CN103230386B - Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof - Google Patents

Abstract

The invention relates to clean-free skin and hand micro-emulsion disinfectant agent, and in particular relates to a clean-free skin and hand micro-emulsion disinfectant agent and a preparation method thereof. Under the situation of guaranteeing the effective sterilization, the concentration of ethanol is controlled to be less than 30 percent. Active sterilizing components of the disinfectant agent are chlorhexidine acetate and domiphen bromide, wherein the domiphen bromide has a surface active effect, the ethanol is used as an auxiliary surfactant and a propellant, and a skin and hand micro-emulsion disinfectant solution with the granularity of 1 to 200nm is prepared from injection oil, the surfactant and natural moistening skincare components. The skin and hand micro-emulsion disinfectant solution is practical, simple, high in safety, good in stability and low in thrilling, nano-grade particles form a protection film on a disinfected part, the sterilizing efficacy is high, the added natural moistening skincare component can deeply moisten and whiten the skin, the symptoms such as dry and dry itching caused by utilizing the disinfectant solution with high ethanol content for a long time can be remarkably improved, and an effect for protecting the skin and the hands can be realized.

Description

A kind of disposable skin hands microemulsion disinfectant solution preparation and preparation method thereof

Technical field

The present invention relates to a kind of washing-free antibacterial skin hands microemulsion disinfectant solution, be specifically related to a kind of disposable skin hands microemulsion disinfectant solution preparation and preparation method thereof.This disinfectant solution preparation can kill pathogenic entero becteria, pyococcus, saccharomytes and common bacteria in nosocomial infection, plays Disinfection Effect to skin, has humectant simultaneously and reduces local anaphylaxis, belonging to pharmaceutical preparations technology field.

Background technology

Along with the raising of people's living standard, the sterilization consciousness of resident obtain fast lifting, the demand of sterile products is also being increased.Skin is the first barrier of health and extraneous contact, to come in and go out along with resident the activities such as go on business in public places such as medical institutions, bank, catering trade, public place of entertainment, school, office and carrying out, tourism, skin also becomes the important medium of various pathogen propagation, the infection caused therefrom can affect the healthy of resident, even likely threatens the life of resident.In addition, hand infection is also an important channel of hospital infection, if medical worker's hand cleaning or sterilization after carrying out nursing activity is not thorough, just easily causes pathogen transmission on hand to next patient.Therefore, the cleaning and disinfection often carrying out skin hands plays vital effect for preventing the propagation being carried out pathogen by skin hands, this just need some Disinfection Effects good, act on rapid, easy to use, and the skin hand sanitizing fluid that life-time service is non-stimulated to skin-safe.

Skin hand disinfectant conventional both at home and abroad at present has following two types: a class is the disinfectant such as ethanol, iodine tincture, iodine tincture, because zest is large, lasting effect is not obvious, with obvious twinge during flushing, and produce anaphylactic reaction after having a few peoples to use, be not suitable for the life-time service of skin hands; Another kind of is the compound disinfectant of chlorhexidine acetate and ethanol, but wherein the concentration of ethanol, up to 50%-70%, therefore has strong impulse abnormal smells from the patient, and after using skin hands can dry, produce erythra etc., the protective effect of skin is had much room for improvement.

Microemulsion (microemulsion) is, low viscosity, thermodynamically stable transparent or semitransparent dispersion even with the spontaneous one formed of proper proportion by surfactant, cosurfactant, oil and water, and its size droplet diameter is generally at 10-200nm.Because microemulsion has superpower solvability and good transdermal performance, the surface tension of interfacial film can be reduced, sterilization composition is made to reach higher concentration in local, preservative challenge test simultaneously in American Pharmacopeia also confirms that blank microemulsion has the stable ability antibacterial with energy oneself, all has stronger killing action to bacillus pyocyaneus, staphylococcus aureus etc.Therefore, microemulsion is utilized to be a kind of dosage form of disposable skin hand sanitizing fluid of great potential.

Summary of the invention

The object of the invention is for overcoming above-mentioned the deficiencies in the prior art part, a kind of disposable skin hands microemulsion disinfectant solution preparation and preparation method thereof is provided, and when ensureing effective sterilizing, the concentration of ethanol is controlled below 30%.The present invention's composition that effectively sterilizes is chlorhexidine acetate and domiphen bromide, wherein domiphen bromide is with surface-active action, ethanol is as cosurfactant and volatilizer simultaneously, adopt oil for injection, surfactant and natural moisture preserving skin protection composition, be prepared into the skin hands microemulsion disinfectant solution that particle diameter is 1-200nm.This skin hands microemulsion disinfectant solution practicality is simple and direct, safety is high, good stability, zest are low; nano level particle assembles formation protecting film at sterilization position; fungicidal effectiveness is strong; the natural moisture preserving skin protection composition energy deep layer of adding nourishes skin whitening; the drying that the disinfectant solution that significantly can improve life-time service height ethanol content produces, the dry symptom such as to itch, have the effect of protection skin hands.

The present invention realizes with following technical scheme: a kind of disposable skin hands microemulsion disinfectant solution preparation, and it is characterized in that, it comprises the component of following each weight/volume percent (w/v):

All the other are pH adjusting agent and distilled water.

Described oil for injection is selected from the fatty glyceride of medium chain between soybean oil, chain length C6 ~ C12 as Arlacel80, Arlacel86, Captex200(oil), one or more in Myvacet (oil), median chain triglyceride oil; Described emulsifying agent is selected from one or more in injection PLURONICS F87 (F68), polyoxyethylene castor oil (Cremophor ELP), polyoxyethylene hydrogenated Oleum Ricini (Cremophor RH), polyethyleneglycol-12-hydroxy stearin (Solutol HS 15); Described natural moisture preserving skin protection composition is one or more in resveratrol, tea polyphenols, grape polyphenols, Radix Ginseng extractive solution, quercimentin and Folium Bambosae flavone; PH adjusting agent is selected from the one in sodium hydroxide solution, hydrochloric acid and salt thereof.

Described pH adjusting agent is sodium hydroxide solution, and concentration is 0.001M-5.0M; Or be hydrochloric acid solution, concentration is 0.001M-5.0M.

Described a kind of disposable skin hands microemulsion disinfectant solution is size droplet diameter be 10nm ~ 200nm is the clarification of isotropy, transparent liquid, and have light blue opalescence, possess Tyndall phenomenon, pH is 5.5 ~ 7.0.

Prepare a method for a kind of disposable skin hands microemulsion disinfectant solution according to claim 1, it is characterized in that comprising the following steps:

(1), after the chlorhexidine acetate of recipe quantity, domiphen bromide and oil for injection heated and stirred is even, add the surfactant dissolving natural moisture preserving skin protection composition, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol and the ethanol of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase;

(2) under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 10min-60min, obtain microemulsion; After microemulsion is cooled to room temperature, adjusts pH to be 5.5 ~ 7.0, preserve under room temperature.

Detailed description of the invention

Below by embodiment, the present invention will be further described, but be not construed as limiting the invention

Embodiment 1,

By the chlorhexidine acetate 4.5g of recipe quantity, domiphen bromide 0.2g and median chain triglyceride oil 12.0g heated and stirred evenly after, add surfactant (Cremophor ELP) 160.0g dissolving ginsenoside extract 13.0g and quercimentin 8.0g, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol 10.0g and the ethanol 100.0g of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase; Under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 60min, obtain microemulsion 1.0L; After microemulsion is cooled to room temperature, adjusts pH to be 6.60, preserve under room temperature.

Embodiment 2,

By the chlorhexidine acetate 3.5g of recipe quantity, domiphen bromide 0.6g and Arlacel86 14.0g heated and stirred evenly after, add surfactant (polyethyleneglycol-12-hydroxy stearin) 180.0g dissolving resveratrol 6.0g and quercimentin 10.0g, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol 30.0g and the ethanol 250.0g of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase; Under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 60min, obtain microemulsion 1.0L; After microemulsion is cooled to room temperature, adjusts pH to be 6.20, preserve under room temperature.

