CN102845637A - Chicken feed capable of preventing and treating avian influenza and Chinese herbal additive used therein - Google Patents

Chicken feed capable of preventing and treating avian influenza and Chinese herbal additive used therein Download PDF

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CN102845637A
CN102845637A CN2012103168931A CN201210316893A CN102845637A CN 102845637 A CN102845637 A CN 102845637A CN 2012103168931 A CN2012103168931 A CN 2012103168931A CN 201210316893 A CN201210316893 A CN 201210316893A CN 102845637 A CN102845637 A CN 102845637A
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CN102845637B (en
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张绪伟
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JIANGSU KAIQI ANIMAL HUSBANDRY Co Ltd
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杨高林
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Abstract

The invention provides a chicken feed capable of preventing and treating avian influenza. The chicken feed comprises, by weight, 0.01 to 0.1 part of tryptophan, 5 to 10 parts of feed-grade zeolite powder, 1 to 2 parts of Maxus, 30 to 50 parts of wheat bran, 10 to 20 parts of smashed corn, 10 to 20 parts of fish meal, 5 to 10 parts of rice chaff and 1 to 2 parts of a Chinese herbal additive. Bulk drugs for the Chinese herbal additive comprise weeping forsythia capsule, milkvetch root, tangshen, amur cork-tree bark, baical skullcap root, virgate wormwood herb, Chinese magnoliavine fruit, atractylodes rhizome, isatis root, bighead atractylodes rhizome, dyers woad leaf, ineleaf schizonepeta herb, red sage root and white peony root. The chicken feed provided by the invention can reduce outbreak of avian influenza, is safe and convenient to use, enables high marketable fattened stock of chicks to be obtained, creates good social values and economic benefits, can positively influence growth performance of chicks, substantially increases the survival rate of chicks, accelerates growth of laying hens and eradicates harm of chemical medicines to chicks and side-effects indirectly influencing food safety.

Description

A kind of chicken feed and Chinese medicine additive thereof of preventing and treating bird flu
Technical field
The present invention relates to a kind of use animal, plant, feed and Chinese medicine additive thereof that ore is produced as raw material, particularly a kind of chicken feed and Chinese medicine additive thereof of preventing and treating bird flu.
Background technology
Bird flu, full name bird class influenza is the zoonosis that is caused by virus, usually only infects birds, rare situation can infected pigs.The avian influenza virus height infects the people for specific species but can cross over the species obstacle in rare situation.Since 1997 after Hong Kong finds that the mankind also can infect bird flu, this illness causes showing great attention to of whole world health organization.Thereafter, this disease sporadicly breaks out in the Asia always, but in December, 2003, bird flu is multinational in East Asia, mainly seriously breaks out in Vietnam, Korea S, Thailand, and causes the several patients of Vietnam to die.China also is the severely afflicated area, and numerous raisers were suffered heavy losses.
The bird flu of recording in the document betides 1878 Italy the earliest.At that time, chicken group mortality occured in Italy, was called as at that time checken pest.To nineteen fifty-five, scientist confirms that its Causative virus is influenza A virus.After this, this disease is renamed as bird flu.Bird flu was found over more than 100 year, and the mankind do not grasp specific prevention and methods for the treatment of, only can prevent that it from spreading with the method for sterilizing, isolate, slaughtering in a large number the fowl poultry.
The main route of transmission symptom of bird flu is different according to kind, age, sex, accompanying infection degree, virus virulence and the environmental factor etc. of infected poultry, and main manifestations is respiratory tract, alimentary canal, reproductive system or neural unusual.Common sympton has: sick chicken spirit is depressed, and feed consumption reduces, and becomes thin; The broodiness of hen strengthens, and egg production descends; Slight until serious respiratory symptom comprises cough, sneezes and sheds tears in a large number; Head and face's oedema, neurological disorders and diarrhoea.Any all possibilities in these symptoms occur separately or with different combinations.Sometimes outbreak of disease is very rapid, has just found chicken death when not having manifest symptom.
Bird flu did not wait from several hours to several days incubation period, and its length is relevant with the kind pathogenic, that infect viral dosage, route of infection and infected fowl of virus.
Because bird flu is the poultry that caused by A type influenza virus and a kind of syndrome from respiratory disease to multiple symptoms such as seriousness septicemia of wild fowl, there is generation many countries and regions in the world at present, have caused huge economic loss to aviculture.This avian influenza virus, mainly cause general or the respiratory system disease of bird, the poultry such as chicken, turkey, duck and quail and wild bird, aquatic bird, seabird etc. all can infect, incidence waits extremely various from acute septic death to asymptomatic band poison, depend primarily on the resistance of carrier and infect types of viruses and virulence.
How reducing the outburst of bird flu, reduce the loss, can economize on resources again, reduce production costs, then is the problem that the present invention faces.Then add the growth promoter of safety nuisance free, such as Chinese herbal feed preparation, enzyme preparation, probiotics etc., competence exertion laying hen optimum growh potential improves laying rate, reaches good growth result, obtains good economic benefits.In feed, add the growth promotion performance, particularly improve laying rate, the feed formulations that improves feed conversion rate is the key technology of aquaculture research, Chinese herbal medicine is that the feed formulations of the soil body is followed Traditional Chinese Medicine theory and modern animal nutrition principle, have with food homology, consubstantiality, with the characteristics of usefulness, have the double action of nutrition and medicine concurrently, its immunity substance mass-energy enhanced machine body immunity function, improve that animal is anti-stress, anti-disease ability, improve breeding performonce fo animals, go back simultaneously toxic side effect little, have no drug resistance, be difficult for the advantages such as residual.Facts have proved, the Chinese herbal feed formulation application is energy Effective Raise laying rate in laying hen produces, and improves Egg Quality, and its ecological benefits, economic benefit and social benefit are worth further investigation.
China's Chinese herbal medicine resource vast in territory divides abundant, aspect the development Chinese herbal and crude drugs preparations huge potentiality are being arranged, a large amount of production practices and scientific research have confirmed that also Chinese herbal medicine has many nutritional labelings and bioactivator, such as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, have non-specific antibacterial action.Therefore abandon the chemical classes preparation, use the relieved feed formulations of safety, improve the speed of growth of laying hen and laying rate and be our problem in the urgent need to address.
