CN103202880A - Medicine for treating allergic rhinitis and method for preparing medicine - Google Patents
Medicine for treating allergic rhinitis and method for preparing medicine Download PDFInfo
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Abstract
The invention discloses medicine for treating allergic rhinitis and a method for preparing the medicine. The medicine comprises, by weight, 16-20 parts of astragalus, 14-16 parts of fried fructus xanthii, 14-16 parts of flos magnoliae, 10-14 parts of bighead atractylodes rhizome, 8-12 parts of angelica dahurica, 10-14 parts of cicada slough, 6-10 parts of salvia miltiorrhiza, 6-10 parts of licorice, 11-13 parts of sucrose powder and 1-3 parts of dextrin which are manufactured into grains. The method includes extracting volatile oil, mixing raw materials; adding the raw materials into water and soaking the raw materials in the water; and decocting the raw materials in the water, and the like so as to obtain a finished product. The medicine and the method have the advantages that the medicine is granular preparation, can be taken conveniently, is portable, is low in cost and can realize effects of tonifying qi, strengthening exterior, dispelling coldness, eliminating pathogens, dredging channels and promoting blood circulation, symptoms such as nasal obstruction, rhinocnesmus, sneezing and rhinorrhoea caused by the allergic rhinitis can be effectively improved, a curative effect is persistent, and the total effective rate can reach 90% at least as shown by observation for clinical effects.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of of allergic rhinitis, specifically be a kind of be the medicine of the allergic rhinitis made of raw material with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Allergic rhinitis claims allergic rhinitis again, is that human body increases some anaphylactogen sensitivity and cause that it is main a kind of allergic disease that nasal mucosa edema, mucosa gland hypertrophy and epithelium oxyphil cell are soaked into.Clinical symptoms mainly shows as paroxysmal sneeze, clear water sample nasal mucus, and nasal obstruction and rhinocnesmus, part is with hyposmia.The suddenly normal and outbreak repeatedly of allergic rhinitis, protracted course of disease, meeting appreciable impact patient's quality of life, and can bring out allergic asthma, sinusitis, otitis media etc. than serious disease.Allergic rhinitis can extensively betide child and adult, and at present should the disease sickness rate on the rise.
Doctor trained in Western medicine is used Claritin always at present, and Drug therapys such as topical application glucocorticoid are relief of symptoms temporarily, can not eradicate the cause of disease, can not obtain the effect for the treatment of both the principal and the secondary aspects of a disease at the same time, and various side effect appear in medicines such as life-time service antiallergic and hormone easily.Local microwave or laser therapy have damage to nasal membrane.Desensitization treatment is long the course for the treatment of, and is costly, and curative effect can not be satisfactory.
Allergic rhinitis belongs to Chinese medicine " allergic rhinitis " category.Chinese medicine thinks that the pathogenesis of allergic rhinitis mainly is owing to patient's deficiency of vital energy instability of surface, the imbalance of lung spleen renal function, causes invading in the pathogenic wind-cold institute and causes.State of an illness delay repeatedly, disease such as often show as vital QI being weakened and pathogen being violent or deficiency and excess and see.Control based on strengthening vital QI to eliminate pathogenic factors, expelling wind and cold, a surname's clearing the nasal passage, assistant is with invigorating QI to consolidate the body surface resistance.
Treatment by Chinese herbs allergic rhinitis clinical observation short treating period, rapid-action, evident in efficacy, safe and reliable, can reach the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.But the Chinese medicine ingredients of existing treatment of allergic rhinitis is complicated and mostly be decoction, and patient uses inconvenience, and the effective ingredient in many medicines is owing to the error of decocting method is run off, thereby has reduced drug effect.Dosage forms such as some drop pill can be alleviated patient's symptom at short notice, but can't play the purpose of radical cure.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind for the treatment of of allergic rhinitis, this medicine is crude drug with Chinese medicine, have benefit defend consolidating superficial resistance, cold expelling eliminating evil sensible, invigorate blood circulation, the antianaphylactic effect of antiinflammatory, the treatment of allergic rhinitis effect is remarkable, medicine of the present invention is granule, and taking convenience is easy to carry.
Another object of the present invention provides the preparation method of the medicine of this treatment of allergic rhinitis.
