CN103690644B - Promote the Chinese medicine preparation of fracture recovering - Google Patents
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Abstract
The invention provides a kind of for promoting the Chinese medicine composition of fracture recovering, it comprises: Rhizoma Drynariae, Caulis Sargentodoxae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Radix Et Caulis Acanthopanacis Senticosi, Lignum Sappan, Folium Et Cacumen Murrayae, Herba Gendarussae, Resina Liquidambaris, Ramulus Sambuci Williamsii, Herba Visci, Caulis Gneti, Radix Achyranthis Bidentatae, Radix Codonopsis, Herba Haleniae Corniculatae, Herba Hyperici Sampsonii, Myrrha, Herba Fici Simplicissimae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae and Caulis Bauhihiae Championii.Adopt this Chinese medicine composition to promote blood circulation promoting and blood stasis dispelling, make QI and blood unobstructed, the stagnant dissipation of the stasis of blood, new bone proliferation, accelerate the healing of fracture.<!-- 2 -->
Description
Technical field
The present invention relates to Chinese medicine technical field, particularly relating to a kind of for promoting the Chinese medicine composition of fracture recovering.
Background technology
Fracture is a kind of commonly encountered diseases clinically, and in sports, vehicle accident and daily life, reel unavoidable, in addition, recent natural disaster such as earthquake, tsunami etc. take place frequently, and make the sickness rate of primary disease increase.Particularly after earthquake, there will be a large amount of fracture patients.According to national health tissue statistics, China has more than 3,000,000 Crinis Carbonisatus bone growth promoting foldings every year.
Conventional treatments after fracturing uses plaster fixing again after being resetted by fracture, relies on the regeneration capacity of skeleton self to make its normal healing; For more serious fracture patient, then need to carry out operative treatment, with draw point and steel plate, fracture is fixed, or with intramedullary needle, or use external fixer.These methods treatment fracture makes the misery of patient increase, and healing time increases, and brings inconvenience to patient.
The final purpose for the treatment of fracture be make injured limbs maximum possible, its motor function of rehabilitation to greatest extent.Therefore.In fractures, it resets, fixing, functional exercise, these four cardinal principles of prevention infection are very important.Be fixedly that treatment fracture is successfully crucial, conventional fixing means has: the internal fixtion such as extenal fixation and surgical incision upper steel plate, draw point, intramedullary needle, screw such as plintlet, plaster bandage, exterior fixation bracket, traction braking are fixing.
Functional exercise after fracture is also very important, and the size of tempering amplitude for this specifically should be treated depending on concrete condition, should be incremental, tempers the healing that can have a strong impact on fracture with advancing rashly, even occurs to be shifted again, should be fully recognized that this point.
Chinese medicine is applied in fractures often out in the cold.Fracture site is due to the damage of skeleton and surrounding tissue, and the tissue injury of internal fixtion, often causes hematoma.So just have impact on the blood circulation of local, difficulty is brought to the formation of callus and the reparation of local organization.This phenomenon traditional Chinese medical science thinks it is also the disease of blood stasis, therefore, it is possible to coordinate the Chinese medicine situation of synthetism of invigorating blood circulation to make a world of difference when treating fracture.
After fracture, blood stasis retardance meridians, internal hemorrhage can not absorb in time, occurs local edema, pain even generates heat.Visible ought to blood circulation promoting and blood stasis dispelling, consider that this is injured in the sinews or bones relevant with Liver and kidney, kidney governing bones, liver lives in.Therefore should blood circulation promoting and blood stasis dispelling be main in treatment, liver and kidney tonifying be auxiliary principle.
The principle of fracture surgery rehabilitation is promoted based on the above-mentioned traditional Chinese medical science, the invention provides a kind of novel Chinese medicine composition, this Chinese medicine composition is based on blood circulation promoting and blood stasis dispelling, and liver and kidney tonifying is auxiliary principle, uses drug effect, promote blood circulation promoting and blood stasis dispelling, make QI and blood unobstructed, the stagnant dissipation of the stasis of blood, new bone proliferation, accelerate the healing of fracture, overcome the various defects that Western medicine promotes to exist in fracture surgery rehabilitation.
Summary of the invention
Technical problem to be solved by this invention is, there is provided a kind of for promoting the Chinese medicine composition of fracture surgery rehabilitation, this Chinese medicine composition is adopted to promote blood circulation promoting and blood stasis dispelling, make QI and blood unobstructed, the stagnant dissipation of the stasis of blood, new bone proliferation, accelerates the rehabilitation of fracture, overcomes the various defects that Western medicine promotes to exist in fracture surgery rehabilitation.
