KR20160079459A - Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component - Google Patents
Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component Download PDFInfo
- Publication number
- KR20160079459A KR20160079459A KR1020140190832A KR20140190832A KR20160079459A KR 20160079459 A KR20160079459 A KR 20160079459A KR 1020140190832 A KR1020140190832 A KR 1020140190832A KR 20140190832 A KR20140190832 A KR 20140190832A KR 20160079459 A KR20160079459 A KR 20160079459A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- green tea
- cleaning
- tea extract
- virus
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Detergent Compositions (AREA)
Abstract
The present invention relates to a composition for cleaning or disinfecting, comprising a green tea extract. The composition for cleaning or disinfecting according to the present invention has an antiviral activity by containing green tea extract as an active ingredient, and comprises an antioxidant and a stabilizer, The antiviral activity and the persistence of the extract are improved, and shelf life is increased. Therefore, it is easy to commercialize, and the antiviral activity and the antibacterial activity including various natural additives and porous beads are high, It is a multi-purpose composition that can be used as a disinfectant, a human body detergent, a bottle disinfectant, or an animal disinfectant, and can be used easily and quickly for various respiratory diseases having a high vaccine dependency and limited effect of existing therapeutic agents.
Description
The present invention relates to a composition for cleaning or disinfecting which has antiviral activity and long-term storage stability.
Influenza is a type of respiratory disease virus that is spread not only to humans but also to various kinds of animals as well as livestock such as pigs, chickens, ducks or horses.
In particular, in 2009, pandemic highly pathogenic viruses such as novel swine-origin influenza A (H1N1) appeared, resulting in massive casualties and massive economic losses.
The above-mentioned influenza virus belongs to Orthomyxoviridae and has eight negative strand RNA fragments of PB2, PB1, PA, HA, NP, NA, M and NS.
Of the above negative strand RNA fragments, HA is a gene encoding hemagglutinin (hereinafter referred to as "HA") which is a transcriptional envelope protein, and is an antigen of virus surface which is involved in adhesion to influenza virus mammalian cells NA is a gene encoding neuraminidase (hereinafter referred to as "NA "), plays an important role when a virus enters or leaves a host cell, And the virus is transformed through the process of antigenic feces or antigen urine. Therefore, the treatment is not easy.
The above-described influenza viruses generally exhibit various symptoms and severity according to the subtypes prevalent in winter, and there are various viruses ranging from those having no pathogenicity to those having a high mortality rate of 60%. Generally, Pneumonia, and cardiopulmonary complications, resulting in a high mortality rate. The highly pathogenic avian influenza virus is classified as a Type 1 infectious disease in Korea and is classified as List A in the International Bureau of OIE (OIE).
In 2009, the case of H1N1 influenza was lower than that of avian influenza, but it was highly contagious, causing economic and social problems.
The above-mentioned avian influenza virus is a common infectious virus, and the main propagation factor is contaminated feces, and it can be spread by droplet, air, water and the like. In addition, the avian influenza virus may infect humans through intermediate hosts such as pigs and chickens. In the middle host, the avian influenza virus may cause gene mutation or recombination with other viruses, It spreads to people through respiratory infections and causes flu.
However, the development of effective preventive vaccines against newly emerging influenza viruses is insufficient and the limitation of current therapeutic agents remains a problem.
Examples include ion channel inhibitors such as Amantadine and Rimantadine, Oseltamivir, a neuraminidase (NA) inhibitor, which have been developed in the past, Zanamivir et al. Have already reported mutagenic strains that are resistant to the development of new antiviral interventions.
Recently, it has been reported that personal hygiene habits such as wearing masks and hand hygiene can significantly suppress the spread of viruses, and it is known to be an effective method for pandemic influenza, such as pandemic influenza, because it quickly and easily blocks virus transmission .
Accordingly, after the H1N1 influenza became popular, various hand disinfectants and hand cleansers appeared on the market like pussy. Currently, the KFDA classifies hand sanitizer as quasi-drug and hand cleanser as cosmetics.
