CN103070295A - Feed additive for improving intestinal barrier function of livestock and poultry and application of feed additive - Google Patents
Feed additive for improving intestinal barrier function of livestock and poultry and application of feed additive Download PDFInfo
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- CN103070295A CN103070295A CN2013100373553A CN201310037355A CN103070295A CN 103070295 A CN103070295 A CN 103070295A CN 2013100373553 A CN2013100373553 A CN 2013100373553A CN 201310037355 A CN201310037355 A CN 201310037355A CN 103070295 A CN103070295 A CN 103070295A
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Abstract
The invention discloses a feed additive for improving an intestinal barrier function of livestock and poultry and an application of the feed additive. The additive is prepared by N-acetyl-L-glutamine and N-acetylcysteine at a mass ratio of (10-20):1. An application method comprises the steps that the additive with weight accounting for 0.05%-0.5% of the total weight of feed is directly added into the feed for the livestock and poultry or mixed with a carrier to form a premixed agent or mixed with other feed additives and feed raw materials to form a premix and a concentrate to feed the livestock and poultry. The additive has the outstanding advantages that the additive can facilitate development of intestinal mucosa effectively, and can improve the oxidation resistance and immune function of an intestinal tract and the intestinal barrier function. With the adoption of the additive, the incidence of intestinal tract diseases can be reduced, the health of the livestock and poultry can be facilitated, and the productivity can be improved.
Description
Technical field
The invention belongs to herding or field of feed, be specifically related to a kind of feed addictive of promoting the animal and bird intestines barrier function.
Background technology
Enteron aisle is not only the organ of digesting and assimilating of the interior maximum of livestock and poultry body, is the final absorption places of all nutriments, also is simultaneously immune organ maximum in the body.The development condition of enteron aisle and immunization barrier function thereof are most important with health to the growth of livestock and poultry.Children domestic animal in age, such as newborn piglet, enteron aisle is among the Rapid development, structure and function imperfection, digesting and assimilating with the immunization barrier function of nutrient has significant limitation.In addition, ablactation stress causes intestinal mucosa atrophy, gut epithelium integrality and gut barrier is destroyed and function of intestinal canal is disorderly.Improve the immunization barrier function of intestinal growth situation, maintenance and the enhancement enteron aisle of piglet in the production reality in the urgent need to adopting an effective measure.
The improvement of the reaching maturity of intestinal tissue, injury repair, structure and the maintenance of function need special nutrient and consume a large amount of nutrients, thereby nutrition is the most effective means of regulation and control intestinal growth and immunization barrier function.Some studies show that the N-acetyl-L-glutamine is the precursor substance of glutamine, can pass the animal intestinal barrier, generate glutamine and GABA behind enteron aisle catabolism.Glutamine participates in the metabolism of protein and sugar class, and cell repair is played an important role; GABA has the cellular metabolism of improvement, keeps the effect of cellular stress ability and reduction blood ammonia, improves function of intestinal canal.N-acetylcystein has stronger oxidation resistance, can promote the mucosal epithelium Growth and Differentiation, and mucosa structure is obviously improved, and safeguards gut barrier.N-acetyl-L-glutamine and N-acetylcystein are by different mechanisms regulating intestinal canal physiological function, therefore its composition can more effectively promote intestinal mucosa to grow, strengthen enteron aisle oxidation resistance and immunologic function than one matter, thereby promotes gut barrier function.
Add the additive to promote the animal and bird intestines barrier function in the feed, can improve growth of animals or poultry performance and the general level of the health, reduce the use of growth accelerator and medicine, for the sustainable health development of aquaculture lays the foundation.
Summary of the invention
The purpose of this invention is to provide a kind of feed addictive of promoting the animal and bird intestines barrier function.
The technical measures that the present invention adopts are as follows:
A kind of feed addictive of promoting the animal and bird intestines barrier function is characterized in that: this feed addictive is formulated in proportion with N-acetyl-L-glutamine and two kinds of materials of N-acetylcystein.
