CN103316056A - Radix isatidis coating dispersible tablet and preparation method thereof - Google Patents
Radix isatidis coating dispersible tablet and preparation method thereof Download PDFInfo
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Abstract
The invention provides a radix isatidis coating dispersible tablet and a preparation method thereof. A dispersible tablet core is prepared from the following raw materials in parts by weight: 20-30 parts of extraction of radix isatidis, 40-60 parts of microcrystalline cellulose, 10-15 parts of low substituted hydroxy propyl cellulose, 4-8 parts of croscarmellose sodium, 0.5-1 part of lauryl sodium sulfate, 0.5-1 part of gum acacia, 1-5 parts of lactose, 0-0.5 part of aromatic and 0-0.5 part of corrigent. The method comprises the following steps of carrying out wet granulation, totally mixing, and tabletting to prepare a phi12mm core with the tablet weight of 0.55-0.59g; and carrying out secondary coating to spray a film coating by using an opadry coating solution 1 and an opadry coating solution 2, and packing to obtain a finished product of the dispersible tablet. The radix isatidis coating dispersible tablet has excellent dispersion uniformity, is rapid to disintegrate and good in digesting performance, tablet surfaces of tablets in all the batches are even and have no chromatic aberration; and the tablet has no crack and uncoating phenomena and has good quality stability.
Description
Technical field
The present invention relates to dispersible tablet and preparation technology thereof, be specifically related to Radix Isatidis coated dispersing tablet and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.
Background technology
Radix Isatidis comes from the root of cruciferae isatis and careless Folium Isatidis, bitter in the mouth is cold in nature, it is very widely Chinese crude drug of a kind of application, have the effects such as heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving, detumescence, can improve immunity of organisms and resistance, cure mainly tonsillitis, parotitis, laryngopharynx swelling and pain, infectious hepatitis, infantile measles are had preventive and therapeutic effect.
Present commercially available Radix Isatidis preparation mainly contains the preparations such as oral liquid, granule and conventional tablet, need to add a large amount of correctivess that is used for regulating mouthfeel in oral agents and the granule, but still can't cover the uncomfortable bitterness of Radix Isatidis fully, patient compliance is not high, and one time dose is larger, medication is carried inconvenience often; Common
Radix Isatidis tablet dispersive property is not good, medicine disintegration time long (on average needing more than 5 minutes), Gu onset is slow, and there is larger aberration (sepia and canescence) in tablet appearance, and long-term the placement easily produces sliver, easily dry linting, unilateral coarse, quality stability is poor, in addition, for moistureproof lucifuge and cover bad smell, often conventional tablet is carried out film coating, but be subject to existing art for coating, coating shelling phenomenon ubiquity.
Dispersible tablet means in water the rapidly homodisperse tablet of disintegrate, it is a kind of quick-effective preparation that development in recent years is got up, for the solid preparations such as conventional tablet, capsule, dispersible tablet has taking convenience, disintegrate is rapid, absorption is fast and the bioavailability advantages of higher, can reduce the untoward reaction of medicine, in view of containing the effective ingredient such as fat-soluble stronger organic acid, lignanoid in the Radix Isatidis, at utmost improving bioavailability, Radix Isatidis is prepared into the dispersion sheet very necessary.Application number CN200910017928.X and application number CN200410025111.4 patent all disclose a kind of dispersant isatis root tablet and preparation technology thereof, but be the nude film that bad smell is heavier, mouthfeel is not good, because the Radix Isatidis raw material itself has extremely strong water absorption, the long-term moisture-sensitive of placing, affect mouthfeel and curative effect, in addition, dissolution rate and dissolution still remain further to be improved all above 100s disintegration for above-mentioned dispersible tablet.
Summary of the invention
In view of the foregoing defects the prior art has, the applicant improves on the basis of dispersible tablet prescription, Extraction Technology of Radix Isatidis, film-making technique, coating solution components and art for coating at primary study, and a kind of Radix Isatidis coated dispersing tablet and preparation method thereof is provided.The Radix Isatidis coated dispersing tablet that the method prepares has excellent dispersing uniformity, and disintegrate is rapid, and dissolving out capability is good, the unilateral even no color differnece of each batch tablet, and long-term the placement without sliver and coating shelling phenomenon, quality stability is good.