Summary of the invention
Technical problem to be solved by this invention is, a kind of chicken feed and Chinese medicine additive thereof of the control bird flu simple, that manufacture craft is easy of filling a prescription is provided, and can reach the reduction bird flu and break out, and safety, easy to use, the rate of animals delivered to the slaughter-house is high, can create preferably social value and economic interests.The present invention can bring into play the drug effect of Chinese herbal medicine to greatest extent, can economize on resources again, reduces production costs.Have the double action of the property of medicine and trophism concurrently, both preventable disease can improve production performance again; Not only can bactericidal, and can regulate organic immunity function, abandon chemicals to the injury of chicken, the side effect of remote-effects food security, adopt brand-new Chinese medicine fodder preparation, it can effectively improve breeding performonce fo animals, simultaneously toxic and side effect little, have no drug resistance, be difficult for the advantages such as residual; Energy Effective Raise laying rate is improved Egg Quality.
For solving the problems of the technologies described above, the invention provides a kind of chicken feed of preventing and treating bird flu, comprising: tryptophan, feed grade zeolite powder, the U.S. element of effect, wheat bran, broken corn, fish meal, rice chaff and Chinese medicine additive; The bulk drug of described Chinese medicine additive further comprises: the capsule of weeping forsythia, the Radix Astragali, Radix Codonopsis, golden cypress, the root of large-flowered skullcap, oriental wormwood, the fruit of Chinese magnoliavine, rhizoma atractylodis, Radix Isatidis, the bighead atractylodes rhizome, folium isatidis, schizonepeta, the red sage root, the root of herbaceous peony.
The ratio of weight and number of the various raw materials of described chicken feed can for: tryptophan 0.01-0.1 part, feed grade zeolite powder 5-10 part imitates U.S. plain 1-2 part, wheat bran 30-50 part, broken corn 10-20 part, fish meal 10-20 part, rice chaff 5-10 part, Chinese medicine additive 1-2 part.
The ratio of weight and number of each bulk drug can be the capsule of weeping forsythia 10～20 weight portions in the described Chinese medicine additive, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions, the root of herbaceous peony 10～20 weight portions.
The ratio of weight and number of each bulk drug can also be the capsule of weeping forsythia 10～15 weight portions in the described Chinese medicine additive, the Radix Astragali 10～15 weight portions, Radix Codonopsis 10～15 weight portions, golden cypress 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions and the root of herbaceous peony 10～20 weight portions.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine additive of the chicken feed of preventing and treating bird flu, and the formulation of described Chinese medicine additive is pulvis, and step is:
A. bulk drug is pulverized, crossed the 100-120 mesh sieve, collect the fine powder by sieve;
B. can not soak by the meal of sieve 1-2 hour input multi-function extractor extraction twice in the water, and add 5-10 times of water gaging for the first time and decocted 1-2 hour, add 4-8 times of water gaging decoction 1-2 hour for the second time, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, grinds to form fine powder;
C. the fine powder that obtains in above-mentioned two steps is mixed.
For solving the problems of the technologies described above, the present invention provides again a kind of preparation method of Chinese medicine additive of the chicken feed of preventing and treating bird flu, the formulation of described Chinese medicine additive is powder, step is: described bulk drug is mixed by proportioning, drop into pulverizer and pulverize, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with alcohol, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and then remove supernatant, the liquid that stays is put into oven for drying, makes fine powder.
For solving the problems of the technologies described above, the present invention provides a kind of Chinese medicine additive of preventing and treating the chicken feed of bird flu again, and the ratio of weight and number of its each bulk drug is: the capsule of weeping forsythia 10～20 weight portions, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions, the root of herbaceous peony 10～20 weight portions.
Described Chinese medicine additive, the ratio of weight and number of each bulk drug can also be the capsule of weeping forsythia 10～15 weight portions, the Radix Astragali 10～15 weight portions, Radix Codonopsis 10～15 weight portions, golden cypress 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions and the root of herbaceous peony 10～20 weight portions.
Described Chinese medicine additive, the ratio of weight and number of each bulk drug also can be the capsule of weeping forsythia 10～15 weight portions, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～15 weight portions, the root of herbaceous peony 10～15 weight portions.
Described Chinese medicine additive, the ratio of weight and number of each bulk drug can be the capsule of weeping forsythia 15～20 weight portions, the Radix Astragali 15～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 15～20 weight portions, the root of large-flowered skullcap 15～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 15～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 15～20 weight portions, schizonepeta 15～20 weight portions, the red sage root 15～20 weight portions, the root of herbaceous peony 15～20 weight portions again.
Described chicken feed Chinese medicine additive, its formulation can be pulvis, granule and powder.
The useful technique effect of the present invention is: the survival rate that greatly improves chicken by nontoxic Chinese herbal medicine; Reduce the risk of bird flu, accelerate the growth of laying hen; Abandon chemicals to the injury of chicken, brand-new Chinese herbal feed additive is adopted in the side effect of remote-effects food security, and it can effectively improve breeding performonce fo animals, simultaneously toxic and side effect little, have no drug resistance, be difficult for the advantages such as residual; Energy Effective Raise laying rate is improved Egg Quality, reaches the requirement of pollution-free food pure natural, can obtain good economic benefit.
The specific embodiment
China's Chinese herbal medicine resource vast in territory divides abundant, aspect the development Chinese herbal and crude drugs preparations huge potentiality are being arranged, a large amount of production practices and scientific research have confirmed that also Chinese herbal medicine has many nutritional labelings and bioactivator, such as alkaloid, polysaccharide, volatile oil, boots matter, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, have non-specific antibacterial action.Therefore abandon the chemical classes preparation, use the relieved feed formulations of safety, making food reach the delicious effect of safety is our consistent pursuit; The more important thing is, the advantage of Chinese herbal and crude drugs preparations uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity have been kept, the long-term use and drug residue free, without the resistance to the action of a drug with have no side effect, be good Green medicament preparation, also catered to consumers in general and poultry farming person to the pursuit of the poultry prod of green non-pollution no drug residue, in poultry production, seem more meaningful so make feed addictive with Chinese herbal medicine; But, for its application on domestic fowl farming, mostly rest on the feeding experiment, the lab analysis report is less, its hygiogenesis is inferred theoretically more, present research both domestic and external mainly concentrates on the research of its production performance that improves poultry and feed conversion rate, raising immunity of organisms aspect.
