CN103432518A - External medicine composition for treating traumatic injuries and arthralgia syndrome and preparation method of external medicine composition - Google Patents
External medicine composition for treating traumatic injuries and arthralgia syndrome and preparation method of external medicine composition Download PDFInfo
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Abstract
The invention discloses external medicine composition for treating traumatic injuries and arthralgia syndrome, which comprises the following components in parts by weight: 100-350 parts of pseudo-ginseng, 68-200 parts of aconite root, 2-15 parts of curcuma zedoary, 2-15 parts of radix angelicae, 1-10 parts of red paeony root, 1-10 parts of rhizoma corydalis and 1-10 parts of safflower. The invention further discloses the preparation methods of ointment, gels, cleaning agent and cream of the external medicine composition. The external medicine composition for treating traumatic injuries and arthralgia syndrome, which is disclosed by the invention, is reasonable in formula, simple in technology, easy to operate, applicable to the treatment of traumatic injuries and arthralgia syndrome and suitable for industrial production, and has the excellent efficacy of promoting blood circulation to remove blood stasis, relieving swelling and pain, and removing blood stasis for promoting tissue regeneration.
Description
Technical field
The present invention relates to a kind of externally-applied medicinal composition for the treatment of traumatic injury, arthromyodynia and preparation method thereof.
Background technology
Traumatic injury mainly comprises and causes the wound phenomenons such as the pain, swelling, muscle and tendon injury of part or whole body, hemorrhage, cyanosis of the skin due to wound and athletic injury etc., also comprises while breathing the visceral injuries such as inner twinge.Acute traumatic injury, there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more, also comprises some visceral injuries, and processing means commonly used comprise: the medicine for external use Drug therapy, utilize ointment, patch, gel etc., manual reduction, operative treatment, physical therapy etc. more.
Rheumatism be motherland's medical science to human limb, joint, muscle occur that acid is swollen, the general name of the symptoms such as numbness and pain, also referred to as arthromyodynia, can dialectically be wind, cold, wet, pyretic arthralgia.Rheumatism is a kind of destructive autoimmune disease, and the course of disease is stupid for a long time, and severe patient can be disabled.Medicine commonly used has NSAID (non-steroidal anti-inflammatory drug), immunosuppressant, hormones etc., as ibuprofen, diclofenac sodium, celecoxib, azathioprine, prednisone etc., but the untoward reaction of these chemical drugss is numerous, GI irritation as NSAID (non-steroidal anti-inflammatory drug), the secondary infection that immunosuppressant and hormone medicine cause, osteoporosis etc., make these medicines can only be for the short-term relief of symptoms, prolonged application be restricted.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of traumatic injury, arthromyodynia, add and subtract formula according to traditional Chinese medicine theory, there is good promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, promoting tissue regeneration by removing blood stasis effect.Pharmaceutical composition provided by the invention is Chinese medicine for external application,, containing hormone, does not produce drug resistance.The efficacy of a drug affected part of going directly, onset is rapid, is difficult for recurrence, and prescription is original, safe.
Treatment traumatic injury provided by the invention, arthromyodynia externally-applied medicinal composition, the composition that contains following parts by weight:
Radix Notoginseng 100～350;
Radix Aconiti 68～200;
Rhizoma Curcumae 2～15;
The Radix Angelicae Dahuricae 2～15;
Radix Paeoniae Rubra 1～10;
Rhizoma Corydalis 1～10;
Flos Carthami 1～10.
As optimal technical scheme, above-mentioned treatment traumatic injury, arthromyodynia externally-applied medicinal composition, the composition that contains following parts by weight:
Radix Notoginseng 120～300;
Radix Aconiti 80～180;
Rhizoma Curcumae 2～10;
The Radix Angelicae Dahuricae 2～10;
Radix Paeoniae Rubra 2～8;
Rhizoma Corydalis 2～8;
Flos Carthami 2～8.
As optimal technical scheme, above-mentioned treatment traumatic injury, arthromyodynia externally-applied medicinal composition be ointment, also contain the composition of following parts by weight:
Vaseline 340～700;
Dimethyl sulfoxine 8～28;
Lanoline 40～70.
