CN103599328B - 一种治疗肺泡蛋白沉着症的中药 - Google Patents
一种治疗肺泡蛋白沉着症的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗肺泡蛋白沉着症的中药，由以下重量配比的药材制备而成：绣线菊15份、飞蛾藤12份、佛甲草12份、二歧银莲花根10份、方儿茶10份、地苏木12份、鞑新菊14份、凤庆鸡血藤18份、粉萆薢8份、滇常山花22份、对叶油麻叶20份、多蒴曲尾藓16份、风叶藤15份、复叶披麻草根10份、羽叶三七14份、打碗花16份、粪鬼伞12份。临床实验证明，本发明能够安全有效治疗肺泡蛋白沉着症。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗肺泡蛋白沉着症的中药。
背景技术
肺泡蛋白沉着症（PAP）是一种原因未明的少见疾病。其特点是肺泡内有不可溶性富磷脂蛋白沉积，临床症状主要表现为气短、咳嗽和咳痰。胸部X线呈双肺弥漫性肺部浸润阴影。病理学检查以肺泡内充满有过碘酸雪夫（PAS）染色阳性的蛋白样物质为特征。本病的临床表现差异很大，有的可无任何临床症状，仅在体检时发现；约有1/5的病人则以继发性肺部感染症状为首发表现，有咳嗽、发热、胸部不适等；另有约1/2的病人隐袭起病，表现为咳嗽、呼吸困难、乏力，少数病例可有低热和咯血，呼吸道症状与肺部病变受累范围有一定关系。
对于肺泡蛋白沉着症目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
绣线菊【来源】蔷薇科绣线菊属植物光叶绣线菊，以根及嫩叶入药。全年采根，洗净晒干；嫩叶夏季采。【功能主治】清热解毒。用于目赤肿痛，头痛，牙痛，肺热咳嗽；外用治创伤出血。
飞蛾藤【来源】旋花科飞蛾藤Porana racemosa Roxb.，以全草入药。【功能主治】发表、消食积。主治伤风感冒，食积不消。
佛甲草【来源】为景天科植物佛甲草的茎叶。鲜用随采；或夏、秋两季，拔出全株，洗净，放开水中烫一下，捞起，晒干或炕干。【功能主治】清热解毒；利湿；止血。主咽喉肿痛；目赤肿毒；热毒痈肿；疔疮；丹毒；缠腰火丹；烫火伤；毒蛇咬伤；黄疸；湿热泻痢；便血；崩漏；外伤出血；扁平疣。
二歧银莲花根【来源】为毛茛科植物二歧银莲花的根茎。秋季采挖，晒干。【功能主治】舒筋活血；清热解毒。主跌打损伤；风湿性关节炎；痢疾；疮痈。
方儿茶【来源】为茜草科植物儿茶钩藤带叶嫩枝煎汁浓缩而成的干浸膏。为茜草科植物儿茶钩藤带叶嫩枝煎汁浓缩而成的干浸膏。
地苏木【来源】为金星蕨科植物披针新月蕨的根茎及全草。秋季采收。【功能主治】散瘀血，除湿。治跌打腰痛，血凝气滞。
鞑新菊【来源】为菊科植物鞑新菊的头状花序。8～9月采花，阴干。【功能主治】活血，祛湿，消炎，止痛。治跌打损伤，湿热症。
凤庆鸡血藤【来源】为五味子科植物内南五味子或异型南五味子的藤茎。秋季采收，洗净晒干用，或熬膏用。【功能主治】生血和血；调经种子。主气血虚弱；肢麻瘫痪；风湿痹痛；虚损不育；遗精白浊；***；赤白带下。
粉萆薢【来源】本品为薯蓣科植物粉背薯蓣 Dioscorea hypoglauca Palibin 的干燥根茎。秋、冬二季采挖，除去须根，洗净，切片，晒干。【功能主治】利湿去浊，祛风除痹。用于膏淋，白浊，白带过多，风湿痹痛，关节不利，腰膝疼痛。
滇常山花【来源】为马鞭草科植物滇常山的花。4-7月开花时采收，晾干。【功能主治】止血；止带。主崩漏；带下。
对叶油麻叶【来源】为忍冬植物台东荚蒾的茎叶。春、夏季采收，鲜用。【功能主治】散瘀止痛；通便。主跌打损伤；便秘。
多蒴曲尾藓【来源】为曲尾藓科植物多蒴曲尾藓的植物体。夏、秋季采收，洗净，晒干。【功能主治】清肺止咳。主肺热咳嗽。
风叶藤【来源】葡萄科风叶藤Cissus assamica （Laws.） Craib，以根入药。【功能主治】拔脓消肿，散瘀止痛。主治跌打损伤，扭伤，风湿关节疼痛，骨折，痈疮肿毒。配方用尚可治骨髓炎。亦可作滋补剂。
复叶披麻草根【来源】为毛茛科植物复叶披麻草的根。秋、冬采收，洗净晒干。【功能主治】清热燥湿，凉血解毒。治烦热口渴，胸闷呕吐，吐血衄血，湿热泻痢，目赤口疮，痈肿疔毒，湿热发黄。
羽叶三七【来源】为五加科人参属植物羽叶三七Panax bipinnatifidus Seem.，以根状茎入药。秋末采挖，洗净晒干备用。【功能主治】滋补强壮，散瘀止痛，止血。用于病后虚弱，肺结核咯血，衄血，闭经，产后血瘀腹痛，寒湿痹痛，跌打损伤。
打碗花【来源】为旋花科打碗花属植物打碗花Calystegin hederacea Wall.，以根状茎及花入药。秋季挖根状茎，洗净晒干或鲜用。夏秋采花鲜用。【功能主治】健脾益气，利尿，调经，止带；用于脾虚消化不良，***，白带，乳汁稀少。止痛；外用治牙痛。
