CN105031282A - Medicine used for treating infantile hip joint dropsy and preparation method thereof - Google Patents
Medicine used for treating infantile hip joint dropsy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses medicine used for treating infantile hip joint dropsy and a preparation method thereof. The medicine is prepared from beefwood-like clubmoss herbs, trifoliate acanthopanax roots, curious kadsura root stems, brooklet anemone roots, boenninghausenia albiflora, radix melastomae, denseflower bulbophyllum herbs, griffith woodsorrel herbs, oplismenus compositus, semiliquidambar cathayensis, diploclisia affinis, caesalpinia cucullata, callicarpa longissima, cinnamomum glanduliferum nees, piper sarmentosum, scallion roots, diversifolious pimpinella herbs, asarum insignia, atropanthe sinensis roots, broadleaf ainsliaea herbs, common microtoena herbs, aconitum fischeri peichb, tali falsehellebore roots, pararuellia delavayana, homalocladium platycladum, dicranostigma leptopodum, acmella ciliata, holly bark, scented daphne leaves, corallodiscus flabellata, lindera megaphylla, syneilesis aconitifolia, three-leaved pronephrium herbs, rust-colored crotalaria herbs with roots, hovenia dulcis thunb, spina date seeds and heracleum hemsleyanum diels. The medicine has the advantages that when used for treating infantile hip joint dropsy, the medicine is good and definite in treatment effect, takes effect fast and has the effects of relaxing the muscles and stimulating the blood circulation, expelling wind and removing cold, eliminating swelling and alleviating pain and tonifying middle-Jiao and Qi for a patient, the purposes of treating both symptoms and root causes and improving the condition of the patient are achieved by performing macroscopic conditioning and microcosmic improvement on a basal body from inside to outside, and no toxic and side effect exists.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly a kind ofly treat medicine of infant hip joint hydrops and preparation method thereof.
Background technology
Hydrarthrosis belongs to synovitis, and synovitis is that synovial membrane is upset generation inflammation, causes juice to lack of proper care and forms a kind of arthropathy of hydrops.Synovial cell's secreting liquid, can lubricate and nourish joint, and the heat energy that during body movement, joint produces entirely relies in synovial fluid and blood circulation thereof and distributed.When joint affects by outwardness and inwardness factor, synovial membrane reacts, and causes hyperemia or edema, and liquid body exudate, show as arthroncus, pain, function is by obstacle.Also can say that articular cavity has hydrops, just has synovial membrane inflammation.
Hip joint synovitis is again hip joint transient (temporary) synovitis.3-10 year below child easily suffer from hip joint synovitis, wherein more common with male, the morbidity of most of infant is suddenly.Onset peak 3 ~ 6 years old, R)L, what bilateral hip joint was fallen ill accounts for 5%.
Synovitis is the aseptic inflammation because microcirculation does not freely cause, and cardinal symptom produces hydrops.
The diagnosis of hip joint hydrops: showing as groin place has tenderness, and hip joint flexing, adduction are limited, lower limb are slightly in abduction, outward turning shape, gait is slowly walked lamely, and hurries up and then walks lamely obviously, in flat bed, health ajusts visible pelvic inclination, and two lower limbs are uneven in length, can have suffering limb 0.5-2cm longer than strong limb.When active and passive adduction, outward turning hip joint, pain increases the weight of.Using ultrasound can check out hydrops and the lesions of synovium contributed of hip joint.The X-ray inspection of hip joint synovitis, main manifestations is capsula articularis coxae shade bulge, and when arthroedema is serious, visible femoral head is shifted laterally, and joint space is broadening.A small amount of long T1 is seen, long T2 hydrops shadow in magnetic resonance examination hip joint space.
For hip joint hydrops, there are some Therapeutic Method, but due to for child, adopt the Therapeutic Method of some operations and doctor trained in Western medicine, the side effect on some healths is easily caused to children's, injection of medicine cumulative toxicity, and other untoward reaction, therefore, adopt the Therapeutic Method of the traditional Chinese medical science, have very large advantage.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of medicine and preparation method for the treatment of infant hip joint hydrops, and treatment infant hip joint hydrops, reaches good curative effect object.
For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of infant hip joint hydrops, described medicine comprises following raw medicinal material: Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae, Herba Melastomatis dodecandri, Herba Bulbophylli Odoratissim, Herba Lysimachiae Insignis, Radix et Rhizoma Dispori Cantoniensis, Pterospermi Heterophylli, RADIX DIPLOCCISIAE, Radix Zanthoxyli Spinifolii, Caulis te Folium Callicarpae Longissimae, smelly Camphor tree, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix Allii Fistulosi, Herba pimpinellae diversifoliae, Herba Colei Pumili, it fluffy daughter root, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis, Herb Pararuelliae delavayanae, Herba Homalocladii Platycladii, Herba Dicranostigmatis Leptopodi, Herba Spilanthis Acmellae, Cortex Ilicis Rotundae, Folium daphnes odorae, Herba Corallodisci Flabellati, Lindera megaphylla, Herba Syneilesis Aconitifoliae, Herba pronephrii triphylli, Herba Crotalariae Ferrugineae, Semen Hoveniae (Fructus Hoveniae), Semen Ziziphi Spinosae and white JIUGUNIU.
Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 10-25 weight portion, Radix Acanthopanacis Trifoliati 13-24 weight portion, Radix seu Caulis Kadsurae Heteroclitae 12-20 weight portion, Radix Anemones Rivularis 3-5 weight portion, Herba Boenninghauseniae Albiflorae 10-20 weight portion, Herba Melastomatis dodecandri 15-20 weight portion, Herba Bulbophylli Odoratissim 15-23 weight portion, Herba Lysimachiae Insignis 10-20 weight portion, Radix et Rhizoma Dispori Cantoniensis 15-24 weight portion, Pterospermi Heterophylli 16-25 weight portion, RADIX DIPLOCCISIAE 10-20 weight portion, Radix Zanthoxyli Spinifolii 8-15 weight portion, Caulis te Folium Callicarpae Longissimae 12-20 weight portion, smelly Camphor tree 10-18 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 5-10 weight portion, Radix Allii Fistulosi 15-22 weight portion, Herba pimpinellae diversifoliae 10-20 weight portion, Herba Colei Pumili 2-4 weight portion, it fluffy daughter root 1-3 weight portion, Herba Ainsliaeae Latifoliae 15-20 weight portion, Herba Pogostemonis 10-20 weight portion, Radix Aconiti Coreani 2-4 weight portion, Radix Veratri Taliensis 1-3 weight portion, Herb Pararuelliae delavayanae 10-20 weight portion, Herba Homalocladii Platycladii 15-20 weight portion, Herba Dicranostigmatis Leptopodi 1-3 weight portion, Herba Spilanthis Acmellae 15-25 weight portion, Cortex Ilicis Rotundae 10-20 weight portion, Folium daphnes odorae 15-25 weight portion, Herba Corallodisci Flabellati 10-20 weight portion, Lindera megaphylla 8-15 weight portion, Herba Syneilesis Aconitifoliae 10-20 weight portion, Herba pronephrii triphylli 8-15 weight portion, Herba Crotalariae Ferrugineae 10-20 weight portion, Semen Hoveniae (Fructus Hoveniae) 12-25 weight portion, Semen Ziziphi Spinosae 10-20 weight portion and white JIUGUNIU 15-20 weight portion.
Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 10-20 weight portion, Radix Acanthopanacis Trifoliati 15-20 weight portion, Radix seu Caulis Kadsurae Heteroclitae 15-20 weight portion, Radix Anemones Rivularis 3-5 weight portion, Herba Boenninghauseniae Albiflorae 15-20 weight portion, Herba Melastomatis dodecandri 15-20 weight portion, Herba Bulbophylli Odoratissim 15-20 weight portion, Herba Lysimachiae Insignis 15-20 weight portion, Radix et Rhizoma Dispori Cantoniensis 15-20 weight portion, Pterospermi Heterophylli 16-20 weight portion, RADIX DIPLOCCISIAE 15-20 weight portion, Radix Zanthoxyli Spinifolii 10-15 weight portion, Caulis te Folium Callicarpae Longissimae 15-20 weight portion, smelly Camphor tree 10-18 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 5-10 weight portion, Radix Allii Fistulosi 15-22 weight portion, Herba pimpinellae diversifoliae 15-20 weight portion, Herba Colei Pumili 2-4 weight portion, it fluffy daughter root 1-3 weight portion, Herba Ainsliaeae Latifoliae 15-20 weight portion, Herba Pogostemonis 15-20 weight portion, Radix Aconiti Coreani 2-4 weight portion, Radix Veratri Taliensis 1-3 weight portion, Herb Pararuelliae delavayanae 15-20 weight portion, Herba Homalocladii Platycladii 15-20 weight portion, Herba Dicranostigmatis Leptopodi 1-3 weight portion, Herba Spilanthis Acmellae 15-20 weight portion, Cortex Ilicis Rotundae 10-15 weight portion, Folium daphnes odorae 15-20 weight portion, Herba Corallodisci Flabellati 15-20 weight portion, Lindera megaphylla 8-15 weight portion, Herba Syneilesis Aconitifoliae 15-20 weight portion, Herba pronephrii triphylli 8-15 weight portion, Herba Crotalariae Ferrugineae 15-20 weight portion, Semen Hoveniae (Fructus Hoveniae) 12-20 weight portion, Semen Ziziphi Spinosae 15-20 weight portion and white JIUGUNIU 15-20 weight portion.
Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 14 weight portion, Radix Acanthopanacis Trifoliati 15 weight portion, Radix seu Caulis Kadsurae Heteroclitae 18 weight portion, Radix Anemones Rivularis 4 weight portion, Herba Boenninghauseniae Albiflorae 12 weight portion, Herba Melastomatis dodecandri 18 weight portion, Herba Bulbophylli Odoratissim 22 weight portion, Herba Lysimachiae Insignis 15 weight portion, Radix et Rhizoma Dispori Cantoniensis 18 weight portion, Pterospermi Heterophylli 18 weight portion, RADIX DIPLOCCISIAE 12 weight portion, Radix Zanthoxyli Spinifolii 12 weight portion, Caulis te Folium Callicarpae Longissimae 15 weight portion, smelly Camphor tree 12 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6 weight portion, Radix Allii Fistulosi 18 weight portion, Herba pimpinellae diversifoliae 14 weight portion, Herba Colei Pumili 2 weight portion, it fluffy daughter root 2 weight portion, Herba Ainsliaeae Latifoliae 16 weight portion, Herba Pogostemonis 15 weight portion, Radix Aconiti Coreani 2 weight portion, Radix Veratri Taliensis 2 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Herba Homalocladii Platycladii 18 weight portion, Herba Dicranostigmatis Leptopodi 2 weight portion, Herba Spilanthis Acmellae 18 weight portion, Cortex Ilicis Rotundae 14 weight portion, Folium daphnes odorae 18 weight portion, Herba Corallodisci Flabellati 12 weight portion, Lindera megaphylla 12 weight portion, Herba Syneilesis Aconitifoliae 15 weight portion, Herba pronephrii triphylli 12 weight portion, Herba Crotalariae Ferrugineae 15 weight portion, Semen Hoveniae (Fructus Hoveniae) 16 weight portion, Semen Ziziphi Spinosae 15 weight portion and white JIUGUNIU 18 weight portion.
Wherein, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 17 weight portion, Radix Acanthopanacis Trifoliati 18 weight portion, Radix seu Caulis Kadsurae Heteroclitae 18 weight portion, Radix Anemones Rivularis 3 weight portion, Herba Boenninghauseniae Albiflorae 16 weight portion, Herba Melastomatis dodecandri 16 weight portion, Herba Bulbophylli Odoratissim 18 weight portion, Herba Lysimachiae Insignis 18 weight portion, Radix et Rhizoma Dispori Cantoniensis 16 weight portion, Pterospermi Heterophylli 18 weight portion, RADIX DIPLOCCISIAE 16 weight portion, Radix Zanthoxyli Spinifolii 12 weight portion, Caulis te Folium Callicarpae Longissimae 18 weight portion, smelly Camphor tree 15 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6 weight portion, Radix Allii Fistulosi 20 weight portion, Herba pimpinellae diversifoliae 16 weight portion, Herba Colei Pumili 2 weight portion, it fluffy daughter root 2 weight portion, Herba Ainsliaeae Latifoliae 16 weight portion, Herba Pogostemonis 17 weight portion, Radix Aconiti Coreani 2 weight portion, Radix Veratri Taliensis 2 weight portion, Herb Pararuelliae delavayanae 16 weight portion, Herba Homalocladii Platycladii 18 weight portion, Herba Dicranostigmatis Leptopodi 1 weight portion, Herba Spilanthis Acmellae 16 weight portion, Cortex Ilicis Rotundae 12 weight portion, Folium daphnes odorae 16 weight portion, Herba Corallodisci Flabellati 18 weight portion, Lindera megaphylla 12 weight portion, Herba Syneilesis Aconitifoliae 16 weight portion, Herba pronephrii triphylli 12 weight portion, Herba Crotalariae Ferrugineae 16 weight portion, Semen Hoveniae (Fructus Hoveniae) 15 weight portion, Semen Ziziphi Spinosae 18 weight portion and white JIUGUNIU 16 weight portion.
In order to achieve the above object, present invention also offers the preparation method of described medicine, wherein, the dosage form of described medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.05 ~ 0.08Mpa, relative density is the mastic of 1.04 ~ 1.14, spraying dry, the inlet temperature 165 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
Wherein, the dosage form of described medicine is oral solutions, and its preparation method comprises the following steps:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 2 ~ 4 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 2 ~ 5 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 80 ~ 95%, make concentration reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 2 ~ 4 times amount, the sucrose of 0.1 ~ 0.2 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
Wherein, the dosage form of described medicine is syrup, and its preparation method comprises the following steps:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in described ratio, adding relative to the determining alcohol of 2 ~ 5 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.15, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis and Herb Pararuelliae delavayanae are mixed in described ratio, be ground into powder, be that the ethanol of 80% ~ 90% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 50-60 DEG C, relative density is the mastic of 1.22 ~ 1.25, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 3 ~ 5 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives mannitol, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: mannitol 20 ~ 40%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
Wherein, dosage form can also be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.