A common hand sanitizer currently marketed is one that uses one of ethanol, isopropanol, benzalkonium chloride, cresol, hydrogen peroxide as a main component and protects skin damage caused by alcohol. It is manufactured using propylene glycol, glycerin, tocopherol and the like , And the gel type containing alcohol in a ratio of 60 to 70% is most common as a hand disinfectant that does not use water. The hand-cleansing agent is used as an auxiliary to hand-cleansing as a cosmetic product, and is generally hand-made water-based hand-washing, hand wash, and hand washing soap.
The above-mentioned hand cleaner and hand sanitizer usually have a shelf life of 2 to 3 years, but it is recommended to use it within 6 months after opening. It is not easy to preserve and ethanol, isopropanol, benzalkonium chloride, cresol The use of synthetic chemicals such as water, hydrogen peroxide, and the like has caused skin problems such as allergies and skin troubles.
Accordingly, studies on natural detergents or disinfectants using natural substances have been actively conducted, and in particular, the number of research papers on various physiological activities of green tea having antiviral activity has been rapidly increasing, and in particular, influenza viruses, Various studies have been conducted on a method for producing a detergent and a disinfectant by using an extract of green tea having an antiviral activity against retroviruses such as retroviruses, fstivinaviruses and herpes viruses.
However, the detergents and disinfectants using the green tea extracts described above are made of natural materials and have difficulty in storage due to short shelf life due to difficulty in storage and distribution due to difficulty in mass production. In order to increase shelf life, There is a problem in that it is limited in use to a person having skin allergy due to a synthetic chemical ingredient contained in the manufactured detergent and disinfectant.
Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made in order to solve the problems of the prior art as described above. It is an object of the present invention to provide an antioxidant and a stabilizer to green tea extract to improve the stability of green tea extract and the shelf- And to provide a composition for cleaning or disinfecting which is improved in durability.
Another object of the present invention is to provide a technique for preventing the spread of viruses and bacteria by using the composition for cleaning or disinfection with improved quality life and for the purpose of disinfection and multi-purpose cleaning.
It is another object of the present invention to provide a cleaning and disinfecting composition which is capable of exhibiting antiviral activity and antimicrobial activity equal to or better than conventional hand and multi-use cleaning agents by utilizing natural ingredients such as green tea extract as an active ingredient of a cleaning or disinfecting composition, And to provide a composition for cleaning or disinfecting which is environmentally friendly and less harmful to human health.
In order to accomplish the above object, the present invention provides a composition for cleaning or disinfection, which comprises an extract of green tea and has an antiviral activity.
In addition, the composition for cleaning or disinfecting is characterized in that the green tea extract is contained in an amount of 20% or less based on the total weight of the composition.
In addition, the composition for cleaning or disinfecting is characterized by having antiviral activity against enveloped virus.
In addition, the coat virus is characterized by being an influenza virus, a retrovirus, an epstein-barr virus or a herpes simplex virus.
In addition, the green tea extract may contain at least one selected from the group consisting of catechin, epicatechin, epigallocatechin (EGC), epicatechin gallate (ECG), epigallocatechin gallate (EGCG) and flavonoid derivatives thereof.
The composition for cleaning or disinfecting further comprises an antioxidant and a stabilizer, and is characterized by excellent long-term storage stability.
The antioxidant is at least one compound selected from the group consisting of tocopherol, ascorbic acid, ascorbic acid derivatives, gallic acid, quercetin, flavonol, flavonoid, catechol, ethoxyquin and lignan glycosides, And 1.5% or less.
The stabilizer may be at least one selected from the group consisting of β-cyclodextrin, citric acid, magnesium chloride, MgCl 2 , ethylenediaminetetraacetic acid (EDTA salt), dibutylhydroxy toluene (BHT) , And is contained in an amount of 1% or less based on the total weight of the composition.
The cleaning or disinfecting composition may further comprise at least one member selected from the group consisting of isopropyl alcohol, ethanol, n-propanol, t-butanol, 2-butanol, pentanol, hexanol and povidone- .
