CN103316056B - Radix isatidis coating dispersible tablet and preparation method thereof - Google Patents
Radix isatidis coating dispersible tablet and preparation method thereof Download PDFInfo
- Publication number
- CN103316056B CN103316056B CN201310253372.0A CN201310253372A CN103316056B CN 103316056 B CN103316056 B CN 103316056B CN 201310253372 A CN201310253372 A CN 201310253372A CN 103316056 B CN103316056 B CN 103316056B
- Authority
- CN
- China
- Prior art keywords
- radix isatidis
- coating
- coating solution
- tablet
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention provides a radix isatidis coating dispersible tablet and a preparation method thereof. A dispersible tablet core is prepared from the following raw materials in parts by weight: 20-30 parts of extraction of radix isatidis, 40-60 parts of microcrystalline cellulose, 10-15 parts of low substituted hydroxy propyl cellulose, 4-8 parts of croscarmellose sodium, 0.5-1 part of lauryl sodium sulfate, 0.5-1 part of gum acacia, 1-5 parts of lactose, 0-0.5 part of aromatic and 0-0.5 part of corrigent. The method comprises the following steps of carrying out wet granulation, totally mixing, and tabletting to prepare a phi12mm core with the tablet weight of 0.55-0.59g; and carrying out secondary coating to spray a film coating by using an opadry coating solution 1 and an opadry coating solution 2, and packing to obtain a finished product of the dispersible tablet. The radix isatidis coating dispersible tablet has excellent dispersion uniformity, is rapid to disintegrate and good in digesting performance, tablet surfaces of tablets in all the batches are even and have no chromatic aberration; and the tablet has no crack and uncoating phenomena and has good quality stability.
Description
Technical field
The present invention relates to dispersible tablet and preparation technology thereof, be specifically related to Radix Isatidis coated dispersing tablet and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.
Background technology
Radix Isatidis comes from the root of cruciferae isatis and careless Folium Isatidis, bitter in the mouth is cold in nature, it is a kind of application Chinese crude drug very widely, there is the effects such as heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving, detumescence, immunity of organisms and resistance can be improved, cure mainly tonsillitis, parotitis, laryngopharynx swelling and pain, to infectious hepatitis, infantile measles, there is preventive and therapeutic effect.
Current commercially available Radix Isatidis preparation mainly contains the preparations such as oral liquid, granule and conventional tablet, need to add a large amount of correctivess for regulating mouthfeel in oral agents and granule, but still the uncomfortable bitterness of Radix Isatidis cannot be covered completely, patient compliance is not high, and a dose is larger, times for spraying is many, carries inconvenience; Common
Radix Isatidis tablet dispersive property is not good, the medicine disintegration time long (on average needing more than 5 minutes), Gu onset is slow, and tablet appearance exists larger aberration (sepia and canescence), long-term placement easily produces sliver, easy dry linting, unilateral coarse, quality stability is poor, in addition, for moistureproof lucifuge and cover bad smell, often conventional tablet is carried out film coating, but be limited to existing art for coating, coating shelling phenomenon ubiquity.
Dispersible tablet means in water can the homodisperse tablet of disintegrate rapidly, it is a kind of quick-effective preparation that development in recent years is got up, for the solid preparation such as conventional tablet, capsule, dispersible tablet has taking convenience, disintegrate is rapid, absorption is fast and bioavailability advantages of higher, the untoward reaction of medicine can be reduced, the effective ingredient such as fat-soluble stronger organic acid, lignanoid are contained, at utmost improving bioavailability, by very necessary for Radix Isatidis prepared composition discrete piece in view of in Radix Isatidis.Application number CN200910017928.X and application number CN200410025111.4 patent all disclose a kind of dispersant isatis root tablet and preparation technology thereof, but be the nude film that bad smell is heavier, mouthfeel is not good, because Radix Isatidis raw material itself has extremely strong water absorption, long-term placement moisture-sensitive, affect mouthfeel and curative effect, in addition, dissolution rate and dissolution still need to be improved further all more than 100s disintegration for above-mentioned dispersible tablet.