Ask to solve above-mentioned technology, the invention provides a kind of for promoting the Chinese medicine composition of fracture recovering, it comprises: Rhizoma Drynariae, Caulis Sargentodoxae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Radix Et Caulis Acanthopanacis Senticosi, Lignum Sappan, Folium Et Cacumen Murrayae, Herba Gendarussae, Resina Liquidambaris, Ramulus Sambuci Williamsii, Herba Visci, Caulis Gneti, Radix Achyranthis Bidentatae, Radix Codonopsis, Herba Haleniae Corniculatae, Herba Hyperici Sampsonii, Myrrha, Herba Fici Simplicissimae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae and Caulis Bauhihiae Championii.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each component is:
Rhizoma Drynariae 50 weight portion ~ 60 weight portion, Caulis Sargentodoxae 30 weight portion ~ 40 weight portion, Caulis Polygoni Multiflori 65 weight portion ~ 75 weight portion, Cortex Acanthopancis 30 weight portion ~ 40 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Lignum Sappan 20 weight portion ~ 30 weight portion, Folium Et Cacumen Murrayae 30 weight portion ~ 40 weight portion, Herba Gendarussae 25 weight portion ~ 35 weight portion, Resina Liquidambaris 20 weight portion ~ 30 weight portion, Ramulus Sambuci Williamsii 35 weight portion ~ 45 weight portion, Herba Visci 25 weight portion ~ 35 weight portion, Caulis Gneti 30 weight portion ~ 40 weight portion, Radix Achyranthis Bidentatae 40 weight portion ~ 50 weight portion, Radix Codonopsis 50 weight portion ~ 60 weight portion, Herba Haleniae Corniculatae 20 weight portion ~ 30 weight portion, Herba Hyperici Sampsonii 25 weight portion ~ 35 weight portion, Myrrha 35 weight portion ~ 45 weight portion, Herba Fici Simplicissimae 30 weight portion ~ 40 weight portion, Radix Glycyrrhizae 25 weight portion ~ 35 weight portion, Caulis et folium cryptotaeniae japonicae 25 weight portion ~ 35 weight portion and Caulis Bauhihiae Championii 35 weight portion ~ 45 weight portion.
Wherein, in described Chinese medicine composition, the weight fraction ratio of each component is:
Rhizoma Drynariae 53 weight portion ~ 57 weight portion, Caulis Sargentodoxae 33 weight portion ~ 37 weight portion, Caulis Polygoni Multiflori 68 weight portion ~ 72 weight portion, Cortex Acanthopancis 33 weight portion ~ 37 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Lignum Sappan 23 weight portion ~ 27 weight portion, Folium Et Cacumen Murrayae 33 weight portion ~ 37 weight portion, Herba Gendarussae 28 weight portion ~ 32 weight portion, Resina Liquidambaris 23 weight portion ~ 27 weight portion, Ramulus Sambuci Williamsii 38 weight portion ~ 42 weight portion, Herba Visci 28 weight portion ~ 32 weight portion, Caulis Gneti 33 weight portion ~ 37 weight portion, Radix Achyranthis Bidentatae 43 weight portion ~ 47 weight portion, Radix Codonopsis 53 weight portion ~ 57 weight portion, Herba Haleniae Corniculatae 23 weight portion ~ 27 weight portion, Herba Hyperici Sampsonii 28 weight portion ~ 32 weight portion, Myrrha 38 weight portion ~ 42 weight portion, Herba Fici Simplicissimae 33 weight portion ~ 37 weight portion, Radix Glycyrrhizae 28 weight portion ~ 32 weight portion, Caulis et folium cryptotaeniae japonicae 28 weight portion ~ 32 weight portion and Caulis Bauhihiae Championii 38 weight portion ~ 42 weight portion.
Wherein, in described Chinese medicine composition, the weight fraction ratio of each component is:
Rhizoma Drynariae 55 weight portion, Caulis Sargentodoxae 35 weight portion, Caulis Polygoni Multiflori 70 weight portion, Cortex Acanthopancis 35 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Lignum Sappan 25 weight portion, Folium Et Cacumen Murrayae 35 weight portion, Herba Gendarussae 30 weight portion, Resina Liquidambaris 25 weight portion, Ramulus Sambuci Williamsii 40 weight portion, Herba Visci 30 weight portion, Caulis Gneti 35 weight portion, Radix Achyranthis Bidentatae 45 weight portion, Radix Codonopsis 55 weight portion, Herba Haleniae Corniculatae 25 weight portion, Herba Hyperici Sampsonii 30 weight portion, Myrrha 40 weight portion, Herba Fici Simplicissimae 35 weight portion, Radix Glycyrrhizae 30 weight portion, Caulis et folium cryptotaeniae japonicae 30 weight portion and Caulis Bauhihiae Championii 40 weight portion.
