CN103083715A - Hydrogel scar patch for softening and fading scars - Google Patents
Hydrogel scar patch for softening and fading scars Download PDFInfo
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- CN103083715A CN103083715A CN2011103432272A CN201110343227A CN103083715A CN 103083715 A CN103083715 A CN 103083715A CN 2011103432272 A CN2011103432272 A CN 2011103432272A CN 201110343227 A CN201110343227 A CN 201110343227A CN 103083715 A CN103083715 A CN 103083715A
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- cicatrix
- scar
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- scars
- softening
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Abstract
The invention relates to a hydrogel scar patch for softening and fading scars. The invention is characterized in that: besides serving as a drug delivery platform, a gel plaster also can treat scars; it has good therapeutic effects on scars, can soften and fade scar tissues, and can flatten scars. The principle of the hydrogel scar patch is based on a gel plaster's hydrophilic matrix, which has the characteristics that: 1. the hydrophilic gel matrix has a high moisture content up to over 70%, can actively hydrate scar skin, and the hydration degree is high, thus being more conducive to softening and flattening of scars; and 2. the hydrophilic gel matrix generates mechanical compression on skin surfaces, thus exerting a mechanical pressure on scar bodies.
Description
Technical field
The present invention relates to a kind of various treating acnes that are applied to, hydrogel scar plaster take hydrogel as main component, the effect such as can play the cicatrix desalination, cicatrix is softening, cicatrix flattens also can play antipruritic, analgesic effect to cicatrix simultaneously.
Background technology
Cicatrix is the inevitable outcome after various wound healing, if but healing is not enough or healing is excessive, namely can produce cicatrix, if trace continues propagation, can become hypertrophic cicatrix.According to the various extent of injury that cause damage factor, and the body constitution of wounded body, can cause following a few class cicatrix: show shallow scars, atrophic cicatrix, depressed scar, hypertrophic cicatrix, keloid, the people of cicatrix body constitution particularly, cicatrix is especially obvious.Cicatrix can bring great inconvenience to the patient, and the hypertrophic cicatrix as burn causes can cause local pruritus, pain, and even dysfunction, seriously perplex the patient.And the control of cicatrix is a difficult problem of medical domain always, although in cicatrix, injection hormone effect is better, the early stage sufferings remission of cicatrix is not obvious, is not suitable for the control of large tracts of land cicatrix, and side effect is large, and the patient is difficult for accepting.
Silicon gel scar plaster is except invalid to the sufferings of cicatrix, various treating acnes are had reasonable therapeutic effect, can better soften cicatrix, make cicatrix flatten, fade, and side effect is little, and the mechanism of its Main Function is hydration, mechanical pressure and electrostatic field.studies show that, half of the too late normal skin of silicate gel film moisture-vapor transmission (Liu Wenge. the Li Sujuan chief editor. cicatrix prophylactic treatment [M]. Beijing: publish the learning centre, 2000:19.), because the moisture evaporation is restricted, keratodermatitis water retention phenomenon occurs, reduce the demand of blood capillary, thereby the hypertrophy that suppresses blood capillary, reduce the deposition of collagen, thereby reach the purpose of controlling scar hyperplasia (Li Huiyuan. blood vessel and bioactie agent thereof and scar hyperplasia [J]. the Chinese Clinical rehabilitation, 2002, 6 (20): 3080-3081.), the mechanism of hydration that Here it is.As for the mechanical pressure effect, there is the scholar to think, silicate gel film sticks and can produce the mechanical pressure that continues to skin, cause the local organization defective, reducing tissue metabolism leads, improve collagenase activity in wound, be reduced to fibrocyte content, enlarge intercellular substance, be beneficial to that the collagen bundle disperses and regular distribution (Nie Xue, a refined word, Xing Jinxia. silicate gel film adds the Elastic bandage use in conjunction and treats hypertrophic cicatrix [J]. the Chinese Clinical rehabilitation, 2005.9 (10): 1), and the collagen fiber confusion is one of key character of hypertrophic cicatrix.Also have document to think, silicon gel scar plaster has the effects such as the hypertrophy that suppresses cicatrix, softening cicatrix at the electrostatic field of cicatrix surface generation.
