CN105687656A - Pharmaceutical composition for treating myelitis and preparation method thereof - Google Patents
Pharmaceutical composition for treating myelitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating myelitis and a preparation method thereof. The pharmaceutical composition for treating the myelitis is characterized by being prepared from, by weight, 6-9 parts of radix scutellariae, 6-9 parts of kudzuvine roots, 6-9 parts of indigo naturalis, 6-9 parts of white mulberry root-bark, 6-9 parts of rhizoma atractylodis, 4-6 parts of herb of spanishneedles, 6-9 parts of vines of multiflower knotweed, 6-9 parts of common clubmoss herb, 2-4 parts of panax notoginseng, 6-9 parts of sargentgloryvine stems, 2-4 parts of resina liquidamberis, 4-6 parts of cloves, 6-9 parts of radix achyranthis bidentatae, 6-9 parts of fructus psoraleae, 2-4 parts of rhizoma anemarrhenae, 6-9 parts of rhizoma smilacis glabrae and 6-9 parts of licorice roots. The pharmaceutical composition for treating the myelitis and the preparation method thereof have the advantages that the effective ingredients of traditional Chinese medicine are extracted, the functions of sensory nerves and motor nerves are restored, and the effects of clearing heat, removing acute communicable diseases, promoting blood and qi circulation, dispelling the wind and dampness and relieving spasm and pain are achieved.
Description
The field of inventionthe invention relate to one and treat myelitic pharmaceutical composition and manufacture method。
Background technology
Primary disease is caused by diseases caused by exogenous pathogenic factor seasonal pathogen, again to experience the evil poison of warm。Infect or toxin is invaded and disease caused by spinal cord。Because the pathological changes at spinal cord is often transverse, therefore also known as transverse myelitis。Acute myelitis caused by viral infection mostly occurs person between twenty and fifty, and asexuality difference is dispersed in morbidity, and onset is more anxious。There is slight prodrome, such as the symptom of low grade fever, general malaise or upper respiratory tract infection more。Myelitis refers to by the biological pathogenic infection such as virus, antibacterial, spirillum, rickettsia, parasite, protozoon, mycoplasma, or by infect caused gray nucleus or (with) inflammatory lesion of white matter, with the following quadriplegia of lesion levels, sensory disturbance and vegetative nerve functional disturbance for its Clinical symptoms。Suffer from cold, overwork, wound etc. is often for predisposing factors。The hurried generation of cord symptom, mostly is double; two myelitis。The backache of the numbness of lower limb and tingling, pathological changes corresponding site。Lesion segment, around the zonaesthesia of body, advanced to peak in 2~3 days, the following quadriplegia of lesion levels, anesthesia and disturbance of sphincter。If onset urgency and pathological changes are extensively serious, then paralysis limb muscular tension is low, and tendon reflex disappears, and is for spinal shock。General shock stage is about 2~4 weeks。Syndrome Types of TCM, common evil Yu Feiwei, damp and hot interior Sheng。Current conventional Hormone, antibiotic medicine, symptomatic treatment。The side effect of hormone is big, and patient body is unfavorable。
Summary of the invention
The invention has the beneficial effects as follows: by extracting Effective Component of Chinese Medicine, recover sensation, motorial function, play heat clearing away except pestilence, blood-activating and qi-promoting, damp eliminating of dispeling the wind, relieving spasm to stop pain effect。
The scheme that the present invention adopts for solving above-mentioned technical problem is: one treats myelitic pharmaceutical composition, few side effects, good effect, and the one that absorbance is high treats myelitic pharmaceutical composition。
Chinese medicine one of the present invention treats myelitic pharmaceutical composition, it is characterized in that being made up of the parts by weight of following crude drug: Radix Scutellariae 6~9 parts, Radix Puerariae 6~9 parts, Indigo Naturalis 6~9 parts, Cortex Mori 6~9 parts, Rhizoma Atractylodis 6~9 parts, Herba Bidentis Bipinnatae 4~6 parts, Caulis Polygoni Multiflori 6~9 parts, Herba Lycopodii 6~9 parts, Radix Notoginseng 2~4 parts, Caulis Sargentodoxae 6~9 parts, Resina Liquidambaris 2~4 parts, Flos Caryophylli 4~6 parts, Radix Achyranthis Bidentatae 6~9 parts, Fructus Psoraleae 6~9 parts, the Rhizoma Anemarrhenae 2~4 parts, Rhizoma Smilacis Glabrae 6~9 parts, 6~9 parts of Radix Glycyrrhizae。