Summary of the invention
In view of the foregoing defects the prior art has, the applicant improves on the basis of dispersible tablet formula, Extraction Technology of Radix Isatidis, tablet making technology, coating solution components and art for coating at primary study, provides a kind of Radix Isatidis coated dispersing tablet and preparation method thereof.The Radix Isatidis coated dispersing tablet that the method prepares has excellent dispersing uniformity, and disintegrate is rapid, and dissolving out capability is good, and each batch of unilateral uniform colorless of tablet is poor, and long-term placement is without sliver and coating shelling phenomenon, and quality stability is good.
Technical scheme of the present invention is as follows:
A kind of Radix Isatidis coated dispersing tablet, its label is made up of the raw material of following weight portion: Radix Isatidis extract 20 ~ 30 parts, microcrystalline Cellulose 40 ~ 60 parts, low-substituted hydroxypropyl cellulose 10 ~ 15 parts, cross-linking sodium carboxymethyl cellulose 4 ~ 8 parts, sodium lauryl sulphate 0.5 ~ 1 part, micropowder silica gel 0.5 ~ 1 part, lactose 1 ~ 5 part, aromatic 0 ~ 0.5 part, correctives 0 ~ 0.5 part;
Concrete preparation technology is: take by weight ratio after above-mentioned each raw material is crossed 100 mesh sieves respectively; First measure microcrystalline Cellulose, half amount cross-linking sodium carboxymethyl cellulose by Radix Isatidis extract, partly and partly measure low-substituted hydroxypropyl cellulose, mix homogeneously, with more than 70% ethanol wet method plasmid, oven dry, granulate; Remaining microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose is added again in gained granule, and sodium lauryl sulphate, micropowder silica gel, lactose, aromatic, correctives, mix homogeneously, tabletting, makes the φ 12mm label that sheet weighs 0.55 ~ 0.59g; Adopt secondary coating method to spray film coating, packaging, obtains coated dispersing tablet finished product;
Described Radix Isatidis extract preparation technology is: Radix Isatidis decoction pieces is shattered into coarse powder, first add the soak by water 55 ~ 60min of 10 times of weight, cross leaching filtrate, add the soak by water 45 ~ 48min of filtering residue 8 times of weight again, cross leaching filtrate, merge above-mentioned filtrate, being concentrated into relative density in 80 DEG C is 1.05 ~ 1.10, and adding 95% ethanol to alcohol content is 60wt%, leaves standstill, cold preservation 10 ~ 12h, filter, filtrate recycling ethanol, being concentrated into relative density in 80 DEG C is 1.05 ~ 1.15, spraying dry, obtains Radix Isatidis extract;
Described secondary coating method concrete technology is:
(1) preparation of Opadry coating solution
Get Opadry coating powder 1, with 80% ethanol for solvent is mixed with the Opadry coating solution 1 that solid content is 5 ~ 7wt%, be preferably 6 wt%, described Opadry coating powder 1 is made up of the raw material of following percentage by weight: hypromellose 5cp 60 ~ 70%, red ferric oxide 10 ~ 20%, titanium dioxide 5 ~ 10%, PEG400 5 ~ 10%, yellow ferric oxide 1 ~ 2%, Ponceau 4R aluminum lake 5 ~ 10%, indigo aluminum color lake 1 ~ 2%; Get Opadry coating powder 2, take water as the Opadry coating solution 2 that solvent is mixed with that solid content is 18 ~ 22wt%, be preferably 20 wt%, described Opadry coating powder 2 is made up of the raw material of following percentage by weight: polyvinyl alcohol 30 ~ 45%, Pulvis Talci 20 ~ 30%, red ferric oxide 10 ~ 20%, Macrogol 4000 10 ~ 15%, Fancy red aluminum lake 5 ~ 10%, soybean phospholipid 1 ~ 2%, Black Rouge 3 ~ 8%, Sunset yellow aluminum lake 1 ~ 2%;
(2) secondary coating
Get described label, first carry out film coating with described Opadry coating solution 1 according to weightening finish 0.5 ~ 1.5%, film coating is carried out according to weightening finish 1.5 ~ 2.5% again with described Opadry coating solution 2, preferably, first carry out film coating with described Opadry coating solution 1 according to weightening finish 1.0%, then carry out film coating with described Opadry coating solution 2 according to weightening finish 2.0%.