Concrete technical scheme of the present invention is as follows:
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 16-20 part, Fructus Xanthii (parched) 14-16 part, Flos Magnoliae 14-16 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Angelicae Dahuricae 8-12 part, Periostracum Cicadae 10-14 part, Radix Salviae Miltiorrhizae 6-10 part, Radix Glycyrrhizae 6-10 part, cane sugar powder 11-13 part, dextrin 1-3 part.
Preferably, its raw material components of medicine of the present invention is counted by weight: 18 parts of the Radixs Astragali, 15 parts of Fructus Xanthii (parched)s, 15 parts of Flos Magnoliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radixs Angelicae Dahuricae, 12 parts of Periostracum Cicadaes, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 3 parts in dextrin.
Above-mentioned medicine is street drug.
The sweet temperature of the Radix Astragali in the medicine of the present invention, tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, the gas of spleen reinforcing lung; The little hardship of Fructus Xanthii acrid in the mouth, slightly poisonous, warm in nature dry, dispersing wind-cold, removing dampness is turbid, clearing the nasal passage, except nasal obstruction, and double pain relieving; The Radix Astragali and Fructus Xanthii are monarch drug altogether.The Rhizoma Atractylodis Macrocephalae is sweet, bitter, and is warm in nature, and the Rhizoma Atractylodis Macrocephalae can invigorating the spleen and benefiting QI, benefiting QI for strengthening the superficies, with Radix Astragali compatibility, can increase the defense function that lung is defended; The hot temperature of Flos Magnoliae is dispersed, and fragrant saturating key reaches on its property, rises to reach clearing heat in QI system, and the merit of diffusing ailment said due to cold or exposure, clearing the nasal passage is arranged, and for controlling wanting of nasal sinusitis, Flos Magnoliae and Fructus Xanthii have synergism, and the toxicity of Fructus Xanthii is reduced and effect such as antiinflammatory enhancing to some extent; The hot temperature of the Radix Angelicae Dahuricae, but dispersing wind-cold, expelling pathogenic wind from the body surface, pain relieving, clearing the nasal passage, dampness leukorrhagia stopping.The three is ministerial drug altogether.The Periostracum Cicadae sweet in the mouth is cold in nature, kind clearing the nasal passage, dispelling wind and heat pathogens, eliminating evil inducing sweat; Radix Salviae Miltiorrhizae is bitter and be slightly cold, and activating blood and removing stasis and just not hindering can recover the normal physiological function of QI and blood, and lung is defended effect and strengthened; Periostracum Cicadae and Radix Salviae Miltiorrhizae are adjuvant drug altogether.Radix Glycyrrhizae is sweet flat, reinforcing the heart temper, and detoxifcation, coordinating the actions of various ingredients in a prescription is for making medicine.
Modern pharmacology studies show that the Radix Astragali has the effect of two-ways regulation immunologic function, and humoral immune function is had facilitation, can improve the hypersensitive state in the allergic disease patient body, and the immunity by enhancing body reaches anti-allergic effects.Fructus Xanthii has effects such as antiinflammatory, antiallergic, antibiotic, antiviral, antihistamine and acetylcholine.The Rhizoma Atractylodis Macrocephalae has regulates immunologic function, effect such as antibiotic.Flos Magnoliae has effects such as antiinflammatory, antiallergic, antihistamine and acetylcholine, and can suppress the generation of inflammatory mediator, reduces the inflammatory tissue capillary permeability, suppresses the inflammatory swelling effect.Periostracum Cicadae has stronger anti-allergic effects.Radix Salviae Miltiorrhizae contains TANSHINONES first, TANSHINONES second, TANSHINONES third, also contain Vit E, effects such as blood circulation promoting and blood stasis dispelling, detumescence, sensible, antiinflammatory, antiallergic are arranged, Radix Salviae Miltiorrhizae can improve nasal cavity local vascular permeability, alleviate mucosa and submucous tissue edema, alleviate the turbinate mucosa tissue to allergenic stress.
Compared with prior art, it is high and have the medicine of side effect that the present invention has removed some drug effects, only keeps above ten kinds of former medicines, and have good curative effect.More than ten kinds of medicines can promote humoral immune function after share, improve the hypersensitive state in the allergic disease patient body, enhancing human body immunity power, and the effect with antiinflammatory, antiallergic, antibiotic, antiviral, antihistamine and acetylcholine, can suppress the generation of inflammatory mediator, reduce the inflammatory tissue capillary permeability, suppress inflammatory swelling, can also blood circulation promoting and blood stasis dispelling, detumescence, sensible, improve nasal cavity local vascular permeability, alleviate mucosa and submucous tissue edema, alleviate the turbinate mucosa tissue to allergenic stress.
