CN102973614B - 一种防治老年痴呆症的益生菌活性保健液及其制备方法 - Google Patents
一种防治老年痴呆症的益生菌活性保健液及其制备方法 Download PDFInfo
- Publication number
- CN102973614B CN102973614B CN201210580618.0A CN201210580618A CN102973614B CN 102973614 B CN102973614 B CN 102973614B CN 201210580618 A CN201210580618 A CN 201210580618A CN 102973614 B CN102973614 B CN 102973614B
- Authority
- CN
- China
- Prior art keywords
- senile dementia
- parts
- probiotics
- care fluid
- health promoting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 60
- 206010039966 Senile dementia Diseases 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000006041 probiotic Substances 0.000 title abstract description 29
- 235000018291 probiotics Nutrition 0.000 title abstract description 29
- 239000012530 fluid Substances 0.000 title abstract 6
- 241000894006 Bacteria Species 0.000 claims abstract description 53
- 244000235858 Acetobacter xylinum Species 0.000 claims abstract description 17
- 235000002837 Acetobacter xylinum Nutrition 0.000 claims abstract description 17
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 17
- 230000000243 photosynthetic effect Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 11
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 10
- 235000012907 honey Nutrition 0.000 claims abstract description 9
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 5
- 241000186660 Lactobacillus Species 0.000 claims abstract description 4
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 4
- 244000068988 Glycine max Species 0.000 claims abstract description 3
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 3
- 230000036541 health Effects 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 34
- 230000000529 probiotic effect Effects 0.000 claims description 32
- 230000001737 promoting effect Effects 0.000 claims description 24
- 230000001580 bacterial effect Effects 0.000 claims description 17
- 230000002265 prevention Effects 0.000 claims description 15
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 13
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 7
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 6
- 229920001202 Inulin Polymers 0.000 claims description 6
- 244000199885 Lactobacillus bulgaricus Species 0.000 claims description 6
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 6
- 238000000855 fermentation Methods 0.000 claims description 6
- 230000004151 fermentation Effects 0.000 claims description 6
- -1 fructose oligosaccharides Chemical class 0.000 claims description 6
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 6
- 229940029339 inulin Drugs 0.000 claims description 6
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 4
- 239000012809 cooling fluid Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 230000003068 static effect Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 2
- 244000182067 Fraxinus ornus Species 0.000 claims description 2
- 235000002917 Fraxinus ornus Nutrition 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 241001071795 Gentiana Species 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 abstract description 25
- 102000004190 Enzymes Human genes 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 14
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 13
- 229910001385 heavy metal Inorganic materials 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 8
- 230000000968 intestinal effect Effects 0.000 abstract description 7
- 206010027439 Metal poisoning Diseases 0.000 abstract description 5
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 208000011580 syndromic disease Diseases 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 4
- 208000010501 heavy metal poisoning Diseases 0.000 abstract description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 210000000601 blood cell Anatomy 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 230000008569 process Effects 0.000 description 16
- 239000002609 medium Substances 0.000 description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 13
- 239000011575 calcium Substances 0.000 description 13
- 229910052791 calcium Inorganic materials 0.000 description 13
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 12
- 238000011081 inoculation Methods 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 230000001954 sterilising effect Effects 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 230000003930 cognitive ability Effects 0.000 description 7