Embodiment 3,

By the chlorhexidine acetate 1.5g of recipe quantity, domiphen bromide 1.0g and median chain triglyceride oil 9.0g heated and stirred evenly after, add surfactant (PLURONICS F87) 120.0g dissolving grape polyphenols 10.2g and quercimentin 5.0g, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol 40.0g and the ethanol 200.0g of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase; Under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 60min, obtain microemulsion 1.0L; After microemulsion is cooled to room temperature, adjusts pH to be 5.80, preserve under room temperature.

Embodiment 4,

By the chlorhexidine acetate 2.5g of recipe quantity, domiphen bromide 0.8g and median chain triglyceride oil 10.5g heated and stirred evenly after, add surfactant (Cremophor ELP) 130.0g dissolving Folium Bambosae flavone 4.0g and quercimentin 5.0g, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol 35.0g and the ethanol 220.0g of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase; Under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 60min, obtain microemulsion 1.0L; After microemulsion is cooled to room temperature, adjusts pH to be 6.50, preserve under room temperature.

Embodiment 5,

By the chlorhexidine acetate 1.5g of recipe quantity, domiphen bromide 0.9g and median chain triglyceride oil 22.0g heated and stirred evenly after, add surfactant (polyethyleneglycol-12-hydroxy stearin) 170.0g dissolving tea polyphenols 3.5g and quercimentin 4.0g, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol 50.0g and the ethanol 230.0g of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase; Under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 60min, obtain microemulsion 1.0L; After microemulsion is cooled to room temperature, adjusts pH to be 6.00, preserve under room temperature.

Claims (4)

1. a disposable skin hands microemulsion disinfectant solution, is characterized in that, it comprises the component of following each weight/volume percent (grams per milliliter):

Described oil for injection is selected from soybean oil or Captex200, Myvacet, chain length C ₆-C ₁₂between median chain triglyceride oil fatty glyceride in one or more;

Described emulsifying agent is selected from one or more in injection PLURONICS F87, Cremophor ELP, Cremophor RH, Solutol HS 15; Natural moisture preserving skin protection composition is one or more in resveratrol, tea polyphenols, grape polyphenols, Radix Ginseng extractive solution, quercimentin and Folium Bambosae flavone; PH adjusting agent is selected from the one in sodium hydroxide solution, hydrochloric acid and salt thereof.

2. one according to claim 1 disposable skin hands microemulsion disinfectant solution, it is characterized in that: described pH adjusting agent is sodium hydroxide solution, concentration is 0.001M-5.0M; Or be hydrochloric acid solution, concentration is 0.001M-5.0M.

3. one according to claim 1 disposable skin hands microemulsion disinfectant solution, it is characterized in that: size droplet diameter is 10nm ~ 200nm, the clarification in isotropy, transparent liquid, have light blue opalescence, possess Tyndall phenomenon, and pH is 5.5 ~ 7.0.

4. prepare a method for a kind of disposable skin hands microemulsion disinfectant solution according to claim 1, it is characterized in that comprising the following steps:

(1), after the chlorhexidine acetate of recipe quantity, domiphen bromide and oil for injection heated and stirred is even, add the emulsifying agent dissolving natural moisture preserving skin protection composition, rapid stirring is even, obtains oil phase; In the distilled water of recipe quantity, add glycerol and the ethanol of recipe quantity, be heated to the temperature identical with oil phase, obtain aqueous phase;

(2) under the condition of temperature constant magnetic stirring, by 20 DEG C-40 DEG C mixing in hermetic container of aqueous phase, oil phase, stir 10min-60min, obtain microemulsion; After microemulsion is cooled to room temperature, adjusts pH to be 5.5 ~ 7.0, preserve under room temperature.