The U.S. element of effect (Maxus) is the novel enteron aisle metabolism regulators of being developed by Lilly Co., Eli., and active ingredient is avilamycin (Avilamycin), domestic also once be translated into " avilamycin ".Its structure is special, belong to Orthromycin, at present, in people's veterinary drug only avilamycin belong to such antibiotic. the U.S. element of effect does not absorb via enteron aisle, do not disturb simultaneously the growth of normal intestinal flora, but the growth performance of Effective Raise livestock and poultry and resistance against diseases thereof, improve livestock and poultry daily gain and price of deed rate, prevention is because the broiler chicken necrotic enteritis that the gas capsular clostridium causes, improve the bedding and padding quality, use experience for many years proves, Various Seasonal, kind, daily ration form, under the raising condition, and the result of use of the U.S. element of effect is very remarkable and consistent.At present in European Union, Japan, Brazil, the main aquaculture in the worlds such as Thailand country imitates U.S. element and all is widely used in the animal and fowl fodder, and effect is remarkable.
Chinese herbal feed additive, refer to take and take the subjects theory such as raising and feed industry and technology as support single and compound Chinese herbal and crude drugs preparations or the intermixture developed as the leading factor with the traditional theory that China concerns the physical property of large right Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing flavor (sour, sweet, bitter, peppery, salty) and material.China research Chinese herbal medicine has long history, and before more than 2,000 year, " the fertile globefish method of numb salt " in " Huainan ten thousand is finished arts " that the epoch Liu An of the Western Han Dynastry writes is to make an addition to the earliest literature record in the feed about Chinese herbal medicine.Eastern Han Dynasty's epoch Chinese herbal medicine monograph Shennong's Herbal is loaded with: " the Chinese catalpa leaf is raised loose two times of pig " " paulownia is raised two times of the fertile people of pig " etc.The Jia Si Important Arts for the People's Welfare that warship is write in Northern and Southern Dynasties' epoch carry: " get three liters at wheat evil end, and paddy is raised horse ', control Malaysia and China's paddy card.Ming Dynasty's Li Shizhen (1518-1593 A.D.) is loaded with a large amount of relevant knowledges in " herbal guiding principle day ", such as " pipewort, can groom order fertile ", " yncaria stem with hooks enters several cun in wheat, cooks, and grooms easily fertile ", " root tuber of aromatic turmeric, horse is used it, invigorates blood circulation and mends " etc.Since late 1970s, China expert, scholar begin to notice Chinese herbal medicine as the bright prospects of feed formulations, this have been carried out comparatively deep research and application, and have occurred a collection of specially to research and develop Chinese herbal medicine and preparation as the veterinary drug producer of soil.A large number of experiments show that the Chinese herbal feed preparation can promote animal growth, improve production performance, improve the livestock products quality.Fear sound (1993) etc. adds fennel seeds in layer diets, found that yolk color, chicken flavor all have clear improvement.More strengthen us and developed the resolution of Chinese medicine preparation.Medium-height grass the effective elements of the medicine soil will have alkaloid, becomes class, volatile oil, naked class, resinae, organic acid, carbohydrate, egg is from matter, many skins and amino acid, and grease, wax, phytochrome etc.Participate in the microcirculation in the animal body after active principle is absorbed by the animal body, improve chemical environment and the physical environment of cell, the potential of excitating organism self, thereby the normalization of realization histocyte organ dysfunction.Alkaloids (pickles alkali etc.), two classes (ginseng soap two etc.) are strengthened the reticuloendothelial system phagocytic function, and can generate by enhancing antibody, promote antigen-antibody reaction and lymphocyte transformation; Polysaccharide (yellow polysaccharide, yellow luxuriant polysaccharide, Codonopsis pilosula polysaccharide, the silver-colored imperial polysaccharide etc. of waiting) is immunocompetent main matter, has the reaction of the thymus gland of promotion, stimulating expression of macrophage gulp down the sunlight function; Organic acid (forulic acid of aristolochic acid, cinnamic acid and sodium salt thereof, Radix Codonopsis, the water-soluble acid composition of Radix Codonopsis etc.) is regulated the pH value in the stomach and intestine, prevent the breeding of harmful bacteria and the activity of raising enzyme, promote eubolism in the animal body, thereby improve the utilization rate of nutriment, promote the performance of breeding performonce fo animals; Volatile oil (allicin etc.) can obviously improve lymphocyte transformation rate, T lymphocyte acidity and a one acetic acid Cai fat positive rate, makes central lymphoid organs and peripheral lymphoid organs propagation, strengthens cellular immune function.Chinese medicine preparation of the present invention can improve reproductive endocrine system by the integral body adjustment of its body self, promotes follicular development, regulates uterine contractile, is beneficial to and lays eggs, and guarantees and raising body production function.Energy Effective Raise laying rate is improved Egg Quality, reaches the requirement of pollution-free food pure natural,
Specific embodiment 1: get tryptophan 2g, feed grade zeolite powder 1000g is imitated U.S. plain 100g, wheat bran 3000g, and broken corn 1000g, fish meal 1000g, rice chaff 500g, Chinese medicine additive 100g of the present invention is mixed into feed.
Specific embodiment 2: get tryptophan 5g, feed grade zeolite powder 800g is imitated U.S. plain 120g, wheat bran 3500g, and broken corn 1300g, fish meal 1100g, rice chaff 600g, Chinese medicine additive 120g of the present invention is mixed into feed.
Specific embodiment 3: get tryptophan 6g, feed grade zeolite powder 400g is imitated U.S. plain 110g, wheat bran 3000g, and broken corn 1000g, fish meal 1000g, rice chaff 600g, Chinese medicine additive 150g of the present invention is mixed into feed.