The cleaning or disinfecting composition may further include a porous bead, a natural fragrance or a natural additive.
The composition for cleaning or disinfecting according to the present invention not only increases personal hygiene easily and quickly for various existing respiratory diseases with high vaccine dependency and limited therapeutic effect by containing green tea extract having antiviral activity as an effective ingredient This spread of viral diseases can be greatly reduced, and it can be used for various purposes such as disinfection and washing for personal use, business use, hospital use or shaft use, and especially for direct disinfection of animals, farmers, farmhouses and livestock farmers Do.
Further, the composition for cleaning or disinfecting according to the present invention has an increased shelf life by treating an antioxidant and a stabilizer to a green tea component, thereby facilitating commercialization. In addition, by using green tea, which is an eco-friendly material, people with skin diseases can easily use it and can promote the domestic green tea industry that has already reached internationalization level.
FIG. 1 shows the antiviral activity of EGCG, a major component of green tea extract, as a result of plaque inhibition experiments.
Fig. 2 is a graph showing the result of the plaque formation experiment of Experimental Example 2. Fig.
Hereinafter, the present invention will be described in detail.
The composition for cleaning or disinfecting according to the present invention is characterized by having an antiviral activity including an green tea extract as an active ingredient.
In order to prepare the above green tea extract, green tea is heated or fermented by using non-fermented green tea leaves, green tea stems, and green tea seeds to destroy the oxidizing enzyme and extract the green tea extract. It is preferable that the composition is maintained as it is.
For this purpose, green tea leaves, green tea stalks and green tea seeds were sampled, steamed and steamed, heated to 100 to 300 ° C so as to increase the active ingredient content of green tea, dried and finely pulverized with fine powder to obtain green tea powder And extracted with hot water, followed by concentration to prepare green tea extract.
The green tea extract prepared by fermenting the green tea powder by fermenting the green tea powder by fermenting the raw material such as molasses or sweet potato and extracting it using an extraction solvent may be used. Alternatively, a green tea extract prepared by distillation extraction . The green tea extract can be prepared by various known methods.
The green tea extract prepared as described above contains catechin, epicatechin, epigallocatechin (EGC), epicatechin gallate (ECG), epigallocatechin gallate, EGCG), and flavonoid derivatives. When the composition for cleaning or disinfecting according to the present invention is used, it exhibits an effect of removing more than 90% of the virus to maintain a clean state.
In addition, the antiviral active ingredient contained in the above-mentioned green tea extract may be used as an antiviral agent such as an influenza virus, a retrovirus, an epstein-barr virus or a herpes simplex virus The present invention relates to a method for preparing a green tea extract, comprising the steps of: (a) preparing a green tea extract having an antiretroviral activity, Or a composition for disinfecting can be prepared.
The natural water may be selected from the group consisting of sodium (Na), calcium (Ca), magnesium (Mg), magnesium (Mg) and the like, which are effective for controlling osmotic pressure and physiological action, It is possible to improve the physical properties of the composition for cleaning or disinfection by containing a large amount of mineral components such as potassium (K), strontium (Sr), lithium (Li), chlorine ion (C1), zinc (Zn) .
The composition for cleaning or disinfecting according to the present invention can be prepared by mixing a natural preservative for the purpose of improving the stability of long-term storage.
The natural antiseptics include, for example, antioxidants. In the present invention, the antioxidant is a natural antioxidant, which is an active ingredient contained in a composition for cleaning or disinfecting, The absorption of the radicals leads to physical and chemical changes resulting in oxidation, or oxidation due to the complex reaction due to temperature changes, or homolytic cleavage of water molecules by light irradiation Oxidation reaction may occur due to a very strong active radical complex reaction formed by the oxidation of the antioxidant and the oxidation of the antioxidant, It acts to prevent oxidation of other substances by being oxidized before other substances. Kinds of alcohols, aldehydes, an effect to prevent oxidation products such as ketones, maintains the quality for the cleaning or disinfecting composition according to the invention and to increase the shelf life.