Technical scheme of the present invention is as follows:
A kind of Radix Isatidis coated dispersing tablet, its label is made by the raw material of following weight portion: 20 ~ 30 parts of Radix Isatidis extracts, 40 ~ 60 parts of microcrystalline Cellulose, 10 ~ 15 parts of low-substituted hydroxypropyl celluloses, 4 ~ 8 parts of cross-linking sodium carboxymethyl celluloses, 0.5 ~ 1 part of sodium lauryl sulphate, 0.5 ~ 1 part of micropowder silica gel, 1 ~ 5 part of lactose, 0 ~ 0.5 part of aromatic, 0 ~ 0.5 part of correctives;
Concrete preparation technology is: take by weighing by weight ratio after above-mentioned each raw material is crossed 100 mesh sieves respectively; First with Radix Isatidis extract, partly measure microcrystalline Cellulose, partly measure cross-linking sodium carboxymethyl cellulose and partly measure low-substituted hydroxypropyl cellulose, mix homogeneously, with 70% above ethanol wet method plasmid, oven dry, granulate; In the gained granule, add remaining microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose again, and sodium lauryl sulphate, micropowder silica gel, lactose, aromatic, correctives, mix homogeneously, tabletting is made the φ 12mm label that sheet weighs 0.55 ~ 0.59g; Adopt the secondary coating method to spray film coating, packing namely gets the coated dispersing tablet finished product;
Described Radix Isatidis extract preparation technology is: the Radix Isatidis decoction pieces is shattered into coarse powder, the decocting that adds first 10 times of weight boils 55 ~ 60min, cross leaching filtrate, the decocting that adds again 8 times of weight of filtering residue boils 45 ~ 48min, cross leaching filtrate, merge above-mentioned filtrate, being concentrated into relative density in 80 ℃ is 1.05 ~ 1.10, adds 95% ethanol to containing the alcohol amount for 60wt%, leaves standstill, cold preservation 10 ~ 12h, filter, filtrate recycling ethanol, being concentrated into relative density in 80 ℃ is 1.05 ~ 1.15, spray drying namely gets Radix Isatidis extract;
Described secondary coating method concrete technology is:
(1) preparation of Opadry coating solution
Get Opadry coating powder 1, be mixed with solid content take 80% ethanol as solvent and be the Opadry coating solution 1 of 5 ~ 7wt%, be preferably 6 wt%, described Opadry coating powder 1 is made by the raw material of following percentage by weight: hypromellose 5cp 60 ~ 70%, red ferric oxide 10 ~ 20%, titanium dioxide 5 ~ 10%, PEG400 5 ~ 10%, yellow ferric oxide 1 ~ 2%, Ponceau 4R aluminum lake 5 ~ 10%, indigo aluminum color lake 1 ~ 2%; Get Opadry coating powder 2, be mixed with solid content take water as solvent and be the Opadry coating solution 2 of 18 ~ 22wt%, be preferably 20 wt%, described Opadry coating powder 2 is made by the raw material of following percentage by weight: polyvinyl alcohol 30 ~ 45%, Pulvis Talci 20 ~ 30%, red ferric oxide 10 ~ 20%, Macrogol 4000 10 ~ 15%, Fancy red aluminum lake 5 ~ 10%, soybean phospholipid 1 ~ 2%, Black Rouge 3 ~ 8%, Sunset yellow aluminum lake 1 ~ 2%;
(2) secondary coating
Get described label, carry out film coating with described Opadry coating solution 1 according to weightening finish 0.5 ~ 1.5% first, carry out film coating with described Opadry coating solution 2 according to weightening finish 1.5 ~ 2.5% again, preferably, carry out film coating with described Opadry coating solution 1 according to weightening finish 1.0% first, carry out film coating with described Opadry coating solution 2 according to weightening finish 2.0% again.
Its further technical scheme is:
Described coated dispersing tablet label is made by the raw material of following weight portion: 23 ~ 27 parts of Radix Isatidis extracts, 48 ~ 52 parts of microcrystalline Cellulose, 12 ~ 16 parts of low-substituted hydroxypropyl celluloses, 3 ~ 7 parts of cross-linking sodium carboxymethyl celluloses, 0.5 ~ 1 part of sodium lauryl sulphate, 0.5 ~ 1 part of micropowder silica gel, 2 ~ 4 parts of lactose, 0.1 ~ 0.3 part of aromatic, 0.1 ~ 0.3 part of correctives.
Described aromatic is selected from vanillin.
Described correctives is selected from aspartame or caramel.
Compare with commercially available Radix Isatidis conventional tablet and existing dispersant isatis root tablet, Radix Isatidis coated dispersing tablet provided by the invention has following advantage:
(1) from Extraction Technology of Radix Isatidis: extract yield of the present invention is high, and extraction process is stable.
