CN103071143B - Traditional Chinese medicinal composition for treating senile dementia - Google Patents
Traditional Chinese medicinal composition for treating senile dementia Download PDFInfo
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- CN103071143B CN103071143B CN201310064678.1A CN201310064678A CN103071143B CN 103071143 B CN103071143 B CN 103071143B CN 201310064678 A CN201310064678 A CN 201310064678A CN 103071143 B CN103071143 B CN 103071143B
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating senile dementia. The traditional Chinese medicinal composition consists of the following ingredients according to a certain weight ratio: radix salviae miltiorrhizae, rhizoma corydalis, red paeony roots, tribulus terrestris, fingered citron, fructus citri, ligusticum wallichii, safflower, musk, spina gleditsiae, radix angelicae sinensis, astragali radix, albizia flower, licorice roots northwest origin, ginger and fructus ziziphi Jujubae, has the effects of promoting blood circulation to remove blood stasis, nourishing the heart to tranquilize mind, soothing liver-qi stagnation and removing dampness to reduce phlegm, and can be effectively used for curing the senile dementia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of senile dementia.
Background technology
Senile dementia, claim again Alzheimer, it is a kind of PDCD that occurs in Senectitude and presenium, refer to a kind of persistence higher nerve functional activity obstacle, there is no under the state of disturbance of consciousness the obstacle of the aspects such as memory, thinking, analysis judgement, visual space identification, emotion.Its main pathological characters is in brain, occur a large amount of senile plaques, neurofibrillary tangles, amyloid beta deposition and neuron vacuolar degeneration and lose in a large number.Along with the aging of social population, senile dementia sickness rate rises relatively, and the dementia prevalence of over-65s is 5%～10% at present, and still among increasing.In TCM Document, there is no this name of disease of alzheimer disease, but have a large amount of discussions to sporadically appear in the cards such as " forgetful ", " god is slow-witted ", " dementia ", " strongly fragrant disease ", " literary composition is silly ", " dementia ".Its main pathogenesis can be summarized as " empty, strongly fragrant, expectorant, the stasis of blood ", and the virtual loss of brains and the five internal organs of take is this, and take strongly fragrant, expectorant, the stasis of blood is mark.Senile dementia is the disease of deficiency in origin and excess in superficiality.Deficiency in origin is that declining of negative and positive of qi and blood is few, and mark mostly is the accumulation of the pathological products such as gas, fire, expectorant, the stasis of blood actually.Though its sick position is at brain, closely related with the function of the internal organs such as conscience spleen kidney.Treatment by Chinese herbs is dialectical ties heavy curtain mutually with differential diagnosis of diseases, or controls from void opinion, or eliminating evil be main, or reinforcing and reducing concurrently.Facts have proved, Chinese medicine is of great significance treatment primary disease and prognosis tool, has potential advantage and wide DEVELOPMENT PROSPECT.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has good effect for treatment senile dementia, and target spot is many, the feature that side effect is little.
The present invention selects Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Radix Paeoniae Rubra, Fructus Atriplicis Sibiricae, Fructus Citri Sarcodactylis, Fructus Citri, Rhizoma Chuanxiong, Flos Carthami, Moschus, Spina Gleditsiae, Radix Angelicae Sinensis, Radix Astragali, Flos Albiziae, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae to combine, make each efficacy of drugs produce synergism these drug regimens, make it to there is blood circulation promoting and blood stasis dispelling, tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of drying dampness to eliminate phlegm, thus senile dementia can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor are bitter, are slightly cold.Enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Rhizoma Corydalis: be the tuber of papaveraceae plant corydalis.Nature and flavor are bitter, pungent, temperature.Return liver, the heart, stomach warp.Effect: promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Rhizoma Corydalis has hypnosis, calm and stable effect to central nervous system, and ethanol extract has remarkable expansion coronary vasodilator, reduces coronary resistance and the effect that increases blood flow.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor acid, bitter, cool.Enter liver, spleen channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.Radix Paeoniae water-ol extract has remarkable sedation.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, loose clot, only stomachache, moves back heat in blood, attacks carbuncle skin ulcer, controls mange.