As optimal technical scheme, above-mentioned treatment traumatic injury, arthromyodynia externally-applied medicinal composition be gel, also contain the composition of following parts by weight:
Poly-Pyrusussuriensis fat-80 5～8;
Glycerol 450～550;
Gel-type vehicle 3～5;
Antiseptic 2～4;
Percutaneous absorption enhancer 2～4.
As optimal technical scheme, above-mentioned treatment traumatic injury, arthromyodynia externally-applied medicinal composition be irrigation, also contain the composition of following parts by weight:
Glycerol 280～380
Distilled water 220～320.
As optimal technical scheme, above-mentioned treatment traumatic injury, arthromyodynia externally-applied medicinal composition be cream, also contain the composition of following parts by weight:
Vaseline 280～380;
Glycerol 200～300;
Hexadecanol 3～7;
Liquid paraffin 30～60;
Cutaneous permeable agent 1～3;
Emulsifying agent 2～6.
The invention provides above-mentioned treatment traumatic injury, arthromyodynia the preparation method of externally-applied medicinal composition ointment, comprise the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir.Fill, obtain.
The invention provides above-mentioned treatment traumatic injury, arthromyodynia the preparation method of externally-applied medicinal composition gel, comprise the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, get distilled water, add poly-Pyrusussuriensis fat-80, the glycerol of described amount, stir evenly, add carbomer-980, place, treat that it expands naturally, obtain carbomer-980 solution; The aqueous solution that step e is obtained evenly adds in clear gel and stirs evenly, and obtains drug gel; Get again ethyl hydroxybenzoate, laurocapram that step D obtains medicated powder and described amount, add 3 times of its weight amount dissolve with ethanols, obtain ethanol, under constantly stirring, ethanol is added to drug gel, stir; Separately get 1molL
-1sodium hydroxide solution joins above-mentioned gel under constantly stirring, and regulates pH value to 6.0～7.0, and adding distil water, to full dose, obtains clear gel; Get product.
The invention provides above-mentioned treatment traumatic injury, arthromyodynia the preparation method of externally-applied medicinal composition irrigation, it is characterized in that, comprise the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, step D and step e gained are evenly mixed, add glycerol and distilled water, making ethanol content is 50%, and glycerol content is 20%, fully stirs and gets final product.
The invention provides above-mentioned treatment traumatic injury, arthromyodynia the preparation method of externally-applied medicinal composition cream, comprise the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, the hexadecanol of getting described amount, liquid paraffin, vaseline, azone are put in beaker, and in water-bath, heating is dissolved, and 80 ℃ of insulations, add gained under the D step, and this is oil phase; Get step B, C gained medicated powder is placed in beaker, adds distilled water, adds dodecyl sodium sulfate, glycerol after stirring again, and evenly, is heated to 80 ℃ in water-bath, and steps A gained Radix Notoginseng total arasaponins aqueous solution is mixed with it, obtains, this is water; Above-mentioned oil phase is slowly added in water, constantly be stirred to condensation, treat that temperature is down to below 60 ℃, get product.
In the present invention, the drug effect component analysis is as follows:
Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.There is the dissipating blood stasis hemostasis, subduing swelling and relieving pain.For spitting of blood, to spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, the breast abdomen twinges, tumbling and swelling.
(life) Radix Aconiti: hot, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.There is expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain and narcotic analgesic.
Rhizoma Curcumae: hot, bitter, temperature.Return liver, spleen channel.There is the circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
The Radix Angelicae Dahuricae: suffering, temperature.Return stomach, large intestine, lung meridian.There is the cold expelling of inducing sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, eyebrow shuttle osteodynia, the nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.
Radix Paeoniae Rubra: hardship is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, eliminating stasis to stop pain.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, mass in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Rhizoma Corydalis: hot, bitter, temperature.Return liver, spleen channel.Have and invigorate blood circulation, circulation of qi promoting, pain relieving.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Flos Carthami: suffering, temperature.GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, injury from falling down, skin infection swells and ache.
The present invention fills a prescription rationally, plays altogether the effect of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, promoting tissue regeneration by removing blood stasis, applicable treatment traumatic injury, arthromyodynia disease.Technique is simple, and easy operating is suitable for suitability for industrialized production.