Preparation method: first by Resina Liquidambaris, Flos Caryophylli extract volatile oil standby;By Radix Notoginseng (wrapping up with cotton) vapor distillation, collect distillate standby;Again the multi-function extractor of 8 times of 65% alcoholic solution of above-mentioned raw materials medicine addition is heated to reflux 1 hour, filtrate, filters, reclaim ethanol to the greatest extent;Above-mentioned residue is added decocting 3 times, and each 1 hour, 3 times filtrate merged, and filters, then filtrate is merged with above-mentioned volatilization liquid, distillate, alcohol extract, adds dextrin by 1: 1 and stir evenly, be concentrated into the extractum that relative density is 1.08-1.15 (60 DEG C), to obtain final product。
Effect of Chinese medicine of the present invention: Radix Scutellariae this product is the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi。Containing baicalin (C21H18O11) nature and flavor with return footpath: bitter, cold。Return lung, gallbladder, spleen, large intestine, small intestine meridian。Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive。Radix Puerariae this product containing puerarin (C21H20O9), function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash。Indigo Naturalis nature and flavor with return through: salty, cold。Return Liver Channel。Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion。For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared。Cortex Mori nature and flavor with return through: sweet, cold。Return lung meridian。Function with cure mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema。For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema。Cortex Acanthopancis acrid in the mouth, hardship, warm in nature。Return liver, kidney channel。Effect: expelling wind and removing dampness, liver and kidney tonifying, bone and muscle strengthening, inducing diuresis to remove edema。For Bi condition, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi。Herba Bidentis Bipinnatae bitter in the mouth, cold nature。Return lung, the heart, stomach warp。Effect: heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and detumescence。Rhizoma Corydalis Decumbentis is bitter, micro-pungent, temperature。Return Liver Channel。Effect: promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness。For apoplectic hemiplegia, headache, injury from falling down, rheumatic arthralgia, lumbago and skelalgia。Caulis Polygoni Multiflori sweet in the mouth, property is put down。GUIXIN, Liver Channel。Function with cure mainly: nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral。For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia;External treatment skin pruritus。" Bencao Congxin ": " invigorating middle warmer gas, network of passing through, promoting blood circulation, control impairment caused by overstrain。" modern study, the dry rattan having sedative-hypnotic effect, Caulis Polygoni Multiflori this product to be polygonum multiflorum thunb PolygonummultiflorumThunb.。Nature and flavor with return through: sweet, flat。GUIXIN, Liver Channel。Function with cure mainly: nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral。For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia;Herba Lycopodii this product is the dry herb of lycopsid Lycopodium clavatum LycopodiumjaponicumThunb.。Nature and flavor with return through: micro-hardship, pungent, temperature。Return liver,spleen,kidney warp。Function with cure mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral。For joint aches, joint stuffiness。Radix Notoginseng is containing ginsenoside Rb (C54H92O23) and ginsenoside Rg (C42H72O14)。Nature and flavor with return through hardship sweet, micro-, temperature。Return liver, stomach warp。Function with cure mainly: dissipating blood stasis stop blooding, subduing swelling and relieving pain。For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling。Caulis Sargentodoxae this product is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae Sargentodoxacuneata (Oliv.) Rehd.etWils.。Nature and flavor with return through: bitter, flat。Return large intestine, Liver Channel。Function with cure mainly: heat-clearing and toxic substances removing, invigorate blood circulation, dispel the wind。Flos Caryophylli this product containing eugenol (C10H12O2), function with cure mainly: analgesia, anticorrosion。For dental caries。Resina Liquidambaris promoting blood circulation and stopping pain, removing toxic substances and promoting granulation, cooling blood for hemostasis;Radix Achyranthis Bidentatae promoting blood circulation to remove obstruction in the collateral, priming is descending, invigorating the liver and kidney, bone and muscle strengthening;Rhizoma Smilacis Glabrae damp eliminating。