Fructus Atriplicis Sibiricae: for zygophyllaceae is annual or the mature fruit of herbaceos perennial Fructus Tribuli Tribulus ter-restris L..Nature and flavor are bitter, pungent, flat.Enter Liver Channel.Effect: suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.
Fructus Citri Sarcodactylis: be the dry fruit of rutaceae Fructus Citri Sarcodactylis Citrus medica L. var. sarcodactylis Swingle.Nature and flavor are pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Effect: liver-smoothing, qi-regulating, and stomach and alleviating pain, dispersing the stagnated live-QI to relieve the stagnation of QI, drying dampness to eliminate phlegm.
Fructus Citri: be the dry mature fruit of rutaceae citron Citrus medica L. or fragrant circle Citrus wilsonii Tanaka.Nature and flavor are pungent, bitter, sour, temperature.Return liver, lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, expectorant falls in relieving distension.Contained volatile oil has gentle stimulation to gastrointestinal tract, can promote to wriggle and digestive juice secretion in the intestines and stomach, gets rid of enteral pneumatosis, and has phlegm-dispelling functions.< < Bencao Shiyi > >: degas, except mind expectorant water.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor are pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Rhizoma Chuanxiong has obvious sedation to central nervous system.Activity to animal brain when Rhizoma Chuanxiong volatile oil is a small amount of is inhibited, and medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter are had to excitation.
Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor are pungent, warm.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time.Carthamus yellow has the central inhibitory action of obvious enhancing barbital and chloral hydrate.< < Amplification on Materia Medica addendum > >: Flos Carthami, broken stagnant blood, nourishes blood.Multiplex removing blood stasis is few with nourishing blood.
Moschus: be the dry secretions in animal in deer family woods Moschus moschiferous Moschus berezovskii Flerov, horse Moschus moschiferous Moschus sifanicus Przewalski or the ripe male body note capsule of former Moschus moschiferous Moschus moschiferus Linnaeus.Nature and flavor are pungent, temperature, GUIXIN, spleen channel.Effect: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, pain relieving.Moschus or muscone have refreshment effect to central nervous system.
Spina Gleditsiae: be the Spina jujubae of leguminous plant Fructus Gleditsia.Acrid in the mouth, warm in nature.Return lung, Liver Channel.There is promoting blood circulation by removing wind, the effect of detumescence and apocenosis.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia to central nervous system.
Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Flos Albiziae: be the dry inflorescence of leguminous plant Herba Albiziae Albizia julibrissin Durazz..Nature and flavor are sweet, flat.GUIXIN, Liver Channel.Effect: Shu Yu, regulate the flow of vital energy, calm the nerves, active, nourish blood, YIN nourishing kidney, improving eyesight clears away heart-fire.
Radix Glycyrrhizae: be glycyrrhizic legume Glycyrrhiza uralensis Fisch., the dry root and rhizome of Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.< < Japan hanako materia medica > >: peace soul is determined soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Rhizoma Zingiberis Recens: be the fresh rhizome of zingiber Zingiber officinale Rosc..Nature and flavor are pungent, tepor.Return lung, spleen, stomach warp.Effect: relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough.
Fructus Jujubae: be the dry mature fruit of Rhamnaceae plant Fructus Jujubae Ziziphus jujuba Mill..Nature and flavor are sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.The two glucoside A of flavone in Fructus Jujubae have calmness, syngignoscism.< < herbal classic > >: " main trusted subordinate's pathogen, regulating the spleen and stomach is supported spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines."
Medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope: Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Corydalis 15-25 part, Radix Paeoniae Rubra 10-20 part, Fructus Atriplicis Sibiricae 15-25 part, Fructus Citri Sarcodactylis 10-20 part, Fructus Citri 10-20 part, Rhizoma Chuanxiong 7-17 part, Flos Carthami 5-15 part, Moschus 0.03-0.07 part, Spina Gleditsiae 20-28 part, Radix Angelicae Sinensis 13-23 part, Radix Astragali 25-35 part, Flos Albiziae 10-20 part, Radix Glycyrrhizae 3-9 part, Rhizoma Zingiberis Recens 6-12 part, Fructus Jujubae 3-7 part.
