CN103476801A - 用于药物递送的纤维素基纳米粒子 - Google Patents
用于药物递送的纤维素基纳米粒子 Download PDFInfo
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- C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
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Abstract
Description
组分 | MW(g/mol) | DSa | wt%a | wt%b |
DTX | 807.8 | 20.5+/-2.0 | 36.9+/-2.6 | 30 |
PEG | 2000 | 1.0+/-0.3 | 4.7+/-1.5 | - |
溶液 | 尺寸(nm) | PDI |
PBS | 134.0+/-3.4 | 0.1+/-0.08 |
盐水(0.9%) | 125.1+/-2.5 | 0.05+/-0.01 |
蔗糖(10%) | 128.5+/-3.2 | 0.10+/-0.04 |
细胞系 | IC50 DTX(nM) | IC50 DTX(nM)节律性 | IC50 Cellax(nM) |
EMT-6(乳腺) | 80+/-3 | 6+/-2.6 | 9+/-3 |
LL/2(肺) | 767+/-10 | 12+/-4 | 19+/-3 |
血清学参数 | 单位 | 对照物 | Cellax |
总蛋白 | g/L | 50+/-9 | 54+/-3 |
白蛋白 | g/L | 36+/-4 | 39+/-2 |
球蛋白 | g/L | 14+/-5 | 16+/-1 |
A/G比 | 3+/-1 | 3+/-0 | |
胆红素 | μmol/L | 1.5+/-0.5 | 2+/-0.4 |
ALP | lU/L | 134+/-33 | 158+/-9 |
ALT | lU/L | 73+/-53 | 56+/-4 |
AST | lU/L | 267+/-218 | 252+/-74 |
脲 | mmol/L | 9+/-2 | 9+/-1 |
肌酸酐 | μmol/L | 13+/-1 | 19+/-3 |
血液学参数 | 描述 | 对照物 | Cellax |
RBC(×1012/L) | 红血细胞 | 9+/-3 | 11.8+/-0.03 |
Hgb(g/L) | 血色素 | 140+/-28.3 | 161+/-0 |
HCT(L/L) | 血细胞比容 | 0.5+/-0.1 | 0.63+/-0.01 |
MCV(fL) | 平均红血球容积 | 57.9+/-6.9 | 52.9+/-0.49 |
MCH(pg/细胞) | 平均红细胞血红蛋白量 | 15.9+/-2.4 | 13.6+/-0 |
MCHC(g/L) | 平均红细胞血红蛋白量浓度 | 275.5+/-9.2 | 257+/-2.8 |
PLT(×109/L) | 血小板 | 776+/-343.7 | 629.5+/-55.6 |
WBC(×109/L) | 白细胞 | 5.5+/-4.8 | 8.2+/-0.8 |
MPV(fL) | 平均血小板容积 | 5.7+/-1.5 | 4.6+/-0.1 |
RDW% | 红细胞分布 | 18+/-0 | 19.3+/-0.1 |
NE(×109/L) | 嗜中性粒细胞 | 1+/-0.5 | 1.2+/-0.2 |
LY(×109/L) | 淋巴细胞 | 4.2+/-4.2 | 6.6+/-0.4 |
MO(×109/L) | 单核细胞 | 0.3+/-0.1 | 0.3+/-0.1 |
BA(×109/L) | 嗜碱性细胞 | 0+/-0 | 0.01+/-0.01 |
EO(×109/L) | 嗜酸性细胞 | 0.1+/-0 | 0.03+/-0.02 |
Claims (45)
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US201161438842P | 2011-02-02 | 2011-02-02 | |
US61/438,842 | 2011-02-02 | ||
PCT/CA2012/000082 WO2012103634A1 (en) | 2011-02-02 | 2012-02-01 | Cellulose-based nanoparticles for drug delivery |
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US (2) | US8591877B2 (zh) |
EP (1) | EP2670780B1 (zh) |
JP (1) | JP5918274B2 (zh) |
CN (1) | CN103476801B (zh) |
CA (1) | CA2825926A1 (zh) |
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CN110800755A (zh) * | 2019-11-21 | 2020-02-18 | 中国农业科学院农业环境与可持续发展研究所 | 阿维菌素纳米农药制剂及其制备方法 |
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US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
WO2014015422A1 (en) * | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
JP6172507B2 (ja) * | 2013-05-15 | 2017-08-02 | 川研ファインケミカル株式会社 | アシルカルボキシメチルセルロース、及びアシルカルボキシメチルセルロースを含有する化粧料 |
US20160158383A1 (en) * | 2013-07-26 | 2016-06-09 | The University Of British Columbia | Method and device for manufacturing polymer particles containing a therapeutic material |
WO2016037274A1 (en) * | 2014-09-09 | 2016-03-17 | Ontario Institute For Cancer Research (Oicr) | Cellulose-based nanoparticles for drug delivery |
GB2538717B (en) * | 2015-05-26 | 2018-01-31 | Siemens Medical Solutions Usa Inc | Method for reducing variability of representations of regions of interest on reconstructions of medical imaging data |
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- 2012-02-01 CA CA2825926A patent/CA2825926A1/en not_active Abandoned
- 2012-02-01 EP EP12742731.8A patent/EP2670780B1/en not_active Not-in-force
- 2012-02-01 WO PCT/CA2012/000082 patent/WO2012103634A1/en active Application Filing
- 2012-02-01 CN CN201280014967.4A patent/CN103476801B/zh active Active
- 2012-02-01 JP JP2013552078A patent/JP5918274B2/ja active Active
- 2012-02-01 US US13/363,822 patent/US8591877B2/en active Active
- 2012-02-01 ES ES12742731.8T patent/ES2547326T3/es active Active
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US20030027787A1 (en) * | 2000-11-10 | 2003-02-06 | Group Lysac Inc./Lysac Group Inc. | Crosslinked polysaccharide, obtained by crosslinking with substituted polyethylene glycol, as superabsorbant |
CN1660073A (zh) * | 2004-12-30 | 2005-08-31 | 中国科学院上海药物研究所 | 一种多烯紫杉醇纳米粒及其制备方法 |
CN101785757A (zh) * | 2009-01-22 | 2010-07-28 | 美迪思生物科技(北京)有限公司 | 一种紫杉醇自乳化制剂及其制备方法和用途 |
CN101829061A (zh) * | 2010-05-14 | 2010-09-15 | 无锡纳生生物科技有限公司 | 一种紫杉醇纳米颗粒组合物及其制备方法 |
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CN110800755A (zh) * | 2019-11-21 | 2020-02-18 | 中国农业科学院农业环境与可持续发展研究所 | 阿维菌素纳米农药制剂及其制备方法 |
CN110800755B (zh) * | 2019-11-21 | 2020-12-29 | 中国农业科学院农业环境与可持续发展研究所 | 阿维菌素纳米农药制剂及其制备方法 |
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EP2670780B1 (en) | 2015-08-19 |
WO2012103634A1 (en) | 2012-08-09 |
CN103476801B (zh) | 2016-06-29 |
JP2014504614A (ja) | 2014-02-24 |
JP5918274B2 (ja) | 2016-05-18 |
EP2670780A4 (en) | 2014-08-06 |
CA2825926A1 (en) | 2012-08-09 |
ES2547326T3 (es) | 2015-10-05 |
US20140079644A1 (en) | 2014-03-20 |
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