As such antioxidants, it is preferable to use tocopherol, ascorbic acid, ascorbyl palmitate, gallic acid, quercetin, flavonol, flavonoid, ethoxyquin, lignan glycoside and mixtures thereof.
In addition to the antioxidant, a stabilizer may be further added to increase the antiviral activity and persistence of the green tea extract and to further improve the long-term storage stability of the composition. In particular, And thus preventing the detachment and thus improving the stability of the composition for disinfection or cleaning according to the present invention.
Examples of such stabilizers include β-cyclodextrin, citric acid, magnesium chloride, MgCl 2 , ethylene diamine tertracetic acid (EDTA salt), and dibutyl hydroxy toluene (BHT ) As a representative example.
Meanwhile, it is preferable that the antioxidant is contained in an amount of 1.5% by weight or less based on the total weight of the composition for disinfection or cleaning according to the present invention, and the stabilizer is contained in an amount of 1% by weight or less based on the total weight of the composition for disinfection or cleaning according to the present invention Do.
The antioxidant may further comprise a herb or herbal medicine extract having antimicrobial activity as a natural preservative other than the antioxidant. Examples of the natural antiseptic include gum rosin containing an inulin component and ginseng containing a saponin component These natural preservatives can inhibit the growth of microorganisms in the composition and can be configured to further increase the shelf life of the composition for cleaning or disinfection.
In addition, the composition for disinfection or cleaning according to the present invention may further contain, in addition to the above-described green tea extract as the main cleansing component, an additional sterilizing and cleaning component such as isopropyl alcohol, ethanol, n-propanol, t-butanol, Novolan, and povidone-iodo. ≪ / RTI >
Further, the composition for disinfection or cleaning according to the present invention may further include a porous bead, thereby further improving the physical properties of the composition.
Since the porous beads are typical examples of the chitosan, the low molecular weight chitosan has antimicrobial and antifungal activity as a natural material. Therefore, it can act as a preservative in the prepared composition, And has excellent biocompatibility to maintain skin moisturization.
In addition, the composition for disinfection or cleaning according to the present invention may further include a natural fragrance to impart fragrance if necessary.
Examples of the natural fragrances include rosemary, lavender, rose, lavandin, lemon, rosewood, mandarin, jasmine, basil, ) Obtained from plants such as, for example, tomatoes, alfalfa, marigold, sandalwood, bergamot, citronella, orange, eucalyptus, chamomile, palmarosa or majoram. Extracts or essential oils may be used.
These natural fragrances each have antimicrobial activity against specific microorganisms, and when they are added to impart fragrance in the preparation of compositions for antiviral cleansing or disinfection, they exhibit an effect of simultaneously elevating the antibacterial ability and can be preferably used.
In addition, the composition for disinfection or cleaning according to the present invention can be configured to further improve the physical properties of a composition for cleaning or disinfection prepared by adding a natural additive including a natural thickener, a natural pH-adjusting substance and the like.
The natural thickener may be natural polymers such as starch, xanthan gum, locust bean gum, carrageenan, pectin gelatin and the like as an increasing agent for stabilizing and stabilizing the foamed composition for cleaning or disinfection. It is preferably contained in an amount of 0.0001 to 10% by weight, and if it is less than 0.0001% by weight, the effect of scaling up is insignificant, and if it exceeds 10% by weight, the scaling agent is unstable in dispersion.
The composition for disinfecting or cleaning according to the present invention may be prepared by using fruit acids such as grape seed extract, lemon juice, vinegar, and malic acid, which are natural pH controlling substances, or citric acid Can be used to lower the pH, and the pH can be increased by using potassium hydroxide, sodium hydroxide, or the like.