Medicine of the present invention is granule, and taking convenience is easy to carry.
The above-mentioned raw materials medicine prepares the method for medicine of the present invention, and concrete steps comprise:
A. extract volatile oil than with Fructus Xanthii (parched), Flos Magnoliae with steam distillation by set of dispense, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae, Periostracum Cicadae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae being mixed by the set of dispense ratio, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, add the water that total mixture gross weight 7-8 doubly measures then, soak and begin after 0.5 hour to decoct, temperature control is at 150-170 ℃, and decocting time is: 1.5-2 hour; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water that gross weight 4-6 doubly measures, and carry out decocting the second time, and temperature is controlled at 150-170 ℃, and decocting time is 1-1.5 hour, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, in thick paste, adds cane sugar powder, dextrin according to the set of dispense ratio, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Preferably, the water yield that adds among the described step b is 8 times of total mixture gross weights, and temperature control is at 160 ℃ during decoction, and decocting time is: 2 hours.
Preferably, 6 times of the medicinal residues gross weights that the water yield that adds among the described step c is filtered the back gained for step b, temperature control is at 160 ℃ during decoction, and decocting time is: 1.5 hours.
Preferably, gained thick paste relative density at room temperature is in the described steps d: 1.35-1.39.
Be rich in volatile oil in Fructus Xanthii and the Flos Magnoliae, and volatile oil is the important active ingredient of two kinds of Chinese medicines.Contain tens of kinds of effective pharmacology compositions in the Fructus Xanthii (parched) volatile oil, comprise olefine aldehydr, valeral, caproic acid, alkanes etc.; The effective pharmaceutical component of kind comprises bis-epoxy lignanoid surplus containing 200 in the Flos Magnoliae volatile oil, ethers, and alcohols, the numerous organic principles of alkene class have effects such as tangible antiinflammatory antiallergic action.Volatile oil can be with vapor distillation; take the method for long-time decocting and concentrating can lose effective pharmacology composition in the volatile oil fully merely; therefore extract the volatile oil of Fructus Xanthii (parched) and Flos Magnoliae earlier; afterwards medicinal residues are decocted with other medicines; and then with volatile oil and granule mixing; can fully extract and keep the effective ingredient of medicine, improve the curative effect of this medicine.
Adopt the various raw materials of said components proportioning, combine the drug effect of the Chinese medicine of respectively distinguishing the flavor of, reasonably collocation makes the more thorough of drug effect performance, the counteracting of the drug effect between Chinese medicine of having prevented from simultaneously respectively distinguishing the flavor of.Use modern pharmacology, medicine of the present invention is carried out pharmacodynamic study, medicine of the present invention has the immunity function of enhancing, antiinflammatory action, bacteriostasis.Because the cost of various raw materials is lower, be fit to large-scale production, made things convenient for more patients' use.
Medicine of the present invention have benefit defend consolidating superficial resistance, cold expelling eliminating evil sensible, invigorate blood circulation, can effectively improve symptoms such as nasal obstruction that allergic rhinitis causes, rhinocnesmus, sneeze, watery nasal discharge, and curative effect is lasting.Medicine of the present invention can be adjusted the allomeric function of Allergic Rhinitis, adjusts body's immunological function, has the effect of antiallergic and antiinflammatory, can improve symptom rapidly, giving consideration to both the incidental and fundamental, and curative effect is lasting, has no adverse reaction, and can effectively reduce relapse rate.Medicine of the present invention is granule, and taking convenience is easy to carry.Through clinical observation on the therapeutic effect, total effective rate can reach more than 90%.
The specific embodiment
Embodiment 1
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 160g, Fructus Xanthii (parched) 140g, Flos Magnoliae 140g, Rhizoma Atractylodis Macrocephalae 100g, Radix Angelicae Dahuricae 80g, Periostracum Cicadae 100g, Radix Salviae Miltiorrhizae 60g, Radix Glycyrrhizae 60g, cane sugar powder 110g, dextrin 10g.
