CN103316252A - 一种治疗肝纤维化的中药 - Google Patents
一种治疗肝纤维化的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗肝纤维化的中药，由以下重量配比的药材制备而成：狗脚迹12份、大沙叶14份、川谷根12份、寸节七10份、蓝花石参9份、乌金草8份、臭常山8份、飞来鹤8份、雪茶14份、一匹草12份、黄水枝10份、鸡肫草14份、羽叶三七12份、吊岩风10份、刺梨子12份、蟛蜞菊12份、岩丸子14份、石油菜12份、臭威灵12份。临床实验证明，本发明能够安全有效治疗肝纤维化。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗肝纤维化的中药。
背景技术
肝纤维化是指由各种致病因子所致肝内***异常增生，导致肝内弥漫性细胞外基质过度沉淀的病理过程它不是一个独立的疾病，而是许多慢性肝脏疾病均可引起肝纤维化，一般用化纤舒肝方都能治好。其病因大致可分为感染性(慢性乙型、丙型和丁型病毒性肝炎，血汲虫病等)，先天性代谢缺陷(肝豆状核变性、血色病、α1-抗胰蛋白酶缺乏症等)及化学代谢缺陷(慢性酒精性肝病、慢性药物性肝病)及自身免疫性肝炎、原发性肝汁性肝硬化和原发性硬化性胆管炎等。
对于肝纤维化目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
狗脚迹【来源】锦葵科梵天花属植物梵天花Urena procumbens L.，以根和叶入药。秋季挖根，夏秋采叶，洗净切碎，晒干。【功能主治】祛风利湿，清热解毒。用于感冒，风湿性关节炎，肠炎，痢疾，肺热咳嗽；外用治跌打损伤，疮疡肿毒，毒蛇咬伤。
大沙叶【来源】茜草科大沙叶属植物满天星Pavetta hongkongensis Brem.，以全株、根、叶入药。四季可采，将根、叶等分别晒干。【功能主治】清热解暑，活血祛瘀。用于中暑，感冒发热，肝炎，跌打损伤。
川谷根【来源】禾本科薏苡属植物川谷Coix lachrymajobi L.，以根及根状茎入药。秋季采收根部，晒干。【功能主治】清热，利湿，杀虫。用于***，***，水肿，脚气，蛔虫病，白带过多。
寸节七【来源】为堇菜科堇菜属植物大叶堇菜Viola diamantiaca Nakai，以全草入药。夏末采收，洗净，晒干。【功能主治】清热解毒，止血。用于疮疖肿毒，麦粒肿，毒蛇咬伤，外伤出血。
蓝花石参【来源】桔梗科风铃草属植物西南风铃草Campanula colorata Wall.，以根入药。夏秋采集，洗净晒干或鲜用。【功能主治】祛风，利湿，止血。用于风湿关节炎，破伤风，肺结核咯血。
乌金草【来源】龙胆科獐牙菜属植物乌金草Swertia heterantha Ling的带根全草。秋季采挖，洗净晒干。【功能主治】平肝，强心，养血调经。用于血虚头晕，神经衰弱，高血压症，***。
臭常山【来源】芸香科臭常山属植物臭常山Orixa japonica Thunb.，以根、茎、叶入药。根、茎四季可采，晒干；叶夏秋采集，鲜用。【功能主治】清热利湿，截疟，止痛，安神。用于风热感冒，风湿关节肿痛，胃痛，疟疾，跌打损伤，神经衰弱；外用治痈肿疮毒。
飞来鹤【来源】为萝藤科牛皮消属植物飞来鹤(耳叶牛皮消)Cynanchum auriculatum Royle exWight，以根或全草入药。【功能主治】健胃消积，解毒消肿。用于食积腹痛，胃痛，小儿疳积，痢疾；外用治毒蛇咬伤，疔疮。
雪茶【来源】地衣类地茶科地茶属植物雪地茶，以叶状体入药。四季可采，去杂质，晒干。【功能主治】清热，安神。用于中暑，心中烦热，阴虚潮热，肺热咳嗽，神经衰弱，高血压病。
一匹草【来源】兰科卷瓣兰属植物梳帽卷瓣兰Cirrhopetalnm andersonii Hook.f.，以全草入药。四季可采，鲜用或晒干。【功能主治】祛风除湿，活血，止咳，消食积。用于跌打损伤，妇女体虚，小儿咳嗽，百日咳。
黄水枝【来源】虎耳草科黄水枝属植物黄水枝Tiarella polyphylla D.Don，以全草入药。夏秋采集，晒干。【功能主治】清热解毒，活血祛瘀，消肿止痛。用于痈疖肿毒，跌打损伤，肝炎，咳嗽气喘。
鸡肫草【来源】为虎耳科梅花草属植物鸡眼梅花草Parnassia wightiana Wall.以全草入药。夏秋采集全草，洗净晒干。【功能主治】清肺止咳，利水祛湿。用于久咳咯血，疟疾，肾结石，胆石症，白带，跌打损伤；外用治湿热疮毒。
羽叶三七【来源】为五加科人参属植物羽叶三七Panax bipinnatifidus Seem.，以根状茎入药。秋末采挖，洗净晒干备用。【功能主治】滋补强壮，散瘀止痛，止血。用于病后虚弱，肺结核咯血，衄血，闭经，产后血瘀腹痛，寒湿痹痛，跌打损伤。
吊岩风【来源】葡萄科爬山虎属植物异叶爬山虎Parthenocissus heterophyllus(Blume)Merr.，以根、茎入药。秋季采，洗净切片，晒干。【功能主治】祛风活络，活血止痛。用于风湿筋骨痛，赤白带下，产后腹痛；外用治骨折，跌打肿痛，疮疖。
刺梨子【来源】蔷薇科蔷薇属植物刺梨Rosa roxburghii Tratt.，以根及果入药。夏季采果，秋季挖根，晒干或鲜用。【功能主治】根：消食健脾，收敛止泻。用于食积腹胀，痢疾，肠炎，自汗盗汗，遗精，白带，月经过多，痔疮出血。果：解暑，消食。治维生素C缺乏症。
蟛蜞菊【来源】菊科蟛蜞菊属植物蟛蜞菊Wedelia chinensis Merr.，以全草入药。夏秋采收，洗净，鲜用或晒干。【功能主治】清热解毒，化痰止咳，凉血平肝。用于预防麻疹，感冒发热，白喉，咽喉炎，扁桃体炎，支气管炎，肺炎，百日咳，咯血，高血压；外用治疔疮疖肿。