Wherein be preferably: 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Rhizoma Corydalis, 15 parts of Radix Paeoniae Rubra, 20 parts of Fructus Atriplicis Sibiricaees, 15 parts of Fructus Citri Sarcodactylis, 15 parts of Fructus Citris, 12 parts of Rhizoma Chuanxiongs, 10 parts, Flos Carthami, 0.05 part, Moschus, 24 parts of Spina Gleditsiaes, 18 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, 15 parts of Flos Albiziaes, 6 parts of Radix Glycyrrhizae, 9 parts, Rhizoma Zingiberis Recens, 5 parts, Fructus Jujubae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made to powder takes after mixing it with water; Can use decocting, obtain after filtration filtrate, add antiseptic to make oral liquid; Also can directly take if desired decoction (Moschus boiled water is taken after mixing it with water).
Medicine of the present invention has blood circulation promoting and blood stasis dispelling, tranquilizing by nourishing the heart, dispersing the stagnated live-QI to relieve the stagnation of QI, the effects such as drying dampness to eliminate phlegm, and good effect, target spot is many, and side effect is little, according to clinical 50 routine patients are observed to statistics, use 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 92%.
The specific embodiment
Embodiment mono-, 25 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Corydalis, 10 parts of Radix Paeoniae Rubra, 15 parts of Fructus Atriplicis Sibiricaees, 10 parts of Fructus Citri Sarcodactylis, 10 parts of Fructus Citris, 7 parts of Rhizoma Chuanxiongs, 5 parts, Flos Carthami, 0.03 part, Moschus, 20 parts of Spina Gleditsiaes, 13 parts of Radix Angelicae Sinensis, 25 parts of Radix Astragali, 10 parts of Flos Albiziaes, 3 parts of Radix Glycyrrhizae, 6 parts, Rhizoma Zingiberis Recens, 3 parts, Fructus Jujubae.
Embodiment bis-, 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Rhizoma Corydalis, 15 parts of Radix Paeoniae Rubra, 20 parts of Fructus Atriplicis Sibiricaees, 15 parts of Fructus Citri Sarcodactylis, 15 parts of Fructus Citris, 12 parts of Rhizoma Chuanxiongs, 10 parts, Flos Carthami, 0.05 part, Moschus, 24 parts of Spina Gleditsiaes, 18 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, 15 parts of Flos Albiziaes, 6 parts of Radix Glycyrrhizae, 9 parts, Rhizoma Zingiberis Recens, 5 parts, Fructus Jujubae.
Embodiment tri-, 35 parts of Radix Salviae Miltiorrhizaes, 25 parts of Rhizoma Corydalis, 20 parts of Radix Paeoniae Rubra, 25 parts of Fructus Atriplicis Sibiricaees, 20 parts of Fructus Citri Sarcodactylis, 20 parts of Fructus Citris, 17 parts of Rhizoma Chuanxiongs, 15 parts, Flos Carthami, 0.07 part, Moschus, 28 parts of Spina Gleditsiaes, 23 parts of Radix Angelicae Sinensis, 35 parts of Radix Astragali, 20 parts of Flos Albiziaes, 9 parts of Radix Glycyrrhizae, 12 parts, Rhizoma Zingiberis Recens, 7 parts, Fructus Jujubae.
The clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept patient's totally 50 examples for medical treatment, male's 42 examples wherein, women's 8 examples, M-F 5:1,72 years old mean age.
Two, diagnostic criteria:
1, with hypomnesis, the ability of remembering nearly thing and thing far away weakens, judge that cognitive personage, article, time, place ability go down, computing power goes down with the ability of identification locus structure, and understand others' language and the ability obstacle of answering a question systematically etc. is primary symptom.Sex-linkage feelings are unsociable and eccentric, apathetic expression, and language repeats, selfish narrow, obstinate stubborn, or groundless ground is glad, is easy to excitement or rage.Its abstract thinking ability declines, and can not explain or distinguish identical point and the difference of word, and moral ethics lacks, shameless, and character trait changes.
2, onset concealment, slower development, progressive increasing the weight of, the course of disease is generally longer.But also there is the morbidity of minority case more anxious.Patient can have the medical histories such as apoplexy, dizziness, wound.
3, neuropsychologic examination, cranium brain CT, MRI inspection etc. contributes to diagnosis.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, services once sooner or later, within 20th, is a course for the treatment of.