- 229920001817 Agar Polymers 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000001888 Peptone Substances 0.000 description 6
- 108010080698 Peptones Proteins 0.000 description 6
- 244000046052 Phaseolus vulgaris Species 0.000 description 6
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 6
- 239000008272 agar Substances 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 6
- 235000019341 magnesium sulphate Nutrition 0.000 description 6
- 235000019319 peptone Nutrition 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 5
- 239000004411 aluminium Substances 0.000 description 5
- 210000001772 blood platelet Anatomy 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 239000001632 sodium acetate Substances 0.000 description 5
- 229960004249 sodium acetate Drugs 0.000 description 5
- 235000017281 sodium acetate Nutrition 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 230000003412 degenerative effect Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 3
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 229940041514 candida albicans extract Drugs 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 244000005709 gut microbiome Species 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 238000011218 seed culture Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000012138 yeast extract Substances 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 206010010254 Concussion Diseases 0.000 description 2
- 206010057315 Daydreaming Diseases 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 241001609931 bacterium 20 Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 230000009514 concussion Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- YXVFQADLFFNVDS-UHFFFAOYSA-N diammonium citrate Chemical compound [NH4+].[NH4+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O YXVFQADLFFNVDS-UHFFFAOYSA-N 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004068 intracellular signaling Effects 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- GWHQHAUAXRMMOT-MERQFXBCSA-N 2,3-dihydroxybutanedioic acid;[3-[(1s)-1-(dimethylamino)ethyl]phenyl] n-ethyl-n-methylcarbamate Chemical compound OC(=O)C(O)C(O)C(O)=O.CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 GWHQHAUAXRMMOT-MERQFXBCSA-N 0.000 description 1
- 102000005606 Activins Human genes 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000033240 Progressive symmetric erythrokeratodermia Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 229940039856 aricept Drugs 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 206010009259 cleft lip Diseases 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940108366 exelon Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002454 frontal bone Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000004020 intracellular membrane Anatomy 0.000 description 1
- AXONCVPTTFHNOI-UHFFFAOYSA-N kairine Chemical compound C1=CC(O)=C2N(C)CCCC2=C1 AXONCVPTTFHNOI-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000003132 peptidolytic effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229950010673 rivastigmine hydrogen tartrate Drugs 0.000 description 1
- GWHQHAUAXRMMOT-MBANBULQSA-N rivastigmine tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 GWHQHAUAXRMMOT-MBANBULQSA-N 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 108010046845 tryptones Proteins 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210580618.0A CN102973614B (zh) | 2012-12-28 | 2012-12-28 | 一种防治老年痴呆症的益生菌活性保健液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210580618.0A CN102973614B (zh) | 2012-12-28 | 2012-12-28 | 一种防治老年痴呆症的益生菌活性保健液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102973614A CN102973614A (zh) | 2013-03-20 |
CN102973614B true CN102973614B (zh) | 2014-12-31 |
Family
ID=47848149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210580618.0A Active CN102973614B (zh) | 2012-12-28 | 2012-12-28 | 一种防治老年痴呆症的益生菌活性保健液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102973614B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103330256B (zh) * | 2013-06-03 | 2015-02-11 | 张志军 | 一种益生菌保健饮料及其制作方法 |
CN105670895B (zh) * | 2016-01-22 | 2018-12-25 | 华坪县星火农贸有限公司 | 一种芒果醋、芒果醋饮料及其制备方法 |
CN107232459B (zh) * | 2017-06-01 | 2020-12-29 | 沈阳师范大学 | 一种具有健脾养胃功能饮品的制备方法 |
KR102130485B1 (ko) * | 2017-10-13 | 2020-07-06 | 주식회사 엠디헬스케어 | 세균 메타게놈 분석을 통한 알츠하이머치매 진단방법 |
CN108094794B (zh) * | 2017-12-31 | 2021-01-05 | 佛山市艳晖生物科技有限公司 | 一种解酒护肝的复合微生物饮品及其制备方法 |
CN109172612B (zh) * | 2018-10-26 | 2022-03-15 | 北京科技大学 | 一种基于光合细菌的防治精神障碍的生物制剂及其应用 |
CN111202754A (zh) * | 2019-03-11 | 2020-05-29 | 江苏佰澳达生物科技有限公司 | 一种预防和改善老年痴呆症的益生菌组合物及其应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101933620A (zh) * | 2009-07-01 | 2011-01-05 | 何黎明 | 一种益生菌粉和制备方法 |
CN102475278A (zh) * | 2010-11-27 | 2012-05-30 | 叶奉奇 | 延命丸 |
CN102475276A (zh) * | 2010-11-27 | 2012-05-30 | 冯文光 | 益生菌胶囊 |
CN102783546A (zh) * | 2011-05-14 | 2012-11-21 | 冯帅 | 老年痴呆症防治麻酥糖 |
-
2012
- 2012-12-28 CN CN201210580618.0A patent/CN102973614B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101933620A (zh) * | 2009-07-01 | 2011-01-05 | 何黎明 | 一种益生菌粉和制备方法 |
CN102475278A (zh) * | 2010-11-27 | 2012-05-30 | 叶奉奇 | 延命丸 |
CN102475276A (zh) * | 2010-11-27 | 2012-05-30 | 冯文光 | 益生菌胶囊 |
CN102783546A (zh) * | 2011-05-14 | 2012-11-21 | 冯帅 | 老年痴呆症防治麻酥糖 |
Non-Patent Citations (1)
Title |
---|
具有抑制单胺氧化酶作用的益生菌筛选;王豪;《中国优秀硕士学位论文全文数据库》;20110414;全文 * |
Also Published As
Publication number | Publication date |
---|---|
CN102973614A (zh) | 2013-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102973614B (zh) | 一种防治老年痴呆症的益生菌活性保健液及其制备方法 | |
Oak et al. | The effects of probiotics in lactose intolerance: A systematic review | |
CN103275905B (zh) | 具有预防糖尿病作用的鼠李糖乳杆菌ccfm0528 | |
CN103013879B (zh) | 一株具有高产γ-氨基丁酸能力的菌株 | |
CN106176833A (zh) | 一种防治糖尿病并控制体重的复合益生菌液及其制备方法 | |
CN105167072A (zh) | 一种功能性枸杞酵素及其制品的生产方法 | |
CN104544086A (zh) | 一种可改善肠道菌群的保健食品及其制备方法 | |
CN104543679A (zh) | 一种含益生菌的保健食品及其制备方法 | |
CN103333847B (zh) | 具有辅助降血脂功能的发酵乳杆菌grx08及其应用 | |
US20040071680A1 (en) | Microorganisms which are taken effects in preventing and/or treating obesity or diabetes mellitus | |
JP2011193877A (ja) | 発酵及び培養方法、植物発酵エキス、植物発酵エキス末並びに該植物発酵エキス配合物 | |
CN111560331B (zh) | 一株副干酪乳杆菌及其应用 | |
CN105770066A (zh) | 一种益生菌发酵中药复合制剂及其制备方法和应用 | |
CN105039217A (zh) | 一种降血糖益生菌制剂及其制备方法 | |
CN108244432A (zh) | 一种发酵蛹虫草益生菌饮料及其制备方法 | |
CN110106122A (zh) | 一种能够改善睡眠的植物乳杆菌及其用途 | |
CN112056399A (zh) | 一种增强免疫力的益生菌组合物及其应用 | |
CN106138114A (zh) | 一种防治糖尿病并控制体重的复合益生菌制剂的制备方法 | |
CN106579387A (zh) | 一种***糖酵素组合物及制备方法 | |
CN104543680A (zh) | 一种抗疲劳、改善胃肠功能的保健食品及其制备方法 | |
CN111213885A (zh) | 一种具有调节血脂功效的益生菌组合物及其制备方法与应用 | |
WO2011063597A1 (zh) | 一种治疗糖尿病的复合微生物制剂及其制备方法和应用 | |
Li et al. | In-vitro digestion by simulated gastrointestinal juices of Lactobacillus rhamnosus cultured with mulberry oligosaccharides and subsequent fermentation with human fecal inocula | |
CN108283285A (zh) | 一种糖尿病的理疗保健食品 | |
CN110643524A (zh) | 一种具有胃肠道粘膜保护作用的复合益生菌制剂及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: ZHANG HUA Free format text: FORMER OWNER: JIANG CHANGDE Effective date: 20141222 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Hua Inventor after: Xue Mei Inventor after: Diao Yuchuo Inventor before: Jiang Changde Inventor before: Hu Yanhui Inventor before: Jiang Zhinuo |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 422213 SHAOYANG, HUNAN PROVINCE TO: 266000 QINGDAO, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: JIANG CHANGDE HU YANHUI JIANG ZHINUO TO: ZHANG HUA XUE MEI DIAO YUQUAN |
|
TR01 | Transfer of patent right |
Effective date of registration: 20141222 Address after: 266000 Chongqing Middle Road, Licang District, Shandong, China, No. 217, No. Patentee after: Zhang Hua Address before: 422213 Shaoyang City, Hunan province Longhui beachhead Zhenlong County Zhu Cun group Patentee before: Jiang Changde |
|
CI01 | Correction of invention patent gazette |
Correction item: Inventor Correct: Zhang Hua|Xue Mei|Diao Yuchuo False: Jiang Changde|Hu Yanhui|Jiang Zhinuo Number: 53 Volume: 30 |
|
CI03 | Correction of invention patent |
Correction item: Inventor Correct: Zhang Hua|Xue Mei|Diao Yuchuo False: Jiang Changde|Hu Yanhui|Jiang Zhinuo Number: 53 Page: The title page Volume: 30 |
|
ERR | Gazette correction |
Free format text: CORRECT: INVENTOR; FROM: JIANG CHANGDE; HU YANHUI; JIANG ZHINUO TO: ZHANG HUA; XUE MEI; DIAO YUQUAN |
|
RECT | Rectification | ||
TR01 | Transfer of patent right |
Effective date of registration: 20181108 Address after: 056800 office building No. 1, Jianye street, Weixian Economic Development Zone, Handan, Hebei, A Patentee after: Far state holding group pharmaceutical Limited by Share Ltd Address before: 266000 No. 217 Chongqing Middle Road, Licang District, Qingdao, Shandong. Patentee before: Zhang Hua |
|
TR01 | Transfer of patent right |