The mass ratio of N-acetyl-L-glutamine and N-acetylcystein is in the described feed addictive: 10～20:1.
The using method of the present invention's feed addictive is: addition is 0.05%～0.5% according to feed gross weight meter, directly this product is added in the animal and fowl fodder; Or this product and carrier be mixed and made into pre-mixing agent; Or be mixed and made into premix, the concentrate feed form livestock and poultry of feeding with other feed addictive or feedstuff.
Advantage of the present invention is: this additive can effectively promote intestinal mucosa to grow, strengthen enteron aisle oxidation resistance and immunologic function, thereby promotes gut barrier function.Use this additive can reduce the intestines problem incidence, promote livestock birds health and improve production performance.Compare with the antibiotics additive have have no side effect, drug residue free, pollution-free, the advantage that is of value to animal and human's class health.
The specific embodiment
Embodiment 1
With N-acetyl-L-glutamine and the in mass ratio 10:1 combination of two kinds of materials of N-acetylcystein, compound is mixed, obtain a kind of feed addictive of promoting the animal and bird intestines barrier function.
Carry out the weanling pig test with this additive.48 weanling pigs are divided into two groups, three repetitions of every component (hurdle), 8 on every hurdle.Piglet source, age in days, body weight approach, and sex is consistent.Two groups of basal diets are consistent, and test group is added 0.35% feed addictive of the present invention, and the blank group does not add feed addictive of the present invention.Raised 21 days.The results are shown in Table 1, table 2, table 3 and table 4.
Table 1 adds the additive of enhancement gut barrier function to the impact of weanling pig intestinal mucosa oxidation resistance
Annotate: the female different persons of colleague's shoulder marking-up represent significant difference (p＜0.05).Below roughly the same.
Table 2 adds the additive of enhancement gut barrier function to the impact of weanling pig small intestinal mucosa immunity-associated cell quantity
Table 3 adds the additive of enhancement gut barrier function to the impact of weanling pig intestinal villi height/crypts degree of depth
Table 4 adds the additive of enhancement gut barrier function to the impact of Growth Performance of Weaning Piglets
The result shows, uses feed addictive of the present invention, compares with the blank group, can significantly improve the Small Intestine of Piglets mucosa structure, promote the enteron aisle oxidation resistance, improves the Intestinal Mucosal Immunity cell quantity; The piglet daily gain improves 16.09%; The material anharmonic ratio reduces by 12.33%; Diarrhea rate reduces by 51.6%.
Embodiment 2
N-acetyl-L-glutamine and two kinds of materials of N-acetylcystein are made up in the 20:1 ratio, compound is mixed, obtain a kind of feed addictive of promoting the animal and bird intestines physiological function.
Carry out broiler feeding experiment with this additive.With 160 of a collection of Cobb meat chicks that hatches, be divided into 2 groups, 8 repetitions of every component (cage), 10 in every cage.Two groups of basal diets are consistent, and test group is added 0.1% feed addictive of the present invention, and the blank group does not add feed addictive of the present invention.Raised 42 days.The results are shown in Table 5, table 6, table 7.
Table 5 adds the Additive On Chickens intestinal mucosa oxidation resistance of enhancement gut barrier function and the impact of SlgA expression
The impact of the Additive On Chickens intestinal villi height of table 6 interpolation enhancement gut barrier function/crypts degree of depth
Table 7 adds the impact of the Additive On Chickens growth performance of promoting gut barrier function
Result of the test shows, uses feed addictive of the present invention, compares with the blank group, can significantly improve the small intestine of broiler chickens mucosa structure, improves mucous membrane SlgA expression, strengthens the mucous membrane oxidation resistance; Improving the broiler chicken daily gain improves 14.8%, expects that anharmonic ratio reduces by 10.6%.