Wherein, the dosage form of described Chinese medicine composition is soup decoct and powder.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of this Chinese medicine composition is powder, be specially:
The first step, is mixed in proportion described component, pulverizes and sieves through Universalpulverizer, obtains 100 order ~ 200 object powder;
Second step, is the alcohol reflux 2 times ~ 4 times of 80% ~ 90% by the powder determining alcohol that the first step obtains, filters, merging filtrate, and concentrating under reduced pressure removing ethanol, obtains and get dry extract, and wherein, the amount of the ethanol added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step; the dry cream that second step obtains is put into high energy ball mill; evacuation; pour the argon of 0.1MPa as protective gas; the rotating speed of setting high energy ball mill is 200 revs/min ~ 400 revs/min; ball milling 40 minutes ~ 1 hour, shuts down cooling 20 ~ 30 minutes, obtains the nanometer powder of 100nm ~ 300nm.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when dosage form is soup decoct, be specially:
Described each raw material components is mixed by weight, obtain mixture, add the water relative to mixture quality 3 ~ 5 times, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, filtering residue adds the water relative to 2 ~ 4 times, mixture again, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, mixed the filtrate of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup decoct.
Beneficial effect of the present invention:
Adopt this Chinese medicine composition to promote blood circulation promoting and blood stasis dispelling, make QI and blood unobstructed, the stagnant dissipation of the stasis of blood, new bone proliferation, accelerate the healing of fracture, overcome the various defects that Western medicine promotes to exist in fracture surgery rehabilitation.
Detailed description of the invention
The invention provides a kind of for promoting the Chinese medicine composition of fracture recovering, it comprises: Rhizoma Drynariae, Caulis Sargentodoxae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Radix Et Caulis Acanthopanacis Senticosi, Lignum Sappan, Folium Et Cacumen Murrayae, Herba Gendarussae, Resina Liquidambaris, Ramulus Sambuci Williamsii, Herba Visci, Caulis Gneti, Radix Achyranthis Bidentatae, Radix Codonopsis, Herba Haleniae Corniculatae, Herba Hyperici Sampsonii, Myrrha, Herba Fici Simplicissimae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae and Caulis Bauhihiae Championii.
Further, described Chinese medicine composition is only made up of above-mentioned raw materials medicine.
In described Chinese medicine composition, the parts by weight of each component are:
Rhizoma Drynariae 50 weight portion ~ 60 weight portion, Caulis Sargentodoxae 30 weight portion ~ 40 weight portion, Caulis Polygoni Multiflori 65 weight portion ~ 75 weight portion, Cortex Acanthopancis 30 weight portion ~ 40 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Lignum Sappan 20 weight portion ~ 30 weight portion, Folium Et Cacumen Murrayae 30 weight portion ~ 40 weight portion, Herba Gendarussae 25 weight portion ~ 35 weight portion, Resina Liquidambaris 20 weight portion ~ 30 weight portion, Ramulus Sambuci Williamsii 35 weight portion ~ 45 weight portion, Herba Visci 25 weight portion ~ 35 weight portion, Caulis Gneti 30 weight portion ~ 40 weight portion, Radix Achyranthis Bidentatae 40 weight portion ~ 50 weight portion, Radix Codonopsis 50 weight portion ~ 60 weight portion, Herba Haleniae Corniculatae 20 weight portion ~ 30 weight portion, Herba Hyperici Sampsonii 25 weight portion ~ 35 weight portion, Myrrha 35 weight portion ~ 45 weight portion, Herba Fici Simplicissimae 30 weight portion ~ 40 weight portion, Radix Glycyrrhizae 25 weight portion ~ 35 weight portion, Caulis et folium cryptotaeniae japonicae 25 weight portion ~ 35 weight portion and Caulis Bauhihiae Championii 35 weight portion ~ 45 weight portion.
Further preferably, in described Chinese medicine composition, the parts by weight of each component are:
Rhizoma Drynariae 53 weight portion ~ 57 weight portion, Caulis Sargentodoxae 33 weight portion ~ 37 weight portion, Caulis Polygoni Multiflori 68 weight portion ~ 72 weight portion, Cortex Acanthopancis 33 weight portion ~ 37 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Lignum Sappan 23 weight portion ~ 27 weight portion, Folium Et Cacumen Murrayae 33 weight portion ~ 37 weight portion, Herba Gendarussae 28 weight portion ~ 32 weight portion, Resina Liquidambaris 23 weight portion ~ 27 weight portion, Ramulus Sambuci Williamsii 38 weight portion ~ 42 weight portion, Herba Visci 28 weight portion ~ 32 weight portion, Caulis Gneti 33 weight portion ~ 37 weight portion, Radix Achyranthis Bidentatae 43 weight portion ~ 47 weight portion, Radix Codonopsis 53 weight portion ~ 57 weight portion, Herba Haleniae Corniculatae 23 weight portion ~ 27 weight portion, Herba Hyperici Sampsonii 28 weight portion ~ 32 weight portion, Myrrha 38 weight portion ~ 42 weight portion, Herba Fici Simplicissimae 33 weight portion ~ 37 weight portion, Radix Glycyrrhizae 28 weight portion ~ 32 weight portion, Caulis et folium cryptotaeniae japonicae 28 weight portion ~ 32 weight portion and Caulis Bauhihiae Championii 38 weight portion ~ 42 weight portion.