Specific embodiment 4: get capsule of weeping forsythia 150g, Radix Astragali 150g, Radix Codonopsis 150g, golden cypress 150g, root of large-flowered skullcap 150g, oriental wormwood 150g, fruit of Chinese magnoliavine 150g, rhizoma atractylodis 150g, Radix Isatidis 150g, bighead atractylodes rhizome 150g, folium isatidis 150g, schizonepeta 150g, red sage root 150g and root of herbaceous peony 150g.Grind to form and can cross 100～200 order fine powders, preparation cost invention Chinese medicine additive, the grinding particle size of bulk drug is 3～5m m, makes its fine powder amount reach 90% of total material.
Specific embodiment 5: described bulk drug capsule of weeping forsythia 120g, Radix Astragali 130g, Radix Codonopsis 140g, golden cypress 100g, root of large-flowered skullcap 100g, oriental wormwood 120g, fruit of Chinese magnoliavine 140g, rhizoma atractylodis 130g, Radix Isatidis 100g, bighead atractylodes rhizome 100g, folium isatidis 130g, schizonepeta 120g, red sage root 100g and root of herbaceous peony 100g are mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with alcohol, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and then remove supernatant, the liquid that stays is put into oven for drying, and the temperature of oven drying is 105 ℃, drying time 15-25min.
Specific embodiment 6: bulk drug capsule of weeping forsythia 150g, Radix Astragali 150g, Radix Codonopsis 150g, golden cypress 150g, root of large-flowered skullcap 200g, oriental wormwood 200g, fruit of Chinese magnoliavine 150g, rhizoma atractylodis 150g, Radix Isatidis 150g, bighead atractylodes rhizome 150g, folium isatidis 150g, schizonepeta 150g, red sage root 150g and root of herbaceous peony 200g are pulverized grind to form 100～200 order fine powders first, the grinding particle size of bulk drug is 3～5mm, makes its fine powder amount reach 90% of total material.Again with in the described feed component, feed grade zeolite powder 1000g, wheat bran 3000g, broken corn 1000g, fish meal 1000g, rice chaff 500g is mixed and made into basal feed by proportioning; Then in basal feed, add tryptophan 5g, imitate the good Chinese medicine additive 150g of U.S. plain 150g proportioning and become material.
Various property of Chinese materia medica introductions in the Chinese medicine additive:
The capsule of weeping forsythia is bitter, is slightly cold.Return lung, the heart, small intestinl channel.Function is clearing heat and detoxicating, dispersing swelling and dissipating binds.Be used for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched renal shutdown.The medicinal part of the capsule of weeping forsythia mainly is fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, saponin, citrin etc.Have the effects such as heat-clearing, detoxifcation, dissipating bind apocenosis.Cure mainly warm, sore, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter, cold nature.Clearing heat and detoxicating, mass dissipating and swelling eliminating.The anaesthetic bitter, cool in nature.Clearly " association's day ", antidiarrheal.Cure mainly: Chinese medicine is controlled pyreticosis from the beginning of, anemopyretic cold, and heating is vexed, abscess of throat, and macula, erysipelas, scrofula, the carbuncle pyogenic infections from tumour or sore, acute nephritis, heat is drenched.The anaesthetic subcutaneous ulcer of harnessing the Yellow River, intestines shouting pain, " association day " disease, intestines heat.Sheng Nong's herbal classic ": main fever and chills, the mouse impotence, scrofula, carbuncle is swollen, dislikes sore, goiter and tumor, knot heat, disease due to noxious agents produced by various parasites.
Ching-chieh is hot, tepor.Return lung, Liver Channel.The loose wind that induces sweat, promoting eruption.Be used for flu, headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.Horse schizonepeta one medicine is given birth to the effect that expels pathogenic wind from the body surface is arranged, and fries charcoal and then is used for hemostasis.Join windproof, notopterygium root, control chill table disease; Join honeysuckle flower, the capsule of weeping forsythia, peppermint, control wind-heat table disease; Join gypsum, control headache due to pathogenic wind-heat; Join great burdock achene, balloonflower root, living Radix Glycyrrhizae, control abscess of throat; Join charred Flos Sophorae, treating hematochezia; Join cogongrass rhizome, control nosebleed epistaxis.Schizonepeta and purple perilla all can inducing sweat and dispelling exogenous evilses, but the loose cold power of purple perilla is strong, partially enters gas and divides, again can regulating the flow of QI to ease the stomach; And the schizonepeta power of dispeling the wind wins, and partially enters blood system, fries charcoal and can stop blooding again.Therefore purple perilla commonly used in the side of regulating the flow of vital energy, and in the middle of blood-regulating prescription multiplex schizonepeta.
The Radix Astragali is take qi-restoratives as main, can invigorating qi for strengthening superficies, and diuresis holder poison, apocenosis, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, sore cave in, purulence becomes not burst or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of for a long time disunion.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for the generation of some infectious disease of prevention." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly then sends out, and has sweat then to end." be the good medicine of promoting resistance and defence disease.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibiotic not worse than the coptis, and does not develop immunity to drugs.We are used in the fungal culture miscellaneous bacteria and infect special severity by the strong characteristics of broad-spectrum antibacterial action, and are fine with root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia wins heat, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory is also analysed it, then all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from pursuing, the source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber makes us obstructed through closing, damp and hot solution, then Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is then stayed knot, and is that the swollen stain of carbuncle is mashed also: fiery ulcer person, the internal heat blood trouble also, cool blood heat extraction, then self-healing also.
The root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, band is lower, and it is obstructed that married woman's blood closes, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, beneficial gas, day hot disease of row, the pest miasma, frightened mad, married woman's blood fortune, and intestines wind are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the sore scabies, headache makes eye bright, and hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.
Folium isatidis is mainly used in the heat poison and sends out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.In recent years clinically extensive use of this medicine is controlled above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, but both single was applied to prevention, can cooperate radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc. again, can removing summer-heat the gas heat that divide, seek minute malicious, availablely control various encephalitis, and comparatively suitable with the partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." " book on Chinese herbal medicine is just ": " controlled the hot poison of pestilence and goes mad, the wind-heat macula, and large carbuncle swells and ache, and relieving thirst and restlessness ends nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.
