CN103127472B - Traditional Chinese medicine compound for refractory insomnia - Google Patents
Traditional Chinese medicine compound for refractory insomnia Download PDFInfo
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- CN103127472B CN103127472B CN201310094412.1A CN201310094412A CN103127472B CN 103127472 B CN103127472 B CN 103127472B CN 201310094412 A CN201310094412 A CN 201310094412A CN 103127472 B CN103127472 B CN 103127472B
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Abstract
The invention discloses a traditional Chinese medicine compound for refractory insomnia, which comprises the following components according to certain weight ratio: dried rehmannia root, radix asparagi, radix ophiopogonis, spina date seed, platycladi seed, radix scrophulariae, salvia miltiorrhiza, cortex moutan, gardenia, radix bupleuri, chinese angelica, white paeony root, poria, radix curcumae, caulis polygoni multiflori, mother of pearl and dens draconis. The traditional Chinese medicine compound has the effects of removing heat to cool blood, promoting the secretion of saliva or body fluid and tranquilizing mind by nourishing heat, thus being capable of treating refractory insomnia effectively.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for intractable insomnia.
Background technology
Insomnia is not enough with the length of one's sleep, Depth of sleep not and can not allaying tiredness, regain one's strength and the energy disease that is principal character.The course of disease above person half a year is intractable insomnia.Intractable insomnia is mainly that to falling asleep, when sleep quality, sleep, the irritated emotional response of the phenomenon such as sound interference, early awakening and excessive anxiety, intense strain cause before falling asleep due to insomniac.Intractable insomnia is referred to as " being insomnia ", " insomnia ", " must not crouch ", " unable to close the eyes " in traditional Chinese medical science ancient books, is common clinical, frequently-occurring disease.This course of disease is long, and normal touching difficulty heals, thereby causes spirit and sensual very big misery to patient.Along with the quickening of people's rhythm of life, this sick sickness rate is in rising trend, is having a strong impact on patient's work and quality of life.Western medicine adopts calmness, hypnosis and antianxiety drugs treatment more, and therapeutic effect is not good, and can not life-time service.Compare with Western medicine, Chinese medicine has stable curative effect to the treatment of intractable insomnia, the advantage that toxic and side effects is little.In the treatment of the intractable insomnia especially of having a sleepless night, Chinese medicine plays an important role.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has good effect for intractable insomnia, the feature having no side effect.
The present invention selects Radix Rehmanniae, Radix Asparagi, Radix Ophiopogonis, Semen Ziziphi Spinosae, Semen Platycladi, Radix Scrophulariae, Radix Salviae Miltiorrhizae, Cortex Moutan, Fructus Gardeniae, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Radix Curcumae, Caulis Polygoni Multiflori, Concha Margaritifera, Dens Draconis to combine, make each efficacy of drugs produce synergism these drug regimens, make it to there is clearing away heat and cooling blood, the YIN nourishing of promoting the production of body fluid, the effect of tranquilizing by nourishing the heart, thus intractable insomnia can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Rehmanniae: be the root of dicotyledon medicine scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae.Nature and flavor sweet, bitter, cold.Enter the heart, liver, kidney channel.Effect: heat clearing away is nourished blood, the YIN nourishing of promoting the production of body fluid.Radix Rehmanniae has obvious sedation, and its site of action is at cerebral cortex, and its aqueous extract can suppress autonomic activities, and can strengthen the syngignoscism of HD pentobarbital sodium and penthiobarbital, also can resist the excitation of caffeine and sodium benzoate simultaneously.
Radix Asparagi: be the tuber of liliaceous plant Radix Asparagi (Radix Asparagi).Nature and flavor are cold, sweet, micro-hardship.Return lung, kidney, stomach warp.Effect: nourshing Yin and drynsessmoistening prescription; Lung heat clearing is promoted the production of body fluid, and calms the nerves.< < Japan hanako materia medica > >: relieving palpitation, moistening five ZANG-organs, beneficial skin, improving healthy complexion, mends five kinds of strain and seven kinds of impairment, controls lung qi and coughs, expectorant, migratory arthralgia pyretic toxicity, urticaria, unhappy haematemesis.
Radix Ophiopogonis: be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Sweet, the micro-hardship of nature and flavor, is slightly cold.GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Radix Ophiopogonis, decoct had sedation to central nervous system, also can strengthen the sedation of chlorpromazine, strengthened the syngignoscism of pentobarbital sodium.
Semen Ziziphi Spinosae: be the seed of Rhamnaceae plant Ziziphi Spinosae.Nature and flavor are sweet, sour, flat.GUIXIN, spleen, liver, gallbladder meridian.Effect: nourishing the liver, mind calming, calms the nerves, arresting sweating.The calmness of Semen Ziziphi Spinosae water solubility extract, hypnosis, anticonvulsant action.
Semen Platycladi: be the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor are sweet, flat.GUIXIN, kidney, large intestine channel.Effect: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Semen Platycladi has calmness, syngignoscism.< < Sheng Nong's herbal classic > >: " cypress is real, and sweet in the mouth is flat, main palpitation with fear, and settling five organs, QI invigorating, except rheumatism numbness, clothes make us moist, beauty, normal hearing and eyesight for a long time.”
Radix Scrophulariae: be the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..Nature and flavor are sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.< < medicine origin > >: control that the regretful Nang of the heart is tired and insomnia is wild utterly confused, stasis dysuria.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor are bitter, are slightly cold.Enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are bitter, pungent, are slightly cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Paeonol can hypnotic and convulsion to central nervous system.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae ardenia jasminoides Ellis.Nature and flavor are bitter, cold; Nontoxic.GUIXIN, liver, lung, stomach, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.The composition such as Fructus Gardeniae and contained iridoid glycoside all has choleretic effect, and Fructus Gardeniae alcohol extract can reduce spontaneous activity, has sedation, and has synergism with ciclobarbital soluble, can extend the length of one's sleep, can resist the convulsions of pentetrazole.< < medicine class on the analogy of natural things > >: control vexed annoyance, tired insomnia, wild utterly confused, blood band, dysuria.
Radix Bupleuri: be dry root or the herb of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor are slightly cold, and hardship is pungent.Return liver, lung, spleen channel.Effect: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.< < medicineization justice > >: Radix Bupleuri, property is gently clear, and main liter is loose, and mildly bitter flavor is main soothing the liver.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia to central nervous system.
The Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor are bitter, sour, cool.Return liver, spleen channel.Effect: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Paeoniflorin has good spasmolysis and analgesic activity.< < medicine origin > >: " peace spleen channel, controls stomachache, receives gastric qi, antidiarrheal profit, and blood, fixing striae, eliminating pathogen in the liver, tonifying the spleen and stomach."
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Poria decoct has obvious sedation.< < modality > >: " cure mainly the Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side.”
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor are pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Caulis Polygoni Multiflori: be rattan or the leaf bine stem of dicotyledon medicine polygonum multiflorum thunb.Sweet, the micro-hardship of nature and flavor, flat.Enter the heart, spleen, kidney, Liver Channel.Effect: nourish heart, calm the nerves, dredging collateral, dispels the wind.Complex acid Semen Ziziphi Spinosae, grows the heart-yin, mind calming god; Join the Radix Rehmanniae, the nourishing YIN of nourishing blood; Join Radix Asparagi, Radix Ophiopogonis, clear asthenic fire, the moon nourishes heart.
The shell of Concha Margaritifera: Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea) or cristaria plicata Cristaria plicata (Leach).Nature and flavor are salty, cold.Return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, the improving eyesight of calming the nerves, calm the frightened.The maincenter of pentobarbital sodium is suppressed to have obvious synergism.
Dens Draconis: for ancient times mammal as if the fossil of the tooth of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor are puckery, sweet, cool.GUIXIN, Liver Channel.Function: tranquillizing the mind by relieving convulsion; Clearing heat and relieving fidgetness.< < property of medicine opinion > >: relieving palpitation, peace soul.
Medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope: Radix Rehmanniae 55-65 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 25-35 part, Semen Platycladi 7-17 part, Radix Scrophulariae 10-20 part, Radix Salviae Miltiorrhizae 20-28 part, Cortex Moutan 7-17 part, Fructus Gardeniae 5-15 part, Radix Bupleuri 4-14 part, Radix Angelicae Sinensis 7-17 part, Radix Paeoniae Alba 20-28 part, Poria 10-20 part, Radix Curcumae 5-15 part, Caulis Polygoni Multiflori 25-35 part, Concha Margaritifera 45-55 part, Dens Draconis 45-55 part.
Wherein be preferably: 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made to powder takes after mixing it with water; Can use decocting, obtain after filtration filtrate, add antiseptic to make oral liquid; Also can directly take decoction if desired.
Medicine of the present invention has clearing away heat and cooling blood, and the effects such as YIN nourishing, tranquilizing by nourishing the heart of promoting the production of body fluid, and good effect, have no side effect, and according to clinical 100 routine patients are observed to statistics, uses 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 95%.
The specific embodiment
Embodiment mono-, 55 parts of Radix Rehmanniae, 10 parts of Radix Asparagis, 10 parts of Radix Ophiopogonis, 25 parts of Semen Ziziphi Spinosaes, 7 parts of Semen Platycladi, 10 parts of Radix Scrophulariaes, 20 parts of Radix Salviae Miltiorrhizaes, 7 parts of Cortex Moutans, 5 parts of Fructus Gardeniaes, 4 parts of Radix Bupleuri, 7 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 10 parts, Poria, 5 parts of Radix Curcumaes, 25 parts of Caulis Polygoni Multiflori, 45 parts of Concha Margaritiferas, 45 parts of Dens Draconiss.
Embodiment bis-, 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
Embodiment tri-, 65 parts of Radix Rehmanniae, 20 parts of Radix Asparagis, 20 parts of Radix Ophiopogonis, 35 parts of Semen Ziziphi Spinosaes, 17 parts of Semen Platycladi, 20 parts of Radix Scrophulariaes, 28 parts of Radix Salviae Miltiorrhizaes, 17 parts of Cortex Moutans, 15 parts of Fructus Gardeniaes, 14 parts of Radix Bupleuri, 17 parts of Radix Angelicae Sinensis, 28 parts of the Radix Paeoniae Albas, 20 parts, Poria, 15 parts of Radix Curcumaes, 35 parts of Caulis Polygoni Multiflori, 55 parts of Concha Margaritiferas, 55 parts of Dens Draconiss.
The clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept patient's totally 100 examples for medical treatment, male's 32 examples wherein, women's 68 examples, M-F 0.5:1,43 years old mean age.
Two, tcm diagnosis standard:
1, the lighter's difficulty of falling asleep or sleep but easy to wake, be insomnia after waking up, and severe one is lain awake all night.
2, often with headache, giddy, cardiopalmus, forgetful, the diseases such as dreaminess.
3, no abnormal through each system and lab testing.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, services once sooner or later, within 20th, is a course for the treatment of.
Four, efficacy assessment standard
1, cure: easily fall asleep or sleep and recover normal, can sleep more than 7 hours every night, subjective symptoms disappears substantially;
2, effective: sleep obviously improves, and falls asleep easier, can sleep every night more than 5 hours, subjective symptoms SPR;
3, effective: after treatment, still can fall asleep, sleep extends 2-3 hour, and subjective symptoms before alleviates, or occasionally have slight recurrence;
4, invalid: after treatment, sleep state and subjective symptoms have no improvement.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+obvious effective rate+effective percentage
Model case and curative effect:
Case one, Zheng, female, 28 years old age, intractable insomnia 4 years, difficulty falling asleep, often lies on a bed and all can not fall asleep for three or four hours, even if fall asleep, also often has horrible nightmares, often early awakening, again cannot fall asleep after waking up, the second day panesthesia's fatigue and weak, vexed that gets up.Patient takes Chinese medicine of the present invention after the course for the treatment of, and sleep obviously improves, and falls asleep easier, can sleep about 7 hours every night, and subjective symptoms disappears substantially, cures.
Case two, Chen, female, 33 years old age, teacher.Over nearly 7 years, often insomnia, sometimes all through the night, is difficult to fall asleep, dizzy aggravation, and spiritlessness and weakness, hypomnesis, is often used tranquilizer hypnosis.Patient takes Chinese medicine of the present invention after two courses for the treatment of, and sleep obviously improves, and falls asleep easier, can sleep every night more than 5 hours, and subjective symptoms SPR, effective.
Case three, Wu, female, 54 years old age, be subject to have a sleepless night more than ten years after direct stimulation, long-term taking hypnosis Western medicine, and with dizziness, uncomfortable in chest, poor memory, extremity are tired, and the food of receiving is general, and light red tongue, yellow fur are slightly turbid, stringy and rolling pulse, every physico-chemical examination is without extremely.Patient takes Chinese medicine of the present invention after two courses for the treatment of, can fall asleep, and sleep extends about 5 hours, and subjective symptoms before alleviates, effectively.
Claims (2)
1. the Chinese medicine composition for intractable insomnia, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Rehmanniae 55-65 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 25-35 part, Semen Platycladi 7-17 part, Radix Scrophulariae 10-20 part, Radix Salviae Miltiorrhizae 20-28 part, Cortex Moutan 7-17 part, Fructus Gardeniae 5-15 part, Radix Bupleuri 4-14 part, Radix Angelicae Sinensis 7-17 part, Radix Paeoniae Alba 20-28 part, Poria 10-20 part, Radix Curcumae 5-15 part, Caulis Polygoni Multiflori 25-35 part, Concha Margaritifera 45-55 part, Dens Draconis 45-55 part.
2. the Chinese medicine composition for intractable insomnia according to claim 1, it is characterized in that, by the ingredients of following weight portion: 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
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| CN103877199A (en) * | 2013-12-10 | 2014-06-25 | 济南新起点医药科技有限公司 | Traditional Chinese medicine composition for treating insomnia caused by fire excess from yin deficiency |
| CN105878886A (en) * | 2014-12-17 | 2016-08-24 | 杨少梅 | Medicine for treating sleep disorder |
| CN105233207B (en) * | 2015-10-19 | 2020-10-13 | 南阳医学高等专科学校 | Traditional Chinese medicine composition for relieving pressure, soothing heart, strengthening brain and improving intelligence |
| CN106421310A (en) * | 2016-07-01 | 2017-02-22 | 覃益祥 | Brain-strengthening and eyesight-improving traditional Chinese medicine |
| CN105999113B (en) * | 2016-07-22 | 2019-10-29 | 刘德喜 | A kind of Chinese medicine composition and preparation method thereof for treating intractable aypnia |
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| CN101138615A (en) * | 2007-09-14 | 2008-03-12 | 尹克华 | Chinese medicine for treating intractable aypnia |
| CN101549054A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for safely and effectively treating insomnia and preparation method thereof |
| CN101549078A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for treating intractable insomnia and preparation method thereof |
| CN101985010A (en) * | 2010-07-02 | 2011-03-16 | 荣成市科学技术情报研究所 | Chinese medicinal composition for treating insomnia caused by depression |
| CN102698104A (en) * | 2012-06-06 | 2012-10-03 | 张俊波 | Medicine for treating climacteric syndrome and preparation method |
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