The invention has the beneficial effects as follows: this Drug therapy infant hip joint hydrops, good effect, determined curative effect, instant effect, patient being reached to the effect of relaxing muscles and tendons to promote blood circulation, expelling wind and cold, reducing swelling and alleviating pain, invigorating the spleen and replenishing QI, by regulating and microcosmic improvement matrix macroscopic view from inside to outside, thus reaching treating both the principal and secondary aspects of a disease, improve the object of the state of an illness, and have no side effect.
Detailed description of the invention
The present invention treats infant hip joint hydrops, this Drug therapy infant hip joint hydrops, good effect, determined curative effect, instant effect, its formula is: Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae, Herba Melastomatis dodecandri, Herba Bulbophylli Odoratissim, Herba Lysimachiae Insignis, Radix et Rhizoma Dispori Cantoniensis, Pterospermi Heterophylli, RADIX DIPLOCCISIAE, Radix Zanthoxyli Spinifolii, Caulis te Folium Callicarpae Longissimae, smelly Camphor tree, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix Allii Fistulosi, Herba pimpinellae diversifoliae, Herba Colei Pumili, it fluffy daughter root, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis, Herb Pararuelliae delavayanae, Herba Homalocladii Platycladii, Herba Dicranostigmatis Leptopodi, Herba Spilanthis Acmellae, Cortex Ilicis Rotundae, Folium daphnes odorae, Herba Corallodisci Flabellati, Lindera megaphylla, Herba Syneilesis Aconitifoliae, Herba pronephrii triphylli, Herba Crotalariae Ferrugineae, Semen Hoveniae (Fructus Hoveniae), Semen Ziziphi Spinosae and white JIUGUNIU.
Wherein, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae, Herba Melastomatis dodecandri, Herba Bulbophylli Odoratissim, Herba Lysimachiae Insignis, Radix et Rhizoma Dispori Cantoniensis, Pterospermi Heterophylli, RADIX DIPLOCCISIAE relaxing muscles and tendons to promote blood circulation; Radix Zanthoxyli Spinifolii, Caulis te Folium Callicarpae Longissimae, smelly Camphor tree, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix Allii Fistulosi, Herba pimpinellae diversifoliae, Herba Colei Pumili, the fluffy daughter root in sky, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani expelling wind and cold; Radix Veratri Taliensis, Herb Pararuelliae delavayanae, Herba Homalocladii Platycladii, Herba Dicranostigmatis Leptopodi, Herba Spilanthis Acmellae, Cortex Ilicis Rotundae, Folium daphnes odorae, Herba Corallodisci Flabellati, Lindera megaphylla, Herba Syneilesis Aconitifoliae, Herba pronephrii triphylli reducing swelling and alleviating pain; Herba Crotalariae Ferrugineae, Semen Hoveniae (Fructus Hoveniae), Semen Ziziphi Spinosae and white JIUGUNIU invigorating the spleen and replenishing QI.Ingredients scientific matching, reaches the effect of relaxing muscles and tendons to promote blood circulation, expelling wind and cold, reducing swelling and alleviating pain, invigorating the spleen and replenishing QI to patient.
Now the pharmacology of every raw medicinal material is described below:
Lycopodium casuarinoides Spring: [nature and flavor] are micro-sweet, temperature.[function cures mainly] relaxing muscles and tendons to promote blood circulation, wind-damp dispelling.For rheumatic arthritis, traumatic injury, menoxenia.
Radix Acanthopanacis Trifoliati: [nature and flavor] toil is cool.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature, bitter in the mouth is pungent." 2. " the SHENGCAO property of medicine is standby to be wanted ": " bitter in the mouth is pungent, cold nature." 3. " vegetation is side just ": " Gan Xin, is slightly cold." [return through] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " enters lung, kidney." 2. " east, Fujian book on Chinese herbal medicine ": " enters liver, kidney, stomach three warp." [function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Cure cold high heat, cough with blood-flecked phlegm, rheumatic arthritis, jaundice, leucorrhea, lithangiuria, traumatic injury, furuncle and phyma skin infection.
Radix seu Caulis Kadsurae Heteroclitae: [nature and flavor] " choosing of Simao, Yunnan Chinese herbal medicine ": " micro-cover with mat pungent, temperature." [function cures mainly] expelling wind and removing dampness, promoting flow of QI and blood.Dispelling the wind and dampness pathogens arthralgia pain, gastric and duodenal ulcers, acute/chronic gastroenteritis, dysmenorrhea, puerperal abdonimal pain, traumatic injury.1. " register planted by Guangxi medicine ": " stem: bring down a fever, quenches the thirst.Control cough, liver lung-heat." 2. " Guangxi Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Wind-damp dispelling.Control traumatic injury, rheumatic ostalgia, dysmenorrhea, puerperal abdonimal pain. acute/chronic gastroenteritis." 3. " the practical Chinese herbal medicine in Guangxi newly selects ": " dispels the wind, analgesia, relaxing muscles and tendons to promote blood circulation." 4. " choosing of Yunnan Chinese herbal medicine "): " rattan: treat for stomachache, gastric and duodenal ulcers."
Radix Anemones Rivularis: [nature and flavor] are pungent, bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, tonsillitis, toothache, stomachache, acute hepatitis, chronic hepatitis, rheumatalgia, traumatic injury.
Herba Boenninghauseniae Albiflorae: [nature and flavor] " choosing of Yunnan Chinese herbal medicine ": " pungent light, cold.Belly pain is controlled in " [function cures mainly] be " will planted by middle traditional Chinese medicines " 1.: " decoction.Leaf is mashed external application and is controlled scald." 2. " choosing of Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, relaxing muscles and tendons to promote blood circulation, antiinflammatory.Cure cold, pharyngolaryngitis, hepatitis, spitting of blood, epistaxis, lumbago, traumatic injury, ecchymoma."
Herba Melastomatis dodecandri: [nature and flavor] " east, Fujian book on Chinese herbal medicine ": " property is put down, the micro-sweet acid of taste." [return through] " east, Fujian book on Chinese herbal medicine ": " enters liver, kidney, spleen, lung four warp." [function cures mainly] invigorates blood circulation, hemostasis, dampness removing, removing toxic substances.Control dysmenorrhea, puerperal abdonimal pain, metrorrhagia, leucorrhea, dysentery, scrofula, toothache.1. " Zhiwu Mingshi Tukao ": " control strain." 2. " south of the Five Ridges gather medicinal herbs record ": " controls puerperal abdonimal pain, dysentery with red and white feces." 3. " east, Fujian book on Chinese herbal medicine ": " can stop blooding and invigorate blood circulation, the hernia that disappears of detoxifying.Control dysmenorrhea, metrorrhagia and leukorrhagia, dysentery, hemorrhoid complicated by anal fistula, rubella, hernia." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " relieving dysentery with astringents, relaxing muscles and tendons and activating QI and blood in the collateral, enriching blood to prevent miscarriage.Control enteritis, bacillary dysentery; Lumbago and skelalgia, rheumatic ostalgia; Pregnant woman anemia, frequent fetal movement, menorrhagia." 5. " Fujian Chinese herbal medicine ": " invigorating the spleen and replenishing QI."