Radix Isatidis clinically clearing heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent drug.Result of study shows, Radix Isatidis has the pyrogen effect that can cause hyperthermia in the significant removing body." classification herbal medicine " carries: " separate all poison and dislike sore, loose poison reduces internal heat." and cheap, toxic and side effect is little, is very popular clearing heat and detoxicating good medicine.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.Be used for irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.Be used for the sternal rib hypochondriac pain, arthralgia due to wind-dampness, the abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, bitterly have good effect through amenorrhoea.. " detailed outline " carries: the red sage root, by " the sensible opinion of married woman " cloud, Siwu Tang is controlled the gynecopathy, pays no attention to antenatal postpartum, through water what, all can be general, the only flavor red sage root is loose, cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and the stillborn foetus that falls, under only metrorrhagia stagnates, the menstruation regulating arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.
Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Be used for insufficiency of the spleen food few, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carries it: monarch, distinguish the flavor of sweet, and suffering, nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, sputum is removed in appetizing, except fever and chills, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in the abdomen is vomited and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
Radix Codonopsis is China's traditional tonic commonly used, and the Radix Codonopsis that produce take area, Shangdang, Shanxi ancient times has tonifying middle-Jiao and Qi as top grade, the effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis contain various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, have to strengthen immunity, hemangiectasis, step-down, improve microcirculation, strengthen the effect such as hematopoiesis function.The leucocyte that in addition chemotherapy radiotherapy is caused descends castering action is arranged.
The golden cypress heat-clearing and damp-drying drug, purging intense heat and detonicating is except the hectic fever due to yin clearind deficient heat.Be used for damp-heat dysentery, jaundice, band is lower, and heat is drenched, beriberi, impotence is warded off, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution is nourishing Yin and falling fire.For fire excess from yin deficiency, the night sweat hectic fever due to yin.The golden cypress antibiotic effective ingredient is jamaicin, thus its pharmacological action and coptis broadly similar, but content is low than the coptis.In vitro test to staphylococcus aureus, pneumococcus, corynebacterium diphtheriae, Streptococcus viridans, shigella dysenteriae (except Song Nei Shi), hemolytic streptococcus, meningococcus, comma bacillus, bacillus anthracis all effectively or stronger inhibitory action arranged; Hay bacillus, Bordetella pertussis, clostridium tetani also there is inhibitory action; Without direct repression, but the bacterium number is reduced to H37Rv, mycobacterium tuberculosis, but concentration present bacteriostasis when reaching 1%.When inoculating Mycobacterium hominis (H37Rv) do experiment treatment with cavy, curative effect oral or injection is all very poor.To the cavy of inoculation Mycobacterium bovis, during the hydrochloric acid crystal intramuscular injection of phellodendron extract, certain curative effect is arranged.Golden cypress is taken a favorable turn to clinical symptoms and the x-ray inspection of tuberculosis patient, and is better than the coptis.In test tube, golden cypress decoction or preserved material have in various degree bacteriostasis to common pathogenic fungus.Its water decoction can not kill Leptospira (dosage needs than the large I of the coptis doubly).External Trichomonas vaginalis also there is weak effect.It is reported, golden cypress acid-base method extract is made 1:1 golden cypress liquid, can treat bacillary dysentery with enema, can fully recover in general 2-4 days.The golden cypress treatment solution is treated chronic prostatitis with iontophoresis, and total effective rate reaches 97.3%.
The fruit of Chinese magnoliavine contains abundant organic acid, vitamin, flavonoids, phytosterol and the lignan of potent reactivation (for example schizandrin, deoxyschizandrin or fruit of Chinese magnoliavine fat element) is arranged, it also is one of minority medicinal material that has concurrently essence, gas, refreshing three large helps, the strong liver of the beneficial gas of energy, the efficient of promoting the cells exclude refuse, supply more oxygen, construction and uses energy, raising memory and property endurance.The fruit of Chinese magnoliavine has antiinflammation, to prevent hepar damnification, activates anabolic process promoting impaired hepatocellular reparation, and can strengthen the activity of DNA (DNA) synthetic and ornithine decarboxylase, the regeneration liver cell.Carbon tetrachloride (CCl4) is a kind of material that the tool of liver is poisoned wherein.Countless studies show that, the potent liver-protecting efficacy of the fruit of Chinese magnoliavine can resist the toxic action of CCl4.This shows, the fruit of Chinese magnoliavine avoids aspect the daily toxin infringement very large effect being arranged at the protection liver.
The oriental wormwood clearing heat and promoting diuresis; Removing jaundice.Cure mainly: jaundice, difficult urination, wet sore itch, infectious jaundice type hepatitis.Deng. pharmaceutical research has cholagogic, and liver function protecting is analgesic, anti-inflammatory, and reducing blood lipid, step-down expands hat to wait effect, and certainly, this is the research that western medicine extraction oriental wormwood composition is worked it out, how bad judgement of effect in the clinical practice.Chen Su toxicity is that maincenter suppresses, show as drowsy, salivation etc.The oriental wormwood consumption is excessive to cause dizziness, feel sick, and diarrhoea, epigastric discomfort, acute Bile duct injury, but ARR report is also arranged. the oriental wormwood of therapeutic dose generally can not caused serious damage.Oriental wormwood has significant hepatoprotective effect, to first, and hepatitis B, icteric hepatitis has significant curative effect.Cholagogic is arranged, promote choleresis, the effect that cholic acid and bilirubin are discharged in the increase bile. can increase the heart CF, improve microcirculation, and have hypotensive, reducing blood lipid, anticoagulation, diuresis is analgesic relievings asthma, and drives away roundworm and suppresses the effect of multiple pathogenic dermatophyte and bacterium.