Its further technical scheme is:
Described coated dispersing tablet label is made up of the raw material of following weight portion: Radix Isatidis extract 23 ~ 27 parts, microcrystalline Cellulose 48 ~ 52 parts, low-substituted hydroxypropyl cellulose 12 ~ 16 parts, cross-linking sodium carboxymethyl cellulose 3 ~ 7 parts, sodium lauryl sulphate 0.5 ~ 1 part, micropowder silica gel 0.5 ~ 1 part, lactose 2 ~ 4 parts, aromatic 0.1 ~ 0.3 part, correctives 0.1 ~ 0.3 part.
Described aromatic is selected from vanillin.
Described correctives is selected from aspartame or caramel.
Compared with commercially available Radix Isatidis conventional tablet and existing dispersant isatis root tablet, Radix Isatidis coated dispersing tablet tool provided by the invention has the following advantages:
(1) from Extraction Technology of Radix Isatidis: extract yield of the present invention is high, extraction process is stablized.
(2) from label composition of raw materials and preparation technology: preparation technology's (wet granulation of the present invention, compressing dry granulation etc.) good stability, each batch of unilateral uniform colorless of tablet is poor, and adenosine content is even, prove this technique to adenosine isoreactivity material substantially without degraded and loss, ensure that product curative effect.
(3) from coating solution formula and art for coating: raw material Baphicacanthus cusia basic body tool high-hygroscopicity, fully isolated moisture is needed during preservation, and make after dispersible tablet is taken and need fully to be dissolved in water, for above-mentioned two kinds of characteristic contradictions, the invention provides a kind of coating solution formula (Opadry coating solution 1/ Opadry coating solution 2) and secondary coating method of uniqueness, the prediction of its principle is as follows: first form sealing coat not too closely by high concentration alcohol coating solution 1 on plain sheet surface, when bag second layer high-moisture coating solution 2, the moisture penetration label of appropriate amount, the stage reaching dissolving-recrystallization is unlikely to again while playing certain emollescence, two-layered coating synergism, the dissolving out capability of gained dispersible tablet and the more plain sheet of dispersed homogeneous degree also slightly improve, disintegration is 50 ~ 70s only, simultaneously, due to the buffer action of ground floor coating, coated tablet outward appearance is good, the not easily moisture absorption, after testing, Radix Isatidis coated dispersing tablet of the present invention has excellent dispersing uniformity, and disintegrate is rapid, and dissolving out capability is good, can significantly improve bioavailability, and long-term placement is without sliver and coating shelling phenomenon, and quality stability is good, this technique is equally applicable to the preparation of the bibulous coated dispersing tablet of other raw materials.
Detailed description of the invention
Further describe the present invention below in conjunction with embodiment, understand the present invention and advantage thereof and effect so that more deep.
If no special instructions, each source chemicals involved by following examples is domestic or Import Analysis net product, use each instrument and equipment to be this area conventional equipment.
radix Isatidis coated dispersing tablet prepares embodiment (embodiment 1 ~ embodiment 4)
In embodiment 1 ~ embodiment 4, Radix Isatidis coated dispersing tablet label raw materials and weight proportion thereof are see table 1.
Extraction Technology of Radix Isatidis is as follows:
Get commercially available Radix Isatidis decoction pieces 10kg and be ground into coarse powder, add the soak by water 60min of 10 times of weight for the first time, cross leaching filtrate, second time adds the soak by water 45min of 8 times of weight, crosses leaching filtrate, merges above-mentioned filtrate, being concentrated into relative density is 1.10(80 DEG C), add 95% ethanol and reach 60wt% to alcohol content, leave standstill, cold preservation 12h, filter, filtrate recycling ethanol, and to be concentrated into relative density be 1.15(80 DEG C), spraying dry, obtains Radix Isatidis extract.Detection and Extraction thing yield and adenosine total amount (result is see table 1).
