaired.Natural EGF is extensively present in mammalian body, and its content is low, and extract difficulty large, cost is high, and people adopt rhEGF to substitute natural EGF usually.RhEGF can stimulate the various cells of outer embryo rhEGF layer and endodermal origin as cornea, epithelium etc., makes it breed.Its biological effect comprises: 1) promote that low molecular weight compound is initiatively transported in cell from extracellular, increase the nutrient substance of cell; 2) glycolysis is activated to increase respiratory metabolism, energy activating phosphatase fructokinase; 3) the outer macromolecular synthesis of irritation cell, as hyaluronic acid and glycoprotein.4) synthesis of RNA and protein is activated; 5) synthesis of DNA is promoted; 6) some materials of body are as the synthesis of fruit acid, prostaglandin to promote cell proliferation to promote.These biological effects show, rhEGF, by conducted signal, causes a series of Biochemical changes in cell, starts the gene relevant with cell division, makes akinete enter cell division phase, thus make cell proliferation.RhEGF promotes that neoplastic skin cell substitutes, upgrades senile cell, the content of melanin and coloured corpuscle in Skin Cell can be reduced, alleviate the calmness of skin pigment, the pigment situation of skin can be improved in Skin Cell level, so just can reach the object of whitening, speckle dispelling.There are the skin care item containing rhEGF in prior art, to aspects such as whitening and speckle dispelling, there is certain positive effect.Because external source rhEGF occurs Physical Loss or Damage and inactivation in the processes such as skin permeation, make the content of rhEGF in skin care item will far beyond EGF concentration several times in human body even hundreds of times just can produce a desired effect, through skin verification experimental verification, the effect that can control symptom clinically just can be reached when the concentration of rhEGF is 100 μ g/ml in skin care item, when the concentration of rhEGF is 300 more than μ g/ml, clinical symptoms just starts to take a turn for the better.In skin care item, the addition of rhEGF is too high, but inefficiency, considerably increase production cost.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of whitening and speckle dispelling skin care item, these skin care item comprise rhEGF and olive oil, artemia extract and Rhizoma Phragmitis water extract, four kinds of compositions are composite has significant cooperative effect for this, significantly can increase skin elasticity, improve skin moisturizing degree.
Technical scheme provided by the invention is whitening and speckle dispelling skin care item, and it is made up of rhEGF, olive oil, artemia extract and Rhizoma Phragmitis water extract.
Artemia (ARTEMIA) extract is a kind of halomereid extract; containing rich in protein and polypeptide; in addition also containing GP4G; after entering human body; ATP can be changed into rapidly; makeup energy instantaneously; wake up because of old and feeble or the affected by environment and cell of dormancy; activate various physiological activity and the metabolism of Skin Cell; improve the protein synthesis played a crucial role in epidermis; the function also having DNA protection and repair, plays an important role to numerous cell metabolism procedure.The parameters of artemia extract is: transparency liquid, ph (20 DEG C) 5.0 ~ 6.0; Density (20 DEG C) 1.00 ~ 1.02g/cm
3; Refractive index (20 DEG C) 1.33 ~ 1.34; Solid content: 12.0 ~ 18g/kg; GP4G content 145 ~ 195ppm.
Rhizoma Phragmitis water extract is pulled an oar by Rhizoma Phragmitis, is the ratio extracting in water 1 ~ 3 time of 1:5 ~ 10, extracts 1 ~ 3h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.10 ~ 1.30, to obtain final product.
Olive oil be the fruit of olive tree (OleaeuropaeaL.) through squeezing refinement, its fatty acid and multiple natural grease soluble vitamin are very favourable to nourishing skin.Wrinkle of skin and coarse can be prevented, make skin recover natural elasticity, gloss and tender.
With the total restatement of these skin care item, the weight content of said components is respectively: rhEGF0.0001 ~ 0.001%, olive oil 0.2 ~ 0.8%, artemia extract 0.35 ~ 1%, Rhizoma Phragmitis water extract 0.20 ~ 0.6%.
As preferably, said components is respectively at the weight content of this skin protection kind: rhEGF0.005%, olive oil 0.4%, artemia extract 0.6% and Rhizoma Phragmitis water extract 0.4%.
Described skin care item are whitening and speckle dispelling cream or whitening and speckle dispelling emulsion.The conventional formulation of whitening and speckle dispelling cream/emulsion:
rhEGF0.0001～0.001％；
Olive oil 0.2 ~ 0.8%;
Artemia extract 0.35 ~ 1%;
Rhizoma Phragmitis water extract 0.20 ~ 0.6%;
Emulsifying agent: 0.5 ~ 10%;
Emollient: 5 ~ 40%;
Excipient thickening agent: 0.1 ~ 10%;
Wetting agent: 5 ~ 30%;
Antiseptic: convention amount;
Antioxidant: convention amount;
Deionized water: surplus.