Calculus Bovis this product is the bovid cattle BostaurusdomesticusGmelin cholelithiasis dried。This product is pressed dry product and is calculated, containing bilirubin 3H36N4O6)。Nature and flavor with return through: sweet, cool。GUIXIN, Liver Channel。Function with cure mainly: clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances。Fructus Psoraleae this product is the dry mature fruit of legumes psoraleae PsoraleacorylifoliaL.。Nature and flavor with return through: pungent, bitter, temperature。Return kidney, spleen channel。Function with cure mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal。For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea。Rhizoma Smilacis Glabrae this product is the dry rhizome of liliaceous plant smilacis glabra SmilaxglabraRoxb.。Nature and flavor with return footpath: sweet, light, flat。Return liver, stomach warp。Function with cure mainly: dehumidifying, removing toxic substances, easing joint movement。Radix Glycyrrhizae this product is the dry root and rhizome of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL.。Nature and flavor with return through: sweet, flat。GUIXIN, lung, spleen, stomach warp。Function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。Above medicine matches, and brings out the best in each other。
Detailed description of the invention:
Embodiment 1: one treats myelitic pharmaceutical composition, is characterized in that being made up of the parts by weight of following crude drug: Radix Scutellariae 6~9 parts, Radix Puerariae 6~9 parts, Indigo Naturalis 6~9 parts, Cortex Mori 6~9 parts, Rhizoma Atractylodis 6~9 parts, Herba Bidentis Bipinnatae 4~6 parts, Caulis Polygoni Multiflori 6~9 parts, Herba Lycopodii 6~9 parts, Radix Notoginseng 2~4 parts, Caulis Sargentodoxae 6~9 parts, Resina Liquidambaris 2~4 parts, Flos Caryophylli 4~6 parts, Radix Achyranthis Bidentatae 6~9 parts, Fructus Psoraleae 6~9 parts, the Rhizoma Anemarrhenae 2~4 parts, Rhizoma Smilacis Glabrae 6~9 parts, 6~9 parts of Radix Glycyrrhizae。Manufacture method is with above-mentioned。
Embodiment 2: one treats myelitic pharmaceutical composition, is characterized in that being made up of the parts by weight of following crude drug: Radix Scutellariae 9 parts, Radix Puerariae 6 parts, Indigo Naturalis 4 parts, Cortex Mori 9 parts, Rhizoma Atractylodis 6 parts, Herba Bidentis Bipinnatae 4 parts, Caulis Polygoni Multiflori 9 parts, Herba Lycopodii 9 parts, Radix Notoginseng 2 parts, Caulis Sargentodoxae 9 parts, Resina Liquidambaris 2 parts, Flos Caryophylli 6 parts, Radix Achyranthis Bidentatae 9 parts, Fructus Psoraleae 6 parts, the Rhizoma Anemarrhenae 4 parts, Rhizoma Smilacis Glabrae 9 parts, 6 parts of Radix Glycyrrhizae。Manufacture method, with embodiment 1, obtains unguentum。Subpackage every bag 10g。
One. case selection: the present invention treats 52 example patients and all makes a definite diagnosis through hospital above county level, wherein male 34 examples, female 18 example, age 16-45 year, 31.6 years old mean age;The course of disease is 1-15 days, average 5.81 days。
Two. diagnostic criteria: myelitic clinical symptoms can according to the difference of its diseased region, scope, and difference to some extent。Owing to breast myelomere section is longer, and some sections blood supply is poor, and pathological changes Chang Yi involves breast marrow。Its onset symptoms Chang Weishuan numbness of lower limbs, unable, pathological changes corresponding site backache, zonesthesia, or see dysuria。After 2~3 days, to peak, there is the completeness paralysis of below lesion levels, anesthesia, hypohidrosis or lossless network two just retention in PD。Sign: lesions visible transverse spinal cord lesion below horizontal。Completeness paralysis motorica, deep, superficial sensibility disappearance, hypohidrosis or lossless and sphincter dysfunction occur。Shock stage quadriplegia is flaccid paralysis, and muscular tension is low, and tendon reflex is low or disappears, and pathology is levied feminine gender, abdominal reflex and cremasteric reflex and disappeared;Convalescent period hypermyotonia, tendon hyperreflexia, pathology levies the positive。Lab testing: blood: leukocyte counts normally or slightly increases。Cerebrospinal fluid: cerebrospinal pressure is not high。Visible leukocyte in cerebrospinal fluid。Protein content normally or slightly increases。Sugar and chloride content are normal。Generally block phenomenon without canalis spinalis。Substantially can there is spinal cavity partial outlet obstruction because pathological changes position water is swollen in single cases。
Three. criterion of therapeutical effect: effective: symptom and sign disappear;Effective: symptom and sign are obviously improved。Invalid: before and after treatment, symptom and sign is without improvement。
Four. Therapeutic Method: take extractum every day early, evening twice, each 10g, 10th is a course for the treatment of。
Five. therapeutic outcome: the present invention treats 52 example patients, wherein cure 42 examples and account for 80.76%;8 examples that take a turn for the better account for 15.38%;Invalid 2 examples, account for 3.8%;Total effective rate 96.15%, inefficiency 3.84%。
Six. model case:
1. single XX, female, 25 years old。In June, 2012 goes to a doctor。The double; two numbness of lower limbs of main suit, unable, pathological changes corresponding site backache, zonesthesia, through my institute's hospitalization poor effect。Have a medical check-up: transverse spinal cord lesion below lesion levels。Paraesthesia, hypohidrosis or lossless and sphincter dysfunction。Hormone, antibiotic therapy, poor effect is given at local hospital。Lab testing: protein content slightly increases。Patient requests is with treatment by Chinese herbs 2 of the present invention course for the treatment of, and clinical symptoms is wholly absent, and continues to strengthen for 1 course for the treatment of。Follow up a case by regular visits to half a year without recurrence。
2. clump XX, man, 19 years old。In JIUYUE, 2014 is gone to a doctor。The double; two numbness of lower limbs of main suit, unable, backache, zonesthesia, through my institute's hospitalization poor effect。Not good through local hospital therapeutic effect。Magnetic resonance examination: prompting spondylitis。Patient requests is with Drug therapy 3 of the present invention course for the treatment of, and clinical symptoms is wholly absent, and follows up a case by regular visits to half a year without recurrence。
3. an XX, female, 32 years old。In February, 2015 goes to a doctor。The double; two numbness of lower limbs of main suit, unable, pathological changes corresponding site backache, zonesthesia, it is in hospital main symptomatic treatment poor effect through my institute。Have a medical check-up: abdominal reflex disappear and Babinski levies the positive。Magnetic resonance examination: prompting spondylitis。Patient requests is with treatment by Chinese herbs 2 of the present invention course for the treatment of, and clinical symptoms is wholly absent, and continues to strengthen for 1 course for the treatment of。Follow up a case by regular visits to half a year without recurrence。
Claims (2)
1. treat a myelitic pharmaceutical composition, it is characterized in that being made up of the parts by weight of following crude drug: Radix Scutellariae 6~9 parts, Radix Puerariae 6~9 parts, Indigo Naturalis 6~9 parts, Cortex Mori 6~9 parts, Rhizoma Atractylodis 6~9 parts, Herba Bidentis Bipinnatae 4~6 parts, Caulis Polygoni Multiflori 6~9 parts, Herba Lycopodii 6~9 parts, Radix Notoginseng 2~4 parts, Caulis Sargentodoxae 6~9 parts, Resina Liquidambaris 2~4 parts, Flos Caryophylli 6~9 parts, Radix Achyranthis Bidentatae 6~9 parts, Fructus Psoraleae 6~9 parts, the Rhizoma Anemarrhenae 2~4 parts, Rhizoma Smilacis Glabrae 6~9 parts, 6~9 parts of Radix Glycyrrhizae。
2. according to claim 1 preparation method treating myelitic pharmaceutical composition, it is characterized in that first by Resina Liquidambaris, Flos Caryophylli extract volatile oil standby;By Radix Notoginseng (wrapping up with cotton) vapor distillation, collect distillate standby;Again the multi-function extractor of 8 times of 65% alcoholic solution of above-mentioned raw materials medicine addition is heated to reflux 1 hour, filtrate, filters, reclaim ethanol to the greatest extent;Above-mentioned residue is added decocting 3 times, and each 1 hour, 3 times filtrate merged, and filters, then filtrate is merged with above-mentioned volatilization liquid, distillate, alcohol extract, adds dextrin by 1: 1 and stir evenly, be concentrated into the extractum that relative density is 1.08-1.15 (60 DEG C), to obtain final product。
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CN106138712A (en) * | 2016-08-13 | 2016-11-23 | 包莉丽 | One is used for treating myelitic medicine |
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CN106138712A (en) * | 2016-08-13 | 2016-11-23 | 包莉丽 | One is used for treating myelitic medicine |
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