But above-mentioned silicon gel scar plaster, there are following problems: 1, a little less than hydration: at first, moisture-free in this series products, its hydration is to evaporate by moisture of skin to be subject to stopping of silicon gel-like product, the passive retention of moisture is in cicatrix skin, and hydration is limited; Secondly, because some damages are heavier, as III degree burn, the destructions such as sweat gland of skin, the moisture evaporation is limited, and hydration is weakened greatly; 2, drug combination difficulty: be difficult to combination in silicon gel scar plaster, comprise the composition that other has the inhibition cicatrix, drug combination improves curative effect.Utilize two-layer silicon gel glued membrane surrounding sealant sealing although mention in patent 03115384.4, middle lacuna medication stores adds medicine, and medicine can see through the silicate gel film surface that penetrates to the skin, and plays the purpose that administration increases curative effect.Although silicate gel film has certain ability that sees through steam, yet medicine or other are to the molecular weight of cicatrix effective ingredient tens times of hydrones normally, or hundred times, even therefore the silicon gel has the logical permeability of film medicine, also very limited, therefore, silicate gel film is not the ideal carrier of Transdermal absorption.
At first gel ointment is developed to a kind of ancient dosage form poultice transformation as far back as 20 century 70 Japan, be that a kind of water content is high, good biocompatibility, transdermal absorption formulation that content of dispersion is large, good to the pharmaceutical pack capacitive, said preparation is come from the Japanese transliteration, is again cataplasma.Pharmacopeia of Japan is defined as cataplasma and usually contains drug powder and derived essential oil, makes the mud shape or extend to be shaped, and is applied to the external preparation on wet cloth.2010 editions pharmacopeia are referred to as gel ointment (former title cataplasma), and it coats the emplastrum of making on back lining materials after being defined as and being extract, decoction pieces, chemicals and suitable hydrophilic matrix mixing.Substrate commonly used commonly used has sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel.Therefore, from essence, gel ointment is a kind of transmission platform of medicine, is a kind of externally applied transdermal absorption preparation.
Summary of the invention
The purpose of this invention is to provide a kind of gel ointment that utilizes as the purposes for the treatment of cicatrix.
We study discovery, and gel ointment is as the outer other purposes of drug delivery platform: the treatment cicatrix; It has good therapeutical effect to cicatrix, can soften, desalinate scar tissue, can be that cicatrix flattens.Its principle is based on the hydrophilic matrix of gel ointment, following characteristic: 1, the hydrophilic gel water content of substrate is high, can reach more than 70%, can be to cicatrix skin aquation initiatively, the degree of hydration is high, more is conducive to softening, flattening of cicatrix; 2, hydrophilic gel substrate produces mechanical pressure at skin surface, applies mechanical pressure can for the cicatrix body.
In fact, in various Chinese medicine and western medicine, have also that many compositions are synthetic to the collagen of cicatrix, fibroblast etc. has inhibitory action, current composition can pass through this drug delivery platform of gel ointment, acts on cicatrix, makes treating acne more effective.
The specific embodiment
Gel ointment is as the outer other purposes of drug delivery platform: the treatment cicatrix; It has good therapeutical effect to cicatrix, can soften, desalinate scar tissue, can be that cicatrix flattens.Its principle is based on the hydrophilic matrix of gel ointment, following characteristic: 1, the hydrophilic gel water content of substrate is high, can reach more than 70%, can be to cicatrix skin aquation initiatively, the degree of hydration is high, more is conducive to softening, flattening of cicatrix; 2, hydrophilic gel substrate produces mechanical pressure at skin surface, applies mechanical pressure can for the cicatrix body.
Experiment case study is analyzed:
This group 17 examples, male 6 examples, women's 9 examples, the age is in 10-65 year, course of disease January-4 year.Scar hyperplasia 8 examples after burn, scar hypertrophy 7 examples after operation, keloid 2 examples.Wherein 6 examples after surgery in January partial cut-out itch, twinge, hyperemia, slightly broadening of otch.