The preparation method of described skin care item is: first undertaken primary emulsifying by oil phase in skin care item and aqueous phase, adjust the temperature of this emulsification system 35 ~ 40 DEG C time, add rhEGF, olive oil, artemia extract and Rhizoma Phragmitis water extract, system is through stirring, and further cooling is up to the standards discharging.
Compared with prior art, the present invention has following beneficial effect:
1) artemia extract is similar to rhEGF with the peptide bond structure of Rhizoma Phragmitis water extract; very easily intersect between peptide bond, coil, the reaction of the space displacement such as compositions; rhEGF is surrounded by the peptide molecule key ring-type of artemia extract and Rhizoma Phragmitis water extract; protect rhEGF space structure; avoid rhEGF inactivation, greatly raise the efficiency.
2) olive oil, artemia extract and Rhizoma Phragmitis water extract itself all have effect of moisturizing, reduce wrinkle, greatly can improve skin care compositions moisturizing moisturizing, the effect of skin whitening and desalination mottle.
3) olive oil, artemia extract and Rhizoma Phragmitis water extract are the skin penetration enhancers be easily absorbed by the skin, and rhEGF is combined with olive oil, artemia extract and Rhizoma Phragmitis water extract and is very easily absorbed by the skin, and reduce the rhEGF loss in process of osmosis.
4) in skin care item of the present invention, the weight content of rhEGF is only 1 ~ 10 μ g/ml, well below conventional addition, conveniently consumption is applied on the face, neoplastic skin cell can be promoted substitute, upgrade senile cell, the content of melanin and coloured corpuscle in Skin Cell can be reduced, alleviate the calmness of skin pigment, reach the object of whitening, speckle dispelling.
Detailed description of the invention
The present invention is further elaborated for following specific embodiment, but not as a limitation of the invention.
Embodiment 1
The formula following (w%) of whitening and speckle dispelling cream:
rhEGF0.0001％；
Olive oil 0.2%;
Artemia extract 0.35%;
Rhizoma Phragmitis water extract 0.20%;
Glyceryl stearate: 3%;
Cetearyl alcohol: 5%;
Glycerol: 10%;
Propylene glycol: 10%;
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%;
Ceteth-20:1%;
Cocoanut oil alcohol sodium sulfovinate: 0.5%;
Hydroxyethyl-cellulose: 0.7%;
Antiseptic: appropriate;
Essence: appropriate;
Deionized water: surplus.
Rhizoma Phragmitis water extract is pulled an oar by Rhizoma Phragmitis, is the ratio extracting in water 3 times of 1:5, extracts 3h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.30, to obtain final product.
Preparation method:
1) in oil phase process tank, oil phase material (propylene glycol, cetearyl alcohol, glyceryl stearate, hydrogenation gather certain herbaceous plants with big flowers alkene) is dropped in still, starts agitator simultaneously, be heated to 92 ~ 98 DEG C, start agitator simultaneously, material is melted completely;
2) in aqueous phase pretreatment tank, glycerol is all dropped in still, start stirring, and hydroxyethyl-cellulose is slowly dropped in still in powder form, it is made fully to disperse, then other aqueous phases (water, ceteth-20, cocoanut oil alcohol sodium sulfovinate) are dropped in still, be heated to 92 ~ 98 DEG C, be stirred to evenly;
3) filtered oil phase suck into preheating emulsion tank in, rear suction aqueous phase, and start scraper plate stirring, rapid stirring, homogenizer (start emulsifying kettle rapid stirring and homogenizer about 10 ~ 12 minutes) with this, now emulsifying temperature in the kettle should not lower than 85 DEG C.After carrying out vacuum emulsification, insulated and stirred after 10 ~ 15 minutes, then starts chiller cooling.
4) when temperature drops to 55 ~ 60 DEG C, add essence, temperature drops to 35 ~ 40 DEG C, adds rhEGF, olive oil, artemia extract and Rhizoma Phragmitis water extract, antiseptic, continues to stir, when temperature continues to be down to 30 DEG C, and discharging after the assay was approved.
Embodiment 2
The formula following (w%) of whitening and speckle dispelling cream:
rhEGF0.001％
Olive oil 0.8%
Artemia extract 1%
Rhizoma Phragmitis water extract 0.6%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Rhizoma Phragmitis water extract is pulled an oar by Rhizoma Phragmitis, is the ratio extracting in water 1 time of 1:10, extracts 1h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.10, to obtain final product.