(2) from label composition of raw materials and preparation technology: preparation technology's (wet granulation of the present invention, compressing dry granulation etc.) good stability, the unilateral even no color differnece of each batch tablet, adenosine content is even, prove this technique to adenosine isoreactivity material substantially without the degraded and loss, guaranteed the product curative effect.
(3) from coating solution prescription and art for coating: the basic body tool of raw material Baphicacanthus cusia high-hygroscopicity, need fully isolated moisture during preservation, and need fully be dissolved in water after making dispersible tablet and taking, for above-mentioned two specific character contradictions, the invention provides a kind of coating solution prescription (Opadry coating solution 1/ Opadry coating solution 2) and secondary coating method of uniqueness, its principle prediction is as follows: form not too closely sealing coat by high concentration alcohol coating solution 1 on plain sheet surface first, when bag second layer high-moisture coating solution 2, the moisture penetration label of appropriate amount, be unlikely to again to reach the stage of dissolving-recrystallization when playing certain emollescence, the two-layered coating synergism, the more plain sheet of the dissolving out capability of gained dispersible tablet and dispersed homogeneous degree also slightly is improved, disintegration is 50 ~ 70s only, simultaneously, because the buffer action of ground floor coating, the coated tablet outward appearance is good, is difficult for the moisture absorption; After testing, Radix Isatidis coated dispersing tablet of the present invention has excellent dispersing uniformity, and disintegrate is rapid, and dissolving out capability is good, can significantly improve bioavailability, the long-term placement without sliver and coating shelling phenomenon, and quality stability is good; This technique is equally applicable to the preparation of the bibulous coated dispersing tablet of other raw materials.
The specific embodiment
Further describe the present invention below in conjunction with embodiment, in order to more deeply understand the present invention and advantage and effect.
If no special instructions, related each the raw material reagent of following examples is domestic or the Import Analysis net product, and each instrument and equipment that uses is this area conventional equipment.
Radix Isatidis coated dispersing tablet Preparation Example (embodiment 1 ~ embodiment 4)
Radix Isatidis coated dispersing tablet label raw materials and weight proportion thereof are referring to table 1 among embodiment 1 ~ embodiment 4.
Extraction Technology of Radix Isatidis is as follows:
Get commercially available Radix Isatidis decoction pieces 10kg and be ground into coarse powder, the decocting that adds 10 times of weight for the first time boils 60min, crosses leaching filtrate, the decocting that adds for the second time 8 times of weight boils 45min, crosses leaching filtrate, merges above-mentioned filtrate, being concentrated into relative density is 1.10(80 ℃), add 95% ethanol and reach 60wt% to containing the alcohol amount, leave standstill, cold preservation 12h, filter, filtrate recycling ethanol, and to be concentrated into relative density be 1.15(80 ℃), spray drying namely gets Radix Isatidis extract.Detection and Extraction thing yield and adenosine total amount (result is referring to table 1).
Wet granulation, compressing dry granulation preparation technology are as follows:
Each raw material components shown in the table 1 is taken by weighing behind 100 mesh sieves respectively excessively by weight ratio; first with Radix Isatidis extract; partly measure microcrystalline Cellulose; partly measure cross-linking sodium carboxymethyl cellulose; partly measure low-substituted hydroxypropyl cellulose and in wet granulator, mix 5min; with 0.7kg 85% alcohol granulation 15min; the gained wet granular is in 60 ~ 70 ℃ of airpillow-dry; 16 mesh sieve granulate; in this granule, continue to add the residue microcrystalline Cellulose again; cross-linked carboxymethyl cellulose; low-substituted hydroxypropyl cellulose; and sodium lauryl sulphate; micropowder silica gel; lactose; vanillin and aspartame; mix homogeneously in the two-dimensional mixing machine; compressing dry granulation, the φ 12mm label of making the heavy 0.56g of sheet amounts to 1000.
Film coating procedure is as follows:
(1) preparation of Opadry coating solution
Opadry coating solution 1:
Opadry coating powder 1 each component and weight proportion: hypromellose 5cp 65%, red ferric oxide
13%, titanium dioxide 6.5%, PEG400 7%, yellow ferric oxide 1.5%, Ponceau 4R aluminum lake 6%, indigo aluminum color lake 1%; Get Opadry coating powder 1, be mixed with solid content take 80% ethanol as solvent and be the Opadry coating solution 1 of 6wt%.