In described Chinese medicine composition, the weight fraction ratio of each component is:
Rhizoma Drynariae 55 weight portion, Caulis Sargentodoxae 35 weight portion, Caulis Polygoni Multiflori 70 weight portion, Cortex Acanthopancis 35 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Lignum Sappan 25 weight portion, Folium Et Cacumen Murrayae 35 weight portion, Herba Gendarussae 30 weight portion, Resina Liquidambaris 25 weight portion, Ramulus Sambuci Williamsii 40 weight portion, Herba Visci 30 weight portion, Caulis Gneti 35 weight portion, Radix Achyranthis Bidentatae 45 weight portion, Radix Codonopsis 55 weight portion, Herba Haleniae Corniculatae 25 weight portion, Herba Hyperici Sampsonii 30 weight portion, Myrrha 40 weight portion, Herba Fici Simplicissimae 35 weight portion, Radix Glycyrrhizae 30 weight portion, Caulis et folium cryptotaeniae japonicae 30 weight portion and Caulis Bauhihiae Championii 40 weight portion.
In this Chinese medicine composition, each component pharmacology is as follows:
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney, there is wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; To invigorate blood circulation effect of arteries and veins, cure mainly anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination such as to be itched at the card.
Radix Et Caulis Acanthopanacis Senticosi: latin name AcanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body void is frail, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Lignum Sappan: sweet in the mouth, salty, property is put down, and enters the heart, liver, large intestine channel, has blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain, for blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury, the cards such as fracture carbuncle sore tumefacting virus.
Folium Et Cacumen Murrayae: latin name MurrayaeFoliumetCacumen, acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema.
Herba Gendarussae: latin name GendarussaeHerba, acrid in the mouth, bitter, property is put down, and returns liver, kidney, lung meridian, has wind-damp dispelling; Dissipating blood stasis blood; Effect of reuniting the fractured tendons and bones, cures mainly rheumatic arthralgia; Menoxenia; Puerperal abdonimal pain; Treating swelling and pain by traumatic injury; The cards such as fracture.
Resina Liquidambaris: latin name ResinaLiquidambaris, acrid in the mouth, micro-hardship, property is put down, and return lung, spleen channel, have promoting blood circulation and stopping pain, removing toxic substances and promoting granulation, effect of cooling blood for hemostasis, cures mainly traumatic injury, carbuncle pain, spits blood, the cards such as traumatic hemorrhage.
Ramulus Sambuci Williamsii: latin name Sambucuswillaamsii, sweet in the mouth, hardship, property is put down, there is effect of anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, synthetism of stimulating the menstrual flow, cure mainly the cards such as various diseases associated with inflammation, rheumatic arthritis, lumbago and skelalgia, sore swollen toxin pneumonia, appendicitis, acute cellulitis, tumor, traumatic injury, fracture.
Herba Visci: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive effect, for the soreness of waist and knee joint caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, rheumatic arthralgia, articular instability, the cards such as the frequent fetal movement that asthenia of renal qi causes.
Caulis Gneti: bitter in the mouth, slightly warm in nature, has expelling wind and removing dampness, eliminating stasis to stop pain, and effect of preventing phlegm from forming and stopping coughing, cures mainly rheumatic arthralgia, lumbago, treating swelling and pain by traumatic injury, the fracture injury of tendon and muscle, ulcer haemorrhage, chronic tracheitis, the cards such as venom.
Radix Achyranthis Bidentatae: bitter in the mouth, sweet, sour, property is put down, and returns liver, kidney channel, has the cards such as eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, drink blood is descending, cures mainly amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, aphtha, the cards such as haematemesis.
Radix Codonopsis: sweet in the mouth, property is put down, and enters lung, spleen channel, has QI invigorating strengthening the spleen, the symptoms such as the effect of nourishing blood to promote the production of body fluid, is mainly used in the fatigue and weakness of deficiency of both the splenic and pulmonary QI or QI and blood deficiency, breathes hard, cough spontaneous perspiration, spleen reinforcing nourishing the stomach is longer than by Radix Codonopsis, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property put down, spleen invigorating fortune and not dry; Flavour is cloudy and do not wet, and can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes that intestinal is to the absorption of nutrient substance.
Herba Haleniae Corniculatae: sweet in the mouth, hardship, cold in nature, have heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, cures mainly hepatitis, vasculitis, and trauma infection contamination generates heat, the cards such as traumatic hemorrhage.
Herba Hyperici Sampsonii: bitter in the mouth, pungent, cold in nature, return liver, spleen channel, there is removing pathogenic heat from blood and toxic substance from the body, promoting blood flow to regulate menstruation, effect of dispelling wind and removing obstruction in the collateral, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, carbuncle furunculosis, scald, venom, menoxenia, dysmenorrhea, leucorrhea, traumatic injury, rheumatic arthralgia, the cards such as aphtha.