In addition, it is preferable to configure the pH of the natural pH-adjusting substance to be 0.01 to 0.5% by weight based on the total weight of the composition. If the pH is less than 0.01% by weight, On the contrary, when the amount is more than 0.5% by weight, the acidity or basicity becomes excessively high, so that the function of the composition for disinfection or cleaning deteriorates. Therefore, the total use of the composition for disinfection or cleaning according to the present invention It is preferable to have a weak acidity less than 7 and less than 7 in order to maintain a healthy skin.
The composition for disinfection or cleaning according to the present invention having the above composition can be prepared by formulating into a liquid, gel, emulsion or aerosol form. Further, a natural addition product which is subjected to a saponification reaction is further mixed to obtain a solid To this end, a saponification reaction may be induced so that a soap and natural glycerin are formed by further adding a natural oil and reacting with potassium hydroxide to prepare a solid form.
When it is prepared in the form of a liquid, a gel or an emulsion, it can be produced in a concentration that can be practically used, but it can be made into a concentrated type concentrated so that it can be used in a diluted state. For long- To be used in the form of a solid powder.
The composition for disinfection or cleaning according to the present invention may be prepared by (a) preparing a green tea extract using green tea leaves, green tea stalks and green tea seeds, (b) (C) preparing a composition for cleaning or disinfecting by adjusting the pH of the natural detergent composition to prepare a composition for disinfection or cleaning, A composition can be prepared.
The disinfection of a hospital room, which is treating patients with viral diseases, and the disinfection of the hands, the human body, clothing and medical devices of health workers are not straightforward. Generally, disinfecting using strong acids, strong bases or chlorine disinfectants, the aforementioned disinfectants effectively kill the virus, but are limited in practical use.
The use of the composition for disinfection or cleaning according to the present invention as a disinfectant makes it possible to disinfect an animal or disinfect the animals, farm animals and farmers directly.
When the composition for disinfection or cleaning according to the present invention is used, it can be used for direct disinfection or cleaning since it is not harmful to human health or environment, and can be used for disinfecting or cleaning, and can remove 90% or more of infectious coat virus existing on skin , Can exhibit antibacterial activity and can effectively remove germs and harmful substances, and has anti-viral activity even after a long period of time after its manufacture including antioxidants, so that it can be applied to the production of various types of natural detergents and disinfectants.
Hereinafter, the present invention will be described in more detail with reference to preferred embodiments.
The embodiments presented are only a concrete example of the present invention and are not provided for the purpose of limiting the scope of the present invention.
≪ Example 1 >
In order to prepare the composition for disinfection or cleaning according to the present invention of Example 1, a green tea extract was prepared using green tea leaves, green tea stems, and green tea seeds.
To prepare green tea extract, hot water extraction method was used. The green tea leaves, green tea stalks and green tea seeds were mixed with steam and cooled. The green tea was then dried in a container heated to 200 to 300 캜, dried, (W / v) of the green tea powder was immersed in water at 70 to 90 ° C and allowed to stand for 12 to 24 hours. Then, the green tea extract was filtered and concentrated under reduced pressure to give green tea The extract was prepared.
1 to 10 parts by weight of ascorbic acid as an antioxidant was added to the green tea extract to prepare a cleaning or disinfecting composition.
<Experimental Example 1>
In Experimental Example 1, plaque formation inhibition experiments were conducted to examine the effect of green tea extract on the activity of influenza virus.
To this end, MDCK (Madin-Darby, canine kidney, ATCC, USA) was added to the MEM medium (Menimum Essential Medium: GIBCO Invitrogen Coporation, USA) containing Fetal Bovine Serum (FBS: GIBCO Invitrogen Coporation, USA) USA) were inoculated at a concentration of 1.5 × 10 5 cells / ml and cultured in a 6-well plate at 37 ° C. in a 5% CO 2 incubator.
A / Korea / 01/09 (H1N1) and A / Aquatic Bird / w81 / 05 (H5N2) were infected with 200 PFU (Plaque Forming Unit) in the MDCK cell line ) / Ml. ≪ / RTI >
After the infection treatment, the virus solution treated with cells was removed and the cell line was washed with 1 ml / well of PBS (Photometric Phosphate Bufferd Saline) buffer.