Opadry coating solution 2:
Opadry coating powder 2 each component and weight proportions: polyvinyl alcohol 32%, Pulvis Talci 20%, red ferric oxide 25%, Macrogol 4000 10%, Fancy red aluminum lake 6%, soybean phospholipid 1%, Black Rouge 5%, Sunset yellow aluminum lake 1%; Get Opadry coating powder 2, be mixed with solid content take purified water as solvent and be the Opadry coating solution 2 of 20wt%,
(2) secondary coating
Get above-mentioned label, sieve removes surperficial fine powder, carries out film coating with described Opadry coating solution 1 according to weightening finish 1.0% first in coating pan, carries out film coating with described Opadry coating solution 2 according to weightening finish 2.0% again.
Table 1 Radix Isatidis coated dispersing tablet label raw materials and weight proportion thereof, the product inspection result
Art for coating control Example (embodiment 5 ~ embodiment 7)
As shown in table 2, adopt different coating solution prescriptions and art for coating that dispersant isatis root tablet label of the present invention (coating element sheet) is carried out film coating, and to made coated dispersing tablet finished product outward appearance and detect disintegration.
The different coating solution prescriptions of table 2 and art for coating effect comparison
Product inspection
Get embodiment 1 ~ embodiment 4 made four batches of Radix Isatidis coated dispersing tablet finished products (amounting to 4000) and carry out following check:
1. character detects: without bad abnormal smells from the patient, remove the sepia that all tablets behind the film coating all are uniformity, no color differnece, mildly bitter flavor.
2. differentiate: get every batch each 2 of above-mentioned four batches of Radix Isatidis coated dispersing tablet, remove coating, porphyrize adds Diluted Alcohol 20ml, and supersound process 20 minutes is filtered the filtrate evaporate to dryness; Get residue and add Diluted Alcohol 2ml and make it dissolving, as need testing solution, other gets commercially available Radix Isatidis control medicinal material 1g, adds water 50ml, boils 30 minutes, filters, and evaporate to dryness is got residue and added Diluted Alcohol 20ml.Supersound process 20 minutes filters, and filtrate evaporate to dryness, residue add Diluted Alcohol 2ml makes dissolving, in contrast medical material solution; Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B), draw each 1～5 μ l of above-mentioned two kinds of solution, put respectively in same silica gel G thin layer take sodium carboxymethyl cellulose as adhesive and pull, take n-butyl alcohol-glacial acetic acid-water (volume ratio 19 ︰ 5 ︰ 5) as developing solvent, launch, taking-up is dried, and sprays the ethanol solution of ninhydrin with 1%, is heated to the speckle colour developing clear; In the test sample chromatograph, with Radix Isatidis control medicinal material chromatograph relevant position on, the speckle of aobvious same color.
3. dispersing uniformity test
Test according to the described method of Chinese Pharmacopoeia version in 2005 two appendix I A.Get each two of embodiment 1 ~ embodiment 4 made four batches of Radix Isatidis coated dispersing tablet finished products, place 20 ± 1 ℃ 100ml water, jolting 3min, the visible whole disintegrates of coated dispersing tablet also can be by No. 2 sieves.
4. test disintegration
According to appendix of Chinese Pharmacopoeia version in 2000
A tests.Test result is referring to table 1.
By table 1 data as can be known, Radix Isatidis coated dispersing tablet of the present invention is significantly shorter than commercially available Radix Isatidis conventional tablet and application number CN200910017928.X and the disclosed dispersant isatis root tablet of application number CN200410025111.4 patent disintegration.
5. Dissolution Rate Testing (dissolving out capability test)
Test according to the described method of Chinese Pharmacopoeia version in 2005 two appendix X C the second method.Take water as solvent, 50 to turn/the min 50min that vibrates, get solution an amount of, filter, go filtrate as need testing solution, other gets 10 of same sample, porphyrize, precision takes by weighing the 1/10 heavy amount of average sheet that is equivalent to, place the 50ml measuring bottle, add water to scale, ultrasonic 50min in warm water, shake up, filter, get in contrast solution of subsequent filtrate, take water as blank, measure the trap of above-mentioned need testing solution and contrast solution in 280nm wavelength place, calculate every dissolution with the ratio meter of need testing solution and contrast solution trap.Test result is referring to table 1.
By table 1 data as can be known, the dissolving out capability of Radix Isatidis coated dispersing tablet of the present invention (dissolution and dissolution rate) is much better than commercially available Radix Isatidis conventional tablet, is better than simultaneously the disclosed dispersant isatis root tablet of application number CN200410025111.4 patent.