Rhizoma atractylodis are drying damp and strengthening spleen, and expelling wind and clearing away cold makes eye bright.Be used for abdominal fullness and distention, the oedema of having loose bowels, beriberi Wei lame, arthralgia due to wind-dampness, anemofrigid cold, yctalopia.Main the spleen and stomach being stranded by dampness; Burnout is had a liking for sleeping; Born of the same parents' ruffian abdominal distension; Poor appetite; Tell and have loose bowels; Phlegm and retained fluid; Wet swollen; The illness that has not attacked the vital organs of the human body folder is wet; The heavy pain of body; The bi Zheng warm nature; Podomere is ached and is being weighed; The impotence folds in a garment.Be used for wet resistance taste, abdominal fullness and distention, the cold-dampness leukorrhea, damp-warm diseases and damp invasion of lower energizer, pin swelling and pain in knee, impotence are soft unable.Controlling wet resistance taste, and seeing the thick disease such as turbid of abdominal fullness and distention, poor appetite, lassitude hypodynamia, white and greasy fur, normal and the compatibility application such as the bark of official magnolia, dried orange peel; Control the cold-dampness leukorrhea, can join the root of Dahurain angelica with using.Such as damp and hot leukorrhea, can join the wind-weed, kuh-seng, Patrinia heterophylla again; Damp invasion of lower energizer, pin swelling and pain in knee, impotence are soft unable, can join golden cypress, the root of bidentate achyranthes, coix seed and be equal to usefulness; The damp-warm syndrome disease can be joined gypsum, the wind-weed is equal to usefulness.
One. the pharmacodynamic experiment explanation
The present invention is to provide a kind of chicken feed Chinese medicine preparation, for proving its result for the treatment of and security, the inventor uses the pulvis for preparing by the method that provides in above-described embodiment to carry out toxicology, pharmacodynamics and clinical testing, and result of study is as follows:
1, causes that with citric acid chemistry stimulus method the guinea pig cough smears the antitussive action of Chinese medicine additive pulvis of the present invention to observe the cavy external application, after Chinese medicine additive 1.25g of the present invention and 2.5g crude drug/g smear 1 hour as a result, the guinea pig cough obviously prolongs incubation period, compare with the blank group, the P value is respectively less than 0.05 and 0.01; Guinea pig cough's number of times obviously reduces, and compares with the blank group, and the P value shows to have obvious antitussive action all less than 0.01.Be coated with outward and oral effect suitable (P＞0.05).
2, use the Salmonella typhoid Vi vaccine and make refrigeration function after rabbit body temperature raises to observe rabbit Chinese medicine additive pulvis of the present invention, the result smears Chinese medicine additive pulvis 2.5g crude drug/g of the present invention, after administration, can obviously suppress the rabbit body temperature rising in 1.0 and 1.5 hours, compare with model control group, the P value is all less than 0.05.
3, using staphylococcus aureus and Friedlanders bacillus injects to mouse peritoneal, observe the bacteriostatic activity of Chinese medicine additive pulvis of the present invention, the result shows, Chinese medicine additive pulvis 1.25g of the present invention and 2.5g crude drug/g all have in various degree inhibitory action to above-mentioned two kinds of bacteriums.
4, use Respiratory Syncytial Virus(RSV) (RSV), observe the antivirus action of Chinese medicine additive pulvis of the present invention, result of the test shows, in the situation that the Hep-2 passage cell infects 10TCID 50 Respiratory Syncytial Virus(RSV), Chinese medicine additive of the present invention cytopathogenic effect to Respiratory Syncytial Virus Strain Long under 3.9mg crude drug/ml concentration has inhibitory action.
5, be coated with Chinese medicine additive pulvis 1.25g of the present invention, 2.5g crude drug/g outward, all can obviously increase the phenol red discharge rate of mouse tracheae (P＜0.05), show that it has obvious phlegm-dispelling functions.Its outer being coated with and oral effect suitable (P＞0.05).
Therefore, Chinese medicine additive pulvis of the present invention has obvious antiinflammatory action to the inflammation mouse; The guinea pig cough that citric acid is caused has obvious prolongation incubation period and reduces the effect of cough number of times; Obvious phlegm-dispelling functions is arranged; Rabbit after the vaccine pyrogenicity had the significant hypothermal effect; Staphylococcus aureus, Friedlanders bacillus and Respiratory Syncytial Virus(RSV) all there is inhibitory action, show by cough-relieving and the animal experiment that eliminates the phlegm: its outer being coated with and oral effect suitable (P＞0.05) of this Chinese medicine additive, and remarkable effect (P＜0.05) is all arranged.
Two. the pharmacology toxicity test
1, acute toxicity test
The application mouse carries out acute toxicity testing and shows: mouse oral administration gavage Chinese medicine additive granule of the present invention, under 488.8g crude drug/kg dosage, the light activity minimizing appears in mouse after the administration, recover normal about 1 hour, Continuous Observation is 7 days after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mouse oral administration gavage Chinese medicine additive of the present invention is 488.8g crude drug/kg/d (LD 50＞488.8g crude drug/kg).Chinese medicine additive clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Point out this medicine acute toxicity low, clinical drug safety.
2, long term toxicity test
Select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine additive pulvis of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, after the administration 90 days and carry out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and control group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range (NR), between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine additive of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescence observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
3, select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine additive powder of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, after the administration 90 days and carry out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and control group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range (NR), between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescence observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine additive clinical practice of the present invention higher.
Pharmacodynamic experiment
Egg bird flu symptom, full name bird class influenza is the zoonosis that is caused by virus, usually only infects birds, rare situation can infected pigs.The avian influenza virus height infects the people for specific species but can cross over the species obstacle in rare situation.The control of laying hen bird flu symptom: do not advance chicken from the bird flu epidemic-stricken area, prevent chicken and other birds, such as contacts such as duck, geese, do not allow chicken drink pond water.Suspect as early as possible censorship when having this disease to occur, the virulence of identifying virus and pathogenic, designated epidemic areas, the strict blockade slaughtered the chicken that all infect highly pathogenic virus.Hen house is carried out thorough disinfection, and vacant 2～4 all just standards are raised chickens again.The inactivated vaccine that the Prevalent district inoculation is made of local popular strain.Experimental animal and grouping
(1), experiment material:
1, animal: healthy 3 the monthly age reed catkins chicken, body weight (1.5 ± 0.4) kg, male and female have concurrently.Qingdao Agricultural University provides.
