CN101181393A - Chinese medicine preparation for curing common cold and producing method thereof - Google Patents
Chinese medicine preparation for curing common cold and producing method thereof Download PDFInfo
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Abstract
The invention provides a Chinese traditional medical preparation for curing fever, headache and cough caused by cold and a production method thereof. The preparation is made of Chinese traditional medicines such as Mussaenda philippica, ivy tree bark skin, platycodon root, sweet wormwood herb, narrowleaf screwtree root and liquoric root and so on with scientific preparation by combining the Chinese traditional medicine theory with the modern mechanical theory. The production method is that the medical materials are processed through the modern medicine making technology such as extraction with water, settlement with alcohol and concentration, and then powder milling and so on to be made into gain preparation, troche and capsule preparation, etc. The medicine has the functions of clearing away heat and toxic material and dispelling wind and relieving cough. The medicine is used for curing the fever, the headache and the cough caused by the cold.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and production method thereof for the treatment of flu.
Background technology
Flu is the common exogenous diseases that causes because of ailment said due to cold or exposure invasion and attack human body.The record of relevant flu sees " interior warp " the earliest, " element is asked the bone empty talk " " wind from outside go into, make us cold with shivering, sweating headache, heavy sensation of the body aversion to cold ".Having illustrated that flu is mainly due to the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, this says with " element asks lunar sun bright opinion ": the viewpoint of " hinder in the wind person, on be subjected to it earlier " is consistent.Later Han Dynasty's Zhang Zhongjing is " Treatise on Febrile Diseases.Distinguish sun abnormal pulse card and control " in the diseases caused by exogenous pathogenic factor exterior syndrome is divided into exterior deficiency syndrome, exterior excess syndrome, for theoretical basis has been established in the dialectical treatment of flu.Sui Dynasty " disorder of QI duke or princess under an emperor during the General Treatise on the Cause and Symptoms of Diseases " has been done deep argumentation to the cause of disease and the feature of flu." all infectionss source is waited the opinion wind heat and waited " has certain description to the origin cause of formation and the Clinical symptoms of affection due to external wind and heat again.Yuan Dynasty's " danxi's experiential therapy invasion by pathogenic cold appendix " has proposed flu to be thought by mistake the ring of typhoid fever, and the hot temperature of treatment flu, hot cool two big rules." the attached wind of Wanbing Huichun, Curative Measures for All Diseases typhoid fever " is pointed out: " pestilent cold wind and cold person should be induced sweat also." point out inducing diaphoresis to expel pathogens treatment flu.Outside " card is controlled to converge and mended cold " the exorcising invasion and attack of pointing out to catch a cold, also reach relevant without hesitation with the power of body constitution.In sum, Gan Mao the cause of disease to be experiencing ailment said due to cold or exposure as can be known, but normal relevant closely with human righteousness's power.The flesh table is mainly defended at lung in its sick position, treatment should be dispersed to induce sweat, dialectically should at first distinguish wind and cold, wind-heat syndrome, also should belong to void, true according to body constitution and symptom performance then, treatment is a rule with relieving the exterior syndrome with drugs of pungent in flavor and warm in nature and relieving the exterior syndrome with drugs of pungent in flavor and cool in nature mainly, modern medicine thinks that affection due to external wind and heat is a kind of disease " card " of Chinese medicine, belongs to upper respiratory tract infection.Commonly encountered diseases because of be by virus, minority causes by virus, virus mainly is that influenza virus (first, second, third), parainfluenza virus, breathing move back syncytial virus, adenovirus etc., bacterial infection can directly take place or secondary.See with hemolytic hammer Seedling more.As inducements such as suffering from cold, drench with rain, be overtired, when whole body or respiratory tract local defense ability are reduced, be stored in upper respiratory tract or can breed rapidly and cause from the virus of outer intrusion or antibacterial.Its pathology is from nasal cavity and throat take wing film hyperemia, edema, and epithelial cell destroys, and a small amount of monocyte infiltration has serosity and portion's fluidity to ooze out.But the primary disease secondary becomes acute bronchitis and causes cough: cause to breathe and move back infection, also cause organism immune response to cause Urinary system inflammation sometimes.Primary disease can annual take place, and can repeatedly take place, and more sees with two seasons of Winter-Spring especially more.Wind is first of the six climate exopathogens, among flowing in 4 o'clock, is the guide of primary disease morbidity.Again because of four o'clock six gas respectively have inclined to one side Sheng, thus normal again gas or the gas phase when non-with in season of ailment said due to cold or exposure close and hurt sb.'s feelings, so clinical manifestation is different pattern of syndrome.In the winter in late autumn, ailment said due to cold or exposure easily is harmonious with cold, the anemofrigid cold card occurs; Spring and summer warm season, ailment said due to cold or exposure is harmonious with heat easily, anemopyretic cold occurs and demonstrate,proves.In addition, more than two cards, also can press from both sides wet or hold concurrently dry.If the time row virus hurt sb.'s feelings, it is generally heavier and changeable then to demonstrate,prove feelings, often infects mutually, is widely current.As Sui Dynasty " disorder of QI duke or princess under an emperor during the General Treatise on the Cause and Symptoms of Diseases " said husband's seasonal epidemic pathogens patient, this all because of the year time get along well, temperature is cool forfeits one's integrity, the people feels the gas of well-behaved celebrating and gives birth to, the patient is heterogeneous dyes easy.”
The medicine of relevant treatment flu is more, and at present common have cold capsule, contac, paracetamol, bufferin, a GANMAOTONG etc., and Chinese medicine preparation also has much, for example WEI C YINQIAO PIAN, Radix Isatidis granules, cold drug sheet, Lonicerae and Forsythiae Powder etc.Open source literature has also been reported the Chinese medicine preparation of a lot of relevant treatment flu, for example:
1, the development of [autograph] cold drug oral liquid and clinical practice [author] Si Tianrun healthy [periodical name] Chinese Pharmaceutical Journal .1995,30 (8) .-470-472[digests] preparation technology and the clinical practice of cold drug oral liquid (child form) are studied.This oral liquid is by Flos Lonicerae, Fructus Forsythiae, and Radix Isatidis, Gypsum Fibrosum, pure Chinese medicine such as Rhizoma Phragmitis is formed, and has determined quality control standard.Use through clinical 30 routine infants, the rate 100% of bringing down a fever in the 3d, cure rate 93.3% in the 5d, effect is satisfied.
2, Study on Preparation [author] Wang Deqin of [autograph] cold drug sheet once made outstanding Chen Song light Yang Dong liter [mechanism] Baiyunshan Pharmaceutical Factory of Traditional Chinese Drug, Baiyunshan Pharma, [periodical name] Chinese patent medicine .2004,26 (7) .-589-590[digests] the cold drug sheet is " Guangdong Province's drug standard " kind that the version first volume recorded in 1987, by Flos Ilicis Asprellae, Foliumet Ramulus Evodiae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Flos Chrysanthemi Indici, Oleum menthae, caffeine, Chinese and western drugs such as chlorphenamine maleate and acetaminophen is made, effect with antipyretic-antalgic, be used for clinically because of having a headache and fever that flu causes, nasal obstruction, watery nasal discharge, diseases such as pharyngalgia.This paper is by orthogonal experiment, screening and optimizing the extraction process condition, investigated suitable adjuvant prescription, worked out quality standard, be to guarantee preparation matter
3, antiinflammatory of [autograph] flu side and analgesic activity research [author] Ni Wen clinical research institute of strong [mechanism] Jiangsu TCM Hospital of Zhu Xuan tawny daylily Zhang Zhonghua Diao Pin that splashes, [periodical name] practical tcm internal medicine magazine .2004,18 (6) .-503-504[digests] flu side is the Chinese medicine preparation of my institute exploitation advantage characteristic, this side is made up of Flos Lonicerae, Fructus Forsythiae, Herba Schizonepetae etc., is that Lonicerae and Forsythiae Powder forms in conjunction with the clinical experience sanction.Cure mainly diseases such as anemopyretic cold generates heat, has sore throat, malasia, cough.Flu side cures mainly relevant effect with clinical function for checking, has carried out following experimentation:
4, antiviral experimentation [author] the Zhang Zhonghua Zhu Xuan tawny daylily Ni Wen of [autograph] the flu side medicine clinical research institute of [mechanism] Jiangsu TCM Hospital that splashes, [periodical name] practical tcm internal medicine magazine .2005,19 (4) .-323-324[digests] be the Chinese medicine preparation of exploitation advantage characteristic, be expounded through peer review to discuss through my institute and draft flu side. ourly form, cure mainly diseases such as anemopyretic cold generates heat, has sore throat, malasia, cough by Flos Lonicerae, Fructus Forsythiae, Herba Schizonepetae, Radix Isatidis etc.This side has antiinflammatory and antibacterial action preferably after deliberation, and flu side cures mainly relevant effect with clinical function for checking. its antivirus action has been carried out experimentation.
6, Chinese patent, application number: 03117135.4 applying date: 2003.01.07 title: Chinese medicine preparation of treatment anemofrigid cold and preparation method thereof application (patent right) people: Guizhou National Pharmaceutical Factory address: 8F, Yinhai Building, No.18, Zhonghuabei Road, Guiyang City, Guizhou Province invention (design) people: Shi Hongyi; Summary: the present invention is a kind of Chinese medicine preparation for the treatment of anemofrigid cold and preparation method thereof, Herba Kalimeridis grass is crushed into fine powder, Herba Lysionoti Pauciflori, Radix Chimonanthi praecocis, Radix seu Herba Gei aleppici, bark of Semen Caesalpiniae, Folium Perillae, the technology of Herba Schizonepetae water or alcohol extraction extracts active ingredient, then with Herba Kalimeridis grass fine powder mix homogeneously, dry, pulverize, be made into the dosage form that needs again, compared with prior art: the present invention makes of pure Chinese herbal medicine, its curative effect is obvious, there is not toxic and side effects, there is not drowsiness composition in the medicine simultaneously, with low cost, preparation method is easy, easily accepted by the patient, medicine has relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, the effect of lung qi dispersing cough-relieving is used for the treatment of the headache that anemofrigid cold occurs, fever with aversion to cold, watery nasal discharge, symptoms such as cough, medicine have obtained the production permit of national departments concerned.
6, Chinese patent, application number: the 01129082.X applying date: 2001.11.15 title: a kind of medicine and production method application (patent right) people thereof who prevents and treats affection due to external wind and heat: Guilin Sanjin Pharmaceutical Group Co., Ltd address: No. 1, Jinxing Road ,Guilin City ,Guangxi Zhuang Autonomousnationality District, summary: the invention provides a kind of Chinese medicine preparation of preventing and treating affection due to external wind and heat and sunstroke prevention.Its prescription is: seven flavor Chinese medicines such as Radix Mussaendae, Flos Ilicis Asprellae, Flos Lonicerae, Radix Helicteris, Flos Chrysanthemi, Herba Centellae, Flos Chrysanthemi Indici form according to the scientific and reasonable collocation of Chinese medical theory.Its production method is preparations such as the granule that said medicine utilized modern pharmaceutical production technologies such as water is carried, precipitate with ethanol make, syrup, oral liquid, tablet, capsule, this medical instrument has the effect of heat-clearing and toxic substances removing, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, secretion replenishing and throat moistening, clearing away summer-heat and eliminating dampness, cure mainly flu, cough, pharyngolaryngitis, urinary tract infection that affection due to external wind and heat causes, and sunstroke prevention.Evident in efficacy, treat the disease spectrum width, giving consideration to both the exterior and interior.
7, Chinese patent, application number: 02127947.0 applying date: 2002.12.04 title: a kind of pharmaceutical composition application (patent right) people: Xie Xiuqiong that treats flu; Guo Dongyan; The Luo Haiyan address: No. 6 summaries in Chengdu, Sichuan Province Jinniu District QINGYANG Unit 3, one tunnel No. 9 14 building, east the invention discloses a kind of pharmaceutical composition for the treatment of flu, and especially relating to a kind of is the Chinese medicine preparation of the treatment flu of feedstock production by Chinese medicine.Pharmaceutical composition provided by the invention is the medicament by the feedstock production of following weight ratio: Fructus Forsythiae 10-20 part, Radix Saposhnikoviae 6-15 part, Rhizoma Atractylodis 6-15 part, Fructus Viticis 6-15 part, Rhizoma Belamcandae 10-15 part, Radix Glycyrrhizae 1-5 part.Fructus Forsythiae, the Fructus Viticis of the hot cold in full side, with hot using warming therapy Radix Saposhnikoviae, the same usefulness of Rhizoma Atractylodis, Xin Wen is not and scorching, cold and cool and not sluggish, and its meaning focuses on dispels the wind by evil, and Xin Pingbiao looses, so various flu all should be used
8, Chinese patent, application number: the 200310122718.X applying date: 2003.12.19 title: a kind of Chinese medicine preparation and preparation method for the treatment of respiratory tract infection and viral influenza, application (patent right) people: Xingling Sci. ﹠ Tech. Pharmaceutical Co., Ltd., Shanghai address: No. 1271,200127 Shanghai City Pudong Dongfang Road, summary: the present invention relates to a kind of Chinese medicine preparation and preparation method for the treatment of respiratory tract infection and viral influenza.Said preparation is to be the oral formulations that active component is made with Herba Schizonepetae, Flos Lonicerae, Ilex purpurea Hassk.[I.chinensis Sims, Herba Houttuyniae, Folium Isatidis, Herba Taraxaci, Radix Saposhnikoviae, Fructus Arctii and Radix Glycyrrhizae.The present invention prescription has the dispelling wind expelling pathogenic factors from the exterior, heat-clearing and toxic substances removing, and the merit of lung qi dispersing sore-throat relieving is used for the treatment of anemopyretic cold and violates heating, pharyngalgia, cough due to exterior syndrome and the wind-warm lung-heat disease syndrome of wind-heat invading lung.The hot cold of prescription is then flat, and bitter cold is then fallen, and tool is made a distinction between the important and the lesser one, treating both the principal and secondary aspects of a disease, eliminating evil and do not hinder positive characteristics.
9, Chinese patent, application number: 03100188.2 applying date: 2003.01.09 title: a kind of Chinese medicine composition for the treatment of anemopyretic cold and preparation method thereof application (patent right) people: Lunan Pharmacy Co. Ltd address: one tunnel No. 107 summary in Linyi City Linxi, Shandong Province: the invention discloses a kind of Chinese medicine composition for the treatment of anemopyretic cold and preparation method thereof.Said composition is made up of Radix Bupleuri, Flos Lonicerae, Radix Scutellariae, Radix Puerariae, Herba Schizonepetae, Herba Artemisiae Annuae, Fructus Forsythiae, Radix Platycodonis, Semen Armeniacae Amarum, Herba Menthae, Herba Houttuyniae.When this Chinese medicine composition prepares different component is adopted the method for distillation, decoction, ethanol extraction, reach and make giving full play to of active drug.This combination treatment anemopyretic cold has good effect.
10, Chinese patent, application number: 200410028171.1 applyings date: 2004.07.22 title: medicine of treatment viral influenza and preparation method thereof application (patent right) people: Science ﹠ Technology Industry Garden Co Ltd, Guangzhou Traditional Chinese medic address: Yongxing village, Baiyun District Longgui town, GuangZhou, Guangdong Province city, summary: the invention discloses a kind of medicine for the treatment of viral influenza and preparation method thereof, it adopts patchouli oil, Oleum menthae, Flos Lonicerae, Folium Mori, Herba Taraxaci, Flos Chrysanthemi Indici, Rhizoma Imperatae, Semen Armeniacae Amarum, Semen Persicae, Semen Benincasae, Herba Artemisiae Annuae, Radix Platycodonis, Semen Coicis, Radix Glycyrrhizae is prescription in proportion, through selecting materials, clean, dry, soak, extract, filter, concentrate, drying is prepared from; Medicine wind-dispelling heat-dissipating of the present invention, fragrant damp eliminating, removing pathogenic heat from blood and toxic substance from the body.It is evident in efficacy to be used for viral influenza.
The weak point that the Chinese medicine preparation of the treatment flu of above-mentioned open source literature report exists is: the prescription more complicated that has, the therapeutic effect that has is remarkable inadequately, curative effect is slower, what have has a drowsiness side effect of Denging, so the medicine of the treatment flu mainly used of pharmacy and hospital is still more with cold capsule, contac, paracetamol, GANMAOTONG, WEI C YINQIAO PIAN, Radix Isatidis granules, cold drug sheet at present.
Summary of the invention
The purpose of this invention is to provide a kind of characteristics at the flu disease, it is effective to treat various types of flu, safety, Chinese medicine preparation that has no side effect and production method thereof.
The present invention treats the Chinese medicine preparation of flu and is made by following parts by weight of traditional Chinese medicines:
Blank sheet of paper fan 12-22 part, Cortex schefflerae octophyllae 20-35 part, Radix Platycodonis 5-10 part, Herba Artemisiae Annuae 12-22 part, Radix Helicteris 6-12 part, Radix Isatidis 12-22 part, Radix Glycyrrhizae 3-8 part.
In addition, can also add ephedrine hydrochloride 0.1-0.2 part, ginger tincture 0.1-0.2 part, Oleum menthae 0.1-0.2 part, eucalyptus oil 0.1-0.2 part.
Add these a spot of ephedrine hydrochlorides, ginger tincture, Oleum menthae, eucalyptus oil, the merit of relieving the exterior syndrome by diaphoresis is arranged, can strengthen curative effect.
Above-mentioned Chinese medicine all can be found its another name or Latin from Chinese medicine pharmacopeia or Chinese herbal medicine handbook, and the place of production, function, usage.For understanding drug action mechanism of the present invention, the performance of taking passages each Chinese medicinal ingredients is as follows:
The blank sheet of paper fan, Latin: M.kwangtungensis Li. formal name used at school: Guangdong Radix Mussaendae, another name: Radix Mussaendae, Ramulus et Folium Mussaendae Pubescentis, herbal tea rattan, butterfly rattan.Form: climbing shrub, sprig be by pubescence, the leaf egg shape Long Circle, and long 4-8cm, the back side is by pubescence.Dense corymb is spent 5 pieces, the calyx tube gyroscope-like, and the sliver bar shaped, there have 1 piece of sliver often to expand as to be lobate, white; The corolla yellow.Fruit is spherical, and bloom summer.
Function with cure mainly: sweet, little hardship, cold.Clearing away summer-heat, the damp eliminating detumescence.Control dysentery, chronic persistent hepatitis, heatstroke, bronchitis, pain in the lung, pyelonephritis, rheumatic arthralgia, acute tonsillitis, otitis media, wind-fire acute conjunctivitis, Maninot esculenta crantz., mushroom poisoning etc.
Cortex schefflerae octophyllae, Cortex schefflerae octophyllae Taxillus chinensis (DC.) Danser, another name: western Cortex Acanthopanacis Radicis, duck foot skin, Cortex schefflerae octophyllae, Psychotria rubra (Lour.) Poir. cattle, Chinese peach tree, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), river wood mother.Shape: be root bark, the peel of stem of Araliaceae schefflera platymiscium schefflera.Aiphyllium or big shrub, high 2-15m, the diameter of a cross-section of a tree trunk 1.3 meters above the ground can reach more than the 30cm.The bark canescence, branch is sturdy, oily at ordinary times wrinkle.The palmately compound leaf alternate, lobule 6-9, petiole is elongated, cylindric long 15-30cm, the long 2-5cm of petiolule, lobule ellipse, oblong, long 9-17cm, wide 3-5cm, tip point.Inflorescence is that give birth on the large-scale panicle of umbrella shape flower consor top.Mainly originate in ground such as Guangxi, Guangdong.Medicinal dried bark in the form of a roll or the channel plates bulk, long 30-50cm, thick 2-8mm, outer surface canescence or lead, rough, the lichens speckle is often arranged.Feeble QI perfume (or spice), little hardship, puckery.Main component: oleanolic acid, 32-hydroxyl plumage Seem Lablab Album-20 (29)-alkene-23,28-diacid.
Effect with cure mainly: hot, bitter, cool.Clearing away heat and expelling pathogen in the exterior, expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.The diseases such as heating, laryngopharynx swelling and pain, scald, innominate toxic swelling, herpes zoster, rheumatic arthralgia, traumatic injury, fracture of curing cold.
Radix Platycodonis, (Platycodon grandiflorus) another name hexagonal lotus, Radix Platycodonis, burden flower, Dao Laji belong to campanulaceae, Platycodon grandiflouorum.Shape: be perennial herb, high 40-120cm, tool white milk.The main root hypertrophy, cylindric, conico-acuminate or long spindle, few branch.Stem is upright, usually not branch or top oil content branch.Stem upper leaf alternate, middle and lower part leaf be to giving birth to or verticillate, stockless or oily short handle, and leaf is avette to ovum shape branch aciculiform, long 3-7cm, wide 1-3cm.The tip point, the base portion wedge shape, there is irregular sharp sawtooth at the edge, below by white lead.Hua Dansheng or piece be gathered into to dredge and give birth to raceme.Calyx mitriform, long 8-10cm, the corolla blueness, bluish violet or adularescent, wide mitriform, diameter 4-6cm, top 5 is split, the sliver triangle.Capsule falls oval.Florescence 7-10 month, the fruit phase 8-11 month.
Main chemical compositions: the multiple triterpenoid saponin of root mainly contains Radix Platycodonis glycoside D.Pharmacology: analgesic, antiinflammatory, antitussive, eliminate the phlegm, antiallergic, analgesia, calmness etc.But blood flow increasing, reduction coronary artery and hind leg vascular resistance, other has hypoglycemic activity.Effect with cure mainly: bitter in the mouth, suffering, property are flat.Lung qi dispersing eliminates the phlegm, the sore-throat relieving evacuation of pus.Control cough ant phlegm, chest and diaphragm full vexed, pharyngalgia is silent, clinical adaptation pharyngitis, tonsillitis, acute/chronic bronchitis etc.
Herba Artemisiae Annuae, Latin title: Artemisia annua L.[another name] Herba Artemisiae annuae, smelly Artemisia, be shaped as annual herb, high 30-150cm.Stem is upright, and is cylindrical, and the surface has thin pod, multi-branched, smooth no hair.The leaf alternate, green when tender, yellowish-brown when old does not have hair.Blade is back pinnation, long 3-6cm, and wide 2-3cm, sliver is short and thin, and the tip point has minimum powder pubescence, back side light green, the tiny gland shape of tool speckle.The narrow wing of rachis both sides tool.Head inflorescence is arranged in taper shape, and each head inflorescence adnation is sagging slightly.The achene square is circular to oval, and is small, brown.
Main chemical compositions: arteannuin, artemisilactone, artelinic acid etc., volatile oil close multiple compositions such as artemisia ketone, different artemisia ketone, cineole, left family Camphora.Pharmacology: 1. antitumaous effect.2. discoid lupus erythematosus has certain curative effect.3. imago of blood fluke had killing action.4. volatile oil is effective to chronic tracheitis.Effect with cure mainly: bitter in the mouth, little suffering, cold in nature.Clearing away summer-heat is arranged, remove the effect of steaming.Control diseases such as hectic fever due to YIN-deficiency consumptive fever, malaria, heatstroke, damp disease, dysentery, scabies, pruritus.
Radix Helicteris, Sterculiaceae plant, Helicteres angustifolia L. another name: Folium Trematis Dielsianae, sloping spunyarn, Amauroderma ruda (Berk) Pat fiber crops, spunyarn first.Form: undershrub, Herb is by yellow green fine hair or crown hair.The long and narrow circle of leaf, long 3.5-5cm.Cyme; Squamella 4; The calyx tubulose, 5 split; Petal 5; Stamen 10.Capsule is close by stellate hair.Bloom summer.
Effect with cure mainly: bitter, little sweet, cold.Clearing away heat and expelling pathogen in the exterior, heat-clearing and toxic substances removing.Control measles, dysentery, gastroenteritis, lymphoid tuberculosis, tonsillitis, pharyngolaryngitis, eczema, carbuncle, hemorrhoid, arthritis etc.
Radix Glycyrrhizae, Glycyrrhiza uralensis Fisch.[another name] the Herba Hedyotis cantonensis root; Radix Glycyrrhizae; Radix Glycyrrhizae; Rhizoma sacchari spontanei, shape: perennial herb, high 30-80cm, rhizome is yellow old.Stem is by undercoat, strange piece of winglike compound leaf, lobule 15-17, long narrow avette, obovate or oblong, the raceme axil is given birth to, and is short than leaf, spend intensive, calyx mitriform.Pod is flat, seed 2-8, oblateness or kidney shape.The florescence 6-7 month, the fruit phase 7-9 month.
Main chemical compositions: licorice contains the triterpenoid compound glycyrrhizin, mainly is the potassium calcium salt of glycyrrhizic acid, also has 24-hydroxyl enoxolone etc. and flavone compound etc. in addition.Pharmacology: gastrointestinal smooth muscle is had spasmolysis, mineralocorticoid and glucocorticoid effect, anti-inflammatory, antiallergic, antitussive effect are arranged, poisoning is had Detoxication, various bacteria is had bacteriostasis.Effect with cure mainly: sweet in the mouth, property are flat, invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, the emergency analgesic therapy is in harmonious proportion the property of medicine etc.Control weakness of the spleen and stomach, deficiency of QI in middle-JIAO, cough and asthma, sore, contraction is anxious in the abdomen has a pain, and it is strong to relax the property of medicine, separates poison of drug etc.
Radix Isatidis, Radix Isatidis[English] Indigowoad Root, call indigo-blue, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, indigo root, shape: former plant is the dry root of cruciferae isatis.Isatis indigotica Fort. is a biennial herb, and the smooth nothing hair of plant often is with the white lead frost, high 50-100cm, root taper shape, long 20-40cm, diameter 2-3cm.The basal leaf rosette-stape has handle, the extremely wide lanceolar of lobate Long Circle, and long 5-14cm, wide 1.5-4cm, the top is blunt or sharp, and base portion is gradually narrow; The stem leaf aeruginous, the nearly Long Circle of blade, long 6-15cm, wide 1-4cm.Give birth on the raceme top and axil is given birth to, poly-coning on the branch top.The nearly Long Circle of silicle, long 9-25mm, wide 5-7mm, flat, there is not hair, carpopodium is elongated, and is little sagging, seed, Long Circle, filbert, long 3-3.5mm, the florescence 4-5 month, the fruit phase 5-6 month.The medical material character: the root taper shape, distortion slightly, long 10-20cm, diameter 0.3-1.2cm, surperficial lark is by vertical wrinkle.And the faint yellow hole skin of growing crosswise arranged.The root head slightly expands. the green petiole residual base of the vinegar that visible colyliform is arranged, stipe scar and intensive verruca, and body is real, and matter is slightly soft, and fracture is slightly smooth, and the light brown white of skin zone accounts for 1/2 to 1/3 of radius, the woody part yellow to light brown.Feeble QI, it is little sweet then puckery to distinguish the flavor of, and does with body, and bar is long, and is thick, and body reality person is good.
Nature and flavor and function: bitter, cold, GUIXIN, stomach warp.Heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving.The effect that heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving are arranged is used for maculae caused by violent heat pathogen, tongue and falls purple dark, mumps, sore throat, scarlet fever, erysipelas, carbuncle etc.
Ginger tincture is the tincture of Rhizoma Zingiberis Recens Zingiber officinale Rosc fluid extract through being processed into.Character: be flaxen liquid; The fragrance that Rhizoma Zingiberis Recens is arranged, it is peppery to distinguish the flavor of.Function with cure mainly: wind dispelling is good for the stomach.
Ephedrine hydrochloride (ephedrine hydrochloride) Ephedrine Hydrochloride (Ephetonin) [effect and purposes] ephedrine can directly act on two kinds of receptors of α, β, the effect of performance adrenomimetic drug, also can impel the adrenergic nerve tip to discharge chemical mediator, bring into play the adrenomimetic drug effect indirectly.Compare with epinephrine, the characteristics of ephedrine are stable in properties, and oral effectively effect is weak and lasting, and the central excitation effect is more remarkable.Have effects such as loose bronchial smooth muscle, excited heart, vasoconstrictive, rising blood pressure.Clinically be used for the hypotension that bronchial asthma, subarachnoid anesthesia or epidural anesthesia cause and remove nasal mucosa hyperemia, edema.
Oleum menthae, also claiming Oleum menthae [English name] OLEUM MENTHAE DEMENTHOLATUM[source] this product is fresh stem and the Ye Jing vapor distillation of labiate Herba Menthae Mentha haplocalyx Briq., freezing again, part is taken off the volatile oil that brain processing obtains.Character, this product are colourless or flaxen supernatant liquid.Special refrigerant fragrance is arranged, and flavor is just hot, the back is cool.Deposit with the passing of time, the color gradual change is dark.This product can be mixed arbitrarily with ethanol, chloroform or ether.
Eucalyptus oil Oil of Eucalyptus (Eucaly Ptus Oil), (cineole content is minimum be 80% eucalyptus oil),, make through refining processing again from Eucalyptus globulus Labill (Eucalyptus globules Labill) or contain the leaf, branch of some Lignum cinnamomi camphorae kind of cineole and extract quintessence oil with steam distillation.Colourless or the faint yellow mobile liquid of character.Characteristic perfume with cineole has a Camphora and medicinal herbs breath.Cool flavor is arranged.
The present invention adds ephedrine hydrochloride, ginger tincture, Oleum menthae, and the effect of eucalyptus oil is the merit that relieving the exterior syndrome by diaphoresis is arranged, and strengthens curative effect, can add in preparation tablet, capsular process.Powder, granule can not add.
The present invention compared with prior art, its outstanding substantive distinguishing features and obvious improvement is:
From the angle of the traditional Chinese medical science, the symptom of flu has heating, headache, cough.From modern medicine, flu is caused by virus that mostly part also has infectiousness, endangers very big.The part medicine has antivirus action among the we, thereby disease is controlled.We reach the purpose of treatment by heat-clearing and toxic substances removing, dispelling wind cough-relieving.Also by making patient's diaphoresis, patient's whole body feels happy to we after the diaphoresis, and flu promptly takes a turn for the better fast.This also is the characteristics of this medicine.The flu patient is not owing to perspire, and refuse can not be drained in the body, and the state of an illness is difficult to take a turn for the better.
The various dosage forms that the above-mentioned Chinese medicine of the present invention can be prepared into granule, tablet, capsule, pill, oral liquid or pharmaceutically be suitable for below are the preparation methoies of some dosage forms:
One, the production method of granule and technological process
1. title medicine: blank sheet of paper fan 12-22 part, Cortex schefflerae octophyllae 20-35 part, Radix Platycodonis 5-10 part, Herba Artemisiae Annuae 12-22 part, Radix Helicteris 6-12 part, Radix Isatidis 12-22 part, Radix Glycyrrhizae 3-8 part.
2. water extraction: above Chinese medicine → put is in the Chinese medicine extraction jar → add 10-15 times of water → heated and boiled 1-2 hour → and emit medicinal liquid → medicinal cupping and add 5-10 times of water gaging → reheating and boil 0.5-1 hour → medicinal liquid and emit filtration → medicinal liquid
3. medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating is concentrated into 2-3 times of medicine volume → cooling.
4. ethanol precipitation: 95% ethanol to the concentration of alcohol of 3 times of amounts of medicinal liquid → add reach be put in after 60-70% → stirring 4-8 ℃ → leave standstill 12-24 hour → filter.
5. recovery ethanol: filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooled and filtered → medicinal liquid.
6. medicinal liquid concentrates: and medicinal liquid → put is in the concentration pan → and heating concentrate → obtains the cream drug that relative density is 1.10-1.15 (80 ℃).
7. granulate: cream drug → with sucrose is by 2 times (according to gross weights of crude drug) according to the gross weight of crude drug; above-mentioned medicated powder also can add ephedrine hydrochloride 0.1-0.2 part (according to the gross weight of crude drug; below identical), ginger tincture 0.1-0.2 part; Oleum menthae 0.1-0.2 part; eucalyptus oil 0.1-0.2 part is mixed; drying obtains medicated powder → granulator and granulates.Then quantitatively → and encapsulation → finished product → packing, obtain the granule finished product.
Two, the production method of capsule and technological process:
1. title medicine: blank sheet of paper fan 12-22 weight portion, Cortex schefflerae octophyllae 20-35 weight portion, Radix Platycodonis 5-10 weight portion, Herba Artemisiae Annuae 12-22 weight portion, Radix Helicteris 6-12 weight portion, Radix Isatidis 12-22 weight portion, Radix Glycyrrhizae 3-8 weight portion.
2. water extraction: above Chinese medicine → put is in the Chinese medicine extraction jar → add 10-15 times of water gaging → heated and boiled 1-2 hour → and emit medicinal liquid → filtration → medicinal residues and add 5-10 times of water gaging → add thermogravimetric and boil 0.5-1 hour → medicinal liquid and emit → filter → medicinal liquid.
3. medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating concentrates → to 2-3 times of medicine volume → cooling.
4. ethanol precipitation: above medicinal liquid → add 95% ethanol to concentration of alcohol reaches 4C ° of 60-70% → stir → put-8C ° and leaves standstill 12-24 hour → filtration → filtrate.
5. recovery ethanol: above filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooling → filtration → medicinal liquid
6. medicinal liquid concentrates: and above filtrate → put is in the concentration pan → and heating concentrate → obtains the cream drug that relative density is 1.10-1.15 (80 ℃).
7. pharmacy powder: above cream drug → add adjuvant → powder process drying → obtain medicated powder.
Above-mentioned medicated powder also can add ephedrine hydrochloride 0.1-0.2 part (according to the gross weight of crude drug, below identical), ginger tincture 0.1-0.2 part, Oleum menthae 0.1-0.2 part, and eucalyptus oil 0.1-0.2 part is mixed, and drying obtains medicated powder.
8. glue capsule and sealed cans: glue capsule → tin seamer upper closure cans on above medicated powder and the appropriate amount of auxiliary materials mixing → capsule machine → obtain capsule finished product.
Above-described adjuvant is a magnesium stearate, or meets other adjuvant of international and national Specification.It is 3-15% that adjuvant adds mass content.
Three, the production method of tablet and technological process
Medicated powder with the 7th step obtained in the production method of above-mentioned capsule adds right amount of auxiliary materials, and mixing is granulated, drying, and tabletting, coating, packing promptly gets tablet.
Described adjuvant is the pharmaceutic adjuvant of various medical standard universals, comprises filler, disintegrating agent, lubricant etc., and filler is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Disintegrating agent is Sodium Tvlose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Lubricant is the pharmaceutic adjuvant of Polyethylene Glycol, magnesium stearate, Pulvis Talci and tool lubrication.Wherein the weight content of filler, disintegrating agent, lubricant is respectively 30-55%, 3-15%, 0.3%-0.6%.
Four, the production method of pill and technological process
Cream drug with the 6th step obtained in the production method of above-mentioned capsule adds right amount of auxiliary materials, and mixing is done binding agent with water, Mel or water and Mel and is prepared into ball, and packing promptly.
Above-mentioned tablet, pill can adopt the medicated powder that adds ephedrine hydrochloride 1-2 weight portion, ginger tincture 1-2 weight portion, Oleum menthae 1-2 weight portion, eucalyptus oil 1-2 weight portion, also can not add these materials.
Five, the production method of oral liquid and technological process
With the cream drug that the 6th step obtained in the production method of above-mentioned capsule, the sucrose that adds 3 times of weight is mixed, adds 5-6 pure water doubly again, makes oral liquid.
The specific embodiment
Embodiment 1
Take by weighing 12 kilograms on blank sheet of paper fan, 20 kilograms of Cortex schefflerae octophyllaes, 5 kilograms of Radix Platycodoniss, 12 kilograms of Herba Artemisiae Annuaes, 6 kilograms of Radix Helicteriss, 12 kilograms of Radix Isatidis, 3 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan, heating concentrates again, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), with 50 kilograms of sucrose, add ephedrine hydrochloride 50g, ginger tincture 15ml, Oleum menthae 15ml, eucalyptus oil 15ml → granulator is granulated.Then quantitatively → and encapsulation → finished product → packing, obtain the granule finished product.
Embodiment 2
Take by weighing 20 kilograms on blank sheet of paper fan, 30 kilograms of Cortex schefflerae octophyllaes, 8 kilograms of Radix Platycodoniss, 20 kilograms of Herba Artemisiae Annuaes, 10 kilograms of Radix Helicteriss, 20 kilograms of Radix Isatidis, 5 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan, heating concentrates again, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), with 80 kilograms of sucrose, add ephedrine hydrochloride 15ml, ginger tincture 15ml, Oleum menthae 15ml, eucalyptus oil 15ml → granulator is granulated.Then quantitatively → and encapsulation → finished product → packing, obtain the granule finished product.
Embodiment 3
Take by weighing 15 kilograms on blank sheet of paper fan, 25 kilograms of Cortex schefflerae octophyllaes, 6 kilograms of Radix Platycodoniss, 18 kilograms of Herba Artemisiae Annuaes, 8 kilograms of Radix Helicteriss, 18 kilograms of Radix Isatidis, 4 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan again, heating concentrates, obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), add ephedrine hydrochloride 10ml, ginger tincture 10ml, Oleum menthae 10ml, eucalyptus oil 10ml, glue capsule → tin seamer upper closure cans on above medicated powder and the 5 kilograms of magnesium stearate mixing → capsule machines → obtain capsule finished product.
Embodiment 4
Take by weighing 15 kilograms on blank sheet of paper fan, 25 kilograms of Cortex schefflerae octophyllaes, 6 kilograms of Radix Platycodoniss, 18 kilograms of Herba Artemisiae Annuaes, 8 kilograms of Radix Helicteriss, 18 kilograms of Radix Isatidis, 4 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan, heating concentrates again, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), glue capsule → tin seamer upper closure cans on above medicated powder and the 5 kilograms of magnesium stearate mixing → capsule machines → obtain capsule finished product.
Embodiment 5
Take by weighing 22 kilograms on blank sheet of paper fan, 30 kilograms of Cortex schefflerae octophyllaes, 10 kilograms of Radix Platycodoniss, 20 kilograms of Herba Artemisiae Annuaes, 10 kilograms of Radix Helicteriss, 21 kilograms of Radix Isatidis, 6 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan again, heating concentrates, obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), add ephedrine hydrochloride 18ml, ginger tincture 18ml, Oleum menthae 18ml, eucalyptus oil 18ml, above medicated powder and 5 kilograms of starch, 3 kilograms of Sodium Tvlose, 0.5 kilogram of Polyethylene Glycol mixing are granulated, dry, tabletting, coating, packing promptly gets tablet.
Embodiment 6
Take by weighing 15 kilograms on blank sheet of paper fan, 25 kilograms of Cortex schefflerae octophyllaes, 6 kilograms of Radix Platycodoniss, 18 kilograms of Herba Artemisiae Annuaes, 8 kilograms of Radix Helicteriss, 18 kilograms of Radix Isatidis, 4 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan, heating concentrates again, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), above medicated powder and 5 kilograms of magnesium stearates, 3 kilograms of carboxymethyl starches, 2 kilograms of Sodium Tvlose mixings are granulated drying, tabletting, coating, packing promptly gets tablet.
Embodiment 7
Take by weighing 15 kilograms on blank sheet of paper fan, 35 kilograms of Cortex schefflerae octophyllaes, 10 kilograms of Radix Platycodoniss, 20 kilograms of Herba Artemisiae Annuaes, 7 kilograms of Radix Helicteriss, 18 kilograms of Radix Isatidis, 5 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan again, heating concentrates, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), adds ephedrine hydrochloride 15ml, ginger tincture 15ml, Oleum menthae 15ml, eucalyptus oil 15ml, do binding agent with water, Mel or water, starch, raw sugar and be prepared into ball, packing promptly.
Embodiment 8
Take by weighing 13 kilograms on blank sheet of paper fan, 22 kilograms of Cortex schefflerae octophyllaes, 6 kilograms of Radix Platycodoniss, 13 kilograms of Herba Artemisiae Annuaes, 7 kilograms of Radix Helicteriss, 15 kilograms of Radix Isatidis, 3 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan again, heating concentrates, obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), with 80 kilograms of sucrose, add ephedrine hydrochloride 15ml, ginger tincture 15ml, Oleum menthae 15ml, eucalyptus oil 15ml, do binding agent with water, Mel or water, starch, raw sugar and be prepared into ball, packing promptly.。
Embodiment 9
Take by weighing 22 kilograms on blank sheet of paper fan, 30 kilograms of Cortex schefflerae octophyllaes, 10 kilograms of Radix Platycodoniss, 20 kilograms of Herba Artemisiae Annuaes, 10 kilograms of Radix Helicteriss, 21 kilograms of Radix Isatidis, 6 kilograms in Radix Glycyrrhizae.Above Chinese medicine → put in the Chinese medicine extraction jar adds 10-15 times of water, heated and boiled 1-2 hour, emits medicinal liquid, medicinal cupping adds 5-10 times of water gaging again, and reheating was boiled 0.5-1 hour, and medicinal liquid is emitted, filter medicinal liquid, medicinal liquid is put in the concentration tank, and heating is concentrated into 2-3 times of medicine volume, cooling.Medicinal liquid 95% ethanol to the concentration of alcohol that adds 3 times of amounts reaches 60-70% then, is put in 4-8C ° after the stirring, leaves standstill 12-24 hour, filters; Filtrate heating recovery ethanol, cooled and filtered gets medicinal liquid.Put in the concentration pan, heating concentrates again, and obtaining relative density is the cream drug of 1.10-1.15 (80 ℃), add ephedrine hydrochloride 18ml, ginger tincture 18ml, Oleum menthae 18ml, eucalyptus oil 18ml, it is mixed that above medicated powder adds 60 kilograms of sucrose, adds 5-6 pure water doubly, makes oral liquid.
Clinical data
Product of the present invention was produced and has been tested 4 years.Empirical tests, statistics cold, fever and cough case 100 examples, effective percentage is 94%, and the patient is generally reflected well.
Clinical observation on the therapeutic effect
1 clinical data
1.1 physical data
This data is totally 100 examples, wherein: male's 53 examples, women's 47 examples; 8～18 years old age person, 8 examples, 19～60 years old person's 70 example, person's 22 examples more than 60 years old; All belong to traditional Chinese medical science Common Cold patient.
1.2 diagnosis and case person standard adopt the inside and outside Gynecology ﹠ Pediatrics Dept. disease of State Administration of Traditional Chinese Medicine＜traditional Chinese medical science in 1988 to diagnose criterion of therapeutical effect〉in the diagnostic criteria of relevant Common Cold, as diagnostic criteria.Selection meets＜standard〉in the case of Common Cold diagnosis, get rid of endogenous cough and other non-exogenous diseases and lead
The Common Cold case, the issue of employing State Bureau of Technical Supervision＜tcm clinical practice diagnosis and treatment term syndrome part〉as dialectical standard.
1.3 clinical manifestation
This data 100 examples, all in various degree headache, heating, aversion to cold, nasal obstruction, watery nasal discharge, cough, pharyngalgia and general malaise being arranged all is feature, have a medical check-up visible nasal mucosa hyperemia, edema and more secretions, pharyngeal mild hyperaemia; Or it is cold to have the heating micro evil wind concurrently, the general pain pharyngalgia.Red tip of the tongue.Yellow and thin fur.All meet aforementioned diagnosis and person's standard.Dialectical result belongs to wind-cold affecting lung person's 68 examples, belongs to wind-heat invading the lung person's 32 examples.
100 examples are divided into treatment group and matched group at random.Wherein 60 examples are organized in treatment, matched group 40 examples.In the treatment group, male 32 examples, women 28 examples; 8～18 years old 5 age example, 18～60 years old 40 example, 15 examples more than 60 years old; Dialectical is Common Cold 40 examples, and cough person's 20 examples are arranged.
Male 21 examples in the matched group, women 19 examples; 9～18 years old 3 age example, 18～60 years old 30 example, person's 7 examples more than 60 years old; Dialectical is Common Cold 28 examples, and cough person's 12 examples are arranged.The equal not statistically significant of difference of two groups of case sexes, age, clinical syndrome differentiation typing has comparability.
3.2 Therapeutic Method
(1) treatment group: take cold drug.Be grown up each 3, every day 3 times, the child reduces by half.
(2) matched group: take tablet of the present invention, be grown up each 3, every day 3 times.The child reduces by half.
3.3 observation of curative effect
3.3.1 criterion of therapeutical effect
With reference to the inside and outside Gynecology ﹠ Pediatrics Dept. disease diagnosis of State Administration of Traditional Chinese Medicine＜traditional Chinese medical science in 1988 criterion of therapeutical effect〉[draw, carry out efficacy determination: 1. produce effects:
Clinical sign disappears; 2. take a turn for the better: cold cough alleviates, and amount of expectoration reduces;
3. invalid: symptom does not have improvement.
3.2 therapeutic outcome
Two groups of case curative effects relatively see Table 1.Two groups any toxicity all do not occur.
Table 1 therapeutic outcome synopsis
| The example number | Produce effects | Obvious effective rate | Take a turn for the better | Invalid | Total effective rate | |
| Treatment group matched group | 60 40 | 32. 5 | 53.33 12.5 | 25 27 | 3 8 | 95.00 80.00 |
Compare with matched group, P＜0.05,
*P＜0.01
As known from Table 1, two groups of curative effects are compared, the difference of its obvious effective rate, height statistical significance (P＜0.01) is arranged, and the difference of total effective rate has statistical significance (P＜0.05), prompting treatment group curative effect is better than matched group, illustrates that Chinese medicine preparation therapeutic effect of the present invention is better.
3.3 toxicity, two groups of patients there is no any toxicity in drug administration process
Concrete case
Case 1, Chen, man, 45 years old.First visit on April 10 in 2007.Fever with chills, lossless, the arthralgia of the extremities and irritability, it is low voice speaking to have a stuffy nose, thirsty pharyngalgia, it is vexed to cough, yellow fur, floating and rapid pulse, body temperature 40.5～C.Preceding medical Western medicine antipyretic and antibiotic therapy were not imitated in 2 days.Be diagnosed as the flu syndrome of superficies cold and interior heat, control with cold expelling and the clear interior-heat of inducing sweat.After adopting medicine of the present invention to take medicine 2 hours, sweating blows slowly, and all cards are gradually light.Examine on April 14 three: 37.3 ℃ of body temperature, clinical symptoms disappears substantially, takes medicine 2 doses again with clear surplus heresy and consolidate curative effect.
Case 2, patient Huang, conscious headache, heating, cough are diagnosed as flu.Exploitation Mingzhi treats the Chinese medicine preparation (granule) of flu, each 1 bag, and boiled water is taken after mixing it with water, and three times on the one, the clothes conscious perspiration in back, the transference cure two days later of taking medicine.
Case 3, patient's Wei, conscious cough, throat pain, slight heating, headache, outpatient service is sought medical advice in Affiliated Hospital, is diagnosed as flu, once took the commentaries on classics of not getting better of other coldrexs, back clothes tablet of the present invention, each 3, boiled water is taken after mixing it with water, three times on the one, perspire in clothes backs, serve on 2 days after, the transference cure recovery from illness.
The inventor thinks, Chinese medicine preparation of the present invention is multi-functional treatment flu and antipyretic Chinese medicine, the effect that not only has the expelling pathogenic factors from the exterior that induces sweat, and functions such as resolving heat and reducing pathogenic fire, removing pathogenic heat from blood and toxic substance from the body, removing dampness function of gallbladder promoting, saturating network detumescence are arranged, wide accommodation, analgesic rapid, effect is lasting, characteristics such as thorough treatment.
Claims (7)
1. Chinese medicine preparation for the treatment of flu, it is characterized in that: it is made by following parts by weight of traditional Chinese medicines:
Blank sheet of paper fan 12-22 part, Cortex schefflerae octophyllae 20-35 part, Radix Platycodonis 5-10 part, Herba Artemisiae Annuae 12-22 part, Radix Helicteris 6-12 part, Radix Isatidis 12-22 part, Radix Glycyrrhizae 3-8 part.
2. the Chinese medicine preparation of treatment flu according to claim 1 is characterized in that: it is granule, tablet, capsule, pill, oral liquid or pharmaceutically suitable dosage form.
3. the production method of the Chinese medicine preparation of a treatment as claimed in claim 1 flu, it is characterized in that: the technological process that granule is produced is as follows:
(1) claims medicine: blank sheet of paper fan 12-22 part, Cortex schefflerae octophyllae 20-35 part, Radix Platycodonis 5-10 part, Herba Artemisiae Annuae 12-22 part, Radix Helicteris 6-12 part, Radix Isatidis 12-22 part, Radix Glycyrrhizae 3-8 part;
(2) water extraction: in above Chinese medicine → the put Chinese medicine extraction jar → add 10-15 times of water → heated and boiled 1-2 hour → emit medicinal liquid → medicinal cupping and add 5-10 times of water gaging → reheating and boil 0.5-1 hour → medicinal liquid and emit filtration → medicinal liquid;
(3) medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating is concentrated into 2-3 times of medicine volume → cooling;
(4) ethanol precipitation: 95% ethanol to the concentration of alcohol of 3 times of amounts of medicinal liquid → add reach be put in after 60-70% → stirring 4-8 ℃ → leave standstill 12-24 hour → filter;
(5) reclaim ethanol: filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooled and filtered → medicinal liquid;
(6) medicinal liquid concentrates: and medicinal liquid → put is in the concentration pan → and relative density was the cream drug of 1.10-1.15 when heating concentrate → obtained 80 ℃;
(7) granulate: cream drug → with sucrose; the sucrose addition is by 2 times according to the gross weight of crude drug; can add ephedrine hydrochloride 0.1-0.2 part, ginger tincture 0.1-0.2 part; Oleum menthae 0.1-0.2 part; eucalyptus oil 0.1-0.2 part is mixed, and drying obtains medicated powder → granulator and granulates; then quantitatively → and encapsulation → finished product → packing, obtain the granule finished product.
4. the production method of the Chinese medicine preparation of a treatment as claimed in claim 1 flu, it is characterized in that: the technological process that capsule is produced is as follows:
(1) claims medicine: blank sheet of paper fan 12-22 weight portion, Cortex schefflerae octophyllae 20-35 weight portion, Radix Platycodonis 5-10 weight portion, Herba Artemisiae Annuae 12-22 weight portion, Radix Helicteris 6-12 weight portion, Radix Isatidis 12-22 weight portion, Radix Glycyrrhizae 3-8 weight portion;
(2) water extraction: in above Chinese medicine → the put Chinese medicine extraction jar → add 10-15 times of water gaging → heated and boiled 1-2 hour → emit medicinal liquid → filtration → medicinal residues and add 5-10 times of water gaging → add thermogravimetric and boil 0.5-1 hour → medicinal liquid and emit → filter → medicinal liquid;
(3) medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating concentrates → to 2-3 times of medicine volume → cooling;
(4) ethanol precipitation: above medicinal liquid → add 95% ethanol to concentration of alcohol reaches 60-70% → stir → put 4 ℃-8 ℃ to leave standstill 12-24 hour → filtration → filtrate;
(5) reclaim ethanol: above filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooling → filtration → medicinal liquid;
(6) medicinal liquid concentrates: and above filtrate → put is in the concentration pan → and relative density was the cream drug of 1.10-1.15 when heating concentrate → obtained 80 ℃;
(7) pharmacy powder: above cream drug → add adjuvant → powder process drying → obtain medicated powder;
Above-mentioned medicated powder also can add ephedrine hydrochloride 0.1-0.2 part, ginger tincture 0.1-0.2 part, Oleum menthae 0.1-0.2 part, and eucalyptus oil 0.1-0.2 part is mixed, and drying obtains medicated powder;
(8) glue capsule and sealed cans: glue capsule → tin seamer upper closure cans on above medicated powder and the appropriate amount of auxiliary materials mixing → capsule machine → obtain capsule finished product;
Above-described adjuvant is a magnesium stearate, or meets other adjuvant of international and national Specification, and it is 3-15% that adjuvant adds mass content.
5. the production method of the Chinese medicine preparation of a treatment as claimed in claim 1 flu, it is characterized in that: the technological process of tablet manufacturing is as follows:
(1) claims medicine: blank sheet of paper fan 12-22 weight portion, Cortex schefflerae octophyllae 20-35 weight portion, Radix Platycodonis 5-10 weight portion, Herba Artemisiae Annuae 12-22 weight portion, Radix Helicteris 6-12 weight portion, Radix Isatidis 12-22 weight portion, Radix Glycyrrhizae 3-8 weight portion;
(2) water extraction: in above Chinese medicine → the put Chinese medicine extraction jar → add 10-15 times of water gaging → heated and boiled 1-2 hour → emit medicinal liquid → filtration → medicinal residues and add 5-10 times of water gaging → add thermogravimetric and boil 0.5-1 hour → medicinal liquid and emit → filter → medicinal liquid;
(3) medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating concentrates → to 2-3 times of medicine volume → cooling;
(4) ethanol precipitation: above medicinal liquid → add 95% ethanol to concentration of alcohol reaches 60-70% → stir → put 4 ℃-8 ℃ to leave standstill 12-24 hour → filtration → filtrate;
(5) reclaim ethanol: above filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooling → filtration → medicinal liquid;
(6) medicinal liquid concentrates: and above filtrate → put is in the concentration pan → and relative density was the cream drug of 1.10-1.15 when heating concentrate → obtained 80 ℃;
Above-mentioned medicinal liquid also can add ephedrine hydrochloride 0.1-0.2 part, ginger tincture 0.1-0.2 part, Oleum menthae 0.1-0.2 part, and eucalyptus oil 0.1-0.2 part is mixed, and drying obtains medicated powder;
(7) with above-mentioned cream drug, add right amount of auxiliary materials, mixing is granulated, drying, tabletting, coating, packing promptly gets tablet;
Described adjuvant is the pharmaceutic adjuvant of various medical standard universals, comprises filler, disintegrating agent, lubricant etc., and filler is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants; Disintegrating agent is Sodium Tvlose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling; Lubricant is the pharmaceutic adjuvant of Polyethylene Glycol, magnesium stearate, Pulvis Talci and tool lubrication.Wherein the weight content of filler, disintegrating agent, lubricant is respectively 30-55%, 3-15%, 0.3%-0.6%.
6. the production method of the Chinese medicine preparation of a treatment as claimed in claim 1 flu, it is characterized in that: the technological process that pill is produced is as follows:
(1) claims medicine: blank sheet of paper fan 12-22 weight portion, Cortex schefflerae octophyllae 20-35 weight portion, Radix Platycodonis 5-10 weight portion, Herba Artemisiae Annuae 12-22 weight portion, Radix Helicteris 6-12 weight portion, Radix Isatidis 12-22 weight portion, Radix Glycyrrhizae 3-8 weight portion;
(2) water extraction: in above Chinese medicine → the put Chinese medicine extraction jar → add 10-15 times of water gaging → heated and boiled 1-2 hour → emit medicinal liquid → filtration → medicinal residues and add 5-10 times of water gaging → add thermogravimetric and boil 0.5-1 hour → medicinal liquid and emit → filter → medicinal liquid;
(3) medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating concentrates → to 2-3 times of medicine volume → cooling;
(4) ethanol precipitation: above medicinal liquid → add 95% ethanol to concentration of alcohol reaches 60-70% → stir → put 4 ℃-8 ℃ to leave standstill 12-24 hour → filtration → filtrate;
(5) reclaim ethanol: above filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooling → filtration → medicinal liquid;
(6) medicinal liquid concentrates: and above filtrate → put is in the concentration pan → and relative density was the cream drug of 1.10-1.15 when heating concentrate → obtained 80 ℃;
(7) with the above-mentioned cream drug that obtains, add right amount of auxiliary materials, mixing is done binding agent with water, Mel or water and Mel and is prepared into ball, and packing is promptly;
Above-mentioned tablet, pill can adopt the medicated powder that adds ephedrine hydrochloride 1-2 weight portion, ginger tincture 1-2 weight portion, Oleum menthae 1-2 weight portion, eucalyptus oil 1-2 weight portion, also can not add these materials.
7. the production method of the Chinese medicine preparation of a treatment as claimed in claim 1 flu, it is characterized in that: the technological process that oral liquid is produced is as follows:
(1) claims medicine: blank sheet of paper fan 12-22 weight portion, Cortex schefflerae octophyllae 20-35 weight portion, Radix Platycodonis 5-10 weight portion, Herba Artemisiae Annuae 12-22 weight portion, Radix Helicteris 6-12 weight portion, Radix Isatidis 12-22 weight portion, Radix Glycyrrhizae 3-8 weight portion;
(2) water extraction: in above Chinese medicine → the put Chinese medicine extraction jar → add 10-15 times of water gaging → heated and boiled 1-2 hour → emit medicinal liquid → filtration → medicinal residues and add 5-10 times of water gaging → add thermogravimetric and boil 0.5-1 hour → medicinal liquid and emit → filter → medicinal liquid;
(3) medicinal liquid concentrates: and medicinal liquid → put is in the concentration tank → and heating concentrates → to 2-3 times of medicine volume → cooling;
(4) ethanol precipitation: above medicinal liquid → add 95% ethanol to concentration of alcohol reaches 60-70% → stir → put 4 ℃-8 ℃ to leave standstill 12-24 hour → filtration → filtrate;
(5) reclaim ethanol: above filtrate → put is in the ethanol recycling can → heating recovery ethanol → medicinal liquid → cooling → filtration → medicinal liquid;
(6) medicinal liquid concentrates: and above filtrate → put is in the concentration pan → and relative density was the cream drug of 1.10-1.15 when heating concentrate → obtained 80 ℃;
(7) with the above-mentioned cream drug that obtains, the sucrose that adds 3 times of weight is mixed, adds 5-6 pure water doubly again, makes oral liquid;
Described oral liquid can also add ephedrine hydrochloride 0.1-0.2 part, ginger tincture 0.1-0.2 part, Oleum menthae 0.1-0.2 part, eucalyptus oil 0.1-0.2 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101246352A CN101181393A (en) | 2007-11-22 | 2007-11-22 | Chinese medicine preparation for curing common cold and producing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101246352A CN101181393A (en) | 2007-11-22 | 2007-11-22 | Chinese medicine preparation for curing common cold and producing method thereof |
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| CN101181393A true CN101181393A (en) | 2008-05-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2007101246352A Pending CN101181393A (en) | 2007-11-22 | 2007-11-22 | Chinese medicine preparation for curing common cold and producing method thereof |
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| CN105572071B (en) * | 2016-03-14 | 2019-03-01 | 华润三九医药股份有限公司 | The method and application of the extracting solution of Ganmaoling Granules are quickly detected using near infrared spectroscopy |
| CN106214863A (en) * | 2016-08-15 | 2016-12-14 | 于明霞 | A kind of Chinese medicine preparation treating chronic pharyngitis |
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