Myrrha: bitter in the mouth, pungent, property is put down, and enters liver, spleen, the heart, kidney channel, has effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cure mainly the cards such as breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Herba Fici Simplicissimae: sweet, tepor, has invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cures mainly pulmonary tuberculosis cough, chronic bronchitis, rheumatic arthritis, lumbago and skelalgia, insufficiency of the spleen edema, after being ill the card such as night sweat.
Radix Glycyrrhizae: latin name GlycyrrhizaeRadixetRhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.
Caulis et folium cryptotaeniae japonicae: acrid in the mouth is bitter; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; Effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, gonorrhea, hernia, acute toothache, and carbuncle furuncle swells, herpes zoster, the cards such as skin pruritus.
Caulis Bauhihiae Championii: bitter in the mouth, pungent, property is put down, and have expelling wind and removing dampness, effect of promoting flow of QI and blood, cures mainly rheumatic arthralgia, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, the cards such as dysentery.
Motherland's medical science is thought: after traumatic injury, all has blood stasis in body.Chinese medicine fumigation and wash method can play alleviation muscular tone, ease the pain, the mechanism of reducing swelling and alleviating pain effect mainly comprises following some (1) warming function by medicine steam, the effect of warm cold expelling heresy, promoting the flow of QI-blood by warming the meridian and unobstructed QI and blood can be played, general rule is muscle not, reach promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain curative effect; (3) suffering limb pore can be made during steam type hot compress to open, capillary network is open, improves local nutrition, heresy in body is gone out, thus cure diseases; After suffering limb blood circulation improves, pain threshold is also improved, and can relaxed muscle, tendon, ligament, tissue, plays prevention muscle spasm and ankylosis effect; (4) warm hydrotherapy can the calm mind, mood placating, improves the patient threshold of pain, reaches except pain object; (5) by changing hemorheological character, alleviate the degree of dense glutinous, the coagulation of blood stasis, add RBV, ensure that the amino acid whose supply of collage synthesis, have activated the activity of fibroblast, osteoblast and chondroblast, promote its synthesis to collagen and the deposition of calcium salt.Chinese medicine fumigation and washing plays the double effects of thermotherapy, medication by above mechanism, thus promotes the healing of fracture.
Therefore, present invention also offers above-mentioned Chinese medicine composition and be combined by mode that is for oral administration and external, dosage form for oral administration is soup decoct, oral medication, and exterior-applied formulation is powder, fumigation treatment.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of this Chinese medicine composition is powder, be specially:
The first step, is mixed in proportion described component, pulverizes and sieves through Universalpulverizer, obtains 100 order ~ 200 object powder;
Second step, is the alcohol reflux 2 times ~ 4 times of 80% ~ 90% by the powder determining alcohol that the first step obtains, filters, merging filtrate, and concentrating under reduced pressure removing ethanol, obtains and get dry extract, and wherein, the amount of the ethanol added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step; the dry cream that second step obtains is put into high energy ball mill; evacuation; pour the argon of 0.1MPa as protective gas; the rotating speed of setting high energy ball mill is 200 revs/min ~ 400 revs/min; ball milling 40 minutes ~ 1 hour, shuts down cooling 20 ~ 30 minutes, obtains the nanometer powder of 100nm ~ 300nm.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when dosage form is soup decoct, be specially:
Described each raw material components is mixed by weight, obtain mixture, add the water relative to mixture quality 3 ~ 5 times, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, filtering residue adds the water relative to 2 ~ 4 times, mixture again, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, mixed the filtrate of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup decoct.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 soup decoct
By Rhizoma Drynariae 55g, Caulis Sargentodoxae 35g, Caulis Polygoni Multiflori 70g, Cortex Acanthopancis 35g, Radix Et Caulis Acanthopanacis Senticosi 40g, Lignum Sappan 25g, Folium Et Cacumen Murrayae 35g, Herba Gendarussae 30g, Resina Liquidambaris 25g, Ramulus Sambuci Williamsii 40g, Herba Visci 30g, Caulis Gneti 35g, Radix Achyranthis Bidentatae 45g, Radix Codonopsis 55g, Herba Haleniae Corniculatae 25g, Herba Hyperici Sampsonii 30g, Myrrha 40g, Herba Fici Simplicissimae 35g, Radix Glycyrrhizae 30g, Caulis et folium cryptotaeniae japonicae 30g and Caulis Bauhihiae Championii 40g mixes, obtain mixture, add the water of 3.2kg, with slow fire boiling 4 hours, decoction liquor filter-cloth filtering, filtering residue adds the water relative to mixture 2.5kg again, with slow fire boiling 4 hours, decoction liquor filter-cloth filtering, the filtrate of twice is mixed, being concentrated into crude drug concentration is 1g/ml, obtain soup decoct 1.