The green tea extract was diluted twice to a final concentration of 100 μg / mL to 6.25 μg / mL, and then diluted with an overlay medium (1% agarose, DMEM containing trypsin enzyme at a concentration of 10 μg / mL Modified Eagle's Medium: GIBCO Invitrogen Coporation, USA) medium], and an overlay medium was used as a control. The overlay medium was applied to the cells infected with influenza virus at 3 ml / well. After 15 minutes, the overlay medium was solidified and incubated for 72 hours in an incubator maintained at 37 ° C and 5% CO 2 .
As a result, the plaque was formed during the 72 hours, and plaque formation was inhibited in the experimental group to which the green tea extract was added. 1, which is a photograph showing the results of the plaque inhibition experiment according to Experimental Example 1, it was confirmed that plaque formation of the influenza virus was inhibited when treated with EGCG, which is a main component of green tea extract, As the concentration of EGCG used increased, plaque formation was inhibited. However, it was confirmed that plaque formation was not inhibited in the case of the control group.
After each number of plaques was repaired by the plaque inhibition experiment, plaque formation inhibition ability of the influenza virus by the green tea extract was determined by the ratio of the plaque number of the control group and the plaque number of the test group.
<Experimental Example 2>
In the present Experimental Example 2 In order to confirm the virus removal capability of the green tea extract artificial skin cells, neo bonus ® E was added MEM medium according to the manufacturer's protocol using the (Tego Science, South Korea) and 24 hours at 37 ℃ CO 2 incubator After incubation, low-temperature adaptive X-31 virus was spotted by 5 x 10 4 PFU, washed with green tea extract, and the virus removal / inactivation effect by this washing effect was verified by plaque assay in MDCK cell line. More specifically, the cells were washed with phosphate buffered saline (PBS) after culture and the virus was spotted by 5 x 10 4 PFU. Then, the cells were cultured in a 37 ° C CO 2 incubator for 24 hours and washed with 100 μg / mL and 200 μg / mL of green tea extract or virus-infected artificial cells, respectively. For reference, the virus titer was confirmed by the plaque formation experiment performed in Example 1 with the washing solution to confirm the virus removal ability of the green tea extract.
Fig. 2 is a graph showing the result of the plaque formation experiment of Experimental Example 2. Fig.
As shown in FIG. 2, plaque was not formed in the virus-infected artificial cells in the medium washed with the green tea extract, and it was confirmed that the green tea extract had an excellent effect on the virus removal.
<Experimental Example 3>
In Experimental Example 3, ascorbic acid, an antioxidant, was added to green tea extract to increase the shelf life of green tea extract for use as a hand cleaner or a disinfectant. The antiviral activity of green tea extract was increased or decreased.
To this end, various concentrations of ascorbic acid were added to 100 ㎍ / mL of green tea extract and stored at room temperature for 2 months. At this time, plaque formation inhibition experiment was performed on 200 PFU of A / Korea / 01/09 (H1N1) virus once every 5 days, and the change in the shelf life of green tea extract was confirmed by antioxidant.
To confirm the increase of shelf life of antioxidants and stabilizers, stabilizers were added to various concentrations of green tea extract containing ascorbic acid and stored at room temperature for 2 months. In addition, a plaque formation inhibition experiment with 200 PFU of A / Korea / 01/09 (H1N1) virus was conducted once every five days to confirm the change in the shelf life of green tea extract by antioxidants and stabilizers.
As a result of measuring the change of the shelf life of green tea extract, the shelf life of the green tea extract was increased and it was confirmed that the antiviral activity of the green tea extract was maintained even after more than 2 months.
Claims (10)
Wherein the green tea extract is contained in an amount of 20% or less based on the total weight of the composition.
A composition for cleaning or disinfection, characterized by having an antiviral activity against enveloped virus.
Wherein the coating virus is an influenza virus, a retrovirus, an epstein-barr virus or a herpes simplex virus.