2, experimental drug:
Feed A: according to the chicken feed of method preparation of the present invention.Proportioning is: tryptophan 0.01-0.1 part, feed grade zeolite powder 5-10 part imitates U.S. plain 1-2 part, wheat bran 30-50 part, broken corn 10-20 part, fish meal 10-20 part, rice chaff 5-10 part, 1.5 parts of Chinese medicine additives.Concentrate drinking-water, once a day.
Feed B: the therapeutic scheme of avian influenza symptom: golden toadpoison loses+basal feed, Henan Si Purui animal pharmaceutical estate Co., Ltd provides: and golden toadpoison loses+and basal feed (1.3 gold medal toadpoisons lose jin/100 jin of basal feeds) concentrates spice together, and institute's spice amount was finished at 2---3 hour.Concentrate drinking-water, once a day.The basal feed proportioning is: tryptophan 0.01-0.1 part, feed grade zeolite powder 5-10 part imitates U.S. plain 1-2 part, wheat bran 30-50 part, broken corn 10-20 part, fish meal 10-20 part, rice chaff 5-10 part.
3, instrument: computer numeral clinical thermometer.
(2), experimental technique: get 24 of healthy reed catkins chickens, 3d before the experiment is 55%-65% at room temperature 22-25 ℃, humidity, and every interval was surveyed animal anus temperature in 1 hour 1 time totally 4 times under the ventilated environment, animal is adapted to, and select the animal of body temperature fluctuation range in 0.4 ℃ of scope for subsequent use.During experiment animal is divided into 3 groups at random by the body weight size, be respectively physiological saline group, A group, B group.Survey chicken anus temperature 1 time every 30min with the computer digital clinical thermometer, survey altogether 3 times, asking for its mean value is this animal basal body temperature.Press 1ml/kg to chicken auricular vein injection H 9N2 pyrogenicity.Surveyed respectively chicken anus temperature 5 times on 1,5,10th, 15 and 30 after pyrogenicity, the difference of each rear anus temperature of group man chicken day part treatment of calculating and basal body temperature takes statistics to learn and processes.
Feeding and management:
Conscientiously do feeding and management well, take enclosed breeding, be strictly on guard against that wild bird enters pouity dwelling place from door, window; Prevent that water source and feed are by the wild fowl fecal pollution; Regularly pouity dwelling place and surrounding environment are carried out disinfection, harmful insect and muroid in the poultry-farm are regularly eliminated in the sterilization of reinforcing band chicken; Dead bird must be burned or be buried.Perform the bird feeding and management, improve fowl resistance only, reduce the generation of stress factor as far as possible, note autumn and winter, the at the end of winter and the beginning of spring variation in season, carry out thermal insulation work; In time cleaning ight soil also can regularly use Chinese medicine preparation of the present invention at hen house, and stifling hen house reduces the stimulation of bad air, thereby reaches the incidence of disease that reduces respiratory diseases and enteron aisle disease.
(3), experimental result: the results detailed in Table 1.
Different period body temperature situations of change after each treated animal treatment of table 1
Figure BDA00002081896900151
(4), conclusion: as can be seen from Table 1, the result shows that the A group has obvious antipyretic effect to H9N2 pyrogenicity chicken, and its effect of bringing down a fever is better than the B group, and antipyretic effect is lasting than the B group.

Claims (10)

1. a chicken feed of preventing and treating bird flu is characterized in that, comprising: tryptophan, feed grade zeolite powder, the U.S. element of effect, wheat bran, broken corn, fish meal, rice chaff and Chinese medicine additive; The bulk drug of described Chinese medicine additive further comprises: the capsule of weeping forsythia, the Radix Astragali, Radix Codonopsis, golden cypress, the root of large-flowered skullcap, oriental wormwood, the fruit of Chinese magnoliavine, rhizoma atractylodis, Radix Isatidis, the bighead atractylodes rhizome, folium isatidis, schizonepeta, the red sage root, the root of herbaceous peony.
2. the chicken feed of described control bird flu according to claim 1, it is characterized in that, the ratio of weight and number of the various raw materials of described chicken feed is: tryptophan 0.01-0.1 part, feed grade zeolite powder 5-10 part imitates U.S. plain 1-2 part, wheat bran 30-50 part, broken corn 10-20 part, fish meal 10-20 part, rice chaff 5-10 part, Chinese medicine additive 1-2 part.
3. the chicken feed of described control bird flu according to claim 1, it is characterized in that, the ratio of weight and number of each bulk drug is in the described Chinese medicine additive: the capsule of weeping forsythia 10～20 weight portions, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions, the root of herbaceous peony 10～20 weight portions.
4. the chicken feed of described control bird flu according to claim 1, it is characterized in that, the ratio of weight and number of each bulk drug is in the described Chinese medicine additive: the capsule of weeping forsythia 10～15 weight portions, the Radix Astragali 10～15 weight portions, Radix Codonopsis 10～15 weight portions, golden cypress 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions and the root of herbaceous peony 10～20 weight portions.
5. one kind such as the preparation method of the Chinese medicine additive of the chicken feed of control bird flu as described in each in the claim 1～4, it is characterized in that, the formulation of described Chinese medicine additive is pulvis, and step is:
A. bulk drug is pulverized, crossed the 100-120 mesh sieve, collect the fine powder by sieve;
B. can not soak by the meal of sieve 1-2 hour input multi-function extractor extraction twice in the water, and add 5-10 times of water gaging for the first time and decocted 1-2 hour, add 4-8 times of water gaging decoction 1-2 hour for the second time, merge decocting liquid twice, filter to get filtrate; Heating is concentrated into pasty state, cools off after putting into 80 ℃ of oven dry of baking oven, grinds to form fine powder;
C. the fine powder that obtains in above-mentioned two steps is mixed.
6. one kind such as the preparation method of the Chinese medicine additive of the chicken feed of control bird flu as described in each in the claim 1～4, it is characterized in that, the formulation of described Chinese medicine additive is powder, step is: described bulk drug is mixed by proportioning, drop into pulverizer and pulverize, put into the acid and alkali-resistance infusion kettle, at normal temperatures, steeped 15～30 days with alcohol, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Leave standstill and then remove supernatant, the liquid that stays is put into oven for drying, makes fine powder.