Prepare the method for the medicine of described treatment of allergic rhinitis, concrete steps comprise:
A. 140g Fructus Xanthii (parched), 140g Flos Magnoliae are extracted volatile oil with steam distillation, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the 160g Radix Astragali, 140g Fructus Xanthii (parched), the 100g Rhizoma Atractylodis Macrocephalae, the 80g Radix Angelicae Dahuricae, 100g Periostracum Cicadae, 60g Radix Salviae Miltiorrhizae, 60g Radix Glycyrrhizae being mixed, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, the water that adds 7 times of amounts of total mixture gross weight then, soak and begin after 0.5 hour to decoct, temperature control is at 150 ℃, and decocting time is: 1.5 hours; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water of 4 times of amounts of gross weight, carry out decocting the second time, and temperature is controlled at 150 ℃, and decocting time is 1 hour, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, the relative density 1.36 of gained thick paste under the room temperature adds 110g cane sugar powder, 10g dextrin in thick paste, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Embodiment 2
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 200g, Fructus Xanthii (parched) 160g, Flos Magnoliae 160g, Rhizoma Atractylodis Macrocephalae 140g, Radix Angelicae Dahuricae 120g, Periostracum Cicadae 140g, Radix Salviae Miltiorrhizae 100g, Radix Glycyrrhizae 100g, cane sugar powder 130g, dextrin 30g.
Prepare the method for the medicine of described treatment of allergic rhinitis, concrete steps comprise:
A. 160g Fructus Xanthii (parched), 160g Flos Magnoliae are extracted volatile oil with steam distillation, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the 200g Radix Astragali, 160g Fructus Xanthii (parched), the 140g Rhizoma Atractylodis Macrocephalae, the 120g Radix Angelicae Dahuricae, 140g Periostracum Cicadae, 100g Radix Salviae Miltiorrhizae, 100g Radix Glycyrrhizae being mixed, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, the water that adds 8 times of amounts of total mixture gross weight then, soak and begin after 0.5 hour to decoct, temperature control is at 170 ℃, and decocting time is: 1.5 hours; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water of 4 times of amounts of gross weight, carry out decocting the second time, and temperature is controlled at 150 ℃, and decocting time is 1 hour, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, the relative density 1.37 of gained thick paste under the room temperature adds 130g cane sugar powder, 30g dextrin in thick paste, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Embodiment 3
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 170g, Fructus Xanthii (parched) 150g, Flos Magnoliae 150g, Rhizoma Atractylodis Macrocephalae 110g, Radix Angelicae Dahuricae 90g, Periostracum Cicadae 110g, Radix Salviae Miltiorrhizae 70g, Radix Glycyrrhizae 70g, cane sugar powder 120g, dextrin 20g.
Prepare the method for the medicine of described treatment of allergic rhinitis, concrete steps comprise:
A. 150g Fructus Xanthii (parched), 150g Flos Magnoliae are extracted volatile oil with steam distillation, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the 170g Radix Astragali, 150g Fructus Xanthii (parched), the 110g Rhizoma Atractylodis Macrocephalae, the 90g Radix Angelicae Dahuricae, 110g Periostracum Cicadae, 70g Radix Salviae Miltiorrhizae, 70g Radix Glycyrrhizae being mixed, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, the water that adds 7 times of amounts of total mixture gross weight then, soak and begin after 0.5 hour to decoct, temperature control is at 155 ℃, and decocting time is: 1.5 hours; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water of 4 times of amounts of gross weight, carry out decocting the second time, and temperature is controlled at 155 ℃, and decocting time is 1 hour, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, the relative density 1.35 of gained thick paste under the room temperature adds 120g cane sugar powder, 20g dextrin in thick paste, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Embodiment 4
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 190g, Fructus Xanthii (parched) 150g, Flos Magnoliae 150g, Rhizoma Atractylodis Macrocephalae 130g, Radix Angelicae Dahuricae 110g, Periostracum Cicadae 130g, Radix Salviae Miltiorrhizae 90g, Radix Glycyrrhizae 90g, cane sugar powder 120g, dextrin 30g.