岩丸子【来源】秋海棠科秋海棠属植物柔毛秋海棠Begonia henryi Hemsl.，以块茎入药。秋后挖取块茎，洗净晒干或鲜用。【功能主治】解毒，散瘀，止血。用于跌打损伤，狂犬咬伤，红崩白带；外用治骨折。
石油菜【来源】荨麻科冷水花属植物波缘冷水花Pilea cavaleriei Levl.，以全草入药。全年可采，鲜用或晒干。【功能主治】清热解毒，润肺止咳，消肿止痛。用于肺热咳嗽，肺结核病，肾炎水肿；外用治跌打损伤，烧烫伤，疮疖肿毒。
臭威灵【来源】菊科风毛菊属植物棉毛风毛菊Saussurea lanuginosa Vant.，以根入药。夏秋采集，洗净切碎晒干。【功能主治】润肺止咳，解毒止痛。用于肺结核，支气管炎，咯血，偏头痛；外用治狂犬咬伤。
发明内容
本发明旨在提供一种治疗肝纤维化的中药，通过选择合适的药材及其配比，达到安全有效治愈肝纤维化的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗肝纤维化的中药，其特征在于，由以下重量配比的药材制备而成：狗脚迹12份、大沙叶14份、川谷根12份、寸节七10份、蓝花石参9份、乌金草8份、臭常山8份、飞来鹤8份、雪茶14份、一匹草12份、黄水枝10份、鸡肫草14份、羽叶三七12份、吊岩风10份、刺梨子12份、蟛蜞菊12份、岩丸子14份、石油菜12份、臭威灵12份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年12月-2011年1月间共收集260例肝纤维化的门诊患者，年龄19-58岁，病程1-7年。随机分为：治疗组200例，空白组60例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(％) |
| 治疗组 | 200 | 20(10％) | 135(67.5％) | 45(22.5％) | 77.5％ |
| 空白组 | 60 | 0 | 6(10％) | 50(90％) | 10％ |
可见，本发明制得的药物能够安全有效治肝纤维化。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：狗脚迹12克、大沙叶14克、川谷根12克、寸节七10克、蓝花石参9克、乌金草8克、臭常山8克、飞来鹤8克、雪茶14克、一匹草12克、黄水枝10克、鸡肫草14克、羽叶三七12克、吊岩风10克、刺梨子12克、蟛蜞菊12克、岩丸子14克、石油菜12克、臭威灵12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肝纤维化。口服，每日分早晚两次服用。
具体实施例2
称取：狗脚迹12克、大沙叶14克、川谷根12克、寸节七10克、蓝花石参9克、乌金草8克、臭常山8克、飞来鹤8克、雪茶14克、一匹草12克、黄水枝10克、鸡肫草14克、羽叶三七12克、吊岩风10克、刺梨子12克、蟛蜞菊12克、岩丸子14克、石油菜12克、臭威灵12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗肝纤维化。口服，每日分早晚两次服用。
具体实施例3
称取：狗脚迹12克、大沙叶14克、川谷根12克、寸节七10克、蓝花石参9克、乌金草8克、臭常山8克、飞来鹤8克、雪茶14克、一匹草12克、黄水枝10克、鸡肫草14克、羽叶三七12克、吊岩风10克、刺梨子12克、蟛蜞菊12克、岩丸子14克、石油菜12克、臭威灵12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗肝纤维化。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗肝纤维化的中药，其特征在于，由以下重量配比的药材制备而成：狗脚迹12份、大沙叶14份、川谷根12份、寸节七10份、蓝花石参9份、乌金草8份、臭常山8份、飞来鹤8份、雪茶14份、一匹草12份、黄水枝10份、鸡肫草14份、羽叶三七12份、吊岩风10份、刺梨子12份、蟛蜞菊12份、岩丸子14份、石油菜12份、臭威灵12份。
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| CN113244281A (zh) * | 2021-06-09 | 2021-08-13 | 贵州医科大学 | 黄水枝醇提物在制备治疗或保护、调节肝纤维化疾病药物中的应用 |
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| CN101176780A (zh) * | 2006-11-10 | 2008-05-14 | 辽宁中医药大学附属医院 | 一种治疗肝纤维化及早期肝硬化的药物 |
| CN101632829A (zh) * | 2009-09-03 | 2010-01-27 | 福建归真堂药业股份有限公司 | 一种抗肝纤维化的中药组合物及其制备方法与药物制剂 |
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| CN103751462A (zh) * | 2014-02-08 | 2014-04-30 | 刘方荣 | 一种治疗风热血燥型脂溢性皮炎的中药酊剂 |
| CN113244281A (zh) * | 2021-06-09 | 2021-08-13 | 贵州医科大学 | 黄水枝醇提物在制备治疗或保护、调节肝纤维化疾病药物中的应用 |
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