The green tea extract contains at least one of catechin, epicatechin, epigallocatechin (EGC), epicatechin gallate (ECG), epigallocatechin gallate (EGCG) and flavonoid ) Derivatives. ≪ Desc / Clms Page number 24 >
Wherein the composition further comprises an antioxidant and a stabilizer, and is excellent in long-term storage stability.
Wherein the antioxidant is at least one compound selected from the group consisting of tocopherol, ascorbic acid, ascorbic acid derivatives, gallic acid, quercetin, flavonol, flavonoid, catechol, ethoxyquin and lignan glycosides, % Or less of the total amount of the composition for cleaning or disinfection.
The stabilizer may be selected from the group consisting of β-cyclodextrin, citric acid, magnesium chloride, MgCl 2 , ethylenediaminetetraacetic acid (EDTA salt), and dibutyl hydroxy toluene (BHT) Wherein the composition is contained in an amount of 1% or less based on the total weight of the composition.
A composition for cleaning or disinfection, which further comprises at least one member selected from the group consisting of isopropyl alcohol, ethanol, n-propanol, t-butanol, 2-butanol, pentanol, hexanol and povidone- .
A porous bead, a natural fragrance, or a natural additive.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140190832A KR20160079459A (en) | 2014-12-26 | 2014-12-26 | Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component |
| PCT/KR2015/012800 WO2016104966A1 (en) | 2014-12-26 | 2015-11-26 | Cleansing or disinfecting composition having antiviral activity by comprising green tea extract as active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140190832A KR20160079459A (en) | 2014-12-26 | 2014-12-26 | Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160079459A true KR20160079459A (en) | 2016-07-06 |
Family
ID=56150940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140190832A KR20160079459A (en) | 2014-12-26 | 2014-12-26 | Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR20160079459A (en) |
| WO (1) | WO2016104966A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018212428A1 (en) * | 2017-05-17 | 2018-11-22 | (주)하이씨엔티 | Hydrogen soap and manufacturing method therefor |
| KR102278545B1 (en) | 2021-03-15 | 2021-07-16 | 홍성창 | Antiviral Composition and manufacturing method thereof |
| KR20240037390A (en) | 2022-09-13 | 2024-03-22 | 주식회사 진생바이팜 | Antiviral composition containing ginseng extract and steroid compound as active ingredients |
| US11938163B2 (en) | 2020-06-09 | 2024-03-26 | Amorepacific Corporation | Composition for improving respiratory health continuously exposed to particulate matter atmosphere |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050001737A (en) | 2003-06-26 | 2005-01-07 | 종근당건강 주식회사 | A anti-inflammatory/abirritant composition for cleaning a anus, extracted from mixture of mugwort, purslane and green tea plant |
| KR20050054532A (en) | 2003-12-05 | 2005-06-10 | 염재한 | A washing water of green tea |
| KR101060794B1 (en) | 2005-02-23 | 2011-08-30 | 주식회사 엘지생활건강 | Antiviral agent against influenza virus consisting of plant extracts and hygiene products containing same |
| KR101196113B1 (en) | 2010-12-07 | 2012-10-30 | 전라남도 | Method for manufacturing HandWash and HandWash composition Thereof containing natural oriental plant extracts |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030070487A (en) * | 2002-02-25 | 2003-08-30 | 김대승 | The preparation of antimicrobial cleansing deodorant |
| KR20060084516A (en) * | 2005-01-20 | 2006-07-25 | 황인숙 | The stabilization of several natural herb powders by using natural materials and the cosmetics using these results |
| KR101128450B1 (en) * | 2008-12-11 | 2012-03-28 | (주)바이오제닉스 | Composition comprising ß-cyclodextrin derivatives as a stabilizing agent |
| KR20110049480A (en) * | 2009-11-05 | 2011-05-12 | 오화영 | Disinfectant composition and tissue impregnated with the same |
| KR101626048B1 (en) * | 2009-11-26 | 2016-06-01 | (주)아모레퍼시픽 | Antibacterial detergent composition |
-
2014
- 2014-12-26 KR KR1020140190832A patent/KR20160079459A/en not_active Application Discontinuation
