CN100584375C - Formula for treating scar - Google Patents
Formula for treating scar Download PDFInfo
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- CN100584375C CN100584375C CN200510107283A CN200510107283A CN100584375C CN 100584375 C CN100584375 C CN 100584375C CN 200510107283 A CN200510107283 A CN 200510107283A CN 200510107283 A CN200510107283 A CN 200510107283A CN 100584375 C CN100584375 C CN 100584375C
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- hyaluronidase
- preparation
- cicatrix
- treatment
- skin
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A medicine for treating scar is composed of three components which are mixed before it is applied. It is proportionally prepared from hyaluronidase, lactose, azoanthracene, purified water, triamcinolone, refined lavenda oil, and ethyoxylated hydrogenated lanolin.
Description
Technical field
The invention belongs to the pharmaceutical preparation of medical field treatment cicatrix, relate in particular to and use a kind ofly, be equipped with the formed pharmaceutical preparation of auxiliary agent by biological product hyaluronidase, Garden lavender quintessence oil, Triamcinolone Acetonide compatibility.Have the sugar of influence and protein metabolism, strengthen gluconeogenesis, impel protein to decompose, metabolism strengthens, disturb the mechanism of fibroplasia, people's skin is hindered the keloid of fibrin hyperplasia that face causes and the formed local eminence of collagen fiber over-deposit, hard, color flushing, the sense of tool sufferings because of operation, burn, scald and accidental injury, thin out red, the therapeutical effect of removing the sufferings sense of flat, softening, color is arranged again.
The mechanism of cicatrization mainly is the over-deposit of fibrin hyperplasia and collagen fiber and forming.Because collagen is synthetic and the imbalance of degraded, the appearance of unusual mucopolysaccharide, and the propagation of muscle fiber cell causes local eminence, hard, color flushing, sufferings.It organizes particularly compact tough and tensile, and the clothes compressing also can cause the sufferings symptom.If scratching and can further promote, patient the hypertrophy of cicatrix causes vicious cycle.
The formation of cicatrix is to lack protection etc. because wound surface lacks the skin of regulatory mechanism and healing in agglutination, thereby causes the generation of cicatrix.The important pathological change of hypertrophy cicatrix is blood vessel, collagen fiber hypertrophy, arrangement disorder, and very itching of skin is in the scar tissue due to wall of micrangium and the peripheral termination of nerve anoxia thereof, rather than the teleneuron irriate of skin surface causes.
At present, the method for treatment cicatrix is commonly used have surgery alone excision, freezing or laser therapy, Triamcinolone Acetonide part,
90Ointment or ointment that strontium is applied ointment or plaster treatment, operation or the deep x ray radiotherapy of electron ion postoperative and contained Triamcinolone Acetonide are smeared.As a result, surgery alone excision, freezing or laser therapy, 100% recurrence.What have also causes skin lesion, or local pain, and curative effect is undesirable.Simple with the Triamcinolone Acetonide local injection or contain Triamcinolone Acetonide ointment or ointment is smeared, can only be the disease controlling development, mitigation symptoms is difficult for fully recovering.
90Strontium is applied ointment or plaster the treatment effective percentage less than 40%, and operation or the radiotherapy of electron ion postoperative deep x ray are though the effective percentage height brings in various degree injury to human body.Simultaneously, to privileged sites such as thymus, do not give birth near patient's the reproductive system and the child can not use.Otherwise, will have serious consequences.
Summary of the invention
The purpose of this invention is to overcome the deficiencies in the prior art, and employing modern medical theory and clinical summary, can influence sugar and protein metabolism in extensive screening, strengthen gluconeogenesis, impel protein to decompose, metabolism strengthens, disturb on the basis of fibroplasia mechanism, and provide a kind of according to biological product hyaluronidase and Triamcinolone Acetonide compatibility, carry the pharmaceutical preparation of penetrating agent Ah assistant's anthracene and auxiliary agent, to people's skin because of operation, burn, fibrin hyperplasia and the formed local eminence of collagen fiber over-deposit that face causes hindered in scald and accidental injury, hard, the keloid of color flushing tool sufferings sense has again flat, softening, color is thin out red, remove the effect of sufferings sense, make it reach economical and practical, safe and efficient, easy to use purpose.