Wet granulation, compressing dry granulation preparation technology are as follows:
Take by weight ratio after raw material components each shown in table 1 is crossed 100 mesh sieves respectively, first by Radix Isatidis extract, partly measure microcrystalline Cellulose, partly measure cross-linking sodium carboxymethyl cellulose, half amount low-substituted hydroxypropyl cellulose mixes 5min in wet granulator, with 0.7kg 85% alcohol granulation 15min, gained wet granular is in 60 ~ 70 DEG C of airpillow-dry, 16 mesh sieve granulate, continue to add residue microcrystalline Cellulose again in this granule, cross-linked carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, and sodium lauryl sulphate, micropowder silica gel, lactose, vanillin and aspartame, mix homogeneously in two-dimensional mixing machine, compressing dry granulation, the φ 12mm label making the heavy 0.56g of sheet amounts to 1000.
Film coating procedure is as follows:
(1) preparation of Opadry coating solution
Opadry coating solution 1:
The each component of Opadry coating powder 1 and weight proportion: hypromellose 5cp 65%, red ferric oxide
13%, titanium dioxide 6.5%, PEG400 7%, yellow ferric oxide 1.5%, Ponceau 4R aluminum lake 6%, indigo aluminum color lake 1%; Get Opadry coating powder 1, with 80% ethanol for solvent is mixed with the Opadry coating solution 1 that solid content is 6wt%.
Opadry coating solution 2:
The each component of Opadry coating powder 2 and weight proportion: polyvinyl alcohol 32%, Pulvis Talci 20%, red ferric oxide 25%, Macrogol 4000 10%, Fancy red aluminum lake 6%, soybean phospholipid 1%, Black Rouge 5%, Sunset yellow aluminum lake 1%; Getting Opadry coating powder 2, take purified water as the Opadry coating solution 2 that solvent is mixed with that solid content is 20wt%,
(2) secondary coating
Get above-mentioned label, sieve removes surperficial fine powder, first carries out film coating with described Opadry coating solution 1 according to weightening finish 1.0%, then carry out film coating with described Opadry coating solution 2 according to weightening finish 2.0% in coating pan.
Table 1 Radix Isatidis coated dispersing tablet label raw materials and weight proportion thereof, product inspection result
art for coating comparative examples (embodiment 5 ~ embodiment 7)
As shown in table 2, adopt different coating solution formula and art for coating to carry out film coating to dispersant isatis root tablet label of the present invention (coating element sheet), and to made coated dispersing tablet finished appearance and detect disintegration.
The different coating solution formula of table 2 and art for coating effect comparison
product inspection
The made four batches of Radix Isatidis coated dispersing tablet finished products of Example 1 ~ embodiment 4 (amounting to 4000) are checked as follows:
1. character detects: without bad smell, the sepia of all tablets all in uniformity after removing film coating, no color differnece, mildly bitter flavor.
2. differentiate: get each 2 of above-mentioned four batches of Radix Isatidis coated dispersing tablet every batch, remove coating, porphyrize, add Diluted Alcohol 20ml, supersound process 20 minutes, filter, filtrate evaporate to dryness; Get residue add Diluted Alcohol 2ml make it dissolve, as need testing solution, separately get commercially available Radix Isatidis control medicinal material 1g, add water 50ml, boils 30 minutes, filter, evaporate to dryness, gets residue and adds Diluted Alcohol 20ml.Supersound process 20 minutes, filter, filtrate evaporate to dryness, residue adds Diluted Alcohol 2ml makes dissolving, medical material solution in contrast; Test according to thin layer chromatography (China's coastal port annex VI B), draw each 1 ~ 5 μ l of above-mentioned two kinds of solution, put respectively in same be that the silica gel G thin layer of adhesive is pulled with sodium carboxymethyl cellulose, with n-butyl alcohol-glacial acetic acid-water (volume ratio 19 ︰ 5 ︰ 5) for developing solvent, launch, taking-up is dried, and sprays the ethanol solution of ninhydrin with 1%, is heated to spot development clear; In test sample chromatograph, with on Radix Isatidis control medicinal material chromatograph relevant position, show the speckle of same color.
