CN103554022B - 一种盐酸去甲乌药碱的合成方法 - Google Patents
一种盐酸去甲乌药碱的合成方法 Download PDFInfo
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- CN103554022B CN103554022B CN201310534046.7A CN201310534046A CN103554022B CN 103554022 B CN103554022 B CN 103554022B CN 201310534046 A CN201310534046 A CN 201310534046A CN 103554022 B CN103554022 B CN 103554022B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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CN201310534046.7A CN103554022B (zh) | 2013-10-31 | 2013-10-31 | 一种盐酸去甲乌药碱的合成方法 |
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CN201310534046.7A CN103554022B (zh) | 2013-10-31 | 2013-10-31 | 一种盐酸去甲乌药碱的合成方法 |
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CN103554022A CN103554022A (zh) | 2014-02-05 |
CN103554022B true CN103554022B (zh) | 2015-12-30 |
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CN201310534046.7A Expired - Fee Related CN103554022B (zh) | 2013-10-31 | 2013-10-31 | 一种盐酸去甲乌药碱的合成方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112409257A (zh) * | 2020-11-30 | 2021-02-26 | 天津阿尔塔科技有限公司 | 一种氘标记的去甲乌药碱稳定性同位素化合物的制备方法 |
CN115260094B (zh) * | 2022-06-16 | 2024-04-05 | 珠海润都制药股份有限公司 | 一种新的盐酸去甲乌药碱的合成方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1539823A (zh) * | 2003-10-27 | 2004-10-27 | 中国医学科学院药物研究所 | 新的去甲乌药碱及其药用盐的制备方法 |
US20060030586A1 (en) * | 2004-08-03 | 2006-02-09 | Education Center Of Traditional Chinese Medicine Co. | Method and health food for preventing and/or alleviating psychiatric disorder, and/or for effectuating sedation |
CN1764647A (zh) * | 2003-03-26 | 2006-04-26 | 埃科特莱茵药品有限公司 | 四氢异喹啉基乙酰胺衍生物作为阿立新受体拮抗剂的应用 |
WO2011038169A2 (en) * | 2009-09-24 | 2011-03-31 | Mallinckrodt Inc. | One-pot preparation of hexahydroisoquinolines from amides |
CN103351338A (zh) * | 2013-06-17 | 2013-10-16 | 张家港威胜生物医药有限公司 | 一种盐酸去甲乌药碱的简易制备工艺 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20020082300A (ko) * | 2001-04-20 | 2002-10-31 | 윤혜숙 | 신규 테트라하이드로이소퀴놀린계 거울상 이성질체 화합물및 그의 약학적으로 허용되는 염, 그 제조방법 및 이를포함하는 약학적 조성물 |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1764647A (zh) * | 2003-03-26 | 2006-04-26 | 埃科特莱茵药品有限公司 | 四氢异喹啉基乙酰胺衍生物作为阿立新受体拮抗剂的应用 |
CN1539823A (zh) * | 2003-10-27 | 2004-10-27 | 中国医学科学院药物研究所 | 新的去甲乌药碱及其药用盐的制备方法 |
US20060030586A1 (en) * | 2004-08-03 | 2006-02-09 | Education Center Of Traditional Chinese Medicine Co. | Method and health food for preventing and/or alleviating psychiatric disorder, and/or for effectuating sedation |
WO2011038169A2 (en) * | 2009-09-24 | 2011-03-31 | Mallinckrodt Inc. | One-pot preparation of hexahydroisoquinolines from amides |
CN103351338A (zh) * | 2013-06-17 | 2013-10-16 | 张家港威胜生物医药有限公司 | 一种盐酸去甲乌药碱的简易制备工艺 |
Non-Patent Citations (5)
Title |
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1-苄基-2-( 4-甲磺酰基-1-羟基-苯乙基)-1, 2, 3, 4-四氢异喹啉类化合物的合成及其抗心律失常活性;冉崇昭,等;《中国药物化学杂志》;20070430;第17卷(第2期);第65-71页 * |
Steps Towards a Practical Synthesis of Macrocyclic Bisbenzylisoquinolines;Yusuf M. Al-Hiaria等;《Journal of Heterocyclic Chemistry》;20050630;第42卷;第650页方案4,第654页第4-5段 * |
Synthesis of Tetrahydroisoquinoline Alkaloids via Anodic Cyanation as the Key Step;Fadila Louafi等;《the Journal of Organic Chemistry》;20100721;第75卷;第5721–5724页 * |
去甲乌药碱(附子一号)的合成;黄龙珍,等;《药学学报》;19811231;第16卷(第12期);第931-933页 * |
盐酸去甲乌药碱的新合成法;杨梓剑,等;《中国药物化学杂志》;20071231;第17卷(第6期);第375-402页 * |
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Inventor after: Li Zhiqiang Inventor after: Chu Chenggang Inventor after: He Shijie Inventor after: Wang Shenyong Inventor after: Wang Xiaojun Inventor after: Hu Changchun Inventor before: Li Zhiqiang Inventor before: Chu Chenggang Inventor before: He Shijie Inventor before: Wang Shenyong Inventor before: Wang Xiaojun Inventor before: Hu Juankai |
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