The object of the present invention is achieved like this, mixed by at least a biological product hyaluronidase, a kind of glucocorticoid Triamcinolone Acetonide and a kind of Chinese herbal medicine extract Garden lavender quintessence oil and auxiliary material.Its preparation umber is: hyaluronidase 1000
1U, lactose 600mg, Ah assistant's anthracene 100mg, pure water 10mil, Triamcinolone Acetonide 1000mg, Garden lavender quintessence oil 2000mg, Ah assistant's anthracene 100mg, ethoxylation hydrogenated lanolin 20g make A, B, C preparation respectively.
Compare with existing similar technology, the invention has following good effect:
1 the present invention is from the deficiency of present treatment cicatrix common method, it is first-selected selecting hyaluronidase for use, be because hyaluronidase extensively is present in the acid mucopolysaccharides macromolecular substances in people and the animal connective tissue, bring into play water conservation in vivo, osmotic pressure is regulated, keep tissue morphology, lubricated, mechanical function and important physical functions such as the gentle blow stress of diffusion barrier.Treat recovery from illness after a year, follow up a case by regular visits to after 2 years and do not see recurrent cases.
Its mechanism is to contain a large amount of carboxyls and hydroxyl in the hyaluronidase molecule, forms intramolecularly and intermolecular hydrogen bonding in aqueous solution.This makes it have powerful water retention, can be in conjunction with more than 1000 times water itself; Simultaneously, when higher concentration,, have significant viscoelasticity again, play the effect of softening cicatrix because its intermolecular interaction forms three grades of complicated network structure.
Hyaluronidase is the main component that constitutes extracellular matrix and intercellular substance, thereby participates in the regulation and control of cell internal and external exchange directly, the filter effect of performance physics and molecular information.Secondly the physiological function of hyaluronidase is different because of the molecular weight size.Macromolecule hyaluronidase pair cell moves, propagation, and differentiation and phagocytic function have inhibitory action, and the hyaluronidase of small-molecular weight then has facilitation.And the good affinity that utilizes itself and human body strengthens the therapeutic effect of medicine as carrier.
Hyaluronidase has the promotion healing, inflammation is had the effect that suppresses and prevent adhesion wound, for overcoming the limitation that natural hyaluronidase is easy to degrade at human body, it is carried out compound compatibility, carry Triamcinolone Acetonide, Ah assistant's anthracene, hyaluronidase behind the compatibility can design administration time as required, strengthen the therapeutic effect of medicine, direct regulation and control, directed regularly administration.Can also utilize the acceptor selection of hyaluronidase, the medicine location is discharged.Can fully recover with its treatment cicatrix, be difficult for recurrence.
But,, promptly lose activity rapidly under the room temperature because its character is extremely unstable.Its aqueous solution is preserved during at 0 ℃ more stable in (PH4.0～7.6).So, must take special measure could guarantee its activity.Get a desired effect, ensure that the method for hyaluronidase activity will be the key point of success or not.The present invention adopts full pressed powder that hyaluronidase is made solid preparation, faces with before being dissolved in the special solvent, has both avoided hyaluronidase also to overcome the loss of activity that hyaluronidase causes because of being heated in the unstability in the aqueous solution in the preparation process.
The Triamcinolone Acetonide tool influences sugar and protein metabolism, strengthens gluconeogenesis, impels protein to decompose, and metabolism strengthens, and disturbs the mechanism of fibroplasia, and the synthetic effect of the fine microcell DNA of the cicatrix of inhibition is arranged.That the keloid that people's skin is hindered fibrin hyperplasia that face causes and the formed local eminence of collagen fiber over-deposit, hard, color flushing, the sense of tool sufferings because of operation, burn, scald and accidental injury has again is flat, softening, thin out red, the effect of removing the sufferings sense of color.
