CN103910704B - 一种奈必洛尔的制备方法及其中间体化合物 - Google Patents
一种奈必洛尔的制备方法及其中间体化合物 Download PDFInfo
- Publication number
- CN103910704B CN103910704B CN201310002019.5A CN201310002019A CN103910704B CN 103910704 B CN103910704 B CN 103910704B CN 201310002019 A CN201310002019 A CN 201310002019A CN 103910704 B CN103910704 B CN 103910704B
- Authority
- CN
- China
- Prior art keywords
- compound
- nebivolol
- salt
- acceptable acid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310002019.5A CN103910704B (zh) | 2013-01-05 | 2013-01-05 | 一种奈必洛尔的制备方法及其中间体化合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310002019.5A CN103910704B (zh) | 2013-01-05 | 2013-01-05 | 一种奈必洛尔的制备方法及其中间体化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103910704A CN103910704A (zh) | 2014-07-09 |
CN103910704B true CN103910704B (zh) | 2016-06-22 |
Family
ID=51036754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310002019.5A Active CN103910704B (zh) | 2013-01-05 | 2013-01-05 | 一种奈必洛尔的制备方法及其中间体化合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103910704B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105085499B (zh) * | 2015-08-07 | 2018-09-25 | 上海现代制药海门有限公司 | 盐酸奈必洛尔中间体混合物的结晶分离方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101575298A (zh) * | 2008-12-31 | 2009-11-11 | 上海予利化学科技有限公司 | 一种制备手性医药中间体2-氨基-1-苯乙醇的方法 |
CN102627573B (zh) * | 2012-03-30 | 2013-09-25 | 山东大学 | 5-氨基酮戊酸盐酸盐的合成方法 |
-
2013
- 2013-01-05 CN CN201310002019.5A patent/CN103910704B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101575298A (zh) * | 2008-12-31 | 2009-11-11 | 上海予利化学科技有限公司 | 一种制备手性医药中间体2-氨基-1-苯乙醇的方法 |
CN102627573B (zh) * | 2012-03-30 | 2013-09-25 | 山东大学 | 5-氨基酮戊酸盐酸盐的合成方法 |
Non-Patent Citations (3)
Title |
---|
Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol;S. Chandrasekhar et al.;《Tetrahedron》;20001231;第56卷;第6339-6344页 * |
Zr-Catalyzed Kinetic Resolution of Allylic Ethers and Mo-Catalyzed Chromene Formation in Synthesis. Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol;Charles W. Johannes et al.;《J. Am. Chem. Soc.》;19980806;第120卷(第33期);第8340-8347页 * |
奈必洛尔的不对称合成;余婧等;《有机化学》;20081231;第28卷(第3期);第511-514页 * |
Also Published As
Publication number | Publication date |
---|---|
CN103910704A (zh) | 2014-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103864774B (zh) | 一种鲁拉西酮的制备方法 | |
CN106117144B (zh) | 一种高纯度依达拉奉的合成工艺 | |
CN110028433B (zh) | 一种氘标记多沙普仑及其代谢物的制备方法 | |
WO2009133556A2 (en) | Cisatracurium derivatives, preparation and uses thereof | |
CN103420855A (zh) | 一种反式-4-氨基环己基甲醇盐酸盐及其制备方法 | |
CN109096126B (zh) | 一种氘标记d9-盐酸克伦特罗的合成方法 | |
CN103910704B (zh) | 一种奈必洛尔的制备方法及其中间体化合物 | |
CN102249976B (zh) | 一种光学纯的(-)-黄皮酰胺类化合物的制备方法 | |
EP2669293B1 (en) | Preparation method of rocuronium | |
CN110172028A (zh) | 一种工业化生产妥洛特罗的方法 | |
CN103601645A (zh) | 1-(苯乙基氨基)丙烷-2-醇类化合物或其盐的制备方法 | |
JP5963140B2 (ja) | 不斉脱水縮合剤 | |
CN103601708B (zh) | 一种前列素药物杂质的制备方法 | |
CN102432594B (zh) | 一种药物中间体1-(3-羟甲基吡啶-2-基)-2-苯基-4-甲基哌嗪的制备方法 | |
CN112028887B (zh) | 一种盐酸戊乙奎醚杂质及其制备方法 | |
CN105968156B (zh) | 一种瑞加诺生的α异构体杂质及其制备方法和用途 | |
CN105431409A (zh) | 制备阿福特罗或其盐的方法 | |
CN108314688A (zh) | 一种西他列汀的合成方法 | |
CN108912018B (zh) | 一种用于合成舒必利的关键中间体中杂质化合物的制备方法及其用途 | |
CN102786489A (zh) | 一种5-甲基异噁唑-4-甲酸乙酯的制备方法 | |
CN115232077A (zh) | 一种噁拉戈利钠有关物质及其制备方法 | |
CN107089942B (zh) | 替吉奥杂质bcb的制备方法 | |
CN103980270A (zh) | 一种(r)-3-奎宁醇的制备方法 | |
CN109942442A (zh) | 一种盐酸达泊西汀有关物质i的制备方法 | |
CN114105836B (zh) | 一种乙二醇的衍生化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170914 Address after: 401121 Yubei District Road, Chongqing, No. 2 Co-patentee after: Fu'an Pharmaceutical Group Pharmaceutical Co., Ltd. Chongqing Bosheng Patentee after: Fu'an Pharmaceutical (Group) Limited by Share Ltd Co-patentee after: FUAN PHARMACEUTICAL GROUP QINGYUTANG PHARMACEUTICAL CO., LTD. Address before: Changshou District Chemical Industrial Park of Chongqing City South Road 401254 Co-patentee before: Chongqing Fuan Pharmaceutical (Group) Co., Ltd. Patentee before: Chongqing Fuan Pharmaceutical (Group) Co., Ltd. |
|
TR01 | Transfer of patent right | ||
CP03 | Change of name, title or address |
Address after: 401254 No. 1 Hua Nan Road, chemical industrial park, Changshou District, Chongqing Co-patentee after: Fu'an Pharmaceutical (Group) Limited by Share Ltd Patentee after: Fu'an Pharmaceutical Group Pharmaceutical Co., Ltd. Chongqing Bosheng Co-patentee after: FUAN PHARMACEUTICAL GROUP QINGYUTANG PHARMACEUTICAL CO., LTD. Address before: No. 2, Huang Yang Road, Yubei District, Chongqing Co-patentee before: Fu'an Pharmaceutical Group Pharmaceutical Co., Ltd. Chongqing Bosheng Patentee before: Fu'an Pharmaceutical (Group) Limited by Share Ltd Co-patentee before: FUAN PHARMACEUTICAL GROUP QINGYUTANG PHARMACEUTICAL CO., LTD. |
|
CP03 | Change of name, title or address |