Prepare the method for the medicine of described treatment of allergic rhinitis, concrete steps comprise:
A. 150g Fructus Xanthii (parched), 150g Flos Magnoliae are extracted volatile oil with steam distillation, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the 190g Radix Astragali, 150g Fructus Xanthii (parched), the 130g Rhizoma Atractylodis Macrocephalae, the 110g Radix Angelicae Dahuricae, 130g Periostracum Cicadae, 90g Radix Salviae Miltiorrhizae, 90g Radix Glycyrrhizae being mixed, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, the water that adds 8 times of amounts of total mixture gross weight then, soak and begin after 0.5 hour to decoct, temperature control is at 165 ℃, and decocting time is: 1.5 hours; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water of 6 times of amounts of gross weight, carry out decocting the second time, and temperature is controlled at 165 ℃, and decocting time is 1.5 hours, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, the relative density 1.38 of gained thick paste under the room temperature adds 120g cane sugar powder, 30g dextrin in thick paste, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Embodiment 5
A kind of medicine for the treatment of of allergic rhinitis, its raw material components is counted by weight: Radix Astragali 180g, Fructus Xanthii (parched) 150g, Flos Magnoliae 150g, Rhizoma Atractylodis Macrocephalae 120g, Radix Angelicae Dahuricae 100g, Periostracum Cicadae 120g, Radix Salviae Miltiorrhizae 80g, Radix Glycyrrhizae 80g, cane sugar powder 120g, dextrin 30g.
Prepare the method for the medicine of described treatment of allergic rhinitis, concrete steps comprise:
A. 150g Fructus Xanthii (parched), 150g Flos Magnoliae are extracted volatile oil with steam distillation, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the 180g Radix Astragali, 150g Fructus Xanthii (parched), the 120g Rhizoma Atractylodis Macrocephalae, the 100g Radix Angelicae Dahuricae, 120g Periostracum Cicadae, 80g Radix Salviae Miltiorrhizae, 80g Radix Glycyrrhizae being mixed, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, the water that adds 8 times of amounts of total mixture gross weight then, soak and begin after 0.5 hour to decoct, temperature control is at 160 ℃, and decocting time is: 1.5 hours; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water of 6 times of amounts of gross weight, carry out decocting the second time, and temperature is controlled at 160 ℃, and decocting time is 1.5 hours, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, the relative density 1.39 of gained thick paste under the room temperature adds 120g cane sugar powder, 30g dextrin in thick paste, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
Comparative example
Prepared medicine and cocklebur fruit drop-pills for treating rhinitis among above-described embodiment 1-5 (production of Sichuan He Run pharmaceutical Co. Ltd) are carried out the efficient test for the treatment of of allergic rhinitis.For showing medicine of the present invention to the therapeutic effect of allergic rhinitis, select 206 routine Allergic Rhinitis to carry out clinical observation on the therapeutic effect altogether, male's 115 examples wherein, women's 91 examples, age characteristics is in 18-60 year.Be divided into six groups at random.Wherein five groups is the embodiment group, and one group is matched group.The oral medicine of the present invention of embodiment group, each 10g, every day 3 times; Matched group clothes cocklebur fruit drop-pills for treating rhinitis (production of Sichuan He Run pharmaceutical Co. Ltd), 28 balls, 3 times on the one.Every group equal 10 days be a course for the treatment of.
Criterion of therapeutical effect is as follows:
Produce effects: clinical symptom disappearance such as nasal obstruction, rhinocnesmus, sneeze and snivel, the bronchia mucosal inspection is normal; Effectively: clinical symptoms and sign alleviate during outbreak, and attack times reduces, but the intermission prolongation, and the bronchia mucosal edema alleviates; Invalid: symptom and sign do not have obvious improvement, and the patient shows effect often.Add up to effectively total with the above two.The results are shown in Table 1.
Table 1
Specimen types | Produce effects | Effectively | Invalid | Total effective rate (%) |
Embodiment 1 | 8 | 22 | 3 | 90.9 |
Embodiment 2 | 9 | 22 | 2 | 93.9 |
Embodiment 3 | 12 | 20 | 2 | 94.1 |
Embodiment 4 | 11 | 21 | 3 | 91.4 |
Embodiment 5 | 13 | 21 | 2 | 94.4 |
Cocklebur fruit drop-pills for treating rhinitis | 4 | 23 | 9 | 75 |
From table 1 result as can be seen, the total effective rate of embodiment group is better than matched group, the more existing medicine curative effect of the medicine of visible treatment of allergic rhinitis provided by the present invention is enhanced, total effective rate can reach more than 90%.
Claims (7)
1. the medicine of a treatment of allergic rhinitis, it is characterized in that: its raw material components is counted by weight: Radix Astragali 16-20 part, Fructus Xanthii (parched) 14-16 part, Flos Magnoliae 14-16 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Angelicae Dahuricae 8-12 part, Periostracum Cicadae 10-14 part, Radix Salviae Miltiorrhizae 6-10 part, Radix Glycyrrhizae 6-10 part, cane sugar powder 11-13 part, dextrin 1-3 part.