Using method:
First after the affected part is Irrigation, peel off the release paper of product, then toughness gel face is sticked on the dry cicatrix affected part of cleaning.Can change once in every 1-2 days.After the burn scar healing, contrafluxion is applied ointment or plaster immediately, the 3-12 month course for the treatment of.There are hyperemia, otch broadening, companion's sufferings in 2 weeks after suture removing as finding wound, can apply ointment or plaster, and the 3-6 month course for the treatment of, until cicatrix is softening, complexion changed is light, without obvious thorn sufferings.
Efficacy assessment standard:
Produce effects: the hypertrophy cicatrix obviously flattens, softens, color charcoal calmness goes down, the sufferings transference cure.Effectively: the scar hyperplasia degree is improved before, and pigmentation slightly has and goes down or the sufferings degree alleviates.Invalid: symptom does not disappear, and cicatrix still swells, and is secretly to take off color
Result:
This group 17 examples, produce effects: 7 examples (41%), effectively: 9 examples (53%), invalid: 1 example (6%), total effective rate are 94%.In clinical use procedure, have no adverse reaction and side effect.
Claims (1)
1. hydrogel is applied to scar plaster, it is characterized in that: gel ointment can also be treated cicatrix as the drug delivery platform is outer; It has good therapeutical effect to cicatrix, can soften, desalinate scar tissue, can be that cicatrix flattens, its principle is based on the hydrophilic matrix of gel ointment, following characteristic is arranged: 1, the hydrophilic gel water content of substrate is high, can reach more than 70%, can be to cicatrix skin active aquation, the degree of hydration is high, more is conducive to softening, flattening of cicatrix; 2, hydrophilic gel substrate produces mechanical pressure at skin surface, applies mechanical pressure can for the cicatrix body.
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CN2011103432272A CN103083715A (en) | 2011-11-03 | 2011-11-03 | Hydrogel scar patch for softening and fading scars |
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CN2011103432272A CN103083715A (en) | 2011-11-03 | 2011-11-03 | Hydrogel scar patch for softening and fading scars |
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CN2011103432272A Pending CN103083715A (en) | 2011-11-03 | 2011-11-03 | Hydrogel scar patch for softening and fading scars |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111282015A (en) * | 2020-02-14 | 2020-06-16 | 王阳 | Artificial skin scar removing plaster |
Citations (4)
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GB2425487A (en) * | 2005-04-26 | 2006-11-01 | Dow Corning | Wound dressing and method of preparation |
KR100847971B1 (en) * | 2006-08-24 | 2008-07-22 | 대화제약 주식회사 | A wound-healing dressing patch with hydrogel layer containing chitosan |
CN101524328A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Gel ointment for treating burn and scald |
CN101990544A (en) * | 2006-03-31 | 2011-03-23 | 利普泰股份公司 | Synthetic peptides used for treating the skin and use thereof in cosmetic or dermopharmaceutical compositions |
-
2011
- 2011-11-03 CN CN2011103432272A patent/CN103083715A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2425487A (en) * | 2005-04-26 | 2006-11-01 | Dow Corning | Wound dressing and method of preparation |
CN101990544A (en) * | 2006-03-31 | 2011-03-23 | 利普泰股份公司 | Synthetic peptides used for treating the skin and use thereof in cosmetic or dermopharmaceutical compositions |
KR100847971B1 (en) * | 2006-08-24 | 2008-07-22 | 대화제약 주식회사 | A wound-healing dressing patch with hydrogel layer containing chitosan |
CN101524328A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Gel ointment for treating burn and scald |
Non-Patent Citations (2)
Title |
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MICHAEL H.GOLD等: "Prevention of Hypertrophic Scars and Keloids by the Prophylactic Use of Topical Silicone Gel Sheets Following a Surgical Procedure in an Office Setting", 《DERMATOL SURG》, vol. 27, no. 7, 31 July 2001 (2001-07-31), pages 641 - 644 * |
易南等: "烧伤后增生性瘢痕和瘢痕挛缩的康复处理", 《中国康复理论与实践》, vol. 13, no. 10, 31 October 2007 (2007-10-31), pages 949 - 3 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111282015A (en) * | 2020-02-14 | 2020-06-16 | 王阳 | Artificial skin scar removing plaster |
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Application publication date: 20130508 |