3. dispersing uniformity test
According to China's coastal port two annex I A, method is tested.The made four batches of each two panels of Radix Isatidis coated dispersing tablet finished product of Example 1 ~ embodiment 4, are placed in the 100ml water of 20 ± 1 DEG C, jolting 3min, the whole disintegrate of visible coated dispersing tablet by No. 2 sieves.
4. test disintegration
According to Chinese Pharmacopoeia version in 2000 annex
a tests.Test result is see table 1.
From table 1 data, Radix Isatidis coated dispersing tablet of the present invention to be significantly shorter than commercially available Radix Isatidis conventional tablet and application number CN200910017928.X and the dispersant isatis root tablet disclosed in application number CN200410025111.4 patent disintegration.
5. Dissolution Rate Testing (dissolving out capability test)
According to China's coastal port two annex Ⅹ C second methods, method is tested.Take water as solvent, with 50 turns/min vibration 50min, get solution appropriate, filter, go filtrate as need testing solution, separately get same sample 10, porphyrize, precision take be equivalent to average sheet heavy 1/10 amount, be placed in 50ml measuring bottle, add water to scale, ultrasonic 50min in warm water, shake up, filter, getting subsequent filtrate solution in contrast, take water as blank, measure the trap of above-mentioned need testing solution and contrast solution in 280nm wavelength place, calculate the dissolution of every sheet with the ratio meter of need testing solution and contrast solution trap.Test result is see table 1.
From table 1 data, the dissolving out capability (dissolution and dissolution rate) of Radix Isatidis coated dispersing tablet of the present invention is much better than commercially available Radix Isatidis conventional tablet, is better than the dispersant isatis root tablet disclosed in application number CN200410025111.4 patent simultaneously.
6. activity substance content measures
According to Chinese Pharmacopoeia 2005 editions one annex VI D, adenosine (Radix Isatidis active substance) content of high performance liquid chromatography to Radix Isatidis coated dispersing tablet measures.
6.1 chromatographic conditions and system suitability
Take octadecylsilane chemically bonded silica as filler, with acetonitrile-water (6:94) for mobile phase, determined wavelength is 260nm.Number of theoretical plate calculates should be not less than 2000 by adenosine peak.
The preparation of 6.2 reference substance solution
Precision takes adenosine reference substance 10mg, puts in 50ml volumetric flask, adds 50% methanol dilution to scale, shakes up; Precision measures 1ml, puts in 10ml measuring bottle, adds 50% methanol dilution to scale, shakes up, and obtains (containing adenosine 20 μ g in every 1ml).
The preparation of 6.3 need testing solutions
Sample thief 20, accurately weighed, removing film-coat, porphyrize, in Erlenmeyer flask, precision adds 50% methanol 20ml to get appropriate (being about equivalent to containing adenosine 0.4mg), close plug, weighed weight, supersound process (frequency 25-60KHZ, power 100-300W) 20 minutes, let cool, more weighed weight, supply the weight of less loss with 50% methanol, shake up, centrifugal, get supernatant, to obtain final product.
6.4 assay method
Accurate absorption reference substance solution and each 10 μ l of need testing solution, inject hplc determination respectively.
With every sheet adenosine (C
10h
13n
5o
4) content meter, measurement result is see table 1.
From table 1 data, dispersant isatis root tablet process stabilizing of the present invention, adenosine content is even, manufacture to adenosine substantially without degrading and loss.
.7. coating stability test
Test condition and result are see table 3.
Table 3 coating stability test result
Comprehensive above-mentioned result of the test can obtain, compared with commercially available Radix Isatidis conventional tablet and existing dispersant isatis root tablet, Radix Isatidis coated dispersing tablet provided by the invention has excellent dispersing uniformity, disintegrate is rapid, dissolving out capability is good, can significantly improve bioavailability, and each batch of unilateral uniform colorless of tablet is poor, long-term placement is without sliver and coating shelling phenomenon, and quality stability is good.