粪鬼伞【来源】真菌类担子菌纲伞菌目伞菌科粪鬼伞Coprinus sterquilinus Fr.，以子实体入药。【功能主治】益肠胃，化痰理气，解毒，消肿。经常食用可以助消化，祛痰，并治无名肿毒和其它疮痈。
发明内容
本发明旨在提供一种治疗肺泡蛋白沉着症的中药，通过选择合适的药材及其配比，达到安全有效治愈肺泡蛋白沉着症的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗肺泡蛋白沉着症的中药，其特征在于，由以下重量配比的药材制备而成：绣线菊15份、飞蛾藤12份、佛甲草12份、二歧银莲花根10份、方儿茶10份、地苏木12份、鞑新菊14份、凤庆鸡血藤18份、粉萆薢8份、滇常山花22份、对叶油麻叶20份、多蒴曲尾藓16份、风叶藤15份、复叶披麻草根10份、羽叶三七14份、打碗花16份、粪鬼伞12份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年9月-2012年11月间共收集98例肺泡蛋白沉着症的门诊患者，年龄31-58岁，病程1-4年。随机分为：治疗组91例，空白组27例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 91 | 31（34.1%） | 37（40.6%) | 23（25.3%) | 74.7% | 0 |
| 空白组 | 27 | 1(3.7%) | 3（11.1%） | 23（85.2%） | 14.8% | 0 |
可见，本发明制得的药物能够安全有效治疗肺泡蛋白沉着症。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：绣线菊15克、飞蛾藤12克、佛甲草12克、二歧银莲花根10克、方儿茶10克、地苏木12克、鞑新菊14克、凤庆鸡血藤18克、粉萆薢8克、滇常山花22克、对叶油麻叶20克、多蒴曲尾藓16克、风叶藤15克、复叶披麻草根10克、羽叶三七14克、打碗花16克、粪鬼伞12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肺泡蛋白沉着症。口服，每日分早晚两次服用。
具体实施例2
称取：绣线菊15克、飞蛾藤12克、佛甲草12克、二歧银莲花根10克、方儿茶10克、地苏木12克、鞑新菊14克、凤庆鸡血藤18克、粉萆薢8克、滇常山花22克、对叶油麻叶20克、多蒴曲尾藓16克、风叶藤15克、复叶披麻草根10克、羽叶三七14克、打碗花16克、粪鬼伞12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗肺泡蛋白沉着症。口服，每日分早晚两次服用。
具体实施例3
称取：绣线菊15克、飞蛾藤12克、佛甲草12克、二歧银莲花根10克、方儿茶10克、地苏木12克、鞑新菊14克、凤庆鸡血藤18克、粉萆薢8克、滇常山花22克、对叶油麻叶20克、多蒴曲尾藓16克、风叶藤15克、复叶披麻草根10克、羽叶三七14克、打碗花16克、粪鬼伞12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗肺泡蛋白沉着症。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗肺泡蛋白沉着症的中药，其特征在于，由以下重量配比的药材制备而成：绣线菊15份、飞蛾藤12份、佛甲草12份、二歧银莲花根10份、方儿茶10份、地苏木12份、鞑新菊14份、凤庆鸡血藤18份、粉萆薢8份、滇常山花22份、对叶油麻叶20份、多蒴曲尾藓16份、风叶藤15份、复叶披麻草根10份、羽叶三七14份、打碗花16份、粪鬼伞12份。
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| CN1736435A (zh) * | 2005-09-12 | 2006-02-22 | 陈沙 | 治疗鼻炎的中药颗粒制剂及其制备方法 |
| CN103301210A (zh) * | 2013-06-24 | 2013-09-18 | 周国生 | 一种治疗静脉曲张的中药 |
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| CN1736435A (zh) * | 2005-09-12 | 2006-02-22 | 陈沙 | 治疗鼻炎的中药颗粒制剂及其制备方法 |
| CN103301210A (zh) * | 2013-06-24 | 2013-09-18 | 周国生 | 一种治疗静脉曲张的中药 |
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