6. activity substance content is measured
According to 2005 editions one described high performance liquid chromatography of appendix VI D of Chinese Pharmacopoeia adenosine (Radix Isatidis active substance) content of Radix Isatidis coated dispersing tablet is measured.
6.1 chromatographic condition and system suitability
Take octadecylsilane chemically bonded silica as filler, take acetonitrile-water (6:94) as mobile phase, the detection wavelength is 260nm.Number of theoretical plate calculates by the adenosine peak should be not less than 2000.
6.2 the preparation of reference substance solution
Precision takes by weighing adenosine reference substance 10mg, puts in the 50ml volumetric flask, adds 50% methanol and is diluted to scale, shakes up; Precision measures 1ml, puts in the 10ml measuring bottle, adds 50% methanol and is diluted to scale, shakes up, and namely gets (containing adenosine 20 μ g among every 1ml).
6.3 the preparation of need testing solution
20 of sample thiefs, accurately weighed, remove film-coat, porphyrize is got an amount of (approximately being equivalent to contain adenosine 0.4mg) in Erlenmeyer flask, and precision adds 50% methanol 20ml, close plug, weighed weight, supersound process (frequency 25-60KHZ, power 100-300W) 20 minutes, lets cool, more weighed weight, supply the weight of less loss with 50% methanol, shake up, centrifugal, get supernatant, and get final product.
6.4 assay method
Accurate reference substance solution and each 10 μ l of need testing solution of drawing inject hplc determination respectively.
With every adenosine (C
10H
13N
5O
4) content meter, measurement result is referring to table 1.
By table 1 data as can be known, dispersant isatis root tablet process stabilizing of the present invention, adenosine content is even, manufacture to adenosine substantially without the degraded and loss.
.7. coating stability test
Test condition and result are referring to table 3.
Table 3 coating stability test result
Comprehensive above-mentioned result of the test can get, compare with commercially available Radix Isatidis conventional tablet and existing dispersant isatis root tablet, Radix Isatidis coated dispersing tablet provided by the invention has excellent dispersing uniformity, disintegrate is rapid, dissolving out capability is good, can significantly improve bioavailability, the unilateral even no color differnece of each batch tablet, the long-term placement without sliver and coating shelling phenomenon, quality stability is good.
Above-described only is preferred implementation of the present invention, the invention is not restricted to above embodiment.Be appreciated that other improvement and variation that those skilled in the art directly derive or associate under the prerequisite that does not break away from spirit of the present invention and design, all should think to be included within protection scope of the present invention.
Claims (6)
1. Radix Isatidis coated dispersing tablet is characterized in that:
Its label is made by the raw material of following weight portion: 20 ~ 30 parts of Radix Isatidis extracts, 40 ~ 60 parts of microcrystalline Cellulose, 10 ~ 15 parts of low-substituted hydroxypropyl celluloses, 4 ~ 8 parts of cross-linking sodium carboxymethyl celluloses, 0.5 ~ 1 part of sodium lauryl sulphate, 0.5 ~ 1 part of micropowder silica gel, 1 ~ 5 part of lactose, 0 ~ 0.5 part of aromatic, 0 ~ 0.5 part of correctives;
Concrete preparation technology is: take by weighing by weight ratio after above-mentioned each raw material is crossed 100 mesh sieves respectively; First with Radix Isatidis extract, partly measure microcrystalline Cellulose, partly measure cross-linking sodium carboxymethyl cellulose and partly measure low-substituted hydroxypropyl cellulose, mix homogeneously, wet method plasmid, oven dry, granulate; In the gained granule, add remaining microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose again, and sodium lauryl sulphate, micropowder silica gel, lactose, aromatic, correctives, mix homogeneously, compressing dry granulation is made the φ 12mm label of 0.55 ~ 0.59g; Adopt the secondary coating method to spray film coating, packing namely gets the coated dispersing tablet finished product;