Medicine of the present invention can also adopt the conventional method of Chinese medicine preparation to be prepared into any conventional external preparation.For example medicine of the present invention is added to needed various conventional adjuvants while preparing different dosage form, as lubricant, antioxidant, absorbent etc. are prepared into any conventional exterior-applied formulation with conventional method of Chinese medicinal, as ointment, gel, oiliness ointment etc.
Usage and dosage: behind clean affected part, every day 3 times, evenly smear affected part.
The present invention compares with existing Technology, has the following advantages and effect:
1, a kind of externally-applied medicinal composition for the treatment of traumatic injury, arthromyodynia provided by the invention.There is the effect of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, promoting tissue regeneration by removing blood stasis, be applicable to traumatic injury, swelling and pain due to blood stasis, rheumatic numbness disease.It has that therapeutic effect is good, curative effect fast, toxicity is extremely low, be easy to carry about with one, easy to use.
2, the invention provides the preparation method of the externally-applied medicinal composition (comprising ointment, gel, irrigation, cream) of above-mentioned treatment traumatic injury, arthromyodynia, method technique is simple, easy operating, is suitable for suitability for industrialized production.
3, the present invention adopts the modern refining extractive technique of Chinese medicine to be prepared the key component in prescription, has obviously improved the absorbance of medicine, and the pharmacological action effect of main effective ingredient is significantly higher than conventional formulation.
4, the present invention fills a prescription rationally.Each drug distribution of filling a prescription is extremely wide, aboundresources.Be comprised of Radix Notoginseng, Radix Aconiti, Rhizoma Curcumae, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami seven flavor common medicines, be all the contained medicine of pharmacopeia, material is cheap and easy to get.
5, dosage form advanced person of the present invention, facilitate the patient to use.This agent is evident in efficacy, effect is rapid, toxicity is extremely low, and easily carries, easy to use.And can not bring the advantage of any inconvenience to the patient when treatment, and the present invention compares with other Therapeutic Method, and it has exempted the Liver and kidney toxicity of oral medicine, the shortcomings such as short absorption difference of holdup time of spray.The present invention is particularly suitable for treating traumatic injury, arthromyodynia disease.
The specific embodiment
Further set forth the present invention below in conjunction with embodiment; but the present invention also not only is confined to following embodiment; should be understood that; staff for the art; under the premise without departing from the principles of the invention; can also make some improvement and modification, these improvement and modification also should be considered as protection scope of the present invention.
Embodiment mono-:
The treatment traumatic injury that the present embodiment provides, the agent of arthromyodynia external Chinese medicine ointment, the composition that contains following parts by weight:
Radix Notoginseng 120
Radix Aconiti 68
Rhizoma Curcumae 2
The Radix Angelicae Dahuricae 0.5
Radix Paeoniae Rubra 2
Rhizoma Corydalis 1
Flos Carthami 1
Vaseline 760
Dimethyl sulfoxine 5
Lanoline 20.
The preparation method of above-mentioned treatment traumatic injury, the agent of arthromyodynia external Chinese medicine ointment, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir.Fill, obtain.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, granularity, related substance.Each experimental result shows, ointment of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that ointment of the present invention is on heat, light, the wet steady quality that affects.
Embodiment bis-:
The treatment traumatic injury that the present embodiment provides, the agent of arthromyodynia external Chinese medicine ointment, the composition that contains following parts by weight:
Radix Notoginseng 150
Radix Aconiti 80
Rhizoma Curcumae 0.8
The Radix Angelicae Dahuricae 5
Radix Paeoniae Rubra 2
Rhizoma Corydalis 2
Flos Carthami 2
Vaseline 707
Dimethyl sulfoxine 5
Lanoline 30.
The preparation method of above-mentioned treatment traumatic injury, the agent of arthromyodynia external Chinese medicine ointment, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir.Fill, obtain.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, granularity, related substance.Each experimental result shows, ointment of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that ointment of the present invention is on heat, light, the wet steady quality that affects.
Embodiment tri-:
The treatment traumatic injury that the present embodiment provides, the agent of arthromyodynia external Chinese medicine ointment, the composition that contains following parts by weight:
Radix Notoginseng 210
Radix Aconiti 130
Rhizoma Curcumae 3
The Radix Angelicae Dahuricae 8
Radix Paeoniae Rubra 5
Rhizoma Corydalis 4
Flos Carthami 5
Vaseline 555
Dimethyl sulfoxine 20
Lanoline 50.