The preparation method of the whitening and speckle dispelling cream of the present embodiment is consistent with the preparation method of embodiment 1.
Embodiment 3
The formula following (w%) of whitening and speckle dispelling cream:
rhEGF0.005％
Olive oil 0.4%
Artemia extract 0.6%
Rhizoma Phragmitis water extract 0.4%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Rhizoma Phragmitis water extract is pulled an oar by Rhizoma Phragmitis, is the ratio extracting in water 2 times of 1:8, extracts 2h, merge extractive liquid, at every turn, filter in solid-liquid ratio, and when filtrate being concentrated into 50 DEG C, relative density is the extractum of 1.25, to obtain final product.
The preparation method of the whitening and speckle dispelling cream of the present embodiment is consistent with the preparation method of embodiment 1.
Reference examples 1
The formula following (w%) of whitening and speckle dispelling cream:
RhEGF lyophilized powder: 0.01%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 2
The formula following (w%) of whitening and speckle dispelling cream:
RhEGF lyophilized powder: 0.01%
Olive oil: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 3
The formula following (w%) of whitening and speckle dispelling cream:
RhEGF lyophilized powder: 0.01%
Olive oil: 0.3%
Artemia extract: 0.5%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
Its preparation method is identical with embodiment 1.
Reference examples 4
The formula following (w%) of whitening and speckle dispelling cream:
RhEGF lyophilized powder: 0.01%
Olive oil: 0.3%
Rhizoma Phragmitis water extract: 0.3%
Glyceryl stearate: 3%
Cetearyl alcohol: 5%
Glycerol: 10%
Propylene glycol: 10%
Hydrogenation gathers certain herbaceous plants with big flowers alkene: 5%
Ceteth-20:1%
Cocoanut oil alcohol sodium sulfovinate: 0.5%
Hydroxyethyl-cellulose: 0.7%
Antiseptic: appropriate
Essence: appropriate
Deionized water: surplus.
The preparation of Rhizoma Phragmitis water extract is identical with embodiment 1, and the preparation method of this cream is identical with embodiment 1.
Experimental example 1
For verifying the effect of skin care item of the present invention in whitening and speckle dispelling, selecting 70 volunteers to carry out effectiveness experiment, adopting double-dummy design, contrast experiment, carry out contrast and investigate.70 volunteers do not limit for men and women, healthy population, and the age, 10 people one group, were divided into 7 groups at random between 22 ~ 49 years old.Be respectively experimental group 1 ~ 3, matched group 1 ~ 4.Experimental group 1 ~ 3 uses the whitening and spot eliminating cream of the embodiment of the present invention 4 ~ 6 respectively, and matched group 1 ~ 4 uses the whitening and spot eliminating cream of reference examples 1 ~ 4 respectively.The whitening and spot eliminating cream that 7 groups of early, middle and late uses are for each person every day once described, using method spreads upon face in right amount for getting, and loops gently to absorbing completely.Experimental period is 3 weeks.
Use color difference meter to often organize each experimenter measure use before and after the brightness of skin (represent by aberration meansigma methods, aberration meansigma methods is larger, show that skin is brighter), and by following standard, observe the effect of whitening freckle cream to face's freckle and speckle.
Evaluation criterion:
Effectively-speckle, freckle obviously go down;
Effective-speckle and freckle slightly go down;
Invalid-unchanged.
Evaluation result:
As seen from the above table, experimental group is better than the whitening and speckle dispelling effect of matched group.
Experimental example 2
The white-skinned face function of extract is verified by external Tyrosinase inhibition assays.In melanic forming process, tryrosinase plays a crucial role, melanin produce number have direct relation with the activity of tryrosinase, skin-whitening agents is generally by acting in dermal melanin generation, metabolic process remittance, the generation of check melanin, accelerates melanic metabolism and plays the effect of skin whitening.
The skin care compositions with Whitening, spot effect of experimental group 1 ~ 3, matched group 1 ~ 4 is made into respectively the solution of 1%, ultrasonic assistant dissolves 1h, gets supernatant for subsequent use as sample.According to following table 2 application of sample, mixing, 37 DEG C of water bath heat preservation 10min, add the TYR enzyme liquid 0.5ml that concentration is 100U/ml in C1 and T1 pipe, mixing.Make the light absorption value of reference side C1 at 475nm place with C2 after 10 minutes, make reference with T2 and survey the light absorption value of T1 at 475nm place.C1 is the control reaction system not adding sample, and C2 is the reference liquid of C1, and T1 is the reaction system adding testing sample, and T2 is the reference liquid of corresponding T1.Utilize formulae discovery sample to the suppression ratio of tryrosinase.