Claims (2)
1. feed addictive of promoting the animal and bird intestines barrier function, it is characterized in that: this feed addictive is comprised of N-acetyl-L-glutamine and N-acetylcystein, and the mass ratio of N-acetyl-L-glutamine and N-acetylcystein is 10～20:1.
2. a kind of application of promoting the feed addictive of animal and bird intestines barrier function according to claim 1 is characterized in that: using method is that addition counts 0.05%～0.5% according to the feed gross weight, directly this product is added in the animal and fowl fodder; Or this product and carrier be mixed and made into pre-mixing agent; Or be mixed and made into premix or the concentrate feed form livestock and poultry of feeding with other feed addictive or feedstuff.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310037355.3A CN103070295B (en) | 2013-01-31 | 2013-01-31 | Feed additive for improving intestinal barrier function of livestock and poultry and application of feed additive |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310037355.3A CN103070295B (en) | 2013-01-31 | 2013-01-31 | Feed additive for improving intestinal barrier function of livestock and poultry and application of feed additive |
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| CN103070295A true CN103070295A (en) | 2013-05-01 |
| CN103070295B CN103070295B (en) | 2015-05-27 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398498A (en) * | 2014-12-04 | 2015-03-11 | 武汉轻工大学 | Application of N-acetyl-L-cysteine in preparing drug for treating or preventing porcine virus infection |
| CN106260590A (en) * | 2016-07-29 | 2017-01-04 | 湖南晶天科技实业有限公司 | Feed additive and feedstuff |
| CN107712353A (en) * | 2017-11-10 | 2018-02-23 | 王芳 | A kind of feed addictive for preventing diarrhea of pigs and preparation method and application |
| CN110169494A (en) * | 2019-07-04 | 2019-08-27 | 湖南师范大学 | It is a kind of adjust animal and bird intestines growth and development feed addictive and its application |
| CN110506853A (en) * | 2018-05-22 | 2019-11-29 | 广州英赛特生物技术有限公司 | Application of the N- glycyl glutamine in animal feed additive |
| CN113440505A (en) * | 2021-06-16 | 2021-09-28 | 东北农业大学 | Application of N-acetylcysteine in preparation of medicine for treating pig intestinal injury caused by glyphosate |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398498A (en) * | 2014-12-04 | 2015-03-11 | 武汉轻工大学 | Application of N-acetyl-L-cysteine in preparing drug for treating or preventing porcine virus infection |
| CN106260590A (en) * | 2016-07-29 | 2017-01-04 | 湖南晶天科技实业有限公司 | Feed additive and feedstuff |
| CN107712353A (en) * | 2017-11-10 | 2018-02-23 | 王芳 | A kind of feed addictive for preventing diarrhea of pigs and preparation method and application |
| CN110506853A (en) * | 2018-05-22 | 2019-11-29 | 广州英赛特生物技术有限公司 | Application of the N- glycyl glutamine in animal feed additive |
| CN110169494A (en) * | 2019-07-04 | 2019-08-27 | 湖南师范大学 | It is a kind of adjust animal and bird intestines growth and development feed addictive and its application |
| CN113440505A (en) * | 2021-06-16 | 2021-09-28 | 东北农业大学 | Application of N-acetylcysteine in preparation of medicine for treating pig intestinal injury caused by glyphosate |
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|---|---|
| CN103070295B (en) | 2015-05-27 |
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Address after: 430023 Wuhan, Hubei Evergreen Garden Road, No. 68 Patentee after: WUHAN POLYTECHNIC University Address before: 430023 Hubei Province, Wuhan City Central West Evergreen Garden 1 Patentee before: Wuhan Polytechnic University |
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Effective date of registration: 20171031 Address after: 518000 Guangdong province Shenzhen City Guangming Street No. 18 North Road, Jin Xinnong building photo Patentee after: SHENZHEN JINXINNONG TECHNOLOGY CO.,LTD. Address before: 430023 Wuhan, Hubei Evergreen Garden Road, No. 68 Patentee before: Wuhan Polytechnic University |