The preparation method of above-mentioned treatment traumatic injury, the agent of arthromyodynia external Chinese medicine ointment, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir.Fill, obtain.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, granularity, related substance.Each experimental result shows, ointment of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that ointment of the present invention is on heat, light, the wet steady quality that affects.
Embodiment tetra-:
The treatment traumatic injury that the present embodiment provides, the agent of arthromyodynia external Chinese medicine ointment, the composition that contains following parts by weight:
Radix Notoginseng 300
Radix Aconiti 170
Rhizoma Curcumae 50
The Radix Angelicae Dahuricae 10
Radix Paeoniae Rubra 10
Rhizoma Corydalis 8
Flos Carthami 8
Vaseline 310
Dimethyl sulfoxine 30
Lanoline 80.
The preparation method of above-mentioned treatment traumatic injury, the agent of arthromyodynia external Chinese medicine ointment, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir.Fill, obtain.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, granularity, related substance.Each experimental result shows, ointment of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that ointment of the present invention is on heat, light, the wet steady quality that affects.
Embodiment five:
The treatment traumatic injury that the present embodiment provides, arthromyodynia external application Chinese medicine gel, the composition that contains following parts by weight:
Radix Notoginseng 220
Radix Aconiti 150
Rhizoma Curcumae 6
The Radix Angelicae Dahuricae 8
Radix Paeoniae Rubra 4
Rhizoma Corydalis 3
Flos Carthami 4
Poly-Pyrusussuriensis fat-80 7.5
Glycerol 546.5
Gel-type vehicle 4
Antiseptic 2
Cutaneous permeable agent 3.
The preparation method of above-mentioned treatment traumatic injury, arthromyodynia external application Chinese medicine gel, in this embodiment, gel-type vehicle is carbomer-980, and antiseptic is ethyl hydroxybenzoate, and Percutaneous absorption enhancer is laurocapram, comprises the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, get distilled water, add poly-Pyrusussuriensis fat-80, the glycerol of described amount, stir evenly, add carbomer-980, place, treat that it expands naturally, obtain carbomer-980 solution; The aqueous solution that step e is obtained evenly adds in clear gel and stirs evenly, and obtains drug gel; Get again ethyl hydroxybenzoate, laurocapram that step D obtains medicated powder and described amount, add 3 times of its weight amount dissolve with ethanols, obtain ethanol, under constantly stirring, ethanol is added to drug gel, stir; Separately get 1molL
-1sodium hydroxide solution joins above-mentioned gel under constantly stirring, and regulates pH value to 6.0 ~ 7.0, and adding distil water, to full dose, obtains clear gel; Get product.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, related substance, granularity.Each experimental result shows, gel of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that gel agent of the present invention is on heat, light, the wet steady quality that affects.
Embodiment six:
The treatment traumatic injury that the present embodiment provides, arthromyodynia external application Chinese medicine irrigation, the composition that contains following parts by weight:
Radix Notoginseng 230
Radix Aconiti 140
Rhizoma Curcumae 7
The Radix Angelicae Dahuricae 7
Radix Paeoniae Rubra 6
Rhizoma Corydalis 5
Flos Carthami 6
Glycerol 308
Distilled water 300.
The preparation method of above-mentioned treatment traumatic injury, arthromyodynia external application Chinese medicine irrigation, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, step D and step e gained are evenly mixed, add glycerol and distilled water, making ethanol content is 50%, and glycerol content is 20%, fully stirs and gets final product.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, content, related substance, dispersibility, microorganism.Each experimental result shows, irrigation of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that irrigation of the present invention is on heat, light, the wet steady quality that affects.
Embodiment seven:
The treatment traumatic injury that the present embodiment provides, arthromyodynia external-application cream, the composition that contains following parts by weight:
Radix Notoginseng 210
Radix Aconiti 110
Rhizoma Curcumae 8
The Radix Angelicae Dahuricae 7
Radix Paeoniae Rubra 5
Rhizoma Corydalis 6
Flos Carthami 7
Vaseline 313
Glycerol 250
Hexadecanol 5
Liquid paraffin 50
Antiseptic 2
Cutaneous permeable agent 5.