Herba Bulbophylli Odoratissim: [nature and flavor] are sweet, light is flat.[function cures mainly] moistening the lung and resolving phlegm, relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory.For hemoptysis of pulmonary tuberculosis, chronic tracheitis, chronic pharyngitis, rheumatism bones and muscles pain; Fracture is controlled in external, and traumatic injury is dampened, knife injury.
Herba Lysimachiae Insignis: [nature and flavor] " Yunnan Chinese herbal medicine ": " arduous, temperature." [function cures mainly] be " Yunnan Chinese herbal medicine " 1.: " dispelling wind dredging collateral, suppressing the hyperactive liver." 2. " mountain of papers Chinese herbal medicine ": " expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation."
Radix et Rhizoma Dispori Cantoniensis: [nature and flavor] sweet, micro-hardship is flat.[function cures mainly] tonifying the lung kidney, antitussive, stomach invigorating is stopped blooding.Cure mainly deficiency of vital energy dizziness, tinnitus void is coughed, after being ill inappetence, spits blood.
Pterospermi Heterophylli: [nature and flavor] are sweet, temperature.[function cures mainly] expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.
RADIX DIPLOCCISIAE: [nature and flavor] micro-hardship, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.For rheumatic ostalgia, cholecystitis, urinary tract infection, venom.
Radix Zanthoxyli Spinifolii: [nature and flavor] are pungent, temperature.1. " Guizhou medical herbs ": " pungent, temperature." 2. " Shaanxi Chinese herbal medicine ": " is puckery pungent, flat." [function cures mainly] expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesia.Control cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation.1. " Guizhou medical herbs ": " wind dispelling, cold expelling." 2. " Shaanxi Chinese herbal medicine ": " relaxing muscles and tendons to promote blood circulation, hemostasis, detumescence, analgesia.Control traumatic injury, traumatic hemorrhage, swelling and pain due to blood stasis."
Caulis te Folium Callicarpae Longissimae: [nature and flavor] are pungent, temperature.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." 2. " Fujian Chinese herbal medicine ": " toil, temperature." [function cures mainly] expelling wind and cold, sterilization of invigorating blood circulation.Dispelling the wind and dampness pathogens osteodynia, cough due to wind and cold, abdominal pain due to accumulation of cold, innominate toxic swelling, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook ": " promoting flow of QI and blood, detumescence of dispeling the wind.Control traumatic injury, fracture, rheumatic lumbago and scelalgia, venom."
Smelly Camphor tree: [nature and flavor] are pungent, temperature.[function cures mainly] expelling wind and cold, regulating QI to relieve pain.For flu, heatstroke, bronchitis, dyspepsia flatulence, stomachache, diarrhoea distending pain, rheumatic arthritis.
Radix Piperis sarmentosi (Herba Piperis Sarmentosi): [function cures mainly] treating malaria disease, beriberi, toothache, hemorrhoid.1. " the SHENGCAO property of medicine is standby to be wanted ": " control toothache, wash rotten foot." 2. " book on Chinese herbal medicine asks former ": " washes hemorrhoid." 3. " south of the Five Ridges gather medicinal herbs record ": " and ovum gallinaceum cook it, can treat malaria.All trouble spouting bleeding from anus skin ulcers, smash deposited it.Reason beriberi disease, decocting takes washout orally." 4. " wild medicine is planted figure and said ": " decocts water washing ulcer, malignant boil."
Radix Allii Fistulosi: [nature and flavor] hide pungent; Property is put down.[return through] lung meridian.[function cures mainly] expelling wind and cold; Removing toxic substances; Dissipating blood stasis.Main headche due to wind-cold; Abscess of the throat; Hemorrhoid; Cold injury.
Herba pimpinellae diversifoliae: [nature and flavor] pungent, micro-hardship, temperature.[function cures mainly] expelling wind and activating blood circulation, removing toxic substances and promoting subsidence of swelling.For flu, laryngopharynx swelling and pain, dysentery, icterohepatitis; Venom is controlled in external, traumatic injury, skin itching.
Herba Colei Pumili: [nature and flavor] pungent, micro-hardship, temperature.[function cures mainly] dispelling cold by warming the meridian, expelling phlegm for arresting cough, dissipating blood stasis for subsidence of swelling.For cough due to wind and cold, chronic bronchitis, asthma, chronic gastritis, wind and cold arthralgia pain; Traumatic injury is controlled in external, venom.
It fluffy daughter root: [nature and flavor] are pungent, bitter, temperature.[function cures mainly] expelling wind and cold, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving.For traumatic injury, arthralgia, paralysis, tetanus.
Herba Ainsliaeae Latifoliae: [nature and flavor] are pungent, bitter, temperature.[function cures mainly] expelling wind and cold, cough-relieving, dysentery relieving.Control the diseases such as cough due to wind and cold, enteritis, dysentery.
Herba Pogostemonis: [nature and flavor] acrid in the mouth; Bitter; Warm in nature.[function cures mainly] expelling wind and cold; Warming middle-JIAO is regulated the flow of vital energy.Main anemofrigid cold; Cough with asthma is out of breath; Abdominal distention; Dyspepsia; Dysentery is suffered from abdominal pain; The whole body is numb; Traumatic injury.
Radix Aconiti Coreani: [nature and flavor] are pungent, sweet, greatly temperature.[function cures mainly] dispels the wind expectorant, by cold-damp.For migraine and general headache, arthralgia due to cold-dampnes, facial hemiparalysis.
Radix Veratri Taliensis: [nature and flavor] " Yunnan Chinese herbal medicine ": " fiber crops are bitter, cool." [function cures mainly] dissipating blood stasis for subsidence of swelling, pain easing and hemostasis, eliminates the phlegm, and has one's ideas straightened out.Control traumatic injury, fracture, paraplegia, epilepsy, rheumatalgia, wound hemorrhage.1. " Yunnan Chinese herbal medicine ": " reducing swelling and alleviating pain.Control traumatic injury, rheumatalgia." 2. " choosing of Yunnan Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, anti-inflammatory analgetic, synthetism, hemostasis.Control traumatic injury, fracture, traumatic hemorrhage, paraplegia, epilepsy." 3. " catalogue planted by Guizhou medicine ": " eliminates the phlegm emetic, heat clearing away wind dispelling.Control mad disease, cold stuffy nasal obstruction, metrorrhagia."