Suppression ratio=(the C1-T1)/C1 of tryrosinase.
| C1 | C2 | T1 | T2 | |
| TYR | 1 | 1 | 1 | 1 |
| Sample | 0 | 0 | 1 | 1 |
| Phosphate buffer | 1.5 | 2 | 0.5 | 1 |
| Suppression ratio | |
| Matched group 1 | 38％ |
| Matched group 2 | 45％ |
| Matched group 3 | 48％ |
| Matched group 4 | 50％ |
| Experimental group 1 | 90％ |
| Experimental group 2 | 91％ |
| Experimental group 3 | 93％ |
As seen from the above table, the tyrosinase inhibition rate of experimental group is obviously better than matched group.
Claims (4)
1. whitening and speckle dispelling skin care item, is characterized in that: it comprises rhEGF, olive oil, artemia extract and Rhizoma Phragmitis water extract.
2. whitening and speckle dispelling skin care item according to claim 1, it is characterized in that: with the total restatement of these skin care item, the weight content of said components is respectively: rhEGF0.0001 ~ 0.001%, olive oil 0.2 ~ 0.8%, artemia extract 0.35 ~ 1%, Rhizoma Phragmitis water extract 0.20 ~ 0.6%.
3. whitening and speckle dispelling skin care item according to claim 2, is characterized in that: the weight content of each component is respectively: rhEGF0.005%, olive oil 0.4%, artemia extract 0.6% and Rhizoma Phragmitis water extract 0.4%.
4. the whitening and speckle dispelling skin care item according to any one of claims 1 to 3, is characterized in that: it is whitening and speckle dispelling cream or whitening and speckle dispelling emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510725022.9A CN105193694A (en) | 2015-10-29 | 2015-10-29 | Skin care product with whitening and freckle-removing functions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510725022.9A CN105193694A (en) | 2015-10-29 | 2015-10-29 | Skin care product with whitening and freckle-removing functions |
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| CN105193694A true CN105193694A (en) | 2015-12-30 |
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| CN201510725022.9A Pending CN105193694A (en) | 2015-10-29 | 2015-10-29 | Skin care product with whitening and freckle-removing functions |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468625A (en) * | 2016-06-08 | 2017-12-15 | 浙江润和生物科技有限公司 | A kind of EGF for medical cosmetology imports liquid |
| CN108309917A (en) * | 2018-05-03 | 2018-07-24 | 左雨萌 | Plant extract skin care product and preparation method thereof with effects of wrinkle resistance, whitening and freckle removal |
| CN108904387A (en) * | 2018-08-22 | 2018-11-30 | 广东丸美生物技术股份有限公司 | It is a kind of to fight external source pressure, skin matrix of protection DNA and its preparation method and application |
| CN113440466A (en) * | 2021-05-26 | 2021-09-28 | 广州市万千粉丝化妆品有限公司 | Skin care product containing II-type proteoglycan for promoting skin repair and improving elasticity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101926741A (en) * | 2010-04-02 | 2010-12-29 | 广东雅倩化妆品有限公司 | Skin refinishing essence and skin care product with same |
| CN102406581A (en) * | 2011-11-28 | 2012-04-11 | 天津郁美净集团有限公司 | Skin protecting composite with function of tightening skin |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468625A (en) * | 2016-06-08 | 2017-12-15 | 浙江润和生物科技有限公司 | A kind of EGF for medical cosmetology imports liquid |
| CN108309917A (en) * | 2018-05-03 | 2018-07-24 | 左雨萌 | Plant extract skin care product and preparation method thereof with effects of wrinkle resistance, whitening and freckle removal |
| CN108904387A (en) * | 2018-08-22 | 2018-11-30 | 广东丸美生物技术股份有限公司 | It is a kind of to fight external source pressure, skin matrix of protection DNA and its preparation method and application |
| CN108904387B (en) * | 2018-08-22 | 2022-03-11 | 广东丸美生物技术股份有限公司 | Skin-care matrix capable of resisting exogenous stress and protecting DNA (deoxyribonucleic acid), and preparation method and application thereof |
| CN113440466A (en) * | 2021-05-26 | 2021-09-28 | 广州市万千粉丝化妆品有限公司 | Skin care product containing II-type proteoglycan for promoting skin repair and improving elasticity |
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Application publication date: 20151230 |