The preparation method of above-mentioned treatment traumatic injury, arthromyodynia external-application cream, wherein antiseptic is azone, Percutaneous absorption enhancer is dodecyl sodium sulfate, the steps include:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, the hexadecanol of getting described amount, liquid paraffin, vaseline, azone are put in beaker, and in water-bath, heating is dissolved, and 80 ℃ of insulations, add gained under the D step, and this is oil phase; Get step B, C gained medicated powder is placed in beaker, adds distilled water, adds dodecyl sodium sulfate, glycerol after stirring again, and evenly, is heated to 80 ℃ in water-bath, and steps A gained Radix Notoginseng total arasaponins aqueous solution is mixed with it, obtains, this is water; Above-mentioned oil phase is slowly added in water, constantly be stirred to condensation, treat that temperature is down to below 60 ℃, get product.
By carrying out respectively influence factor's test (comprising: hot test, high humility test, strong illumination test) under 2010 editions two appendix XIXC pharmaceutical preparation stability test guideline items of Chinese Pharmacopoeia, investigate the situation of change of its character, uniformity, content, granularity, related substance, lamination.Each experimental result shows, ointment of the present invention is up to specification, and under influence factor's experimental condition (high temperature, high humidity, illumination), every investigation project is without significant change, shows that ointment of the present invention is on heat, light, the wet steady quality that affects.
Claims (10)
1. an externally-applied medicinal composition for the treatment of traumatic injury, arthromyodynia, is characterized in that, the composition that contains following parts by weight:
Radix Notoginseng 100～350
Radix Aconiti 68～200
Rhizoma Curcumae 2～15
The Radix Angelicae Dahuricae 2～15
Radix Paeoniae Rubra 1～10
Rhizoma Corydalis 1～10
Flos Carthami 1～10.
2. the externally-applied medicinal composition for the treatment of traumatic injury according to claim 1, arthromyodynia, is characterized in that, the composition that contains following parts by weight:
Radix Notoginseng 120～300
Radix Aconiti 80～180
Rhizoma Curcumae 2～10
The Radix Angelicae Dahuricae 2～10
Radix Paeoniae Rubra 2～8
Rhizoma Corydalis 2～8
Flos Carthami 2～8.
3. the externally-applied medicinal composition for the treatment of traumatic injury according to claim 2, arthromyodynia, is characterized in that, described externally-applied medicinal composition is ointment, the composition that contains following parts by weight:
Vaseline 340～700
Dimethyl sulfoxine 8～28
Lanoline 40～70.
4. the externally-applied medicinal composition for the treatment of traumatic injury according to claim 2, arthromyodynia, is characterized in that, described externally-applied medicinal composition is gel, also contains the composition of following parts by weight:
Poly-Pyrusussuriensis fat-80 5～8
Glycerol 450～550
Gel-type vehicle 3～5
Antiseptic 2～4
Cutaneous permeable agent 2～4.
5. the externally-applied medicinal composition for the treatment of traumatic injury according to claim 2, arthromyodynia, is characterized in that, described externally-applied medicinal composition is irrigation, also contains the composition of following parts by weight:
Glycerol 280～380
Distilled water 220～320.
6. the externally-applied medicinal composition for the treatment of traumatic injury according to claim 2, arthromyodynia, is characterized in that, described externally-applied medicinal composition is cream, also contains the composition of following parts by weight:
Vaseline 280～380
Glycerol 200～300
Hexadecanol 3～7
Liquid paraffin 30～60
Cutaneous permeable agent 1～3
Emulsifying agent 2～6.
7. the preparation method of the externally-applied medicinal composition for the treatment of traumatic injury according to claim 3, arthromyodynia, is characterized in that, comprises the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, by vaseline after 80～100 ℃ of temperature controls are dissolved, 115～120 ℃ of sterilizings of temperature control, be cooled to 70～80 ℃ by sterilized vaseline;
G, by lanoline in 115～120 ℃ of sterilizings of temperature control;
H, by 55～65 ℃ of dimethyl sulfoxine temperature controls to dissolving;
I, at first vaseline is put into to material-compound tank, put into a half and stir; Secondly the total volatile oil, dimethyl sulfoxine and the lanoline congruent melting that D are obtained, filter and drop in material-compound tank and stir; Again the E mixed aqueous solution is added to material-compound tank, stir, fill, obtain.