Herb Pararuelliae delavayanae: [nature and flavor] " Yunnan Chinese herbal medicine ": " sweet light, flat." [function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control pneumonia, tonsillitis, parotitis, scrofula, abscess sore, fracture, traumatic infection.1. " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control fracture, tuberculous lymphadenitis, parotitis, traumatic hemorrhage." 2. " choosing of Yunnan Chinese herbal medicine ": " antiinflammatory is drawn out pus by applying a plaster to the affected part, granulation promoting, dissipating blood stasis tissue regeneration promoting, parasite killing.Control acute suppurative tonsillitis, pneumonia, sore abscess, the raw maggot of wound infection." 3. " catalogue planted by Guizhou medicine ": " controls impairment caused by overstrain, delivers."
Herba Homalocladii Platycladii: [nature and flavor] are sweet, light is flat.[function cures mainly] promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.Cure mainly carbuncle pyogenic infections from tumour or sore, traumatic injury, poisonous snake and centipete bite.
Herba Dicranostigmatis Leptopodi: [nature and flavor] are bitter, puckery, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain, parasite killing.For tonsillitis, toothache, tuberculous lymphadenitis; Tinea capitis is controlled in external, tinea corporis.
Herba Spilanthis Acmellae: [nature and flavor] are pungent, temperature.[function cures mainly] detoxification and promoting urination, relieving cough and relieving asthma, reducing swelling and alleviating pain.For malaria, toothache, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis.Venom is controlled in external, dog bite, carbuncle furuncle and phyma poison.
Cortex Ilicis Rotundae: [nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flu, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, rheumatic ostalgia; Traumatic injury is controlled in external, carbuncle furuncle infections, traumatic hemorrhage, burn and scald.
Folium daphnes odorae: [nature and flavor] acrid in the mouth; Property is put down.[return through] lung; Spleen channel.[function cures mainly] detoxifies; Reducing swelling and alleviating pain.Main skin infection; Acute mastitis; Gout.
Herba Corallodisci Flabellati: [nature and flavor] bitter in the mouth; Pungent; Cold in nature.[return through] Liver Channel.[function cures mainly] clearing away damp-heat; Separate sore; Promoting blood circulation and stopping pain.Main damp and hot arthralgia pain; Sore swollen toxin; Laryngopharynx swelling and pain; Leucorrhea with red and white discharge; Traumatic injury; Traumatic hemorrhage.
Lindera megaphylla: [nature and flavor] pungent, micro-hardship, temperature.[function cures mainly] expelling wind and removing dampness, reducing swelling and alleviating pain.
Herba Syneilesis Aconitifoliae: [nature and flavor] are pungent, tepor.[function cures mainly] wind-damp dispelling, relaxing muscles and tendons to promote blood circulation, pain relieving.For lumbago and skelalgia, traumatic injury.
Herba pronephrii triphylli: [nature and flavor] toil is flat.1. " Guangdong Chinese medicine " II: " micro-puckery, flat." 2. " Guangdong Chinese herbal medicine ": " micro-toil, flat." [function cures mainly] detoxifies, detumescence, antipruritic.Control sore and toxic, traumatic injury, edema, eczema, skin pruritus.1. " Guangdong Chinese medicine " II: " removing toxic substances, antiinflammatory, reducing swelling and alleviating pain.Control carbuncle sore tumefacting virus, furuncle.Skin pruritus, regurgitation, edema." 2. " Guangdong Chinese herbal medicine ": " loose poison, detumescence, pain relieving.Control venom, traumatic injury, eczema, dermatitis, carbuncle furuncle swells."
Herba Crotalariae Ferrugineae: [nature and flavor] bitter micro-acid, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, the micro-acid of bitter in the mouth." 2. " this sketch of the southern regions of the Yunnan Province is said ": " sad hardship of abnormal smells from the patient." [return through] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters lung." [function cures mainly] astringes the lung gas, spleen reinforcing kidney, diuresis, detumescence poison.Control chronic cough expectorant blood, tinnitus, deaf, nocturnal emission, chronic nephritis, cystitis, renal calculus, tonsillitis, lymphadenitis, furunculosis, malignant boil.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " gas of astringing the lung, cough-relieving, expectorant, Dingchuan." 2. " this sketch of the southern regions of the Yunnan Province is said ": " controls knot in stranguria caused by urinary stone; Mash deposited skin ulcer." 3. " vegetation is side just ": " invigorating the spleen and replenishing QI, treat tinnitus, the head is giddy, collapses pouring.Pathogenic fire purging heat clearing away again, suppressing liver-wind, detumescence pain."
Semen Hoveniae (Fructus Hoveniae): [nature and flavor] sweet acid is flat.1. Tang Materia Medica: " sweet in the mouth is flat, nontoxic.The acid of " 2. " book on Chinese herbal medicine is new again ": " sweet in the mouth, property is put down, nontoxic." [returning through] 1. " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." 2. " book on Chinese herbal medicine brief points ": " enters meridian of Hand-TAI YIN." [function cures mainly] is controlled drunk, and dysphoria with smothery sensation is thirsty, vomiting, difficulty in urination and defecation.1. " Jingchusuishiji ": " ward off insect poison." 2. Tang Materia Medica: " main wind syndrome of head, lower abdomen contracture." 3. supplement to the Herbal: " relieving restlessness of quenching the thirst, moistening five ZANG-organs, sharp defecation, go heat on diaphragm, function is as honey." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls the right paralysis of all left paralysiss, rheumatic numbness, energy alcoholic intoxication; Or steep in wine and take it, also can relaxing muscles and tendons network.Children's takes it, changes worm, supports spleen." 5. " this sketch of the southern regions of the Yunnan Province is said ": " invigorating the spleen and replenishing QI.Phlegm-fire closes to be tied in the heart, can separate with this.' 6. " detailed outline ": " preventing or arresting vomiting is inverse."
Semen Ziziphi Spinosae: [nature and flavor] are sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." [return through] enters the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." [function cures mainly] nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.1. " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." 2. " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong."
White JIUGUNIU: [nature and flavor] are pungent, micro-sweet, flat.[function cures mainly] eliminating the toxic material out by tonification, invigorating the spleen and replenishing QI.For lymphadenitis, furuncle, carbuncle, chronic suppurative osteomyelisis, the deficiency of vital energy is dizzy, tinnitus.
Preferably, described medicine is only made up of above-mentioned raw materials medicine.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
Formula: Lycopodium casuarinoides Spring 15g, Radix Acanthopanacis Trifoliati 18g, Radix seu Caulis Kadsurae Heteroclitae 15g, Radix Anemones Rivularis 3g, Herba Boenninghauseniae Albiflorae 16g, Herba Melastomatis dodecandri 17g, Herba Bulbophylli Odoratissim 18g, Herba Lysimachiae Insignis 14g, Radix et Rhizoma Dispori Cantoniensis 20g, Pterospermi Heterophylli 20g, RADIX DIPLOCCISIAE 15g, Radix Zanthoxyli Spinifolii 12g, Caulis te Folium Callicarpae Longissimae 15g, smelly Camphor tree 15g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 8g, Radix Allii Fistulosi 18g, Herba pimpinellae diversifoliae 15g, Herba Colei Pumili 2g, it fluffy daughter root 2g, Herba Ainsliaeae Latifoliae 16g, Herba Pogostemonis 18g, Radix Aconiti Coreani 2g, Radix Veratri Taliensis 2g, Herb Pararuelliae delavayanae 15g, Herba Homalocladii Platycladii 18g, Herba Dicranostigmatis Leptopodi 2g, Herba Spilanthis Acmellae 18g, Cortex Ilicis Rotundae 14g, Folium daphnes odorae 18g, Herba Corallodisci Flabellati 15g, Lindera megaphylla 12g, Herba Syneilesis Aconitifoliae 12g, Herba pronephrii triphylli 10g, Herba Crotalariae Ferrugineae 15g, Semen Hoveniae (Fructus Hoveniae) 18g, Semen Ziziphi Spinosae 15g and white JIUGUNIU 18g,
Its preparation method is:
Step one: raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 85%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.06Mpa, relative density is the mastic of 1.08, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.1 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2 oral solutions
Formula: Lycopodium casuarinoides Spring 14g, Radix Acanthopanacis Trifoliati 15g, Radix seu Caulis Kadsurae Heteroclitae 18g, Radix Anemones Rivularis 4g, Herba Boenninghauseniae Albiflorae 12g, Herba Melastomatis dodecandri 18g, Herba Bulbophylli Odoratissim 22g, Herba Lysimachiae Insignis 15g, Radix et Rhizoma Dispori Cantoniensis 18g, Pterospermi Heterophylli 18g, RADIX DIPLOCCISIAE 12g, Radix Zanthoxyli Spinifolii 12g, Caulis te Folium Callicarpae Longissimae 15g, smelly Camphor tree 12g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6g, Radix Allii Fistulosi 18g, Herba pimpinellae diversifoliae 14g, Herba Colei Pumili 2g, it fluffy daughter root 2g, Herba Ainsliaeae Latifoliae 16g, Herba Pogostemonis 15g, Radix Aconiti Coreani 2g, Radix Veratri Taliensis 2g, Herb Pararuelliae delavayanae 15g, Herba Homalocladii Platycladii 18g, Herba Dicranostigmatis Leptopodi 2g, Herba Spilanthis Acmellae 18g, Cortex Ilicis Rotundae 14g, Folium daphnes odorae 18g, Herba Corallodisci Flabellati 12g, Lindera megaphylla 12g, Herba Syneilesis Aconitifoliae 15g, Herba pronephrii triphylli 12g, Herba Crotalariae Ferrugineae 15g, Semen Hoveniae (Fructus Hoveniae) 16g, Semen Ziziphi Spinosae 15g and white JIUGUNIU 18g,
Its preparation method is:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in proportion, be that the methanol of 75% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 3 times obtained relative to second step, decocts 3 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 2 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 85%, make concentration reach 75%, leave standstill 12 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 3 times amount, the sucrose of 0.1 times, the sodium benzoate of 0.01 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
Embodiment 3 syrup
Formula: Lycopodium casuarinoides Spring 17g, Radix Acanthopanacis Trifoliati 18g, Radix seu Caulis Kadsurae Heteroclitae 18g, Radix Anemones Rivularis 3g, Herba Boenninghauseniae Albiflorae 16g, Herba Melastomatis dodecandri 16g, Herba Bulbophylli Odoratissim 18g, Herba Lysimachiae Insignis 18g, Radix et Rhizoma Dispori Cantoniensis 16g, Pterospermi Heterophylli 18g, RADIX DIPLOCCISIAE 16g, Radix Zanthoxyli Spinifolii 12g, Caulis te Folium Callicarpae Longissimae 18g, smelly Camphor tree 15g, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6g, Radix Allii Fistulosi 20g, Herba pimpinellae diversifoliae 16g, Herba Colei Pumili 2g, it fluffy daughter root 2g, Herba Ainsliaeae Latifoliae 16g, Herba Pogostemonis 17g, Radix Aconiti Coreani 2g, Radix Veratri Taliensis 2g, Herb Pararuelliae delavayanae 16g, Herba Homalocladii Platycladii 18g, Herba Dicranostigmatis Leptopodi 1g, Herba Spilanthis Acmellae 16g, Cortex Ilicis Rotundae 12g, Folium daphnes odorae 16g, Herba Corallodisci Flabellati 18g, Lindera megaphylla 12g, Herba Syneilesis Aconitifoliae 16g, Herba pronephrii triphylli 12g, Herba Crotalariae Ferrugineae 16g, Semen Hoveniae (Fructus Hoveniae) 15g, Semen Ziziphi Spinosae 18g and white JIUGUNIU 16g,
Its preparation method is:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 85%, heating and refluxing extraction 3 times, each reflux, extract, 2 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05, by dry with spray dryer for the concentrated solution after concentrated, be ground into 150 orders subsequently, obtain dry powder;
Second step, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis and Herb Pararuelliae delavayanae being mixed in described ratio, be ground into powder, is that the ethanol of 85% is as solvent with determining alcohol, flood 48 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 55 DEG C, relative density is the mastic of 1.22, dry with spray dryer, be ground into 150 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;
3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 times amount determining alcohol be 75% alcohol reflux 3 times, each 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20, in 55 DEG C of reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives mannitol, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: mannitol 30%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.2% or paraben preservative are as ethyl hydroxybenzoate 0.02%.
The toxicity test of medicine
1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 40 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>40 crude drug/kg of the present invention, every day, maximum dosage-feeding was 80 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 5g crude drug/day/people, weight in patients is in 30KG, and average dosage is 0.167g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 240 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.
2. cumulative toxicity test: select 20 healthy mices, female, each 10 of hero, with the syrup of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that medicine of the present invention does not have cumulative toxicity.
Clinical trial
Data and method
In May, 2014 ~ in December, 2014 is good for side and Ipsilateral hip joint carries out monitoring record at the 400 routine infants because of the one-sided hip arthralgia, limitation of activity, limping, be all infant hip joint hydrops card, about 2 ~ 12 years old its age, 6 years old mean age, boy 119 example, girl 81 example.Clinical symptoms has shiver with cold, high heat, sharp ache etc.Wherein 200 routine patients will be divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.
Therapeutic Method
Embodiment 1 group: this organizes the granule that 50 people use embodiments of the invention 1, every day 2 times, each 5g 7 days is a course for the treatment of, treats 2 courses for the treatment of.
Embodiment 2 groups: this organizes the oral solutions that 50 people take embodiments of the invention 2, every day 2 times, each oral 20ml.Within 7 days, be a course for the treatment of, treat 2 courses for the treatment of.
Embodiment 3 groups: this is organized 50 people and uses the syrup of embodiments of the invention 3 to treat.Every day 2 times, each oral 10ml, i.e. 5g.Within 7 days, be a course for the treatment of, treat 2 courses for the treatment of.
Matched group: this organizes the oral synovitis sheet of 50 people, one time 1,3 times on the one.Within 7 days, be a course for the treatment of, treat 2 courses for the treatment of.
Criterion of therapeutical effect
Effective: hydrops disappears, symptom is eliminated; Take a turn for the better: hydrops disappears substantially, and symptom is eliminated substantially; Invalid: to have no improvement.
Therapeutic outcome
Table 1 is the therapeutic effect contrast of each group
| Group | Effective | Take a turn for the better | Invalid |
| Embodiment 1 group | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 2 groups | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 3 groups | 50（100%） | 0（0%） | 0（0%） |
| Matched group | 20（40%） | 10（20%） | 20（40%） |
As can be seen from Table 1, the therapeutic effect of three treatment groups is obviously all better than matched group, it can thus be appreciated that medicine of the present invention, and treatment infant hip joint hydrops, good effect.
Table 2 is the recurrence contrast of three embodiment groups
| Group | There is number in side effect | Side effect occurrence rate |
| Embodiment 1 group | 0 | 0 |
| Embodiment 2 groups | 0 | 0 |
| Embodiment 3 groups | 0 | 0 |
As can be seen from Table 2, there is not recurrence in the patient of three treatment groups over the course for the treatment of, it can thus be appreciated that medicine of the present invention, treatment infant hip joint hydrops, without recurrence.
In sum, medicine of the present invention, treatment infant hip joint hydrops, good effect, instant effect, has no side effect, and does not recur.
Typical case: children's hospital of province receives a patient, female, 5 years old, is diagnosed as infant hip joint hydrops, and use the granule of embodiments of the invention 1, every day 2 times, each 5g 7 days is a course for the treatment of, treats 2 courses for the treatment of, and hydrops disappears, transference cure.Again do not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. treat the medicine of infant hip joint hydrops for one kind, it is characterized in that, described medicine is obtained by following raw medicinal material: Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae, Herba Melastomatis dodecandri, Herba Bulbophylli Odoratissim, Herba Lysimachiae Insignis, Radix et Rhizoma Dispori Cantoniensis, Pterospermi Heterophylli, RADIX DIPLOCCISIAE, Radix Zanthoxyli Spinifolii, Caulis te Folium Callicarpae Longissimae, smelly Camphor tree, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Radix Allii Fistulosi, Herba pimpinellae diversifoliae, Herba Colei Pumili, it fluffy daughter root, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis, Herb Pararuelliae delavayanae, Herba Homalocladii Platycladii, Herba Dicranostigmatis Leptopodi, Herba Spilanthis Acmellae, Cortex Ilicis Rotundae, Folium daphnes odorae, Herba Corallodisci Flabellati, Lindera megaphylla, Herba Syneilesis Aconitifoliae, Herba pronephrii triphylli, Herba Crotalariae Ferrugineae, Semen Hoveniae (Fructus Hoveniae), Semen Ziziphi Spinosae and white JIUGUNIU.
2. medicine according to claim 1, is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 10-25 weight portion, Radix Acanthopanacis Trifoliati 13-24 weight portion, Radix seu Caulis Kadsurae Heteroclitae 12-20 weight portion, Radix Anemones Rivularis 3-5 weight portion, Herba Boenninghauseniae Albiflorae 10-20 weight portion, Herba Melastomatis dodecandri 15-20 weight portion, Herba Bulbophylli Odoratissim 15-23 weight portion, Herba Lysimachiae Insignis 10-20 weight portion, Radix et Rhizoma Dispori Cantoniensis 15-24 weight portion, Pterospermi Heterophylli 16-25 weight portion, RADIX DIPLOCCISIAE 10-20 weight portion, Radix Zanthoxyli Spinifolii 8-15 weight portion, Caulis te Folium Callicarpae Longissimae 12-20 weight portion, smelly Camphor tree 10-18 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 5-10 weight portion, Radix Allii Fistulosi 15-22 weight portion, Herba pimpinellae diversifoliae 10-20 weight portion, Herba Colei Pumili 2-4 weight portion, it fluffy daughter root 1-3 weight portion, Herba Ainsliaeae Latifoliae 15-20 weight portion, Herba Pogostemonis 10-20 weight portion, Radix Aconiti Coreani 2-4 weight portion, Radix Veratri Taliensis 1-3 weight portion, Herb Pararuelliae delavayanae 10-20 weight portion, Herba Homalocladii Platycladii 15-20 weight portion, Herba Dicranostigmatis Leptopodi 1-3 weight portion, Herba Spilanthis Acmellae 15-25 weight portion, Cortex Ilicis Rotundae 10-20 weight portion, Folium daphnes odorae 15-25 weight portion, Herba Corallodisci Flabellati 10-20 weight portion, Lindera megaphylla 8-15 weight portion, Herba Syneilesis Aconitifoliae 10-20 weight portion, Herba pronephrii triphylli 8-15 weight portion, Herba Crotalariae Ferrugineae 10-20 weight portion, Semen Hoveniae (Fructus Hoveniae) 12-25 weight portion, Semen Ziziphi Spinosae 10-20 weight portion and white JIUGUNIU 15-20 weight portion.
3. medicine according to claim 1 and 2, is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 10-20 weight portion, Radix Acanthopanacis Trifoliati 15-20 weight portion, Radix seu Caulis Kadsurae Heteroclitae 15-20 weight portion, Radix Anemones Rivularis 3-5 weight portion, Herba Boenninghauseniae Albiflorae 15-20 weight portion, Herba Melastomatis dodecandri 15-20 weight portion, Herba Bulbophylli Odoratissim 15-20 weight portion, Herba Lysimachiae Insignis 15-20 weight portion, Radix et Rhizoma Dispori Cantoniensis 15-20 weight portion, Pterospermi Heterophylli 16-20 weight portion, RADIX DIPLOCCISIAE 15-20 weight portion, Radix Zanthoxyli Spinifolii 10-15 weight portion, Caulis te Folium Callicarpae Longissimae 15-20 weight portion, smelly Camphor tree 10-18 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 5-10 weight portion, Radix Allii Fistulosi 15-22 weight portion, Herba pimpinellae diversifoliae 15-20 weight portion, Herba Colei Pumili 2-4 weight portion, it fluffy daughter root 1-3 weight portion, Herba Ainsliaeae Latifoliae 15-20 weight portion, Herba Pogostemonis 15-20 weight portion, Radix Aconiti Coreani 2-4 weight portion, Radix Veratri Taliensis 1-3 weight portion, Herb Pararuelliae delavayanae 15-20 weight portion, Herba Homalocladii Platycladii 15-20 weight portion, Herba Dicranostigmatis Leptopodi 1-3 weight portion, Herba Spilanthis Acmellae 15-20 weight portion, Cortex Ilicis Rotundae 10-15 weight portion, Folium daphnes odorae 15-20 weight portion, Herba Corallodisci Flabellati 15-20 weight portion, Lindera megaphylla 8-15 weight portion, Herba Syneilesis Aconitifoliae 15-20 weight portion, Herba pronephrii triphylli 8-15 weight portion, Herba Crotalariae Ferrugineae 15-20 weight portion, Semen Hoveniae (Fructus Hoveniae) 12-20 weight portion, Semen Ziziphi Spinosae 15-20 weight portion and white JIUGUNIU 15-20 weight portion.
4. medicine according to claim 1 and 2, is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 14 weight portion, Radix Acanthopanacis Trifoliati 15 weight portion, Radix seu Caulis Kadsurae Heteroclitae 18 weight portion, Radix Anemones Rivularis 4 weight portion, Herba Boenninghauseniae Albiflorae 12 weight portion, Herba Melastomatis dodecandri 18 weight portion, Herba Bulbophylli Odoratissim 22 weight portion, Herba Lysimachiae Insignis 15 weight portion, Radix et Rhizoma Dispori Cantoniensis 18 weight portion, Pterospermi Heterophylli 18 weight portion, RADIX DIPLOCCISIAE 12 weight portion, Radix Zanthoxyli Spinifolii 12 weight portion, Caulis te Folium Callicarpae Longissimae 15 weight portion, smelly Camphor tree 12 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6 weight portion, Radix Allii Fistulosi 18 weight portion, Herba pimpinellae diversifoliae 14 weight portion, Herba Colei Pumili 2 weight portion, it fluffy daughter root 2 weight portion, Herba Ainsliaeae Latifoliae 16 weight portion, Herba Pogostemonis 15 weight portion, Radix Aconiti Coreani 2 weight portion, Radix Veratri Taliensis 2 weight portion, Herb Pararuelliae delavayanae 15 weight portion, Herba Homalocladii Platycladii 18 weight portion, Herba Dicranostigmatis Leptopodi 2 weight portion, Herba Spilanthis Acmellae 18 weight portion, Cortex Ilicis Rotundae 14 weight portion, Folium daphnes odorae 18 weight portion, Herba Corallodisci Flabellati 12 weight portion, Lindera megaphylla 12 weight portion, Herba Syneilesis Aconitifoliae 15 weight portion, Herba pronephrii triphylli 12 weight portion, Herba Crotalariae Ferrugineae 15 weight portion, Semen Hoveniae (Fructus Hoveniae) 16 weight portion, Semen Ziziphi Spinosae 15 weight portion and white JIUGUNIU 18 weight portion.
5. the medicine according to claim 1 or 3, is characterized in that, described medicine is obtained by the raw medicinal material of following parts by weight: Lycopodium casuarinoides Spring 17 weight portion, Radix Acanthopanacis Trifoliati 18 weight portion, Radix seu Caulis Kadsurae Heteroclitae 18 weight portion, Radix Anemones Rivularis 3 weight portion, Herba Boenninghauseniae Albiflorae 16 weight portion, Herba Melastomatis dodecandri 16 weight portion, Herba Bulbophylli Odoratissim 18 weight portion, Herba Lysimachiae Insignis 18 weight portion, Radix et Rhizoma Dispori Cantoniensis 16 weight portion, Pterospermi Heterophylli 18 weight portion, RADIX DIPLOCCISIAE 16 weight portion, Radix Zanthoxyli Spinifolii 12 weight portion, Caulis te Folium Callicarpae Longissimae 18 weight portion, smelly Camphor tree 15 weight portion, Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 6 weight portion, Radix Allii Fistulosi 20 weight portion, Herba pimpinellae diversifoliae 16 weight portion, Herba Colei Pumili 2 weight portion, it fluffy daughter root 2 weight portion, Herba Ainsliaeae Latifoliae 16 weight portion, Herba Pogostemonis 17 weight portion, Radix Aconiti Coreani 2 weight portion, Radix Veratri Taliensis 2 weight portion, Herb Pararuelliae delavayanae 16 weight portion, Herba Homalocladii Platycladii 18 weight portion, Herba Dicranostigmatis Leptopodi 1 weight portion, Herba Spilanthis Acmellae 16 weight portion, Cortex Ilicis Rotundae 12 weight portion, Folium daphnes odorae 16 weight portion, Herba Corallodisci Flabellati 18 weight portion, Lindera megaphylla 12 weight portion, Herba Syneilesis Aconitifoliae 16 weight portion, Herba pronephrii triphylli 12 weight portion, Herba Crotalariae Ferrugineae 16 weight portion, Semen Hoveniae (Fructus Hoveniae) 15 weight portion, Semen Ziziphi Spinosae 18 weight portion and white JIUGUNIU 16 weight portion.
6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.05 ~ 0.08Mpa, relative density is the mastic of 1.04 ~ 1.14, spraying dry, the inlet temperature 165 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is oral solutions, and its preparation method comprises the following steps:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 2 ~ 4 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 2 ~ 5 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 80 ~ 95%, make concentration reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 2 ~ 4 times amount, the sucrose of 0.1 ~ 0.2 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is syrup, and its preparation method comprises the following steps:
The first step, Lycopodium casuarinoides Spring, Radix Acanthopanacis Trifoliati, Radix seu Caulis Kadsurae Heteroclitae, Radix Anemones Rivularis, Herba Boenninghauseniae Albiflorae and Herba Melastomatis dodecandri are mixed in described ratio, adding relative to the determining alcohol of 2 ~ 5 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.15, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba Ainsliaeae Latifoliae, Herba Pogostemonis, Radix Aconiti Coreani, Radix Veratri Taliensis and Herb Pararuelliae delavayanae are mixed in described ratio, be ground into powder, be that the ethanol of 80% ~ 90% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 50-60 DEG C, relative density is the mastic of 1.22 ~ 1.25, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 3 ~ 5 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, adds the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, adds correctives mannitol, antiseptic mix homogeneously subsequently, obtains syrup; The correctives added, antiseptic and the content in medicine thereof: mannitol 20 ~ 40%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770332A (en) * | 2016-03-10 | 2016-07-20 | 王斌 | Composition for treating developmental dislocation of hip joint and preparation method |
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| CN103520654A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition |
| CN103705751A (en) * | 2014-01-15 | 2014-04-09 | 钱玮 | Traditional Chinese medicine composition for treating rheumatic lumbago and preparation method thereof |
| CN104857224A (en) * | 2015-05-27 | 2015-08-26 | 刘杨 | Traditional Chinese medicine preparation for curing wind cold wetness type transient synovitis and nursing method |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520654A (en) * | 2013-10-25 | 2014-01-22 | 梁轶聪 | Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition |
| CN103705751A (en) * | 2014-01-15 | 2014-04-09 | 钱玮 | Traditional Chinese medicine composition for treating rheumatic lumbago and preparation method thereof |
| CN104857224A (en) * | 2015-05-27 | 2015-08-26 | 刘杨 | Traditional Chinese medicine preparation for curing wind cold wetness type transient synovitis and nursing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105770332A (en) * | 2016-03-10 | 2016-07-20 | 王斌 | Composition for treating developmental dislocation of hip joint and preparation method |
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