7. the Chinese medicine additive that uses of a chicken feed, it is characterized in that, the ratio of weight and number of each bulk drug is: the capsule of weeping forsythia 10～20 weight portions, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions, the root of herbaceous peony 10～20 weight portions.
8. described Chinese medicine additive according to claim 7, it is characterized in that, the ratio of weight and number of each bulk drug is: the capsule of weeping forsythia 10～15 weight portions, the Radix Astragali 10～15 weight portions, Radix Codonopsis 10～15 weight portions, golden cypress 10～15 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～20 weight portions and the root of herbaceous peony 10～20 weight portions.
9. described Chinese medicine additive according to claim 7, it is characterized in that, the ratio of weight and number of each bulk drug is: the capsule of weeping forsythia 10～15 weight portions, the Radix Astragali 10～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 10～20 weight portions, the root of large-flowered skullcap 10～15 weight portions, oriental wormwood 10～15 weight portions, the fruit of Chinese magnoliavine 10～15 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 10～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 10～20 weight portions, schizonepeta 10～20 weight portions, the red sage root 10～15 weight portions, the root of herbaceous peony 10～15 weight portions.
10. described Chinese medicine additive according to claim 7, it is characterized in that, the ratio of weight and number of each bulk drug is: the capsule of weeping forsythia 15～20 weight portions, the Radix Astragali 15～20 weight portions, Radix Codonopsis 10～20 weight portions, golden cypress 15～20 weight portions, the root of large-flowered skullcap 15～20 weight portions, oriental wormwood 10～20 weight portions, the fruit of Chinese magnoliavine 10～20 weight portions, rhizoma atractylodis 10～20 weight portions, Radix Isatidis 15～20 weight portions, the bighead atractylodes rhizome 10～20 weight portions, folium isatidis 15～20 weight portions, schizonepeta 15～20 weight portions, the red sage root 15～20 weight portions, the root of herbaceous peony 15～20 weight portions.
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CN103734548A (en) * 2014-01-27 2014-04-23 山东新希望六和集团有限公司 Feedstuff for treating swine dyspepsia and preparation method thereof
CN103875943A (en) * 2014-02-24 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens in later period of egg laying
CN103875944A (en) * 2014-02-24 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens in middle of egg laying period
CN103875954A (en) * 2014-02-22 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens at age of 9-18 weeks in growth period
CN104770563A (en) * 2014-01-09 2015-07-15 李先奇 Novel pollutant-free fertilizer additive
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CN105410429A (en) * 2015-11-05 2016-03-23 农鑫高科（北京）科技开发有限公司 Winter cold preventing and curing chicken feed and preparation method thereof
CN105981984A (en) * 2016-03-07 2016-10-05 倪皖生 Layer feed capable of preventing avian influenza and preparation method thereof
CN106614363A (en) * 2016-12-29 2017-05-10 郝天伟 Novel technique of Gallus domestiaus breeding
CN107494988A (en) * 2017-10-24 2017-12-22 黄石晨科饲料科技有限公司 A kind of egg feedstuff of the pre- avian influenza-prevention of energy
CN107637451A (en) * 2017-11-01 2018-01-30 广西吉朋投资有限公司 A kind of rice leaf folder and the Ecological preventive way of snout moth's larva
CN107787916A (en) * 2017-10-28 2018-03-13 蚌埠宏瑞园林有限公司 A kind of cultural method for preventing duckling infectious serositis
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CN110368394A (en) * 2019-06-25 2019-10-25 华中农业大学 A kind of avilamycin inhibits the application in drug in pig C.perfringens
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CN103120267A (en) * 2013-02-28 2013-05-29 灵山县园丰牧业有限公司 Feed for lingshan patridge chicken
CN104770563A (en) * 2014-01-09 2015-07-15 李先奇 Novel pollutant-free fertilizer additive
CN103734548A (en) * 2014-01-27 2014-04-23 山东新希望六和集团有限公司 Feedstuff for treating swine dyspepsia and preparation method thereof
CN103875954A (en) * 2014-02-22 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens at age of 9-18 weeks in growth period
CN103875943A (en) * 2014-02-24 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens in later period of egg laying
CN103875944A (en) * 2014-02-24 2014-06-25 安徽鲲鹏农业科技有限公司 Formula of feed of laying hens in middle of egg laying period
CN104958341B (en) * 2015-07-06 2018-08-31 河北普德动物药业有限公司 A kind of Radix Codonopsis cauline leaf extractive from fermentative and its preparation method and application
CN104958341A (en) * 2015-07-06 2015-10-07 河北普德动物药业有限公司 Codonopsis pilosula stem and leaf fermented extract as well as preparation method and application thereof
CN105410429A (en) * 2015-11-05 2016-03-23 农鑫高科（北京）科技开发有限公司 Winter cold preventing and curing chicken feed and preparation method thereof
CN105981984A (en) * 2016-03-07 2016-10-05 倪皖生 Layer feed capable of preventing avian influenza and preparation method thereof
CN106614363A (en) * 2016-12-29 2017-05-10 郝天伟 Novel technique of Gallus domestiaus breeding
CN107494988A (en) * 2017-10-24 2017-12-22 黄石晨科饲料科技有限公司 A kind of egg feedstuff of the pre- avian influenza-prevention of energy
CN107787916A (en) * 2017-10-28 2018-03-13 蚌埠宏瑞园林有限公司 A kind of cultural method for preventing duckling infectious serositis
CN107637451A (en) * 2017-11-01 2018-01-30 广西吉朋投资有限公司 A kind of rice leaf folder and the Ecological preventive way of snout moth's larva
CN110368394A (en) * 2019-06-25 2019-10-25 华中农业大学 A kind of avilamycin inhibits the application in drug in pig C.perfringens
CN111588801A (en) * 2020-06-09 2020-08-28 元亨生物技术有限公司 Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof
CN111588801B (en) * 2020-06-09 2021-10-01 元亨生物技术有限公司 Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof

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