Garden lavender quintessence oil tool heals a wound, the function of fatigue alleviating.More the scar effect of Garden lavender is derived from the characteristic of its activating cell, because it can promote cell regeneration, the secretion of balance skin oil and fat can accelerate to secrete the growth of the one-tenth fiber stem cell of collagen protein, so for the scar of skin good healing effect is arranged.
Ah assistant's anthracene is a penetrating agent, can accelerate the speed of medicine transdermal and non-stimulated to skin.Be characterized in all having better short running to use to many hydrophilic, lipophilic medicines.Its mechanism is that keratodermatitis cell membrane bits are increased, and biolipid plasma membrane discontinuity is increased, and lipoids produces irregular arrangement and dissolves the purpose that the skin lipoids reaches increases drug absorption in the keratodermatitis by making.Its skin penetration effect to medicine is quite strong.Medicine absorbs through skin owing to have the first pass effect of hepar of avoiding, but constant speed release medicine and reduce distinct advantages such as adverse effect, and the TTS of Ah assistant's anthracene (through transdermal therapeutic system) is stronger to the Triamcinolone Acetonide effect.
2. harmless to skin, local painless.Select hyaluronidase, Triamcinolone Acetonide, additive compatibility for use, to the skin avirulence, non-corrosiveness, nonirritant can not cause skin lesion and local pain.
3. be applicable to each position of whole body, easy to use.
4. use said preparation treatment recovery from illness after a year, follow up a case by regular visits to after 2 years and do not see recurrent cases.
The specific embodiment
＜one 〉, embodiment, make A, B, C preparation respectively:
A preparation: hyaluronidase 10001U
Lactose 600mg
Make tablet
B preparation: Ah assistant's anthracene 100mg
Pure water 10mil
Make the suspendible special solvent
C preparation: Triamcinolone Acetonide 1000mg
Garden lavender quintessence oil 2000mg
Ah assistant's anthracene 100mg
Ethoxylation hydrogenated lanolin 20g
Make emulsifiable paste
＜two 〉, test period: on June 9th, 2003
＜three 〉, the clinical data EXPERIMENTAL DESIGN: select outpatient service keloid patient 87 examples, wherein, male 50 examples, women 37 examples, the age was at 12 years old～60 years old.Skin lesion area diameter≤1cm40 example, 1cm～5cm25 example, 6cm～15cm22 example.Site of pathological change: women's head-ornaments portion 20 examples, trunk 25 examples, extremity 12 examples, abdominal part 30 examples, the course of disease 1 month-12 years.Be divided into 1 treatment group and 2 matched groups at random;
1 group of 44 example is said preparation treatment group.
2 group of 43 example is matched group, and simple the employing removes to pacify relaxed and comfortable injection, partial closure's treatment of injection in every month.
Concrete grammar: the 1st group of patient uses said preparation
Earlier the A preparation is dissolved in treat in the B preparation to dissolve fully after, solution directly is applied to the cicatrix wound surface, then, use manual massage, usefulness refers to that the strength of abdomen, palm pushes repeatedly at the coating place and rotate poking meridian method.Massage or push more than 15 minutes after each medication.Then, again the C preparation is coated with sub-cicatrix wound surface, uses manual massage, with referring to that the strength of abdomen, palm pushes and rotate and knead repeatedly at the coating place.Massage or push more than 15 minutes after each medication, be administered once every day, and consumption is decided on the cicatrix area.
The simple employing of matched group patient removes to pacify relaxed and comfortable injection, partial closure's treatment of injection in every month, and consumption is a foundation with the cicatrix size, adds during injection to use lignocaine, amount ratio is 1: 3.Select for use common 2ml syringe to extract medicinal liquid, the patient sets position, routine disinfection skin, and injection needle is parallel thrusting in the keloid in the cicatrix edge, and suitably pressurization injection medicinal liquid to cicatrix color bleaches.Pathological changes area the greater can adopt limit inserting needle marginal not to penetrate, and limit withdraw of the needle marginal not is penetrated and many injection points multi-method injection, till being bonded to whole cicatrix and bleaching with point, face.Partial closure's therapy is implemented by the treatment doctor, and first massage is carried out under physician guidance, after massage voluntarily.3 months is a course of treatment, treats after 6 months, 9 months, 1 year and observes localized variation, judges clinical efficacy, follows up a case by regular visits to after 9 days June in 2005 again.
