CN102940762B - 一种治疗痛风性关节炎的中药 - Google Patents
一种治疗痛风性关节炎的中药 Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种治疗痛风性关节炎的中药，由以下重量配比的药材制备而成：知母6份、牡丹皮6份、地肤子8份、车前子7份、莲须12份、大云6份、竹砂仁12份、武靴藤13份、山药15份、蜂蜜12份、金樱子8份、制马钱子7份、灵芝4份、肉桂4份、锁阳4份、巴戟天4份、菟丝子6份、杜仲8份、蛤蚧4份、金银花8份、夏枯草8份。临床实验证明，本发明能够安全有效治疗痛风性关节炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗痛风性关节炎的中药。
背景技术
风性关节炎由于尿酸盐沉积在关节囊、滑囊、软骨、骨质和其他组织中而引起病损及炎性反应，它多有遗传因素和家族因素，多见于拇趾的跖趾关节，也可发生于其他较大关节，尤其是踝部与足部关节。原发性痛风掌发现于40岁以上男性，女性较少且多为绝经期妇女，通常分为4期：无症状期、急性关节炎期、间歇期、间歇期。
对于痛风性关节炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
牡丹皮【来源】为毛茛科芍药属植物牡丹的根皮，含牡丹酚，牡丹酚甙，挥发油和植物甾醇等。【功能主治】牡丹皮有降低血压、镇痛、镇静、抗炎和解热作用；对多种致病菌有较强的抑制作用。其性凉，味苦、辛，功能清热，凉血、和血、清瘀，适用于热人血分，发斑、惊痛、吐血、痈疡，跌打损伤等症。
知母【来源】为百合科植物知母的根茎，含多种皂甙及皂甙之，此外还含有两种黄酮类成芒果甙等。【功能主治】知母有明显的解热作用，对流行性出血热、流行性乙型脑炎、肺结核潮热均有明显疗效。其性寒，味甘、苦，功能清热泻火、滋阴润燥，适用于肺热咳喘或阴虚咳嗽，烦热消渴，骨蒸劳热，小便不利，大便燥结等症。
地肤子【来源】藜科植物地肤 Kochia scoparia (L.) Schrad. 的干燥成熟果实。呈扁球状五角星形，气微，味微苦。【功能主治】清热利湿，祛风止痒。用于小便涩痛、阴痒带下、风疹、湿疹、皮肤瘙痒。
车前子【来源】又名车轮菜，多年生草本，甘；淡；性微寒。【功能主治】清热利尿；渗湿止泻；明目；祛痰。主治：主小便不利；淋浊带下；水肿胀满；暑湿泻痢；目赤障翳；痰热咳喘。
莲须【来源】该品为睡莲科植物莲NelumbonuciferaGaertn.的干燥雄蕊。夏季花开时选晴天采收，盖纸晒干或阴干。【功能主治】固肾涩精。用于遗精滑精，带下，尿频。
大云【来 源】为列当科植物肉苁蓉或苁蓉、迷肉苁蓉等的肉质茎。【功能主治】补肾助阳，润肠通便，软坚散结。
竹砂仁【来源】药材基源：为肉座菌科真菌竹小肉座菌的子座。【功能主治】祛风除湿；解毒止痒。主风湿性关节炎；外阴白斑。
武靴藤【来源】药材基源：为双子叶植物药萝藦科植物匙羹藤的根或嫩枝叶。【功能主治】清热凉血；排脓消肿；止痛生肌。主风湿痹痛；咽喉肿痛；瘰疬；乳痈；疮疖；湿疹；无名肿毒；毒蛇咬伤。
山药【来源】 多年生草本植物，茎蔓生，常带紫色，块根圆柱形，叶子对生，卵形或椭圆形，花乳白色，雌雄异株。块根含淀粉和蛋白质。【功能主治】 补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
蜂蜜【来源】是昆虫蜜蜂从开花植物的花中采得的花蜜在蜂巢中酿制的蜜。【功能主治】改善血液的成份，促进心脑和血管功能，补充体力，消除疲劳，增强对疾病的抵抗力。
金樱子【来源】常绿蔓性灌木，无毛根皮提制栲胶；果实入药。【功能主治】止咳平喘，抗痉挛，有利尿、补肾作用；抗菌消炎，降血脂。叶有解毒消肿作用；根药用，能活血散瘀、拔毒收敛、祛风驱湿。
制马钱子【来源】马钱科植物云南马钱的干燥成熟种子。主要成分是***。【功能主治】治伤寒热病，咽喉痹痛，消痞块，散血热，消肿毒。治痈疽，恶疮。
灵芝【来源】孔菌科真菌赤芝或紫芝的干燥子实体。用作药物的灵芝为赤芝和紫芝，其药性为甘，平。【功能主治】增强人体免疫力，调节血糖，控制血压，辅助肿瘤放化疗，保肝护肝，促进睡眠等。调节机体免疫功能、能有效抑制肿瘤生长和细胞突变、具有延缓衰老、抗脂肪肝、调节血脂和血糖、促进造血功能等方面的作用。
肉桂【来源】樟科植物肉桂 Cinnamomum cassia Presl 的干燥树皮，性大热，味辛、甘。【功能主治】补火助阳，引火归源，散寒止痛，活血通经。暖脾胃，除积冷，通血脉。治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭症瘕，阴疽，流注，及虚阳浮越，上热下寒。
锁阳【来源】 又名不老药，多年生肉质寄生草本。地下茎粗短，具有多数瘤突吸收根，野生于沙漠戈壁，生长之处不积雪、地不冻。【功能主治】有补肾润肠、治阳痿，尿血等功效。
巴戟天【来源】为双子叶植物茜草科（ Rubiaceae ）巴戟天 （Morinda officinalis How. ）的干燥根。【功能主治】主治阳痿遗精、宫冷***、***、少腹冷痛、风湿痹痛、筋骨痿软。
菟丝子【来源】双子叶植物药旋花科植物菟丝子、南方菟丝子、金灯藤等的种子。【功能主治】具有补肾益精、养肝明目、固胎止泄之功效。
杜仲【来源】杜仲科植物杜仲（Eucommia ulmoides Oliver）的干燥树皮，是中国名贵滋补药材。【功能主治】补肝肾、强筋骨、降血压、安胎等诸多功效。
蛤蚧【来源】该品呈扁片状，头颈部及躯干部长9～18cm，头颈部约占三分之一，身密被圆形或多角形微有光泽的细鳞，气腥，味微咸。【功能主治】补肺益肾，纳气平喘，助阳益精。治疗肺虚咳嗽，肾虚作喘，虚劳喘咳。
金银花【来源】金银花为忍冬科植物忍冬的花蕾，含绿原酸，肌醇，黄酮类成分等。【功能主治】金银花有抗炎和解热作用，对流感病毒和多种致病菌、皮肤致病真菌都有抑制作用，反映了金银花的清热解毒功效。其性寒，味甘，功能清热，解毒，适用于温病发热，热毒血痢，疮、痈、疖肿等热毒壅盛之症。
夏枯草【来源】夏枯草为唇形科植物夏枯草的花卉或全草，内含三萜皂甙及其甙元齐墩果酸，挥发油及维生素，氯化钾等。【功能主治】其性寒，味苦、辛，功能清肝火，散郁结，降血压，适用于肝火上炎所致的目赤肿痛，目珠疼痛，羞明流泪、头痛、眩晕等；用于痰火郁结所致的瘰疠，瘿瘤等。
发明内容
本发明旨在提供一种治疗痛风性关节炎的中药，通过选择合适的药材及其配比，达到安全有效治愈痛风性关节炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗痛风性关节炎的中药，其特征在于，由以下重量配比的药材制备而成：知母6份、牡丹皮6份、地肤子8份、车前子7份、莲须12份、大云6份、竹砂仁12份、武靴藤13份、山药15份、蜂蜜12份、金樱子8份、制马钱子7份、灵芝4份、肉桂4份、锁阳4份、巴戟天4份、菟丝子6份、杜仲8份、蛤蚧4份、金银花8份、夏枯草8份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2009年3月-2010年9月间共收集80例痛风性关节炎的门诊患者，年龄19-54岁，病程0.5-7年。随机分为：治疗组50例，空白组30例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) |
| 治疗组 | 50 | 10（20%） | 34（68%) | 6（12%) | 88% |
| 空白组 | 30 | 0 | 5（16.7%） | 25（83.3%） | 16.7% |
可见，本发明制得的药物能够安全有效治痛风性关节炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：知母6克、牡丹皮6克、地肤子8克、车前子7克、莲须12克、大云6克、竹砂仁12克、武靴藤13克、山药15克、蜂蜜12克、金樱子8克、制马钱子7克、灵芝4克、肉桂4克、锁阳4克、巴戟天4克、菟丝子6克、杜仲8克、蛤蚧4克、金银花8克、夏枯草8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗痛风性关节炎。口服，每日分早晚两次服用。
具体实施例2
称取：知母6克、牡丹皮6克、地肤子8克、车前子7克、莲须12克、大云6克、竹砂仁12克、武靴藤13克、山药15克、蜂蜜12克、金樱子8克、制马钱子7克、灵芝4克、肉桂4克、锁阳4克、巴戟天4克、菟丝子6克、杜仲8克、蛤蚧4克、金银花8克、夏枯草8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗痛风性关节炎。口服，每日分早晚两次服用。
具体实施例3
称取：知母6克、牡丹皮6克、地肤子8克、车前子7克、莲须12克、大云6克、竹砂仁12克、武靴藤13克、山药15克、蜂蜜12克、金樱子8克、制马钱子7克、灵芝4克、肉桂4克、锁阳4克、巴戟天4克、菟丝子6克、杜仲8克、蛤蚧4克、金银花8克、夏枯草8克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗痛风性关节炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗痛风性关节炎的中药，其特征在于，由以下重量配比的药材制备而成：知母6份、牡丹皮6份、地肤子8份、车前子7份、莲须12份、大云6份、竹砂仁12份、武靴藤13份、山药15份、蜂蜜12份、金樱子8份、制马钱子7份、灵芝4份、肉桂4份、锁阳4份、巴戟天4份、菟丝子6份、杜仲8份、蛤蚧4份、金银花8份和夏枯草8份。
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