Above-described is only the preferred embodiment of the present invention, the invention is not restricted to above embodiment.Be appreciated that the oher improvements and changes that those skilled in the art directly derive without departing from the spirit and concept in the present invention or associate, all should think and be included within protection scope of the present invention.
Claims (6)
1. a Radix Isatidis coated dispersing tablet, is characterized in that:
Its label is made up of the raw material of following weight portion: Radix Isatidis extract 20 ~ 30 parts, microcrystalline Cellulose 40 ~ 60 parts, low-substituted hydroxypropyl cellulose 10 ~ 15 parts, cross-linking sodium carboxymethyl cellulose 4 ~ 8 parts, sodium lauryl sulphate 0.5 ~ 1 part, micropowder silica gel 0.5 ~ 1 part, lactose 1 ~ 5 part, aromatic 0 ~ 0.5 part, correctives 0 ~ 0.5 part;
Concrete preparation technology is: take by weight ratio after above-mentioned each raw material is crossed 100 mesh sieves respectively; First measure microcrystalline Cellulose, half amount cross-linking sodium carboxymethyl cellulose by Radix Isatidis extract, partly and partly measure low-substituted hydroxypropyl cellulose, mix homogeneously, wet granulation, dry, granulate; Remaining microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose is added again in gained granule, and sodium lauryl sulphate, micropowder silica gel, lactose, aromatic, correctives, mix homogeneously, compressing dry granulation, makes the φ 12mm label of 0.55 ~ 0.59g; Adopt secondary coating method to spray film coating, packaging, obtains coated dispersing tablet finished product;
Described secondary coating method concrete technology is:
(1) preparation of Opadry coating solution
Get Opadry coating powder 1, with 80% ethanol for solvent is mixed with the Opadry coating solution 1 that solid content is 5 ~ 7wt%, described Opadry coating powder 1 is made up of the raw material of following percentage by weight: hypromellose 5cp 60 ~ 70%, red ferric oxide 10 ~ 20%, titanium dioxide 5 ~ 10%, PEG400 5 ~ 10%, yellow ferric oxide 1 ~ 2%, Ponceau 4R aluminum lake 5 ~ 10%, indigo aluminum color lake 1 ~ 2%; Get Opadry coating powder 2, take water as the Opadry coating solution 2 that solvent is mixed with that solid content is 18 ~ 22wt%, described Opadry coating powder 2 is made up of the raw material of following percentage by weight: polyvinyl alcohol 30 ~ 45%, Pulvis Talci 20 ~ 30%, red ferric oxide 10 ~ 20%, Macrogol 4000 10 ~ 15%, Fancy red aluminum lake 5 ~ 10%, soybean phospholipid 1 ~ 2%, Black Rouge 3 ~ 8%, Sunset yellow aluminum lake 1 ~ 2%;
(2) secondary coating
Get described label, first carry out film coating with described Opadry coating solution 1 according to weightening finish 0.5 ~ 1.5%, then carry out film coating with described Opadry coating solution 2 according to weightening finish 1.5 ~ 2.5%.
2. Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that described Radix Isatidis extract preparation technology is: Radix Isatidis decoction pieces is shattered into coarse powder, first add the soak by water 55 ~ 60min of 10 times of weight, cross leaching filtrate, add the soak by water 45 ~ 48min of filtering residue 8 times of weight again, cross leaching filtrate, merge above-mentioned filtrate, being concentrated into relative density in 80 DEG C is 1.05 ~ 1.10, adding 95% ethanol to alcohol content is 60wt%, leave standstill, cold preservation 10 ~ 12h, filter, filtrate recycling ethanol, being concentrated into relative density in 80 DEG C is 1.05 ~ 1.15, spraying dry, obtain Radix Isatidis extract.
3. Radix Isatidis coated dispersing tablet according to claim 1, is characterized in that: described aromatic is selected from vanillin.
4. Radix Isatidis coated dispersing tablet according to claim 1, is characterized in that: described correctives is selected from aspartame or caramel.
5. Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that: described Opadry coating solution 1 solid content is 6wt%, described Opadry coating solution 2 solid content is 20 wt%.