Described Radix Isatidis extract preparation technology is: the Radix Isatidis decoction pieces is shattered into coarse powder, the decocting that adds first 10 times of weight boils 55 ~ 60min, cross leaching filtrate, the decocting that adds again 8 times of weight of filtering residue boils 45 ~ 48min, cross leaching filtrate, merge above-mentioned filtrate, being concentrated into relative density in 80 ℃ is 1.05 ~ 1.10, adds 95% ethanol to containing the alcohol amount for 60wt%, leaves standstill, cold preservation 10 ~ 12h, filter, filtrate recycling ethanol, being concentrated into relative density in 80 ℃ is 1.05 ~ 1.15, spray drying namely gets Radix Isatidis extract;
Described secondary coating method concrete technology is:
(1) preparation of Opadry coating solution
Get Opadry coating powder 1, be mixed with solid content take 80% ethanol as solvent and be the Opadry coating solution 1 of 5 ~ 7wt%, described Opadry coating powder 1 is made by the raw material of following percentage by weight: hypromellose 5cp 60 ~ 70%, red ferric oxide 10 ~ 20%, titanium dioxide 5 ~ 10%, PEG400 5 ~ 10%, yellow ferric oxide 1 ~ 2%, Ponceau 4R aluminum lake 5 ~ 10%, indigo aluminum color lake 1 ~ 2%; Get Opadry coating powder 2, be mixed with solid content take water as solvent and be the Opadry coating solution 2 of 18 ~ 22wt%, described Opadry coating powder 2 is made by the raw material of following percentage by weight: polyvinyl alcohol 30 ~ 45%, Pulvis Talci 20 ~ 30%, red ferric oxide 10 ~ 20%, Macrogol 4000 10 ~ 15%, Fancy red aluminum lake 5 ~ 10%, soybean phospholipid 1 ~ 2%, Black Rouge 3 ~ 8%, Sunset yellow aluminum lake 1 ~ 2%;
(2) secondary coating
Get described label, carry out film coating with described Opadry coating solution 1 according to weightening finish 0.5 ~ 1.5% first, carry out film coating with described Opadry coating solution 2 according to weightening finish 1.5 ~ 2.5% again.
2. described Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that: its label is made by the raw material of following weight portion: 23 ~ 27 parts of Radix Isatidis extracts, 48 ~ 52 parts of microcrystalline Cellulose, 12 ~ 16 parts of low-substituted hydroxypropyl celluloses, 3 ~ 7 parts of cross-linking sodium carboxymethyl celluloses, 0.5 ~ 1 part of sodium lauryl sulphate, 0.5 ~ 1 part of micropowder silica gel, 2 ~ 4 parts of lactose, 0.1 ~ 0.3 part of aromatic, 0.1 ~ 0.3 part of correctives.
3. described Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that: described aromatic is selected from vanillin.
4. described Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that: described correctives is selected from aspartame or caramel.
5. described Radix Isatidis coated dispersing tablet according to claim 1, it is characterized in that: described Opadry coating solution 1 solid content is 6wt%, described Opadry coating solution 2 solid contents are 20 wt%.
6. described Radix Isatidis coated dispersing tablet according to claim 1 is characterized in that: carry out coating with described Opadry coating solution 1 according to weightening finish 1.0% first, 2.0% carry out coating with described Opadry coating solution 2 according to increasing weight again.
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| CN104644705A (en) * | 2015-01-26 | 2015-05-27 | 广西世彪药业有限公司 | Preparation method of isatis root film coated tablets |
| CN105362242A (en) * | 2015-12-10 | 2016-03-02 | 合肥久诺医药科技有限公司 | Eplerenone dispersible tablet |
| CN107259580A (en) * | 2017-07-17 | 2017-10-20 | 武汉维奥制药有限公司 | The preparation method of one kind of multiple mineral matter vitamin preparations |
| CN115919948A (en) * | 2022-11-18 | 2023-04-07 | 江苏鹏鹞药业有限公司 | Preparation method of four-ingredient decoction for improving glycometabolism function and learning and memory impairment |
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| CN104644705A (en) * | 2015-01-26 | 2015-05-27 | 广西世彪药业有限公司 | Preparation method of isatis root film coated tablets |
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| CN105362242B (en) * | 2015-12-10 | 2019-04-26 | 合肥久诺医药科技有限公司 | A kind of eplerenone dispersible tablet |
| CN107259580A (en) * | 2017-07-17 | 2017-10-20 | 武汉维奥制药有限公司 | The preparation method of one kind of multiple mineral matter vitamin preparations |
| CN107259580B (en) * | 2017-07-17 | 2018-06-19 | 武汉维奥制药有限公司 | The preparation method of one kind of multiple minerals vitamin preparations |
| CN115919948A (en) * | 2022-11-18 | 2023-04-07 | 江苏鹏鹞药业有限公司 | Preparation method of four-ingredient decoction for improving glycometabolism function and learning and memory impairment |
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