＜four 〉, curative effect determinate standard (1) recovery from illness: the cicatrix softness, calm down, basic the same with normal skin, the cicatrix pain transference cure of itching, the diseased region functional rehabilitation no longer recurs after the treatment; (2) take a turn for the better: skin lesion flat soft, cicatrix is slightly swelled, thicken, little pain of itching; (3) invalid: cicatrix is still swelled, and thickens, and still has the pain symptom of itching.
＜five 〉, result: see the following form
Show in the table that treatment group cure rate is 95%, the matched group cure rate is 40%, learns by statistics and handles (X
2Check), two groups have highly significant difference, and utmost point significance meaning is arranged; Treatment group effective percentage is 100%, and the matched group effective percentage is 65%, learns by statistics and handles (X
2Check), two groups have highly significant difference, and utmost point significance meaning is arranged.
On June 9th, 2005 followed up a case by regular visits to later on, treatment group recovery from illness and take a turn for the better do not see recurrent cases, the matched group 15 example recurrences in 17 examples of fully recovering, 8 example recurrences in 11 examples that take a turn for the better.
Claims (1)
1, a kind of novel formulation for the treatment of acne is characterized in that: by hyaluronidase 1000
10, lactose 600mg, make the A preparation; By Ah assistant's anthracene 100mg, pure water 10mil, make the B preparation; Triamcinolone Acetonide 1000mg, Garden lavender quintessence oil 2000mg, Ah assistant's anthracene 100mg, ethoxylation hydrogenated lanolin 20g make the C preparation.A, B, C preparation are used simultaneously, are used for the treatment of cicatrix.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510107283A CN100584375C (en) | 2005-12-16 | 2005-12-16 | Formula for treating scar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510107283A CN100584375C (en) | 2005-12-16 | 2005-12-16 | Formula for treating scar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1981865A CN1981865A (en) | 2007-06-20 |
| CN100584375C true CN100584375C (en) | 2010-01-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200510107283A Expired - Fee Related CN100584375C (en) | 2005-12-16 | 2005-12-16 | Formula for treating scar |
Country Status (1)
| Country | Link |
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| CN (1) | CN100584375C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079809A (en) * | 2015-07-09 | 2015-11-25 | 广州赛莱拉干细胞科技股份有限公司 | Composition, preparation, method for preparing same, application and method for applying preparation |
| CN110123819B (en) * | 2019-06-03 | 2022-03-15 | 南阳南石医院 | Medicine and device for treating scars |
-
2005
- 2005-12-16 CN CN200510107283A patent/CN100584375C/en not_active Expired - Fee Related
Non-Patent Citations (6)
| Title |
|---|
| 消除瘢痕的药物研究. 陈浩宏等.现代中西医结合杂志，第12卷第11期. 2003 |
| 消除瘢痕的药物研究. 陈浩宏等.现代中西医结合杂志，第12卷第11期. 2003 * |
| 瘢痕疙瘩的治疗进展. 秦鸿志等.现代医药卫生，第20卷第19期. 2004 |
| 瘢痕疙瘩的治疗进展. 秦鸿志等.现代医药卫生，第20卷第19期. 2004 * |
| 薰衣草在新疆的研究现状及对策. 陈和平等.农垦医学，第27卷第5期. 2005 |
| 薰衣草在新疆的研究现状及对策. 陈和平等.农垦医学，第27卷第5期. 2005 * |
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| Publication number | Publication date |
|---|---|
| CN1981865A (en) | 2007-06-20 |
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Granted publication date: 20100127 Termination date: 20171216 |