2. the medicine for the treatment of of allergic rhinitis according to claim 1, it is characterized in that: its raw material components is counted by weight: 18 parts of the Radixs Astragali, 15 parts of Fructus Xanthii (parched)s, 15 parts of Flos Magnoliaes, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radixs Angelicae Dahuricae, 12 parts of Periostracum Cicadaes, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 3 parts in dextrin.
3. the medicine for the treatment of of allergic rhinitis according to claim 1 and 2, it is characterized in that: described medicine is granule.
4. the preparation method of the medicine of claim 1 or 2 described treatment of allergic rhinitis, it is characterized in that: concrete steps comprise:
A. extract volatile oil than with Fructus Xanthii (parched), Flos Magnoliae with steam distillation by set of dispense, collect Fructus Xanthii (parched) and Flos Magnoliae volatile oil respectively;
B. after the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae, Periostracum Cicadae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae being mixed by the set of dispense ratio, add Fructus Xanthii (parched) behind the described extraction volatile oil of step a and Flos Magnoliae medicinal residues mix total mixture, add the water that total mixture gross weight 7-8 doubly measures then, soak and begin after 0.5 hour to decoct, temperature control is at 150-170 ℃, and decocting time is: 1.5-2 hour; Filter, get filtrate and medicinal residues;
C. the medicinal residues that step b filtered the back gained add the water that gross weight 4-6 doubly measures, and carry out decocting the second time, and temperature is controlled at 150-170 ℃, and decocting time is 1-1.5 hour, filters, and gets filtrate, with the filtrate merging of this filtrate and step b gained;
D. the filtrate after merging among the step c is condensed into thick paste, in thick paste, adds cane sugar powder, dextrin according to the set of dispense ratio, make granule behind the mixing, drying, granulate;
E. the Fructus Xanthii (parched) that step a is made and Flos Magnoliae volatile oil are dissolved in and make mixed liquor in the ethanol, with nebulizer mixed liquor are sprayed on the granule that steps d makes equably, and mix homogeneously namely gets final products.
5. preparation method according to claim 4, it is characterized in that: the water yield that adds among the described step b is 8 times of total mixture gross weights, and temperature control is at 160 ℃ during decoction, and decocting time is: 2 hours.
6. preparation method according to claim 4 is characterized in that: 6 times of the medicinal residues gross weights that the water yield that adds among the described step c is filtered the back gained for step b, and temperature control is at 160 ℃ during decoction, and decocting time is: 1.5 hours.
7. preparation method according to claim 4, it is characterized in that: gained thick paste relative density at room temperature is in the described steps d: 1.35-1.39.
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CN104435122A (en) * | 2014-11-27 | 2015-03-25 | 王利华 | Traditional Chinese medicine lotion for treating anaphylactic rhinitis |
CN105311268A (en) * | 2014-07-02 | 2016-02-10 | 李一圣 | Compound traditional Chinese medicine for treating allergic rhinitis and preparation method thereof |
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CN103599200B (en) * | 2013-11-19 | 2015-04-29 | 太和县中医院 | Traditional Chinese medicine for treating chronic sinusitis |
CN105311268A (en) * | 2014-07-02 | 2016-02-10 | 李一圣 | Compound traditional Chinese medicine for treating allergic rhinitis and preparation method thereof |
CN104435122A (en) * | 2014-11-27 | 2015-03-25 | 王利华 | Traditional Chinese medicine lotion for treating anaphylactic rhinitis |
CN106074883A (en) * | 2016-08-05 | 2016-11-09 | 王豪鹏 | Ginseng stilbene antiallergic rhinitis particle and preparation method thereof |
CN106074883B (en) * | 2016-08-05 | 2020-01-14 | 新疆金世康药业有限公司 | Ginseng and astragalus anti-allergic rhinitis granules and preparation method thereof |
CN110721219A (en) * | 2019-12-06 | 2020-01-24 | 上海市宝山区中西医结合医院(上海中医药大学附属曙光医院宝山分院) | Traditional Chinese medicine for treating allergic rhinitis |
CN110946900A (en) * | 2020-01-02 | 2020-04-03 | 李欣倩 | Qi-tonifying cold-dispelling decoction for allergic rhinitis |
CN112472783A (en) * | 2020-12-29 | 2021-03-12 | 蒋旭艳 | Medicine for treating rhinitis and preparation method thereof |
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