Embodiment 2 powder
By Rhizoma Drynariae 55g, Caulis Sargentodoxae 35g, Caulis Polygoni Multiflori 70g, Cortex Acanthopancis 35g, Radix Et Caulis Acanthopanacis Senticosi 40g, Lignum Sappan 25g, Folium Et Cacumen Murrayae 35g, Herba Gendarussae 30g, Resina Liquidambaris 25g, Ramulus Sambuci Williamsii 40g, Herba Visci 30g, Caulis Gneti 35g, Radix Achyranthis Bidentatae 45g, Radix Codonopsis 55g, Herba Haleniae Corniculatae 25g, Herba Hyperici Sampsonii 30g, Myrrha 40g, Herba Fici Simplicissimae 35g, Radix Glycyrrhizae 30g, Caulis et folium cryptotaeniae japonicae 30g and Caulis Bauhihiae Championii 40g mixes, pulverize and sieve through Universalpulverizer, obtain 100 object powder, it is the alcohol reflux 3 times of 90% by the powder 2.5kg determining alcohol of acquisition, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain and get dry extract, the dry cream obtained is put into high energy ball mill, evacuation, pour the argon of 0.1MPa as protective gas, the rotating speed of setting high energy ball mill is 300 revs/min, ball milling 1 hour, shut down cooling 30 minutes, obtain the nanometer powder of about 150nm.
Embodiment 4 toxicological experiment
Acute toxicity testing
Select Kunming mouse 20, female half and half, body weight (20+2) g, is provided by Qingdao City's Experimental Animal Center, and decocting liquid prepared by embodiment 1 is gavaged mice, through preliminary experiment, fails to detect the LD of oral administration
50, therefore survey its maximum tolerated dose, with the administration volume of 1.4ml/10g body weight, gavage 2 times/d, interval 6h, to observation post administration 7d, record animal dead and toxicity symptom, at the end of experiment, by all animals process, dissect, perusal each main organs lesion tissue situation, after gavaging 140g crude drug/kg for 2 times, animal activity, feed water inlet does not show any abnormalities, observe 7d animal dead, gross necropsy has no the obvious exception of main organs tissue, therefore, the maximum dosage-feeding of Chinese medicine granules is > 140g crude drug/kg, this dosage is equivalent to 70 times of maximum oral dose 2g crude drug/kg clinical adult (by 60kg) every day.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, thered is provided by Qingdao City's Experimental Animal Center, be divided into 2 groups at random, blank group and Chinese drug-treated group, often organize 20, blank group gives distilled water, decocting liquid prepared by embodiment 1 is gavaged rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, and continuous 180d, administration volume is 2mL/100g body weight, and every day observes rat general state, sign, food ration, drinking-water and feces situation before administration and during administration.During administration 90d after last administration 24h, the extraction 6 of each group, male and female half and half; During 180d after last administration 24h, the extraction 6 of each group, male and female half and half; After drug withdrawal, 30d respectively organizes extraction 6, male and female half and half, anaesthetize with urethane, blood is got from abdominal aortic, each group is all killed and gets animal, checks hematology and blood parameters, after getting blood, amass wealth by heavy taxation at once core, liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, the internal organs such as prostate weigh, and make pathological examination according to weight calculator official weight coefficient.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, animal has no dead, naked eyes have no obvious pathological changes, each group of rat peripheral hemogram checking is all in normal range, and physiochemical indice is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient does not have significant difference compared with blank group.
Embodiment 4 clinical data
Choose the 170 routine patients that orthopedics department in December, 2010 to 2012 is accepted for medical treatment year June, be divided into experimental group and matched group at random, experimental group 85 example, man 46 example, female 39 example; 10 ~ 61 years old age, average (36.2 ± 5.1) year, wherein 13 routine wrist-joints fracture, 17 routine supracondylar fracture of the humerus, 11 routine olecranal fractures, 11 routine fracture of capitulum radii, 18 routine fractures of calcaneus, 9 routine medial and lateral malleolus fracture, 6 routine Patella fracturies; Matched group 85 example, man 44 example, female 41 example; 9 ~ 58 years old age, average (35.1 ± 3.3) year, wherein 16 routine wrist-joints fracture, 12 routine supracondylar fracture of the humerus, 14 routine olecranal fractures, 10 routine fracture of capitulum radii, 13 routine fractures of calcaneus, 12 routine medial and lateral malleolus fracture, 8 routine Patella fracturies.Two groups of patients, at the no significant difference (P > 0.05) of sex, age, fracture site, have comparability.
Therapeutic Method
The fracture site that displacement occurs after fracture is recovered normal or close to original normal position, after the reduction of the fracture, implements fixing by matched group and test group again.Adopt the extenal fixation such as clamping plate, plaster bandage, exterior fixation bracket depending on concrete condition, if extenal fixation be difficult to carry out by surgical incision, use titanium alloy plate, intramedullary needle, screw or draw point internal fixtion.
Matched group takes Western medicine: vitamin B
10mg/ time, day 3 times; Compound recipe chrondroitin sheet 5 pieces/times, day 3 times; Calcium gluconate tablet 2g/ time, day 3 times 10 days is 1 course for the treatment of, is used in conjunction 9 courses for the treatment of, also will carry out functional exercise depending on patients with fractures's recovery situation, prevent joint accretion.
Test group: soup decoct prepared by oral embodiment 1, daily 3 times, each 200ml, simultaneously, adopt powder fumigation treatment prepared by embodiment 2, said medicine powder fritter gauze is wrapped rear input in the basin containing clear water 5000ml by medicine name and soaks 30min, 30min is boiled after soaking 30min, patient's suffering limb is placed on support, under medicinal liquid basin is placed on support, cover with towel list above, make to form a confined space between limbs and medicine basin, steam steaming affected part about the 30min of medicinal liquid, dips in drug application with towel and washes affected part when fluid temperature is suitable for.Curative effect is soaked more desirable as suffering limb inserted in container.Fumigation and wash method 2 times on the 1st, about 30min at every turn, the 2nd washing liquid can direct heating, and 7d is a course for the treatment of.Note the subjective symptoms of observing fluid temperature, patient in fumigation and wash method process, prevent patient skin from scalding, pay special attention to the various discomfort reactions of old man and child simultaneously.(2) functional exercise: fumigation and wash method does simultaneously stretches the active and passive functional exercise such as in the wrong, proceeds regular orderly functional exercise after fumigation and wash method.Attention: (1) local wound does not heal or skin ulceration person avoids use; (2) occur that erythema person avoids use after applying washout side; (3) merging severe cardiac cerebrovascular disease person and glycosuria patient are cautious use of.
The standard of curative effect evaluation
X-ray film prompting fracture line disappears completely, and firmly, without malunion, adjacent joints pain is not obvious, and mobility is well excellent in healing.X-ray film points out obvious seriality callus, and fuzzy fracture line is visible, and without obviously lopsided, adjacent joints mild pain is uncomfortable, and activity is slightly limited as well.X-ray film prompting callus is few discontinuous, and obvious fracture line is visible, mild malformation, and adjacent joints pain is obvious, and limitation of activity is can.X-ray film prompting is without growth of spur, and obviously, adjacent joints pain is serious for deformity, and movable critical constraints is for poor.Acceptance rate=(excellent+good)/number of cases.
Data process&analysis
Each group of data all use mean soil standard deviation
represent, each group mean does test of normality and repeated measure homogeneity test of variance, with inspection younger between one factor analysis of variance group), P < 0.05 is for differing significantly, and P < 0.01 is difference highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Result
Followed up a case by regular visits to through 6 ~ 12 months, the results are shown in Table 1.
Comparitive study (%) before and after table 1 liang group treatment
| Group | Number of cases (n) | Excellent | Good | Can | Difference | Acceptance rate |
| Test group | 85 | 51 | 27 | 5 | 2 | 91.77％ |
| Matched group | 85 | 39 | 29 | 9 | 8 | 80％ |
As can be seen from Table 1, adopt Chinese medicine composition provided by the invention, it promotes that the effect of fracture surgery rehabilitation will significantly better than matched group, and P < 0.05, has comparability.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. for promoting a Chinese medicine composition for fracture recovering, it is characterized in that: crude drug is made up of Rhizoma Drynariae, Caulis Sargentodoxae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Radix Et Caulis Acanthopanacis Senticosi, Lignum Sappan, Folium Et Cacumen Murrayae, Herba Gendarussae, Resina Liquidambaris, Ramulus Sambuci Williamsii, Herba Visci, Caulis Gneti, Radix Achyranthis Bidentatae, Radix Codonopsis, Herba Haleniae Corniculatae, Herba Hyperici Sampsonii, Myrrha, Herba Fici Simplicissimae, Radix Glycyrrhizae, Caulis et folium cryptotaeniae japonicae and Caulis Bauhihiae Championii, the weight portion of each crude drug is Rhizoma Drynariae 50 weight portion ~ 60 weight portions, Caulis Sargentodoxae 30 weight portion ~ 40 weight portion, Caulis Polygoni Multiflori 65 weight portion ~ 75 weight portion, Cortex Acanthopancis 30 weight portion ~ 40 weight portion, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion ~ 45 weight portion, Lignum Sappan 20 weight portion ~ 30 weight portion, Folium Et Cacumen Murrayae 30 weight portion ~ 40 weight portion, Herba Gendarussae 25 weight portion ~ 35 weight portion, Resina Liquidambaris 20 