Four, efficacy assessment standard (according to the situation of change of the forward and backward clinical symptoms for the treatment of)
Effective: cardinal symptom disappears substantially, life can be taken care of oneself, and can carry out normal social activity.
Effective: symptom alleviates, life is taken care of oneself substantially, but bradykinesia, intelligence partial impairment.
Invalid: symptom is without changing or aggravation.
Five, therapeutic outcome statistics
Wherein: total effective rate=obvious effective rate+effective percentage
Model case and curative effect:
Case one, Wu, female, 69 years old age, senile dementia, always a period of time is felt the obvious variation of short term memory power, the first few minutes of going out just decide will with thing, exactly forgotten, after going out, come back again, have to turn back and take, repeatedly occur, and number of times increases gradually.Patient takes Chinese medicine of the present invention after the course for the treatment of, and symptom disappears substantially.
Case two, Ma, man, 70 years old age, senile dementia, suffer from hypertension throughout the year, never think that he is own ill or have a bad memory, being also unwilling, others says his state of an illness, almost can forget all things of just having done, but memory at a specified future date is but very clear, time and the time of forgetting and days.Patient takes Chinese medicine of the present invention after two courses for the treatment of, and symptom alleviates, and can carry out normal social activity, takes a turn for the better.
Case three, Chen, man, 58 years old age., there is the computing capability symptom that goes down for 2010 in senile dementia, forgetful, occurs the situation on Bu Ren road, symptom development half a year recently, than very fast, has not been familiar with the children of oneself, forgets name, is not familiar with the lover of oneself, can only be accompanied by household now, occur gatism, can not take care of oneself.Patient takes Chinese medicine of the present invention after two courses for the treatment of, and symptom alleviates, life partial self-help.
Claims (2)
1. a Chinese medicine composition for the treatment of senile dementia, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Corydalis 15-25 part, Radix Paeoniae Rubra 10-20 part, Fructus Atriplicis Sibiricae 15-25 part, Fructus Citri Sarcodactylis 10-20 part, Fructus Citri 10-20 part, Rhizoma Chuanxiong 7-17 part, Flos Carthami 5-15 part, Moschus 0.03-0.07 part, Spina Gleditsiae 20-28 part, Radix Angelicae Sinensis 13-23 part, Radix Astragali 25-35 part, Flos Albiziae 10-20 part, Radix Glycyrrhizae 3-9 part, Rhizoma Zingiberis Recens 6-12 part, Fructus Jujubae 3-7 part.
2. the Chinese medicine composition for the treatment of senile dementia according to claim 1, it is characterized in that, by the ingredients of following weight portion: 30 parts of Radix Salviae Miltiorrhizaes, 20 parts of Rhizoma Corydalis, 15 parts of Radix Paeoniae Rubra, 20 parts of Fructus Atriplicis Sibiricaees, 15 parts of Fructus Citri Sarcodactylis, 15 parts of Fructus Citris, 12 parts of Rhizoma Chuanxiongs, 10 parts, Flos Carthami, 0.05 part, Moschus, 24 parts of Spina Gleditsiaes, 18 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, 15 parts of Flos Albiziaes, 6 parts of Radix Glycyrrhizae, 9 parts, Rhizoma Zingiberis Recens, 5 parts, Fructus Jujubae.
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| CN104288646B (en) * | 2014-10-31 | 2017-12-26 | 张泽 | A kind of Chinese medicine preparation for improving memory |
| CN104548020B (en) * | 2014-12-31 | 2017-11-07 | 东莞市智健医疗科技有限公司 | A kind of purposes of pharmaceutical composition in treatment senile dementia is prepared |
| CN104547367A (en) * | 2014-12-31 | 2015-04-29 | 东莞市智健医疗科技有限公司 | Use of traditional Chinese medicine composition in preparation of medicine for treating Alzheimer's disease |
| CN105079629B (en) * | 2015-08-17 | 2018-08-17 | 齐齐哈尔医学院 | It is a kind of to be used to prevent Chinese medicine composition of Alzheimer disease and its preparation method and application |
| CN105582394A (en) * | 2016-03-22 | 2016-05-18 | 广州三得医疗科技有限公司 | Chinese herb preparation containing folium artemisiae argyi and treating senile dementia and preparation method thereof |
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