6. Radix Isatidis coated dispersing tablet according to claim 1, is characterized in that: first carry out coating with described Opadry coating solution 1 according to weightening finish 1.0%, then carry out coating with described Opadry coating solution 2 according to weightening finish 2.0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310253372.0A CN103316056B (en) | 2013-06-24 | 2013-06-24 | Radix isatidis coating dispersible tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310253372.0A CN103316056B (en) | 2013-06-24 | 2013-06-24 | Radix isatidis coating dispersible tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103316056A CN103316056A (en) | 2013-09-25 |
| CN103316056B true CN103316056B (en) | 2015-07-08 |
Family
ID=49185289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310253372.0A Active CN103316056B (en) | 2013-06-24 | 2013-06-24 | Radix isatidis coating dispersible tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103316056B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644705B (en) * | 2015-01-26 | 2018-01-23 | 广西世彪药业有限公司 | A kind of preparation method of Radix Isatidis thin membrane coated tablet |
| CN105362242B (en) * | 2015-12-10 | 2019-04-26 | 合肥久诺医药科技有限公司 | A kind of eplerenone dispersible tablet |
| CN107259580B (en) * | 2017-07-17 | 2018-06-19 | 武汉维奥制药有限公司 | The preparation method of one kind of multiple minerals vitamin preparations |
| CN115919948A (en) * | 2022-11-18 | 2023-04-07 | 江苏鹏鹞药业有限公司 | Preparation method of four-ingredient decoction for improving glycometabolism function and learning and memory impairment |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1444890A (en) * | 1974-06-24 | 1976-08-04 | Shinetsu Chemical Co | Coating solid dosage forms |
| CN1157002A (en) * | 1994-07-12 | 1997-08-13 | 伯温德药品服务公司 | Moisture barrier film coating composition, method, and coated products |
| CN1706413A (en) * | 2004-06-11 | 2005-12-14 | 上海中洲天然药物科技开发有限公司 | Dispersant isatis root tablet and its prepn process |
| CN1988891A (en) * | 2004-05-28 | 2007-06-27 | 布里斯托尔-迈尔斯斯奎布公司 | Coated tablet formulation and method |
| CN1993132A (en) * | 2004-07-28 | 2007-07-04 | 大日本住友制药株式会社 | Film coated tablet having plural coats |
| CN101396382A (en) * | 2007-09-27 | 2009-04-01 | 上海市脑血管病防治研究所 | Composite isatis root orally disintegrating tablet and preparation method thereof |
| CN101669982A (en) * | 2009-08-15 | 2010-03-17 | 莱阳市江波制药有限责任公司 | Radix isatidis dispersible tablet and preparation technology thereof |
| CN102218092A (en) * | 2010-04-14 | 2011-10-19 | 北京亚东生物制药有限公司 | Dispersion tablets of traditional Chinese medicine composition |
| CN102228491A (en) * | 2011-06-10 | 2011-11-02 | 中国人民解放军第三○二医院 | Orally rapid disintegrating tablet of isatidis root extract and preparation method thereof |
| CN202173611U (en) * | 2011-05-04 | 2012-03-28 | 烟台大洋制药有限公司 | Novel tablet |
| CN102525992A (en) * | 2012-03-09 | 2012-07-04 | 徐奎 | L-alpha-glycerophosphoryl choline film-coated tablet and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100638315B1 (en) * | 2004-07-23 | 2006-10-25 | 주식회사 대웅제약 | Cored tablets comprising clavulanate and amoxycilin with multiple film coated core layer |
-
2013
- 2013-06-24 CN CN201310253372.0A patent/CN103316056B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1444890A (en) * | 1974-06-24 | 1976-08-04 | Shinetsu Chemical Co | Coating solid dosage forms |
| CN1157002A (en) * | 1994-07-12 | 1997-08-13 | 伯温德药品服务公司 | Moisture barrier film coating composition, method, and coated products |
| CN1988891A (en) * | 2004-05-28 | 2007-06-27 | 布里斯托尔-迈尔斯斯奎布公司 | Coated tablet formulation and method |
| CN1706413A (en) * | 2004-06-11 | 2005-12-14 | 上海中洲天然药物科技开发有限公司 | Dispersant isatis root tablet and its prepn process |