weight portion ~ 30 weight portion, Ramulus Sambuci Williamsii 35 weight portion ~ 45 weight portion, Herba Visci 25 weight portion ~ 35 weight portion, Caulis Gneti 30 weight portion ~ 40 weight portion, Radix Achyranthis Bidentatae 40 weight portion ~ 50 weight portion, Radix Codonopsis 50 weight portion ~ 60 weight portion, Herba Haleniae Corniculatae 20 weight portion ~ 30 weight portion, Herba Hyperici Sampsonii 25 weight portion ~ 35 weight portion, Myrrha 35 weight portion ~ 45 weight portion, Herba Fici Simplicissimae 30 weight portion ~ 40 weight portion, Radix Glycyrrhizae 25 weight portion ~ 35 weight portion, Caulis et folium cryptotaeniae japonicae 25 weight portion ~ 35 weight portion and Caulis Bauhihiae Championii 35 weight portion ~ 45 weight portion.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each crude drug is Rhizoma Drynariae 53 weight portion ~ 57 weight portions, Caulis Sargentodoxae 33 weight portion ~ 37 weight portion, Caulis Polygoni Multiflori 68 weight portion ~ 72 weight portion, Cortex Acanthopancis 33 weight portion ~ 37 weight portion, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion ~ 42 weight portion, Lignum Sappan 23 weight portion ~ 27 weight portion, Folium Et Cacumen Murrayae 33 weight portion ~ 37 weight portion, Herba Gendarussae 28 weight portion ~ 32 weight portion, Resina Liquidambaris 23 weight portion ~ 27 weight portion, Ramulus Sambuci Williamsii 38 weight portion ~ 42 weight portion, Herba Visci 28 weight portion ~ 32 weight portion, Caulis Gneti 33 weight portion ~ 37 weight portion, Radix Achyranthis Bidentatae 43 weight portion ~ 47 weight portion, Radix Codonopsis 53 weight portion ~ 57 weight portion, Herba Haleniae Corniculatae 23 weight portion ~ 27 weight portion, Herba Hyperici Sampsonii 28 weight portion ~ 32 weight portion, Myrrha 38 weight portion ~ 42 weight portion, Herba Fici Simplicissimae 33 weight portion ~ 37 weight portion, Radix Glycyrrhizae 28 weight portion ~ 32 weight portion, Caulis et folium cryptotaeniae japonicae 28 weight portion ~ 32 weight portion and Caulis Bauhihiae Championii 38 weight portion ~ 42 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is Rhizoma Drynariae 55 weight portion, Caulis Sargentodoxae 35 weight portion, Caulis Polygoni Multiflori 70 weight portion, Cortex Acanthopancis 35 weight portion, Radix Et Caulis Acanthopanacis Senticosi 40 weight portion, Lignum Sappan 25 weight portion, Folium Et Cacumen Murrayae 35 weight portion, Herba Gendarussae 30 weight portion, Resina Liquidambaris 25 weight portion, Ramulus Sambuci Williamsii 40 weight portion, Herba Visci 30 weight portion, Caulis Gneti 35 weight portion, Radix Achyranthis Bidentatae 45 weight portion, Radix Codonopsis 55 weight portion, Herba Haleniae Corniculatae 25 weight portion, Herba Hyperici Sampsonii 30 weight portion, Myrrha 40 weight portion, Herba Fici Simplicissimae 35 weight portion, Radix Glycyrrhizae 30 weight portion, Caulis et folium cryptotaeniae japonicae 30 weight portion and Caulis Bauhihiae Championii 40 weight portion.
4. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine composition is soup decoct or powder.
5. the preparation method of Chinese medicine composition described in claim 1 or 2, is characterized in that: when the dosage form of this Chinese medicine composition is powder, be specially,
The first step, by described each raw material medicaments in part by weight mixing, pulverizes and sieves through Universalpulverizer, obtains 100 order ~ 200 object powder;
Second step, is the alcohol reflux 2 times ~ 4 times of 80% ~ 90% by the powder determining alcohol that the first step obtains, filters, merging filtrate, and concentrating under reduced pressure removing ethanol, obtains and get dry extract, and wherein, the amount of the ethanol added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step; the dry cream that second step obtains is put into high energy ball mill; evacuation; pour the argon of 0.1MPa as protective gas; the rotating speed of setting high energy ball mill is 200 revs/min ~ 400 revs/min; ball milling 40 minutes ~ 1 hour, shuts down cooling 20 ~ 30 minutes, obtains the nanometer powder of 100nm ~ 300nm.
6. the preparation method of Chinese medicine composition described in claim 1 or 2, is characterized in that: when dosage form is soup decoct, be specially,
By described each raw material medicaments in part by weight mixing, obtain mixture, add the water relative to mixture quality 3 ~ 5 times, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, filtering residue adds the water relative to 2 ~ 4 times, mixture again, with slow fire boiling 2 ~ 4 hours, decoction liquor filter-cloth filtering, mixed the filtrate of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup decoct.
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| CN101703692A (en) * | 2009-11-05 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating bone fracture and preparation method thereof |
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