8. the preparation method of the externally-applied medicinal composition for the treatment of traumatic injury according to claim 4, arthromyodynia, is characterized in that, comprises the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, get distilled water, add poly-Pyrusussuriensis fat-80, the glycerol of described amount, stir evenly, add carbomer-980, place, treat that it expands naturally, obtain carbomer-980 solution; The aqueous solution that step e is obtained evenly adds in clear gel and stirs evenly, and obtains drug gel; Get again ethyl hydroxybenzoate, laurocapram that step D obtains medicated powder and described amount, add 3 times of its weight amount dissolve with ethanols, obtain ethanol, under constantly stirring, ethanol is added to drug gel, stir; Separately get 1molL
-1sodium hydroxide solution joins above-mentioned gel under constantly stirring, and regulates pH value to 6.0～7.0, and adding distil water, to full dose, gets product.
9. the preparation method of the externally-applied medicinal composition for the treatment of traumatic injury according to claim 5, arthromyodynia, is characterized in that, comprises the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, Radix Notoginseng, Radix Aconiti, Radix Angelicae Dahuricae extract are added to 70 ℃ of dissolvings of appropriate distilled water, obtain mixed aqueous solution;
F, step D and step e gained are evenly mixed, add glycerol and distilled water, get product.
10. the preparation method of the externally-applied medicinal composition for the treatment of traumatic injury according to claim 6, arthromyodynia, is characterized in that, comprises the steps:
A, employing ethanol extract from water precipitation are extracted Radix Notoginseng, obtain Radix Notoginseng extract;
B, employing cholamine cold-maceration are extracted Radix Aconiti, obtain the Radix Aconiti extract;
C, employing heating reflux method are extracted the Radix Angelicae Dahuricae, obtain Radix Angelicae Dahuricae extract;
D, employing steam distillation are extracted Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Carthami respectively, obtain volatile oil, and the three mixes in proportion, and obtains total volatile oil;
E, the hexadecanol of getting described amount, liquid paraffin, vaseline, azone are put in beaker, and in water-bath, heating is dissolved, and 80 ℃ of insulations, add gained under the D step, and this is oil phase; Get step B, C gained medicated powder is placed in beaker, adds distilled water, adds dodecyl sodium sulfate, glycerol after stirring again, and evenly, is heated to 80 ℃ in water-bath, and steps A gained Radix Notoginseng total arasaponins aqueous solution is mixed with it, obtains, this is water; Above-mentioned oil phase is slowly added in water, constantly be stirred to condensation, treat that temperature is down to below 60 ℃, get product.
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| CN109106916A (en) * | 2018-10-31 | 2019-01-01 | 成都体育学院 | A kind of Chinese medicine composition and preparation method thereof for treating rheumatic arthritis |
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| CN1748778A (en) * | 2004-09-13 | 2006-03-22 | 孙法智 | Plaster for bone setting and removing stagnation |
| CN101972464A (en) * | 2010-10-29 | 2011-02-16 | 韩世昌 | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof |
| CN102908442A (en) * | 2012-11-14 | 2013-02-06 | 李周良 | Composition for treating traumatic injuries and medicinal liquor thereof |
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| CN1748778A (en) * | 2004-09-13 | 2006-03-22 | 孙法智 | Plaster for bone setting and removing stagnation |
| CN101972464A (en) * | 2010-10-29 | 2011-02-16 | 韩世昌 | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof |
| CN102908442A (en) * | 2012-11-14 | 2013-02-06 | 李周良 | Composition for treating traumatic injuries and medicinal liquor thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107440976A (en) * | 2017-09-23 | 2017-12-08 | 东莞市白天鹅纸业有限公司 | A kind of composition with whitening function and the hygenic towelette containing said composition |
| CN107440976B (en) * | 2017-09-23 | 2021-03-30 | 东莞市白天鹅纸业有限公司 | Composition with whitening function and wet tissue containing composition |
| CN109106916A (en) * | 2018-10-31 | 2019-01-01 | 成都体育学院 | A kind of Chinese medicine composition and preparation method thereof for treating rheumatic arthritis |
| CN109106916B (en) * | 2018-10-31 | 2021-06-11 | 成都体育学院 | A Chinese medicinal composition for treating rheumatic arthritis, and preparation method thereof |
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