| CN1993132A (en) * | 2004-07-28 | 2007-07-04 | 大日本住友制药株式会社 | Film coated tablet having plural coats |
| CN101396382A (en) * | 2007-09-27 | 2009-04-01 | 上海市脑血管病防治研究所 | Composite isatis root orally disintegrating tablet and preparation method thereof |
| CN101669982A (en) * | 2009-08-15 | 2010-03-17 | 莱阳市江波制药有限责任公司 | Radix isatidis dispersible tablet and preparation technology thereof |
| CN102218092A (en) * | 2010-04-14 | 2011-10-19 | 北京亚东生物制药有限公司 | Dispersion tablets of traditional Chinese medicine composition |
| CN202173611U (en) * | 2011-05-04 | 2012-03-28 | 烟台大洋制药有限公司 | Novel tablet |
| CN102228491A (en) * | 2011-06-10 | 2011-11-02 | 中国人民解放军第三○二医院 | Orally rapid disintegrating tablet of isatidis root extract and preparation method thereof |
| CN102525992A (en) * | 2012-03-09 | 2012-07-04 | 徐奎 | L-alpha-glycerophosphoryl choline film-coated tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| "欧巴代在中药浸膏片薄膜包衣中的应用";陈鸿彬等;《广东药学》;20001231;第10卷(第6期);28-30 * |
| 李静秋等.20000531.《药用辅料——彩色包衣粉应用技术》.化学工业出版社,2000,(第1版), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103316056A (en) | 2013-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103494785B (en) | Montelukast sodium chewable tablet and preparation method thereof | |
| CN103316056B (en) | Radix isatidis coating dispersible tablet and preparation method thereof | |
| CN109946394A (en) | The quality determining method of the HPLC characteristic spectrum and its construction method of the coptis and application, coptis | |
| CN102397342B (en) | Golden buckwheat rhizome extract, pharmaceutical preparation containing golden buckwheat rhizome extract and preparation method thereof | |
| CN104586804B (en) | A kind of preparation method of the Letrozole piece of good stability | |
| CN101653425B (en) | Arbidol hydrochloride medicament composition dispersible tablets and preparation method thereof | |
| CN104998071A (en) | Compound preparation ofherb of dense flower Bulbophyllum and preparation and detection method for said compound preparation | |
| CN104546784B (en) | A kind of penfluridol tablet composition and preparation method thereof | |
| CN101757374B (en) | Medicine for curing burns and scalds and preparation method thereof | |
| CN106860404A (en) | A kind of sildenafil citrate taste masking resin complexes and its application | |
| CN104127510B (en) | Infant heat-clearing granule corrective composition, granule and preparation method of granule | |
| CN103356495B (en) | A kind of Letrozole tablet and preparation method thereof | |
| CN101732406A (en) | Quality detecting method for indigowoad root heat removing pellet | |
| CN101385717B (en) | Solid dispersion containing sofalcone as active ingredient and preparation method thereof | |
| CN101991859A (en) | Beta-cyclodextrin inclusion compound of huperzine A, and preparation method and preparation thereof | |
| CN101708307A (en) | Medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN104274737A (en) | Method for preparing Erbao granules | |
| CN105497722A (en) | Preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules | |
| CN103709329B (en) | A kind of dispersive tablets of Fuyankang for gynecological inflammation pharmaceutical excipient compound and preparation method thereof and application | |
| CN101249119B (en) | Compound compound paracetamol and zincgluconate dispersible tablet and method of preparing the same | |
| CN105055353B (en) | A kind of Entecavir tablet and preparation method thereof | |
| CN103860729B (en) | Five-ester dropping pill and preparation method thereof | |
| CN104337783B (en) | A kind of capecitabine tablet and preparation method thereof | |
| CN103977097A (en) | Yiqing granule preparing method | |
| CN103127007A (en) | Sodium glycididazole composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |