CN103202392A - Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds - Google Patents
Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds Download PDFInfo
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Abstract
The invention provides application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds. According to the invention, when the NCG and the VC are combined, the heat stress resisting ability of livestock (particularly sows) can be remarkably increased, so that the NCG and the VC produce a synergistic effect, can be widely popularized and applied in the field of animal husbandry and have good market effect and social effect.
Description
Technical field
The present invention relates to the livestock culturing field, be specifically related to NCG and the VC application in preparation anti-heat stress feed additive or feed.
Background technology
Feed addictive refers to a small amount of or micro substance that adds in Feed Manufacturing processing, use, in feed consumption seldom but effect significantly.Feed addictive comprises the additive of nutritive additive, medicine class additive and some promotion digestion or metabolism, it improves breeding performonce fo animals to strengthening the basal feed nutritive value, guarantees animal health, save feed cost, improving aspect such as livestock products quality has obvious effects.
(N-Carbamylglutamate, NCG), Chinese is the N-carbamylglutamic acid to the N-carbamylglutamic acid.In the past, NCG can significantly increase muscle as nutrition fortifier on the one hand and produce (containing) amount mainly in mankind's use, added in the product of the short muscle growth of body building; As medicine, be used for the treatment of some human orphan disease on the other hand: lack hyperammonemia and the rare genetic disease-maple syrup urine disease of neonate (Kalkan etc., 2009) that causes as the congenital N-acetylglutamat of neonate (NAG) synzyme.
Recent research shows that NCG can promote arginic endogenous synthetic.Arginine is the free radical scavenger (Jiang Zhen etc., 2000) of body, and arginine and oxygen molecule oxygen generate nitric oxide (NO) through nitric oxide synthetase (NOS) catalysis.NO is a kind of novel cell informational molecule, has hemangiectasis, suppresses platelet aggregation, suppresses cell proliferation, suppresses effects (Assumpcao etc., 2008) such as lipid peroxidation and the formation of glycosylation dead end product.An amount of NO can remove oxygen radical in the animal body, effect ((Beligni etc., 2002 of performance anti-oxidation stress; Huang etc., 2009).Therefore, NCG can improve multiparous animal nest litter size and birth weight, promotion young animal g and D by promoting arginine endogenous synthetic.
Heat stress refers to the summation of nonspecific physiological reaction that any requirement that the body in high ambient temperature proposes body thermal environment is done.Non-specific physiological reaction mainly shows as: respiratory movement is accelerated, and carbon dioxide is got rid of to be increased, respiratory alkalosis; Heart failure, encephalemia, pulmonary edema, anoxic etc.; The vivo oxidation metabolism increases, and peroxide increases, the film system injury; Metabolism is accelerated, hypoimmunity; The increase of urinating, ion is lost increase.Along with global warming, heat stress has become one of key factor of harm herding production.The animal that comprises pig tends to produce heat stress, and cause above-mentioned reaction easily and cause appetite to descend even sick, and then the influence growth.From different results of study, NCG adds in the sow daily ration can improve production performance really, and determines that after deliberation the suitableeest addition of NCG in the sow daily ration should be the 0.5kg/ ton, and the optimum interpolation time is antenatal January-wean.But NCG is as a kind of feed addictive commonly used, the anti-heat stress ability that it shows after adding in sow feed, and still do not have bibliographical information at present with the effect that vitamin C is used.
Summary of the invention
The objective of the invention is to overcome the defective of conventional feed anti-heat stress scarce capacity, the application in preparation anti-heat stress feed additive and feed of NCG and vitamin C is provided.
The present invention discovers that though use NCG and vitamin C to have the effect of anti-heat stress to a certain extent separately, the effect degree is limited, be difficult to further raising, yet, both are used it significantly improve in the effect aspect the anti-heat stress, show that both have synergy.Based on this, the invention provides the application in preparation anti-heat stress feed additive and feed of NCG and vitamin C.
Above-mentioned application, the preferred weight ratio of NCG and vitamin C is 1～2:1～2, more preferably 1:1.Content in feed is preferably 0.05～0.15%(w/w), is preferably 0.1%(w/w).
Above-mentioned feed and feed addictive are used for improving the anti-heat stress ability of domestic animal, include but not limited to pig, especially say sow.
Above-mentioned feed addictive can directly make an addition in the daily ration of domestic animal, also can add simultaneously with other feed addictives, but should be noted that the combination matching of various compositions when adding.
Above-mentioned feed addictive should can improve income and input ratio so to greatest extent to the time period interpolation between the cub wean before production.For example, sow should be preceding 1 month of production to adding feed addictive of the present invention between weaning period.
N-carbamylglutamic acid among the present invention is N-acetylglutamat (being NAG) analog, and can play a role as NAG in animal body participates in the body urea cycle, long half time, and metabolic stability has biological function widely.Studies show that, NCG can be used as the metabolic activation agent and participates in dihydropyrrol-5-carboxylic acid synzyme (P5CS) and carbamyl phosphate synthetase I(CPS-I) activation, promote the synthetic citrulling of glutamine or proline, and then the synthetic (Wu etc. of promotion arginine (Arg), 2004), also therefore be referred to as activator in the arginine.As the NAG analog, NCG makes the body arginine maintain higher physiological level, through being converted into the material of important biomolecule activity after a series of metabolic processes, mainly is nitric oxide (NO) and polyamines (comprising putrescine, spermidine and spermine).By above as can be known, arginine anti-oxidation stress effect in vivo mainly realizes by the NO approach.
Vitamin C among the present invention is as water-soluble free radical scavenger, the reaction that participates in is more than fat-soluble free radical scavenger vitamin E, as seen the mechanism of vitamin C removing free radical is also abundant than vitamin E, and vitamin C can also assist vitamin E and glutathione to remove free radical except the function of free radical is removed in direct performance.In the swine rearing standard (NY/T65-2004) ascorbic content in the sow feed do not had and explicitly call for.In recent years since, vitamin C is prevented and treated aspects such as infectious disease, poisoning and metabolic disease and is found broad application in the reproductive capacity, the anti-heat stress ability that improve pig, and has obtained significant effect (good fortune is established power, 2012).
The present invention makes an addition to NCG and vitamin C can reduce sow respiratory rate and body temperature under the hot conditions in the sow feed, the content of MDA and cortisol in the reduction blood, increased the content of immunoglobulin G and heat shock protein 70 in the blood, especially show the content that has extremely significantly reduced MDA and cortisol in the blood, reduce the generation of interior free yl, reduced the heat stress that high temperature produces sow.And the present invention studies show that, it is very limited only to use NCG or vitamin C to improve the anti-heat stress ability of domestic animal separately, but after both were combined, its anti-heat stress ability significantly improved, and shows that NCG and vitamin C have produced synergy.
The specific embodiment
Following examples are used for further specifying the present invention, but should not be construed as limitation of the present invention.Under the prerequisite that does not deviate from the present invention's spirit and essence, modification or replacement to the present invention does all belong to category of the present invention.
Embodiment 1
1. material
1.1 additive N-carbamylglutamic acid (purity 〉=97%), vitamin C (purity 〉=99%)
1.2 animal genealogy of law Da Bai sow (large-scale kind of pig farm, Beijing)
2. method and result
2.1 experimental design
Sow is tested 7～August in 2012 and carries out, and duration of test temperature on average is 25.8 degree, daily maximum temperature average out to 30.2 degree, and wherein to be higher than 30 ℃ fate be 47 days to daily maximum temperature; Medial humidity is 58.5%.
In the sow feeding experiment, choose 120 of the genealogy of law Da Bai sows of age, parity unanimity, be divided into 6 groups at random, 20 every group.Every group of a kind of processing of accepting between antenatal January-weaning period at random in the table 1, every group of additive addition that uses sees Table 1.After additive used 3 days the opening entry daily feed intake, at participate in the experiment respiratory rate and the body temperature of pig of 14 mensuration every day, every group of litter size of childbirth back record, product young number alive, nascent litter weight, 25 ages in days wean back record wean young number alive, weight of weaning litter, calculate average respiratory rate, body temperature, nascent average individual weight and the average individual weight that weans respectively, gather vena cava anterior blood early morning on the same day at Farrowing, measure MDA (MDA), immunoglobulin G (IgG), cortisol (Cor), heat shock protein 70 (HSP70) content behind the separation of serum.
Table 1 experimental design
2.2 result of the test
Add different additive between antenatal January-weaning period sow respiratory rate, body temperature and feed intake have all been produced influence (table 2).By table 2 as seen, add NCG, vitamin C or NCG in sow antenatal January-feed for weaned and ascorbic composition can reduce sow respiratory rate and body temperature, improve the feed intake of sow under the heat stress weather condition, especially obvious with the C group.
Table 2 different additive is to the influence of sow respiratory rate, body temperature and feed intake
Annotate: the different lowercase alphabet differentials of same row different significantly (p＜0.05).
Add different additive between antenatal January-weaning period sow production performance has all been produced influence (table 3).By table 3 as seen, add NCG, vitamin C or NCG in the feed between sow antenatal January-weaning period and its production performance of ascorbic composition all is better than control group, wherein obvious with C group effect, can obtain maximum wean young number alive and individual counterpoise when mainly showing wean.
Table 3 different additive is to the influence of sow production performance
Annotate: the different lowercase alphabet differentials of same row different significantly (p＜0.05), the different capitalizations of same row are represented difference extremely significantly (p＜0.01).
Add different additive between antenatal January-weaning period the sow anti-stress ability has all been produced influence (table 4).By table 4 as seen, add NCG, vitamin C or NCG in the feed between sow antenatal January-weaning period and its anti-stress ability of ascorbic composition makes moderate progress than control group, wherein obvious with C group effect, mainly show the content that reduces MDA and cortisol in the blood, increased the content of immunoglobulin G and heat shock protein 70 in the blood, especially show the content that has extremely significantly reduced MDA and cortisol in the blood, reduce the generation of interior free yl, reduced the heat stress that high temperature produces sow.
Table 4 different additive is to the influence of sow anti-stress ability
Annotate: the different lowercase alphabet differentials of same row different significantly (p＜0.05), the different capitalizations of same row are represented difference extremely significantly (p＜0.01).
Claims (10)
1.NCG and the application of vitamin C in preparation anti-heat stress feed additive or feed.
2. according to the described application of claim 1, it is characterized in that described NCG and ascorbic weight ratio are 1～2:1～2.
3. application according to claim 2 is characterized in that described NCG and ascorbic weight ratio are 1:1.
4. according to each described application of claim 1～3, it is characterized in that described NCG and the vitamin C content in feed is 0.05～0.15%(w/w).
5. application according to claim 4 is characterized in that, described NCG and the vitamin C content in feed is 0.1%(w/w).
6. anti-heat stress feed additive, it comprises NCG and the vitamin C of effective dose.
7. feed addictive according to claim 6 is characterized in that, described NCG and ascorbic weight ratio are 1～2:1～2.
8. feed addictive according to claim 6 is characterized in that described NCG and ascorbic weight ratio are 1:1.
9. contain the feed that each described heat resistanceheat resistant of claim 6～8 swashs feed addictive.
10. feed according to claim 9 is characterized in that, the content that described heat resistanceheat resistant swashs the feed addictive of property is 0.05～0.15%(w/w).
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| CN201310143179.1A CN103202392B (en) | 2013-04-23 | 2013-04-23 | Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds |
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Cited By (5)
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| CN103518981A (en) * | 2013-08-27 | 2014-01-22 | 镇江天和生物技术有限公司 | Feed premix for preventing and treating heat stress of sows |
| CN104323034A (en) * | 2014-11-12 | 2015-02-04 | 江苏农牧科技职业学院 | Feed capable of improving growth performance of broiler chicken as well as preparation method and application of feed |
| CN104431596A (en) * | 2014-12-18 | 2015-03-25 | 宁夏大学 | Daily ration capable of improving carcass quality of pen-fed sheep |
| CN104824377A (en) * | 2015-05-27 | 2015-08-12 | 北京市农林科学院 | Heat-stress-resistant breeding promotion composite additive for sows |
| CN106721067A (en) * | 2016-12-15 | 2017-05-31 | 宁夏大学 | A kind of anti-stress feed addictive and its application process |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103518981A (en) * | 2013-08-27 | 2014-01-22 | 镇江天和生物技术有限公司 | Feed premix for preventing and treating heat stress of sows |
| CN104323034A (en) * | 2014-11-12 | 2015-02-04 | 江苏农牧科技职业学院 | Feed capable of improving growth performance of broiler chicken as well as preparation method and application of feed |
| CN104323034B (en) * | 2014-11-12 | 2017-12-22 | 江苏农牧科技职业学院 | A kind of feed that can improve broiler growth performance and its production and use |
| CN104431596A (en) * | 2014-12-18 | 2015-03-25 | 宁夏大学 | Daily ration capable of improving carcass quality of pen-fed sheep |
| CN104824377A (en) * | 2015-05-27 | 2015-08-12 | 北京市农林科学院 | Heat-stress-resistant breeding promotion composite additive for sows |
| CN104824377B (en) * | 2015-05-27 | 2017-12-26 | 北京市农林科学院 | One broad sow anti-heat stress promotees breeding compound additive |
| CN106721067A (en) * | 2016-12-15 | 2017-05-31 | 宁夏大学 | A kind of anti-stress feed addictive and its application process |
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| CN103202392B (en) | 2014-11-12 |
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Inventor after: Zeng Shaopeng Inventor after: Liu Yan Inventor after: Bai Jiahua Inventor after: Xu Xiaoling Inventor after: Guo Yong Inventor after: Huang Zheng Inventor before: Feng Tao Inventor before: Liu Yan Inventor before: Bai Jiahua Inventor before: Xu Xiaoling Inventor before: Guo Yong Inventor before: Huang Zheng |
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Effective date of registration: 20160310 Address after: 528100, No. 48-6, Datang garden, Sanshui Industrial Zone, Foshan, Guangdong Patentee after: FOSHAN BOEN BIOTECHNOLOGY CO., LTD. Address before: 100097 Beijing, Haidian District Shuguang Garden Road, No. 9 Patentee before: Beijing Academy of Agriculture and Forestry Sciences |