-
2015
- 2015-11-26 WO PCT/KR2015/012800 patent/WO2016104966A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050001737A (en) | 2003-06-26 | 2005-01-07 | 종근당건강 주식회사 | A anti-inflammatory/abirritant composition for cleaning a anus, extracted from mixture of mugwort, purslane and green tea plant |
| KR20050054532A (en) | 2003-12-05 | 2005-06-10 | 염재한 | A washing water of green tea |
| KR101060794B1 (en) | 2005-02-23 | 2011-08-30 | 주식회사 엘지생활건강 | Antiviral agent against influenza virus consisting of plant extracts and hygiene products containing same |
| KR101196113B1 (en) | 2010-12-07 | 2012-10-30 | 전라남도 | Method for manufacturing HandWash and HandWash composition Thereof containing natural oriental plant extracts |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018212428A1 (en) * | 2017-05-17 | 2018-11-22 | (주)하이씨엔티 | Hydrogen soap and manufacturing method therefor |
| US11938163B2 (en) | 2020-06-09 | 2024-03-26 | Amorepacific Corporation | Composition for improving respiratory health continuously exposed to particulate matter atmosphere |
| KR102278545B1 (en) | 2021-03-15 | 2021-07-16 | 홍성창 | Antiviral Composition and manufacturing method thereof |
| KR20240037390A (en) | 2022-09-13 | 2024-03-22 | 주식회사 진생바이팜 | Antiviral composition containing ginseng extract and steroid compound as active ingredients |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016104966A1 (en) | 2016-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20160079473A (en) | Preparation method of cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component | |
| JP5092145B2 (en) | Anti-norovirus agent and composition containing the same | |
| US7578970B2 (en) | Methods of inhibiting growth of microorganisms using disinfectant compositions comprising orange oil mixtures | |
| JP5670201B2 (en) | Antiviral agent and antiviral composition against envelope virus belonging to influenza A virus genus | |
| CN103347386B (en) | Antimicrobial compositions | |
| WO2011044916A1 (en) | Multipurpose eco-friendly disinfecting composition comprising nano size antibacterial agent | |
| KR20160079459A (en) | Cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component | |
| CN104434669A (en) | Traditional Chinese medicine disinfectant and preparation method thereof | |
| CN103945693B (en) | Antimicrobial micro emulsion composition | |
| CN111631996A (en) | Skin-nourishing hand-washing-free disinfection gel solution and preparation method thereof | |
| CN104523466A (en) | Chinese herbal medicinal skin mucosa disinfection wet wipe | |
| CN104622741A (en) | Skin caring and moisturizing hand cleaner | |
| CN104513716A (en) | Botanical environmentally-friendly kitchen cleaner | |
| CN103110541A (en) | All-natural washing-free disinfectant hand sanitizer | |
| KR102252009B1 (en) | Antiviral or antibacterial composition containing extracts of Torreya nucifera leaf | |
| CN110946159A (en) | Plant essence biological compound clothing mildew sweat odor removing agent | |
| KR101121615B1 (en) | Antibacterial Detergent Composition | |
| CN113876680A (en) | Plant wet tissue and preparation process thereof | |
| CN105456180A (en) | Bactericidal rash preventing solution for infant wet tissues and preparation method thereof | |
| KR102344582B1 (en) | Composition for antiviral comprising natural extracts | |
| CN106538625A (en) | A kind of biosynthesis Nano Silver fishery disinfectant | |
| CN112587421A (en) | Washing-free hand disinfection gel containing plant extracts and preparation method and application thereof | |
| KR102397365B1 (en) | Antiviral composition comprising chlorine dioxide solution and natural product-derived substance | |
| KR102235917B1 (en) | Antibacterial composition containing natural material | |
| CN103785053A (en) | Novel air disinfecting and refreshing agent containing active matters from marine organisms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| A302 | Request for accelerated examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |